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TaiGen Biotechnology Announces Submission of New Drug Application for Taigexyn Intravenous Formulation to the … – PR Newswire (press release)

May 30th, 2017 11:41 am

TAIPEI, Taiwan, May 30, 2017 /PRNewswire/ --TaiGen Biotechnology Company, Limited ("TaiGen") today announced that it has submitted a New Drug Application (NDA) for the intravenous formulation of Taigexyn (Nemonoxacin) to the China Food and Drug Administration (CFDA). Taigexyn is a novel non-fluorinated quinolone antibiotic.The NDA submission is supported by a pivotal Phase 3 trial comparing intravenous formulations of Taigexyn 500 mg to levofloxacin 500 mg in 518 patients with moderate to severe community-acquired pneumonia. The clinical success rates were 91.8% for Taigexyn vs. 85.7% for levofloxacin and Taigexyn was shown to be non-inferior to levofloxacin meeting the primary endpoint of the pivotal trial.

About Taigexyn Taigexyn is a novel broad spectrum antibiotic with excellent efficacy against drug-resistant bacteria available in both oral and intravenous formulations. The oral formulation is already approved for marketing and launched in Taiwan and mainland China. In addition, Taigexyn is also partnered in Russia, Commonwealth Independent States, Turkey, Mexico, Brazil and the Latin American territory for a total 32 countries worldwide.

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Earnings Clues on Puma Biotechnology, Inc. (PBYI), AGNC Investment Corp. (AGNC) Analyst’s Predictions – StockNewsJournal

May 30th, 2017 11:41 am

The Cerbat Gem
Earnings Clues on Puma Biotechnology, Inc. (PBYI), AGNC Investment Corp. (AGNC) Analyst's Predictions
StockNewsJournal
Investors who are keeping close eye on the stock of Puma Biotechnology, Inc. (NASDAQ:PBYI) established that the company was able to keep return on investment at -163.88 in the trailing twelve month while Reuters data showed that industry's average ...
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Puma Biotechnology, Inc. (NasdaqGS:PBYI): Honing in on the TechnicalsGeneva Journal
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Aspen Investment Management Inc Buys 15 Shares of iShares NASDAQ Biotechnology Index (IBB) – The Cerbat Gem

May 30th, 2017 11:41 am

The Cerbat Gem
Aspen Investment Management Inc Buys 15 Shares of iShares NASDAQ Biotechnology Index (IBB)
The Cerbat Gem
iShares NASDAQ Biotechnology Index logo Aspen Investment Management Inc raised its stake in iShares NASDAQ Biotechnology Index (NASDAQ:IBB) by 0.7% during the first quarter, according to its most recent Form 13F filing with the SEC.
Texas Yale Capital Corp. Continues to Hold Stake in iShares NASDAQ Biotechnology Index (IBB)BBNS

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Arthritis symptoms – CURE on the horizon for this painful condition – Express.co.uk

May 30th, 2017 11:41 am

GETTY

The condition is three more times as common in men than women and symptoms tend to develop gradually, sometimes over many years.

Ankylosing spondylitis causes back pain, stiffness, fatigue and impaired mobility that develops over time.

There is no cure for AS at the moment, however experts have announced a new breakthrough which could help sufferers.

New research has revealed an insight into the genetic causes of ankylosing spondylitis that could aid the future treatment of the disease.

GETTY

A study by the University of Oxford has found that the specific genetic variants associated with the onset of the condition may be more common than previously thought.

Data on 213 ankylosing spondylitis patients and 46 people with rheumatoid arthritis was analysed in order to examine the common scientific assumption that ankylosing spondylitis is mostly associated with unusual genotypes called ERAP1.

Two genes involved in antigen processing and presentation to the immune system - HLA-B27 and ERAP1 - have a big role to play in driving the disease.

Previously studies have indicated that rare ERAP1 variants are responsible for the condition.

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Ankylosing spondylitis is known to have a significant genetic link

However experts found that it was in fact common variants of ERAP1 that were responsible for regulating people's ankylosing spondylitis, rather than rare variations or unusual genetic combinations.

The causes of the disease are not currently well understood, so further research into its genetic origins could make it easier for scientists to create new and more effective therapies.

The researchers said the findings have potential implications for future studies addressing the development of ERAP1 inhibitors as new treatments, 'not only for ankylosing spondylitis but also in other diseases genetically associated with ERAP1'.

Dr Katherine Free, research engagement manager at Arthritis Research UK, said: "Ankylosing spondylitis is known to have a significant genetic link, and studies to date have identified over 40 genetic changes that are thought to contribute to an individual's risk of developing this disease.

GETTY

"Previous research has shown that alterations within two particular genes, known as HLA-B27 and ERAP1, have a particularly strong link to ankylosing spondylitis.

This research sheds new light on the particular genetic changes within ERAP1 that are responsible for disease development.

Identifying the effect that these genetic changes have on the immune system could pave the way for the development of new and more effective treatments for this condition."

The research was published in the Proceedings of the National Academy of Sciences. Does arthritis really get worse in winter?

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Maharashtra HSC results today: Mumbai teen fights rheumatoid … – Hindustan Times

May 30th, 2017 11:41 am

Battling severe rheumatoid arthritis, a condition usually associated with the elderly, Ved Ahinave, a 17-year-old from Mumbai, scored 61.23% in the Higher Secondary Certificate (HSC) exams.

The results were declared at 1pm.

Ved wrote his exams without a writer, despite swelling and pain in his joints. He scored 66 marks in English and 77 marks in information technology.

My hands and legs started to hurt because of the strain, but I took frequent breaks and completed the paper, said the student of Swami Vivekananda International School and Junior College, Kandivli. I am happy with my score, I I want to work in the IT sector, just like my parents. I love computers, said Ved.

The 17-year-olds is a rare case.

Ved was diagnosed with arthritis when he was six. The disease is common among people in their late 40s and 50s. It causes the bodys immune system to attack the joints, leading to inflammation and thickening of tissues. His condition worsened when he was in Class 10.

Constant consumption of medicines mostly steroids and painkillers however stunted his growth, said his mother, Seema. He is 17, but is three feet and five inches tall, Seema said, adding they dont know what caused the disease.

Doctors tell me it could be because of low haemoglobin levels during my pregnancy. Some say it is genetic, said the mother.

Ved couldnt get a writer as the board refused to acknowledge his illness. We submitted medical certificates, including one from Sir JJ Hospital. But the board doesnt have provisions for arthritis, said his father Vishwas, 46, an electronics engineer. He used to succumb to bouts of depression, but my friend kept him motivated. His teachers, especially Miss Leena, helped him a lot.

There is no permanent cure for Veds disease. He is learning to live with it. He spends his time configuring phones. We think it can be a good profession if he gets to work from home, his mother said.

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Older adults might be able to stave off arthritis knee pain with fiber … – Fox News

May 30th, 2017 11:41 am

Older people who eat the most fiber are at lower risk of developing knee pain and stiffness due to osteoarthritis (OA), new research shows.

Diets rich in fiber from plant-based foods have clear health benefits, such as lower cholesterol, better-controlled blood sugar, and a healthier weight, but most people in the U.S. don't eat enough fiber, lead author Dr. Zhaoli Dai of Tufts University in Boston told Reuters Health.

The current average fiber intake among U.S. adults is about 15 grams, she noted. "This is far below the recommended level, which is 22.4 grams for women and 28 grams per day for men 51 years and above," Dai said.

SEVERAL NON-DRUG OPTIONS HELP WITH FATIGUE DURING, AFTER CANCER TREATMENT

OA, which occurs when wear and tear on the joints degrades cartilage and leads to bone abnormalities, is extremely common in people 60 and older. It can be painful, and is also a leading cause of disability. There is no treatment for OA, aside from joint replacement, and therapies to address symptoms, such as anti-inflammatories for pain and swelling.

Given that dietary fiber is known to help prevent obesity and reduce inflammation, both of which are associated with arthritis, Dai's team looked at diet and arthritis risk over time in two study groups. In the Osteoarthritis Initiative, which included 4,796 men and women with OA or at risk for OA, people who consumed the most dietary fiber at the start of the study were 30 percent less likely than those who ate the least fiber to develop knee pain, stiffness or swelling due to OA, or to worsening of OA, during four years of follow-up.

In the Framingham Offspring Study, which included 1,268 adults in their early 50s, on average, the top quarter of fiber consumers had a 61 percent lower risk of knee OA symptoms nine years later than the bottom quarter.

SOUTH DAKOTA TEEN WITH BRAIN CANCER GIVEN OK TO WALK AT GRADUATION

There are many mechanisms through which increased fiber intake could help ease knee arthritis symptoms, Dai said, for example by reducing inflammation and helping people to maintain a healthy weight. Fiber can also act as a pre-biotic, she added, meaning that it can help fuel the growth of beneficial microbes in the gut, which in turn also reduces inflammation.

"This is the first study to show that consuming more dietary fiber is related to lower risk of painful knee osteoarthritis," Dai said. "Changing diets by increasing intake of dietary fiber seems to be one of the most economic ways to reduce the risk of knee osteoarthritis."

Older adults, especially those who are overweight or obese, should consider increasing their fiber intake, she added.

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Global Psoriatic Arthritis Biosimilars Market Access Report 2017 – GlobeNewswire (press release)

May 30th, 2017 11:41 am

May 30, 2017 05:15 ET | Source: Research and Markets

Dublin, May 30, 2017 (GLOBE NEWSWIRE) -- Research and Markets has announced the addition of the "Biosimilars Market Access in Psoriatic Arthritis" report to their offering.

Tumor necrosis factor (TNF)-alpha inhibitors Enbrel, Humira, and Remicade have long held dominant positions in the psoriatic arthritis market. These market leaders, however, face patent expirations and consequent biosimilar launches.

Payers are eager to leverage these changes in the competitive landscape and enact pro-biosimilar access measures, resulting in downward pricing pressures and/or continuing market erosion for first-generation TNF-alpha inhibitors.

The rate of this erosion is likely to be gradual initially, as both physicians and payers are not likely to advocate patient switching.

Key Topics Covered:

1. Executive Summary

2. Five Major EU Markets

3. Methodology

For more information about this report visit http://www.researchandmarkets.com/research/bczl5n/biosimilars

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Nottingham student designs saucepan to help elderly people with arthritis stay independent – Nottingham Post

May 30th, 2017 11:41 am

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A saucepan to help elderly people with arthritis keep their independence has been designed by a Nottingham student and the inspiration behind the idea was her grandparents.

Emma Bucknell, a product design student at Nottingham Trent University, designed the saucepan to make cooking more comfortable for people who have arthritis in their fingers, hands and wrists.

It has been made with a plastic handle on one side so you can slide your hand through it, meaning the saucepan can be lifted using the strength in the arm rather than in the hand.

Originally from Hertfordshire, Emma said she came up with the idea for her product after seeing her own grandparents struggle with debilitating disease.

The 21-year-old said: "I know from my grandparents that arthritis is a painful and uncomfortable condition. My nan struggles with lifting saucepans so I took the opportunity to find a solution to help them."

The design of the handle aims to reduce the weight and pressure that is put on people's fingers and hands when they lift the heavy pans, which traditionally have straight handles.

During her research into arthritis Emma said she discovered that long thin handles can be a problem for people who have the condition or a weak grip, because the hand has to form an unnatural position while holding on to them.

The newly-designed pan is made out of aluminium so it is light to hold and the handle is designed to fit a wide range of different sized hands for comfortable use.

On the other side is a spherical handle which people can hold, to evenly distribute the weight of the saucepan when using both hands.

Emma added: "I can see that arthritis does not just affect a person with its painful symptoms, it affects their whole life. What many people would see as a simple task, can become difficult and sometimes impossible for those with the condition.

"This can destroy independence; the one thing elderly and retired people desire to keep."

According to Arthritis Care around 10 million people suffer from arthritis in the UK.

James Dale, principal lecturer in product design at Nottingham Trent University, said: "Emma has seen first-hand how difficult it can be for people with arthritis to carry out tasks such as cooking and she has used this experience to create a product that could improve people's confidence and independence.

"The saucepan has the potential to go beyond the elderly market and reach others who have the same condition"

Emma's saucepan is set to go on show at the university's Degree Show from June 3 to June 10 at the City Campus.

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Toddler eye problems you may not know about – Channel NewsAsia

May 29th, 2017 2:45 am

SINGAPORE: When you were younger, your parents would nag at you not to sit too close to the television, or to refrain from reading in the dark, so as not to get myopia in the future. You may find yourself singing the same tune to your kids now. With some 40 per cent of adult Singaporeans suffering from myopia or short-sightedness - one of the worlds highest - its an eye problem many of us are familiar with. Yet, children also suffer from lesser known eye problems.

Stresses senior consultant ophthalmologist Dr Leo Seo Wei, Early diagnosis and treatment are critical to maintaining your childs eye health as many diseases can result in lazy eye or amblyopia, which can cause loss of vision if not treated in time.

So, be vigilant about your mini-mes eye health as acting early might help save your childs eyesight. Read on to learn more about other eye problems junior could suffer from, as well as their symptoms and the treatments available.

STRABISMUS In strabismus, more commonly known as squinting, your childs eyes are misaligned and dont look in the same direction. Babies usually have this problem as their eye muscles are not strong enough to hold the eyeball in a fixed position for long. However, if your babys eye condition persist for months, bring him to the doctor for a check.

What to look out for: Misaligned eyes, eyes that move differently, squinting or closing one eye in the presence of bright light or sunlight, or double vision.

Treatment: In very mild cases, wearing spectacles should straighten out the eye. If not, eye patches or atropine eye drops can also be used. These work by covering or blurring the good eyes vision, forcing the weaker eye to work harder, which strengthens the muscles. As a last resort, surgery might be needed to help loosen or tighten the muscle of the eye.

AMBLYOPIA Amblyopia or lazy eye occurs when the vision of one eye is significantly better than the other and the brain begins to rely on the better eye and ignore the weaker one, Dr Leo explains. If lazy eye is not treated, the brain might start to ignore the images from the weaker eye in the long run, which will have a permanent impact on juniors vision. Lazy eye can be caused by a droopy eyelid or a cataract, which obstructs or disrupts vision. Strabismus can also cause lazy eye as the eyes do not line up as it should, causing blurry vision. Some parents may find it hard to spot amblyopia in their kids as their eyes are well aligned.

What to look out for: Poor vision in one or both eyes, squinting or tilting the head to see, poor depth perception or complains of headaches.

Treatment: Spectacles are worn to correct the sufferers vision. The use of eyepatches and atropine eye drops will also force the brain to pick up images from the weaker eye, instead of relying solely on the good eye. Finally, surgery can tighten or loosen the eye muscle, correct a droopy eyelid or remove the cataract that is interfering with your kids vision.

EPIBLEPHARON Epiblepharon is a congenital condition whereby there is an extra horizontal fold of skin near the upper or lower eyelid margin. Normal eyelashes point forward but people with this irregularity find that their eyelashes are pushed against their cornea. Most commonly found in Asian children, this condition will mostly disappear over time when they mature because their facial features change.

What to look out for: Red, itchy and teary eyes. Constant rubbing of the eyes.

Treatment: In mild cases, lubricating eye drops or ointment can be used to treat this condition. In severe cases, surgery might be needed to remove a small area of excess skin and muscle to allow the lashes to point outwards.

RETINOBLASTOMA Retinoblastoma, a form of cancer that grows in the retina, is usually only found in children. This cancer affects foetuses in the mums womb, up till the age of 5. If detected in utero, a foetus with retinoblastoma can be delivered early to initiate early treatment, which can reduce the rate of the disease and help preserve the vision, explains Dr Leo. If treated early, up to 95 per cent of retinoblastoma sufferers can be cured.

What to look out for: A cloudy white pupil or reddish pupil, accompanied with pain and discomfort. The pupil may look larger than normal, the irises have different colours and vision may be poor or reduced.

Treatment: The most common treatment method is chemotherapy oral or through injections or external beam radiation. Radiation is carefully focused onto the tumour to kill cancer cells. Other methods are brachytherapy (insertion of radioactive implants into the disease), cryotherapy (freezing treatment), and lastly, enucleation (removing the entire eyeball). Pointing out that retinoblastoma treatment should be tailored to each individual, Dr Leo adds, The treatment type depends on factors such as location and size of the tumour, and the estimated vision prognosis.

GLAUCOMA In glaucoma, increased pressure in the eyeball can lead to blindness if left untreated. A rare condition thats usually diagnosed within the first year of an infants life, Dr Leo says that most paediatric cases of glaucoma have no specific cause and are considered primary glaucoma. Secondary glaucoma happens when it is caused by, or associated with a specific condition such as aniridia (absence of the iris), trauma or previous eye surgery like childhood cataract removal.

What to look out for: Excessive tearing and blinking, enlarged or bulging eyes, red and irritated eyes, cloudiness of the cornea or sensitivity to light.

Treatment: Most cases of primary paediatric glaucoma are treated with surgery. Other methods include laser and eye drops. Although rare, eye drops might have systemic side effects on children. The younger and lower the body weight, the higher the risk, Dr Leo notes.

COATS DISEASE This happens when blood vessels carrying oxygen and blood to the retina break, leaking fluid and causing a build-up of fatty material in the retina, causing it to swell, which results in either partial or complete detachment of the retina. Dr Leo states that this is a very rare disease she only sees about one patient with Coats Disease per year. Early detection will save your eyesight but if it has already progressed to the final stage, the eyeball might need to be removed.

What to look out for: Yellow eye when a picture with flash is taken, loss of depth perception and parallax (position/direction of an object appears to differ when viewed from different positions). The eyesight worsens (either central or peripheral vision).

Treatment: Dr Leo says, Laser or cryotherapy are utilised to constrict the abnormal blood vessels and stop the leakage of fluid. Surgery might be needed in the advanced stages of the disease to treat retinal detachment. After treatment, the patient will be monitored to ensure that the disease does not return.

Dr Leo Seo Wei is the medical director and senior consultant ophthalmologist at Dr Leo Adult and Paediatric Eye Specialist.

This story first appeared on SmartParents

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Shingles of the eye – Trinidad & Tobago Express

May 29th, 2017 2:45 am

Two types of Herpes viruses are involved in infections of the eye. 1. Herpes Zoster, and 2. Herpes Simplex type I. Of these Zoster or Shingles is the more dramatic, causing pain, swelling and a vesicular rash consisting of fluid-filled blisters around the eye and forehead. Direct involvement of the eye results in redness, glare sensitivity and blurred vision. Shingles is due to a reactivation of the virus in persons previously exposed. It is usually seen in older persons who were affected by the virus in their younger days when it manifested as chicken pox. After first exposure the virus remains inactive in sensory nerves. Reactivation is associated with exposure to someone with chicken pox or shingles or when ones resistance is low eg debilitating diseases, cancer chemotherapy etc. Shingles may affect other parts of the body like the chest and abdomen. When the sensory nerve supplying pain to the forehead, temple and eye (the ophthalmic branch of the trigeminal nerve) is involved then HZO results. HZO should be considered an emergency, as severe consequences may result. These include severe chronic pain and vision loss. In order to ensure proper follow-up and to reduce suffering and risk of vision loss, early diagnosis, prompt and appropriate treatment is extremely important. Diagnosis may be difficult in the early (prodromal) stage before the rash appears. At this stage the patient experiences fever, malaise, headache, and eye pain prior to eruption of the skin rash. A history of recent exposure to chicken pox or shingles, chemotherapy and aged over 60 should raise concern. One should seek medical attention as soon as the rash appears because the disease can be arrested and unpleasant complications avoided. Sometimes a single vesicle or boil is observed and this may be neglected for several days until symptoms get worse. Occasionally HZO presents as an isolated inflammation of the eye that is difficult to distinguish from other more benign causes of a red eye - conjunctivitis. A vesicle present at the tip of the nose is a sign that the cornea and inner structures of the eye may be involved. This will result in prolonged inflammation associated with grittiness, watering, glare sensitivity, blurred vision and eye pain. Consequences include chronic eye pain, dry eyes, recurrent infection or inflammation, corneal scarring, cataract, glaucoma and loss of sight. Risk

You are at increased risk of getting shingles if you: Had chickenpox as a child Are age 60 or older because your immune system weakens as you age Have a weakened immune system because of a disease like cancer, HIV infection, or AIDS Take medicine that weakens your immune system, such as chemotherapy or radiation for cancer

Prevention: Varicella-Zoster Shingles vaccination in patients over the age of 60 appears beneficial in reducing the rate of HZO.

Can Shingles be spread? Shingles cannot be passed from one person to another. However, the virus can be spread from a person with active shingles to another person who has never had chicken pox. In such cases, the exposed person might develop chicken pox, but they would not develop shingles. The virus is spread through direct contact with fluid from the blisters caused by shingles. A person is not infectious before the blisters appear and once the rash has developed crusts, the person is no longer contagious. Shingles is less contagious than chickenpox and the risk of a person with shingles spreading the virus is low if the rash is covered.

If you have shingles: Keep the rash covered. Avoid touching or scratching the rash. Wash your hands often to prevent the spread of varicella zoster virus. Until your rash has developed crusts, avoid contact with Pregnant women Premature or low birth weight infants and People with weakened immune systems, such as people receiving immuno-suppressive medications or undergoing chemotherapy, organ transplant recipients, and people with human immunodeficiency virus (HIV) infection. Treatment

Shingles of the eye must be treated by an ophthalmologist. Other members of the medical team, depending on the severity, may include a dermatologist and neurologist. Medications will include antiviral drugs, pain killers, steroidal and non-steroidal anti-inflammatory medications, antibiotic eye preparations and topical applications to the skin. Surgery may be required to deal with complications such as corneal scarring. Presented as a public service by the Caribbean Eye Institute. Please email all eye-related concerns to Caribeyett@icloud.com

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Kidneys from deceased diabetes patients may be organ donation source – CBS News

May 29th, 2017 2:44 am

People who received kidneys from non-living donors with diabetes were less likely to die than those who stayed on the wait-list.

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Kidneys from deceased diabetic donors can save the lives of patients on the transplant wait-list, researchers say.

For the study, investigators compared U.S. data from more than 8,100 recipients of kidneys from deceased donors who'd had diabetes with data from people on the kidney transplant wait-list. The patients were followed for an average of nearly nine years.

People who received kidneys from diabetic donors were 9 percent less likely to die during that follow-up period than those who were still on the wait-list or were seeking a kidney from a non-diabetic donor, the study found.

The people who benefited most from diabetic donor kidneys were those who were most likely to die while on the wait-list, the researchers said.

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But poor-quality kidneys from deceased diabetic donors did not improve survival chances, the findings showed.

And people under age 40 didn't benefit from diabetic donor kidneys, according to study author Dr. Jordana Cohen. She is an instructor at the University of Pennsylvania Perelman School of Medicine.

More than 100,000 people are on the U.S. kidney transplant wait-list. The study findings suggest that kidneys from deceased diabetic donors may help relieve the shortage of organs.

"As kidney disease has become increasingly common in the United States over the past few decades, the need for kidneys to be donated far exceeds the number of available kidneys," Cohen said in an American Society of Nephrology news release.

"As a result, poorer-quality kidneys are increasingly being used as a way to try to decrease transplant waiting times and thus decrease the number of people who die while waiting for a kidney transplant," she explained.

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The study was published online May 25 in theClinical Journal of the American Society of Nephrology.

The author of an accompanying editorial, Dr. Richard Formica Jr., said the study findings support the use of deceased-donor kidneys that would likely be discarded.

"However, as important as this finding is," Formica said, "it is necessary to view it in the context of the larger problem facing the nephrology community as it struggles to care for patients with end-stage renal disease."

Formica, a professor and director of transplant medicine at Yale University School of Medicine, said that only a fraction of money spent to treat end-stage kidney disease goes to kidney transplantation, even though it is better than dialysis and costs less.

"It is unfortunate that despite spending 17.4 percent of its [gross domestic product] on health care, the United States does not focus more of its resources on solving the problem through increasing access to kidney transplantation," he concluded.

2017 HealthDay. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.

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Puma Biotechnology (PBYI) Earns Media Sentiment Score of -0.01 – The Cerbat Gem

May 29th, 2017 2:41 am

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Puma Biotechnology (PBYI) Earns Media Sentiment Score of -0.01
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Link between obesity and arthritis – Ten Eyewitness News

May 29th, 2017 2:41 am

With Arthritis Awareness Week kicking off on Sunday, Medibank Better Health Index have released new data which outlines the concerning rise of osteoarthritis, and links between the condition and obesity.

Over the last nine years, the number of Australians living with osteoarthritis has increased from 6.2 to 8.5 per cent, which is equal to more than half a million additional cases.

The findings show the incidence of the condition has grown in line with the national trend towards obesity -- with 28.4 per cent of Australians falling into the obese Body Mass Index (BMI) category, compared to just 25.2 per cent in 2007.

Its an alarming trend given the already astute issues surrounding obesity in the country, and how much it is costing our healthcare system.

Medibank Chief Medical Officer Dr Linda Swan said the data should come as a wake-up call to Aussies.

Its concerning to see that the incidence of osteoarthritis is continuing to climb year-on-year, with almost one in ten Aussies now living with the condition.

We know osteoarthritis can be exacerbated by being overweight or obese, so its essential that we continue to encourage healthy eating habits and regular exercise as these can help both prevent and improve osteoarthritis symptoms.

While generally any type of activity is good, people's health risks can vary, so consulting your GP about the type of exercise that's right for you is always a wise step, Dr Swan said.

In South Australia alone, there are 124,000 patients living with osteoarthritis, 33,000 more than in 2007.

These findings support the need for ongoing research into osteoarthritis -- which the Medibank Better Health Foundation is committed to. Through this research, we aim to help those affected by musculoskeletal conditions improve their quality of life, and better understand, prevent and manage the condition, Dr Swan said.

In releasing the data, Medibank also provided some tips for preventing and managing osteoarthritis.

Keep Moving, safely: Exercise is vital in both managing the condition, and preventing it, as regular exercise helps to strengthen muscles and joints. There is a warning, however, not to overdo it. Too much exercise can cause injury and put an unnecessary stain on joints.

Follow a healthy diet: With obesity one of the leading causes of osteoarthritis, its extremely important to maintain a healthy, well0-balanced diet to maintain a healthy weight.

Opt for supportive footwear: Medibank writes thats having the right show means having the required support to carry your body. They recommend speaking to a podiatrist about choosing the appropriate footwear.

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Promising Results for Drug for Psoriatic Arthritis – WebMD

May 29th, 2017 2:41 am

By Randy Dotinga

HealthDay Reporter

FRIDAY, May 26, 2017 (HealthDay News) -- A new drug might help ease the pain and disability of a form of arthritis often linked to psoriasis.

According to Stanford University researchers, psoriatic arthritis is an inflammatory joint disorder tied to an out-of-control immune response. The disease affects about one in every 200 people and is often accompanied by the autoimmune skin disorder psoriasis.

Psoriatic arthritis typically arises after the age of 30 and can bring stiffness, pain and swelling of the joints, leading to real disability if treatments don't help.

The new study focused on more than 300 adult patients across 10 countries. These patients were no longer seeing an effect from standard biologic drugs or had never experienced a benefit in the first place.

That's not uncommon.

"Only about half of psoriatic arthritis patients who are given TNF inhibitors get better," study lead author Dr. Mark Genovese said in a Stanford news release.

So, his team tried out a newer drug called Taltz (ixekizumab), already approved to fight psoriasis. The study was funded by the drug's maker, Eli Lilly & Co.

Patients were randomly assigned to receive injections of either Taltz or an inactive placebo. Over 6 months, about one-third got Taltz injections every two weeks, another third received the placebo every two weeks, while the remaining third received alternate injections of Taltz and the placebo.

More than half (53 percent) of those treated with the drug experienced at least a 20 percent reduction in the number of tender and swollen joints, compared to about 20 percent of those receiving the placebo, said Genovese. He's a professor of immunology and rheumatology at Stanford University Medical Center.

One expert in psoriatic arthritis was encouraged by the findings.

Taltz "is another new option for patients with psoriatic arthritis," said Dr. Waseem Mir, a rheumatologist at Lenox Hill Hospital in New York City. "The data shown in this article supports that certain patients who do not do well with other biologics that are in the market for psoriatic arthritis will now have another option for treatment of their painful disease," he said.

One potential side effect of these immune-focused drugs is a heightened vulnerability to infectious disease. However, Genovese said there was little difference in this regard between people taking Taltz and those on a placebo.

The study was published online May 24 in The Lancet.

WebMD News from HealthDay

SOURCES: Waseem Mir, M.D., rheumatologist, Lenox Hill Hospital, New York City; Stanford University School of Medicine, news release, May 24, 2017

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Cheyenne Mountain Zoo makes medical history with ‘giraffe sneakers,’ stem cell treatments – Colorado Springs Gazette

May 29th, 2017 2:40 am

Twiga, a 14-year-old female giraffe with advanced arthritis and osteoporosis in her feet, was fitted with custom shoes. (Photo courtesy of the Cheyenne Mountain Zoo.)

Cheyenne Mountain Zoo appears to have made medical history with its innovative giraffe treatments.

Mahali, a 14-year-old male giraffe who suffered from chronic lameness, is believed to be the first in the world to be injected with stem cells grown from giraffe blood, according to a news release from the zoo.

Stem cell therapy was chosen in the treatments led by Dr. Liza Dadone, the zoo's head veterinarian, because it has proven to repair damaged tissue. Staff at Colorado State University's James L. Voss Veterinary Teaching Hospital in Fort Collins helped with the treatment.

Nearly a month after the procedure, when Mahali was injected with about 100 million stem cells, thermographic images of the giraffe's front legs show "a considerable decline" in inflammation in his front left leg, the leg that had been giving him trouble, the zoo said.

"This is meaningful to us not only because it is the first time a giraffe has been treated with stem cells, but especially because it is bringing Mahali some arthritis relief and could help other giraffes in the near future," Dadone said in a written statement.

Dadone said it's not clear whether the successful results are due only to the stem cell treatment or a combination of treatments.

"Prior to the procedure, he was favoring his left front leg and would lift that foot off the ground almost once per minute," she said in the statement. "During the immobilization, we did multiple treatments that included hoof trims, stem cell therapy and other medications. "Since then, Mahali is no longer constantly lifting his left front leg off the ground and has resumed cooperating for hoof care. A few weeks ago, he returned to life with his herd, including yard access. On the thermogram, the marked inflammation up the leg has mostly resolved."

Twiga, a 14-year-old female giraffe with advanced arthritis and osteoporosis in her feet, was fitted with custom shoes with the help of farriers Steve Foxworth and Chris Niclas of the Equine Lameness Prevention Organization.

"We've had Twiga on medicine to help reverse her osteoporosis, but we wanted to do more to protect her feet. So with the help of the farriers, we gave her 'giraffe sneakers' to help give her some extra cushion," Dadone said in a written statement.

The giraffe's behavior was immediately changed - "Twiga instantly shifted her weight off of her right foot, indicating she was comfortable and her pain had considerably lessened" - but she will likely wear the shoes for about six more weeks, the zoo said.

Giraffes' size can make them more susceptible to issues like arthritis and osteoporosis. "Like all animals, these issues are exacerbated as they age," according to the zoo news release.

The zoo has a herd of 17 giraffes, including a newborn in April. The calf, a girl, was the 199th to be born in the 63-year history of the zoo's breeding program.

Giraffes' status was recently changed from "least concern" to "vulnerable" by the International Union for Conservation of Nature because the population in the wild has decreased by 40 percent in the last 30 years, the zoo said.

-

Contact Ellie Mulder: 636-0198

Twitter: @lemarie

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Home / News / Ottawa Hospital Stem Cell Discovery ‘A… – www.ottawacommunitynews.com/

May 27th, 2017 10:43 pm

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A new stem cell treatment is in development at the hospital, which has the potential to heal the damaged lungs of premature babies, like Olivia. - Erin McCracken/ ... The research team originally thought these would replace the dead lung cells. But ...

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Baywatch’s Cultural Blindness – National Review

May 27th, 2017 10:42 pm

The new Baywatch movie, a reboot of the Nineties beach-set crime-and-melodrama TV series, continues Hollywoods unoriginal marketing. It holds momentary interest for the way it adapts television culture (free, meaningless distraction) for a new era.

On the big screen, Baywatch might seem a variation on its cathode-ray source simply because it stars Dwayne The Rock Johnson, Hollywoods leading exponent of biracial diversity, and Zac Efron, Hollywoods newest male pin-up. Respectively, they play lifeguards Mitch and Matt not entirely interchangeable but alliterative nonentities who bring little distinction to the basic formula. The combination of over-the-top action-movie stunts and crass humor is shameless, both below-the-belt and beneath most folks IQs.

Hollywood movies have become television at just the point when media shills are spreading the fake news that were experiencing a new golden age of TV. These shills dont call it a renaissance, because that word might intimidate victims of our failed education system and even cynics realize that nothing gets reborn in Hollywood, that recycling is not the same as being given new life.

Yet the level of audacity in the Baywatch movie, directed by Seth Gordon with the same insipidness he brought to Identity Thief and Horrible Bosses, is greater than in the cornball TV series. And Johnsons and Efrons exaggerated beefcake and lame ethnic contrasts add to the overkill. Only a child mired in TV cultures hard sell would find any of this unique. Such unenlightened appreciation would be a sign of the cultural catastrophe in which old television shows are granted the same interest that Hollywood used to give to classic drama and literature. This pop-culture emergency is more urgent that the films plot, in which the team of lifeguards oppose a drug dealer (Priyanka Chopra), an idea rehashed from last months movie version of the TV series CHiPs.

What Millennial children and hack reviewers dont admit is that this shift of values, the inevitable triumph of assaults on the cultural canon (the old low- vs. high-culture debate), defines a state of widespread desperation: Hollywood is desperate to make money, without the risk of creativity, and audiences are eager to be distracted from their daily, dangerous, antagonistic, collapsing reality. Baywatch, while offering incessant juvenile sitcom bromides about competition (competence) and sex (relationships), disguises those concerns while making them trite. It plays the audience cheap.

The pandering involved in making a film version of a TV series cravenly calculates the publics taste for T & A and chase scenes. This blatancy is regressive. A Baywatch movie works backward from the Sixties beach-movie series Gidget that then became a TV show. The display of muscle strain during a Rock vs. Zac beach competition is worse than obvious; its not as light-hearted as the beach competition in Dirty Grandpa, and it misses the reality-show tension of Steve Austins Broken Skull Challenge.

If Baywatch were better than junk, it might deserve a semiotic analysis of its leisure-place setting, diversity casting, and smutty premise that devolves into law-and-order banality. But we are at a stage of escapist desperation that a critic has to wonder whether that desperation is worth exposing. Neither Johnsons Mitch nor Efrons Matt shows the depth that might make audiences relate to them as people. (That was the surprise of Johnsons characterization in Michael Bays superb Pain & Gain, in which he played muscle-head psychosis as a symptom of greed and insecurity a modern condition made revelatory and funny.)

It wont do to dismiss Baywatch as the start of the summer inanity (movie inanity is a year-long problem). But consider the beach-movie idea to which Baywatch is historically inferior. Alexander Mackendricks sex farce Dont Make Waves (1967) depicted the edifice of American morality as nearing collapse. In Daniel Petries The Lifeguard (1977), a rare character study of male concupiscence, the casually macho Sam Elliott faces moral obligation. And, best of all, recall Eric Rohmers serene, erotic farce Pauline at the Beach (1983). All dealt with the sexual mores of their times, but TV culture never gets that deep and apparently has not inspired erotic reflection even in a reboot.

There are going to be more and more movies like this, many from TV series, most from comic books. But the lesson that must be learned is that escapism especially when its TV-based amounts to cultural idiocy. Despite its sun-bright carousing, cuss words, and explosions, Baywatch merely takes its cue from TV manipulation of the shut-ins and the adolescents sexual prurience. These hedonistic beach-bunny hijinks are Hollywoods own winking equivalent of the 72-virgins promise that inveigles terrorists.

Armond White is the author of New Position: The Prince Chronicles.

Continued here:
Baywatch's Cultural Blindness - National Review

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Promising Results for Drug to Fight Arthritis Linked to Psoriasis … – Arizona Daily Star

May 27th, 2017 10:41 pm

FRIDAY, May 26, 2017 (HealthDay News) -- A new drug might help ease the pain and disability of a form of arthritis often linked to psoriasis.

According to Stanford University researchers, psoriatic arthritis is an inflammatory joint disorder tied to an out-of-control immune response. The disease affects about one in every 200 people and is often accompanied by the autoimmune skin disorder psoriasis.

Psoriatic arthritis typically arises after the age of 30 and can bring stiffness, pain and swelling of the joints, leading to real disability if treatments don't help.

The new study focused on more than 300 adult patients across 10 countries. These patients were no longer seeing an effect from standard biologic drugs or had never experienced a benefit in the first place.

"Only about half of psoriatic arthritis patients who are given TNF inhibitors get better," study lead author Dr. Mark Genovese said in a Stanford news release.

So, his team tried out a newer drug called Taltz (ixekizumab), already approved to fight psoriasis. The study was funded by the drug's maker, Eli Lilly & Co.

Patients were randomly assigned to receive injections of either Taltz or an inactive placebo. Over 6 months, about one-third got Taltz injections every two weeks, another third received the placebo every two weeks, while the remaining third received alternate injections of Taltz and the placebo.

More than half (53 percent) of those treated with the drug experienced at least a 20 percent reduction in the number of tender and swollen joints, compared to about 20 percent of those receiving the placebo, said Genovese. He's a professor of immunology and rheumatology at Stanford University Medical Center.

One expert in psoriatic arthritis was encouraged by the findings.

Taltz "is another new option for patients with psoriatic arthritis," said Dr. Waseem Mir, a rheumatologist at Lenox Hill Hospital in New York City. "The data shown in this article supports that certain patients who do not do well with other biologics that are in the market for psoriatic arthritis will now have another option for treatment of their painful disease," he said.

One potential side effect of these immune-focused drugs is a heightened vulnerability to infectious disease. However, Genovese said there was little difference in this regard between people taking Taltz and those on a placebo.

The study was published online May 24 in The Lancet.

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Arthritis medication naprelan – Naproxen for arthritis dosage – Naproxen or ibuprofen for rheumatoid arthritis – Utah Political Capitol

May 27th, 2017 10:41 pm

Welcome to the UPC Show with Curtis Haring, Alex Cragun, and Dylan McDonnell. On the show today we talk about the growing fight between the legislature and the governor around a special session to potentially replace Jason Chaffetz, Speaker of

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Welcome to the UPC Show with Curtis Haring and Alex Cragun with special guest Bob Kubichek. On the show today we talk about new signage requirements in bars versus restaurants, Donald Trump looks into Bears Ears, Jim Matheson has gotten

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Welcome to the UPC Show with Curtis Haring and Alex Cragun. On the show today we talkabout Jason Chaffetzs surprise announcement, the rest of the Utah delegation is having poll trouble, Trumps budget has a real impact on Utah, and

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Welcome to the UPC Show with Curtis Haring, Dylan McDonnell,and Alex Cragun. On the show today we talk about some proposed changes to an initiative to fund education, Chris Stewarthas a Democratic challenger, and Orrin Hatch might be on the

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Welcome to the UPC Show with Curtis Haring, Dylan McDonnell,and Alex Cragun. In the first half: UTAs woes and Rocky Mountain Power assumes that EPA regulations will be rolled back. In the second half: An audit shows that sex-offender treatment

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A general expressionof concern about the recent hospitalization of Senator Ralph Okerlund (RepublicanMonroe) was made at the Central Utah Leadership Summit, an annual gathering of elected officials and economic development experts in rural Utah. Public announcementsby both Byron Woodland, Board

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Welcome to the UPC Show with Curtis Haring, Dylan McDonnell,and Alex Cragun. In the first half: Orrin Hatch says he is willing to step asideif someone like Mitt Romney steps in and people booingRepresentative Stewart at a recent town hall

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Welcome to the UPC Show with Curtis Haring, Dylan McDonnell,and Alex Cragun. This week we round out the three part legislative extravaganza by talking about Business, specifically:HB 40 Check Cashing and Deferred Deposit Lending Amendments Brad Daw (Republican

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View other reviews in this series: Agriculture, Air Quality, and Alcohol Business, Campaign Finance, Crime and the Courts Drugs HB 50 Opioid Prescribing Regulations from Representative Ray Ward (Republican Bountiful) If you have been paying attention to public

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First Indy 500 Driver with Diabetes Talks About Racing, Life with His Disease – Healthline

May 26th, 2017 2:45 pm

It all started with a skin rash.

Ten years ago, race car driver Charlie Kimball went to his doctor to check out that small rash on his arm.

In the course of their conversation, the physician learned that Kimball had also been unusually thirsty in recent days.

When he weighed Kimball, the doctor discovered his patient had lost 25 pounds in five days.

He immediately suggested Kimball be tested for diabetes.

Kimball admits he was pretty clueless about the disease. He even asked his doctor if he could prescribe antibiotics for it.

I didnt know what it was or what it involved, Kimball told Healthline.

He soon found out when he was officially diagnosed at age 22 with type 1 diabetes.

Since that time, Kimball has become educated about diabetes.

He has also adjusted his life, both at home and behind the wheel of his race car.

A few years after his diagnosis, Kimball became the first person with diabetes to be allowed to drive in the Indianapolis 500.

On Sunday, he will compete in his seventh Indy 500 race.

As he circles that famed track the required 200 laps, Kimball will have a water bottle and a container of orange juice by his side.

Hell also be watching his blood glucose level on his dashboard.

Read more: Athletes with diabetes to follow on social media

Kimball concedes his diabetes diagnosis was a bit of a shock.

At age 22 you feel 10 feet tall and bulletproof, he said.

Kimball immediately had to start changing his daily routine.

He now takes insulin four times per day. One dose is a long-lasting insulin he takes in the morning. The other three are fast-acting insulin he takes after each meal.

Kimball also watches his diet much more closely.

He has learned that the carbohydrates in pizza, for example, take longer to enter the blood stream than most foods. He learned that corn has carbohydrates, too.

Kimball was initially worried about whether hed be able to continue race car driving.

I was concerned about getting back in my race car, he recalled. The race car is the only place I feel really alive.

That involved more than just driving.

Race car drivers are athletes.

They are handling vehicles without power steering that are traveling around 200 miles an hour.

The stress keeps their heart rate high throughout an entire three-hour race. They can lose seven pounds of water weight due to the heat of the car. And they can burn more than 1,100 calories in a single race.

Im always concerned about the safety element and the performance element, he said.

Kimball quickly learned, however, that his new dietary routine was actually enhancing his skills.

It helps me be a better athlete, he commented.

During his races, Kimball wears special sensors on his skin that monitor his body functions.

On his dashboard, he can monitor his blood glucose level and other health-related data along with his cars speed and how many laps he has completed.

Kimball said it isnt a coincidence hes the first Indy 500 driver with diabetes.

Until recent years, there wasnt the technology to provide enough support and assistance to a driver with this particular condition.

In addition, Kimball said, most people with type 1 diabetes are diagnosed when they are children.

At that stage, most kids with the disease dont envision becoming a race car driver.

Kimball, on the other hand, was already doing it.

I wasnt going to let diabetes get in the way of my lifes dream, he said.

Read more: NASCAR driver getting the word out on colorectal cancer

Kimball hopes his drive to continue his race car career will inspire children and others with diabetes.

He said he wants youngsters to feel like they still can do whatever they want, whether its being an athlete, a rock climber, or a chief executive officer.

I want them to be able to chase their dreams, he said.

Kimball is also participating in a program at Michigan State University to study exercise physiology and race car driving.

David Ferguson, PhD, an assistant professor of kinesiology, oversees the program. Ferguson has been doing this kind of research for 12 years.

When Kimball came along, Ferguson saw an opportunity to hone his research even more.

Charlie is a good model for us to work with, Ferguson told Healthline.

One of the more interesting experiments the researchers have worked on is how driving on an oval track seemed to be a more difficult task for Kimball than driving on a more winding, surface street race course.

To discover what was happening, the researchers outfitted Kimball with a clear plastic box that encased his body from the waist down. The case was accompanied by some wooden blocks, cushions, and a bicycle seat.

By taking readings with the box, the researchers discovered that the blood in Kimballs lower legs was pooling more on oval courses because there are stronger g-forces.

With that knowledge, they set up a training schedule that exposed Kimball to that type of g-force to help him condition himself for it.

Ferguson said they hope to use what they learn from their experiments with Kimball to help the general population with diabetes management.

For Kimball, all of this helps him when hes on the race track.

The past two years, he has finished third and fifth in the Indy 500.

Hes hoping for an even better finish on Sunday.

If you want to keep track, Kimball will be in the car with the number 83 and the Novo Nordisk sponsor decals.

Read more: World Cup soccer stars next goal is to conquer lupus

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