New Agreement Enhances High-Parameter Panels on Cytek Cell Analysis Systems New Agreement Enhances High-Parameter Panels on Cytek Cell Analysis Systems
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Cytek® Biosciences Partners with Bio-Rad to Expand Reagent Portfolios
Collaboration will establish a platform cGMP line to support Elektrofi’s planned clinical trials of injectable biologics Collaboration will establish a platform cGMP line to support Elektrofi’s planned clinical trials of injectable biologics
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Elektrofi Announces Collaboration with Thermo Fisher Scientific to Strengthen Manufacturing Capabilities for Future Clinical Trials
VANCOUVER, British Columbia, Feb. 07, 2023 (GLOBE NEWSWIRE) -- Derm-Biome Pharmaceuticals, Inc, a Vancouver based biopharmaceutical company focused on skin health, is pleased to announce that it has been invited to present at the 2023 OBIO Investment Summit (OIS) in Toronto on Friday, February 10th at 11:51am EST. The Summit is Canada’s premier health science investment event, a forum that connects global investors with Canada’s best technology innovators. Since 2018 summit companies have raised $1.3 billion.
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Derm-Biome Pharmaceuticals to Present at the 2023 OBIO Investment Summit on February 10, 2023
The second Phase 2 clinical trial known as APEX-2 will augment the VT-X7 safety and efficacy data collected in the APEX trial. The second Phase 2 clinical trial known as APEX-2 will augment the VT-X7 safety and efficacy data collected in the APEX trial.
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Osteal Therapeutics Announces First Subject Enrollment in Second Phase 2 Clinical Trial of VT-X7 Combination Product for Treatment of Periprosthetic...
SANTA MONICA, Calif., Feb. 07, 2023 (GLOBE NEWSWIRE) -- Opiant Pharmaceuticals Inc. (NASDAQ: OPNT) announced today that the Committee on Foreign Investment in the United States (CFIUS) approved the previously announced Merger Agreement (the Agreement) for Opiant to be acquired by Indivior PLC (LSE: INDV).
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Opiant Pharmaceuticals Announces CFIUS Approval for Proposed Acquisition by Indivior PLC
YAVNE, Israel, Feb. 07, 2023 (GLOBE NEWSWIRE) -- MediWound Ltd. (NASDAQ: MDWD), a fully integrated biopharmaceutical company focused on next-generation biotherapeutic solutions for tissue repair and regeneration, today announced the closing of its previously announced registered direct offering. The gross proceeds to the Company from the offering were $27.5 million, before deducting placement agent fees and other offering expenses payable by the Company. The Company intends to use the net proceeds from the offering primarily for the acceleration of the development of EscharEx®, establishing a U.S. commercial presence, supporting business development activities, and for general corporate purposes. The Company may also use a portion of the net proceeds to in-license, invest in or acquire businesses, technologies, products or assets that it believes are complementary to its own, although it has no current plans, commitments or agreements with respect to any acquisitions or in-licenses at this time.
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MediWound Announces Closing of $27.5 Million Registered Direct Offering of Ordinary Shares
FREMONT, Calif., Feb. 07, 2023 (GLOBE NEWSWIRE) -- Cytek Biosciences, Inc. (“Cytek Biosciences” or “Cytek”) (Nasdaq: CTKB), today announced it will report financial results for the fourth quarter and full year 2022 after market close on Tuesday, February 28th, 2023. The company’s management will webcast a corresponding conference call beginning at 1:30 p.m. Pacific Time / 4:30 p.m. Eastern Time to discuss its results, business developments and outlook.
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Cytek Biosciences to Report Fourth Quarter and Full Year 2022 Financial Results on February 28, 2023
SEATTLE, Feb. 07, 2023 (GLOBE NEWSWIRE) -- Chinook Therapeutics, Inc. (Nasdaq: KDNY), a biopharmaceutical company focused on the discovery, development and commercialization of precision medicines for kidney diseases, today announced that Chinook management is scheduled to participate in a virtual fireside chat at the SVB Securities Global Biopharma Conference on Tuesday, February 14, 2023 at 11:20 am ET, as well as 1x1 meetings.
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Chinook Therapeutics to Present at SVB Securities Global Biopharma Conference
SAN CARLOS, Calif., Feb. 07, 2023 (GLOBE NEWSWIRE) -- Vaxcyte, Inc. (Nasdaq: PCVX), a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, today announced that Company management will participate in a fireside chat at the SVB Securities Global Biopharma Conference on Tuesday, February 14, 2023, at 3:00 p.m. ET / 12:00 p.m. PT.
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Vaxcyte to Present at the SVB Securities Global Biopharma Conference
BALA CYNWYD, Pa., Feb. 07, 2023 (GLOBE NEWSWIRE) -- Larimar Therapeutics, Inc. (“Larimar”) (Nasdaq: LRMR), a clinical-stage biotechnology company focused on developing treatments for complex rare diseases, today announced the appointment of Gopi Shankar, PhD, MBA, FAAPS, to the newly created position of Chief Development Officer (CDO). Dr. Shankar will report directly to Chief Executive Officer Carole Ben-Maimon, MD, and will be responsible for the strategic development of the Company’s clinical and R&D programs, including additional applications of the Company’s platform technology.
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Larimar Therapeutics Appoints Dr. Gopi Shankar as Chief Development Officer
SAN DIEGO, Feb. 07, 2023 (GLOBE NEWSWIRE) -- Viracta Therapeutics, Inc. (Nasdaq: VIRX), a precision oncology company focused on the treatment and prevention of virus-associated cancers that impact patients worldwide, today announced that Mark Rothera, its President and Chief Executive Officer, is scheduled to present at the virtual 2023 SVB Securities Global Biopharma Conference on Tuesday, February 14, 2023, at 1:00 p.m. ET.
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Viracta Therapeutics to Present at the 2023 SVB Securities Global Biopharma Conference
Proceeds to be used for debt paydown Proceeds to be used for debt paydown
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Lifecore Biomedical Announces Sale of Curation Foods’ Avocado Products Business
SOUTH SAN FRANCISCO, Calif., Feb. 07, 2023 (GLOBE NEWSWIRE) -- Tenaya Therapeutics, Inc. (NASDAQ: TNYA), a clinical-stage biotechnology company with a mission to discover, develop and deliver potentially curative therapies that address the underlying causes of heart disease, today announced that company management will participate in the SVB Securities Global Biopharma Conference and Cowen’s 43rd Annual Health Care Conference. Details of participation are as follows:
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Tenaya Therapeutics to Participate in Upcoming Investor Conferences
NEW YORK, Feb. 07, 2023 (GLOBE NEWSWIRE) -- Cellectis S.A. (“Cellectis” or the “Company”) (Euronext Growth: ALCLS - NASDAQ: CLLS), a clinical-stage biotechnology company using its pioneering gene-editing platform to develop life-saving cell and gene therapies, announced today:
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Cellectis Announces Closing of Global Offering and Exercise of Underwriters’ Option to Purchase Additional Shares
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ASKA Pharmaceutical : February 7 2023 EME and ASKA Announce Collaboration Agreement on Creating Novel PharmaLogical VHH to address an unmet medical...
Few of us know what they are or exactly how they work. But many of us have heard about the healing powers of stem cells, as well as the controversy surrounding them. Stem cells are well-debated and highly complex with promises ranging from fixing damaged knees to regenerating receding hairlines.
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But what are stem cells? And, whats all the fuss all about?
Director of the Center for Regenerative Medicine and Surgery, Amy Lightner, MD, shares the differences between stem cell types, how stem cells can be used and when to be cautious of claims that might be too good to be true.
When most of us think of stem cells, we probably recall images of Dolly the cloned sheep. While its true that Dolly was born of stem cells, her place in science history is just one of many advancements in the field.
In fact, there are many different types of stem cells, each of which has different responsibilities and abilities. What unifies them is their ability to regenerate into new cells.
Regenerative medicine is an emerging field that uses innovative treatments to help regenerate or heal cell function thats lost due to aging, disease or injury, Dr. Lightner explains. The way we achieve this is by using stem cells in large quantities, targeted to a certain area, that the body uses to promote healing.
Adult stem cells are the only type of stem cells that are currently approved for medical use in the United States by the U.S. Food and Drug Administration (FDA). The term adult stem cells is a little confusing because theyre actually found in infants, children and adults. These cells live in a variety of tissue in our bodies including bone marrow, muscles, your brain, your intestines and more.
Think of adult stem cells as a little army of cells that can regenerate themselves into new cells to maintain and repair the tissue or muscle where theyre found. The catch with adult stem cells is that they cant become different types of cells (for example, blood stem cells can only become new blood cells, not skin or brain cells).
Unlike adult stem cells, embryonic stem cells have many more possibilities. Harvested during an embryos blastocyst stage (about five or six days after an embryo has been fertilized in a lab), embryonic stem cells have the potential to become any type of cell (called pluripotent cells). For these reasons, embryonic stem cells are the type of stem cells that generate the controversy most people associate with the topic.
Stem cell therapy has been around since the 1970s, when the first adult bone marrow cells were used to treat blood disease. A bone marrow transplant allows a recipient whose bone marrow cells have been damaged by chemotherapy or disease to receive healthy bone marrow stem cells from a donor.
Those stem cells have the potential to mature within the blood system into different immune cells that recognize and fight off different types of blood cancer. And they also have the ability to heal, says Betty Hamilton, MD, Department of Hematology and Medical Oncology.
Bone marrow transplants are currently used to treat diseases including:
While you may have heard about the use of stem cell therapy for knees, back pain, arthritis, hair loss, diabetes and more, no other types of stem cell therapy beyond bone marrow transplants have yet been approved by the FDA. But thousands of clinical trials are available ranging from treatments for Crohns disease to multiple sclerosis and more. The common link between all these trials is the ability of the stem cells to reduce inflammation and repair damage to your body.
Dr. Hamilton and Dr. Lightner agree that were only just beginning to scratch the surface of stem cell therapy. In recent years, during the height of the COVID-19 pandemic, many clinical trials were underway to explore whether stem cells could be used to help treat the damaged lungs in people severely affected by the disease.
I think potential is the perfect word to describe stem cells, says Dr. Hamilton. We know they have these anti-inflammatory and regenerative properties where they can provide a significant improvement to someone dealing with a certain disease. There are so many diseases where inflammation happens, and something needs to be repaired, and so any help the immune system can get provides a lot of potential.
Scientists are also researching whether adult stem cells can turn into pluripotent stem cells, which would allow the cells to change into any cell type without involving the use of embryonic stem cells.
While the potential for stem cell therapy is great, doctors caution that were not quite there yet.
I always tell patients that ask about stem cell therapy clinics or traveling overseas for stem cell therapy treatment that if its not something that is a clinical trial with FDA oversight, then they have no real way of knowing whats being given to them, advises Dr. Lightner.
This means more harm can come than good if you dont know exactly whats being given to you. Or, in some cases, youre just spending thousands of dollars for what ends up being saline, Dr. Lightner says.
The best way to know that youre receiving sound medical treatment is to make sure the one youre considering is approved by the FDA on its Clinical Trials database.
Dr. Lightner cautions against treatments that sound too good to be true. While stem cell therapy has helped improve and save millions of lives, its best to know what exactly youre signing up for by seeking out a qualified medical provider offering an FDA-approved clinical trial.
Excerpt from:
Stem Cell Therapy Is It Right for You? Cleveland Clinic
Q: What are the types of stem cell therapy?
A: Stem cells are primitive cells that are capable of self-renewal (i.e., to divide to replenish their population); are pluripotent (i.e., able to differentiate into different mature cells); and are able to create, maintain, or repair tissues. There are several general categories of stem cells, including:
Two general stem-cell-based therapeutic strategies have been considered in MS:1
This document addresses AHSCT and MSC transplantation separately.
A: AHSCT is a multi-step procedure, which includes:
Mobilization typically is performed as an outpatient. Conditioning, PBHSC infusion, and initial recovery usually are performed during an approximately 1-month hospitalization in a specialized transplant unit.
A: A sizable number of case series, uncontrolled phase 2 clinical trials, and randomized clinical trials have demonstrated, in aggregate, potent efficacy of AHSCT in patients with active relapsing MS, including marked reduction in relapses, MRI lesion activity, and brain volume loss (after initial acceleration).1-3 In two analyses, the rate of no evidence of disease activity at 2 years was 70-90% in AHSCT case series and trials compared to 15-50% in clinical trials of MS disease modifying therapies (DMTs).4,5 A sizable proportion of patients treated with AHSCT demonstrate improvement in disability, for example, 64% at 4 years in a recent case series.6 Disease control often is durable, lasting up to 15 years or more without the need for ongoing disease modifying therapy (DMT) in many patients.7 Nonetheless, some patients require resumption of standard DMTs at some point after AHSCT, particularly with lower intensity non-myeloablative conditioning regimens.
The potent efficacy is attributed to immunoablative conditioning that depletes pathogenic immune cells; the durability of benefit is attributed more normal regulatory function and T-cell and B-cell repertoires following immune reconstitution.4
A: Early toxicity is common in patients undergoing AHSCT and potentially includes MS relapse during mobilization and conditioning, complications of leukapheresis, side effects of cytotoxic agents comprising the conditioning regimen (e.g., nausea or infertility), complications of myelosupression (e.g., infection or bleeding complications), and engraftment syndrome after re-infusion of PBHSCs (fever, rash, pulmonary edema, liver or renal impairment, and encephalopathy). Patients typically are hospitalized for approximately 1 month when undergoing conditioning and transplantation, and for initial recovery. Previous estimates of overall transplant-related mortality in MS were 2% or more. The current estimate is 0.2-0.3% for AHSCT performed after 2012.4 The improved safety is due to increased experience with the procedure, refinement of the protocol, and better selection of patients with lower risk of complications.
After recovery, adverse effects are rare and include infection (principally related to herpes zoster) and secondary autoimmune disorders. One potential advantage is that after AHSCT patients typically do not need ongoing MS DMT, with the associated cumulative risk of adverse effects.
A: The estimated cost for uncomplicated AHSCT is approximately $150,000. One potential advantage is that after recovery patients typically do not need ongoing MS DMT, with the associated cumulative cost. Nevertheless, most health insurance plans do not cover AHSCT, so obtaining coverage often is difficult.
A: Patients most likely to benefit from AHSCT are young (approximately 55 years or less), with relatively recent disease onset (approximately 10 years or less), still ambulatory, with highly active MS with recent clinical relapses or MRI lesion activity, and continued disease activity despite treatment with approved DMTs especially high-efficacy DMTs. Both the American Society for Blood and Marrow Transplantation 2 and National MS Society3 have published policy statements that AHSCT is a reasonable option in such patients, who are at high risk for disability.
A: Because of the complexity of the AHSCT procedure and the need for appropriate patient selection and follow-up, AHSCT for MS should be performed by centers with expertise and experience in transplant and that are affiliated with centers with experience and expertise in management of MS.1-3We advise patient not to undergo AHSCT in free-standing transplant clinics, especially in the absence of a detailed plan for follow-up and management of medical and neurologic issues post-transplant.
A: Because of the uncertain efficacy and safety of AHSCT compared to approved DMTs for MS, the Mellen Center is participating in the ongoing Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS) clinical trial sponsored by the National Institute of Allergy and Infectious Diseases and the Immune Tolerance Network (ClinicalTrials.gov Identifier: NCT04047628). This multicenter, randomized, rater-blinded trial compares the efficacy, safety, cost-effectiveness, and immunologic effects of AHSCT versus high-efficacy DMTs in participants with highly active, treatment-refractory, relapsing MS.
Because of unanswered questions regarding the efficacy of AHSCT in MS and substantial associated risk, our priority is to enroll patients for whom AHSCT is being considered into the BEAT-MS trial. We will consider AHSCT outside of the BEAT-MS trial for selected patients for whom AHSCT appears indicated but who are not eligible to participate in the study.
A: Typically, transplant physicians monitor and manage transplant-related adverse effects for the first 6 months following uncomplicated AHSCT (longer if there are complications). After 6 months following uncomplicated AHSCT, transplant-related adverse effects are rare. Patients need to be monitored primarily for symptoms or other findings suggesting infection or secondary autoimmune disorders. Long-term MS disease monitoring is similar to typical MS, with clinical visits and periodic MRIs.
A: Several analyses demonstrated that AHSCT has modest or no efficacy in preventing or reversing progressive disability worsening in the absence of recent relapses or MRI lesion activity. Conversely, the risk of adverse effects and transplant-related mortality are increased in progressive MS due to greater neurologic disability, older age, and increased likelihood of comorbidities. Many of the transplant-related deaths in recent series were patients with progressive MS.4 As a result, AHSCT generally is not advised for patients with non-active progressive MS and/or severe disability.
A: A recent publication reported potent efficacy of non-myeloablative AHSCT in preventing relapses, improving disability, and improving quality of life in 11 patients with aquaporin-4-positive neuromyelitis optica spectrum disorders (NMOSD).8 There now are 3 medications with regulatory approval to treat NMOSD plus several other medications used off-label. The findings from this small uncontrolled case series suggests AHSCT might be an option for patients with NMOSD who do not achieve adequate disease control from the available medication options. Rigorous formal clinical trials are needed to more definitively assess the efficacy and safety of AHSCT in NMOSD. We have not performed AHSCT for NMOSD at Cleveland Clinic.
A: Studies of various stem cell approaches to directly replace myelin-forming cells have been proposed (e.g., transplantation of oligodendrocyte progenitor cells or induced pluripotent stem cells), but none has been completed.1 To date, the most experience is with transplantation of mesenchymal stem cells (MSCs), pluripotent stromal cells present in a perivascular niche in a variety of tissues. In addition to their ability to differentiate into mesodermal lineage derivatives (e.g., bone, cartilage, connective tissue, and adipose tissue), MSCs appear to function to limit inflammatory tissue damage and promote tissue repair, including in the central nervous system, through elaboration of a large number of soluble immunomodulatory and trophic factors. These properties have led to a large number of studies investigating the potential benefit of MSC transplantation to treat a wide variety of inflammatory and tissue injury conditions.1 There also are a large number of commercial stem cell clinics offering MSC transplantation for a wide range of conditions.
A: A sizable number of preliminary trials of MSC transplantation in MS have been reported,1 including one conducted at the Mellen Center.9 These studies had different study populations, cell products, routes of administration, and study protocols, making it difficult to generalize the results. In aggregate, the studies reported good safety and tolerability, and some provided preliminary evidence of benefit. A recent study utilizing cell production procedures intended to augment production of neurotrophic factors by the MSCs and multiple intrathecal administrations, reported more prominent efficacy.10
Despite the sizable number of studies of MSC transplantation, there are a many unanswered technical questions, including the best tissue source (e.g., bone marrow, adipose tissue, or placenta/umbilical cord), whether the cells should be autologous (i.e., from the patient) or allogeneic (i.e., from someone without MS), the optimal cell culture methods to maximize yield and stimulate characteristics that increase therapeutic potency, whether the cells can be cryopreserved (frozen and stored) or need to be harvested directly from culture, dose (i.e., how many MSCs are administered), dosing schedule (i.e., for how long the therapeutic benefit lasts and how often the MSCs need to be administered), and optimal route of administration (i.e., intravenous, intrathecal, or both), among other issues. Because of these unanswered technical questions, MSC transplantation currently is an experimental treatment and should not be performed outside of rigorous formal clinical trials
A: There are a large number of commercial stem cell clinics in the U.S. and other countries offering treatments marketed as stem cells and presumed to be predominantly MSCs, on a fee-for service basis. However, because of the lack of quality control, lack of regulatory oversight, and lack of any validation of their efficacy or safety, we strongly advise patients not to pursue stem cell treatments at commercial stem cell clinics, outside of rigorous formal clinical trials. Many of these operations are potentially fraudulent.
Although MSC transplantation generally has been well-tolerated and safe in formal clinical trials, complications have been reported when administered in commercial stem cell clinics, including among other reports severe loss of vision following intravitreal injection11 and malignant spinal cord neoplasm following intrathecal injection.12
In addition, a number of concerns regarding commercial stem cell clinics have been raised: 13,14
A: Patient who undergo MSC transplantation should be monitored for symptoms or other findings indicating potential complications, including local or systemic infection, ectopic tissue formation, neoplasia, and arachnoiditis (following intrathecal administration). Long-term MS disease monitoring is similar to typical MS, with clinical visits and periodic MRIs.
Last Updated: 10 DEC 2020
Approach last updated: February 14, 2021
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Stem Cell Therapy | Mellon Center Approach | Cleveland Clinic
STEM, in full science, technology, engineering, and mathematics, field and curriculum centred on education in the disciplines of science, technology, engineering, and mathematics (STEM). The STEM acronym was introduced in 2001 by scientific administrators at the U.S. National Science Foundation (NSF). The organization previously used the acronym SMET when referring to the career fields in those disciplines or a curriculum that integrated knowledge and skills from those fields. In 2001, however, American biologist Judith Ramaley, then assistant director of education and human resources at NSF, rearranged the words to form the STEM acronym. Since then, STEM-focused curriculum has been extended to many countries beyond the United States, with programs developed in places such as Australia, China, France, South Korea, Taiwan, and the United Kingdom.
In the early 2000s in the United States, the disciplines of science, technology, engineering, and mathematics became increasingly integrated following the publication of several key reports. In particular, Rising Above the Gathering Storm (2005), a report of the U.S. National Academies of Science, Engineering, and Medicine, emphasized the links between prosperity, knowledge-intensive jobs dependent on science and technology, and continued innovation to address societal problems. U.S. students were not achieving in the STEM disciplines at the same rate as students in other countries. The report predicted dire consequences if the country could not compete in the global economy as the result of a poorly prepared workforce. Thus, attention was focused on science, mathematics, and technology research; on economic policy; and on education. Those areas were seen as being crucial to maintaining U.S. prosperity.
Findings of international studies such as TIMSS (Trends in International Mathematics and Science Study), a periodic international comparison of mathematics and science knowledge of fourth and eighth graders, and PISA (Programme for International Student Assessment), a triennial assessment of knowledge and skills of 15-year-olds, reinforced concerns in the United States. PISA 2006 results indicated that the United States had a comparatively large proportion of underperforming students and that the country ranked 21st (in a panel of 30 countries) on assessments of scientific competency and knowledge.
The international comparisons fueled discussion of U.S. education and workforce needs. A bipartisan congressional STEM Education Caucus was formed, noting:
Our knowledge-based economy is driven by constant innovation. The foundation of innovation lies in a dynamic, motivated and well-educated workforce equipped with STEM skills.
While the goal in the United States is a prepared STEM workforce, the challenge is in determining the most-strategic expenditure of funds that will result in the greatest impact on the preparation of students to have success in STEM fields. It is necessary, therefore, to determine the shortcomings of traditional programs to ensure that new STEM-focused initiatives are intentionally planned.
A number of studies were conducted to reveal the needs of school systems and guide the development of appropriately targeted solutions. Concerned that there was no standard definition of STEM, the Claude Worthington Benedum Foundation (a philanthropical organization based in southwestern Pennsylvania) commissioned a study to determine whether proposed initiatives aligned with educator needs. The study, which was administered jointly by Carnegie Mellon University (CMU) and the Intermediate Unit 1 (IU1) Center for STEM Education, noted that U.S. educators were unsure of the implications of STEM, particularly when scientific and technological literacy of all students was the goal. Educators lacked in-depth knowledge of STEM careers, and, as a consequence, they were not prepared to guide students to those fields.
The findings from several studies on educational practices encouraged U.S. state governors to seek methods to lead their states toward the goal of graduating every student from high school with essential STEM knowledge and competencies to succeed in postsecondary education and work. Six states received grants from the National Governors Association to pursue three key strategies: (1) to align state K-12 (kindergarten through 12th grade) standards, assessments, and requirements with postsecondary and workforce expectations; (2) to examine and increase each states internal capacity to improve teaching and learning, including the continued development of data systems and new models to increase the quality of the K-12 STEM teaching force; and (3) to identify best practices in STEM education and bring them to scale, including specialized schools, effective curricula, and standards for Career and Technical Education (CTE) that would prepare students for STEM-related occupations.
In southwestern Pennsylvania, researchers drew heavily on the CMU/IU1 study to frame the regions STEM needs. In addition, a definition for STEM was developed in that region that has since become widely used, largely because it clearly links education goals with workforce needs:
[STEM is] an interdisciplinary approach to learning where rigorous academic concepts are coupled with real-world lessons as students apply science, technology, engineering, and mathematics in contexts that make connections between school, community, work, and the global enterprise enabling the development of STEM literacy and with it the ability to compete in the new economy.
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STEM | Description, Development, & Facts | Britannica
STEM education is a teaching approach that combines science, technology, engineering and math. Its recent successor, STEAM, also incorporates the arts, which have the "ability to expand the limits of STEM education and application," according to Stem Education Guide (opens in new tab). STEAM is designed to encourage discussions and problem-solving among students, developing both practical skills and appreciation for collaborations, according to the Institution for Art Integration and STEAM (opens in new tab).
Rather than teach the five disciplines as separate and discrete subjects, STEAM integrates them into a cohesive learning paradigm based on real-world applications.
According to the U.S. Department of Education (opens in new tab) "In an ever-changing, increasingly complex world, it's more important than ever that our nation's youth are prepared to bring knowledge and skills to solve problems, make sense of information, and know how to gather and evaluate evidence to make decisions."
In 2009, the Obama administration announced the "Educate to Innovate (opens in new tab)" campaign to motivate and inspire students to excel in STEAM subjects. This campaign also addresses the inadequate number of teachers skilled to educate in these subjects.
The Department of Education now offers a number of STEM-based programs (opens in new tab), including research programs with a STEAM emphasis, STEAM grant selection programs and general programs that support STEAM education.
In 2020, the U.S. Department of Education awarded $141 million in new grants and $437 million to continue existing STEAM projects a breakdown of grants can be seen in their investment report (opens in new tab).
STEAM education is crucial to meet the needs of a changing world. According to an article from iD Tech (opens in new tab), millions of STEAM jobs remain unfilled in the U.S., therefore efforts to fill this skill gap are of great importance. According to a report from the U.S. Bureau of Labor Statistics (opens in new tab) there is a projected growth of STEAM-related occupations of 10.5% between 2020 and 2030 compared to 7.5% in non-STEAM-related occupations. The median wage in 2020 was also higher in STEAM occupations ($89,780) compared to non-STEAM occupations ($40,020).
Between 2014 and 2024, employment in computer occupations is projected to increase by 12.5 percent between 2014 and 2024, according to a STEAM occupation report (opens in new tab). With projected increases in STEAM-related occupations, there needs to be an equal increase in STEAM education efforts to encourage students into these fields otherwise the skill gap will continue to grow.
STEAM jobs do not all require higher education or even a college degree. Less than half of entry-level STEAM jobs require a bachelor's degree or higher, according to skills gap website Burning Glass Technologies (opens in new tab). However, a four-year degree is incredibly helpful with salary the average advertised starting salary for entry-level STEAM jobs with a bachelor's requirement was 26 percent higher than jobs in the non-STEAM fields.. For every job posting for a bachelor's degree recipient in a non-STEAM field, there were 2.5 entry-level job postings for a bachelor's degree recipient in a STEAM field.
What separates STEAM from traditional science and math education is the blended learning environment and showing students how the scientific method can be applied to everyday life. It teaches students computational thinking and focuses on the real-world applications of problem-solving. As mentioned before, STEAM education begins while students are very young:
Elementary school STEAM education focuses on the introductory level STEAM courses, as well as awareness of the STEAM fields and occupations. This initial step provides standards-based structured inquiry-based and real-world problem-based learning, connecting all four of the STEAM subjects. The goal is to pique students' interest into them wanting to pursue the courses, not because they have to. There is also an emphasis placed on bridging in-school and out-of-school STEAM learning opportunities.
Middle school At this stage, the courses become more rigorous and challenging. Student awareness of STEAM fields and occupations is still pursued, as well as the academic requirements of such fields. Student exploration of STEAM-related careers begins at this level, particularly for underrepresented populations.
High school The program of study focuses on the application of the subjects in a challenging and rigorous manner. Courses and pathways are now available in STEAM fields and occupations, as well as preparation for post-secondary education and employment. More emphasis is placed on bridging in-school and out-of-school STEAM opportunities.
Much of the STEAM curriculum is aimed toward attracting underrepresented populations. There is a significant disparity in the female to male ratio when it comes to those employed in STEAM fields, according to Stem Women (opens in new tab). Approximately 1 in 4 STEAM graduates is female.
Ethnically, people from Black backgrounds in STEAM education in the UK have poorer degree outcomes and lower rates of academic career progression compared to other ethnic groups, according to a report from The Royal Society (opens in new tab). Although the proportion of Black students in STEAM higher education has increased over the last decade, they are leaving STEAM careers at a higher rate compared to other ethnic groups.
"These reports highlight the challenges faced by Black researchers, but we also need to tackle the wider inequalities which exist across our society and prevent talented people from pursuing careers in science." President of the Royal Society, Sir Adrian Smith said.
Asian students typically have the highest level of interest in STEAM. According to the Royal Society report in 2018/19 18.7% of academic staff in STEAM were from ethnic minority groups, of these groups 13.2% were Asian compared to 1.7% who were Black.
If you want to learn more about why STEAM is so important check out this informative article from the University of San Diego (opens in new tab). Explore some handy STEAM education teaching resources courtesy of the Resilient Educator (opens in new tab). Looking for tips to help get children into STEAM? Forbes (opens in new tab) has got you covered.
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What is STEM Education? | Live Science
Today, the U.S. Department of Education (Department) will host the YOU Belong in STEM National Coordinating Conference in Washington, D.C. as a key initiative for the Biden-Harris Administration. The Raise the Bar: STEM Excellence for All Students initiative is designed to strengthen Science, Technology, Engineering and Mathematics (STEM) education nationwide. This new Biden-Harris Administration initiative will help implement and scale equitable, high-quality STEM education for all students from PreK to higher educationregardless of background to ensure their 21st century career readiness and global competitiveness.
Research shows how a sense of belonging in rich and rigorous classrooms is directly correlated to students long-term academic success. Moreover, the Departments Civil Rights Data Collection continues to demonstrate that students of color and students with disabilities are disproportionately excluded from learning opportunities in STEM, said U.S. Deputy Secretary of Education Cindy Marten. Today, we are saying unequivocally to all students and educators that they belong in STEM and that they deserve to have rigorous and relevant educational experiences that inspire and empower them to reach their full potential as productive, contributing members of our nations workforce.
In support of the initiative and its goals, the Department has:
The U.S. Department of Education invited STEM education entities to make bold commitment(s) to advance STEM education in America. We encourage you to consider the following parameters in developing your commitment:
In just three weeks, over 90 organizations and even individual educators from across the country have come forward to offer specific commitments to enhance STEM education for all. These commitments range from local grassroots efforts to initiatives that are national in scope. Those interested in joining this movement may submit a commitment here by December 31, 2022.
Albert Einstein Distinguished Educator Fellowship ProgramAmerican Federation of TeachersAmerican Institute of MathematicsAmerican University Game CenterAssociation of Science and Technology CentersBattelle/STEMxBeyond100KBlack Rocket ProductionsBreakthrough CollaborativeBrightmoor Urban Training LLCBrightSpark, Inc.Brown Toy BoxBrownSTEMCalifornia State University, Office of the ChancellorCarnegie Corporation of New YorkCenter for Energy Workforce DevelopmentCenter for Family Math at NAFSCECenter of Science and Industry (COSI)Challenger CenterChicago Public Schools - Pershing Magnet SchoolCode.orgCodeVCommunity Resources for ScienceComputer Science Teachers AssociationData Science 4 EveryoneDiscoverEEast Syracuse Minoa CSD STEM Learning EcoystemEdGE @ TERCEducate MaineEnCorps, Inc.FULL STEAM AHEAD LLC TNGGUSDHispanics for STEM IDRA & Lead of the Alamo STEM EcosystemIntel ArizonaInternational Technology and Engineering Educators AssociationIntrepid Sea, Air & Space Museum ISS National Laboratory JASON LearningKC STEM AllianceKids' Chemical Solutions Learning BladeLG Technical Services MDCPS/ TeachforAmericaMeharry School of Applied Computational SciencesMMSA/ Maine Mathematics and Science AllianceMSD of MartinsvilleNational Children's Museum
National Girls Collaborative ProjectNational Network of State Teachers of the YearNational Science Teaching AssociationNational Education AssociationNew Jersey Tutoring Corps IncNew York Hall of ScienceNI (formerly National Instruments)Niswonger Foundation / STEM.LDNorth Mason School DistrictNortheast Florida Regional STEM2 Hub, Inc. Ohio Afterschool NetworkOld Forge Elementary SchoolOut TeachOverdeck Family FoundationPartnerships in Education and Resilience (PEAR)Pennsylvania Statewide STEM EcosystemPhiladelphia Education Fund/Philadelphia STEM EcosystemPS ScienceS2TEM Centers SC/South Carolina Coalition of Mathematics and ScienceSAE FoundationScience is ElementarySHPE (Society of Hispanic Professional Engineers)Smithsonian Science Education Center, Smithsonian InstitutionSociety of Women EngineersSourcewell South Jersey STEM Innovation & PartnershipSTEM Next Opportunity FundSTEMpressarial INC.STEMSSTEMS4Girls, Inc. StudentTagpros Children InternationalTechbridge Girls Thaddeus Stevens College of TechnologyThe LEGO GroupThe New Mexico Out-of-School Time Network (NMOST)The University of Texas at Austin/ Texas Advanced Computing Center (TACC)The UTeach Institute at The University of Texas at AustinU.S. DOE Office of Elementary and Secondary EducationUnity Technologies University of HoustonUSD 457 and Kansas State Department of EducationU.S. Patent and Trademark OfficeWyoming Afterschool Alliance365 Productions Inc
BackgroundDepartment Offices that Support STEMExamples of the Department's discretionary grants that can support STEM Grant Applicant ResourcesCall for Peer ReviewersAmerica's Strategy for STEM EducationSecretary's STEM PriorityU.S. Department of Education STEM NewsletterArchived STEM NewslettersSTEM Education BriefingsUpcoming STEM BriefingsArchived STEM BriefingsResourcesOther Communications ToolsOther Federal Agency STEM WebsitesDepartment STEM Contacts
In an ever-changing, increasingly complex world, it's more important than ever that our nation's youth are prepared to bring knowledge and skills to solve problems, make sense of information, and know how to gather and evaluate evidence to make decisions. These are the kinds of skills that students develop in science, technology, engineering, and math, including computer sciencedisciplines collectively known as STEM/CS. If we want a nation where our future leaders, neighbors, and workers can understand and solve some of the complex challenges of today and tomorrow, and to meet the demands of the dynamic and evolving workforce, building students' skills, content knowledge, and literacy in STEM fields is essential. We must also make sure that, no matter where children live, they have access to quality learning environments. A child's zip code should not determine their STEM literacy and educational options.
Office of Planning, Evaluation, and Policy Development (OPEPD)Office of Career, Technical, and Adult Education (OCTAE)Office of Elementary and Secondary Education (OESE)Office of Special Education and Rehabilitative Services (OSERS)Office of Postsecondary Education (OPE)Office of Non-Public Education (ONPE)Office of Educational Technology (OET)Office of English Language Acquisition (OELA)Institute of Educational Sciences (IES)White House InitiativesFederal Student Aid (FSA)Office of Communications and Outreach (OCO)
Below are investments made in FY 2020:
You can search for open discretionary grant opportunities or reach out to the Department's STEM contacts noted below. The Forecast of Funding Opportunities lists virtually all Department discretionary grant programs for FY 2021.
The Department published in spring 2020 two new grant applicant resources. These resources were developed to (1) provide an overview of the discretionary (or competitive) grants application process and (2) offer more details intended to be used by prospective applicants, including new potential grantees. These support one of the Secretary's new administrative priorities on New Potential Grantees that was published in March 2020. They can also be found under the "Other Grant Information" on the ED's Grants webpage.
The Department is seeking peer reviewers for our Fiscal Year 2021 competitive/discretionary grant season, including in the STEM/CS areas (among others). The Federal Register notice spotlights the specific needs of the Office of Elementary and Secondary Education (OESE), the Office of Postsecondary Education (OPE), and the Office of Special Education and Rehabilitative Services (OSERS). The How to Become a Peer Reviewer slide deck provides additional information and next steps.
The STEM Education Strategic Plan, Charting a Course for Success: America's Strategy for STEM Education, published in December 2018, sets out a federal strategy for the next five years based on a vision for a future where all Americans will have lifelong access to high-quality STEM education and the United States will be the global leader in STEM literacy, innovation, and employment. It represents an urgent call to action for a nationwide collaboration with learners, families, educators, communities, and employersa "North Star" for the STEM community as it collectively charts a course for the Nation's success. The Department is an active participant in each of the interagency working groups focused on implementation of the Plan.
Learn more about what the Department and other federal agencies are doing to implement the plan in these progress reports:
Progress Reports
October 2019December 2020December 2021
Secretary Cardona finalized his six priorities for use in agency discretionary grant programs; equitable access to rigorous STEM, including computer science, experiences is noted in Priority 2. The Department also issued a revised set of common instructions for grant applicants.
In February 2020, the Department created the U.S. Department of Education STEM Newsletter. Please go to our newsletter subscription page to sign-up.
January 2023October/November 2022September 2022August 2022July 2022May 2022April 2022March 2022February 2022January 2022December 2021November 2021October 2021October 2021 AddendumSeptember 2021August 2021July 2021June 2021 May 2021 April 2021 January 2021 December 2020 November 2020 October 2020September 2020August 2020July 2020June 2020May 2020April 2020March 2020February 2020
The STEM Education Briefings are live-streamed, close-captioned and archived for your convenience.
There are no upcoming STEM briefings at this time.
November 15, 2022 Public Health and STEM with CDC (presentation slides [MS PowerPoint, 40MB])September 16, 2022 The Pathway to Convergence (presentation slides [MS PowerPoint, 77MB])July 19, 2022 Girls in STEM(21stCCLC Summer Symposium)April 26, 2022 Learning with NASA is Out of this WorldMarch 25, 2022 Science: Call to Action (presentation slides [MS PowerPoint, 22MB])February 24, 2022 Rural STEM Education (presentation slides [MS PowerPoint, 125MB])January 19, 2022 - Think Globally, Teach Locally (presentation slides [PDF, 10MB])December 9, 2021 Environmental LiteracyNovember 30, 2021 Energizing STEM (presentation slides [PDF, 6.7MB])October 15, 2021 Data Literacy (presentation slides [PDF, 12.6MB])July 28, 2021 Advanced Manufacturing: Industry of the Future (presentation slides [PDF, 11.3MB])May 4, 2021 Summertime STEM (presentation slides [PDF, 18.3MB])March 25, 2021 Differing Abilities in STEM, featuring Dr. Temple Grandin (presentation slides [PDF, 13.7MB])February 2021 Inspiring STEM Interest (presentation slides [PDF, 3.7MB])December 2020 New Frontiers in K-12 Computer Science (presentation slides [PDF, 12.7MB])November 2020 Federal STEM Strategic Plan: 2 Years Later (presentation slides [PDF, 15.49MB]).October 2020 Invention Education (presentation slides [PDF, 13.13MB])September 2020 STEM Teacher Preparation (presentation slides [PDF, 3.5MB])August 2020 Cybersecurity Education (presentation slides [PDF, 10.5MB])July 2020 Early Math (presentation slides [PDF, 2.37MB])June 2020 Distance LearningFebruary 2020 STEM After SchoolJanuary 2020 STEAM: Arts Supporting STEMDecember 2019 Family Engagement in STEMNovember 2019 The STEM Opportunity IndexOctober 2019 Early Engineering Education and State EffortsSeptember 2019 Recruiting and Retaining 100K STEM Teachers in 10 YearsJuly 2019 What Do We Know about Computer Science Education?
Assisting Students Struggling with Mathematics: Intervention in the Elementary GradesDesigning and Delivering Career Pathways at Community CollegesLearning in a Pandemic WebinarFall 2020 Back-to-School Success StoriesCOVID-19 Information and Resources for Schools and School PersonnelESEA, IDEA, and Perkins ResourcesCollege Scorecard updated again on 1/15/21Exploring Career Options FSAWork-Based LearningStackable Credentials that lead to careersCross-agency teacher resourcesIES data and statistics, research and evaluation, and tools for educatorsOut of School STEM InitiativesThe ED Games Expo "Goes Virtual" to Support Distance LearningSTEM Data Story A Leak in the STEM Pipeline: Taking Algebra EarlyCTE Data Story Bridging the Skills Gap: Career and Technical Education in High SchoolSTEM Spotlights Parent and Family Digital Learning GuideEarly Learning: STEM Math VideoKeep Calm and Connect All Student OET Blog SeriesK-12 Practitioners' CircleSTEM Innovation for Inclusion in Early Education (STEMI2E2) Center and OSEP's Early Learning NewsletterA Transition Guide to Postsecondary Education and Employment for Students and Youth with DisabilitiesCTE Research CenterCivil Rights Data CollectionDepartment's Data Strategy
Homeroom BlogPress ReleasesTwitterNewsletter Subscriptions
The following are federal agencies that the Department collaborates with to support the aims of the STEM Education Strategic Plan (see above section for more details) and support the Department's stakeholders.
More here:
Science, Technology, Engineering, and Math, including Computer Science - ed