StemCell Therapy

Janelle Overhouse and her dog Rory, a patient at Texas A&Ms Veterinary Medical Teaching Hospital.

Michael Kellett/Texas A&M College of Veterinary Medicine & Biomedical Sciences

Doctors at the Texas A&M University College of Veterinary Medicine & Biomedical Sciences (CVMBS) Veterinary Medical Teaching Hospital (VMTH) were recently confronted with a big problem how to save a dog from a first-of-its-kind critical illness.

First, the six-year-old boxer named Rory was infected by a rare form of Salmonella that has never before been seen in a dog. And second, her Salmonella infection was the first to be found in a dogs brain.

Rorys story begins long before her infection. She first became a patient when she was diagnosed with a common, but serious, form of meningitis when she was a year old.

During her first visit to the VMTH in 2015, Rory was diagnosed with Steroid Responsive Meningitis-Arteritis (SRMA), an immune-mediated inflammatory disease common in boxers that can cause neck pain and fever.

Id never even heard of SRMA and didnt know anything about it, said Rorys owner Janelle Overhouse. Once I learned more, I found that it was something that could be chronic. That was really scary, because she was in a tremendous amount of pain.

Luckily, Rorys form of SRMA could be treated with a few months of immunosuppressive steroids that, when finished, allow the dog to return to a completely normal life. While SRMA tends to repeatedly flare up over the years, it can usually be treated the same way with minimal complications.

For some patients, however, the immunosuppressed state during treatment can cause its own problems, such as when dealing with infections that could normally be fought off by a healthy immune system. This was the case when it came to Rorys unique infection.

In late 2019, Rory was undergoing the final months of treatment for her first SRMA relapse when she began to show unusual symptoms.

Rory came back to the VMTH because she had some issues that didnt really fit SRMA, said Dr. Melissa Andruzzi, the veterinary chief resident at the hospital.

She had seizures and her behavior was very different. Shes normally a really happy-go-lucky kind of dog who loves everyone and wants to lick everyone, but now she was afraid of people and a little bit aggressive toward people she didnt know. It was just very different for her.

Working with veterinary neurologist Dr. Beth Boudreau, a CVMBS assistant professor, Andruzzi scheduled an MRI for Rory and noticed that her brain looked abnormal in some places, another issue not connected to SRMA. She then extracted a sample of spinal fluid and sent it to CVMBS associate professor Dr. Sara Lawhon and graduate assistant Mary Krath at the VMTHs Clinical Microbiology Lab, who found the presence of the Salmonella called enterica subspecies houtenae.

The infection was likely a bacteremia, meaning it had spread in her blood and had access to her whole body, she said. The reason her central nervous system was particularly affected is because its natural barrier (the blood brain barrier) was already compromised from her SRMA, allowing easy access for the Salmonella.

Despite the novel aspects of Rorys case, she was treated much like any other patient with a serious infection with several months of antibiotics. Rorys SRMA was fully cleared by the time she began her Salmonella treatments, allowing her to stop taking the immunosuppressant steroids and fight the infection with her full immune system.

Once Rory was back on the road to full health, only one question remained: How did she become the first dog to contract that form of Salmonella?

After talking to Overhouse, Andruzzi came to the conclusion that wild geckos in her backyard might have been the source of the infection.

This form of Salmonella is most commonly identified in reptiles and amphibians, and more than 90% of reptiles are asymptomatic carriers. They contaminate whatever environment theyre in, Andruzzi said. Rory very commonly interacted with these little geckos outside and in the garage. So while we dont know for sure, we think it probably came from that.

Even after Rory went home healthy and happy, the work was not done for Andruzzi and her coworkers.

After we had treated her so successfully, we thought it was very important to write her case up so that if anyone else saw this type of Salmonella in a dog, or any other Salmonella in a dogs brain or spinal cord, they at least would have Rorys case to read about and see how we treated her, Andruzzi said. We needed to contribute this knowledge so that other veterinarians can treat other pets just as well.

But for Overhouse, the joy from finally seeing her dog healthy outshines all other positive aspects of Rorys case.

Rorys doing really well now. You wouldnt know anything happened to her, Overhouse said. Her veterinary team was great; they seemed to really listen and they were all very caring. I feel like they really had her best interests at heart and I appreciated that very much.

Ive not had many other kinds of dogs besides boxers, so I know theyre very people oriented. Rory follows me everywhere I go, she said. She is definitely connected to me and I to her. Im always looking out for her.

Read the rest here:
Texas A&M Veterinarians Presented With First-Of-Its Kind Case - Texas A&M University Today

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