StemCell Therapy

OBJECTIVE:

This study aimed to longitudinally evaluate the association betweenrheumatoid arthritis(RA) and locomotive syndrome (LS) in RA patients using the 25-question Geriatric Locomotive Function Scale (GLFS-25).

Subjects were 58 RA patients (female, 48 (82.8%); mean age, 60.910.9 years) who had GLFS-25 scores available for five consecutive years and who did not have LS at baseline (i.e., GLFS-25<16 points). Associations between DAS28-CRP and the development of LS were determined using linear regression analysis and receiver operating characteristic (ROC) curve analysis.

Subjects were divided into the LS group (n=15, GLFS-2516 points) and Non-LS group (n=43, GLFS-25<16 points) based on GLFS-25 scores at the 5th year of the study period. In the LS group, DAS28-CRP worsened every year. The linear regression model adjusted for age and sex revealed that GLFS-25 increased by 3.80 (95% confidence interval: 1.81-5.79) each time DAS28-CRP increased by 1 (p<0.001). Among patients in remission (DAS28-CRP <2.3), 13.5% had LS. ROC curve analysis yielded a five-year mean DAS28-CRP of 1.99 (sensitivity, 86.7%; specificity, 62.8%) as the cut-off point for the development of LS.

Tight control of RA disease activity for deeper remission may be needed to prevent the development of LS.

Read the rest here:
Relationship between disease activity of rheumatoid arthritis and development of locomotive syndrome: A five-year longitudinal cohort study - DocWire...

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