StemCell Therapy

Our Licensed Optometrists perform eye exams for eyeglasses and contact lenses, and provide care for minor eye emergencies and dry eye problems. Our Board Certified Ophthalmologists specialize in the diagnosis and treatment of glaucoma, diabetic eye disease, age related macular degeneration (AMD), along with many other eye diseases and eye emergencies. They perform cataract surgery & lens implants including near vision correcting multifocal lens implants and astigmatism correcting toric lens implants for vision correction after cataract surgery. Our eye specialists also offer laser eye surgery such as LASIK for those who prefer clearer vision without having to depend on glasses or contact lenses. To help you look your best Center for Sight provides eye plastic surgery including blepharoplasty eyelid surgery or eyelifts. All of these specialized eye care services are offered by our Fellowship trained Corneal Surgeon, Retinal Specialist and Oculoplastic Surgeon.

Our Optical Shop offers the best quality eyewear in Massachusetts and Rhode Island, with attention to personal care and service. Our team of Registered Dispensing Opticians have been assisting patients in their selection of eyeglasses in the Massachusetts and Rhode Island area for over 25 years. We offer a large selection of the latest designer eyewear and high definition digital lenses, including digital progressives, as well as a value line of eyeglass frames to fit into any budget. We strongly recommend protecting your eyes from the damaging rays of the sun. To help our patients in protecting their eyes, we offer a wide variety of sunglasses, all of which offer a 100% UV protection.

Read more from the original source:
Center For Sight

The Lions Sight and Tissue Foundation of District 2-X1 Inc.(LS&TF) has been serving the citizens of the Dallas area from its beginning in 1956 as an eye bank devoted to cataract surgery and cornea transplantation to its current purpose as a resource for the people in District 2-X1 (which includes the Counties of Dallas, Ellis, Hunt, Rockwall, Kaufman & parts of Collin) to receive eyeglasses as well as medical assistance for vision issues.

Through the years, the LS&TF has grown from a few dedicated volunteers meeting a plane at the airport at midnight to deliver corneas to a person in need, to an organization staffed by volunteers from Lions Clubs all over District 2-X1. Utilizing a state-of-the-art Mobile Clinic equipped with all the modern equipment needed to provide complete eye exams the LS&TF reaches out to children and adults who need vision care but lack the resources for such care.

The impact of this service on the lives of these children and adults is profound. Without glasses, children are less likely to succeed in school, leading to drop-outs, gang involvement, and potential incarceration. Vision problems are 3 times as likely in Juvenile Detention Centers as in the general population.For adults, having a pair of glasses can mean the difference in getting a job or becoming a drain on societys resources. The sense of pride in becoming self-sufficient can change their lives.

LS&TF is a Lions Club District 2-X1 Charity. As a 501(c)(3), all contributions made are tax deductible under law. We welcome all donations and would be glad to discuss our work with any group or individual who is interested. Only through the generous donations of Lions Clubs, Foundations, Corporations and individuals can the important work of the LS&TF continue to help the people of District 2-X1.

Thank you. As Lions, We Serve.

Read the original:
Lions Sight and Tissue Foundation

Feeding your body certain foods may help keep your immune system strong. If you're looking for ways to prevent winter colds and the flu, your first step should be a visit to your local grocery store. Plan your meals to include these 15 powerful immune system boosters.

Most people turn to vitamin C after they've caught a cold. Thats because it helps build up your immune system. Vitamin C is thought to increase the production of white blood cells. These are key to fighting infections.

Popular citrus fruits include:

Because your body doesn't produce or store it, you need daily vitamin C for continued health. Almost all citrus fruits are high in vitamin C. With such a variety to choose from, it's easy to add a squeeze of this vitamin to any meal.

If you think citrus fruits have the most vitamin C of any fruit or vegetable, think again. Ounce for ounce, red bell peppers contain twice as much vitamin C as citrus. Theyre also a rich source of beta carotene. Besides boosting your immune system, vitamin C may help maintain healthy skin. Beta carotene helps keep your eyes and skin healthy.

Broccoli is supercharged with vitamins and minerals. Packed with vitamins A, C, and E, as well as many other antioxidants and fiber, broccoli is one of the healthiest vegetables you can put on your table. The key to keeping its power intact is to cook it as little as possible or better yet, not at all.

Garlic is found in almost every cuisine in the world. It adds a little zing to food and it's a must-have for your health. Early civilizations recognized its value in fighting infections. According to the National Center for Complementary and Integrative Health, garlic may also help lower blood pressure and slow down hardening of the arteries. Garlics immune-boosting properties seem to come from a heavy concentration of sulfur-containing compounds, such as allicin.

Ginger is another ingredient many turn to after getting sick. Ginger may help decrease inflammation, which can help reduce a sore throat and other inflammatory illnesses. Ginger may also help decrease nausea. While it's used in many sweet desserts, ginger packs some heat in the form of gingerol, a relative of capsaicin. Ginger may help decrease chronic pain and may possess cholesterol-lowering properties, according to recent animal research.

Spinach made our list not just because it's rich in vitamin C. It's also packed with numerous antioxidants and beta carotene, which may increase the infection-fighting ability of our immune systems. Similar to broccoli, spinach is healthiest when its cooked as little as possible so that it retains its nutrients. However, light cooking enhances its vitamin A and allows other nutrients to be released from oxalic acid.

Try one of our favorite healthy spinach recipes!

Look for yogurts that have "live and active cultures" printed on the label, like Greek yogurt. These cultures may stimulate your immune system to help fight diseases. Try to get plain yogurts rather than the kinds that are preflavored and loaded with sugar. You can sweeten plain yogurt yourself with healthy fruits instead.

Yogurt can also be a great source of vitamin D, so try to select brands fortified with vitamin D. Vitamin D helps regulate the immune system and is thought to boost our bodys natural defenses against diseases.

When it comes to preventing and fighting off colds, vitamin E tends to take a backseat to vitamin C. However, vitamin E is key to a healthy immune system. Its a fat-soluble vitamin, meaning it requires the presence of fat to be absorbed properly. Nuts, such as almonds, are packed with the vitamin and also have healthy fats. A half-cup serving, which is about 46 whole, shelled almonds, provides nearly 100 percent of the recommended daily amount of vitamin E.

Both green and black teas are packed with flavonoids, a type of antioxidant. Where green tea really excels is in its levels of epigallocatechin gallate, or EGCG, another powerful antioxidant. EGCG has been shown to enhance immune function. The fermentation process black tea goes through destroys a lot of the EGCG. Green tea, on the other hand, is steamed and not fermented, so the EGCG is preserved.

Green tea is also a good source of the amino acid L-theanine. L-theanine may aid in the production of germ-fighting compounds in your T-cells.

Papaya is another fruit loaded with vitamin C. You can find 224 percent of the daily recommended amount of vitamin C in a single papaya. Papayas also have a digestive enzyme called papain that has anti-inflammatory effects.

Papayas have decent amounts of potassium, B vitamins, and folate, all of which are beneficial to your overall health.

Like papayas, kiwis are naturally full of a ton of essential nutrients, including folate, potassium, vitamin K, and vitamin C. Vitamin C boosts white blood cells to fight infection, while kiwis other nutrients keep the rest of your body functioning properly.

When youre sick, chicken soup is more than just a feel-good food with a placebo effect. It helps improve symptoms of a cold and also helps protect you from getting sick in the first place. Poultry, such as chicken and turkey, is high in vitamin B-6. About 3 ounces of light turkey or chicken meat contains 40 to 50 percent of your daily recommended amount of B-6.

Vitamin B-6 is an important player in many of the chemical reactions that happen in the body. Its also vital to the formation of new and healthy red blood cells. Stock or broth made by boiling chicken bones contains gelatin, chondroitin, and other nutrients helpful for gut healing and immunity.

Sunflower seeds are full of nutrients, including phosphorous, magnesium, and vitamin B-6. Theyre also incredibly high in vitamin E, with 82 percent of the daily recommended amount in just a quarter-cup serving.

Vitamin E is a powerful antioxidant. Its important in regulating and maintaining immune system function. Other foods with high amounts of vitamin E include avocados and dark leafy greens.

Shellfish isnt what jumps to mind for many who are trying to boost their immune system, but some types of shellfish are packed with zinc.

Zinc doesnt get as much attention as many other vitamins and minerals, but our bodies need it so that our immune cells can function as intended.

Varieties of shellfish that are high in zinc include:

Keep in mind that you dont want to have more than the daily recommended amount of zinc in your diet. For adult men, its 11 milligrams (mg), and for women, its 8 mg. Too much zinc can actually inhibit immune system function.

Eating right is a great start, and there are other things you can do to protect you and your family from the flu, cold, and other illnesses. Start with these flu prevention basics and then read these seven tips for flu-proofing your home. Perhaps most importantly, read up on the flu vaccine and decide whether its right for you.

Originally posted here:
15 Foods That Boost the Immune System

While 21 million people have been diagnosed with diabetes, there are about 8.1 million people who are walking around with the disease and don't know it (27.8 percent of people with diabetes are undiagnosed). Symptoms of diabetes vary from person to person. But, the earlier you catch them, the better it is for your overall health and diabetes care.

It is worth getting to know, and keeping a lookout for, the symptoms of diabetesespecially if any of the below already apply to you.

If you are experiencing any of the following, you should be seen by your primary care doctor as soon as possible.

Polyuria (Excessive Urination)Polyuria is defined as an increase in the frequency of urination. When you have abnormally high levels of sugar in your blood, your kidneys draw in water from your tissues to dilute that sugar, so that your body can get rid of it through the urine. The cells are also pumping water into the bloodstream to help flush out sugar, and the kidneys are unable to reabsorb this fluid during filtering, which results in excess urination.

To meet the clinical definition of polyuria, urine output for an adult must exceed 2.5 liters per day (normal urine output is 1.5 liters per day).

As it's pretty hard for you to measure this yourself, simply note if you're visiting the restroom far more often than usual and/if you're staying there longer when you do.

Polydipsia (Excessive Thirst)Excessive thirst typically goes hand-in-hand with increased urination. As your body pulls water out of the tissues to dilute your blood and to rid your body of sugar through the urine, the urge to drink increases. Many people describe this thirst as an unquenchable one. To stay hydrated, you drink excessive amounts of liquids. And if those liquids contain simple sugars (soda, sweet iced tea, lemonade, or juice, for example) your sugars will skyrocket even higher.

Extreme FatigueYour body is like a carit needs fuel to function. Its primary source of fuel is glucose (sugar), which is gained from foods that contain carbohydrates that get broken down. Insulin, a hormone produced by the pancreas, takes sugar from your blood to your cells to use for energy. However, when you have diabetes, either your pancreas isn't making enough insulin or the insulin that your body is making isn't being used the way it's supposed to be, typically because the cells become resistant to it.

This results in your cells becoming deprived of sugar, or fuel. The result: tiredness and extreme fatigue. This often gets misunderstood as hunger, and people eat more.

Polyphasia (Excessive Hunger)Excessive hunger goes hand-in-hand with fatigue and cell starvation. Because the cells are resistant to the body's insulin, glucose remains in the blood. The cells are then unable to gain access to glucose, which can trigger hunger hormones that tell the brain that you are hungry. Excessive eating can complicate things further by causing blood sugars to increase.

NeuropathyNumbness, tingling, or "pins and needles" in the extremities is referred to as neuropathy. Neuropathy is usually a symptom that occurs gradually over time as excess sugar damages the nerves. Keeping blood sugars within normal range can help prevent further damage and reduce symptoms. People with severe symptoms may receive medication.

Cuts and Bruises That are Slow to HealWhen the blood is thick with sugar, nerves and circulation can be affected.

Adequate circulation is needed to heal. Poor circulation can make it hard for blood to reach affected areas, slowing down the healing process. If you notice that you've had a cut or bruise that is very slow to go away, this could be a sign of high blood sugars.

Blurry VisionBlurred vision can result from elevated blood sugar. Similarly, fluid that is pulled from the cells into the bloodstream to dilute the sugar can also be pulled from the lenses of your eyes. When the lens of the eye becomes dry, the eye is unable to focus, resulting in blurry vision. It's important that all people diagnosed with type 2 diabetes have a dilated eye exam shortly after diagnosis. Damage to the eye can even occur before a diagnosis of diabetes exists.

These symptoms are not experienced by everyone with diabetes, but they can signal the disease and are worth being aware of:

The same tests used to screen and diagnose diabetes are used to detect individuals with pre-diabetes. There are a few ways to get diagnosed. Your doctor can choose to do a variety of blood tests, depending on whether or not you have symptoms. Whether you are at low or high risk for diabetes, your physician will use these same tests:

Sometimes people don't experience symptoms of diabetes and the diagnosis is made not because a doctor necessarily suspects the disease, but as the result of a routine check-up.

For someone who is not having any symptoms to be considered to have type 2 diabetes, he or she must:

For someone who is having symptoms of type 2 diabetes, he or she can have any of the above test results or a random blood sugar of 200mg/dL or higher.

According to the American Diabetes 2016 Clinical Guidelines, unless the patient is experiencing symptoms, tests should be repeated using a new blood sample to confirm a diagnosis.

If you've just been diagnosed with diabetes, it is normal to feel scared, confused, and overwhelmed. There are so many myths out there about diabetes, which can certainly make coping more difficult. Try not to listen to things other people have to say, such as, you can never eat carbohydrates again. Instead, get educated.

Talk with your doctor about connecting with a certified diabetes educator and receiving diabetes self-management education. Learning about what to eat, what your medicines do, and how to test your blood sugars are just some of the things these resources can help with. Educators can also dispel myths, create meal plans, coordinate other doctors appointments for you, and listen to your needs. They are trained to teach using a patient-centered approach. They are your advocates who specialize in diabetes. Ask your doctor today or go to the American Association of Diabetes Educators website to find someone near you. Be sure to call your insurance company to see if these services are covered, too.

We give you special kudos for managing your condition, as it is not always easy. If you've had diabetes for a long time, it's normal to burn out sometimes. You may get tired of your day to day tasks, such as counting carbohydrates or measuring your blood sugar. Lean on a loved one or a friend for support, or consider talking to someone else who has diabetes who can provide, perhaps, an even more understanding ear or ideas that can help you.

If you find that you are a little rusty and could use a refresher course in nutrition or anything else related to diabetes, consider signing up for a diabetes conversation map class. These classes are a good way to re-learn key components of diabetes in a group setting. If you have adequate knowledge and are instead looking for ways to make your life easier, check out some apps, nutrition resources, or fitness trackers that can help you stay moving and cook healthy meals. Keeping up the good work is worth it, as it can help prevent complications.

If, on the other hand, you are already starting to develop complications or your medication regimen has changed because your blood sugars are getting higher, remember that diabetes is a progressive diseaseand sometimes these things just happen without any influence from your own actions. As you age, beta cells in the pancreas get tired and stop working. If you've had diabetes for 20 years and now need to start insulin, for example, it doesn't mean you've failed. It just means that your body needs some help. Make sure you continue to receive education and that you continue to have someone to lean on when you need it, and keep the lines of communication open with your doctor. It truly can make a difference.

Getting diagnosed with diabetes can be shocking, but the good news is that, although it is a disease you must deal with daily, it is a manageable one. If you are experiencing any of the above symptoms, especially if you are someone who is at high risk, you should meet with your primary care physician to get tested. The earlier a diagnosis is made, the more likely you can get your diabetes under control and prevent complications.

And remember not to let others scare you into thinking the worst. Getting educated will help you to understand that a diabetes diagnosis, while serious, is not the end of the world. For some people, lifestyle modifications such as weight loss, healthy eating, and exercise can actually get blood sugars below the diabetes threshold. You can control your diabetes and not let it control you.

Here is the original post:
Type 2 Diabetes Symptoms - verywellhealth.com

Dr. Whipple's Biography Dr. Whipple is a native Hoosier who grew up on the northwest side of Indianapolis, where he graduated from Pike High School. He attended Indiana University, graduating with highest distinction with a double major in biology and chemistry. While at Indiana, he was elected to the Phi Beta Kappa Society. Dr. Whipple received his M.D. degree from the Indiana University School of Medicine in 1988. He completed a year of general medical training at St. Vincent Hospital in Indianapolis before completing his specialty training in ophthalmology at Henry Ford Hospital in Detroit, Michigan. Dr. Whipple opened his practice in Avon in July, 1992. Dr. Whipple is board certified by the American Board of Ophthalmology. He is an active member of the AAO, ASCRS, and the American Association of Physicians and Surgeons. Dr. Whipple served on the board of directors of the Indiana Academy of Ophthalmology from 1997-2008, the board of directors of Prevent Blindness Indiana from 2006-2009, and the Hibbeln Surgery Center board from 2001-2009. He currently serves on the board of directors of the Hendricks County Community Foundation where he has served since 2005, serving as board President in 2008 and 2009. Dr. Whipple is also part of the teaching faculty within the department of Ophthalmology at the IU School of Medicine where he regularly taught cataract surgery from 1996-2001. He currently is a clinical instructor of Ophthalmology at the IU School of Medicine. Dr. Whipple's wife, Libby Givan Whipple, grew up in Plainfield and is a graduate of the Indiana University School of Law, Indianapolis. Dan and Libby have four children, Jack, Katie, Joe and Mark. Libby and Katie share a love for art and their work adorns our waiting room. Jack, Joe, and Mark enjoy golfing with their dad. They live in Avon and are members of Fairfield Friends Meeting in Camby.

View original post here:
Ophthalmologists near Indianapolis, IN - Eye Surgeon

We look forward to becoming your partner in accessing and improving your optimal health and well being. At Integrative Medicine of New Jersey our team invites you to take a step into a new world- a world of possibility; a world of good health and well being; a world where you are given the tools to take charge of your own health.

Our goal is to provide a road map to help you navigate through health problems within an entirely new vision, one that allows you to understand and address the cause of disease and ill health rather than just treating the symptoms.

Dr. Sherman and her team at Integrative Medicine of New Jersey specialize in Integrative Medicine, Bio-Therapeutics, Family Wellness and Primary Care. She has an open minded and eclectic approach to evaluating and treating her patients utilizing the resources of Conventional and Integrative medicine and the evolving scientific medical developments.

The center offers the people of Montclair, NJ state of the art medical advances and technology and is dedicated to Preventative Care Management, Allergies and Asthma, Auto-Immune Diseases, Gastrointestinal Health, Neurological Conditions, ADD, ADHD, Autism, Pain Management, Endocrine Disorders, Anti-Aging, Hormonal Imbalances, and Acute Illnesses.

Our Integrative approach to medicine utilizes natural, non-invasive therapies in conjunction with traditional approaches designed individually for each patient. These therapies focus on optimal lifestyle choices for each specific condition and include Nutrition/Diet Counseling, Sleep and Exercise Recommendations, Supplementation, Herbal Medicines, and Homeopathy.

Integrative Medicine of New Jersey offers Bio-Identical Hormone Replacement therapies, Nutritional Bio- Chemistry, Heavy Metal Toxicity, IV therapies, and Comprehensive Detoxification programs. Non-Invasive Cosmetic Treatments are also offered. These treatments include Holistic Facial Rejuvenation, Wrinkle Reduction, Hair Removal, Anti-Aging Non-Surgical Face Lifts, Sophisticated Laser therapies and Spider Vein Rejuvenation.

Our process begins with a thorough review of your medical history, an examination, and testing and investigational analysis in our on-site laboratory. This specifically entails a detailed conversation about your current state of your health, health history, family history, diet, lifestyle habits etc. Based on our findings, Dr. Sherman will then create a comprehensive program designed especially for you.

Part of our commitment to you, is to provide as much information as possible about good health, healing and your well-being. We encourage you to come to your appointment with a list of detailed questions, goals, all previous blood work and diagnostics from other physicians and outside labs, and current medications including all vitamins and nutritional supplements. This will allow us to help you solve problems more efficiently and enhance the quality of your care.

For your convenience we have included a contact sheet for your personal files as well as Integrative Medicine of New Jersey Best Practices to insure a successful visit. If you have any further questions concerning our process, treatments and or administrative issues, please contact one of our Integrative Care Patient Representatives. We have reserved a special time to help you with your health concerns. If you cannot make your scheduled appointment, please contact us as soon as possible to re-schedule your time. We have a 48 hour cancellation policy.

It is a pleasure welcoming the people of Montclair, NJ to our practice and the opportunity to experience the medicine of the future.

Best,Dr. Rimma L. Sherman, DirectorIntegrative Medicine of New Jersey

Chance favors the prepared mind. ~Louis Pasteur

Read the original here:
Integrative Medicine of New Jersey | Montclair, NJ ...

Stem cell, an undifferentiated cell that can divide to produce some offspring cells that continue as stem cells and some cells that are destined to differentiate (become specialized). Stem cells are an ongoing source of the differentiated cells that make up the tissues and organs of animals and plants. There is great interest in stem cells because they have potential in the development of therapies for replacing defective or damaged cells resulting from a variety of disorders and injuries, such as Parkinson disease, heart disease, and diabetes. There are two major types of stem cells: embryonic stem cells and adult stem cells, which are also called tissue stem cells.

Read More on This Topic

cardiovascular disease: Cardiac stem cells

Cardiac stem cells, which have the ability to differentiate (specialize) into mature heart cells and therefore could be used to repair damaged or diseased heart tissue, have garnered significant interest in the development of treatments for heart disease and cardiac defects. Cardiac stem

Embryonic stem cells (often referred to as ES cells) are stem cells that are derived from the inner cell mass of a mammalian embryo at a very early stage of development, when it is composed of a hollow sphere of dividing cells (a blastocyst). Embryonic stem cells from human embryos and from embryos of certain other mammalian species can be grown in tissue culture.

The most-studied embryonic stem cells are mouse embryonic stem cells, which were first reported in 1981. This type of stem cell can be cultured indefinitely in the presence of leukemia inhibitory factor (LIF), a glycoprotein cytokine. If cultured mouse embryonic stem cells are injected into an early mouse embryo at the blastocyst stage, they will become integrated into the embryo and produce cells that differentiate into most or all of the tissue types that subsequently develop. This ability to repopulate mouse embryos is the key defining feature of embryonic stem cells, and because of it they are considered to be pluripotentthat is, able to give rise to any cell type of the adult organism. If the embryonic stem cells are kept in culture in the absence of LIF, they will differentiate into embryoid bodies, which somewhat resemble early mouse embryos at the egg-cylinder stage, with embryonic stem cells inside an outer layer of endoderm. If embryonic stem cells are grafted into an adult mouse, they will develop into a type of tumour called a teratoma, which contains a variety of differentiated tissue types.

Mouse embryonic stem cells are widely used to create genetically modified mice. This is done by introducing new genes into embryonic stem cells in tissue culture, selecting the particular genetic variant that is desired, and then inserting the genetically modified cells into mouse embryos. The resulting chimeric mice are composed partly of host cells and partly of the donor embryonic stem cells. As long as some of the chimeric mice have germ cells (sperm or eggs) that have been derived from the embryonic stem cells, it is possible to breed a line of mice that have the same genetic constitution as the embryonic stem cells and therefore incorporate the genetic modification that was made in vitro. This method has been used to produce thousands of new genetic lines of mice. In many such genetic lines, individual genes have been ablated in order to study their biological function; in others, genes have been introduced that have the same mutations that are found in various human genetic diseases. These mouse models for human disease are used in research to investigate both the pathology of the disease and new methods for therapy.

Extensive experience with mouse embryonic stem cells made it possible for scientists to grow human embryonic stem cells from early human embryos, and the first human stem cell line was created in 1998. Human embryonic stem cells are in many respects similar to mouse embryonic stem cells, but they do not require LIF for their maintenance. The human embryonic stem cells form a wide variety of differentiated tissues in vitro, and they form teratomas when grafted into immunosuppressed mice. It is not known whether the cells can colonize all the tissues of a human embryo, but it is presumed from their other properties that they are indeed pluripotent cells, and they therefore are regarded as a possible source of differentiated cells for cell therapythe replacement of a patients defective cell type with healthy cells. Large quantities of cells, such as dopamine-secreting neurons for the treatment of Parkinson disease and insulin-secreting pancreatic beta cells for the treatment of diabetes, could be produced from embryonic stem cells for cell transplantation. Cells for this purpose have previously been obtainable only from sources in very limited supply, such as the pancreatic beta cells obtained from the cadavers of human organ donors.

The use of human embryonic stem cells evokes ethical concerns, because the blastocyst-stage embryos are destroyed in the process of obtaining the stem cells. The embryos from which stem cells have been obtained are produced through in vitro fertilization, and people who consider preimplantation human embryos to be human beings generally believe that such work is morally wrong. Others accept it because they regard the blastocysts to be simply balls of cells, and human cells used in laboratories have not previously been accorded any special moral or legal status. Moreover, it is known that none of the cells of the inner cell mass are exclusively destined to become part of the embryo itselfall of the cells contribute some or all of their cell offspring to the placenta, which also has not been accorded any special legal status. The divergence of views on this issue is illustrated by the fact that the use of human embryonic stem cells is allowed in some countries and prohibited in others.

In 2009 the U.S. Food and Drug Administration approved the first clinical trial designed to test a human embryonic stem cell-based therapy, but the trial was halted in late 2011 because of a lack of funding and a change in lead American biotech company Gerons business directives. The therapy to be tested was known as GRNOPC1, which consisted of progenitor cells (partially differentiated cells) that, once inside the body, matured into neural cells known as oligodendrocytes. The oligodendrocyte progenitors of GRNOPC1 were derived from human embryonic stem cells. The therapy was designed for the restoration of nerve function in persons suffering from acute spinal cord injury.

Embryonic germ (EG) cells, derived from primordial germ cells found in the gonadal ridge of a late embryo, have many of the properties of embryonic stem cells. The primordial germ cells in an embryo develop into stem cells that in an adult generate the reproductive gametes (sperm or eggs). In mice and humans it is possible to grow embryonic germ cells in tissue culture with the appropriate growth factorsnamely, LIF and another cytokine called fibroblast growth factor.

Some tissues in the adult body, such as the epidermis of the skin, the lining of the small intestine, and bone marrow, undergo continuous cellular turnover. They contain stem cells, which persist indefinitely, and a much larger number of transit amplifying cells, which arise from the stem cells and divide a finite number of times until they become differentiated. The stem cells exist in niches formed by other cells, which secrete substances that keep the stem cells alive and active. Some types of tissue, such as liver tissue, show minimal cell division or undergo cell division only when injured. In such tissues there is probably no special stem-cell population, and any cell can participate in tissue regeneration when required.

The epidermis of the skin contains layers of cells called keratinocytes. Only the basal layer, next to the dermis, contains cells that divide. A number of these cells are stem cells, but the majority are transit amplifying cells. The keratinocytes slowly move outward through the epidermis as they mature, and they eventually die and are sloughed off at the surface of the skin. The epithelium of the small intestine forms projections called villi, which are interspersed with small pits called crypts. The dividing cells are located in the crypts, with the stem cells lying near the base of each crypt. Cells are continuously produced in the crypts, migrate onto the villi, and are eventually shed into the lumen of the intestine. As they migrate, they differentiate into the cell types characteristic of the intestinal epithelium.

Bone marrow contains cells called hematopoietic stem cells, which generate all the cell types of the blood and the immune system. Hematopoietic stem cells are also found in small numbers in peripheral blood and in larger numbers in umbilical cord blood. In bone marrow, hematopoietic stem cells are anchored to osteoblasts of the trabecular bone and to blood vessels. They generate progeny that can become lymphocytes, granulocytes, red blood cells, and certain other cell types, depending on the balance of growth factors in their immediate environment.

Work with experimental animals has shown that transplants of hematopoietic stem cells can occasionally colonize other tissues, with the transplanted cells becoming neurons, muscle cells, or epithelia. The degree to which transplanted hematopoietic stem cells are able to colonize other tissues is exceedingly small. Despite this, the use of hematopoietic stem cell transplants is being explored for conditions such as heart disease or autoimmune disorders. It is an especially attractive option for those opposed to the use of embryonic stem cells.

Bone marrow transplants (also known as bone marrow grafts) represent a type of stem cell therapy that is in common use. They are used to allow cancer patients to survive otherwise lethal doses of radiation therapy or chemotherapy that destroy the stem cells in bone marrow. For this procedure, the patients own marrow is harvested before the cancer treatment and is then reinfused into the body after treatment. The hematopoietic stem cells of the transplant colonize the damaged marrow and eventually repopulate the blood and the immune system with functional cells. Bone marrow transplants are also often carried out between individuals (allograft). In this case the grafted marrow has some beneficial antitumour effect. Risks associated with bone marrow allografts include rejection of the graft by the patients immune system and reaction of immune cells of the graft against the patients tissues (graft-versus-host disease).

Bone marrow is a source for mesenchymal stem cells (sometimes called marrow stromal cells, or MSCs), which are precursors to non-hematopoietic stem cells that have the potential to differentiate into several different types of cells, including cells that form bone, muscle, and connective tissue. In cell cultures, bone-marrow-derived mesenchymal stem cells demonstrate pluripotency when exposed to substances that influence cell differentiation. Harnessing these pluripotent properties has become highly valuable in the generation of transplantable tissues and organs. In 2008 scientists used mesenchymal stem cells to bioengineer a section of trachea that was transplanted into a woman whose upper airway had been severely damaged by tuberculosis. The stem cells were derived from the womans bone marrow, cultured in a laboratory, and used for tissue engineering. In the engineering process, a donor trachea was stripped of its interior and exterior cell linings, leaving behind a trachea scaffold of connective tissue. The stem cells derived from the recipient were then used to recolonize the interior of the scaffold, and normal epithelial cells, also isolated from the recipient, were used to recolonize the exterior of the trachea. The use of the recipients own cells to populate the trachea scaffold prevented immune rejection and eliminated the need for immunosuppression therapy. The transplant, which was successful, was the first of its kind.

Research has shown that there are also stem cells in the brain. In mammals very few new neurons are formed after birth, but some neurons in the olfactory bulbs and in the hippocampus are continually being formed. These neurons arise from neural stem cells, which can be cultured in vitro in the form of neurospheressmall cell clusters that contain stem cells and some of their progeny. This type of stem cell is being studied for use in cell therapy to treat Parkinson disease and other forms of neurodegeneration or traumatic damage to the central nervous system.

Following experiments in animals, including those used to create Dolly the sheep, there has been much discussion about the use of somatic cell nuclear transfer (SCNT) to create pluripotent human cells. In SCNT the nucleus of a somatic cell (a fully differentiated cell, excluding germ cells), which contains the majority of the cells DNA (deoxyribonucleic acid), is removed and transferred into an unfertilized egg cell that has had its own nuclear DNA removed. The egg cell is grown in culture until it reaches the blastocyst stage. The inner cell mass is then removed from the egg, and the cells are grown in culture to form an embryonic stem cell line (generations of cells originating from the same group of parent cells). These cells can then be stimulated to differentiate into various types of cells needed for transplantation. Since these cells would be genetically identical to the original donor, they could be used to treat the donor with no problems of immune rejection. Scientists generated human embryonic stem cells successfully from SCNT human embryos for the first time in 2013.

While promising, the generation and use of SCNT-derived embryonic stem cells is controversial for several reasons. One is that SCNT can require more than a dozen eggs before one egg successfully produces embryonic stem cells. Human eggs are in short supply, and there are many legal and ethical problems associated with egg donation. There are also unknown risks involved with transplanting SCNT-derived stem cells into humans, because the mechanism by which the unfertilized egg is able to reprogram the nuclear DNA of a differentiated cell is not entirely understood. In addition, SCNT is commonly used to produce clones of animals (such as Dolly). Although the cloning of humans is currently illegal throughout the world, the egg cell that contains nuclear DNA from an adult cell could in theory be implanted into a womans uterus and come to term as an actual cloned human. Thus, there exists strong opposition among some groups to the use of SCNT to generate human embryonic stem cells.

Due to the ethical and moral issues surrounding the use of embryonic stem cells, scientists have searched for ways to reprogram adult somatic cells. Studies of cell fusion, in which differentiated adult somatic cells grown in culture with embryonic stem cells fuse with the stem cells and acquire embryonic stem-cell-like properties, led to the idea that specific genes could reprogram differentiated adult cells. An advantage of cell fusion is that it relies on existing embryonic stem cells instead of eggs. However, fused cells stimulate an immune response when transplanted into humans, which leads to transplant rejection. As a result, research has become increasingly focused on the genes and proteins capable of reprogramming adult cells to a pluripotent state. In order to make adult cells pluripotent without fusing them to embryonic stem cells, regulatory genes that induce pluripotency must be introduced into the nuclei of adult cells. To do this, adult cells are grown in cell culture, and specific combinations of regulatory genes are inserted into retroviruses (viruses that convert RNA [ribonucleic acid] into DNA), which are then introduced to the culture medium. The retroviruses transport the RNA of the regulatory genes into the nuclei of the adult cells, where the genes are then incorporated into the DNA of the cells. About 1 out of every 10,000 cells acquires embryonic stem cell properties. Although the mechanism is still uncertain, it is clear that some of the genes confer embryonic stem cell properties by means of the regulation of numerous other genes. Adult cells that become reprogrammed in this way are known as induced pluripotent stem cells (iPS).

Similar to embryonic stem cells, induced pluripotent stem cells can be stimulated to differentiate into select types of cells that could in principle be used for disease-specific treatments. In addition, the generation of induced pluripotent stem cells from the adult cells of patients affected by genetic diseases can be used to model the diseases in the laboratory. For example, in 2008 researchers isolated skin cells from a child with an inherited neurological disease called spinal muscular atrophy and then reprogrammed these cells into induced pluripotent stem cells. The reprogrammed cells retained the disease genotype of the adult cells and were stimulated to differentiate into motor neurons that displayed functional insufficiencies associated with spinal muscular atrophy. By recapitulating the disease in the laboratory, scientists were able to study closely the cellular changes that occurred as the disease progressed. Such models promise not only to improve scientists understanding of genetic diseases but also to facilitate the development of new therapeutic strategies tailored to each type of genetic disease.

In 2009 scientists successfully generated retinal cells of the human eye by reprogramming adult skin cells. This advance enabled detailed investigation of the embryonic development of retinal cells and opened avenues for the generation of novel therapies for eye diseases. The production of retinal cells from reprogrammed skin cells may be particularly useful in the treatment of retinitis pigmentosa, which is characterized by the progressive degeneration of the retina, eventually leading to night blindness and other complications of vision. Although retinal cells also have been produced from human embryonic stem cells, induced pluripotency represents a less controversial approach. Scientists have also explored the possibility of combining induced pluripotent stem cell technology with gene therapy, which would be of value particularly for patients with genetic disease who would benefit from autologous transplantation.

Researchers have also been able to generate cardiac stem cells for the treatment of certain forms of heart disease through the process of dedifferentiation, in which mature heart cells are stimulated to revert to stem cells. The first attempt at the transplantation of autologous cardiac stem cells was performed in 2009, when doctors isolated heart tissue from a patient, cultured the tissue in a laboratory, stimulated cell dedifferentiation, and then reinfused the cardiac stem cells directly into the patients heart. A similar study involving 14 patients who underwent cardiac bypass surgery followed by cardiac stem cell transplantation was reported in 2011. More than three months after stem cell transplantation, the patients experienced a slight but detectable improvement in heart function.

Patient-specific induced pluripotent stem cells and dedifferentiated cells are highly valuable in terms of their therapeutic applications because they are unlikely to be rejected by the immune system. However, before induced pluripotent stem cells can be used to treat human diseases, researchers must find a way to introduce the active reprogramming genes without using retroviruses, which can cause diseases such as leukemia in humans. A possible alternative to the use of retroviruses to transport regulatory genes into the nuclei of adult cells is the use of plasmids, which are less tumourigenic than viruses.

See the article here:
stem cell | Definition, Types, Uses, Research, & Facts ...

Overview

Over the past decade, significant advances in genetic testing and technologies have altered the clinical management of individuals. Advances in genetic testing are also accompanied by a string of new challenges related to the ethical, legal, and social issues (ELSI) for our society.

Genomic advancements in testing and diagnosis often outpace the development of therapeutic treatments. Although largely unsupported by professional medical associations, private companies continue to promote genetic tests to the public (direct-to-consumer tests). As primary care providers grasp the new implications of genetic and genomic advances, an understanding of ELSI will allow them to anticipate these new challenges and provide better care for their patients.

Research has found that a frequent barrier to practicing genetic medicine in a primary care setting is that providers are unsure how to provide adequate information and support to their patients, particularly in the areas of ELSI. Since PCP are frequently first to interact with patients seeking genetic information, they are encouraged to review resources to better equip them for these sensitive interactions.

Medical Advantages: New Genetic Tests & Navigating Ethical Considerations

The AAP surveyed its members regarding trends that will impact the future of pediatrics as part of a large-scale forecasting and strategic planning effort. One of the 8 megatrends identified from this effort was that of ongoing medical advances -- with genomics and gene therapies being specifically mentioned. The value of medical advances for helping to treat and/or eliminate life-threatening illnesses was recognized. It was also noted that it may be difficult for providers to keep up with the accelerated advancements. Some challenges include validating, translating, and integrating new knowledge into practice. It is critical for the PCP to review and understand the ethical considerations inherent to new technologies and treatments.

Pediatrics in the Year 2020 and Beyond: Preparing for Plausible Futures.Published: Pediatrics, November 2010Authors: AJ Starmer, JCDuby, KMSlaw, AEdwards, LKLeslie, and Members of the Vision of Pediatrics 2020 Task Force

Social, Legal, and Ethical Considerations of Genomics

Genetic Testing in Children

Advances in genetic research hold particular promise in the diagnosis and treatment of childhood diseases. Unfortunately, the rate of new developments in testing and screening often outpaces the formulation of treatment and preventive therapies -- in some cases leaving no room for improved management and care delivery for these patients. Providers -- and their patients -- should be aware of the potential risks associated with genetic testing on children.

The AAP Committee on Bioethics has issued a statement on Ethical Issues with Genetic Testing in Pediatrics. This statement reviews considerations for the use of genetic technology for newborn screening, carrier testing, and testing for susceptibility to late-onset conditions. The statement provides recommendations for promoting informed participation by parents for newborn screening and limited use of carrier testing and testing for late-onset conditions in the pediatric population.

The AMA Guidelines offer principles to guide appropriate decision making for genetic testing of children.

Testing Children for Adult-Onset Genetic DiseasesThe Committee on Bioethics of the AAP advises against genetic testing of children for conditions that have their onset in adulthood. However, patients may seek genetic testing of their children especially for situations in which a genetic disease is known to be present in the family for a variety of reasons. These requests create a dilemma for pediatricians; in particular because adult-onset diseases, and their interventions, differ from condition to condition. The publication, Testing Children for Adult-Onset Genetic Diseases, offers case examples and strategies for providers faced with this dilemma.

Next-generation sequencing technologies, including whole-genome and whole-exome sequencing will be increasingly more common in pediatric research. One consequence of these new technologies is the increased likelihood of "The Incidentalome." This refers to the identification of individual genomic research finding that are incidental to the original purpose of testing by chance when sequencing large parts of the genome. While many believe that there is some duty to disclose individual genetic research results to research subjects, the issue is further complicated for pediatric patients due to the nature of personal decision making and the effects of being informed of adult-onset conditions at a young age. An article by Khan, Badgett, and colleagues explores this issue further in Disclosure of Incidental Findings from Next-Generation Sequencing in Pediatric Genomic Research.

Informed Consent

With the exception of state-mandated newborn screening, all genetic tests are voluntary. Testing for genetic conditions can be complex and genetic tests have many limitations. A positive result does not necessarily confirm a diagnosis, and a negative result does not always rule out the condition. Due to limitations in technology, genetic testing may lead to unanticipated results.

Genetic testing often requires obtaining informed consent from the patient or guardian, and many times this form is provided by the laboratory testing company or the providers medical institution.

Visit Columbia University's Department of Pathology and Cell Biology Web site for examples of genetic testing informed consent forms. These, or similar, requisitions include the reasons for ordering testing and the implications of each possible test result for the patient.

The Genetic Information Nondiscrimination Act (GINA) was passed in May 2008 and went into effect November 2009. GINA was created to address the concern that a persons genetic information could be used against someone in health insurance and employment decisions. This fear has been cited as a significant barrier for patients to obtain a genetic test.

As a result of GINA, group and individual health insurers cannot use a persons genetic information to:

Employers cannot use a persons genetic information to:

Limitations of GINA:

The following resources can assist providers and families to understand the benefits and limitations of GINA legislation and be able to assist families in navigating these issues:

Resources

eDoctoring offers 25 simulated clinical cases, 15 interactive tutorials, and a virtual library containing numerous articles, fast facts, and video clips arranged in the following content areas:

Users may select from pre-organized CME courses (6 or 12 hour courses), or build their own learning course with cases and tutorials of particular interest to them.

"Genetic Dilemmas in Primary Care" an educational program about the medical and ethical challenges raised by genetic testing in primary care practiceThe Genetic Dilemmas program is designed for family physicians, internists, obstetricians and gynecologists, pediatricians and advance practice nurses, as well as other primary care clinicians. It includes a one hour case-based videotape and a printed Viewers Guide, discussion points, and an annotated resource list. This project -- funded by a grant from the National Institutes of Health -- was created in cooperation with The Hastings Center and Columbia University, College of Physicians and Surgeons. Goals of the educational activity include:

World Health Organization (WHO)WHO's Human Genetics program aims to provide information and raises awareness within the health sector, government, and public on the health challenges and opportunities within the new and rapidly developing science of human genetics. The WHO ELSI Web site overviews the issues and concerns around human genetics and public health, and, in particular, addresses ELSI of genetics.

The WHO published guidelines for health care professionals entitled, Proposed International Guidelines on Ethical Issues in Medical Genetics and Genetic Services. The guidelines are based on general principles of medical ethics including respect for the autonomy of persons, beneficence, non-malfeasance, and justice.

Managing incidental and pertinent findings from WGS in the 100,000 Genome ProjectA discussion paper from the Foundation for Genomics and Population Health, April 2013Authors: Allison Hall, Nina Hallowell, and Ron Zimmern

Cultural Competence

Practicing culturally competent care as part of a medical home is particularly important in regards to genetic medicine due to increased sensitivity to ethical issues and cultural differences. Within genetic medicine, issues of consanguinity, ethnicity, and patient confidentiality are issues with a particular need for enhanced understanding and competence by the provider.

Resources

The Genetic Counseling Cultural Competence Toolkit (GCCCT) was made possible through the Jane Engelberg Memorial Fellowship grant and the National Society of Genetic Counselors to improve the delivery of culturally responsive, client-centered genetic counseling to diverse populations and to reduce health disparities. The cases provide structure for self-reflection, skills development, and consideration of various approaches for dealing with different cultures and health beliefs. The toolkit includes 9 cases, each linked fundamentally to the genetic counseling process and explores issues of culture(s) and/or language(s) in the context of one step in the genetic counseling process.

Tell us what you think! Take this 3-5 minute survey to provide us with your feedback to inform future update to the site.

Here is the original post:
Ethical-Legal-and-Social-Issues - aap.org

Dental stem cell companies are companies that preserve the valuable cells contained with dental structures.While stem cells from teeth have not yet been approved for therapeutic use in humans, there is great potential for their future use within regenerative medicine applications.

In this article:

Simply put, dental stem cell companies collect and preserve cells from teeth.Dental pulp is the soft living tissue inside a tooth that contains adult stem cells. The ideal time to harvest dental stem cells is when children lose their baby teeth through natural loss or extraction by a dentist.

Although dental pulp gets the most attention, there are stem cell and progenitor cells present in other oral structures as well.

Five different types of dental stem cells have been discovered, which include:

The following are the companies offeringdentalstem cells storage as part of a diversified stem cell storage approach. Each of these companies was created as a cord blood bank to collect and store the blood present in a newborns umbilical cord, because this blood contains a rich population of stem cells.

Similar to cord blood banking, dental stem cell banking involves stem cell collection, processing, and long-term storage. Therefore, it is an excellent service addition for many cord blood banks, including:

In addition, specialty companies also exist that focus exclusively on dentalstem cell storage.

The major players in this area include:

While there are many other small providers of tooth stem cell storage, the companies listed above account formore than 80% of the total market share, according to estimates by BioInformant.

Below, five leading dental stem cell companies are profiled and their storage services explained.

BioEden began offering tooth stem cell storage as early as 2006[1], making it one of the earliest known providers of dental stem cell storage. Read our interview withTony Veverka, Chief Group Executive of BioEden.

Precious Cells Group (PCG) got into dental stem cell banking by entering into a strategic alliance to provide processing, laboratory and regulatory undertakings on behalf of Bioeden in the U.K.

Unfortunately, PCG went out of businessin March 2018 and no longer offers dental stem cell storage services.

The National Dental Pulp Laboratory launched in 2007[2].

Originally, the company was formed in the early 1970s as a cryogenic laboratory specializing in fertility work. In the mid 1990]s, it began preserving stem cells from umbilical cord blood, and today, it also offers storage for the stem cells found in teeth.

According to Stemade, it is thefirst and largest private dental stem cell storage company in India.[3] The company has also served areas of Asia since 2013 [4].Stemade licenses their dental storage technology fromInstitut Clinident Biopharma, which it describes as offering a technical solution to the collection and preservation of the dental pulp, rich in adult stem cells[5]. TheInstitut Clinident Biopharma also licenses its technology to European companies as well.

There is also ReeLabs[6], a major enterprise forstem cell storage in India,banking cells from over ten human sources. To learn more about ReeLabs, read our interview withDr. Abhijit Bopardikar, Director.

Clearly, the regions that are currentlymost active in offering dental stem cell storage are the United States, India, and the United Kingdom, respectively.

If you found this blog valuable, subscribe to BioInformants stem cell industry updates.

What other questions do you have regarding tooth stem cells and dental stem cell companies? Mention them in the comments below.

Footnotes[1] Us.bioeden.com, (1963). About BioEden Inc | Stem cells | Tooth stem cell storage bank. [online] Available at: http://us.bioeden.com/about/ [Accessed 4 Nov. 2014].[2] Ndpl.net,. National Dental Pulp Laboratory | Preserving Dental Stem Cells. N.p., 2015. Web. 19 Sept. 2015.[3] Stemade.com,. Stemade Indias First & Largest Dental Stem Cell Bank. N.p., 2015. Web. 01 Dec. 2015.[4] Biospectrumasia.com,. Asias First Dental Stem Cell Bank Is Here. N.p., 2015. Web. 02 Dec. 2015.[5] Stemade.com/about/partners,. Stemade Partner. N.p., 2015. Web. 01 Dec. 2015.[6] Reelabs.com,. Stem Cell Banking & Therapy In India | Reelabs. N.p., 2015. Web. 18 Dec. 2015.

Guide To Dental Stem Cell Companies | Tooth Stem Cells

Read more here:
Guide To Dental Stem Cell Companies | Tooth Stem Cells

Gene therapy, the use of genetic material to treat a disease or disorder, is making strides in muscular dystrophy. Although the approach is still considered experimental, studies in animal models have shown promising results and clinical trials in humans are underway.

Gene therapy has the potential to help people with inherited disorders, in which a gene mutation causes cells to produce a defective protein or no protein at all, leading to disease symptoms.

To deliver the genetic material to the cells, scientists use a tool called a vector. This is typically a virus that has been modified so that it doesnt cause disease. It is hoped that the vector will carry the therapeutic gene into the cells nucleus, where it will provide the instructions necessary to make the desired protein.

The most common form of muscular dystrophy, Duchenne muscular dystrophy, is caused by a mutation in the DMD gene, which codes for a protein called dystrophin. Dystrophin is part of a protein complex that strengthens and protects muscle fibers. When the cells dont have functional dystrophin due to the gene mutation, muscles progressively weaken. Scientists think that supplying a gene that codes for a functional form of dystrophin might be an effective treatment for Duchenne muscular dystrophy.

Using gene therapy to deliver a correct form of the dystrophin gene has been challenging because of the size of the DMD gene, which is the largest gene in the human genome so it does not fit into commonly used vectors.

Scientists are having more success with a shortened version of the DMD gene that produces a protein called micro-dystrophin. Even though its a smaller version of dystrophin, micro-dystrophin includes key elements of the protein and is functional.

Administering a gene for micro-dystrophin to golden retriever dogs that naturally develop muscular dystrophy showed promising results in a study published in July 2017. Muscular dystrophy symptoms were reduced for more than two years following the treatment and the dogs muscle strength improved. The gene was delivered using a recombinant adeno-associated virus, or rAAV, as the vector.

A similar therapy is now being tested in people in a Phase 1/2 clinical trial (NCT03375164)at Nationwide Childrens Hospital in Columbus, Ohio. A single dose of the gene therapytreatment containing the gene encoding for micro-dystrophinwill be infused into the blood system of 12 patients in two age groups: 3 months to 3 years, and 4 to 7 years. The first patient in the trial, which is recruiting participants, already has received the treatment, according to a January 2018 press release.

The biopharmaceutical company Sarepta Therapeutics is contributing funding and other support to the project.

Sarepta is developing another potential gene therapy for Duchenne muscular dystrophy where rather than targeting the DMD gene that codes for dystrophin, the therapy will be used to try to increase the expression of a gene called GALGT2. The overproduction of this gene is thought to produce changes in muscle cell proteins that strengthen them and protect them from damage, even in the absence of functional dystrophin.

A Phase 1/2a clinical trial (NCT03333590) was launched in November 2017 at Nationwide Childrens Hospital for the therapy, called rAAVrh74.MCK.GALGT2.

***

Muscular Dystrophy Newsis strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

Read the original post:
Gene Therapy in Muscular Dystrophy

The Stem Cell Procedure

Optimal Health Medical, LLC uses adult autologous stem cells, meaning that they are derived and taken from your own body, which avoids the possibility of rejection. A simple in-office procedure a called a bone marrow aspiration is performed to obtain your own stem cells.

HOW IS BONE MARROW ASPIRATION PERFORMED?

Bone marrow is extracted from the back of a patients pelvis called the posterior iliac crest.

The doctor will inject a local anesthetic (numbing agent), to prevent discomfort and pain. Bone Marrow aspiration involves one small incision in the skin to introduce the bone marrow needle for aspiration. You may experience some discomfort during the procedure, but it is brief, and if needed more local anesthesia will be provided.

HOW LONG IS THE PROCEDURE?

The actual extraction takes just a couple of 2 minutes. The full procedure and visit will take up to a couple of hours. During that time the handling of the bone marrow sample will include separating the red blood cells, and placing the sample in a centrifuge for its final preparation for injection back into the body.

Utilizing the most advanced technique for stem cell injection, the doctor will perform what is called a Guided Stem Cell Injection. Guided injection stem cell treatments are done by the doctor using a portable ultrasound machine, positioned to allow the doctor to see the needle as he guides it to the area to be injected.

IS THE PROCEDURE SAFE?

Bone marrow aspirations are safe when properly performed in a sterile environment. Complications are rare but can include:

The risks of a bone marrow aspirate include the following: pain or temporary discomfort and/or bruise at the site of the puncture. Post-procedure treatment guidelines will be provided in the initial consultation.

HOW LONG IS THE RECOVERY TIME?

Most patients are able to return to basic daily activities in 3 days but some pain may be felt at the aspiration site for up to 1 week. Return to exercise or sports or which place on the joint may take several weeks, and guided by the doctor on an individualized basis.

Read the original:
Stem Cell Therapy - Dr Sobo, Stamford CT

Stem cell therapy is an exciting area of research that holds tremendous potential for helping chronic pain patients reduce their pain. Rapid advances in this field of medicine are buoying doctors and patients hopes that the exciting therapy could change lives. Advances are being made nearly every day, and as scientists further understand the nature of these cells, even more uses for them are becoming known. If youve ever wondered about how stem cell therapy for pain could help you, these 15 questions delve into how this therapy works and who it could be used for.

Science has a strong interest in stem cells because of their renewing properties and the ability of these cells to develop into any type of tissue in the body of the organism. Researchers believe that they have the potential for immeasurable clinical uses in health. Research is advancing many stem cell based therapies for people who suffer from diseases such as:

Mayo Clinic explains how this therapy works:

Stem cell therapy, also known as regenerative medicine, promotes the reparative response of diseased, dysfunctional or injured tissue using stem cells or their derivativesResearchers grow stem cells in a lab. These stem cells are manipulated to specialize into specific types of cells, such as heart muscle cells, blood cells or nerve cells. The specialized cells can then be implanted into a person.

Stem cell therapy is actually a type of treatment within the larger umbrella of regenerative medicine. Our longer post on regenerative medicine discusses the types of treatments available, including stem cell therapy and platelet-rich plasma injections.

Stem cells are essentially blank canvases that can transform into any type of cell in the human body. Specialized cells like bone cells, liver cells, and heart cells begin as stem cells. The process of the cells transforming from blank slates into specialized cells is called differentiation.

Stem cell therapy is the process of injecting these cells into damaged areas of the body, such as arthritic knees or shoulders. The stem cells then differentiate into damaged tissue, helping to regenerate the entire area.

There are two different types of natural stem cells and one that is genetically reprogrammed within the laboratory. Embryonic stem cells are the most immature and are found within the early stages of a growing embryo, usually after it has been left to develop five to six days. After the egg and sperm have united, the fertilized egg divides and creates stem cells that differentiate into the specialized cells the body requires to function. Many techniques using stem cells for pain therapies no longer rely on these types of stem cells.

The second type of stem cell, found naturally in organisms, is adult stem cells. These are present in developed tissue, such as muscle, skin, bone, brain, and blood. Also called tissue stem cells, they can self-renew and generate one specialized cell type. Under normal circumstances these tissue stem cells, or adult stem cells, will generate the type of cells that make up the organ in which they reside. These cells are used by the body to divide and repair injured areas or regenerate into specialized cells to replace the ones that are dead or damaged.

The third type of stem cells, which are genetically reprogrammed in the laboratory, are induced pluripotent stem cells. After years of stem cell research and development, it was discovered that artificially triggering certain genetic components would prompt different cells to become pluripotent stem cells, which were similar in nature to embryonic stem cells. This helps avoid ethical concerns associated with using human embryonic tissue for research and regenerative medicine.

The following video from an Arizona pain doctor goes into detail about how stem cell therapy for pain works.

There are twomajor types of stem cells: those harvested from adults and those harvested from embryonic tissues.

However, there are other ways to retrieve stem cells that reduce the use of embryonic stem cells, including:

As the Euro Stem Cell organization reports, some of these types of stem cells are more effective than others.

One source of stem cells is human embryos. These cells are called pluripotent stem cells, and theyre very useful to researchers because they can be multiplied indefinitely in the laboratory. Although these cells are often cultivated from embryos that are just a few days old, they can also be taken from fetal tissue thats older than eight weeks, according to the National Institutes of Health (NIH).

The majority of therapeutic stem cells come from adults. Even though embryos are the richest source of stem cells, humans of all ages have stem cells. Stem cells give adults the ability to replace damaged tissue, heal wounds, and grow hair.The patients own adult stem cells are extracted, purified, concentrated, and then injected into the damaged tissue. This process is usually non-surgical and the individual has very little recovery time. Most patients report only some soreness around the site of the injection. Sometimes there is also slight bruising. There have been no reports of serious side effects from treatments using stem cell therapy.

Newer research has given scientists the ability to reprogram specialized adult cells so they essentially return to their original stem cell state. These reprogrammed cells are known as induced pluripotent stem cells. Although this ability exists, scientists arent sure how or if these artificially created stem cells behave differently than other types.

Despite these unknowns, the reprogrammed stem cells are already being used in the development of medicines and helping scientists learn more about specific types of diseases, according to NIH.

Stem cells have many uses, and the full spectrum of their application isnt yet known. One way stem cells are helping researchers is by illuminating the inner workings of various diseases. Stem cells offer scientists the ability to model human disease progression in a laboratory setting.

This is exciting because many studies rely on animals with similar, but not exact, biology to humans. The more scientists can understand about human-specific disease progression, the greater insight they have regarding potential treatments.

For example, one of the earliest uses for stem cells were bone marrow transplants, used to help patients with leukemia or sickle cell anemia heal. This treatment has been used for more than 40 years. In addition, stem cell therapy may be used to treat:

The application of most interest to chronicpatients is likely the emerging field of regenerative medicine, which is the science of helping tissues regenerate. This field examines the potential of stem cells to repair damaged tissue and heal areas of the body bone and potentially organs, too affected by arthritis, diabetes, spinal cord injuries, nerve damage, Parkinsons disease, and more.

Exciting research has also uncovered the potential for stem cells to expand the number of lungs available for transplant. A portion of lungs available for transplant arent used because they become damaged. However, research from the American Physiological Society has found stem cells could help repair the organs and prepare them to save lives.

Other recent researchstories include:

For many of the studies underway, time is needed to fully examine the benefits and potential dangers of this treatment. Another obstacle is obtaining specific types of adult stem cells. Theyre difficult to grow in the laboratory, making it hard to produce the large numbers available for research.

Another potential issue with donor stem cells is the possibility of rejection. The immune system of the recipient could reject the cells, essentially making it difficult for the treatment to work as intended and causing ancillary problems.

Finally, since this is such a new treatment area, some government agencies are calling for more oversight of its use. Others are pushing back, claiming that stem cell therapy provides a new area of treatment for patients who have exhausted all other options.

That being said, even though there are complications and roadblocks to its use, the benefits of stem cell therapy could be huge. As the American Academy of Anti-Aging Medicine notes:

[A]n analysis of the potential benefits of stem cells based therapies indicates that 128 million people in the United States alone may benefit with the largest impact on patients with Cardiovascular disorders (5.5 million), autoimmune disorders (35 million) and diabetes (16 million US patients and more than 217 million worldwide).

Californias Stem Cell Agency gives a great overview of this process, noting:

In order to be approved by the FDA for use in human trials, stem cells must be grown in good manufacturing practice (GMP) conditions. Under GMP standards, a cell line has to be manufactured so that each group of cells is grown in an identical, repeatable, sterile environment. This ensures that each batch of cells has the same properties, and each person getting a stem cell therapy gets an equivalent treatment. Although the FDA hasnt yet issued guidelines for how pluripotent stem cells need to meet GMP standards, achieving this level of consistency could mean knowing the exact identity and quantity of every component involved in growing the cells.

Stem cell therapy is being studied for a number of chronic pain conditions, especiallypain in the:

Stem cell therapy for pain could help reduce the inflammation that results in chronic pain, or it could help to heal regenerative conditions that lead to pain, such as arthritis.

Using stem cell therapy for knee pain is one of the leading areas of research. Stem cell therapy for knees can be provided as stem cell injections or as blood platelet treatments from the body itself (another form of regenerative medicine).These two treatments may help relieve pain associated with:

The leading researchers on stem cell therapy for knee pain claim that it can help patients avoid surgery, with its associated costs and risks.

Since stem cell therapy promises to treat a number of conditions related to degenerative conditions, like arthritis and tendonitis, stem cell therapy may present a great treat option for hip pain related to these causes.

The National Multiple Sclerosis Society is leading the efforts in research, but currently reports the following:

At present, there are no approved stem cell therapies for MS. Larger, longer-term, controlled studies are needed to determine the safety and effectiveness of using stem cells to treat MS. When the results of these and subsequent clinical trials are available, it should be possible to determine what the optimal cells, delivery methods, safety and actual effectiveness of these current experimental therapies might be for different people with MS.

Potentially. One of our sister clinics, Arizona Pain, is participating in a study evaluating the potential of stem cells to reduce back pain related to degenerative disc disease. This progressive condition sometimes results from injury, but other times has no clear cause.

The study is exciting because it involves stem cells harvested from the bone marrow of healthy, young adults, and therefore itdoesnt come with the ethical concerns of embryonic stem cells. So far, the results have been very positive, and a significant number of people who received stem cells for their back pain have experienced reduced discomfort and improved quality of life.

This study is currently in Phase III, which is the phase immediately preceding potential FDA approval. This means it could soon be available to many more patients and potentially covered by insurance, although each insurance companys coverage policy varies.

Absolutely, and the research into this area is very promising. In fact, scientists have recently uncovered the specific type of stem cell most likely to reduce arthritis pain. Theyre special cells that are specifically able to rebuild tissue, bone, and cartilage, potentially offering much relief to osteoarthritis patients.

What other questions do you have regarding stem cell therapy for pain? If youre ready to learn more about using stem cell therapy to treatyour pain, click the button below to find a pain specialist in your area.

See the original post here:
15 Stem Cell Therapy For Pain Questions, Answered

Brain Death Reversed With Stem Cells

Stem cells have the potential to be used to treat and better understand some of the worlds most deadly and disabling diseases.

The Big Q: Who is not interested in new ways to apply stem cell therapy?

The Big A: We are and have opened our Tatget 150 clinic in Bangkok, Thailand to apply this growing, life extending science.

We have recently heard about scientists in Philadelphia, PA, USA who have been injecting stem cells directly into the spinal cords of medically brain-dead people in order to revive them.

The idea of bringing people back from the dead is a little too much for some critics to manage.

In March 2017, researchers at the biotech company,Bioquark,got approval to begin a clinical trial with 20 test patients to see if neural brain damage could be reversed.

TheBioquarkwebsite says the research and development organization is a life sciences company developing proprietary combinatorial biologic products for both the regeneration and repair of human organs and tissues, as well as the reversion of a range of chronic degenerative diseases.

Integrating regenerative biology, evolutionary genomics, and bio-cybernetics, the futurists are offering death-resisting treatments: a set of novel bio-products capable of directly remodeling diseased, damaged, or aged tissues.

These achievements alone sound compelling, Yes?

But, then when adding the potential of restoring brain function to a lifeless mind and the appeal goes up, way up.

Bioquarkgot the federal nod t go ahead with their Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury study, slated to begin in July 2018. Youll note theres no mention of raising the dead at this point.

The study participants will not be injected with stem cells. that is just the 1st step of this experimental treatment. Next, a peptide formula will be injected into the spinal cord. This is supposed to help new neurons grow. Finally, a 15-day course of nerve stimulation and laser therapy will be administered, to stimulate neurons to form connections.

The main diagnostic tool is the electroencephalogram (EEG) which measures brainwaves and records them for future review. EEG results will be used to determine if the therapy is working or not.

Diffuse axonal injury (DAI) is a type of traumatic brain injury. It happens when the brain suddenly and swiftly shifts inside the skull while an injury is happening. The axons (long connecting fibers) in the brain are sheared when the brain smacks against the skull and bounces back, accelerating and decelerating rapidly.

DAI commonly damages many parts of the brain, to the extent that DAI patients are typically in a coma state. The main symptom is loss of consciousness, which usually lasts no more than six hours or so. But even if a person comes out of a comatose state, there may be signs of brain damage such as:

This multi-pronged treatment that combines injections of stem cells and chemical formulas with nerve stimulation is brand new and already attracting controversy.

Some of the debate has nothing to do with morality or ethics, but talk about the way to sign up a study participant who has been pronounced legally dead.

Most US state laws define death as the irreversible loss of heart and lung or brain function.

The Big Qs 2&3: If the researchers are successful in restoring brainwaves to an inactive mind, will the patients personality and memories be restored intact? Will the individual be in a mental condition comparable to what the person had before the traumatic brain injury?

The Big As 2&3:

Dr. Ed Cooper, an orthopedic surgeon involved in the study, gave Zero odds for success because the procedure must act on a functional brain stem which connects most of the motor neurons to the cerebral cortex.

But Ira Pastor, Bioquarks CEO, agreed with his colleague, Dr. Cooper in principle but gave hope for a positive outcome because there is a small nest of cells that continue to operate in brain-dead patients.

Dr. Pastor is an optimist about restoring brain activity in comatose or brain-damaged patients. I just think its a matter of putting it all together and getting the right people and the right minds on it, he said.

Dr. Charles Cox, a pediatric surgeon at the University of Texas Health Science Center at Houston who has researched the kind of stem cells used in the Bioquark trial, echoed Dr. Coopers reservations: I think reviving someone would technically be a miracle. I think the Pope would technically call that a miracle.

Eat healthy, Be healthy, Live lively

brain, cells, dead, injury, loss, miracle, neurons, patients, Pope, restoring, reversed, stem, study

Paul A. Ebeling, polymath, excels in diverse fields of knowledge. Pattern Recognition Analyst in Equities, Commodities and Foreign Exchange and author of The Red Roadmasters Technical Report on the US Major Market Indices, a highly regarded, weekly financial market letter, he is also a philosopher, issuing insights on a wide range of subjects to a following of over 250,000 cohorts. An international audience of opinion makers, business leaders, and global organizations recognizes Ebeling as an expert.

Continue reading here:
Brain Death Reversed with Stem Cells - Live Trading News

Who isnt interested in new ways to apply stem cell therapy these days?

Speaking of, have you heard about the scientists in Philadelphia, PA, who have been injecting stem cells directly into the spinal cords of medically brain-dead people in order to revive them?

In a page taken from Mary Shelleys Frankenstein, the idea of bringing people back from the dead is a little too much like playing God for some critics to appreciate.

In March 2017, researchers at the biotech company, Bioquark, got approval to begin a clinical trial with 20 test patients to see if neural brain damage could be reversed.

The Bioquark website says the research and development organization is a life sciences company developing proprietary combinatorial biologic products for both the regeneration and repair of human organs and tissues, as well as the reversion of a range of chronic degenerative diseases.

Integrating regenerative biology, evolutionary genomics, and bio-cybernetics, the futurists are offering death-resisting treatments: a set of novel bio-products capable of directly remodeling diseased, damaged, or aged tissues.

These achievements alone sound pretty compelling. But toss in restoring brain function to a lifeless mind and the appeal goes way up.

Bioquark got the federal nod t go ahead with their Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury study, slated to begin in July 2018. Youll note theres no mention of raising the dead at this point.

The study participants will not be injected with stem cells thats just the first step of this experimental treatment. Next, a peptide formula will be injected into the spinal cord. This is supposed to help new neurons grow. Finally, a 15-day course of nerve stimulation and laser therapy will be administered, to stimulate neurons to form connections.

The main diagnostic tool is the electroencephalogram (EEG) which measures brainwaves and records them for future review. EEG results will be used to determine if the therapy is working or not.

Diffuse axonal injury (DAI) is a type of traumatic brain injury. It happens when the brain suddenly and swiftly shifts inside the skull while an injury is happening. The axons (long connecting fibers) in the brain are sheared when the brain smacks against the skull and bounces back, accelerating and decelerating rapidly.

DAI commonly damages many parts of the brain, to the extent that DAI patients are typically in a coma state. The main symptom is loss of consciousness, which usually lasts no more than six hours or so. But even if a person comes out of a comatose state, there may be signs of brain damage such as:

This multi-pronged treatment that combines injections of stem cells and chemical formulas with nerve stimulation is brand new and already attracting controversy. Some of the debate has nothing to do with morality or ethics. One question raised was: How do you sign up a study participant who has been pronounced legally dead? (Most U.S. state laws define death as the irreversible loss of heart and lung or brain function.)

If the researchers are successful in restoring brainwaves to an inactive mind, will the patients personality and memories be restored intact? Will the individual be in a mental condition comparable to what s/he had before the traumatic brain injury?

Dr. Ed Cooper, an orthopedic surgeon involved in the study, gave zero odds for success because the procedure must act on a functional brain stem which connects most of the motor neurons to the cerebral cortex.

But Ira Pastor, Bioquarks CEO, agreed with his colleague Cooper in principle but gave hope for a positive outcome because there is a small nest of cells that continue to operate in brain-dead patients.

Pastor is nothing but an optimist about restoring brain activity in comatose or brain-damaged patients. I just think its a matter of putting it all together and getting the right people and the right minds on it, he said.

Dr. Charles Cox, a pediatric surgeon at the University of Texas Health Science Center at Houston who has researched the kind of stem cells used in the Bioquark trial, echoed Dr. Coopers reservations:

I think [reviving someone] would technically be a miracle. I think the pope would technically call that a miracle.

See original here:
Reverse Brain Death with Stem Cells | The Health Edge

Brain Death Reversed With Stem Cells

Stem cells have the potentialto be used to treat and better understand some of the worldsmost deadly and disabling diseases.

The Big Q: Who is not interested in new ways to apply stem celltherapy?

The Big A:We are and have opened our Tatget 150 clinic in Bangkok,Thailand to apply this growing, life extending science.

We have recently heard about scientists in Philadelphia, PA,USA who have been injecting stem cells directly into the spinalcords of medically brain-dead people in order to revive them.

The idea of bringing people back from the dead is alittle too much for some critics to manage.

In March 2017, researchers at the biotechcompany,Bioquark,gotapproval to begin a clinical trial with 20 test patients to seeif neural brain damage could be reversed.

TheBioquarkwebsitesays the research and development organization is a lifesciences company developing proprietary combinatorial biologicproducts for both the regeneration and repair of human organsand tissues, as well as the reversion of a range of chronicdegenerative diseases.

Integrating regenerative biology, evolutionary genomics, andbio-cybernetics, the futurists are offering death-resistingtreatments: a set of novel bio-products capable of directlyremodeling diseased, damaged, or aged tissues.

These achievements alone sound compelling, Yes?

But, then when adding the potential of restoring brain functionto a lifeless mind and the appeal goes up, way up.

Bioquarkgotthe federal nod t go ahead with their Non-randomized,Open-labeled, Interventional, Single Group, Proof of ConceptStudy With Multi-modality Approach in Cases of Brain Death Dueto Traumatic Brain Injury Having Diffuse Axonal Injury study,slated to begin in July 2018. Youll note theres no mention ofraising the dead at this point.

The study participants will not be injected with stem cells.that is just the 1st step of this experimental treatment. Next,a peptide formula will be injected into the spinal cord. Thisis supposed to help new neurons grow. Finally, a 15-day courseof nerve stimulation and laser therapy will be administered, tostimulate neurons to form connections.

The main diagnostic tool is the electroencephalogram (EEG)which measures brainwaves and records them for future review.EEG results will be used to determine if the therapy is workingor not.

Diffuse axonal injury (DAI) is a type of traumatic braininjury. It happens when the brain suddenly and swiftly shiftsinside the skull while an injury is happening. The axons (longconnecting fibers) in the brain are sheared when the brainsmacks against the skull and bounces back, accelerating anddecelerating rapidly.

DAI commonly damages many parts of the brain, to the extentthat DAI patients are typically in a coma state. The mainsymptom is loss of consciousness, which usually lasts no morethan six hours or so. But even if a person comes out of acomatose state, there may be signs of brain damage such as:

This multi-pronged treatment that combines injections of stemcells and chemical formulas with nerve stimulation is brand newand already attracting controversy.

Some of the debate has nothing to do with morality or ethics,but talk about the way to sign up a study participant who hasbeen pronounced legally dead.

Most US state laws define death as the irreversible loss ofheart and lung or brain function.

The Big Qs 2&3: If the researchers are successful inrestoring brainwaves to an inactive mind, will the patientspersonality and memories be restored intact? Will theindividual be in a mental condition comparable to what theperson had before the traumatic brain injury?

The Big As 2&3:

Dr. Ed Cooper, an orthopedic surgeon involved in the study,gave Zero odds for success because the procedure must act on afunctional brain stem which connects most of the motor neuronsto the cerebral cortex.

But Ira Pastor, Bioquarks CEO, agreed with his colleague, Dr.Cooper in principle but gave hope for a positive outcomebecause there is a small nest of cells that continue tooperate in brain-dead patients.

Dr. Pastor is an optimist about restoring brain activity incomatose or brain-damaged patients. I just think its a matterof putting it all together and getting the right people and theright minds on it, he said.

Dr. Charles Cox, a pediatric surgeon at the University of TexasHealth Science Center atHouston who has researched the kind of stem cells used in theBioquark trial, echoed Dr. Coopers reservations: I thinkreviving someone would technically be a miracle. I think thePope would technically call that a miracle.

Eat healthy, Be healthy, Live lively

brain, cells, dead,injury, loss,miracle, neurons, patients, Pope,restoring, reversed, stem,study

Paul A. Ebeling, polymath, excels in diverse fields ofknowledge. Pattern Recognition Analyst in Equities,Commodities and Foreign Exchange and author of The RedRoadmasters Technical Report on the US Major MarketIndices, a highly regarded, weekly financial marketletter, he is also a philosopher, issuing insights on awide range of subjects to a following of over 250,000cohorts. An international audience of opinion makers,business leaders, and global organizations recognizesEbeling as an expert.

See the rest here:
Brain Death Reversed with Stem Cells - Emex Investment

For much of his professional golf career Nicklaus has had aggravating back pain that he describes as an eight or nine out of 10 on the pain scale. While most golfers live with some degree of back pain Nicklaus said his was particularly debilitating. Despite trying therapies ranging from cortisone shots to a back operation the pain persisted. At the time he flew to Munich, Nicklaus was willing to try anything, even an, as of yet, unproven treatment.

If you don't know much about Jack Nicklaus, you can be certain your parents or grandparents do. He is one of the true sports legends of the United States. With 120 professional tournament victories and a record 18 major-championship titles, he is one of 16 individuals in history to receive both the Presidential Medal of Freedom and Congressional Gold Medal for his outstanding achievements in sports and philanthropy.

Nicklaus said he has taken roughly 10 million swings with a golf club, but when you hear his backstory, it is a wonder his career ever happened. Even before he became a professional, Nicklaus was having severe enough back pain to warrant nine cortisone injections into his back. (These are done to insert medication between the joints to relieve inflammation and pain). He was only 19 years old at the time. While they worked for a short time, Nicklaus played with significant pain for parts of his career. At the age of 64, he underwent a minimally invasive spine operation to relieve the pressure on his spinal nerve roots, which provided some relief for much of the last 14 years, but not nearly enough. Even basic chip shots and putts were too painful.

It was at a birthday party in December of 2015 when Nicklaus first met German stem cell pioneer Dr. Eckhard Alt. Intrigued by what Alt told him about this experimental therapy, 78 year old Nicklaus once again became a student, reading up on Eckhard, the clinic and the possibilities of stem cells. Within a couple of months, he was convinced adipose stem cells, found in abdominal fat, may be something that could finally provide lasting relief for his aching back.

Go here to see the original:
Jack Nicklaus' secret stem cell therapy - CNN

Select a Treatment Addictions Alternative Adult Growth Hormone Deficiency AGHD Bio-identical Hormone Replacement (BHRT) Chelation Therapy Dr Rath Vitamins Holistic Medicine Hormone Replacement Therapies Human Growth Hormone Replacement IV therapies Medical Weight Loss Megadose Intravenous Vitamin C Micro biota strengthening Myers Cocktail Neural Therapy Orthomolecular Medicine Pulsed Electromagnetic Fields PEMF diagnostic Stem Cells Transplant The Simeon Diet Anti-Aging Botox Facial Rejuvenation Fillers P-Shot Platelet-Rich Plasma (PRP) PRP with Dermapen PRP without Dermapen Ayurveda Bariatric or Weight Loss Surgery Gastric Band Gastric Bypass or Roux-en-Y Gastric Plication Gastric Sleeve or Sleeve Gastrectomy Metabolic Surgery for Type 2 Diabetes Cardiology Colorectal Surgery & Proctology Haemorrhoid Surgery with PPH Laparascopic colectomy for diverticular disease Surgical management of constipation Cosmetic Surgery for the Body Arm lift or Brachioplasty Brazilian Butt Lift Breast Augmentation or Breast Implants Breast Lift Breast Reconstruction Post Mastectomy Breast Reduction Buttock Augmentation Buttock Implants Buttock Lift or Gluteoplasty Coolsculpting Gynecomastia Surgery or Male Breast Reduction Lipo-Injection Liposuction or Liposculpture or Lipectomy Lower Body List Mini Tummy Tuck or Partial Abdominioplasty Minor Surgeries Mommy Makeover Nipple Reduction or Inversion Pectoral Liposuction Scar Revision Thigh Lift or Thighplasty Tummy Tuck or Abdominoplasty Upper Body Lift Cosmetic Surgery for the Face Bichat Bags or Bichectomy Blepharoplasty or Eyelid Surgery Cheek Implants Chin Implants Chin Liposuction Ear Surgery or Otoplasty Eyelid Lift Face lift or Rhytidectomy Facial Implants Facial Trauma & Facial Irregularities Forehead Lift or Brow Lift or Browplasty Hair Transplant Lip Augmentation Neck Lift Neck Sculpting Rhinoplasty or Nose Reshaping Dental Procedures All on 4 All on 5 All on 6 All on 8 Bone Graft Bridges Cosmetic Dentistry Crowns Dental Cleaning Dental Implants Dental Surgery Endodontics Fillings Full mouth restoration Inlays & onlays Oral & Maxilofacial Surgery Orthodontics Orthognatic (Jaw) Surgery Periodontics Prosthodontics Removable Dentures Root Canal Sinus Lift Smile Design TMD Temporomandibular Joint Disorders Veneers Whitening Wisdom teeth extraction Dermatology Botox CO2 laser skin resurfacing Cryosurgery Fillers Lesions/Moles Mohs Surgery Skin Cancer Screening SPA services Diabetes Ear, Nose & Throat BAHA Surgery Balloon Sinuplasty Base of Cranium surgery Cancer of Head & Neck Coblation or Reduction of Turbinates Cochlear Implant Surgery Ear Disease Treatment Early detection of Hearing Loss in Newborn babies Facial Paralysis Management Head Surgery (minimally invasive) Hearing Aids Hearing Loss Diagnosis, Management & Treatment Loss of Smell Valuation Middle Ear implants (Soundbridge, Bonebridge) Middle Ear Surgery Nasal Surgery Neck Surgery (minimally invasive) Polysomnography Septoplasty Sinus Surgery (Functional Endoscopic) Sleep Studies Surgery of the Cerebellopontine Angle Swallowing Disorders Tonsillectomy Turbinoplasty Vertigo Treatment or Surgery Voice Disorders Endocrinology Executive Health Checks Eye Surgery Cataract Surgery Diabetic Eye Disease Treatments Glaucoma Surgery Intravitreal injections LASEK Laser surgery without flap LASIK PRK Pterygium & External Diseases Surgery Refractive & Laser Eye Surgery Retinal & Vitreous Surgery Fertility Treatments Artificial Insemination Gamete Transfer IVF In Vitreo Fertilisation Gastroenterology Anorectal Manometry & Biofeedback Anti-GERD Endoscopic Technique Capsule Endoscopy Colonoscopy Conventional or Stapled (PPH) hemorrhoidectomy Detection of Premalignant Lesions Diagnostic & Therapeutic Endoscopy Digestive Endoscopy Digestive Surgery Diverticular Disease Surgery Endoscopic oesophageal or pyloric or colon dilation Endoscopic Surgery Esophageal Manometry for Gastroesophageal Reflux Disease (GERD) Gastroenterology Consultation Gastroscopy Infrared Coagulation (IRC) for haemorrhoids Percutaneous Endoscopic Gastrostomy (PEG) Polipectomy Removal of Polyps Secca Technique for fecal incontinence Stretta Treatment of Digestive Diseases Video Colonoscopy Video Gastroscopy Video Intestinoscopy General Surgery Abdominal Organs Surgery Abdominal Wall Closure Abdomino-peineal resection Appendectomy Cavity Washing / Cleansing Cholecystectomy - Gall Bladder Colon Cancer Surgery Digestive Surgery & Obesity Consultation Drainage & Debridement Duodenal Switch EndoCapsule Mucosal Dissection (ESD) Endoscopic Retrograde cholangiopancreatography (ERCP) Exploratory Laparotomy Gall stones or Gall Bladder polyps Surgery Gastroesophageal reflux or Acalasia Surgery Hemorrhoidectomy Hernioplasty of incisional hernia Hernioplasty of umbilical hernia Hiatal Hernia Surgery Inguinal Hernia Surgery Intestinal resection Laparascopic heller Laparoscopic Appendectomy Laparoscopic Cholecystectomy - Gall Bladder Removal Laparoscopic nissen Laparoscopic repair of incisional hernia Laparoscopic splenectomy Left hemicolectomy Low Anterior Resection Rectal Cancer Surgery Right Hemicolectomy Sphincterotomy Stomach cancer surgery Gynecology Annual Well-Woman Check Climateric Consulting Colposcopy Cryotherapy Endometriosis Family planning consultation General gynaecological surgery Hysterectomy LEEP or cone Ovarian Cysts Pelvic Pain Vaginal Surgery Hair Loss Treatment Infertility Treatments Nephrology Neurology Obstetrics Caesarian Births Prenatal Checks Vaginal Births Oncology Oriental Medicine Acupuncture Cupping Five Element Theory Gua Sha Moxibostion Oriental Body Therapy Qi gong Thai Massage Traditional Chinese Medicine Tui Na Orthopedics for Hands Carpal Tunnel Release Ganglion (Cyst) of the Wrist Hand Procedures Orthopedics for Hips Hip Decompression Hip Resurfacing Total Hip Replacement Orthopedics for Knees Anterior Cruciate Ligament (ACL) injury Arthritis of the Knee Knee Arthroscopy Knee Injuries Meniscal Tears Partial & Total Knee Replacements Posterior Cruciate Ligament Injury Runner's Knee Surgical Treatment of Osteoarthritis Orthopedics for Shoulders Arthritis of the Shoulder Biceps Tendinitis Clavicle Fracture (Broken Collarbone) Rotator Cuff Tears Shoulder Arthroscopy Shoulder Impingement Shoulder Instability Shoulder Joint Replacement Physical Therapy Podiatry Reproductive Medicine Retirement Alzheimers Care Assisted living Independent Living Memory Support Skilled Nursing Spinal Surgery Spine Surgery Spinal Decompression Sports Injuries Stem Cell Aging Alzheimer's Disease Cardiovascular Disease Diabetes Erectile Dysfunction Knee Injury Lupus Myocardial Infarction Neuropathy Osteoarthritis Osteoporosis Parkinson's Disease Thoracic Surgery Urogynecology & Urodynamics Computerised Urodynamics Electrostimulation of Pelvic Floor Prolapse of Pelvic Floor Reconstructive Vaginal Plasty with nets Reeducation of Pelvic Floor Suburetales Slings Training Pelvic Floor with Vaginal Cones Urinary Incontinence Urodynamics Clinic Vaginal Reconstruction Surgery with nets Urology Vascular Surgery CCSVI Liberation Therapy for Multiple Sclerosis Wellness & Spa Aesthetics Balneotherapy Biocelular Regenerator Body Wraps Clay Therapy Colonics Dentistry Detoxification Programs Electotherapy equipment Facials Fitness therapies Holistics Programs Hot & Cold Compresses Hot Springs Hydrotherapy Intravenous Vitamin Therapy Laser Life Coaching Magnotherapy Massage Meditation Nutrition Pain Management Physiatry Physiotherapy Pilates Platelet Rich Plasma Therapy (PRP) Pressotherapy Radiofrequency Radiology Rehabilitation Addictions Anxiety Bi-polar Depression Detox Dual Diagnosis Personality Disorders Schizophrenia Reiki Rejuvenation Programs Shirodhara Shock Waves Spa program Stress Management Therapeutic Ultrasound Watsu Weight management Yoga classes Yoga Iboga Retreats Yoga Retreats Yoga Teacher Training Yoga Training

Category Total Care Contract Nursing Care Financing Options Medical Tour Agents Medical Travel Insurance Travel Airlines Aparthotels Bed & Breakfast Car Rentals or Private Driver Hostels Hotels Recovery Centers Treatment Dentists Doctors Alternative Therapies Bariatric Surgery Cardiology Cosmetic Surgery Dermatology Ear, Nose & Throat Endocrinology Fertility Gastroenterology General Surgery Gynecology & Obstetrics Nephrology Neurology Oncology Ophthalmology Orthopedics Proctology Stem Cell Urology Hospitals & Clinics Rehabilitation Addictions Physical Therapy Retirement Wellness & Spa Yoga Trips All Inclusive Hotels Boutique Hotels Local Airlines Tour Operators

Location Alajuela Arenal Atenas El Cacao San Ramn Cartago Cartago Guanacaste Huacas Liberia Nosara Playa Conchal Punta Islita Tamarindo Heredia San Isidro Limn Puntarenas Dominical Drake Bay Esterillos Golfito Jaco Manuel Antonio Puerto Jimnez Quepos Tambor Tarcoles Uvita San Jos Curridabat Escaz Pavas Rohrmoser Santa Ana Tibs

Search

Read more:
Stem Cell Costa Rica

Stem cells are the bodys raw material cells from which all other cells with specialized functions are generated. Stem Cells are widely used around the world to treat many diseases. What makes stem cell treatment in Costa different from treatment in other places?

Stem cell therapy in Costa Rica is an amazing modern medical advancement that goes straight to the source of the problem to treat various disorders like; Alzheimers disease, atherosclerosis, diabetes, Parkinsons disease, rheumatoid arthritis,acute lung injuryas well as many other diseases. Specialized clinics like, the Stem Cells Transplant Institute in Costa Rica, offer customized stem cells therapies.

Stem cell treatments in Costa Rica have been available to patients for several years with positive. However, it was not until recently that stem cell treatments were legalized. The process for approval was slow causing some stem clinics close. Today stem cells treatment in Costa Rica is legally approved and endorsed by the government making it one of the leading countries worldwide for treatment and research.

The Stem Cells Transplant Institute in Costa Rica, under the direction of Dr. Leslie Mesn, is a pioneer in the use of stem cell therapies. Patients of the clinic should feel confident about the quality of our therapies.

At the Stem Cells Transplant Institute in Costa Rica, we use adult autologous stem cells. Stem cells are harvested from a sample of your own adipose tissue or bone marrow. Then, after the cells have been separated and activated, they are reinjected intravenously or directly into the zone required, depending on the disease. Protocols are strictly enforced and treatment is very safe making Costa Rica and ideal choice for stem cell therapy. Some clinics in other countries practice allogeneic transplants, meaning the patient receives stem cells from a donor, either related or unrelated to the patient. In a few cases we have even learned about clinics using stem cells derived from animals. In an allogeneic transplant, because the cells do not come from the patient, there is a higher risk of the patient rejecting the cells. In Costa Rica the stem cells are obtained from your own tissue so the possibility of rejection is almost zero. It is important for you to speak with your physician about the possible risks as well as the benefits of stem cell based products.

Another advantage of stem cell treatment in Costa Rica is the lower cost of therapy when compared with other countries like the United States or Europe. Cost does not always equal quality. The World Health Organization has ranked Costa Rica as one of the top three healthcare systems in Latin America, and Costa Rica consistently ranks higher in healthcare than many industrialized countries including Canada and the United States. Price does not reflect safety or efficacy. Why should you pay more? Stem cell treatment in Costa Rica is safe, effective and price-friendly. Dr. Leslie Mesn, Chief Medical Officer of the Stem Cells Transplant Institute in Costa Rica is an expert in the field of stem cell therapy and continues to stay current by attending continuous education courses in the United States and Latin America. Dr. Mesen is a dedicated professional, aware that every patient is unique. He understands the limitations of traditional medicine and will help you achieve the desired outcome through a minimally invasive stem cell treatment in Costa Rica.

The Stem Cells Transplant Institute in Costa Rica believes in the importance of its patients. Are you aware how important you are? Your health and security should be your top priority when choosing the correct place to receive your stem cell treatment. Costa Rica has one of the best stem cell clinics in the world as well one of the best climates in the world. Make your trip more than a medical visit by enjoying the climate and natural beauty of Costa Rica. Costa Rica is a great medical destination. We are sure the more you learn about this incredible destination, the more you will want to come and visit.

Stem Cell Treatment in Costa Rica is growing fast. Costa Rica is also a point of meeting of important health scientist and professionals, this past March 6th and 7th we had de I Regenerative Medicine International Conference Costa Rica 2017, hold at the Tennis Club in San Jos, with the participation of relevant speakers like Dr. Arnold Caplan, Barbara Krutchkoff, PhD, Graham Parker, PhD and many others. Stem Treatment in Costa Rica is up-to-date with latest advances and techniques applied all over the world.

In conclusion, Stem Cells Therapies in Costa have state-to-the-art technologies and human resources. Costa Rica ranks as one of the best healthcare systems in the World. The therapies are based on your own stem cells, with the highest security standards. Costa Rica plays an important role in Stem cells investigations and applications. And finally, but very important Costa Rica is just an amazing place you have to visit.Contact us.

Go here to read the rest:
Stem Cells Therapy in Costa Rica - Stem Cells Transplant ...

Image:CIMA Hospital in Escaz

Global Stem Cells Group announces plans to expand its Stem Cell Center Network to include a new stem cell treatment center in Escaz, Costa Rica.

MIAMI, Dec. 21, 2017Global Stem Cells Group (GSCG), a world leader in stem cell and regenerative medicine, has announced the opening of a new stem cell center in its Stem Cell Center Network in Escaz, Costa Rica. The new center will focus on treating patients who suffer from regenerative illnesses.

The new center, located at the CIMA Hospital in Escaz, will be headed by Leslie Mesen, M.D., a specialist in anti-aging medicine.

The new center is part of Global Stem Cells Groups worldwide expansion of its clinical presence, partnering with qualified physicians experienced in stem cell therapies to open new clinics and utilize GSCG stem cell products and protocols inpatient treatments. GSCG has established similar alliances in 33 cities worldwide.

The new centers location at the CIMA Hospital in Escaz offers a safe and luxurious venue for patients traveling from the U.S. and other countries for treatment.

Mesen studied medicine at the Ibero-American University (UNIBE) in San Jos, Costa Rica. He leads numerous regenerative medicine courses in the United States and throughout Latin America. He is board certified in anti-aging and regenerative medicine byThe American Academy of Anti-Aging Medicine.

Mesen has served as chief medical officer of three highly-recognized anti-aging institutes, including the Costagenics Age Management program (2007-2010), Anti-Aging Institute of the Americas (2010-2013) and the Anti-Aging and Wellness Clinic (2014-present).

The new center in Escaz is equipped with the latest, cutting-edge regenerative medicine technology. Mesen was trained in Global Stem Cells Group facilities in the U.S.

This new center, headed by Dr. Mesen, is a perfect reflection of Global Stem Cells Groups commitment to meet the growing needs of clients and patients, says GSCG founder and CEO Benito Novas. Together with Dr. Mesen, we will continue to provide the latest medical technology and benefits available through our regenerative medicine products and protocols.

Global Stem Cells Group hopes to approve five more franchises in early 2108. If you are a pysician interested in learning more about joining the worldslargest regenerative medicine practitioner network please contact us http://www.stemcellcenter.net

GSCG provides stem cell treatments for a variety of conditions, diseases, and aesthetic treatments at facilities worldwide. The new facility will have an international staff experienced in administering the leading cellular therapies available.

Global Stem Cells Groups Escaz clinic is certified for the medical tourism market, and staff physicians are board-certified or board-eligible. GSCG clinics provide services in more than 10 specialties, attracting patients from the United States and around the world.

GSCG is committed to providing the highest standards of services and technology, expert and compassionate care, and a philosophy of exceeding the expectations of their international patients.

To learn more about Global Stem Cells Group, visit the GSCG website, email info@stemcellsgroup.com, or call +1305 560 533

About Global Stem Cells Group:

Global Stem Cells Group (GSCG) is a worldwide network that combines seven major medical corporations, each focused on furthering scientific and technological advancements to lead cutting-edge stem cell development, treatments, and training. The united efforts of GSCGs affiliate companies provide medical practitioners with a one-stop hub for stem cell solutions that adhere to the highest medical standards.

Global Stem Cell Groups aim is to be the largest recognized stem cell and regenerative medicine network in the world.

Escaz, Costa Rica.

Go here to read the rest:
Escaz, Costa Rica: Stem Cell Network to expand

Directions to CHDD from Main Information Desk at UWMCThe Patient Information Desk on the main (3rd Floor) of UWMC has detailed directions and a map to CHDD and may be able to provide an escort. From the Information Desk take the Pacific Elevators to the 1st Floor of the hospital. Walk through the Plaza Caf and exit the back glass doors of the hospital. CHDD is the four story brick building directly across the street. Check in at the reception desk on the main (2nd Floor) of CHDD.

Access the lot from 15th Avenue N.E. Stop at gate house 6 to obtain a parking permit.

Look for CHDD- designated or UWMC disability parking stalls. Walk out of S1 at the east end and enter CHDD Clinic building. Patients can be dropped off at the CHDD entrance from which vehicles can return to S1 for parking. A cash payment of $15.00 is required upon entry. Please leave the permit on your dashboard. A partial discount voucher will be given at appointment check-in for patients or family members.

CHDD Parking Brochure (PDF)

Disability ParkingFor All CHDD patients and families with mobility parking needs, the closest parking is in the S1 Garage. Please request a disability placard at the gate house. A cash payment of $15.00 is required upon entry. Please leave the permit on your dashboard. A partial discount voucher will be given at appointment check-in for patients or family members. Valet parking is available at the main entrance of the Medical Center; wheelchairs and escort services are available from the Information Desk.

Valet ParkingValet parking service for patients and their visitors is located in front of the Medical Center, near the main entrance. Allow extra time if you choose to use valet parking.

From valet service, walk east to the main entrance of UWMC. The Information Desk has detailed directions and a map to CHDD and may be able to provide an escort.Triangle Parking GarageThe Triangle Parking Garage is located on N.E. Pacific Place, across the street from UW Medical Center. From Montlake Blvd., turn left onto N.E. Pacific Street and right onto N.E. Pacific Place. The Triangle Garage has a height restriction of 6 8. Allow extra time if you choose to use the Triangle Parking Garage.From the Triangle Garage, take the pedestrian tunnel to the front entrance of the UWMC. The Information Desk has detailed directions and a map to CHDD and may be able to provide an escort.

Surgery Pavilion Parking GarageThe Surgery Pavilion Parking Garage is accessed off of N.E. Pacific Street next to the Emergency Room entrance. The Surgery Pavilion has a height restriction of 9 6 on Level P1. Levels P2 & P3 (2nd & 3rd floor) have a height restriction of 6 7. Allow extra time if you choose to use the Surgery Pavilion Parking Garage.

From the Surgery Pavilion Parking Garage, take the elevator to the third floor. Walk across the pedestrian overpass to the main hospital building lobby. The Information Desk has detailed directions and a map to CHDD and may be able to provide an escort.Payment Rates for parking in S-1, Valet, Triangle, Surgery Pavilion:Patients parking in S-1 will need to pay $15 up front which will be partially reimbursed with validation upon exiting the parking lot (see rates for parking in link above). Credit/Debit cards will be reimbursed on the card, while patients paying cash will be given a cash reimbursement.

Getting to UW Medical Center

Read the original here:
Genetic Medicine Clinic at UW Medical Center | UW Medicine