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Mets Group started up its bioproduct mill – European Biotechnology

August 17th, 2017 3:44 am

Finnish Mets Group has started its mill for bio-based products. The 1.2bn investments production capacity is 1.3 million tonnes of softwood pulp a year.

According to the Finnish company, pulp deliveries from the new mill to customers will begin in early September 2017. Mets said that its old pulp mill in nekoski has been shut down and is currently be dismantled.

The new mill will achieve its nominal capacity approximately a year after start-up. Mets Group will be the worlds biggest producer of softwood pulp, said Ilkka Hml, CEO of Mets Fibre. The mill will produce 1.3 million tonnes of pulp per year, along with other bio-based products such as tall oil and turpentine. New bioproducts include product gas from bark, sulphuric acid from the mills odorous gases, and biogas and biofuel pellets from sludge.

The mill will be a platform for production of new bio-based products among them lignin products, textile fibres, and biocomposites. The next-generation bioproduct mill will not use any fossil fuels at all, since it will generate all of the energy that it needs from side streams. In terms of its energy efficiency, the mill is among the world's best within its industry. Its degree of self-sufficiency in electricity is 240 per cent.

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Prana Biotechnology Ltd (PBT.AX) A Look Inside the Technicals – Morgan Research

August 17th, 2017 3:44 am

Needle moving action has been spotted in Prana Biotechnology Ltd (PBT.AX) as shares are moving today onvolatility0.00% or $0.00 from the open.TheASX listed companysaw a recent bid of $0.055 and155324shares have traded hands in the session.

Some investment professionals believe that a great way to find, study, and invest in equities without getting completely overwhelmed, is to have a systematic and research driven approach. Of course, the same approach may not work for everybody. One investor may find one way that works for them, and another investor might find something completely different when it comes to portfolio picking. Trading and investing can carry a major emotional component. Even after careful research, being able to pull the trigger on a trade may still involve squashing the fear that comes with the thought of being wrong. Finding continued success in the stock market may entail keeping the portfolio balanced, but also finding the courage to get in when necessary, or get out when needed. Developing this confidence may take a lot of practice and determination.

Now letstake a look at how the fundamentals are stacking up for Prana Biotechnology Ltd (PBT.AX). Fundamental analysis takes into consideration market, industry and stock conditions to help determine if the shares are correctly valued. Prana Biotechnology Ltd currently has a yearly EPS of -0.02. This number is derived from the total net income divided by shares outstanding. In other words, EPS reveals how profitable a company is on a share owner basis.

Another key indicator that can help investors determine if a stock might be a quality investment is the Return on Equity or ROE. Prana Biotechnology Ltd (PBT.AX) currently has Return on Equity of -26.73. ROE is a ratio that measures profits generated from the investments received from shareholders.

In other words, the ratio reveals how effective the firm is at turning shareholder investment into company profits. A company with high ROE typically reflects well on management and how well a company is run at a high level. A firm with a lower ROE might encourage potential investors to dig further to see why profits arent being generated from shareholder money.

Another ratio we can look at is the Return on Invested Capital or more commonly referred to as ROIC. Prana Biotechnology Ltd (PBT.AX) has a current ROIC of -26.73. ROIC is calculated by dividing Net Income Dividends by Total Capital Invested.

Similar to ROE, ROIC measures how effectively company management is using invested capital to generate company income. A high ROIC number typically reflects positively on company management while a low number typically reflects the opposite.

Turning to Return on Assets or ROA, Prana Biotechnology Ltd (PBT.AX) has a current ROA of -24.71. This is a profitability ratio that measures net income generated from total company assets during a given period. This ratio reveals how quick a company can turn its assets into profits. In other words, the ratio provides insight into the profitability of a firms assets. The ratio is calculated by dividing total net income by the average total assets.

A higher ROA compared to peers in the same industry, would suggest that company management is able to effectively generate profits from their assets. Similar to the other ratios, a lower number might raise red flags about managements ability when compared to other companies in a similar sector.

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New method to 3D print living tissues developed – Livemint

August 17th, 2017 3:44 am

Scientists at the University of Oxford in the UK devised a way to produce tissues in self-contained cells that support the structures to keep their shape. Photo: iStock

London: Oxford scientists have developed a new method to 3D-print laboratory-grown cells to form living structures, an advance that may help repair damaged body parts. The approach could revolutionise regenerative medicine, enabling the production of complex tissues and cartilage that would potentially support, repair or augment diseased and damaged areas of the body, researchers said.

Scientists at the University of Oxford in the UK devised a way to produce tissues in self-contained cells that support the structures to keep their shape. The cells were contained within protective nanolitre droplets wrapped in a lipid coating that could be assembled, layer-by-layer, into living structures. Producing printed tissues in this way improves the survival rate of the individual cells, and allowed the team to improve on current techniques by building each tissue one drop at a time to a more favourable resolution.

To be useful, artificial tissues need to be able to mimic the behaviours and functions of the human body, researchers said. The method enables the fabrication of patterned cellular constructs, which, once fully grown, mimic or potentially enhance natural tissues.

We were aiming to fabricate three-dimensional living tissues that could display the basic behaviours and physiology found in natural organisms, said Alexander Graham, scientist at OxSyBio (Oxford Synthetic Biology).

To date, there are limited examples of printed tissues, which have the complex cellular architecture of native tissues. Hence, we focused on designing a high-resolution cell printing platform, from relatively inexpensive components, that could be used to reproducibly produce artificial tissues with appropriate complexity from a range of cells including stem cells, said Graham. The research was published in the journal Scientific Reports.

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Novo Nordisk’s diabetes drug succeeds in key trial – WHTC

August 17th, 2017 3:43 am

Wednesday, August 16, 2017 5:33 p.m. EDT

(Reuters) - Novo Nordisk A/S said on Wednesday its diabetes drug met the main goal of reducing glucose levels in patients in a key late-stage trial, setting the stage for it to become the new standard therapy for type 2 diabetes.

The 40-week trial tested two dosages of Novo's once-weekly drug, semaglutide, in addition to initial standard-of-care therapy metformin, against Eli Lilly and Co's dulaglutide plus metformin.

Novo Nordisk said its drug was statistically significant in reducing glucose levels and lowering body weight in about 1,200 patients suffering from type 2 diabetes, when compared with dulaglutide.

Type 2 diabetes, closely linked to obesity, accounts for more than 90 percent of all diabetes cases.

The trial results could have been offset by an increase in cases of diabetic retinopathy, which leads to vision loss, Guggenheim analyst Tony Butler noted.

However, Novo Nordisk said on Wednesday the number of patients reporting an adverse event of diabetic retinopathy was low and comparable in both the arms.

"We are excited about the potential of semaglutide to set a new standard for treatment of type 2 diabetes," the company said.

Semaglutide and dulaglutide belong to the GLP-1 category of drugs which imitate an intestinal hormone that stimulates the production and absorption of insulin.

With both the drugs offering significant benefits, pricing will continue to be the most important factor in the diabetes space, Jefferies analyst Heffrey Holford said in a client note.

Lilly's dulaglutide, which is sold under the brand name Trulicity, is one of the main growth drivers of the drugmaker's success.

Dulaglutide generated sales of $480 million in the second quarter, accounting for about half of the company's new product sales.

"While we project that Lilly will retain its leadership position in the once-weekly segment, Novo has made headway with its oral formulation that could potentially shift the market dynamics in its favor over the longer term," Barclays analysts said.

(Reporting by Divya Grover in Bengaluru; Editing by Shounak Dasgupta)

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Girl with diabetes banned from water slide because of insulin pump, mom claims – Fox News

August 17th, 2017 3:43 am

A 12-year-old girl with Type 1 Diabetes says she was not permitted to ride the water slides at a public water park in Kettering because of the insulin pump attached to her body.

Mom Beth McBride claims the city of Kettering broke the law by violating the Americans With Disabilities Act, while city and waterpark officials are not yet commenting on the issue.

"She was in tears and upset, as she has every right to be, I mean she was discriminated against basically," McBride told Fox 45.

She snapped a picture of daughter Alexis looking defeated right after she was denied a ride on one of the waterslides at the "adventure reef waterpark."

12-year-old Alexis said a lifeguard told her the reason she could not ride was the insulin pump attached to her right hip.

"It was that one slide and that one lifeguard, that when I walked up there she pointed at my insulin pump and said you cannot go on the slide with that on," Alexis said.

Alexis said the pump makes her insecure and this was the first occasion that she had worn a two-piece bathing suit and exposed it in public.

"It's completely true bliss, the insulin is actually in a chamber here," McBride said showing Fox 45 the small external pump, "it's made to be worn in water parks, it's made to be worn in the ocean, in showers and bathtubs, she's allowed to wear it."

McBride related it to having Alexis' pancreas functioning outside her body. She said if it is removed, Alexis could die.

McBride also said the lifeguard did not explain the reason behind asking Alexis to remove the pump.

"I said do you realize that's an ADA violation, she has a medical handicap, the insulin pump cannot be removed," McBride said.

According to title three of the Americans With Disabilities Act, "providers of public accommodations must provide you with services that are not any different from those they provide people without a disability. They must not screen out or exclude you because of your disability."

McBride took her concern about the violation to park managers who she says took an incident report Monday night.

"She should be able to wear a medical devices with pride," McBride said.

"I'm not as different as everybody else is and I shouldn't be singled out from everybody else that's having fun," said Alexis.

McBride said she wanted to raise awareness for Type 1 Diabetes related issues and wants to make sure this does not happen to anyone else at any catering facilities.

This article originally appeared on Fox 45 Now

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Health District is offering a free Diabetes Self-Management Workshop – KEPR 19

August 17th, 2017 3:43 am

Health District offering a free Diabetes Self-Management Workshop

KENNEWICK, Wash. Benton-Franklin Health District health professionals said diabetes effects a significant number of people in Benton and Franklin counties.

Now the health district is offering a free workshop to help reduce this health threat.

"One in every two people has pre-diabetes, one in every two people," Registered Dietitian and Nutritionist Laili Abd Latif stressed.

Latif said a staggering number of people in Benton and Franklin counties are suffering from diabetes or are at high risk, but dont know.

"Because it's almost like a silent disease, you dont really know the disease until you get tested," she said.

Many of the at-risk groups include the Hispanic, Asian, and African-American populations.

If you have pre-diabetes, she said with intervention like changing your diet, adding physical activity, and developing a healthier lifestyle, pre-diabetes can be reversed.

Abd Latif and other health advocates are urging people who are over the age of 40, overweight, have a baby larger than nine pounds, or have a history of diabetes to get screened.

"If you know, you can work towards improving yourself, she said. But if you don't know, you'll be walking around for 10 years with diabetes, and then the complication of diabetes already sets in."

She said by not managing your diabetes, it will drive up medical costs and increase medical complications later in life.

"When you have diabetes, you don't just have diabetes, you also have high blood pressure, you have high tri-glyceride, and high cholesterol," Abd Latif said.

Thats why the Benton-Franklin Health District is offering a free Diabetes Self-Management Workshop.

The Diabetes Self-Management class will be offered on Thursdays from 4:00 to 6:30 p.m., from August 17 to September 21. The workshop will be held at Benton-Franklin Health District, 7102 W Okanogan Place in Kennewick.

The evidence-based program from Stanford School of Medicine empowers people with diabetes to maintain and improve their health.

It is led by people who have diabetes themselves, so they understand what the diabetes community is going through.

"So its really more of a support group," said Liza Gonzalez, community health worker and program coordinator for the workshop.

Gonzalez said the six-week class will teach you ways to deal with fatigue and pain, improve nutrition and exercise choices, communicate better with healthcare providers and family members and develop weekly action plans.

"If we can learn to be healthy and if we can take action in how to be healthy, this is a starting point for you," she said.

Unfortunately, Gonzalez said many times people don't take advantage of these free health education programs.

"We're all busy, she admitted. But where are we going to be if we don't take care of ourselves first?"

Gonzalez and Abd Latif believe that together they can transform the lives of those in living with diabetes in our community.

The educational class is open to all people with diabetes, those with family members with diabetes, or those who care for diabetes. To register for the class or for more information about the free workshops, call Lisa Gonzalez at 509-460-4216.

The Benton Franklin Health District and the Tri-Cities Diabetes Coalition is also hosting a Diabetes Awareness Fair Oct. 7 from 10:00 a.m. 1:00 p.m. at Pasco High School. Admission is free and there will be door prizes.

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Study calls for action to help adolescents with diabetes transition to adult care – Medical Xpress

August 17th, 2017 3:43 am

Dr. Meranda Nakhla is the lead author of a study, which was published in BMJ Open Diabetes Research & Care, that calls for action to help adolescents with diabetes transition to adult care. Credit: McGill University Health Centre

Adolescence can be a turbulent period of life, with struggles to establish autonomy, identity issues and risk-taking behaviours. For young adults with a chronic illness such as type 1 diabetes, this transition phase also brings about other challenges as they assume an increased responsibility for their overall health. A new study from the Research Institute of the McGill University Health Centre (RI-MUHC) sheds light on gaps in transition care practice in Quebec, pointing out a lack of standardized policies across pediatric diabetes centres. These findings, which were published in the open-access journal BMJ Open Diabetes Research & Care, highlight a need for the evaluation and development of targeted interventions at multiple levels to improve the transition process.

"The transition from pediatric to adult care is a huge and complex process that is not unique to type 1 diabetes. It also occurs with other childhood chronic diseases such as cystic fibrosis or in kidney transplant recipients,'' says the study's senior author Dr. Meranda Nakhla, a pediatric endocrinologist at the Montreal Children's Hospital of the MUHC and an assistant professor of Pediatrics at McGill University. "Previous studies have shown that transition is a vulnerable period when adolescents tend to fall out of medical care, meaning that once they leave pediatric care to be transferred to adult care they do not have regular follow up for their chronic illness.''

According to Dr. Jan Hux, chief science officer at Diabetes Canada, which funded the study, adolescence is a time when young people may start to rebel against the daily rigours of living with this 24/7 disease and take risks that may affect their health in later years. "As noted in Diabetes Canada's Clinical Practice Guidelines, there needs to be a well-prepared and supported move to adult care that includes a transition coordinator, patient reminders, and education," she says. "Having strong transitional care and support as they move to this new stage of life can have a great impact on their lives. As this study points out, more work needs to be done to ensure these needs are being effectively met."

Currently, one in four Canadians lives with diabetes and Quebec has one of the highest incidence rates of the disease among children in the world (32 per 100,000 per year). Type 1 diabetesan illness in which the body produces little or no insulin and requires daily insulin injections for lifeis one of the most common chronic diseases in childhood.

In this study, researchers focused on the perspective of pediatric care providers from academic, non-academic and rural health facilities in Quebec. They conducted in-depth interviews with diabetes nurses, educators, pediatricians and pediatric endocrinologists from 12 centres across the province between June and November 2015. The care providers were asked for their perspective, experiences and the barriers that they see are in the way of achieving a successful transition from pediatric to adult care.

"We found there were huge gaps in transition care practices such as the lack of a standardized transition care policy, limited communication between the pediatric and adult healthcare settings and an absence of structure for pediatric care providers to implement transition care practices,'' explains Dr. Nakhla, who is also a scientist from the Centre for Outcomes Research and Evaluation at the RI-MUHC. "Good intentions are there and everyone recognizes that this transition is important but more structure and guidance are needed for pediatric providers to implement it better within their practices.''

The study reported that pediatric care providers recognized the importance of transition care but only 25 per cent reported having any formal and structured transition preparation and planning in their diabetes centres. Some of the barriers that pediatric providers perceived as important were the lack of adult care providers and a multidisciplinary team in the adult care setting, less flexibility in scheduling adult healthcare appointments, patients' struggles with multiple new responsibilities such as starting secondary education, employment or moving away from home. Another barrier that was addressed was the pediatric providers' lack of time in planning for transition and lack of resources, including human resources, in implementing transition care services.

"As healthcare practitioners, we need to start the transition process early and not in the year before adolescents get transferred to adult care. We also need to make more efforts to engage families and guide parents to progressively give their teenagers more responsibility without taking unnecessary risks," says Dr. Nakhla

Researchers are currently using a health administrative database in Quebec to look at what happens to these young adults in terms of hospitalization, emergency department visits and health outcomes when they transfer to adult care.

Explore further: Better info needed in transfer from peds to adult care for T1DM

More information: Meranda Nakhla et al, Improving the transition from pediatric to adult diabetes care: the pediatric care provider's perspective in Quebec, Canada, BMJ Open Diabetes Research & Care (2017). DOI: 10.1136/bmjdrc-2017-000390

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TAT holds global medical tourism event: "Amazing Thailand Health and Wellness Tourism Showcase 2017," focusing … – Markets Insider

August 17th, 2017 3:42 am

BANGKOK, Aug. 17, 2017 /PRNewswire/ -- Mr. NoppadonPakprot, Deputy Governorfor Tourism Products and Business,Tourism Authority of Thailand (TAT) presided over the Amazing Thailand Health and Wellness Tourism Showcase 2017 yesterday, which unveiled the latest "Functional & Regenerative Medicine" innovation in Thailand.

Mr. NoppadonPakprot, Deputy Governorfor Tourism Products and Business at TAT said, "Thailand has long been recognized as a world destination for medical tourism. According to a report by VISA and Oxford Economics, Thailand has once more been confirmed as one of Asia's top medical tourism destinations. Thailand now has 58 JCI-accredited hospitals, more than any other Southeast Asian country."

The Amazing Thailand Health and Wellness Tourism Showcase 2017, under the concept "Thailand: a Paradise for Longevity", showcased Thailand as a destination for longevity products and services.

Thailand has adopted the latest innovative medicine of the century: "Functional & Regenerative Medicine," the most popular health trend in the world. In fact, Thailand is the first and only country in Asia that has specialized Functional & Regenerative Medicine hospitals, namely Better Being Hospital and MALI hospital

Moreover, Thailand has become an anti-aging center in Asia with the largest number of American Academy of Anti-Aging Medicine-certified medical professionals in Asia with 500 doctors.

"Recently, the government implemented new medical tourism policies extending the visitor stay period to 90 days for members of CLMV countries andTaiwan in order to accommodate medical tourists traveling to Thailand. In addition, the long-stay visa has also been extended to 10 years for 14 countries as follow: Japan, Australia, Denmark, Finland, France, Germany, Italy, Netherlands, Norway, Sweden, Switzerland, UK, Canada and the U.S. These two recent policies should further enhance the positioning of Thailand to be a world-class medical tourism hub recognized the world over."

Mr. Noppadonnoted: "This is the 4th such event that TAT has organized, and this year we proudly present the top 44 Health and Wellness providers in Thailand. This event will display the potential of Thailand along with its plethora of health and wellness products to international awareness. It will also provide a marketing platform for Thai health and wellness providers to discuss prospective business deals with medical tourism facilitators and travel agencies from across the globe."

The one-day event highlighted why Thailand is a "Paradise for Longevity", along with holding an informative presentation on the concept of "Functional & Regenerative Medicine. In the afternoon, buyers had the chance to discuss business deals with the top 44 health and wellness providers in Thailand, including: General Hospital, Plastic Surgery Hospital, Regenerative Functional Medicine Hospital, Anti-Aging Clinic, Cosmetic & Aesthetic Clinic, Dental Clinic, Cell Therapy Clinic, and Lab Check Up, all of whom were ready to discuss prospective business deals with international buyers.

Mr. NoppadonPakprot concluded as follows: "We hope that this event will further strengthen the awareness of Thailand as the premier destination for health and wellness tourism, and that the trade event would help generate more than 500 million Baht to the Thai economy."

Ms. Jittima Udayachalerm, Director, Royal Orchid Plus Business Unit said, "Royal Orchid Plus is delighted to be part of this global medical tourism event at this time. We've created exciting marketing activities to support this project. "We've organized a special event, inviting Royal Orchid Plus Platinum and Gold members to come and get health check-ups for free, and also given them the chance to meet and buy special packages from the hospitals and clinics at the event. Additionally, we will promote an exclusive health and wellness deal to Royal Orchid Plus members through our online channels, including email, social media, and our website."

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Biobanking Market by Product and Service(Equipment, Consumables, Services, Software), Sample Type (Blood … – Markets Insider

August 17th, 2017 3:42 am

NEW YORK, Aug. 16, 2017 /PRNewswire/ -- Factors driving the growth of this market include the increasing number of genomics research activities for studying diseases; advances in biobanking and the growing trend of conserving cord blood stem cells of newborns; government & private funding to support regenerative medicine research, and the growing need for cost-effective drug discovery and development. On the other hand, the growth of this market is hindered to some extent due to the high cost of automation and issues related to biospecimen sample procurement.

Read the full report: http://www.reportlinker.com/p05064741/Biobanking-Market-by-Product-and-Service-Equipment-Consumables-Services-Software-Sample-Type-Blood-Products-Human-Tissues-Cell-Lines-Nucleic-Acids-Application-Regenerative-Medicine-Life-Science-Clinical-Research-Global-Forecast-to.html

"Automated storage is expected to register the highest CAGR during the forecast period" The biobanking market is classified by storage type into manual and automated storage. The automated storage type segment is expected to grow at a higher rate during the forecast period. This is attributed to launch of new and advanced automated storage equipment and increasing demand for the quality storage of samples.

"Regenerative medicine to dominate the market during the forecast period"The biobanking market is segmented based on applications regenerative medicine, life science research, and clinical research. In 2017, the regenerative medicine segment is expected to command the largest share and is also estimated to grow at the fastest rate as compared to other segments. This can be attributed to increasing research activities in the field of regenerative medicine and rising demand for well-annotated and quality biosamples for research.

"Asia-Pacific is estimated to grow at the highest CAGR during the forecast period" Geographically, the biobanking market is dominated by North America, followed by Europe. The Asia-Pacific region is estimated to grow at the fastest rate which can be attributed to the large population in China and India, increasing research in regenerative medicine, and improving life sciences research infrastructure in the region.

The primary interviews conducted for this report can be categorized as follows:

The key players in the biobanking market include Thermo Fisher Scientific Inc. (U.S.), Tecan Group Ltd. (Switzerland), Qiagen N.V. (Germany), Hamilton Company (U.S.), Brooks Automation (U.S.), TTP Labtech Ltd (U.K.), VWR Corporation (U.S.), Promega Corporation (U.S.), Worthington Industries [(Taylor Wharton, U.S.)], Chart Industries (U.S.), Becton, Dickinson and Company (U.S.), Merck KGaA (Germany), Micronic (Netherlands), LVL Technologies GmbH & Co. KG (Germany), Panasonic Healthcare Holdings Co. Ltd (Japan), Greiner Bio One [Greiner Holding AG, Austria)], Biokryo GmbH (Germany), Biobank AS (Norway), Biorep Technologies Inc. (U.S.), Cell & Co Bioservices (France), RUCDR infinite biologics (U.S.), Modul-Bio (France), CSols Ltd (U.K.), Ziath (U.K.), and LabVantage Solutions Inc. (U.S.).

Study Coverage:The report analyses the biobanking market by product and service, sample type, storage type, application and regions. Apart from comprehensive geographic & product analysis and market sizing, the report also provides a competitive landscape that covers the growth strategies adopted by industry players over the last three years. In addition, the company profiles comprise the product portfolios, developments, and strategies adopted by prominent market players to maintain and increase their shares in the market.

Market research data, current market size, and forecast of the future trends will help key market players and new entrants to make the necessary decisions regarding product offerings, geographic focus, change in strategic approach, and levels of output in order to remain successful in the type, products, applications, end users, and regions.

Key benefits of buying the Report:This report will enable both established firms as well as new entrants/smaller firms to gauge the pulse of the market, which in turn will help these firms garner greater market shares. Firms purchasing the report can use any one or a combination of the below-mentioned five strategies for strengthening their market shares.

The report provides insights on the following pointers:

Read the full report: http://www.reportlinker.com/p05064741/Biobanking-Market-by-Product-and-Service-Equipment-Consumables-Services-Software-Sample-Type-Blood-Products-Human-Tissues-Cell-Lines-Nucleic-Acids-Application-Regenerative-Medicine-Life-Science-Clinical-Research-Global-Forecast-to.html

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Researchers map brain tumour cells’ adaptation to oxygen deprivation – Medical Xpress

August 17th, 2017 3:42 am

The most aggressive variant of brain tumour glioblastoma has an average survival rate of 15 months. There is therefore an urgent need for new treatment strategies for this group of patients. A research team from Lund University in Sweden has now identified new factors which may affect the tumour cells' ability to resist treatment. The study has been published in Cell Reports.

The most common form of brain tumour is called glioma. Patients with the most aggressive variant glioblastoma are treated intensively with surgery, radiation and chemotherapy. Despite this, the tumour inevitably returns as a treatment-resistant lesion.

"There are strong indications that only a small proportion of the cells in the tumour those known as cancer stem cells are resistant to treatment and therefore affect the recurrence of the tumour. In our studies, partly on mice and partly on human glioma cells, we mapped the signal pathways that apparently differ from treatment-resistant to treatment-sensitive glioma cells. Part of the explanation for this resides in the cells' response to oxygen deprivation," explains Alexander Pietras, who headed the study at Lund University.

Oxygen deprivation often occurs in tumour cells, partly because they grow faster than new blood vessels can be formed, and partly because the blood vessels in the tumour are often of inferior quality and therefore unable to supply oxygen to the same extent. Researchers already knew that oxygen-deprived tumours are often more aggressive. Now, the research team in Lund has discovered that a specific marker (CD44) present on the surface of the cancer stem cells interacts with a protein (HIF-2a) which is central to the adaptation to oxygen deprivation.

"When a cell becomes deprived of oxygen, HIF is stabilised, leading to a number of adaptations which save energy and contribute to the formation of new blood vessels, among other things. In cancer stem cells, this signal pathway seems to be active even when the cells are not being deprived of oxygen. Our findings indicate that the interaction with CD44 which is specific to cancer stem cells is crucial to this oxygen-independent stabilisation of HIF."

In normal cases, these signal pathways are tightly regulated, but in the cancer stem cells in cases of glioblastoma, these functions appear to be partly disabled. The findings explain how cancer stem cells can exploit HIF despite often being located in the parts of the brain tumour with the best oxygen supply, right next to blood vessels. The cancer stem cells' response to oxygen deprivation is thus regulated differently, resulting in more aggressive cancer cells, which do not respond to treatment. These cancer stem cells could be those responsible for recurrence of the disease, according to the researchers behind the study.

"We want to use this new knowledge to affect the resistant cells in a more treatment-sensitive direction, by impairing the signal pathway between CD44 and HIF-2a a potentially useful strategy in a number of other tumour forms as well, in which HIF and CD44 are thought to be significant, such as kidney cancer," concludes Alexander Pietras.

Explore further: Brain cancer study reveals therapy clues

More information: Elinn Johansson et al. CD44 Interacts with HIF-2 to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells, Cell Reports (2017). DOI: 10.1016/j.celrep.2017.07.049

Journal reference: Cell Reports

Provided by: Lund University

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Amanda Grappone Osmer breaks down car sales stereotypes with focus on kindness, integrity – The Keene Sentinel

August 17th, 2017 3:41 am

In 2014, during a speech in Manchester, Amanda Grappone Osmer made a startling admission.

I know why you hate me, she began, when it came her time to speak at TEDx Amoskeag Millyard. You all have memories of someone like me that takes you back to a time and place that you wish you didnt have to think about.

Your palms start to sweat. Your stomach is in a knot. Like me, your heart races. You just have an overall feeling of dread.

Mentally, you start to make a tally when you see me coming of all the ways you might get ripped off.

She describes further this experience with her at its center.

When you see me, you load up for bear. Because you know you need to, just to get through our conversation, she says.

You hate me because I am a car salesman. A fourth-generation car salesman.

And with a deep breath, she adds, I understand.

Osmers speech spoke to a stereotypical experience someone might have purchasing a car, an experience that she likened to being under the ether and one that her companys philosophy seeks to counter. Her personal mission and that of Grappone Automotive Group in Bow, for which she is CEO, moves well past the showroom to all aspects of the business, employee relationships and the manner in which she leads an engaged community life.

The business mission: Dedication to building lifelong relationships with our team members, guests and community by serving with integrity, kindness and respect.

And ingrained among her personal objectives is being a little bit better than the day before.

Osmer, the keynote speaker for The Keene Sentinels Extraordinary Women Awards on Aug. 24, graduated from the University of New Hampshire with a degree in humanities. In her teens, she worked at her familys dealership, which was started by her great-grandparents in Concord in 1924 as a Gulf service station. It is now five dealerships. But, despite her early work at the dealership, Osmer didnt envision a future for herself in the cars.

In 2001, after school and marriage, she moved to the West Coast, to the North Bay region of San Francisco. Her marriage ended after a short time, leaving her uncertain what to do next. She applied for all sorts of jobs with no luck, she says. Needing something and knowing something about cars, she found herself selling for Lexus of Marin.

I had never sold anything in my life, she says from her second-floor office at Grappones Toyota franchise, not far from the end of Interstate 89. Her notion of sales, she says, was all wrong, and she learned, You have to be nice to people and honest, and you will earn their business.

Three years later, she was back at her family dealership, in charge of fixed operations service, paint and collision. She described this as the hardest job of my life.

It was difficult to find technicians who met company standards, and there were myriad other workforce challenges, not the least of which is that few women run collision and service centers.

I knew nothing about that world, she recalls. It was constant stress.

But it was in this role that she discovered new ways of doing things that would change her and the company she would come to run. She found a mentor in Jeffrey Liker, the author of The Toyota Way, a best-seller at more than 650,000 copies and translated into 27 languages.

Liker, with whom Osmer corresponds, is professor of industrial and operations engineering at the University of Michigan and has written extensively about how Toyotas manufacturing processes employed principles to reduce waste, boost efficiency and create collaborative workforces to solve problems. He has also profiled other companies using these strategies and measurements, first pioneered by W. Edwards Deming in post-World War II Japan.

I fell in love with lean manufacturing, says Osmer, referring to the umbrella term under which these principles exist.

She opens Likers book frequently; her copy is dog-eared, heavily highlighted and fingerprinted and never far from reach. There are, in the lean world, seven categories of waste transport, inventory, motion, waiting, overproduction, over-processing and defects.

Osmer considers it one of her lifes highlights being invited to speak at the headquarters of Dupont in Delaware at a gathering of collision center specialists a conference at which Liker was speaking, too.

Shes asked if Grappone is an efficient operation.

Its a goal, she says candidly, referring to a never-ending focus on continuous improvement.

From the service operation, Osmer was promoted to COO and director of sales. The sales process was going through a similar evolution, she says.

We had peeled away from the current (traditional) way of doing things, she says, referring to the industry standard of commission-based selling. We had to figure out what is our way I really started to notice that we didnt have anyone recognizing the human experience.

The company hired a director of corporate potential a key decision and embarked on strategic planning that led to an unusual, if not dramatically different approach to business. Its primary commitment, she says, is to Grappones 340 employees. They come first in the mission statement by design. Second, the company seeks lifelong relationships with customers and believes this is best achievable if the sales and service experience is not one of negotiation. This, she says, creates integrity and expectations of consistent treatment. Theres a set price for everything, including financing terms. Everyone pays the same, removing the ether to which she referred in her TEDx speech.

Her sales team does not operate on commissions.

It didnt make sense to race to the bottom on pricing, she says.

Having Toyota as a flagship franchise was helpful; expectations of franchises are reasonable, she says, allowing room for Grappones way.

Always trying to be less wasteful as a company, Osmer said an eighth measure of waste also became a Grappone focus the waste of human creativity. Maybe more than any of the other principles, Osmer emphasizes a workplace that allows innovation to occur. As she describes ways this has been manifested, Ron Malachi, the companys inventory pricing specialist, walks by her office.

He ducks in when asked and rattles off several recent problems a team of folks has solved, including storing extra car inventory at a nearby indoor sports facility.

They get some income, and we get a place (to keep the cars), he says.

Osmer is one of five children born to Robert and Beverly Grappone. Her younger brother, Greg, was her only sibling to be part of the business, eventually becoming the groups chief information officer.

Greg, who had health challenges early in his life, developed cutaneous T-cell lymphoma in his 30s. He found he needed a blood stem cell transplant when the disease turned aggressive.

Osmer was a match for the transplant. Treatment involved eradicating Gregs immune system and injecting new stem cells through a transfusion of Osmers blood. The cancer was killed, but a gruesome side effect graft versus host disease took hold. Osmer described the horrific condition that transpired as one that literally hardened his tissues.

Greg died in 2015, leaving behind a wife and a two-year-old daughter.

In his name, Osmer works on a project that would develop a six-mile abandoned rail line into a new bike and walking path that connects to the Northern Rail trail and would link Concord to Lebanon. It is but one page in her deep portfolio of community work.

She says this involvement in social causes is informed by her familys work.

We were always taught its not about us, she says. Dad just didnt get hung up on material things. I dont get upset when I dont have more things. Its better to express me through how much I help people.

She sees herself as dedicated to serving a lot of people, and it starts with the employees, as the mission suggests.

People need to feel safe; psychological safety, physical safety and having flexibility, she says, describing how the company culture is modeled.

In such an environment, creativity is unleashed, efficiencies are found and people are retained. That environment includes an immaculate, welcoming Toyota dealership building that features a grand piano on its second floor a gift to Osmer from her grandfather.

So, its not a surprise that her team of six directors has more than 140 years of collective service to Grappone.

Away from the dealership, Osmers list of community-service positions is extensive and includes: board member, New Hampshire Public Broadcasting System; corporator, Canterbury Shaker Village; board member, The Endowment for Health; member, Partners for Community Wellness; member, New Hampshire Lemon Law Board; advisory member, Spark New Hampshire; advisory member, Stay Work Play New Hampshire; and advisory member, New Hampshire Charitable Foundations New Hampshire Tomorrow Initiative.

Recently, she became involved in President Donald Birx move to reorganize Plymouth State University into seven educational clusters, beginning this fall. They are: arts and technology; education, democracy and social change; exploration and discovery; health and human enrichment; innovation and entrepreneurship; justice and security; and tourism, environment and sustainable development.

I try to go where I can be most useful, she says, adding she prefers, in many cases, serving one term on a board rather than more to allow broader service.

Osmer lives with her husband, Tom, and three children (two girls and a boy) in a log home in Canterbury. The community, known for its Shaker history, suits her in many ways, from the caring she can expect from the Canterbury Library staff if she drops her son off some afternoon, to the wooded setting that allows her to indulge in trail running, to the neighborly warmth of the Canterbury Fair, recently held.

And, its just the right setting to play her banjo, her instrument of choice.

Osmers is a life being well lived and one seemingly grounded in the words she used to finish her TEDx speech.

So, this is not just about car sales. Its not just about a fourth-generation family business in Bow Junction, New Hampshire, she says. Ask yourselves. Do integrity, kindness and respect form the foundation of all of your relationships, with the people you love the most, with the people you work with, with the people you meet every day? Do they?

If they dont, dont worry about it, she says. Just know that you are under the ether with all of the rest of us. And its time to wake up.

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Re’eh: Sight and vision – Arutz Sheva

August 16th, 2017 10:49 am

The American Declaration of Independence claimed that certain basic human rights were obvious. Yet what is obvious to some is in reality obscure and unknown to many others. Because of this, the Torah emphasizes the obvious in this weeks Torah reading. The choice between death in this world and the next, and life eternal life, no less, should be obvious. The Torah in fact states that seeing this will lead to a correct choice. But one needs to see them objectively and rationally.

People, who make poor choices, do so on the basis of emotion, desire, foolishness and illusory hopes and false ideas. These are the products of distorted vision - the inability to see things clearly. Only clear vision can lead to wise and correct choices. The commandments that the Torah enjoins us to observe are a form of corrective lenses to aid us in seeing things clearly and accurately.

People have to pass an eye and vision test in order to be able to legally operate an automobile. How much more so is an eye and vision test necessary when life and death itself is in question?People have to pass an eye and vision test in order to be able to legally operate an automobile. How much more so is an eye and vision test necessary when life and death itself is in question? The Torah advises us to always choose life. This is the basis for all Jewish society throughout our long and sometimes very painful history. It is obvious that one should always choose life. But we must always be reminded even of the obvious. We should never underestimate the power of distorted vision which causes untold damage to our own selves.

The final gift, so to speak, that the Lord granted to our teacher Moshe was that he was able to see the Land of Israel and the story of the Jewish people throughout history. The Torah teaches us that imagination is a form of seeing. What we see from this is that seeing in the minds eye is also a legitimate form of sight.

The Jewish people survived on the basis of imagination for all of the centuries of our exile and dispersion. We always imagined Jerusalem and the Temple, the Land of Israel and the ingathering of the exiles to their ancient homeland. When imagination wanes, so does our hope and creativity. Of course imagined reality may not completely coincide with the actuality of the human condition and circumstance. But without the original power of imagination of seeing things in our mind and heart and not only with our actual physical eyes one will never advance to actually seeing the desired goal.

That is why the Torah emphasizes time and again the importance of seeing things correctly, both in imaginary and in actual sight. The prophets of Israel fired our imagination with their visions of the future redemption of the Jewish people and humanity generally. We have seen some of these visions fulfilled in our times and in front of our very eyes, if we are but wise enough to see things accurately. The importance of this kind of sight is never to be minimized.

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Pregnant woman loses vision after performing downward yoga pose – The Independent

August 16th, 2017 10:49 am

A pregnant woman lost her vision after performing a downward pose during a prenatal yoga session.

Found to reduce the risk of developing anxiety and depression, as well as providing good preparation for breathing, yoga has long been hailed as a popular form of exercise for women during pregnancy.

But, if a new medical case report is anything to go by, in some cases it could actually do more harm than good.

Revealed in the BMJ Case Reports, a 35-year-old woman at 27 weeks gestation thought to be from Leicester experienced severalweeks of vision loss caused by straining as she stretched into a downward pose.

The position -which causes a rush of blood to the head -is said to be responsible for her valsalva retinopathy (VR).

And, while doctors confirm that VR has been linked with certain yoga exercises such as pranayama - controlled breathing to their knowledge a case like this has not been reported in the literature associated with yoga.

A condition associated with extreme straining, VR is known to occur during labour but can also strike from fairly harmless actions.

While its unclear where the patient attended her class, her VR symptoms are thought to have occurred almost immediately after striking the pose which saw her head being stretched downwards below her bottom.

She was taken to hospital at Leicester Royal Infirmary where doctors noticed a large floater in her left eye.

Fortunately, at a five month follow up it was revealed that the woman had undergone a healthy delivery and that her vision loss had resolved.

Doctors say that prognosis of the bizarre condition is variable, but that the majority of cases report excellent recoveries.

So, is it really safe to practice yoga while pregnant?

Well, according to the NHS keeping up your normal level of exercise during pregnancy is absolutely fine and can actually make it easier for you to adapt to your changing shape.

That being said, pregnant women are advised against contact sports such as scuba diving, judo and exercising at altitude.

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Here’s how you can protect your eyes from damage during the total eclipse – Miami Herald

August 16th, 2017 10:49 am

In two short weeks, the moon will completely cover the sun and the suns atmosphere will be visible. Its a total eclipse, and its what NASA calls one of natures most awe-inspiring sights.

Although those in the Miami area will only see a 72 percent eclipse the path sprawls from Salem, Oregon, to Charleston, South Carolina looking into the partial eclipse can still be dangerous to the naked eye.

Dr. Harry Flynn, a 39-year ophthalmologist at Bascom Palmer Eye Institute in Miami, said the sun rays can cause damage to the eye when it focuses on the retina, burns it and creates a permanent scar in the center of vision.

Flynn said the burn can damage all layers of the retina. The burn often results in permanent and irreversible loss of eyesight.

The reason for this emphasis on eye protection is that people who are uninformed or perhaps children may be fascinated by the event and look at the sun for a period of time without understanding the risk and the potential for damage to their vision, said Flynn, who also teaches about the retina and vitreous at University of Miamis Miller School of Medicine.

Solar damage wipes out macular pigments, which can cause permanent vision loss.

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Business Briefcase published 08-13-17 – Helena Independent Record

August 16th, 2017 10:48 am

Names and faces

Shari Risken has joined Opportunity Bank of Montana as executive assistant to the chief executive officer, chief financial officer and chief risk officer. Shari has an executive assistant degree and more than 35 years of experience with an extensive background providing administrative, technical and analytical services in a wide variety of industries. Her job history includes serving in an executive level administrative position for Shodair Childrens Hospital, Providence Health Care Spokane and Washington Trust Bank.

Ruth Mollet, FNP has joined the gastroenterology department at St. Peters Medical Group North. Prior to this position, Mollet was a Same Day Nurse at St. Peters Hospital. She earned her Masters of Science in Nursing (MSN), with a Family Nurse Practitioner Emphasis, from Devry University, Chamberlain College of Nursing in Chicago. She obtained a Bachelor of Science in Nursing (BSN) from Washington State University Intercollegiate College of Nursing, Joint B.S. degree with Eastern Washington University, in Spokane, Wash.

She is a board certified as a Family Nurse Practitioner with the American Association of Nurse Practitioners.

Christopher Lindsay, M.D., has joined the radiology department at St. Peters Hospital. Lindsay earned his Doctor of Medicine from the Creighton University School of Medicine, in Omaha, Neb. He completed his fellowship in body imaging with the Henry Ford Health System and his residency in diagnostic radiology from Wayne State Universitys Detroit Medical Center in Detroit, Mich. He obtained his bachelor of arts, graduating maxima cum laude, in biology, from Carroll College.

Lindsay is a certified Magnetic Resonance Medical Director from the American Board of Magnetic Resonance Safety (ABMRS). He is also a member of the Radiological Society of North America, the American Roentgen Ray Society, and the American College of Radiology.

Prior to joining St. Peters Hospital, Lindsay was the chief of radiology/radiation oncology section and staff radiologist with St. James Healthcare, in Butte. He also served as a staff radiologist with Montana Interventional and Diagnostic Radiology Specialists, PLLC with the VA Montana Healthcare System in Fort Harrison.

Lindsay is originally from Clancy, and a graduate of Jefferson High School.

Helena native, Dillon Ewals has joined Better Body Fitness as the companys operations director. Ewals will focus on creating a consistent customer experience, as well as streamlining day-to-day operations. His professional experience includes retail store management, sales and account management throughout the U.S.

Mikael Bedell, M.D., has joined St. Peters Medical Group North Clinic. His primary focus is comprehensive outpatient and inpatient family medicine.

Bedell earned his Doctor of Medicine at the Albany Medical College in Albany, N.Y. He received his residency at Idaho State University in Pocatello, Idaho, where he served as chief resident in 1998. He received his bachelor of science, cum laude in animal sciences bioscience and technology from the University of New Hampshire, in Durham, N.H.

He is board certified by the American Board of Family Medicine (ABFM). He serves as a clinical instructor for the Albany Medical College, Department of Family and Community Medicine; the University of Washington, Department of Family Medicine; and as an adjunct faculty for the University of Utah, Department of Family and Preventative Medicine.

Prior to joining St. Peters Hospital, Bedell was a staff physician at the Cascade Medical Center in Cascade, Idaho, where he served as medical director and also on the board of trustees.

Becky Schlauch is the new administrator for the Montana Department of Revenue Liquor Control Division. Schlauch has been in state government for more than seven years, previously working as business and financial services division administrator at the Department of Public Health and Human Services. She also worked for several newspapers in accounting, including as controller for the Helena Independent Record. Schlauch grew up in Circle and earned a bachelors degree in business administration and master of business administration degree from the University of Montana.

Montana Department of Revenue contracts officer Brett Boutin becomes one of just two certified public procurement officers in the state of Montana, after earning his Certified Public Procurement Officer (CPPO) credential. As contracts officer, Boutin manages department contracts to ensure effective and efficient use of public funds. Boutin has a 25-year career in state government.

Doney Crowley P.C. has announced the promotion of Jack Connors to senior associate attorney.

Connors holds a Bachelor of Science degree in mathematics from Montana State University and a Juris Doctorate degree with honors from the University of Montana School of Law. Before attending law school, Connors owned and operated a construction company that specialized in building high-end homes in the Big Sky area. His law practice focuses on construction disputes, real property litigation and water law.

Connors works at the firms Helena office, and he can be contacted at either jconnors@doneylaw.com or 443-2211.

News and notes

Montana producers eligible for hay lottery

Producers in Montana affected by drought and fire are now eligible to participate in the first ever hay lottery. Ag Community Relief, is organizing a large-scale hay donation convoy to North Dakota to aid producers in North Dakota, South Dakota and Montana. The first convoy of hay will be delivered in mid-August but more deliveries could arrive as the group continues to fundraise and seek donations and volunteers. The donated hay will be delivered to North Dakota State University (NDSU) in Fargo, N.D. Any other individuals or organizations willing to donate hay or trucking for the hay lottery should call the North Dakota Department of Agricultures Drought Hotline at 701-425-8454.

Livestock producers interested in applying for the hay lottery must submit an application at https://www.nd.gov/ndda/montana-hay-lottery. Each state has its own lottery, although North Dakota will administer the applications. Eligible producers must be from a D2, D3 or D4 or fire-affected county and own at least 25 animal unit equivalents of state-specific livestock. Eligible livestock and a description of animal unit equivalents may be found directly on each states application. The latest drought monitor depicting the drought levels of specific counties may be found at http://droughtmonitor.unl.edu/.

The application deadline is Aug. 31, 2017.

The hay will be distributed in semi-load lots with the first drawing in early September. If additional donations are taken in after that date, more drawings will occur. Producers that are selected will be responsible for arranging hay transportation from the NDSU site.

Questions about filling out the hay lottery application may be directed to 701-328-4764.

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OBrien leaving tourism alliance

The Helena Tourism Alliance/Tourism Business Improvement District (TBID)/Visit Helena Montana announces the resignation of executive director, Heidi OBrien. OBrien has been with the Tourism Business Improvement District since 2010 and was the organizations first employee. OBrien is moving on to a position with AAA Mountain West. Her last day with the TBID is Aug. 16.

Anna Strange, the current TBID programs coordinator, will help maintain office operations and Jennifer Davis will continue with her role as community outreach director. A nationwide search for a new executive director will be announced in the near future.

The Visitor Information Center located at 105 Reeders Alley will continue operation of normal hours: Monday to Friday, 8 a.m. to 7 p.m. and Saturday 10 a.m. to 2 p.m. through the end of August.

DOR certifies property taxable values

The Montana Department of Revenue has announced it has completed its annual requirement to certify taxable values of property in the states 56 counties. This year, department offices in all 56 counties certified the values before or on the Aug. 7 deadline.

Under state law, the departments property assessment offices are responsible for providing the total taxable value of property to each taxing jurisdiction by the first Monday in August. The certified values include mobile homes, personal property business equipment, real property, and centrally assessed properties.

The 2017 certified taxable values for each county taxing jurisdiction are available at property.mt.gov.

Local governments establish their budgets and set their mill levies for property tax calculations and collections based on the certified taxable values provided to each taxing jurisdiction.

Property tax collections are the primary revenue source for local governments to provide public services such as police and fire protection, schools, roads and bridges, and public health and safety.

Guidelines

The IR welcomes reports of hiring, promotions, awards, recognition, learning opportunities and other news from local companies and nonprofits. We accept press releases and photos (digital images at 300 dpi or more are preferred). Email your information to irstaff@helenair.com.

There is no charge for items appearing in the Business Briefcase. Items are run on a space-available basis, and we reserve the right to edit and use information as we see fit.

The deadline is Tuesday at noon to be considered for publication the following Sunday.

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Smartphone app may help older adults manage serious mental illness and chronic health conditions – Medical Xpress

August 16th, 2017 10:48 am

The use of new technologies in geriatric psychiatry shows promise for advancing personalized medicine and improving patient care. A new study in the American Journal of Geriatric Psychiatry describes the successful adaptation of an integrated medical and psychiatric self-management intervention to a smartphone application for middle-aged and older adults with serious mental illness.

Care of middle-aged and older patients with serious mental illness is complicated. Often these patients suffer from other medical conditions and are at increased risk of premature death. They have two to three times higher health costs than individuals in the general population. In order to help patients cope with their illness, researchers from Dartmouth developed a smartphone-based intervention using an adaptive systems engineering framework and principles of user-centered design. They found that even patients with limited technical abilities could use this App successfully. The App and intervention protocol were developed using commercially available products from Wellframe.

"The use of mobile health interventions by adults with serious mental illness is a promising approach that has been shown to be highly feasible and acceptable," explained lead investigator Karen L. Fortuna, PhD, of the Dartmouth Centers for Health and Aging and the Geisel School of Medicine at Dartmouth. "These technologies are associated with many advantages compared with traditional psychosocial interventions, including the potential for individually tailored, just-in-time delivery along with wide dissemination and high population impact. Nevertheless, the process of adapting an existing psychosocial intervention to a smartphone intervention requires adaptation for a high-risk group with limited health and technology literacy."

Following multiple design iterations, investigators tested the App's usability. Ten participants (mean age of 55.3 years) with serious mental illness and other chronic health conditions reported a high level of usability and satisfaction with the smartphone application.

The App takes patients through 10 sessions over a period of approximately three months, covering topics such as stress vulnerability and illness, medication adherence and strategies, and substance and medication abuse. Physicians can remotely monitor App use, and intervene when problems are detected, facilitating telemedicine for less accessible populations.

According to Dr. Fortuna, "Smartphone applications also potentially facilitate patient engagement in participatory, personalized, and preventative care. As the healthcare industry increasingly embraces prevention and illness self-management, it is important for physicians and patients to be actively involved in designing and developing new technologies supporting these approaches."

The use of smart devices is poised to revolutionize how we think about clinical information and facilitate personalized interventions in a way that could not have been conceptualized before these technologies came into existence. This study is part of a special issue of the American Journal of Geriatric Psychiatry that captures an important moment in the evolving relationship between technology and the clinical care of older adults.

"It has often been noted that with the pace of technology development being so rapid, research may not be able to keep up. While this may be true in the most literal sense, this set of nine papers represents a major step in developing a body of research to guide how technologies can interface with clinical care," noted guest editor Ipsit V. Vahia, MD, McLean Hospital, Belmont, MA, and the Department of Psychiatry, Harvard Medical School, Boston, MA.

These papers highlight the potential of technology based-approaches, provide direction on how this area of work needs to develop, and put a spotlight on the major pitfalls that the field must consider in order for technologies realize their full potential. They also address the relative lack of evidence to date supporting use of these technologies and the lack of clarity on data security and privacy related to use of these devices.

Dr. Vahia continued, "While the potential of technology to impact geriatric psychiatry care in this manner has long been recognized, this issue provides substantial evidence to demonstrate that this potential is translating into reality. Simultaneously, it also makes clear that the work is just getting started."

Explore further: Older adults with severe mental illness challenge healthcare system

More information: Karen L. Whiteman et al, Adapting a Psychosocial Intervention for Smartphone Delivery to Middle-Aged and Older Adults with Serious Mental Illness, The American Journal of Geriatric Psychiatry (2017). DOI: 10.1016/j.jagp.2016.12.007

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CEO Diabetes Wellness Program serves St. Francis – Carbondale News

August 16th, 2017 10:48 am

In recent months, people that suffer from diabetes and that have visited the St. Francis Client Choice Food Pantry in Scranton have been eating better and feeling better. And if all goes according to plan, the healthy trend should continue for years to come.

Last fall, the CEO Weinberg Regional Food Bank began a nine-month Diabetes Wellness Program at the Pantry. The program assisted clients by initially offering hemoglobin A1c screenings (HbA1c) to those with pre-existing diabetic conditions.

These screenings helped CEO nutrition educators determine the baseline of the clients blood/sugar levels. The program then helped such clients with their special dietary needs by providing boxes of healthy foods, twice each month, and by monitoring improvements in their health.

Funded by an AllOne Foundation grant, the program served 50 clients throughout four counties and St. Francis was one of five food pantries served.

We began in September and determined who would be in the program, says Mary Kay DElia, a registered dietitian and certified diabetes educator with CEO.

In October, they started picking up their boxes of healthy foods. Each box featured a recipe, focused on the foods provided that month, and a pantry staple, and condiment to be utilized in that recipe.

"The monthly box also contained handouts about nutrition, food safety, and information on diabetes self-management. And in addition to the monthly box of non-perishables, clients also received fresh produce, milk, eggs, and frozen meat."

In addition to improving clients health, DElia says she hoped that those participating in the program would find it to be empowering.

With diabetes, its always better to teach people to learn to cook at home rather than to eat at fast-food restaurants, she says. That will lower their blood sugar and keep them in control.

Though the program ended on June 30, DElia says that in many ways, it will continue.

We provided exit counseling, she says. We wanted to summarize for the clients all of the lessons that theyve learned throughout the program. Now, were going to turn our mission in another direction and start educating the clients on how to continue making food choices similar to what was in their boxes.

"And we have to educate our food bank staff to order such foods, so that theyll be on the shelves at the pantries.

DElia says that should more grant funding become available, the food box component of the program may return.

Meanwhile, she says diabetic and dietary specialist from CEO will continue to visit St. Francis a few times a year in order to help the clients maintain the good habits theyve learned. Ironically, the St. Francis Client Choice Food Panty had already recently established a Healthy Foods Section as the result of an Eagle Scout project spearheaded by Brandon Kelleher, a member of Boy Scout Troop 160, Clarks Summit.

Thus, DElia feels even more confident that those with diabetes will continue to be properly served at St. Francis. The program, she says, had positive results.

We were able to measure if we made a difference, says DElia. And I was very, very pleased.

Monsignor Joseph P. Kelly, director of St. Francis Kitchen, says there are currently 14 clients at St. Francis being served by the program and there are 32 on its waiting list. He adds that he appreciates the good work that CEO brought to the Food Pantry and that it remains committed to providing healthy foods to all, especially those with special dietary needs.

Food donations needed the most are low sodium items, light syrup, vegetables and fruit.

Having this program at the Food Pantry for the past nine months has been a blessing and a gift to St. Francis and to those that we serve, he says. We plan on continuing to work with CEO and others in the community to insure that such healthy foods remain on our shelves, and we are pleased that as a result of this program, so many of our clients are eating better and feeling better.

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Lack of sleep tied to higher risk of diabetes in kids – Reuters

August 16th, 2017 10:48 am

Reuters Health - Children who dont get enough sleep may be more likely to develop diabetes than kids who typically get enough shuteye, a UK study suggests.

Thats because each additional hour of sleep children get at night is associated with a lower body weight, more lean muscle mass and less accumulation of sugars in the blood, researchers report in Pediatrics. Obesity and elevated blood sugar are risk factors for type 2 diabetes, which happens when the body can't properly use or make enough of the hormone insulin to convert blood sugar into energy.

These findings suggest increasing sleep duration could offer a simple, cost-effective approach to reducing levels of body fat and type 2 diabetes risk early in life, senior study author Christopher Owen of St. Georges, University of London, said by email.

Type 2 diabetes used to be called adult-onset diabetes because it was so rare in children. But today, its a common childhood health problem, in large part because millions of kids worldwide are overweight or obese, dont get enough exercise, and eat too many sugary and fatty foods.

For the current study, researchers examined survey data on sleep habits and lab results from tests of risk factors for diabetes in 4,525 UK children age 9 or 10.

On average, the kids slept 10.5 hours on school nights, although sleep duration ranged from 8 to 12 hours.

Children who got less sleep in the study were more likely to have a risk factor for diabetes known as insulin resistance, when the body doesnt respond normally to the hormone.

Kids who slept less were also more likely to be extremely overweight or obese and have more body fat, the study also found.

Kids 6 to 12 years old should get 9 to 12 hours of sleep a night, according to the American Academy of Pediatrics. Not getting enough sleep is associated with an increased risk of injuries, high blood pressure, obesity and depression.

The study wasnt a controlled experiment designed to prove whether or how insufficient sleep might lead to diabetes in children. Researchers also relied on kids to accurately recall and report what time they went to bed and woke up, which might not accurately reflect how much sleep they really got.

Even so, its possible that insufficient sleep might negatively impact childrens appetites and ability to regulate blood sugar, said Stacey Simon, a pediatric sleep psychologist at the University of Colorado Anschutz Medical Campus and Childrens Hospital Colorado.

When kids are going to bed very late or sleeping on an irregular schedule, they may also be skipping meals, eating at irregular times, or be less likely to exercise during the day, Simon, who wasnt involved in the study, said by email.

Insufficient sleep can affect levels of hormones that control appetite, making kids hungrier and increasing cravings for sweet and salty snacks, said James Gangwisch, a psychiatry researcher at Columbia University in New York who wasnt involved in the study.

Getting enough sleep helps keep our appetite in check and is protective against insulin resistance, Gangwisch said by email.

Beyond making sure kids have regular bedtime, parents should also focus on whats known as sleep hygiene, said Femke Rutters of the VU University Medical Center in Amsterdam.

This can include things like limiting screen time before bed and making sure the bedroom is totally dark at night, Rutters, who wasnt involved in the study, said by email.

SOURCE: bit.ly/2x0TIVI Pediatrics, online August 15, 2017.

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Could Big Lifestyle Changes Be Key to Managing Type 2 Diabetes? – Sioux City Journal

August 16th, 2017 10:48 am

TUESDAY, Aug. 15, 2017 (HealthDay News) -- When it comes to type 2 diabetes management, a new study finds that more is definitely better for lowering blood sugar levels.

The study showed that adding intensive lifestyle management to standard diabetes care (diabetes medication and usual lifestyle change advice) brought blood sugar into a nondiabetic range.

The intensive intervention worked so well that "half of the intervention group did not need glucose-lowering medications to maintain or even improve [blood sugar] control," said the study's senior researcher, Mathias Ried-Larsen.

So, what exactly constitutes an "intensive" intervention?

"Patients were prescribed exercise five to six times per week for 30 to 60 minutes per session. That included both endurance and resistance training," said Ried-Larsen, of Rigshospitalet in Copenhagen, Denmark.

"In the beginning, the exercise was supervised by a coach, but gradually, they were left on their own. Moreover, they received a dietary program with focus on foods rich in fiber, low in saturated fats, lots of fruit and no processed food. We designed the diet for patients to lose weight," he said.

The study included nearly 100 people from Denmark. All had had type 2 diabetes for less than 10 years, and none had complications from the disease.

The average age of the participants was 55, and nearly half were women. Average A1C level at the start of the study was 6.7 percent. A1C is a blood test that estimates average blood sugar levels over two to three months. An A1C of 6.5 percent or higher indicates diabetes, according to the American Diabetes Association.

Study participants were randomly placed into the usual care group or the intensive lifestyle management group.

After a year, the intensive group lost 13 pounds compared to 4 pounds in the standard management group, the findings showed. LDL cholesterol (the bad kind) and triglycerides (another type of bad blood fat) were reduced more in the intensive group than in the standard group. HDL cholesterol (the good kind) rose more in the intensive group than in the standard group, according to the report.

Average A1C dropped from 6.65 to 6.34 percent in the intensive intervention group, and from 6.74 percent to 6.66 percent in the standard group, the investigators found.

In addition, three-quarters of those in the intensive group needed less diabetes medication, while only one-quarter of the standard care group lowered their medications, the researchers reported.

Not every expert agrees that lowering or stopping diabetes medications is a good idea, however.

Dr. Joel Zonszein is director of the clinical diabetes center at Montefiore Medical Center in New York City.

Zonszein noted that study participants were taking metformin and GLP-1 analogues. "These are good agents. That's why their A1C was so good at the start. I also treat my patients with lifestyle changes. But it's not one or the other. Both medicine and lifestyle changes are important," he said.

"When you use the two together, they work much better," he added.

Zonszein also noted that the Denmark group was "an unusual population." None took insulin, and no one had complications. And, at the start of the study, their blood sugar was already fairly well-managed. That would likely be much different in a U.S. population with type 2 diabetes.

One reason Ried-Larsen hoped to lower the need for medication is to save money. Although metformin is available in a generic form and isn't generally expensive, some of the newer type 2 diabetes medications can be costly.

"I think this study calls for a thorough discussion about the resources we need to allocate to help people to adhere to a lifestyle treatment and what responsibility the society has in this regard," Ried-Larsen said.

"We do acknowledge that the lifestyle treatment is extensive and could be regarded as not economically viable in clinical care," Ried-Larsen noted. "However, consider the willingness to introduce newer classes of drugs that come with extreme prices. If we could get doctors and patients to allocate that sort of money and resources to lifestyle treatment, I think we could change things."

Zonszein added that when people rely solely on lifestyle management, it doesn't always bring blood sugar levels down enough.

"It's important to consider the cost-effectiveness of medications along with their cost. A lot of expense comes from treating diabetes complications," he said.

The report was published Aug. 15 in the Journal of the American Medical Association.

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Could Big Lifestyle Changes Be Key to Managing Type 2 Diabetes? - Sioux City Journal

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Tandem Diabetes launches clinical trial for its automatic insulin delivery suspension – MobiHealthNews

August 16th, 2017 10:48 am

Touchscreen insulin pump maker Tandem Diabetes announced a new clinical trial for an insulin pump with apredictive low glucose suspend (PLGS) algorithm. Another step on the road to an artificial pancreas, PLGS allows Tandem to automatically suspend insulin delivery when it predicts low glucose and resume it when glucose starts to rise again.

The start of this pivotal trial is another important step forward in our automated insulin delivery programs, and comes on the heels of very encouraging feasibility study data, Kim Blickenstaff, president and CEO of Tandem Diabetes Care, said in a statement. We remain on track to submit our t:slim X2 Pump with predictive low glucose suspend to the FDA in early 2018. Subject to FDA approval, we are preparing to launch in summer of 2018, and plan to make this new feature accessible for existing t:slim X2 customers via a remote software update using our Tandem Device Updater.

The pivotal trial, which is part of the data Tandem needs to collect for its FDA submission, will include 90 participants at 6 research centers around the country. Participants will be randomized into two groups that will each be monitored for three weeks as they manage their insulin at home. Both groups will use at:slim X2 Pump from Tandem and a Dexcom G5 continuous glucose monitor, but one will have PLGS enabled while the other will not.

The primary outcome measure of the study will be glucose sensor values, and the secondary outcome measures include glucose control and instances of hypo- and hyperglycemia.

"Mild to moderate hypoglycemia occurs frequently during the day for people with Type 1 diabetes, but of more concern is the severe hypoglycemia which can occur at night causing seizures or even death," principal investigator Dr. Bruce Buckingham said in a statement. "This is a real concern to all people living with Type 1 diabetes, and especially parents of children with Type 1. This new PLGS algorithm will allow for the automatic suspension of insulin delivery when glucose is predicted to be low. This is beneficial throughout the day, but can be lifesaving at night when a person is otherwise unable to react.

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Tandem Diabetes launches clinical trial for its automatic insulin delivery suspension - MobiHealthNews

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