StemCell Therapy

OBJECTIVE:

Periarticular osteophyte formation is observed during the repair of damaged joints in rheumatoid arthritis (RA); however, little is known about its clinical and functional roles. This study aimed to determine the influence of periarticular osteophyte formation on the incidence oftotal knee arthroplasty(TKA) (a surrogate for long-term outcomes of joint destruction) in patients with RA.

This retrospective longitudinal study included atotalof 130 symptomatic (tender and/or swollen)kneejoints in 80 patients starting biologics. Cumulative incidences of TKA were compared according to the presence or absence of osteophyte on plain anteroposterior radiograph (osteophyte ()) and the extent of advanced joint damage as defined by Larsens grading system (0-II vs. III-V).

Kaplan-Meier estimates showed a significantly lower cumulative incidence of TKA for the osteophyte (+) group (n=33) compared with the osteophyte (-) group (n=31) in the Larsen grades III-V group (38 vs. 74% at 10years, P=0.010), whereas no significant difference was observed between the osteophyte (+) (n=11) and osteophyte (-) (n=55) groups in the Larsen grades 0-II group (9 vs. 10% at 10years). Multivariate Cox proportional hazards analysis revealed that older age (hazard ratio (HR), 1.04 per 1year; 95% confidence interval (CI), 1.01-1.08) and osteophyte formation (HR, 0.39; 95% CI, 0.19-0.79) independently predicted TKA in the Larsen grades III-V group, whereas none of the assessed variables predicted TKA in the Larsen grades 0-II group.

Osteophyte formation reduces the incidence of TKA in patients with RA who have advanced joint damage.Key Points Older age and Larsen grade were independent predictors oftotal knee arthroplasty(TKA) in rheumatoid arthritis (RA) patients. Periarticular osteophyte formation reduced the incidence of TKA in RA patients with Larsen grades III-V.

Continued here:
Periarticular osteophyte formation protects against total knee arthroplasty in rheumatoid arthritis patients with advanced joint damage - DocWire News

This entry was posted on May 19, 2020 at 5:45 pm and is filed under Arthritis. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed. |