It's a pursuit that seems more like the plot of a science fiction movie than an actual goal of serious researchers around the world. But a number of scientists are fiercely working toward what was once only attainable in fables and fairy tales: they want to end aging.
The quest has even inspired a competition with a monetary prize from that hub of innovation, Silicon Valley. The Palo Alto Longevity Prize, founded by Dr. Joon Yun, a radiologist who heads Palo Alto Investors, is offering $1 million in prize money as a way to urge researchers figure out how to "hack the code" of aging.
While those in the growing field of longevity research admit the task at hand is expansive and complex, they say big advancements have already been made and expect to see more in the near future.
"The goal is similar to all medical research which is to make people healthier and keep people alive longer so we can have more productive lives and not be such a burden to society," David Sinclair, Ph.D., a professor of genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at the Harvard Medical School, told CBS News.
The Australian-born biologist, who sits on the board of the Palo Alto Longevity Prize, discovered in 2013 that Nicotinamide adenine dinucleotide (NAD), a chemical found in every living organism, can turn on defenses against aging, though its levels decrease the older we grow.
Play Video
Atlantic Magazine contributing editor Gregg Easterbrook joins "CBS This Morning: Saturday" to discuss the consequences of rising longevity as ave...
Sinclair envisions a time -- maybe not too far away -- when doctors will prescribe medicine utilizing these findings to curb aging.
"We are finding genes and molecules that we can take as a pill that would slow down every disease from Alzheimer's to diabetes to cancer plus give us more energy during our whole lives," he said. "Side effects would be living longer, but the ultimate goal is there will be a future -- maybe it's only a decade or two away -- where people won't have to worry about getting these diseases in their 60s or 70s but can put that off to 100 or 110."
The Palo Alto Prize is meant to inspire and reward such innovations. The competition was announced in 2014 and final registration closed this past December. Winning research teams in two different categories -- who will be awarded $500,000 each -- are expected to be announced by the end of 2019.
The roughly 30 teams that are participating in the competition are taking a broad range of approaches, from stem cell therapies to gene modification to hormonal treatments to behavioral and nutritional interventions. Because of the nature of the competition, specifics about each project have not been disclosed to the public, but videos are available on the contest's website with teams introducing their research.
Quality versus quantity
Yun is quick to point out that the aim of most of longevity research -- and the ultimate goal of the Palo Alto competition -- is not simply to extend life in terms of sheer number of years lived, but to enhance quality of life, as well. He explains this in terms of homeostatic capacity, which refers to the body's natural ability to fight off stressors in order to remain healthy.
"Homeostatic capacity is probably nature's greatest gift. It's our ability to self-tune in response to stressors," he told CBS News. "It is so pervasively effective that we don't even realize we have it until we start losing it."
Yun went on to explain that when we're young and healthy, we don't even notice it. "That is the true definition of health," he said. "When you're feeling healthy, you're feeling nothing because you're in homeostasis. That's very different from what marketers try to say, that healthy means vitality and energy."
Then, after about the age of 40, our homeostatic capacity starts to decline. "We're more vulnerable to the forces of aging. All of a sudden you're finding that your body can't get back to homeostasis on its own," Yun said. "It's hard to ride roller coasters. It's hard to recover from injuries, from a late night, from jet lag. Foods we may have once loved, we are no longer able to tolerate. All of this happens at once, and these are all things everyone can feel. But think of all the things you can't feel."
He gave the example that when people are young and healthy and their blood pressure or sugar level is high, the body brings itself back to homeostasis on its own. But as we age, the body loses this ability.
"We give these things names like diabetes and hypertension," he said. "But maybe it's all really the same process that is the decline of homeostatic capacity."
When asked why he set up the competition to find ways to solve these problems of aging, rather than invest the money directly into research, Yun said he thinks the nature of a contest yields the best results.
"What's wonderful about prizes is that you set a goal and you're essentially inviting a diversity of options to compete and see which one wins," he said. "It's very much like how nature and evolution work."
"What is it that you're living for?"
But not everyone thinks the quest to cure aging is well-founded or wise. Several prominent bioethicists have spoken out against such efforts to extend longevity.
Dr. Ezekiel Emanuel, an oncologist and Chair of the Department of Medical Ethics and Health Policy at the University of Pennsylvania, is among them. In 2014, Emanuel penned a controversial article for the Atlantic titled "Why I Hope to Die at 75."
"I think it's fascinating that so many people are obsessed with living long," he told CBS News. "If you ask most people about quality versus quantity of life, they will say in a second that quality is what's really important. And then you probe and you find that people are so psychologically scared of dying and not having lived out a meaningful life. But when you talk to older people, many of them are sort of tired of life. They've lost friends and loved ones or activities are restricted and maybe it's not so great after all."
For Emanuel, such frank discussions with older adults and time spent in self-reflection led him to the decision that he does not aspire to an exceptionally long life and would not take steps to extend it.
In the Atlantic article, Emanuel, who is in good health in his late 50s, made clear that he is not looking to end his life through suicide or euthanasia. Rather, at 75, he believes he will be content enough with his life to not actively try to prolong it. "I think this manic desperation to endlessly extend life is misguided and potentially destructive," he wrote.
"The real issue is what makes a meaningful life," he told CBS News. "Is it living as long as you can or is there something else going on? If you ask me, it's the something else we really ought to care about. What is it that you're living for?"
When asked about the views expressed by longevity researchers that their work focuses not just on extending years lived, but on increasing quality of life, Emanuel answered with plenty of skepticism.
"How are you going to cure all of the causes of death?" he asked. "That's kind of a way for scientists to rationalize what they're doing. I can understand that it's an interesting puzzle to solve and many people are passionate about it, but I don't think it's something we ought to be doing."
Of course, longevity researchers vehemently disagree and say such objections are misguided.
"What we're talking about is being able to prevent and treat the major diseases of society," Sinclair said. "Cancer at one point in human history was totally natural. Heart disease was unavoidable. Nobody now would say, 'Oh, cancer is natural and we shouldn't work on it.' We use our technology to lead better lives and make the world a better place and improve the human condition and that's what we're aiming to do here."
2016 CBS Interactive Inc. All Rights Reserved.
See the rest here:
The scientific quest to cure aging - CBS News
- I feel more alive than ever at 47 here's my 4-step routine - hellomagazine.com - April 14th, 2025
- Longevity Fitness: How to slow down aging and strategies to stay fit after middle age - Times of India - April 14th, 2025
- Living Longer and Better: The Rise of Longevity Clinics. But When Will They Be Accessible to Everyone? - Men's Health - April 14th, 2025
- Recent work suggests a connection between verbal factors and a longer lifespan. - Psychology Today - April 14th, 2025
- Aging In Place: Longevity In A Time Of Stress - CapeNews.net - April 14th, 2025
- Florida Wins National Title, a 101-Year-Olds Longevity Tips: What to Know TODAY - TODAY.com - April 14th, 2025
- Retirement could be bad for your health, says wellness expert: 'Powered by purpose' - Fox News - April 14th, 2025
- 101-Year-Old Nutrition Professor Shares 7 Tips For A Long Life - TODAY.com - April 14th, 2025
- Longevity and precision medicine driving the agenda at Abu Dhabi Global Health Week - PR Newswire - April 14th, 2025
- Sadhguru's 13 tips on right food habits that promote health and longevity - Times of India - April 14th, 2025
- Aging, regeneration and whole-body rejuvenation in long-lived planarians - Nature - April 14th, 2025
- Longevity expert says world's oldest people in Blue Zones 'never' drink this - Surrey Live - April 14th, 2025
- Technologies developed to clean up orbit and enhance satellite longevity - Space Daily - April 14th, 2025
- Longevity in theatre requires talent and skill and lucky timing - The Stage - April 14th, 2025
- FIBO 2025 opens with new longevity and wellness hall and conference - spaopportunities.com - April 14th, 2025
- What the Tech: Increasing your iPhone's longevity - KTBS - April 14th, 2025
- P90X trainer Tony Horton is in the best shape of his life at 66. Here are his top longevity tips. - Business Insider - April 14th, 2025
- This daily supplement can work wonders for longevity: Here's how to take it - Times of India - April 14th, 2025
- Is this longevity diet a magic pill for chronic diseases? Why Lancets planetary health diet can work for you - The Indian Express - April 14th, 2025
- Im a doctor why the French diet beats the Mediterranean diet for obesity, longevity and colon cancer - New York Post - April 14th, 2025
- So "Longevity Tea" Is A Thing & It's Easier To Make Than You'd Expect - MindBodyGreen - April 5th, 2025
- Longevity & Hospitality Summit: Transforming the future of hospitality - spaopportunities.com - April 5th, 2025
- Department of Health Abu Dhabi hosts inaugural Healthy Longevity Innovation Forum - MSN - April 5th, 2025
- Fat's surprising role in aging and longevity - WFTV - April 5th, 2025
- The creator of Kind Bars is now investing in longevity. Here's what his firm is betting on. - Business Insider - April 5th, 2025
- Try these moves tied to longevity and independence later in life - MSN - April 5th, 2025
- Longevity Beauty Brand Oneskin Launches Hair - The Business of Fashion - April 5th, 2025
- The science of brain longevity: The Magtein success story - NutraIngredients.com - April 5th, 2025
- Public invited to attend free conference on longevity: Focus Forward Long Live West Virginia - WV News - April 5th, 2025
- Dr Greger Reveals The 10 Blue Zones Food Guidelines To Lengthen Your Life - Plant Based News - April 5th, 2025
- NAD Supplements Promise to Improve Energy, Metabolism, and Longevity. Heres How Experts Recommend You Use Them - GQ - April 5th, 2025
- Longevity and Hyaluronic Acid, discover the novelties of LipoTrue at booth 1A80 - Cosmetics Business - April 5th, 2025
- The Longevity Superfood That Could Extend Your Life - Plant Based News - April 5th, 2025
- Nutritionist-approved 5 fruits that improve longevity and heart health - Times of India - April 5th, 2025
- Exclusive | 100-year-old NYC cabaret singer shares her secret to longevity: Everything about her is an inspiration - New York Post - April 5th, 2025
- The No. 1 Tip You Need To Live To 100, From A Longevity Expert - MindBodyGreen - April 5th, 2025
- I asked scientists about the best exercise for longevity - and they all said the same 3 workouts - Woman & Home - April 5th, 2025
- Longevity Is A Rich Man's Game. But What Does It Cost The Rest Of Us? - HuffPost UK - April 5th, 2025
- 'Fasting and the Longevity Revolution' Trailer Has Edward Norton Narrating Nutrition Doc - MovieWeb - April 5th, 2025
- The convergence of health, wealth and longevity Services - Deloitte - April 5th, 2025
- Longevity researcher shares secrets of the worlds blue zones - Fox News - March 19th, 2025
- Kyrgyzstan on the Threshold of an Aging Population: Government Develops Active Longevity Program - Times of Central Asia - March 19th, 2025
- Longevity dividend - Association of Health Care Journalists - March 19th, 2025
- Longevity: The cosmetics industry must rethink its approach to ageing - Premium beauty - March 19th, 2025
- Implantable biosensors get major longevity boost with coating technology that inhibits biofouling - Phys.org - March 19th, 2025
- Longevity vs. Metabolism: How Birds Cheat the Aging Process - SciTechDaily - March 19th, 2025
- Bon appetit, Cristiano Ronaldo! 'Unusual' dish behind 40-year-old's remarkable longevity - and where it can be bought - revealed - Goal.com - March 19th, 2025
- Secrets of the Greenland Sharks Longevity Revealed in New Study - The Brighter Side of News - March 19th, 2025
- Anthony Michael Hall Says Longevity Was Always His Goal As The Breakfast Club And Weird Science Turn 40 - Decider - March 19th, 2025
- LB Elandon Roberts' words on NFL longevity will have Raiders fans very excited to have him - Raiders Wire - March 19th, 2025
- Studies Undoubtedly Show This Vitamin Is Linked To LongevityHere's Why - mindbodygreen - March 19th, 2025
- 'Helps slow down ageing': Nutritionist names longevity foods that improve 'heart health and brain function' - GB News - March 19th, 2025
- Men With High-Quality Sperm May Have a Longer Life Expectancy - Everyday Health - March 19th, 2025
- Dr. Vonda Wright Shares the Longevity Habits Youre Not Thinking About (and That You Can Start Doing Today) - Maria Shriver's Sunday Paper - March 19th, 2025
- 99-Year-Old Dick Van Dyke Eats This Surprising Food Combo Every Day - Taste of Home - March 19th, 2025
- Climbing This Many Stairs A Week May Lead To A Longer Life - HuffPost UK - March 19th, 2025
- How to live longer: Supercentenarian who lived to 117 ate her go-to snack 3 times a day - GB News - March 19th, 2025
- Saudi Arabia Expands Regulatory Role To Shape The Future Of Health And Longevity - Citeline News & Insights - March 19th, 2025
- Crypto fans are obsessed with longevity and biohacking: Heres why - Cointelegraph - March 19th, 2025
- Unlocking the power of sleep: Longevity expert Dr Elie Abirached tells us how - Gulf Business - March 19th, 2025
- MST3K: Jonah Ray on Longevity, Evolution from Netflix to the Gizmoplex - Bleeding Cool News - November 27th, 2024
- Why Personal Health and Wellness Are Key to Business Longevity - Entrepreneur - November 27th, 2024
- How to live longer: 'I'm a doctor - adding two foods to your diet is the key to longevity' - GB News - November 27th, 2024
- The Best Talks of GSA 2024 - Lifespan.io News - November 27th, 2024
- Maren Tschinkel Shares Her 11 Healthy and Happy Habits - Bustle - November 27th, 2024
- Do blue zones, supposed havens of longevity, rest on shaky science? - Science - November 27th, 2024
- 2025 Longevity and Harmony coins recognize symbolism of birds - Coin World - November 27th, 2024
- The Hormonal Blueprint For Longevity And The Science Of Youthfulness - Forbes - November 27th, 2024
- How Has Life Expectancy Changed Throughout History? - Verywell Health - November 27th, 2024
- The key to a long life is avoiding the 'poisonous 5 P's,' says one of the world's top anti-aging experts - Fortune - November 27th, 2024
- Study unveils genetic secrets to longevity in Indian population - The Times of India - November 27th, 2024
- The Long Run: Behind The Song That Predicted Eagles Longevity - Dig! - November 27th, 2024
- Daily Walks Could Add More Than 10 Years to Your Life, New Study Says - Real Simple - November 27th, 2024
- The 5 best supplements for healthy aging, according to a longevity expert - Yahoo Finance - November 27th, 2024
- Longevity Burn-In Test: Updates And Results From 100 TVs - RTINGS.com - November 27th, 2024
- A 90-year-old comedian still does gigs and plays golf. She shared her secrets for staying fit and funny. - Business Insider - November 27th, 2024
- Longevity and Anti-senescence Therapy Global Market is set to reach $36.11 billion by 2028 at a CAGR of 6.4% - EIN News - November 27th, 2024
- Steinberg Hopes that the Runners Club Can Put Chatham on Course to 'Blue Zone' Longevity Status as Part of Mayor's Wellness - TAPinto.net - November 27th, 2024
- Why Brits are keen to go on wellness getaways for longevity in 2025 - Yahoo Lifestyle UK - November 27th, 2024
- 3 ancient foods are the staple of this blue zones longevity diet - Fortune - November 3rd, 2024