Want FREE access to this Audio Article?
Complete the form below to unlock access to this Audio Article: "What are Progenitor Cells? Exploring Neural, Myeloid and Hematopoietic Progenitor Cells"
Every cell in the human body, and that of other mammals, originates from stem cell precursors. Progenitor cells are descendants of stem cells that then further differentiate to create specialized cell types.There are many types of progenitor cells throughout the human body. Each progenitor cell is only capable of differentiating into cells that belong to the same tissue or organ. Some progenitor cells have one final target cell that they differentiate to, while others have the potential to terminate in more than one cell type.
Stem cells share two qualifying characteristics. Firstly, all stem cells have the potential to differentiate into multiple types of cells. Secondly, stem cells are capable of unlimited self-replication via asymmetric cell division, a process known as self-renewal.There are two broad categories of stem cells found in all mammals. The first are embryonic stem cells. These cells arise from the inner cell mass of the blastocyst in an early-stage embryo. Embryonic stem cells are the blueprint used to create every cell in the body. Because they can be used to create any type of cell, they are known as pluripotent.
The second type of stem cells found in mammals are adult stem cells (or somatic stem cells). Unlike pluripotent embryonic stem cells, adult stem cells are more limited in relation to the type of cells that they become. Unlike embryonic stem cells that could be used to create any cell, adult stem cells are limited to generating cell types within a specific lineage, such as blood cells or cells of the central nervous system. This level of differentiation potential is termed multipotent.
Stem cells create two types of progeny: more stem cells or progenitor cells. All progenitor cells are descendants of stem cells. When it comes to cell differentiation, they fall on the spectrum between stem cells and fully differentiated (mature) cells.
Whilst stem cells have indefinite replication (left) progenitor cells can at most differentiate into multiple types of specialized cell (right).
Function:
Cellular repair or maintenance
Cell Potency:
Multipotent, oligopotent, or unipotent
Self-renewal:
Limited
Origin:
Stem cells
Creates:
Further differentiated cells (either progenitor cells of mature/fully differentiated cells)
Progenitor cells are an intermediary step involved in the creation of mature cells in human tissues and organs, the blood, and the central nervous system.
The human central nervous system (CNS) contains three types of fully differentiated cells: neurons, astrocytes and oligodendrocytes. The latter two are collectively known as glial cells.Every neuron, oligodendrocyte and astrocyte in the CNS evolves from the differentiation of neural progenitor cells (NPCs). NPCs themselves are produced by multipotent neural stem cells (NSCs). Both NPCs and NSCs are termed neural precursor cells.Before the 1990s, it was believed that neurogenesis terminated early in life. More recent studies demonstrate that the brain contains stem cells that are capable of regenerating neurons and glial cells throughout the human lifecycle. These stem cells have only been found in certain brain regions, including the striatum and lateral ventricle.
Hematopoietic progenitor cells (HPCs) are an intermediate cell type in blood cell development. HPCs are immature cells that develop from hematopoietic stem cells, cells that can both self-renew and differentiate into hematopoietic progenitor cells. HPCs eventually differentiate into one of more than ten different types of mature blood cells.Hematopoietic progenitor cells are categorized based upon their cell potency, or their differentiation potential. As blood cells develop, their potency decreases.
First, hematopoietic stem cells differentiate into multipotent progenitor cells. Multipotent progenitor cells are those with the potential to differentiate into a subset of cell types. These cells then differentiate into either the common myeloid progenitor (CMP) or common lymphoid progenitor (CLP). Both CMPs and CLPs are types of oligopotent progenitor cells (progenitor cells that differentiate into only a few cell types).
CMPs and CLPs continue to differentiate along cell lines into lineage-restricted progenitor cells that become final, mature blood cells.Myeloid progenitor cells are precursors to the following types of blood cells:
Lymphoid progenitor cells (also known as lymphoblasts) are precursors to other mature blood cell types, including:
The primary role of progenitor cells is to replace dead or damaged cells. In this way, progenitor cells are necessary for repair after injury and as part of ongoing tissue maintenance. Progenitor cells also replenish blood cells and play a role in embryonic development.
Neural progenitor cells (NPCs) are being explored alongside neural stem cells for their potential to treat diseases of or injury to the central nervous system. A deeper understanding of how these cells function on a cellular and molecular basis is needed to progress from early experimental research to therapeutic use.NPCs are currently utilized in research conducted on CNS disorders, development, cell regeneration and degeneration, neuronal excitability, and therapy screening. When compared to induced pluripotent stem cells, which are cells reprogrammed into a pluripotent state, NPCs can cut down on time in some experiments.Hematopoietic progenitor cells and stem cells are being researched for their capacity to treat blood cell disorders. They are also currently used to help treat patients with a variety of malignant and non-malignant diseases via bone marrow transplants that deliver bone marrow and peripheral blood progenitor cells to patients. These procedures can assist patients in recovering from the damage caused by chemotherapy.Additionally, researchers are examining the potential of using progenitor cells to create a variety of tissues, such as blood vessels, heart valves, and electrically conductive tissue for the cardiovascular system.
Read this article:
What are Progenitor Cells? Exploring Neural ... - Technology Networks
- Inhibitor Therapeutics, Inc. Provides Update on its Clinical Development Plan - August 25th, 2024
- Firefly Neuroscience, an AI-Driven Brain Health Company, to Host Shareholder Update Call on September 4th - August 25th, 2024
- Tevogen Bio Secures $6 Million Series C Preferred Stock Investment - August 25th, 2024
- PharmAla Launches MDMA Clinical Trial Tool for Researchers - August 25th, 2024
- Pfizer and BioNTech Receive U.S. FDA Approval & Authorization for Omicron KP.2-adapted COVID-19 Vaccine - August 25th, 2024
- Adaptive Biotechnologies to Participate in the Morgan Stanley 22nd Annual Global Healthcare Conference - August 25th, 2024
- Seer to Participate in the Morgan Stanley 22nd Annual Global Healthcare Conference - August 25th, 2024
- Travere Therapeutics to Present Abstracts at the Society for the Study of Inborn Errors of Metabolism Annual Symposium 2024 - August 25th, 2024
- Eton Pharmaceuticals to Participate at the H.C. Wainwright 26th Annual Global Investment Conference - August 25th, 2024
- Kane Biotech to Release Second Quarter 2024 Financial Results on August 29, 2024 – Conference Call to Follow - August 25th, 2024
- Fact-Checking Panama stem cell institute: cost, safety, efficacy, docs - August 27th, 2022
- Fact-checking stem cell supplements in 2022 - The Niche - August 27th, 2022
- ultimak akv - autado.pl - August 27th, 2022
- New Stem Cell Mechanism Discovered in Intestinal Epithelium - August 27th, 2022
- Digging into extensive Joe Rogan stem cell clinic ... - January 1st, 2022
- Couple marry at Celtic Park after groom told he has only weeks to live - Glasgow Live - January 1st, 2022
- A cloudy day in paradise for pharma tax havens in Cayman Islands & Bermuda? Impact of OECD tax deal on pharma in Cayman Islands and Bermuda tax... - January 1st, 2022
- Dad with multiple sclerosis who fought for treatment in Panama during Covid restrictions finds first round is 'reaping rewards' - South West Londoner - August 30th, 2021
- Multiple sclerosis and the experimental treatment giving families hope - South West Londoner - August 30th, 2021
- Exosome therapeutic Market 2020 Global Industry Growth, Trends, COVID-19 Impact Analysis, Share, Size and 2027 Forecasts Report - Farming Sector - December 26th, 2020
- Exosome Therapeutic Market 2020-2026 Thriving Worldwide || Major Gaints Jazz Pharmaceuticals, Inc., Boehringer Ingelheim International GmbH, ReNeuron... - December 4th, 2020
- Neil Riordan, PA, PhD - Stem Cell Institute - December 3rd, 2020
- Nobel Prize history from the year you were born - Morganton News Herald - December 3rd, 2020
- Exosome Therapeutic Market is Booming With Healthy CAGR || Major Gaints Jazz Pharmaceuticals, Inc., Boehringer Ingelheim International GmbH, ReNeuron... - November 3rd, 2020
- Exosome Therapeutic Market 2020-2026 Executive Summary, Introduction, Sizing, Analysis and Forecast || Major Gaints Jazz Pharmaceuticals, Inc.,... - November 3rd, 2020
- Boy, 3, who 'died' for seven minutes in race against time to get lifesaving treatment - Mirror Online - October 29th, 2020
- Global Exosome Therapeutic Market Analysis 2020 With COVID 19 Impact Analysis| Leading Players, Business Prospects, In-depth Analysis Research Report... - October 29th, 2020
- Check out what's happening around town with this week's community calendar - The Delaware County Daily Times - October 29th, 2020
- Exosome Therapeutic Market 2020-2026 || Major Gaints Jazz Pharmaceuticals, Inc., Boehringer Ingelheim International GmbH, ReNeuron Group plc,... - October 20th, 2020
- Sunburn The morning read of what's hot in Florida politics 10.9.20 - Florida Politics - October 10th, 2020
- RHOC star Meghan Kings son Hart, 2, diagnosed with Cerebral Palsy but insists he will live a full, ind - The Sun - October 10th, 2020
- Exosome therapeutic Market Recent Trends and Developments, Challenges and Opportunities, key drivers and Restraints over the Forecast Period 2020-2026... - October 10th, 2020
- Exosome Therapeutic Market (COVID 19 Impact Analysis) Data Highlighting Major Vendors, Promising Regions, Anticipated Growth Forecast To 2027 - Galus... - September 3rd, 2020
- Exosome Therapeutic Market (COVID 19 Impact Analysis) Data Highlighting Major Vendors, Promising Regions, Anticipated Growth Forecast To 2027 -... - August 28th, 2020
- Exosome Therapeutic Market 2020-2026 with Covid-19 Impact Analysis || Major Gaints Jazz Pharmaceuticals, Inc., Boehringer Ingelheim International... - August 28th, 2020
- Investigations in the Time of Coronavirus: Conducting FCPA Investigations during the Pandemic - JD Supra - August 20th, 2020
- Exosome therapeutic Market Enhancement And Its growth prospects forecast 2020 to 2027 - Scientect - August 17th, 2020
- EXOSOME THERAPEUTIC MARKET (Covid 19 Update) In-Depth Research on Market Dynamics, Applications & Emerging Growth Factors - Scientect - August 17th, 2020
- COVID-19: Investigations in the Time of Coronavirus: Conducting FCPA Investigations during the Pandemic - Lexology - August 17th, 2020
- Exosome Therapeutic Market 2020-2026 Industry Report : Size, Growth, Trends, Share, Revenue || Major Gaints Jazz Pharmaceuticals, Inc., Boehringer... - August 17th, 2020
- R3 International Now Offering Stem Cell Therapy Program for Crohns Disease, IBD and Ulcerative Colitis - PR Web - July 10th, 2020
- Nearly 2 years removed from serious back injury, Melstone cowboy J.R. Vezain continuing to progress - 406mtsports.com - July 1st, 2020
- Panama Stem Cell Clinic Reviews - Regenexx - February 12th, 2020
- Health care professionals offer insight to stem cell injection claims - WOWT - February 12th, 2020
- U.S. stem cell clinic offering unapproved therapies brings direct-to-consumer marketing to Ottawa - Ottawa Citizen - November 21st, 2019
- Dr. Neil Riordan, Cell Therapy Expert - RMI Clinic | Stem ... - October 5th, 2019
- Mesenchymal stem cells, Umbilical Cord Tissue, Umbilical ... - October 4th, 2019
- STEM Summer Programs | TeenLife - October 4th, 2019
- Stem Cell Therapy Cost? - Regenexx - October 2nd, 2019
- Stem Cell Therapy for Autism at the Panama Stem Cell Institute - September 14th, 2019
- Cost of Stem Cell Transplant - Beike Biotechnology - September 14th, 2019
- What Stem Cell Clinics Do You Trust? | BioInformant - May 4th, 2019
- Human Umbilical Cord Stem Cells for ... - Medistem Panama - February 6th, 2019
- The Cost Of Stem Cell Therapy And Why It's So Expensive ... - February 4th, 2019
- Stem Cell Treatments and Therapies from Beike Biotechnology - February 4th, 2019
- Domestic policy of the George W. Bush administration ... - January 28th, 2019
- Neil Riordan PhD - Medistem Panama - January 13th, 2019
- Nobel Prize Doctor Yamanaka: Stem Cell Progress 'Just the ... - November 17th, 2018
- Crowdfunding to have an advanced Stem cell treatment in ... - October 18th, 2018
- Stem Cell Institute - Panama - Inspire - August 18th, 2018
- My experience with stem cells therapy in Panama - MSWorld - July 18th, 2018
- Journal of Stem Cell Research and Therapy - Open Access ... - July 15th, 2018
- Stem Cell Cancer Treatment in Panama City, Panama - July 13th, 2018
- Stem Cell Therapy for Autism in Panama - Medical Tourism - July 4th, 2018
- Stem Cell Therapy A Rising Tide Neil H. RIordan, PA ... - June 20th, 2018
- Stem Cell Cancer Treatment in Panama - health-tourism.com - September 20th, 2017
- On the trail of yellow fever - Science Magazine - August 17th, 2017
- New method to 3D print living tissues developed - Livemint - August 17th, 2017
- Stem Cell Therapy || Patient Treatment Disclaimer || Stem ... - August 5th, 2017
- Birdies for Landry fundraiser golf outing set - Sturgis Journal - August 5th, 2017
- Deadly school explosion - Castanet.net - August 5th, 2017
- Derma Divine Serum - Plant Stem Cell Skin Repair ... - July 12th, 2017
- Support Ella's Endeavor with Autism - Areawide News - July 5th, 2017
- Wheelchair-bound Langley man raising funds for stem cell therapy in Central America - Surrey Now-Leader - July 5th, 2017
- Stem Cell Treatment for Cerebral Palsy - November 24th, 2016
- Stem Cell Treatment in Panama - Two Men's Stories ... - August 4th, 2016
- Stem Cell Therapy For Autism In USA World Stem Cells - August 4th, 2016
- Stem Cell Supplement | Stem Cell Worx News - August 4th, 2016
- Stem Cell Therapy for Autism - Medical Information - Panama Ci - August 4th, 2016
- Stem Cell controversy in Panama - Panama Real Estate - August 4th, 2016