Stem cell therapy shows promise in repairing brain damage even hours after stroke occurs
Durham, NC Stroke is a major health concern and is a leading cause of death in the United States, according to the Center for Disease Control. Despite significant research efforts, developing treatments that ensure complete recovery for stroke patients poses an extreme challenge, especially when more than a few hours have passed between onset of the stroke and administration of treatment.
However, a new study released today in STEM CELLS Translational Medicine indicates that endothelial precursor cells, which are found in the bone marrow, umbilical cord blood, and as very rare cells in peripheral blood, could make a significant difference for these patients recovery even in the later stages of stroke. In animal studies, the treatment minimized the initial brain injury and helped repair the stroke damage.
Previous studies indicated that stem/progenitor cells derived from human umbilical cord blood (hUCB) improved functional recovery in stroke models, noted Branislava Janic, Ph.D., a member of Henry Ford Health Systems Cellular and Molecular Imaging Laboratory in Detroit and lead author of the study. We wanted to examine the effect of hUCB-derived AC133+ endothelial progenitor cells (EPCs) on stroke development and resolution in rats.
Dr. Janic and his team injected rats that had suffered strokes with the stem cells. When they later examined the animals using MRI, they found that the transplanted cells had selectively migrated to the injured area and that the stem cells stopped the tissue damage from spreading, instigated regeneration, and also affected the time course for stroke resolution. A significant decrease in lesion size also was observed, at a dose of 10 million cells, as early as seven days after the strokes onset.
This led us to conclude that cord blood-derived EPCs can significantly contribute to developing more effective treatments that allow broader time period for intervention, minimize the initial brain injury and help repair the damage in later post-stroke phases, Dr. Janic said.
The early signs of stroke are often unrecognized, and many patients cannot take advantage of clot-busting treatments within the required few hours after stroke onset, said Anthony Atala, M.D., editor of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine. In this animal study, a combination of stem cells shows promise for healing stroke damage when administered 24 hours after the stroke.
###
The full article, Intravenous administration of human umbilical cord blood derived AC133+ endothelial progenitor cells in rat stroke model reduces infarct volume magnetic resonance imaging (MRI) and histological findings, can be accessed at http://www.stemcellstm.com.
About STEM CELLS Translational Medicine: STEM CELLS TRANSLATIONAL MEDICINE (SCTM), published by AlphaMed Press, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices.
Read more:
Stem cell therapy shows promise in repairing brain damage
- My Life After MS: Ep 2 part 1-How I Got Pregant - Video - April 19th, 2015
- Telehealth Stem Cell Clinic Now Offering Wound Healing Guarantee - April 13th, 2015
- NYC Health & Longevity Center Now Offering Stem Cell Therapy to Avoid Joint Replacement - April 13th, 2015
- Stem Cell Therapy For Pain - Columbia Pain Management, Hood River OR - Video - April 12th, 2015
- U.S. Stem Cell Clinic: Patient Based Webinar - Video - April 12th, 2015
- Stem Cell Therapy for Pain - Now Available at Columbia Pain Management - Video - April 11th, 2015
- U.S. Stem Cell Clinic: Stem Cell Banking - Video - April 11th, 2015
- U.S. Stem Cell Clinic: What is Stem Cell Therapy? - Video - April 11th, 2015
- U.S. Stem Cell Clinic: How is Stem Cell Therapy Performed? - Video - April 11th, 2015
- Back Pain Stem Cell Therapy Doctors Tampa - Video - April 9th, 2015
- Regeneus hits key stem cell manufacturing milestone - April 9th, 2015
- Dr. Raj at Beverly Hills Orthopedic Institute Now Offering Stem Cell Therapy to Heal Chronic Tendonitis - April 7th, 2015
- Is a loophole in stem cell law helping new therapy to thrive, or allowing dubious science? - April 5th, 2015
- Can PRP and Stem Cell Therapy Help You? | Orlando Orthopaedic Center - Video - April 3rd, 2015
- Orthopedic Stem Cell Therapy for Arthritic Joint Pain - Video - April 3rd, 2015
- Induced Pluripotent Stem Cell (iPSC) Industry Complete Report 2015 - 2016 - April 3rd, 2015
- New study: Stem cell field is infected with hype - March 31st, 2015
- Arizona Pain Stem Cell Institute Now Offering Stem Cell Therapy to Help Patients Avoid Hip and Knee Replacement - March 30th, 2015
- Center of Regenerative Orthopedics in South Florida Now Offering Stem Cell Therapy to Help Avoid Hip and Knee ... - March 30th, 2015
- Ask Dr. Lemper | Stem Cell Therapy Treatments - Video - March 29th, 2015
- On stem cell therapy, benefits - March 26th, 2015
- Stem cell therapy could reverse Type 2 diabetes, UBC study finds - March 24th, 2015
- Nevada Pain Now Offering Stem Cell Therapy to Help Patients Delay or Avoid Joint Replacement - March 23rd, 2015
- Stem Cell Injection Treatment Stem Cell Therapy - Video - March 21st, 2015
- Stem cell therapy and me1 - Video - March 21st, 2015
- stem cell therapy di indonesia Jakarta tangerang serpong bsd bintaro - Video - March 21st, 2015
- Knee arthritis 3 years after stem cell therapy by Harry Adelson, N.D. - Video - March 21st, 2015
- Amniotic Stem Cell Therapy Discussed by R3 (844) GET-STEM - Video - March 19th, 2015
- Stem cell therapy may help treat type 2 diabetes - March 19th, 2015
- CAR T-Cell Therapy - Nebraska Medicine - Video - March 18th, 2015
- Stem Cell Therapy Now Being Offered for NonHealing Wounds at Telehealth's Three Regenerative Medicine Clinics - March 18th, 2015
- Beware stem cell therapy for lung disease - March 17th, 2015
- The New Botox: Stem Cell Therapy Cream Reviews - Video - March 14th, 2015
- Miracle stem cell therapy reverses multiple sclerosis - Video - March 14th, 2015
- Cell Therapy - American Cancer Society - March 14th, 2015
- Hip and shoulder arthritis six months after bone marrow stem cell therapy by Harry Adelson ND - Video - March 13th, 2015
- Stem Cell Research & Therapy | Full text | Amnion-derived ... - March 13th, 2015
- High-Dose Immunosuppressive Therapy and Autologous ... - March 13th, 2015
- Biotech Stock Mailbag: Neuralstem, Genfit, Intercept, Amarin - March 13th, 2015
- UCLA Research Shows Promising Method For Correcting Genetic Code To Treat Sickle Cell Disease - March 12th, 2015
- Stem Cell Therapy Cream - Video - March 9th, 2015
- Hello Doctor - Information about Stem Cell Therapy - [Ep 76] - Video - March 9th, 2015
- Okyanos Stem Cell Therapy Launches Orthopedic Lifestyle Survey - March 9th, 2015
- Alternative Treatments For COPD - FAT STEM CELL THERAPY in Dallas, Texas - Video - March 8th, 2015
- Shoulder Labral Tear Repair Using Stem Cell Therapy - Orthopedic Surgeon, Dr. Wade McKenna - Video - March 7th, 2015
- What Is Stemnexa Stem Cell Therapy For Orthopedics And Is It Safe? - Video - March 7th, 2015
- What Is AlphaGEMS Amniotic Tissue Product And How Does It Augment Bone Marrow Stem Cell Therapy? - Video - March 7th, 2015
- Regenerative Medicine | Graziella Pellegrini - Video - March 7th, 2015
- Regenerative Stem Cell Therapy - Video - March 7th, 2015
- Orthopedic Stem Cell Therapy From Bone Marrow - Video - March 6th, 2015
- Using Stem Cell Therapy to Repair Damaged Tissue from Shoulder Impingement Syndrome - Video - March 6th, 2015
- Overcoming Knee Replacement Surgery Faster Using Amniotic Tissue-Enhanced Stem Cell Therapy - Video - March 6th, 2015
- Stem Cell Therapy for Bone Fractures - Board-Certified Orhopedic Surgeon, Wade McKenna DO - Video - March 6th, 2015
- stem cell therapy helps avoiding knee surgery - Video - March 6th, 2015
- Knee arthritis one year after stem cell therapy by Harry Adelson, N.D. - Video - March 6th, 2015
- Stem Cell Therapy in Osteo Arthritis Knee - Video - March 6th, 2015
- Stem Cell Therapy | Simple way to regrow cartilage - Video - March 6th, 2015
- Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas ... - March 6th, 2015
- Shoulder/Hip torn labrum 2 years and 5 months (respectively) after stem cell therapy by Adelson - Video - March 1st, 2015
- 'Miracle' stem cell therapy reverses multiple sclerosis - March 1st, 2015
- Animal cells for a younger you - February 28th, 2015
- Stem cell therapy a boon to Parkinson's patients - February 26th, 2015
- Stem cell therapy a boon for Parkinson patients - February 26th, 2015
- Rowan Researcher Targets Stem Cell-Based Therapy for Rare Childhood Disease - February 25th, 2015
- Stem Cell Research & Therapy | Full text | Aromatic ... - February 24th, 2015
- Stem Cell Therapy for Liver Failure Cirrhosis Kidney Damage - 6 Months After Stemcell Transplant - Video - February 21st, 2015
- Stem Cell Therapy Using Fat Cells - Howard Beach, Ozone Park, Queens NY - Dr. Benjamin Bieber, MD - Video - February 20th, 2015
- Ryan Benton Discusses Stem Cell Therapy for Duchenne's Muscular Dystrophy - Video - February 20th, 2015
- Stem Cell Therapy Using Bone Marrow - Howard Beach, Ozone Park, Queens NY - Dr. Benjamin Bieber, MD - Video - February 20th, 2015
- Dr Ellis hosts seminar on Stem Cell Therapy & Facial Rejuvenation - Video - February 18th, 2015
- Dr. Raj at Beverly Hills Orthopedic Institute Achieving 80% Success with Stem Cell Therapy - February 17th, 2015
- FAQ Part 1: MEsenchymal Stem cell therapy for CAnadian MS patients (MESCAMS) - Video - February 14th, 2015
- Stem Cell Therapy for Erectile Dysfunction - Alvarado Hospital - Video - February 14th, 2015
- How about Stem Cell Therapy for LBD, Nova Cells Institute stem cells - Video - February 14th, 2015
- Cell Therapy Report 2014-2020 - Technologies, Markets and Companies - February 10th, 2015
- Cell Therapy may have just raised $1M, but will crowdfunding have a lasting place in biotech? - February 10th, 2015
- FAQ Part 4: MEsenchymal Stem cell therapy for CAnadian MS patients (MESCAMS) - Video - February 9th, 2015
- Neck and Shoulder arthritis two years after stem cell therapy by Harry Adelson, N.D. - Video - February 6th, 2015
- Okyanos Cell Therapy Success Brings Hope for a Normal Life - February 5th, 2015
- Florida Panther Receives Cutting Edge Stem Cell Procedure from MediVet Biologics - February 5th, 2015