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Researchers in Worcester are taking a closer look at Alzheimer's disease by studying the bacteria in the gut."Our main theory on this is that your gut microbiome influences your systemic immune profile which then affects your brain immune profile," said Dr. John Haran, associate professor of emergency medicine and microbiology and physiological systems at UMass Medical School and clinical director of the UMass Center for Microbiome Research.His team was just awarded a $3.3 million grant from the National Institute on Aging to explore how the gut microbiome can affect cognitive functioning.Haran said the microbiome is a complex organ made up of billions of cells and 70% of the immune system lies there.Last year, his team reported people diagnosed with Alzheimer's dementia share certain gut microbiomes that fuel inflammation. Now, they will study know what else that could mean."If the inflammation is being driven from the microbiome, there's two things that could happen. One it could be preventative, to not have the inflammation happens in the first place. Second, if that inflammation is kind of cured or quieted down, the immune system would have time to then to recover back," Haran said.The center is actively recruiting seniors living in the Worcester area, both with an Alzheimer's diagnosis and those without. To inquire about participating in the study, you can call 508-925-0348 or email umass.emresearch@gmail.com .

Researchers in Worcester are taking a closer look at Alzheimer's disease by studying the bacteria in the gut.

"Our main theory on this is that your gut microbiome influences your systemic immune profile which then affects your brain immune profile," said Dr. John Haran, associate professor of emergency medicine and microbiology and physiological systems at UMass Medical School and clinical director of the UMass Center for Microbiome Research.

His team was just awarded a $3.3 million grant from the National Institute on Aging to explore how the gut microbiome can affect cognitive functioning.

Haran said the microbiome is a complex organ made up of billions of cells and 70% of the immune system lies there.

Last year, his team reported people diagnosed with Alzheimer's dementia share certain gut microbiomes that fuel inflammation. Now, they will study know what else that could mean.

"If the inflammation is being driven from the microbiome, there's two things that could happen. One it could be preventative, to not have the inflammation happens in the first place. Second, if that inflammation is kind of cured or quieted down, the immune system would have time to then to recover back," Haran said.

The center is actively recruiting seniors living in the Worcester area, both with an Alzheimer's diagnosis and those without.

To inquire about participating in the study, you can call 508-925-0348 or email umass.emresearch@gmail.com .

Continued here:
Worcester researchers study link between microbiome and Alzheimer's disease - WCVB Boston

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