StemCell Therapy

Individuals living with type 1 and type 2 diabetes (T1D and T2D, respectively) are at greater risk of bone fractures, according to a systematic review update published in Bone.

Diabetes is a major public health concern as 1.6 million deaths were directly caused by the disease in 2016. Fractures, meanwhile, also pose concern as up to 20% of patients die in the first year after a hip fracture and less than half regain their previous level of function. Individuals with diabetes also have a higher mortality after a hip fracture compared with people without diabetes, the authors wrote.

Diabetes can cause a number of well-known complications including kidney problems, loss of eyesight, problems with your feet and nerve damage, said Tatiane Vilaca, MD, an author of the study. However, until now many people with diabetes and their doctors are unaware that they are also at greater risk of bone fractures.

Researchers searched databases such as Medline, Embase, and Cochrane for observational studies with age and gender-adjusted risk of fractures in adults with diabetes compared with adults without diabetes, published through March 25, 2020.

A total of 48 studies met inclusion criteria and 2 separate meta-analyses were created: 1 for hip fractures (including 42 studies) and 1 for non-vertebral fractures (including 17 studies). Any studies that overlapped were included if they reported different aspects of the same population, so as to be included in subgroup analyses.

In total, the studies in the hip fracture analysis reported data from 17,571,738 participants with 319,652 fractures, while the studies in the non-vertebral fracture review reported data from 2,978,487 participants with 181,228 fracture.

The analyses revealed:

However, there is currently no specific treatment for bone fragility in diabetes, and the skeleton is not widely recognized as a site for diabetes complications, authors wrote.

We hope that by raising awareness about the greater risk people with diabetes face, bone density and bone strength will become something that doctors assess routinely in patients with the condition in the same way they do currently for other well-known complications, said Richard Eastell, MD, a co-author of the study.

Reference:

Vilaca T, Schini M, Harnan S, et al. The risk of hip and non-vertebral fractures in type 1 and type 2 diabetes: a systematic review and meta-analysis update. Bone. Published online May 29, 2020. doi:10.1016/j.bone.2020.115457

See the rest here:
What Is the Association Between Bone Fractures and Diabetes? - AJMC.com Managed Markets Network

This entry was posted on July 11, 2020 at 4:50 pm and is filed under Diabetes. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed. |