StemCell Therapy

With the coronavirus SARS-CoV-2 on everyones mind these days, scientists are working to understand its characteristics. Tung Phan from the University of Pittburgh, for example, found many mutations in the genome of the virus, underlining its genetic diversity and the rapid evolution this pathogen is capable of.

This begs bigger questions, thoughlike what makes viruses so adaptable, and are they really alive?

First, their total number is staggering. It is estimated that there are 10 viruses for every bacterium on Earth. Curtis Suttle from the University of British Columbia in Vancouver compared the number of viruses in the oceans alone to the number of stars in the Universe, which is estimated to be 1023. Viruses outnumber stars by a factor of 10 million. If you lined them all up, that line would be 10 million light years long! To put it on a more conceivable scale, its been estimated that each day, more than 700 million viruses, mainly of marine origin, are deposited from Earths atmosphere onto every square meter of our planets surface.

The diversity of viruses is just as impressive. Some use DNA to pass on genetic information, some use RNA, and some use both during their life cycle. The information carrier can be single-stranded, double-stranded, or double-stranded with some regions being single-stranded. Viruses are like a natural lab seemingly playing around with genetic permutations and combinations. While most viruses are so small that they can only be observed directly with an electron microscope, others, like the giant Mimiviruses, reach the size of bacteria. When I worked in my lab with viruses that kill bacteriacalled bacteriophageswe did not count the actual viruses, but the number of bacteria they killed.

Viruses also have benefits. Most of the genetic information on Earth probably resides within them, and viruses are important for transferring genes between different species, increasing genetic diversity and ultimately enhancing evolution and the adaptation of various organisms to new environmental challenges. When life was first arising on Earth, they may have been critical to the evolution of the first cells. I imagine some kind of early Darwinian pond in which viruses and the first cells swapped genes with each other, nearly unimpeded, to come up with critical new adaptations, enhancing the survival of both under challenging early-Earth conditions.

So, are viruses alive?

It depends where we draw the border between non-life and life, which is likely a continuum toward increasing complexity. Does life require cells? Personally, I think thats a bithow should I say it?cell-centric rather than Earth-centric. In my view, viruses have to be counted as alive. We should recognize them as a fourth domain of life and not dismiss them, if only because they do in fact reproduce outside their own bodies. The parasitic bacteria that cause chlamydia are considered to be living. One hypothesis for the origin of viruses says that they, or at least some of them, could have evolved from bacteria that lost any genes not needed for parasitism. If so, could we say they evolved from living back to non-living?

Another thing I find intriguing: The more common RNA viruseslike the coronavirus behind the current pandemichave typically smaller genome sizes than DNA viruses, apparently because of a higher error-rate when replicating. Too many errors have the effect that natural selection disfavors them. It also limits the maximum size of these viruses.

This seems to support the hypothesis that life originated with an RNA world, and that for very primitive life RNA worked perfectly fine to pass on genetic information. As organisms grew in size, they required larger genomes and needed to transfer more information. At that point DNA outcompeted RNA as a type of informational code. But RNA survives as an essential part of terrestrial biology, as were seeing with the coronavirus SARS-CoV-2.

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Original post:
There Are More Viruses on Earth Than There Are Stars in the Universe - Air & Space Magazine

This entry was posted on March 18, 2020 at 1:47 am and is filed under Genetics. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed. |