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Biomedical Sciences Graduate Program | Biotechnology

February 20th, 2019 12:42 am

Research inBiotechnology at UVA brings togetherresearchers from all biomedical, engineering, and chemical sciences at UVA to promote state-of-the-art collaborative science. From this innovative science comes conceptual breakthroughs and new products.In 2000, we established a Biotechnology Training Program (BTP)at UVAwith the goal of providing fertile ground for the development of future leaders in science and technology. It is one of only 19 BTPs nationwide. Our graduates are scientific leaders at major biotechnology companies, federal agencies, and foundations, and lead independent research labs at universities, or are postdoctoral scientists at institutions nationwide.

The BTP offers many enhancements. The 2 3 month company externship training is transformative. Some students alter career plans towards academia or industrial research. Others affirm prior career directions or receive unexpected offers of employment. All make important contributions, some publish articles, and invariably the collaboration enhances thesis projects. Venues are worldwide, from Boston to San Francisco to Australia, England, Holland, Finland, Germany, Spain and Sweden.

We also offer company tours including Merck, Pfizer, BD; panel discussions with industrial leaders including BTP alumni; as well as seminars and biannual symposia that gather recognized innovators under the umbrella of a broad scientific theme.

Our outstanding mentorsfrom across the sciences at UVA are award-winningleaders in their fields, with success in nurturing the best from our students. Many hold patents, and several have started companies. This is an exciting time for our students to be at the frontlines of science and technology.

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Longevity – SNPedia

February 18th, 2019 9:45 pm

Research on longevity, which can also be thought of as maximal lifespan, is more popularly associated with extending human life than with the more strict connotation of life expectancy (more at Wikipedia). Heredity and other factors (such as birth order and age of the mother at the time of the person's birth) influence longevity. [1]

There are at least 3 potentially overlapping classes of SNPs (or other genetic polymorphisms) that can be considered to affect longevity. First, many SNPs may influence susceptibility to diseases that shorten longevity; these can be found in SNPedia associated with those diseases, and related information is summarized on the heritability page. Second, some SNPs are being discovered based on their prevalence in people who live beyond average human lifespan; these SNPs may enhance longevity. Third, certain SNPs may be to able to affect longevity only in certain environmental contexts, for example SNPs that shorten or lengthen longevity only if an individual with a given genotype is also exposed to certain diets or toxins (such as cigarette smoke).

SNPs from the latter two categories include:

A 2017 GWAS analysis of parental longevity in 300,000 UK Biobank participants of European descent found 10+ SNPs to be associated with combined mothers' and fathers' attained age (and a few others just with paternal or maternal age); these 10+ SNPs and the longevity-associated allele were [PMID 29227965]:

Overall, it's useful to realize that SNPs are likely to influence your risk of dying from 9 of the top 10 causes of death (in developed countries), as noted below (based on 2000 US data):

10.1126/science.1190532 identified 150 snps however numerous questions about the plausibility of the results, led to it's eventual retraction.

http://genomics.senescence.info/download.html

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Can Stem Cells Stop Aging? – Medical News Bulletin …

February 18th, 2019 9:44 pm

Aging is a natural process that is the cumulative effect of genetic and environmental damage to our bodies and DNA. Stem cells found within the body help to combat the effects of aging. Researchers in the US have summarized the research to date concerning how stem cells and anti-aging genes impact the process of aging.

Aging is the unavoidable consequence of living, which may bring a host of health problems. Loss of hearing, vision, muscle strength, bone mass, immunity, cognition, and metabolism are just a few of the issues aging causes. Cumulatively, these health issues impact the society, the economy, and the health care system. Although we cope with these issues through shared programs such as senior housing, retirement savings, and Medicare, they do not cure but merely treat the health problems associated with aging.

Aging is a natural progressive development that is controlled by genetic and environmental factors. These factors negatively or positively affect our bodies to increase or decrease the aging process within our bodies. The accumulation of these factors will ultimately affect the stem cells within our bodies, which can be considered the essential building blocks of our bodies. Stem cells do not typically do work in our bodies, unlike muscle cells that are used for running or neurons within our brain for thinking. Instead, stem cells have the special ability to create copies of themselves and transform into other types of cellssuch as muscle cells or neurons which is the basis of body regeneration.

Stem cells could be considered the key to regulating our aging. Since aging is the natural deterioration of our bodies, stem cells help regenerate our bodies by replacing old cells that are too deteriorated to work or damaged beyond self-help. This is seen most prominently within other animals such as those belonging to thePlanaria genus, which can regenerate their entire bodies in five days, and Hydra, which can also regenerate their entire bodies in seven to ten days. Salamanders can also regenerate their limbs within just a few days.

Although humans do not share the same extent of regeneration, we do have the capacity of regenerating over 2/3 of our livers as well as the entire tips of our fingers at a young age. However, our regeneration is more apparent in healing our bodies from the daily traumas we endure such as environmental pollutants, smoking, drinking, stress, social burden, and depression. A recent review in the journal Stem Cell Research and Therapy summarizes what we know so far about stem cells and aging.

In conjunction with stem cells, genetics play a pivotal role in determining how fast we age. Klotho, named after the Greek goddess which controls the thread of life, is one of the most well-studied anti-aging genes. In genetic studies, turning Klotho on increases the lifespan of mice, while turning Klotho off results in premature aging. Researchers have shown Klotho controls many elements of aging such tissue oxidation, insulin levels, and stem cell regeneration.

Telomere length has been shown to be highly associated with body age. Telomeres are the end-caps of DNA that protect them from being damaged. The longer your telomeres are, the younger your body is. Normally, we are all born with long telomeres, however, as we age our telomeres begin to shorten. Indeed, telomere shortening has been known to be a cause of stem cell senescence (deactivation) and subsequent death.

To combat telomere shortening, our bodies employ an enzyme called telomerase to maintain telomere length as we age. However, telomerase activity also diminishes with age which limits its anti-aging capabilities. Interestingly, calorie restriction has been shown increase telomerase activity and maintain telomere length. Lowering calorie intake by 30% increases lifespan by 30%. Calorie restriction in animal models have shown to have beneficial effects on counteracting oxidation, inflammation, detoxification, telomerase activity, and DNA repair. This phenomenon has been consistent across all animals tested of all complexity suggesting a fundamental link between diet and aging. For ethical reasons, this has never been proven in humans and is not condoned by physicians.

The goal of many current anti-aging treatments is to increase the health and population of stem cells within the body to better counteract the effects of aging through regeneration. One type of stem cell that is of keen interest to researchers and pharmaceutical companies are mesenchymal stem cells (MSC). These stem cells have been shown to be a core factor in skin, muscle, cartilage, and bone regeneration. Normally, MSC is found in the bone marrow. When the body is injured (e.g. skin cut), cytokines, which are chemical signals used by the body to communicate, are released to activate MSC and travel to the injured area for repair.

However, as we age the number of mesenchymal stem cells within our bone marrow will deplete which slows down our regeneration causing us to age. This is most apparent within our skin which deteriorates over time causing loss of elasticity, sagging, and wrinkling. Pharmaceutical companies are interested in harvesting certain growth factors, which are found naturally within our body, to supplement into skin care products. This will hopefully cause the mesenchymal stem cell population within the skin to multiply which will increase our bodys natural skin regeneration.

Aging is a natural process that is the cumulative effect of genetic and environmental damage to our bodys and DNA. Stem cells found naturally within our body help to combat the effects of aging, but degrade over time due to factors such as telomerase decline. Though researchers and pharmaceuticals have shown ways to extend lifespans through genetic and diet alterations, the goal of halting aging altogether seems distant. However, a new wave of anti-aging products, medical advancements, and a better understanding of diet may be able to slow down the aging process and give us more exciting and youthful years.

Written byAaron Kwong, MSc

References:

(1) Ullah, M. & Sun, Z. Stem cells and anti-aging genes: double-edged sworddo the same job of life extension. Stem Cell Res. Ther.9, 3 (2018).(2) Shieh, S.-J. & Cheng, T.-C. Regeneration and repair of human digits and limbs: fact and fiction. Regen. (Oxford, England)2, 14968 (2015).(3) Ogoke, O., Oluwole, J. & Parashurama, N. Bioengineering considerations in liver regenerative medicine. J. Biol. Eng.11, 46 (2017).(4) Heilbronn, L. K. & Ravussin, E. Calorie restriction and aging: review of the literature and implications for studies in humans 1 3. (2003).

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Olivia Colman’s heartfelt appeal for stem cell donors …

February 18th, 2019 9:44 pm

BAFTA winner Olivia Colman has made a heartfelt appeal for people to donate stem cells after losing her school friend to blood cancer.

The Favourite actress revealed how a transplant gave classmate Pip hope in the darkness.

In a video for the charity Anthony Nolan, the star describes how her friend, who was diagnosed with leukaemia at the age of 31, didnt make it.

Colman urges the public to sign up to the charitys stem cell register, which she and husband Ed Sinclair joined in 2008, so that others have a chance of living. In the film, she says: Sadly my friend Pip didnt make it, but together we can make sure more people like Pip do make it. We want more people on the register. Its just a little swab of the mouth Without you there is no cure.

Pips only chance of survival had been a donor who could provide a perfect match, according to Colman. Soon a donor was found in Australia. Anthony Nolan did an amazing thing, Colman said. She became patron of Anthony Nolan in July last year.

About 2,000 people in the UK need a stem cell transplant every year. Donations from young men and people with black, Asian and ethnic minority backgrounds are needed in particular.

Anthony Nolans chief executive Henny Braund said: It is wonderful to have Olivias support and I am grateful to her for sharing this heartfelt story. This will help us continue to give hope to thousands of people every year.

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Regenerative Medicine | Swedish Medical Center Seattle and …

February 18th, 2019 9:42 pm

Regenerative medicine (platelet rich plasma, stem cell treatment and tenex) is a non-surgical and natural treatment to stimulate and enhance healing of injuries, such as osteoarthritis, tendinitis, plantar fasciitis, and degenerative musculoskeletal diseases.

Most simply defined, PRP is a platelet count above normal. Platelets are your bodys natural healing particles. When you get an injury, platelets in your blood go to the area of injury. Your platelets release growth factors (programming signals) that tell your brain you have an injury and what type of stem cells to send to the area so you get an appropriate healing response. Once concentrated out of a larger volume of blood, PRP can be injected under ultrasound guidance into the injured area to stimulate and enhance healing. PRP has been shown to be beneficial on conditions such as tendinitis/tendinosis, tendon tears, ligament sprains/tears, muscle tears, and osteoarthritis/ joint pain. PRP can also be used in the spine, where the injections are placed using x-ray guidance after careful confirmation that those structures are indeed the source of pain.

This process involves harvesting your stem cells from your bone marrow in your pelvis and concentrating the stem cells by processing the bone marrow in a specialized centrifuge. After first numbing the area so it isnt painful, a needle is used to withdraw bone marrow from your posterior iliac crest (lower back area). This is the same procedure performed for over 50 years in hematology offices. Special centrifuges are then used to spin the bone marrow and separate out and concentrate the stem cells. The stem cells are then activated with platelet rich plasma (PRP) and injected under ultrasound guidance into damaged tissue or joints. Some of the most common applications of stem cell treatments are for osteoarthritis, avascular necrosis, tendon and ligament sprains/tears, tendinitis/tendinosis labral tears, and muscle tears. Stem cells can also be used in the spine, where the injections are placed using x-ray guidance after careful confirmation that those structures are indeed the source of pain.

Recently, percutaneous ultrasonic tenotomy (UT) has evolved as a potential minimally invasive treatment for tendinopathy. This has been performed at Swedish sports medicine since 2014. It is a novel technique in which phacoemulsification (sound waves) are used to debride (clean up) and aspirate bad tendon tissue through a small incision via a small handpiece. Studies have shown it to be safe and effective at treating tendinopathies in multiple different tendons, including documentation of success in treatment of plantar fasciopathy after previous release. It is most commonly used on Achilles tendinitis, lateral epicondylitis (tennis elbow), medial epicondylitis (golfers elbow), plantar fasciitis/ plantar fascial rupture, patellar tendinitis, quadriceps tendinitis, calcific tendinitis of the shoulder, gluteal tendinitis, and hamstring tendinitis.

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Global Regenerative Medicine Market Analysis & Forecast to …

February 18th, 2019 9:42 pm

NEW YORK, Feb. 14, 2019 /PRNewswire/ -- This report provides a comprehensive overview of the size of the regenerative medicine market, segmentation of the market (stem cells, tissue engineering and CAR-T therapy), key players and the vast potential of therapies that are in clinical trials. Kelly Scientific analysis indicates that the global regenerative medicine market was worth $28 billion in 2018 and will grow to over $81 billion by 2023, with a CAGR of 23.3% between this time frame. Within this market, the stem cell industry will grow significantly at a CAGR of over x% and reach $x billion by 2023. Tissue engineering is forecast to grow at a CAGR of x% to 2023 and potentially reach $x billion. This report describes the evolution of such a huge market in 15 chapters supported by over 350 tables and figures in 700 pages.

Read the full report: https://www.reportlinker.com/p04876076

An overview of regenerative medicine that includes: stem cells, allogenic and autogenic cells, umbilical cord blood banking, tissue engineering and CAR T therapies. Global regenerative medicine market, global breakdown, application breakdown and leading market players Detailed account of the stem cell industry market by geography, indication and company profiles Profiles, marketed/pipeline products, financial analysis and business strategy of the major companies in this space Focus on current trends, business environment, pipeline products, clinical trials, and future market forecast for regenerative medicine Insight into the challenges faced by stakeholders, particularly about the success vs. failure ratios in developing regenerative medicine drugs and therapies. Insight into the biobanking industry globally and its impact on the overall market Description and data for the prevalence of disease types that are addressed by regenerative medicine, stem cells, tissue engineering and CAR-T therapies Financial market forecast through 2023 with CAGR values of all market segments outlined in the objective SWOT analysis of the global market Geographical analysis and challenges within key topographies including the USA, Japan, South Korea, China and Europe

Key Questions Answered

What is the global market for regenerative medicine from 2017 to 2023? What is the global market for regenerative medicine by geography, through 2023? What is the global market for regenerative medicine by indication, through 2023? What is the global market for the stem cell industry from 2017 to 2023? What is the global market for the stem cell industry by geography, through 2023? What is the global market for the stem cell industry by indication, through 2023? What disruptive technology is advancing the overall regenerative medicine market? What are the major company players in the regenerative medicine, stem cells, tissue engineering and CAR-T industries? What types of clinical trials are currently being performed by stakeholders and major players? What are the strengths, weaknesses, opportunities and threats to the market? Which geographic markets are dominating the space? What are the advantages and disadvantages of the allogenic and autologous stem cell industry? What are the main driving forces of this space? What are the main restraints of the regenerative medicine industry as a whole? What is the current environment of the global cord blood bank industry? What are the global access challenges of the regenerative medicine market? What is the space like in Japan, China, South Korea, USA and Europe? What are the main challenges associated with CAR T therapy? When will the first CAR T therapeutics be approved? What are the current regulations for immunotherapies in USA, Europe & Japan? What are the main manufacturing steps in CAR T therapy? What challenges lie ahead for CAR T production?

Countries Covered Global, USA, Europe, UK, Japan, South Korea, Singapore, Asia/Pacific, ROC

Executive Summary

Regenerative medicine's main objective is to heal and replace organs/cells that have been damaged by age, trauma or disease. Congenital defects can also be addressed with regenerative medicine. Therefore, it's market encompasses dermal wounds, cardiovascular disease, specific cancer types and organ replacement. To that end, regenerative medicine is a broader field and manipulates the body's immune system and regeneration potential to achieve its requirement. Financially speaking, investment into this space is dominated by grants, private investors and publicly traded stocks. Looking forward, the regenerative medicine market is promising for a number of robust reasons including:

Increasing number of potentially successful clinical trials Increasing number of mergers and acquisitions High unmet need in many indications Global penetration, especially in Japan will boost the market

Of course restrictions to this market include strict regulations in certain geographies, and also the level of investment required to support R&D, clinical research, trials and commercialization. Reimbursement strategies are also paramount to success of the overall space.

There are over 700 regenerative medicine companies globally at present, that all together have a $x billion market cap. At present the total regenerative medicine market has more than 500 products commercialized. The regenerative medicine market encompasses a number of key technology submarkets including: Cell therapy including stem cells Tissue Engineering Biomaterials BioBanking

Reconstructive surgeries for bones and joints is the mainstay of the regenerative medicine market. Geographically speaking, due to the dominance of the bone and joint reconstruction market, the US has the biggest space. This is followed by Europe. However, due to recent positive legislation in Japan and Europe, the stem cell arena will grow more substantially in these regions over the next five years. By 2023, it is possible that Europe will surpass the US market with respect to stem cell applications, and this will become more likely if the Trump Administration restricts legislation and funding.

Market Applications & Opportunities for Regenerative TherapiesRegenerative medicine, including cellular and gene therapies will have a significant impact on the expenditure of payers, once reimbursement schemes are optimized. To that end a number of conditions that regenerative medicine tackles is synonymous with an aging population such as Cardiovascular diseases & stroke Diabetes Inflammatory and immune diseases Wound healing and soft tissue regeneration Neurodegenerative diseases e.g., ALS, Alzheimer's and Parkinson's Spinal cord injury Musculoskeletal disorders Ocular disease

Global Financial LandscapeThe last few years have been busy for regeneration medicine, cellular therapeutics and the gene therapy industry, with high investment from pharma giants such as Eli Lilly, BMS, Astra Zeneca and Sanofi. Company partnerships were also in motion that included Kite Pharma and Bluebird/Five Prime, Juno and Fate Therapeutics/ Editas Medicine. One of the highlights was the $x billion, four year deal between CRISPR Technologies and Vertex which indicated that gene editing technologies are cutting edge.

Stem Cell Market Analysis & Forecast to 2023Today the stem cell and regenerative medicine industries are interlinked and over the last number of years have grown substantially. Regenerative medicine replaces or regenerates cells, tissues or organs and in order to achieve this uses produces from the pharmaceutical, biologics, medical device and cell therapy spaces. Therefore, cell therapy, and stem cells come under the umbrella market of regenerative medicine. Cell therapy is a platform by which regenerative medicine can achieve its aim and concentrates on using cells as therapeutics to treat disease. In 2018, the global stem cell market was worth $x billion globally, and this is set to rise to $x billion by 2023 with a CAGR of x%.

Tissue Engineering Market Analysis and Forecast to 2023Tissue engineering was the forerunner of the present regenerative medicine market. The area of biomaterials was developed to use cells and biological material and incorporate them into scaffolds and functional tissues. Some of the main applications of tissue engineered products include artificial skin and cartilage and so this area dominates the dermatology, bone and joint submarket. Wound repair is also a significant area for tissue engineering, with products such as Dermagraft in the market.

The global market for tissue engineering was estimated at $x billion in 2018 by Kelly Scientific analysis. It is forecast to grow at a CAGR of x% to 2023 and potentially reach $x billion. Tissue engineering is being driven by the increase in technology of biomaterials, bioscaffolds and bio 3D printing. The rise in the amount of orthopedic transplantations is demanding the market to produce more innovative solutions such as 3D printed organs. In the long term future, Kelly Scientific forecasts the advance of cutting edge 3D bioprinters in this market place

Biobanking Market AnalysisThe biobanking industry is made up of over 500 public and private blood banks globally. These companies and institutions collect, store and distribute adipose tissue, cord blood and birth tissues, musculoskeletal tissues, pericardium, skin, bone, vascular tissue, autologous and allogeneic cells and other biological samples. They operate by charging a collection fee and then a storage fee, which is usually operational for 20 years. Private banking costs between $1,350 to $2,300 as an initial fee, and then between $100 to $175 per annum for storage. Public banking is free, and a number of hybrid models have been introduced in Europe and Asia to date.

CAR-T IndustryThe CAR-T industry is addressing unmet needs in specific relapsed cancers, however does early clinical trial data support a blockbuster status for this upcoming therapy? Some patients do indeed show long term activity and high remission rates, but there is a large proportion of patients with toxicities such as cytokine release syndrome and neurotoxicity. The main players within the CAR-T market are Juno Therapeutics, Kite Pharma, Novartis and Cellectis. The market is moving ahead, backed by years of R&D, from both academia and industry, investors capitol and small clinical studies. From 2017, Kelly Scientific forecasts that CAR T therapy will become more streamlined, with faster manufacturing times as advances in technologies take hold and clinical trials provide more robust evidence that this immunotherapy is robust. These factors, plus strategies to reduce adverse reactions and toxicities and larger players like Novartis taking stage will push CAR T therapy ahead. However, recent deaths in the Juno ROCKET trial are creating questions amongst investors. How will the CAR T space influence the total immunotherapy industry going forward? This comprehensive report scrutinizes the total market and provides cutting-edge insights and analysis.

Read the full report: https://www.reportlinker.com/p04876076

About Reportlinker ReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

__________________________ Contact Clare: clare@reportlinker.com US: (339)-368-6001 Intl: +1 339-368-6001

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Human cloning – Wikipedia

February 18th, 2019 2:41 am

Human cloning is the creation of a genetically identical copy (or clone) of a human. The term is generally used to refer to artificial human cloning, which is the reproduction of human cells and tissue. It does not refer to the natural conception and delivery of identical twins. The possibility of human cloning has raised controversies. These ethical concerns have prompted several nations to pass laws regarding human cloning and its legality.

Two commonly discussed types of theoretical human cloning are: therapeutic cloning and reproductive cloning. Therapeutic cloning would involve cloning cells from a human for use in medicine and transplants, and is an active area of research, but is not in medical practice anywhere in the world, as of April2017[update]. Two common methods of therapeutic cloning that are being researched are somatic-cell nuclear transfer and, more recently, pluripotent stem cell induction. Reproductive cloning would involve making an entire cloned human, instead of just specific cells or tissues.

Although the possibility of cloning humans had been the subject of speculation for much of the 20th century, scientists and policy makers began to take the prospect seriously in the mid-1960s.

Nobel Prize-winning geneticist Joshua Lederberg advocated cloning and genetic engineering in an article in The American Naturalist in 1966 and again, the following year, in The Washington Post.[1] He sparked a debate with conservative bioethicist Leon Kass, who wrote at the time that "the programmed reproduction of man will, in fact, dehumanize him." Another Nobel Laureate, James D. Watson, publicized the potential and the perils of cloning in his Atlantic Monthly essay, "Moving Toward the Clonal Man", in 1971.[2]

With the cloning of a sheep known as Dolly in 1996 by somatic cell nuclear transfer (SCNT), the idea of human cloning became a hot debate topic.[3] Many nations outlawed it, while a few scientists promised to make a clone within the next few years. The first hybrid human clone was created in November 1998, by Advanced Cell Technology. It was created using SCNT - a nucleus was taken from a man's leg cell and inserted into a cow's egg from which the nucleus had been removed, and the hybrid cell was cultured, and developed into an embryo. The embryo was destroyed after 12 days.[4]

In 2004 and 2005, Hwang Woo-suk, a professor at Seoul National University, published two separate articles in the journal Science claiming to have successfully harvested pluripotent, embryonic stem cells from a cloned human blastocyst using somatic-cell nuclear transfer techniques. Hwang claimed to have created eleven different patent-specific stem cell lines. This would have been the first major breakthrough in human cloning.[5] However, in 2006 Science retracted both of his articles on clear evidence that much of his data from the experiments was fabricated.[6]

In January 2008, Dr. Andrew French and Samuel Wood of the biotechnology company Stemagen announced that they successfully created the first five mature human embryos using SCNT. In this case, each embryo was created by taking a nucleus from a skin cell (donated by Wood and a colleague) and inserting it into a human egg from which the nucleus had been removed. The embryos were developed only to the blastocyst stage, at which point they were studied in processes that destroyed them. Members of the lab said that their next set of experiments would aim to generate embryonic stem cell lines; these are the "holy grail" that would be useful for therapeutic or reproductive cloning.[7][8]

In 2011, scientists at the New York Stem Cell Foundation announced that they had succeeded in generating embryonic stem cell lines, but their process involved leaving the oocyte's nucleus in place, resulting in triploid cells, which would not be useful for cloning.[10][11]

In 2013, a group of scientists led by Shoukhrat Mitalipov published the first report of embryonic stem cells created using SCNT. In this experiment, the researchers developed a protocol for using SCNT in human cells, which differs slightly from the one used in other organisms. Four embryonic stem cell lines from human fetal somatic cells were derived from those blastocysts. All four lines were derived using oocytes from the same donor, ensuring that all mitochondrial DNA inherited was identical. A year later, a team led by Robert Lanza at Advanced Cell Technology reported that they had replicated Mitalipov's results and further demonstrated the effectiveness by cloning adult cells using SCNT.[3][12]

In 2018, the first successful cloning of primates using somatic cell nuclear transfer, the same method as Dolly the sheep, with the birth of two live female clones (crab-eating macaques named Zhong Zhong and Hua Hua) was reported.[13][14][15][16][17].

In somatic cell nuclear transfer ("SCNT"), the nucleus of a somatic cell is taken from a donor and transplanted into a host egg cell, which had its own genetic material removed previously, making it an enucleated egg. After the donor somatic cell genetic material is transferred into the host oocyte with a micropipette, the somatic cell genetic material is fused with the egg using an electric current. Once the two cells have fused, the new cell can be permitted to grow in a surrogate or artificially.[18] This is the process that was used to successfully clone Dolly the sheep (see section on History in this article).[3]

Creating induced pluripotent stem cells ("iPSCs") is a long and inefficient process. Pluripotency refers to a stem cell that has the potential to differentiate into any of the three germ layers: endoderm (interior stomach lining, gastrointestinal tract, the lungs), mesoderm (muscle, bone, blood, urogenital), or ectoderm (epidermal tissues and nervous tissue).[19] A specific set of genes, often called "reprogramming factors", are introduced into a specific adult cell type. These factors send signals in the mature cell that cause the cell to become a pluripotent stem cell. This process is highly studied and new techniques are being discovered frequently on how to better this induction process.

Depending on the method used, reprogramming of adult cells into iPSCs for implantation could have severe limitations in humans. If a virus is used as a reprogramming factor for the cell, cancer-causing genes called oncogenes may be activated. These cells would appear as rapidly dividing cancer cells that do not respond to the body's natural cell signaling process. However, in 2008 scientists discovered a technique that could remove the presence of these oncogenes after pluripotency induction, thereby increasing the potential use of iPSC in humans.[20]

Both the processes of SCNT and iPSCs have benefits and deficiencies. Historically, reprogramming methods were better studied than SCNT derived embryonic stem cells (ESCs). However, more recent studies have put more emphasis on developing new procedures for SCNT-ESCs. The major advantage of SCNT over iPSCs at this time is the speed with which cells can be produced. iPSCs derivation takes several months while SCNT would take a much shorter time, which could be important for medical applications. New studies are working to improve the process of iPSC in terms of both speed and efficiency with the discovery of new reprogramming factors in oocytes.[citation needed] Another advantage SCNT could have over iPSCs is its potential to treat mitochondrial disease, as it utilizes a donor oocyte. No other advantages are known at this time in using stem cells derived from one method over stem cells derived from the other.[21]

Work on cloning techniques has advanced our basic understanding of developmental biology in humans. Observing human pluripotent stem cells grown in culture provides great insight into human embryo development, which otherwise cannot be seen. Scientists are now able to better define steps of early human development. Studying signal transduction along with genetic manipulation within the early human embryo has the potential to provide answers to many developmental diseases and defects. Many human-specific signaling pathways have been discovered by studying human embryonic stem cells. Studying developmental pathways in humans has given developmental biologists more evidence toward the hypothesis that developmental pathways are conserved throughout species.[22]

iPSCs and cells created by SCNT are useful for research into the causes of disease, and as model systems used in drug discovery.[23][24]

Cells produced with SCNT, or iPSCs could eventually be used in stem cell therapy,[25] or to create organs to be used in transplantation, known as regenerative medicine. Stem cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplantation is a widely used form of stem cell therapy.[26] No other forms of stem cell therapy are in clinical use at this time. Research is underway to potentially use stem cell therapy to treat heart disease, diabetes, and spinal cord injuries.[27][28] Regenerative medicine is not in clinical practice, but is heavily researched for its potential uses. This type of medicine would allow for autologous transplantation, thus removing the risk of organ transplant rejection by the recipient.[29] For instance, a person with liver disease could potentially have a new liver grown using their same genetic material and transplanted to remove the damaged liver.[30] In current research, human pluripotent stem cells have been promised as a reliable source for generating human neurons, showing the potential for regenerative medicine in brain and neural injuries.[31]

In bioethics, the ethics of cloning refers to a variety of ethical positions regarding the practice and possibilities of cloning, especially human cloning. While many of these views are religious in origin, the questions raised by cloning are faced by secular perspectives as well. Human therapeutic and reproductive cloning are not commercially used; animals are currently cloned in laboratories and in livestock production.

Advocates support development of therapeutic cloning in order to generate tissues and whole organs to treat patients who otherwise cannot obtain transplants,[32] to avoid the need for immunosuppressive drugs,[33] and to stave off the effects of aging.[34] Advocates for reproductive cloning believe that parents who cannot otherwise procreate should have access to the technology.[35]

Opposition to therapeutic cloning mainly centers around the status of embryonic stem cells, which has connections with the abortion debate.[36]

Some opponents of reproductive cloning have concerns that technology is not yet developed enough to be safe - for example, the position of the American Association for the Advancement of Science as of 2014[update],[37] while others emphasize that reproductive cloning could be prone to abuse (leading to the generation of humans whose organs and tissues would be harvested),[38][39] and have concerns about how cloned individuals could integrate with families and with society at large.[40][41]

Religious groups are divided, with some[which?] opposing the technology as usurping God's role in creation and, to the extent embryos are used, destroying a human life; others support therapeutic cloning's potential life-saving benefits.[42][43]

In 2015 it was reported that about 70 countries had banned human cloning.[44]

Human cloning is banned by the Presidential Decree 200/97 of 7 March 1997.[45]

Australia has prohibited human cloning,[46] though as of December2006[update], a bill legalizing therapeutic cloning and the creation of human embryos for stem cell research passed the House of Representatives. Within certain regulatory limits, and subject to the effect of state legislation, therapeutic cloning is now legal in some parts of Australia.[47]

Canadian law prohibits the following: cloning humans, cloning stem cells, growing human embryos for research purposes, and buying or selling of embryos, sperm, eggs or other human reproductive material.[48] It also bans making changes to human DNA that would pass from one generation to the next, including use of animal DNA in humans. Surrogate mothers are legally allowed, as is donation of sperm or eggs for reproductive purposes. Human embryos and stem cells are also permitted to be donated for research.[citation needed]

There have been consistent calls in Canada to ban human reproductive cloning since the 1993 Report of the Royal Commission on New Reproductive Technologies. Polls have indicated that an overwhelming majority of Canadians oppose human reproductive cloning, though the regulation of human cloning continues to be a significant national and international policy issue. The notion of "human dignity" is commonly used to justify cloning laws. The basis for this justification is that reproductive human cloning necessarily infringes notions of human dignity.[49][50][51][52]

Human cloning is prohibited in Article 133 of the Colombian Penal Code.[53]

The European Convention on Human Rights and Biomedicine prohibits human cloning in one of its additional protocols, but this protocol has been ratified only by Greece, Spain and Portugal. The Charter of Fundamental Rights of the European Union explicitly prohibits reproductive human cloning. The charter is legally binding for the institutions of the European Union under the Treaty of Lisbon and for member states of the Union implementing EU law.[54][55]

India does not have specific law regarding cloning but has guidelines prohibiting whole human cloning or reproductive cloning. India allows therapeutic cloning and the use of embryonic stem cells for research proposes.[56][57]

The Federal Assembly of Russia introduced the Federal Law N 54-FZ "On the temporary ban on human cloning" in April 19, 2002. On May 20, 2002 President Vladimir Putin signed this moratorium on the implementation of human cloning. On March 29, 2010 The Federal Assembly introduced second revision of this law without time limit.[58]

Human cloning is explicitly prohibited in Article 24, "Right to Life" of the 2006 Constitution of Serbia.[59]

In terms of section 39A of the Human Tissue Act 65 of 1983,[60] genetic manipulation of gametes or zygotes outside the human body is absolutely prohibited. A zygote is the cell resulting from the fusion of two gametes; thus the fertilised ovum. Section 39A thus prohibits human cloning.[citation needed]

On January 14, 2001 the British government passed The Human Fertilisation and Embryology (Research Purposes) Regulations 2001[61] to amend the Human Fertilisation and Embryology Act 1990 by extending allowable reasons for embryo research to permit research around stem cells and cell nuclear replacement, thus allowing therapeutic cloning. However, on November 15, 2001, a pro-life group won a High Court legal challenge, which struck down the regulation and effectively left all forms of cloning unregulated in the UK. Their hope was that Parliament would fill this gap by passing prohibitive legislation.[62][63] Parliament was quick to pass the Human Reproductive Cloning Act 2001 which explicitly prohibited reproductive cloning. The remaining gap with regard to therapeutic cloning was closed when the appeals courts reversed the previous decision of the High Court.[64]

The first license was granted on August 11, 2004 to researchers at the University of Newcastle to allow them to investigate treatments for diabetes, Parkinson's disease and Alzheimer's disease.[65] The Human Fertilisation and Embryology Act 2008, a major review of fertility legislation, repealed the 2001 Cloning Act by making amendments of similar effect to the 1990 Act. The 2008 Act also allows experiments on hybrid human-animal embryos.[66]

On December 13, 2001, the United Nations General Assembly began elaborating an international convention against the reproductive cloning of humans. A broad coalition of states, including Spain, Italy, the Philippines, the United States, Costa Rica, and the Holy See sought to extend the debate to ban all forms of human cloning, noting that, in their view, therapeutic human cloning violates human dignity. Costa Rica proposed the adoption of an international convention to ban all forms of human cloning. Unable to reach a consensus on a binding convention, in March 2005 a non-binding United Nations Declaration on Human Cloning, calling for the ban of all forms of human cloning contrary to human dignity, was adopted.[67][68]

The Patients First Act of 2017 (HR 2918, 115th Congress) aims to promote stem cell research, using cells that are ethically obtained, that could contribute to a better understanding of diseases and therapies, and promote the derivation of pluripotent stem cell lines without the creation of human embryos.[69]

In 1998, 2001, 2004, 2005, 2007 and 2009, the US Congress voted whether to ban all human cloning, both reproductive and therapeutic (see Stem Cell Research Enhancement Act). Each time, divisions in the Senate, or an eventual veto from the sitting President (President George W. Bush in 2005 and 2007), over therapeutic cloning prevented either competing proposal (a ban on both forms or on reproductive cloning only) from being passed into law. On March 10, 2010 a bill (HR 4808) was introduced with a section banning federal funding for human cloning.[70] Such a law, if passed, would not have prevented research from occurring in private institutions (such as universities) that have both private and federal funding. However, the 2010 law was not passed.

There are currently no federal laws in the United States which ban cloning completely. Fifteen American states (Arkansas, California, Connecticut, Iowa, Indiana, Massachusetts, Maryland, Michigan, North Dakota, New Jersey, Rhode Island, South Dakota, Florida, Georgia, and Virginia) ban reproductive cloning and three states (Arizona, Maryland, and Missouri) prohibit use of public funds for such activities.[71]

Science fiction has used cloning, most commonly and specifically human cloning, due to the fact that it brings up controversial questions of identity.[72][73] Humorous fiction, such as Multiplicity (1996)[74] and the Maxwell Smart feature The Nude Bomb (1980), have featured human cloning.[75] A recurring sub-theme of cloning fiction is the use of clones as a supply of organs for transplantation. Robin Cook's 1997 novel Chromosome 6 and Michael Bay's The Island are examples of this; Chromosome 6 also features genetic manipulation and xenotransplantation.[76] There is also a series named Orphan Black which follows human clones' stories and experiences as they deal with issues and react to being the property of a chain of scientific institutions.

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Cornell Career Services: Veterinary Medicine FAQ

February 18th, 2019 2:41 am

Which college should I enroll in?

A student in any undergraduate college at Cornell may enroll in the courses required for entry into veterinary college. Cornell undergraduate applicants to veterinary school are enrolled primarily in the College of Agriculture and Life Sciences with a few in the College of Arts and Sciences, the College of Engineering, and the College of Human Ecology. The appropriate choice depends largely on your other academic and career interests. Students should consult the University's publications for information about the seven colleges at Cornell, reviewing their requirements, majors, and course descriptions.

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What should I major in?

Veterinary schools do not require or recommend any particular undergraduate major course of study or designated preveterinary program. Cornell does not have a preveterinary major and there is no evidence that admissions committees of veterinary colleges give special consideration to any particular undergraduate education beyond satisfactory completion of the required undergraduate courses; for this reason you are encouraged to pursue your own intellectual interest in an academic major.

For example, a student might major in animal science, biological sciences, natural resources or development sociology in the College of Agriculture and Life Sciences. Or you might major in biological sciences, English, anthropology in the College of Arts and Sciences or nutrition in the College of Human Ecology. You complete the preprofessional core of courses while at the same time receiving a broad education, and exploring other interests and careers. In this way, you leave open the option of pursuing an alternative career. You are also more likely to succeed at and benefit from subjects that interest and stimulate you, and you leave open the option of pursuing an alternative career.

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What courses should I take?

Veterinary schools, while not requiring or recommending any particular major course of study, do require that particular undergraduate courses be completed. Listed below are the minimum course requirements for admission to the College of Veterinary Medicine at Cornell University. Veterinary Medical School Admission Requirements (VMSAR) contains details for other schools.

English Composition

6 semester credit hours

Biology or Zoology (with laboratory)

6 semester credit hours

Introductory Chemistry (with laboratory)

6 semester credit hours

Organic Chemistry (with laboratory)

6 semester credit hours

Biochemistry

4 semester credit hours

Physics (with laboratory)

6 semester credit hours

General Microbiology (with laboratory)

3 semester credit hours

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Education for becoming a veterinarian: a wider view

In discussing science courses required for entry to veterinary school, it is important to realize that these are only a part of the total educational picture that veterinary schools consider. It is generally agreed that an applicant must be able to perform well in science, to think like a scientist, and even to enjoy science in order to be a competent veterinarian. Being an educated person with an understanding of human nature and human achievement is equally important to veterinarians, both professionally and personally.

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What kinds of animal care related experience do I need?

Veterinary medicine is an animal oriented profession. Therefore, your experiences working with different kinds of animals in different settings and your understanding of the veterinary profession are important consideration in the selection process. Such experience could involve breeding, rearing, feeding and showing various kinds of animals including companion animals, livestock, laboratory animals, zoo animals or wildlife. You should be prepared to present evidence of hands-on experience with animals and sufficient contact with the veterinary profession so that the admissions committee can determine that you have some understanding of the duties and responsibilities of a practitioner and the scope of veterinary medicine.

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What are the acceptance statistics for veterinary schools?

For the classes entering the College of Veterinary Medicine at Cornell University (CVMCU) for the past five years, generally over 20 members of the class were from Cornell. Approximately 100 Cornellians apply to CVMCU each year. No figures are currently available for Cornell students accepted at veterinary schools other than Cornell. Nationally, in 2008 there were over 6,000 applicants to U.S. vet school and over to 2,700 enrolled.

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What is the current employment outlook for vets?

Seventy-five percent of all veterinarians are in private practice, however, veterinarians are employed by government, business, universities, and the military in a wide variety of research, regulatory, and clinical roles. In 2006 the average starting salary for recent graduates was around $56,000 for small animal to $61,000 for large animal practice. The median annual earnings of veterinarians was $72,000 in 2006. Federally employed veterinarians averaged $84,335 in 2007.

Most enrolled need to borrow to cover veterinary college expenses. In order to be able to get loans, be sure to maintain a good credit rating throughout your college years. In 2006 the mean national indebtedness of veterinary graduates was $90,654.

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What is Cornell Accelerated BS/DVM Program?

The double registration program between Cornell University and the College of Veterinary Medicine at Cornell University is approved for students in the College of Agriculture and Life Sciences. It enables a qualified student to save one year in pursuit of the Bachelor and D.V.M. degrees. The program is intended for students who have been admitted to the College of Veterinary Medicine after completing three years of undergraduate work and who have made sufficient progress on the Bachelor's Degree requirements. Certain courses taken in the College of Veterinary Medicine can be used to complete those requirements. Questions about the program may be directed to Jennifer Mailey, Director of Admissions, College of Veterinary Medicine at Vet_admissions@cornell.edu

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What help does Cornell provide for health careers students?

What other resources are available?

A sample of books available in the Career Library, 103 Barnes Hall.

American Animal Hospital Association Accredited Practice Directory American Zoo and Aquarium Membership Directory Career Choices for Veterinarians: Beyond Private Practice, Carin Smith, DVM Careers with Animals, Ellen Shenk Extraordinary Jobs with Animals, Alecia Devantier & Carol Turkington Get Into Veterinary School - Insights by an Admission Expert, Joseph Piekunka Opportunites in Zoo Careers, Sydney J. Butter

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Genetic engineering could save chocolate from going …

February 16th, 2019 9:42 pm

The world's chocolate supply is dwindling. As our global sweet tooth begins to outpace cocoa production, major chocolate companies like Mars Inc. and Barry Callebaut expect to see an industry deficit of 4.4 billion pounds of chocolate by 2030. And by 2050, the cacao seeds used to make chocolate could be extinct.

As farmers struggle to keep up with demand, Bloomberg reports that the price of chocolate has continued to rise, making popular items like Hershey bars more expensive.

Companies that want to keep costs low have had to sacrifice the flavor of their products. In 2014, Bloomberg's Mark Schatzker predicted that chocolate could follow the path of food items like chicken and strawberries, which have lost some of their flavor in the quest to satisfy demand. According to Schatzker, chocolate could soon become "as tasteless as today's store-bought tomatoes."

To prevent that from happening, the nonprofit coalition of farmers called A Fresh Look released a line of chocolate bars that promote the use of genetically modified organisms (GMOs).

Ethos Chocolate uses sugar derived from GMO beets. A Fresh Look

While the bars, known as Ethos Chocolate, don't contain genetically modified cacao an ingredient that's still being developed and tested they do contain sugar that's derived from GMO beets.

According to A Fresh Look's lead scientist, Rebecca Larson, it's the first time a farmer's group has come together to espouse GMO technology, which has been criticized by environmentalists.

Around 70% of the world's cocoa beans hail from West Africa, with Ghana and Ivory Coast serving as the two largest producers. As global temperatures continue to rise, these nations have seen increasingly dry weather, which can prevent cacao trees from growing.

Cacao trees are also particularly vulnerable to disease.

The International Cocoa Organization (ICCO) reported that diseases and pests have resulted in the loss of 30% to 40% of global cocoa production. The report also noted that cocoa species are susceptible to a disease called frosty pod, which has led to entire cocoa farms being abandoned in Latin America.

In West Africa, swollen shoot virus and black pod have also overtaken cacao trees, resulting in huge financial losses. These diseases are made worse by weather conditions such as floods, droughts, and windstorms.

In addition to placing a strain on chocolate manufacturing companies, the loss of cacao trees can impair the livelihoods of tens of millions of people who depend on them economically.

But genetic modification has the potential to lessen these effects by making crops drought tolerant or insect resistant. Studies have shown that GMO crops can improve crop yield, boost farmers' profits, and even reduce the use of pesticides.

While GMOs could be instrumental in saving the world's chocolate supply, they've often been painted as a risk to human health.

Environmental groups contend that GMO crops are more resistant to herbicides, which may or may not be carcinogenic.

Read more: It's almost impossible to avoid GMOs in these 7 everyday items

The 1,600 farmers that make up A Fresh Look have resisted this argument, saying that GMOs are not only safe to consume, but also require less water and improve our nutrition.

A chocolatier in the Ivory Coast explains how cocoa is processed into chocolate. Sia Kambou/AFP/Getty Images

"There's this idea [among consumers] that everything is as mother nature intended, or it was manufactured in a laboratory," Larson told Business Insider. "[We're] helping people understand that GMOs aren't a scary ingredient in their food, but rather a farming technique."

These findings are supported by numerous scientific organizations. In the last two decades, institutions like the National Academy of Sciences, the American Association for the Advancement of Science, and the European Commission have all publicly stated that GMOs don't present harm to human health.

While plenty of chocolate contains ingredients derived from GMOs like corn syrup and soy lecithin, researchers have been slow to develop a genetically modified version of cacao.

Many chocolate companies still cater to consumer preferences for non-GMO items. Ghirardelli, for instance, has publicly stated its mission to make all recipes GMO-free.

One notable exception is Mars, the company behind M&M's and Snickers, which has teamed up with the University of California Berkeley to develop cacao plants that don't wilt or rot. To achieve this, the research team turned to CRISPR, a gene-editing technology that makes small changes to an organism's DNA.

But it could be some time before GMO cacao makes its way onto shelves.

"It all depends on legislative acceptance in different countries where the cacao is being produced," said Larson.

Some of the nations where people buy the most chocolate, such as Germany, Switzerland, and Austria, have restricted their cultivation of GMO crops.

When it comes to consumers, Larson said her team's pro-GMO stance is already starting to catch on: "We've gotten overwhelming feedback from all kinds of industry groups and consumers saying, 'Hey, it's about time.'"

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Dental Stem Cell Potential Explored | Colgate Oral Care

February 16th, 2019 9:41 pm

Scanning through the headlines, tuning in to morning television shows, stem cells are repeatedly the topic of discussion a discussion that increasingly includes primary teeth.

The discovery of stem cells in dental pulp has led to much research and predictions about their potential uses. Although the full possibilities of tooth-derived stem cells are not yet known, some researchers believe that they could one day be valuable for regenerating dental tissues and possibly other tissues as well.

Pamela Robey, Ph.D., chief, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, says that because no one knows for certain what the full possibilities are for the cells isolated from dental pulp, nor can they accurately predict if or when they'll be used in clinical settings, patients and professionals need to make informed decisions.

"What we do know," she said, "is the cells from dental pulp in baby or wisdom teeth have the ability to make dentin and pulp and they might have the ability to make bone but right now that's all we really know for sure."

Because "the data for other things is not hard yet, we can't say how useful for the future they'll be," she said.

Dr. Jeremy Mao, a professor of dental medicine and director of the Tissue Engineering and Regenerative Medicine Laboratory at Columbia University, believes that dental stem cells and related bioengineering technologies will transform dentistry in a magnitude that is far greater than amalgam and dental implants.

"Some of the technologies may happen 10 years down the road but others may happen within 10 years," he predicted.

Presently, there are no human trials taking place with the dental postnatal cells and there are no clinical applications available. There also is no central place for dentists or patients to read about the latest in dental stem cell research. Dr. Robey advised anyone hearing claims of new evidence and dental stem cells to consult the Web site http://www.clinicaltrials.gov.

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Diabetes Basics

February 16th, 2019 1:44 am

Millions of people around the world live with diabetes or know someone living with diabetes. Regardless of the type of diabetes, diabetes isnt yet a curable disease. However, it is a very treatable disease, and no matter how frightening, annoying, and frustrating it can be, people with diabetes can live long, healthy, and happy lives.Our goal is to provide you the information, tools and resources to help make that happen.

This is the place to begin your education about diabetes.

This section of our site provides basic overviews of the major issues surrounding diabetes, with plenty of links to more in-depth information if you need it.

Take our type 2 diabetes risk test for a quick assessment of your risk.

There is no way to predict your chances of getting type 1 diabetes, but you can familiarize yourself with its symptoms.

Type 1 diabetes is usually diagnosed in children and young adults, and was previously known as juvenile diabetes.

Expecting? Learn why women who have never had diabetes may be at risk during pregnancy.

The numbers associated with diabetes make a strong case for devoting more resources to finding a cure.

Clear up some common misunderstandings about what causes diabetes, the effects of diabetes, and how diabetes can be managed.

Become familiar with terms commonly used when discussing diabetes.

Pulitzer prize winning photographer Jay Dickman, volunteered his time and talent to photograph three individuals that are living with diabetes to share their up close and personal daily lives.

These well-known men and women have joined the Association's "Celebrity Cabinet" to help stop diabetes.

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Diabetes Basics

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Integrative Medicine in Philadelphia Healing Arts Center …

February 16th, 2019 1:44 am

Our Integrative Medicine Physician

Steven Rosenzweig, MD graduated from the University of Pennsylvania School of Medicine in 1986 and completed his residency training in Emergency Medicine at Jefferson University Hospital in 1989. He was a full-time Jefferson physician until 2007. During that time he served as the Founding Medical and Academic Director of the Thomas Jefferson University Center of Integrative Medicine, which opened its doors in 1998. In 2007 he established his independent, private practice in Integrative Medicine and also joined the teaching faculty of Drexel University College of Medicine.

Dr. Rosenzweig is Board Certified in Emergency Medicine and Palliative Medicine. He extended his medical training through the study of Anthroposophical Medicine, a European-based system of Integrative Medicine. He participated in professional training under the direction of Jon Kabat-Zinn, PhD, founder of the Stress Reduction Clinic at the University of Massachusetts Medical Center (UMMC), and has completed the Teacher Development Intensive in Mindfulness-Based Stress Reduction offered at the Stress Reduction Clinic at UMMC. He also completed Professional Certification Training in Interactive Guided Imagerysm through the Academy for Guided Imagery.

Dr. Rosenzweig is Clinical Associate Professor at Drexel University College of Medicine where he is Director of the Program in Medical Humanism and Professional Values in the Office of Educational Affairs. He directs courses in Bioethics, Community Service Learning and Professionalism. He teaches mindfulness and Integrative Medicine, and has been developing mind-body projects as part of the community service curriculum. He is also an Adjunct Associate Professor at Jefferson Medical College where he currently lectures on botanical medicine and racial disparities in healthcare. Dr.Rosenzweig is also a member of the medical staff of Hahnemann University Hospital and Abington Memorial Hospital.

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Integrative Medicine in Philadelphia Healing Arts Center ...

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Integrative Oncology Services Abramson Cancer Center

February 16th, 2019 1:44 am

At Penn Medicines Abramson Cancer Center, we are proud to offer integrative oncology services to supplement traditional cancer treatments such as chemotherapy, surgery and radiation therapy. The Abramson Cancer Centers wide range of integrative oncology options are designed to help you minimize or reduce side effects of cancer and cancer treatment, and promote your healing and recovery, and improve your overall sense of well-being.

For more information, read the Integrative Oncology frequently asked questions.

Services include:

Penns Integrative Oncology patient navigator connects patients and families to integrative services at Penn and in the community. She can help schedule an appointment or provide insight into the different therapies offered.

Laura Galindez, MSW, LSWIntegrative Oncology Patient Navigator215-360-0580 or laura.galindez@uphs.upenn.edu

Research being conducted at Penn Medicine tests the effects and mechanisms of promising health behaviors and integrative therapeutic approaches for symptom management and wellness promotion in cancer. Researchers at Penn are exploring ways to best incorporate integrative therapies safely and effectively into the conventional medical therapies to create patient-centered care for optimal health and healing.

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Surrogacy – Wikipedia

February 16th, 2019 1:40 am

This article is about a type of pregnancy. For other uses of the word "surrogacy", see Surrogate. Legal status of surrogacy in the world:

Both gainful and altruistic forms are legal

No legal regulation

Only altruistic is legal

Allowed between relatives up to second degree of consanguinity

Banned

Unregulated/uncertain situation

Surrogacy is an arrangement, often supported by a legal agreement, whereby a woman agrees to become pregnant, carry the pregnancy to due term, and give birth to a child or children, all of this for another person or persons, who are or will ultimately become the parent(s) of the child or children.

People may seek a surrogacy arrangement when pregnancy is medically impossible, when pregnancy risks present an unacceptable danger to the mother's health, or when a man alone or a male couple wishes to have a child. In these arrangements, monetary compensation may or may not be involved. Receiving money for the arrangement is considered commercial surrogacy; receiving no compensation beyond reimbursement of reasonable expenses is altruistic.[1] The legality and cost of surrogacy varies widely between jurisdictions, sometimes resulting in problematic interstate or international surrogacy arrangements.

Laws of some countries restrict or regulate surrogacy and its consequences. Those wanting to seek a surrogacy arrangement who, however, live where it is banned may travel to a jurisdiction that permits it. (See surrogacy laws by country and fertility tourism.)

The fertilisation of the egg may take place in a number of ways, each of which has implications for the genetic relationship of the resulting child with the surrogate and the future parents. There are two main types of surrogacy: gestational surrogacy and traditional surrogacy. In the United States, gestational surrogacy is more common than traditional surrogacy and is considered less legally complex.[2]

Traditional surrogacy (also known as partial, genetic, natural or straight surrogacy[3]) involves natural[4] or artificial insemination of a surrogate. If the intended father's sperm is used in the insemination, then the resulting child is genetically related to the intended father and genetically related to the surrogate. If donor sperm is used, the resulting child is not genetically related to either intended parent but is genetically related to the surrogate.

In some cases, an insemination may be performed privately by the parties without the intervention of a doctor or physician. In some jurisdictions, the 'commissioning parents' using donor sperms need to go through an adoption process in order to have legal rights in respect to the resulting child. Many fertility centers which provide for surrogacy assist the parties through the process.

Gestational surrogacy (also known as host or full surrogacy[3]) was first achieved in April 1986.[5] It takes place when an embryo created by in vitro fertilization (IVF) technology is implanted in a surrogate, sometimes called a gestational carrier. Gestational surrogacy may take a number of forms, but in each form the resulting child is genetically unrelated to the surrogate:

In places where surrogacy is legal, couples may enlist the help of a third party agency to oversee the process of finding a surrogate, entering into a contract with her and recommend fertility centers for insemination, generally via IVF. These agencies can help make sure that surrogates are screened with psychological evaluations and other medical tests so as to ensure the best chance of healthy deliveries. They also usually facilitate all legal matters concerning the two parties (intended parents and surrogate).

Having another woman bear a child for a couple to raise, usually with the male half of the couple as the genetic father, is referred to in antiquity. Babylonian law and custom allowed this practice, and an infertile woman could use the practice to avoid a divorce, which would otherwise be inevitable.[6][7]

Many developments in medicine, social customs, and legal proceedings worldwide paved the way for modern surrogacy:[8]

Surrogacy has the potential for various kinds of clash between surrogate mothers and intended parents. For instance, the intended parents of the fetus may ask for an abortion when complications arise and the surrogate mother may oppose the abortion.[10][11]

Surrogacy is controversial around the world, raising difficult moral, social and legal issues. As a result, the legal situation varies considerably. Many countries do not have laws which specifically deal with surrogacy. Some countries ban surrogacy outright, while others ban commercial surrogacy but allow altruistic surrogacy (in which the surrogate is not financially compensated). Some countries allow commercial surrogacy, with few restrictions. Some jurisdictions extend a ban on surrogacy to international surrogacy. In some jurisdictions rules applicable to adoptions apply and in others the practice is unregulated.

The US, Ukraine, Russia and Georgia have the most liberal laws in the world, allowing commercial surrogacy, including for foreigners.[12] Several Asian countries used to have liberal laws, but the practice has since been restricted. In 2015, Thailand banned commercial surrogacy, and restricted altruistic surrogacy to Thai couples.[13] In 2016, Cambodia also banned commercial surrogacy.[14] Nepal, Mexico, and India, have also recently banned foreign commercial surrogacy.[15] Surrogacy is legal and common in Iran; and monetary remuneration is practiced and allowed by religious authorities.[16][17]

Laws dealing with surrogacy must deal with:

Although laws differ widely from one jurisdiction to another, some generalizations are possible:

The historical legal assumption has been that the woman giving birth to a child is that child's legal mother, and the only way for another woman to be recognized as the mother is through adoption (usually requiring the birth mother's formal abandonment of parental rights).

Even in jurisdictions that do not recognize surrogacy arrangements, if the genetic parents and the birth mother proceed without any intervention from the government and have no changes of heart along the way, they will likely be able to achieve the effects of surrogacy by having the surrogate mother give birth and then give the child up for private adoption to the intended parents.

If the jurisdiction specifically prohibits surrogacy, however, and authorities find out about the arrangement, there may be financial and legal consequences for the parties involved. One jurisdiction (Quebec) prevented the genetic mother's adoption of the child even though that left the child with no legal mother.[18]

Some jurisdictions specifically prohibit only commercial and not altruistic surrogacy. Even jurisdictions that do not prohibit surrogacy may rule that surrogacy contracts (commercial, altruistic, or both) are void. If the contract is either prohibited or void, then there is no recourse if one party to the agreement has a change of heart: if a surrogate changes her mind and decides to keep the child, the intended mother has no claim to the child even if it is her genetic offspring, and the couple cannot get back any money they may have paid or reimbursed to the surrogate; if the intended parents change their mind and do not want the child after all, the surrogate cannot get any reimbursement for expenses, or any promised payment, and she will be left with legal custody of the child.

Jurisdictions that permit surrogacy sometimes offer a way for the intended mother, especially if she is also the genetic mother, to be recognized as the legal mother without going through the process of abandonment and adoption. Often this is via a birth order[19] in which a court rules on the legal parentage of a child. These orders usually require the consent of all parties involved, sometimes including even the husband of a married gestational surrogate. Most jurisdictions provide for only a post-birth order, often out of an unwillingness to force the surrogate mother to give up parental rights if she changes her mind after the birth.

A few jurisdictions do provide for pre-birth orders, generally in only those cases when the surrogate mother is not genetically related to the expected child. Some jurisdictions impose other requirements in order to issue birth orders: for example, that the intended parents be heterosexual and married to one another. Jurisdictions that provide for pre-birth orders are also more likely to provide for some kind of enforcement of surrogacy contracts.

The citizenship and legal status of the children resulting from surrogacy arrangements can be problematic. The Hague Conference Permanent Bureau identified the question of citizenship of these children as a "pressing problem" in the Permanent Bureau 2014 Study (Hague Conference PermanentBureau, 2014a: 84-94).[20][21] According to U.S. Department of State, Bureau of Consular Affairs, for the child to be a U.S. citizen one or both of the child's genetic parents must be a U.S. citizen. In other words, the only way for the child to acquire U.S. citizenship automatically at birth is if he/she is the biological son or daughter of a U.S. citizen. Further, in some countries, the child will not be a citizen of the country in which he/she is born because the surrogate mother is not legally the parent of said child. This could result in a child being born without citizenship.[22]

Ethical issues that have been raised with regards to surrogacy include the following:[23]

Different religions take different approaches to surrogacy, often related to their stances on assisted reproductive technology in general.

Paragraph 2376 of the Catechism of the Catholic Church states that: "Techniques that entail the dissociation of husband and wife, by the intrusion of a person other than the couple (donation of sperm or ovum, surrogate uterus), are gravely immoral."[24]

Jewish legal scholars debate this issue. Some contend that parenthood is determined by the woman giving birth while others opt to consider the genetic parents the legal parents.[25][26] Some Jewish religious establishments have accepted surrogacy only if it is full gestational surrogacy with both intended parents' gametes included and fertilization done via IVF.[27]

Hindu scholars have not debated the issue. TC Anand Kumar argues that here is no conflict between Hinduism and assisted reproduction.[28].

Jain scholars have not debated the issue. In the Shvetambara tradition of Jainism, the embryo of Lord Mahavira was transferred from a Brahmin woman Devananada to the womb of Trishala, the queen of Kshatriya ruler Siddharth, by a divinity named Harinegameshin.[29] The account is not present in the Digambara Jain texts.

A study by the Family and Child Psychology Research Centre at City University London in 2002 concluded that surrogate mothers rarely had difficulty relinquishing rights to a surrogate child and that the intended mothers showed greater warmth to the child than mothers conceiving naturally.[30][31][32]

Anthropological studies of surrogates have shown that surrogates engage in various distancing techniques throughout the surrogate pregnancy so as to ensure that they do not become emotionally attached to the baby.[33][34] Many surrogates intentionally try to foster the development of emotional attachment between the intended mother and the surrogate child.[35]

Surrogates who work with an agency are generally counseled by the agency to become emotionally detached from the fetus prior to giving birth.[36]

Some surrogates describe feeling empowered by the experience.[34][37]

Although surrogate mothers generally report being satisfied with their experience as surrogates, there are cases in which they are not. Unmet expectations are associated with dissatisfaction. Some women did not feel a certain level of closeness with the couple and others did not feel respected by the couple.[38]

Some women experience emotional distress as a surrogate mother. There may be a lack of access to therapy and emotional support through the surrogate process.[38]

Some surrogate mothers have reactions that include depression when surrendering the child, grief, and even refusal to release the child.[39]

A 2011 study from the Centre for Family Research at the University of Cambridge found that surrogacy does not have a negative impact on the surrogate's own children.[40]

A study has followed a cohort of 32 surrogacy, 32 egg donation, and 54 natural conception families through to age seven, reporting the impact of surrogacy on the families and children at ages one,[32] two,[41] and seven.[42] At age one, parents through surrogacy showed greater psychological well-being and adaptation to parenthood than those who conceived naturally; there were no differences in infant temperament. At age two, parents through surrogacy showed more positive motherchild relationships and less parenting stress on the part of fathers than their natural conception counterparts; there were no differences in child development between these two groups. At age seven, the surrogacy and egg donation families showed less positive motherchild interaction than the natural conception families, but there were no differences in maternal positive or negative attitudes or child adjustment. The researchers concluded that the surrogacy families continued to function well.

In Australia, all jurisdictions except the Northern Territory allow altruistic surrogacy, but commercial surrogacy is a criminal offense. The Northern Territory has no legislation governing surrogacy.[43] In New South Wales, Queensland and the Australian Capital Territory it is an offence to enter into international commercial surrogacy arrangements, with potential penalties extending to imprisonment for up to one year in Australian Capital Territory, up to two years in New South Wales and up to three years in Queensland.

Altruistic surrogacy was legalized in Belgium.

The Assisted Human Reproduction Act (AHRC) permits only altruistic surrogacy: surrogate mothers may be reimbursed for approved expenses but payment of any other consideration or fee is illegal.[44]

Altruistic surrogacy was legalized in Denmark.

Gainful surrogacy is made illegal by the Charter of Fundamental Rights, whose Article 3 states that "making the human body and its parts as such a source of financial gain" is prohibited.[45]

Surrogacy has been illegal since law amendment in 2007. Children born abroad for Finnish parents by surrogacy will not be entitled to get Finnish Citizenship.

All surrogacy arrangements (both commercial and altruistic) are illegal. German party FDP wants to allow altruistic surrogacy.[46]

Law 3305/2005 (Enforcement of Medically Assisted Reproduction) makes surrogacy in Greece fully legal. Greece is only one of a handful of countries in the world to give legal protection to intended parents. Intended parents must meet certain qualifications and will go before a family judge before entering into a surrogacy contract. As long as they meet the qualifications, the court appearance is procedural and their application will be granted. At present, intended parents must be in a heterosexual partnership or be a single female. Females must be able to prove there is a medical indication they cannot carry and be no older than 50 at the time of the contract. As in all jurisdictions, surrogates must pass medical and psychological tests so they can prove to the court that they are medically and mentally fit. Greece is the only country in Europe, and one of only countries in the world, where the surrogate then has no rights over the child. The intended parents become the legal parents from conception, and there is no mention of the surrogate mother anywhere on hospital or birth documents. The intended parent(s) are listed as the parents. This even applies if an egg or sperm donor is used by one of the partners. As a result of the Schengen Treaty, intended parents from throughout Europe can freely travel home as soon as the baby is born and deal with citizenship issues at that time, as opposed to applying at their own embassy in Greece. Before 2014 (pursuant to art. 8 of Law 3089/2002), the surrogate mother and the commissioning parents were required to be Greek citizens or permanent residents. However, in July 2014, L. 4272/2014 extended legal surrogacy to applicants or surrogate mothers who have either permanent or temporary residence in Greece.

There is no law in Ireland governing surrogacy. In 2005 a Government appointed Commission published a comprehensive report on Assisted Human Reproduction, which made many recommendations on the broader area of assisted human reproduction. In relation to surrogacy it recommended that the commissioning couple would under Irish law be regarded as the parents of the child. Despite the publication there has been no legislation published, and the area essentially remains unregulated. Due to mounting pressure from Irish citizens going abroad to have children through surrogacy, the Minister for Justice, Equality and Defence published guidelines for them on 21 February 2012.[47]

Altruistic surrogacy was legalized in the Netherlands.

Altruistic surrogacy is legal, but commercial surrogacy is not.

Gestational surrogacy is currently practiced in Nigeria by a few IVF clinics, under practice guidelines from the Association of Fertility and Reproductive Health of Nigeria. An assisted reproduction technology regulation being considered by the Senate permits surrogacy and allows payments for transport and other expenses.[48]

In 2016, gestational surrogacy was legalized in Portugal. Discussions on the adoption of this law lasted more than 3 years. The first version of the law was adopted May 13, 2016, but the president vetoed it. He demanded that the law specify the rights and obligations of all participants.

Portugal allows surrogacy only for those couples in which the woman cannot carry and give birth to a child for medical reasons. Only altruistic surrogacy is permitted. A written agreement must be issued between the surrogate mother and the genetic parents. The rights and obligations of the parties as well as their actions in cases of force majeure should be included in it. After the birth, parental rights over the child belong to the genetic parents.

Traditional surrogacy (in which the surrogate is a genetic parent) is illegal in Portugal.

Heterosexual and lesbian couples can become parents via surrogacy in Portugal under the 2016 law. Male homosexual couples and single men and women of any sexual orientation have not yet been included, but they are not addressed specifically. A revision to include them is on the current manifestos of the Left Bloc, PeopleAnimalsNature, and The Greens). The right-wing party CDS-PP and the Portuguese Communist Party are opposed.

The South Africa Children's Act of 2005 (which came fully into force in 2010) enabled the "commissioning parents" and the surrogate to have their surrogacy agreement validated by the High Court even before fertilization. This allows the commissioning parents to be recognized as legal parents from the outset of the process and helps prevent uncertainty. If the surrogate mother is the genetic mother, however, she has until 60 days after the birth of the child to change her mind. The law permits single people and gay couples to be commissioning parents.[49] However, only those domiciled in South Africa benefit from the protection of the law, no non-validated agreements will be enforced, and agreements must be altruistic rather than commercial. If there is only one commissioning parent, s/he must be genetically related to the child. If there are two, they must both be genetically related to the child unless that is physically impossible due to infertility or sex (as in the case of a same sex couple). The commissioning parent or parents must be physically unable to birth a child independently. The surrogate mother must have had at least one pregnancy and viable delivery and have at least one living child. The surrogate mother has the right to unilaterally terminate the pregnancy, but she must consult with and inform the commissioning parents, and if she is terminating for a non-medical reason, may be obliged to refund any medical reimbursements she had received.[50]

The Spanish Human Assisted Reproductive Technologies Act of 2006 made surrocagy arrangements, either commercial or altruistic, null and void. Thus, the intended mother won't be recognised as such; the woman who gives birth will be the legal mother. On the other hand, the biological father will have an action to claim his paternity, by acknowledgment or judicial claim. Despite the aforementioned, surrogacy arrangements made abroad are recognised by Spanish authorities in some circumstances.

In June 2017, the political party Ciudadanos registered a bill in the Congress of the Deputies to legalise altruistic surrogacy. No other political party supports this idea.

Altruistic surrogacy remains illegal in Sweden.

Commercial surrogacy arrangements are not legal in the United Kingdom. Such arrangements were prohibited by the Surrogacy Arrangements Act 1985.[51] Whilst it is illegal in the UK to pay more than expenses for a surrogacy, the relationship is recognised under section 30 of the Human Fertilisation and Embryology Act 1990. Regardless of contractual or financial consideration for expenses, surrogacy arrangements are not legally enforceable so a surrogate mother maintains the legal right of determination for the child, even if they are genetically unrelated. Unless a parental order or adoption order is made, the surrogate mother remains the legal mother of the child.

Surrogacy and its attendant legal issues fall under state jurisdiction and the legal situation for surrogacy varies greatly from state to state. Some states have written legislation, while others have developed common law regimes for dealing with surrogacy issues. Some states facilitate surrogacy and surrogacy contracts, others simply refuse to enforce them, and some penalize commercial surrogacy. Surrogacy-friendly states tend to enforce both commercial and altruistic surrogacy contracts and facilitate straightforward ways for the intended parents to be recognized as the child's legal parents. Some relatively surrogacy-friendly states offer support only for married heterosexual couples. Generally, only gestational surrogacy is supported and traditional surrogacy finds little to no legal support.

States generally considered to be surrogacy friendly include California,[52] Oregon,[53] Illinois,[54] Arkansas,[55] Maryland,[56] New Hampshire,[57] New Jersey (effective from 1/1/2019) and Washington State (eff. 1/1/2019).[58][59]

For legal purposes, key factors are where the contract is completed, where the surrogate mother resides, and where the birth takes place. Therefore, individuals living in a non-friendly state can still benefit from the policies of surrogacy friendly states by working with a surrogate who lives and will give birth in a friendly state.

Fertility tourism for surrogacy is driven by legal regulations in the home country or lower price abroad.

India is a main destination for surrogacy. Indian surrogates have been increasingly popular with intended parents in industrialized nations because of the relatively low cost. Clinics charge patients between $10,000 and $28,000 for the complete package, including fertilization, the surrogate's fee, and delivery of the baby at a hospital. Including the costs of flight tickets, medical procedures and hotels, it comes to roughly a third of the price compared with going through the procedure in the UK.[60]

Surrogacy in India is of low cost and the laws are flexible. In 2008, the Supreme Court of India in the Manji's case (Japanese Baby) has held that commercial surrogacy is permitted in India. That has increased the international confidence in surrogacy arrangements in India. As of 2014, however, surrogacy by homosexual couples and single parents was banned[citation needed].

There is an upcoming Assisted Reproductive Technology Bill, aimed at regulating the surrogacy business. It may increase parent confidence in clinics by eliminating dubious practitioners, and in this way stimulate the practice.[60]

Liberal legislation makes Russia attractive for those looking for techniques not available in their countries. Intended parents come there for oocyte donation, because of advanced age or marital status (single women and single men), and when surrogacy is considered. Commercial gestational surrogacy is legal in Russia, being available to almost all adults willing to be parents.[61] Foreigners have the same rights to assisted reproduction as Russian citizens. Within three days after the birth, the commissioning parents obtain a Russian birth certificate with both their names on it. Genetic relation to the child (in case of donation) is not a factor.[62]On August 4, 2010, a Moscow court ruled that a single man who applied for gestational surrogacy (using donor eggs) could be listed on the birth certificate as the only parent of his son.[63]

Surrogacy is legal in Ukraine. Only healthy women who have had children before can become surrogates. Surrogates in Ukraine have no parental rights over the child, as stated on Article 123 of the Family Code of Ukraine. Thus, a surrogate cannot refuse to hand the baby over if she changes her mind after birth. Only married couples can legally go through gestational surrogacy in Ukraine.

People come to the US for surrogacy procedures for the high quality of medical technology and care, as well as the high level of legal protections afforded through some US state courts to surrogacy contracts as compared to many other countries. Single men or male couples who face restrictions using IVF and surrogacy procedures in their home countries may travel to US states with favorable legal climates. The United States is occasionally sought as a location for surrogate mothers by couples seeking a green card in the U.S., since the resulting child can get birthright citizenship in the United States and can thereby apply for green cards for the parents when the child turns 21 years of age.[64]

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Additional Services | Integrative Medicine of New Jersey

February 13th, 2019 10:44 pm

The following services are available to patients of Integrative Medicine of New Jersey:

Aesthetic Services:

Gemini Laser Laser Skin Rejuvenation & Pigmentation Treatment

The Gemini Laser can selectively treat a variety of skin problems with minimal or no disruption to the surrounding normal skin:

The Gemini Laser cannot treat moles or skin cancers.

It is most commonly used on the face, neck, chest, back, and hands.

The first step is simply contacting us for your initial laser skin rejuvenation consultation. We will discuss with you what is a realistic and achievable outcome, and what to expect from your laser treatment.

Homeopathic Facial Mesotherapy

As we age, our skin loses vital nutrients as a result of sun exposure, hormonal changes, poor diet and poor circulation. Homeopathic facial mesotherapy, also known as anti-aging mesotherapy, uses intra-dermal injections of a nutritive and moisturizing solution to improve brightness, skin hydration and tonus, and also smooth out superficial wrinkles. This technique delivers the required nutrients like those naturally found in the body vitamins, amino acids, co-enzymes, collagen and antioxidants to particular areas of the skin. Concentration of these molecules in homeopathic medicines aims to rejuvenate the cells, making them more active, and thereby stimulating the production of collagen and elastin without the involvement of toxins. With this revolutionary face treatment you will experience: restoration of skin elasticity, improvement of skin tone, firming and tightening of the skin and a reduction of visible wrinkles. Integrative Medicine of New Jersey uses only safe, natural, and effective FDA approved homeopathic solutions from GUNA.

Platelet-Rich Plasma Therapy (PRP) Stem Rejuvenation

Platelet-rich plasma (PRP) therapy, also known as Stem Rejuvenation, involves injection of the patients own platelets and fibrin for the cosmetic treatment of wrinkles or scars in the face, hands, and neck. It is not invasive, takes about one hour for each treatment, and continues to show improvements for up to 18 months as stem cells continually work to rejuvenate the skin creating more collagen and a beautiful shine. Cost of the procedure is generally similar to that of fillers and may range from $900 to $1,200 per treatment.Platelets play a role in stopping bleeding and in repairing damaged blood vessels and cells in the body. Platelets also contain substances called growth factors that activate and rejuvenate cells in our body. PRP uses the patients natural biology to address skin defects and volume loss, triggering production of new cells and collagen formation.

This cutting-edge rejuvenation is a quick one hour procedure. After 50ml of blood is drawn from the patient, it is spun down in a centrifuge for 6 minutes at a precalculated speed to retrieve the most viable fibrin and platelets. After centrifugation, the platelet and fibrin component of the blood (the top layer) is extracted and reinjected into the area of concern.For those looking to delay the aging process, Stem Rejuvenation is a new facial rejuvenation procedure that promises to reverse the aging process and reduce the appearance of wrinkles, lines and blemishes.Stem Rejuvenation is a natural product that utilizes regenerated cells and allows individuals to appear younger within a short period of time. The targeted Stem Rejuvenation audience is people who are looking for a younger rejuvenated look. The procedure can be done in your doctors office with minimal pain. The most common side effects include, but are not limited to, temporary injection site reactions such as redness, pain/tenderness, swelling, lumps/bumps, bruising and some patients experience headaches. These side effects usually dont last past 48 hours.

Diagnostic Services:

Allergy Testing

In allergic people, an excess of a certain antibody called IgE is often produced. These IgE antibodies react and release inflammatory chemicals when they contact allergens (e.g. pollens, dust mites, mold spores, animal dander, foods, drugs, dyes) and then allergy symptoms are produced.

The measurement of IgE antibodies is the key to effective allergy diagnosis and treatment. The doctor may choose to test the patient using skin tests, a blood test, or both. In years past, the only method of testing for allergies was by scratching or injection a liquid extract of the suspected offending substance(s) into the skin and observing it for development of a welt. Now it is possible to use a blood test to measure a patients IgE antibodies to a wide variety of allergens. A small sample of blood can be analyzed in the laboratory for a safe and accurate diagnosis. Skin tests and the blood test are often used to confirm one another. Both tests provide the doctor with information to help her decide how your allergies should be treated. Each patients treatment is customized and tailored to the patients lifestyle.

ANSAR (Autonomic Nervous System Monitoring)

The autonomic nervous system (ANS) is the part of your nervous system which functions to sustain life by helping to control your heart, lungs, digestive system, blood pressure, immune system, certain reflexes, fluid balance, pupil diameter, sleep, sweating, hormones, kidney, and sexual function. There are two branches, or parts within your autonomic nervous system; the sympathetic branch and the parasympathetic branch. Generally, the sympathetic branch is more in control when you are stressed, nervous, or excited, while the parasympathetic branch is more in control when you are relaxing, sleeping, or recovering from an illness or injury. A balance between the two branches is essential for good health. Most illnesses and injuries can cause (or result from) an imbalance between these two branches.

Autonomic nervous system monitoring is a fast, non-invasive, and simple way to provide your doctor with information to help determine how healthy you are. Everyone from newborns to older adults can and should have their ANS monitored. ANS monitoring records your ECG and respiratory activity. Blood pressure readings are also taken. Your ECG and respiratory activity are analyzed by the ANS monitor to determine how your ANS is controlling your heart, lungs, and other vital organs of your body. Your doctor then interprets your Parasympathetic and Sympathetic (P&S) results produced by the ANS Monitor. Too much or too little P&S activity is not healthy. This information can help your doctor adjust your balance for better health.

Cardiac Health Screen Holter Monitor

Holter monitoring (24h) refers to a 24-hour, continuous test to record your heart rate and rhythm. This device has electrodes and electrical leads exactly like a regular electrocardiogram. A patient wears the Holter monitor for 12 to 48 hours as they go about their normal daily routines. This testing is ordered when your doctor needs more information about the functioning of your heart than a routine electrocardiogram (EKG) can give her.

Why do people wear Holter monitors?

Regular electrocardiograms (ECGs or EKGs) let your doctor look at your hearts activity at one point in time during your ECG test. But abnormal heart rhythms and cardiac symptoms may come and go. Thats why your doctor may want to evaluate your heartbeat over time while you go about your normal activities. You may be asked to wear a Holter monitor if you have fast, slow or irregular heartbeats called arrhythmias.

Wearing the monitor may tell your doctor:

Micronutrient Testing

Vitamin, mineral and antioxidant deficiencies have been shown to suppress the function of the immune system which can contribute to degenerative processes such as arthritis, cancer, cardiovascular disease and diabetes. You may be deficient in some vitamins, minerals, antioxidants, and/or other essential micronutrients and not even know it.

Test results do not typically measure if the nutrient is properly functioning within the body. Our office uses testing that measures the function of selected vitamins, minerals, antioxidants and other essential micronutrients within your white blood cells. Analysis can reveal a persons functional nutrient status over a much longer time period than conventional serum testing. Get your micronutrient tests today. The test results provide the information needed to create your personalized supplementation and repletion program.

Neurotransmitter Testing

The following symptoms can be triggered by nervous system imbalances: low mood, anxiousness, fatigue, difficulty falling asleep, difficulty staying asleep, trouble focusing, poor memory, weight gain.

A simple urine test can identify which neurotransmitter(s) may be playing a role in your health concerns. Neurotransmitter test results are like neural fingerprints, each one is unique and provides your doctor with a wealth of information. Once your doctor knows which neurotransmitters are elevated and which are low, she can help you select the therapies, lifestyle adjustments, and nutritional support products you need to restore balance.

Additional Therapeutic Services:

IV Therapy:

Vitamin C DripMineral DripImmune Tune-UpGlutathione IV PushChelation EDTA

Vitamin IV

Uses for Vitamin IV therapy:

Asthma attacksAdrenal Stress InsufficiencyMalabsorptionAcute Bacterial and Viral IllnessesAllergic DisordersPMSHeadachesImmune System BoosterRemoval of Heavy MetalsIncreases Energy Level

Call Integrative Medicine of New Jersey at (973) 736-5300 for more information and to schedule your appointment.

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Dental Stem Cells in Chicago, IL | Harold Krinsky, DDS

February 13th, 2019 10:43 pm

Stem Cell Intro

Ordinary cells in your body replicate to make new cells of the same type blood cells make more blood cells, skin cells make more skins cells and so on. However, there is another type of cell, called a stem cell.

Stem cells are able to repair or replace damaged tissue. This is why scientists and doctors are so excited about the growing role of stem cells to treat disease, injury, and the deterioration of tissue due to aging. Amazingly, after our birth and into adulthood, we keep a store of these stem cells in certain parts of our body.

Different types of stem cells exist in different body tissues, and in varying concentrations. One of the most well-understood and widely researched types of stem cells is the mesenchymal stem cell.

Mesenchymal stem cells can form tissues such as bone, nerve, muscle and blood vessels. They also help body tissue to repair itself, and they play an important role in healing by suppressing inflammation.

Though located in a number of places in the body, mesenchymal stem cells can be found in especially high concentrations in the healthy dental pulp of teeth.

Over time, even stem cells succumb to the environmental insults that age all of our cells. Freezing cells in a youthful state preserves their future ability to generate replacement tissue and heal the body.

All of these attributes make stem cells the cornerstone of the emerging field of treatments and therapies called Regenerative Medicine.

Mesenchymal stem cells have already proven to be a powerful and potent platform for developing treatments. As you are reading this, scientists are studying the role of these amazing cells in treating conditions such as type 1 diabetes, spinal cord injury, stroke, myocardial infarction (heart attack), corneal damage and neurological diseases like Parkinsons, to name just a few.

Hundreds of clinical trials are underway, demonstrating the use of mesenchymal stem cells to treat diseases, to heal injuries, and to grow replacement tissues like bone, nerve, muscle and blood vessels. In fact, mesenchymal stem cells are currently being tested clinically to treat autoimmune diseases like Crohns and GVHD as well as in regenerative applications like bone and cartilage repair and cardiac muscle repair after myocardial infarction.

This exploding field of research, called Regenerative Medicine, holds the promise that your child, utilizing a toolkit of their own stem cells harvested and stored early on, will live a life of unprecedented wellness. Regenerative medical therapies could become common treatments used alongside more traditional ones.

Imagine a future where serious conditions like type 1 diabetes are treated with a combination of drugs and regenerative medicine. Imagine skin and bone grafts created from the patients own cells. Imagine treating age-related conditions like arthritis, dementia, and Alzheimers using cells from the patients teeth that were banked when they were young.

Want to dig deeper into emerging therapies using mesenchymal stem cells?

To learn more, visit http://www.store-a-tooth.com or call (877) 867-5753 to speak with a client educator.

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Neurogenesis – Wikipedia

February 12th, 2019 4:43 pm

Neurogenesis is the process by which nervous system cells, known as neurons, are produced by neural stem cells (NSC)s, and it occurs in all species of animals except the porifera (sponges) and placozoans.[1] Types of NSCs include neuroepithelial cells (NECs), radial glial cells (RGCs), basal progenitors (BPs), intermediate neuronal precursors (INP)s, subventricular zone astrocytes, and subgranular zone radial astrocytes, among others.[2] Neurogenesis is most active during embryonic development, and is responsible for producing all the various types of neurons of the organism, but continues throughout adult life in a variety of organisms.[3] Once born, neurons do not divide (see mitosis), and many will live the lifetime of the animal.[4]

During embryonic development, the mammalian central nervous system (CNS; brain and spinal cord) is derived from the neural tube, which contains NSCs that will later generate neurons.[5] However, neurogenesis doesn't begin until a sufficient population of NSCs has been achieved. These early stem cells are called neuroepithelial cells (NEC)s, but soon take on a highly elongated radial morphology and are then known as radial glial cells (RGC)s.[6] RGCs are the primary stem cells of the mammalian CNS, and reside in the embryonic ventricular zone, which lies adjacent to the central fluid-filled cavity (ventricular system) of the neural tube.[7][8] Following RGC proliferation, neurogenesis involves a final cell division of the parent RGC, which produces one of two possible outcomes. First, this may generate a subclass of neuronal progenitors called intermediate neuronal precursors (INP)s, which will divide one or more additional times to produce neurons. Alternatively, daughter neurons may be produced directly. Neurons do not immediately form neural circuits through the growth of axons and dendrites. Instead, newborn neurons must first migrate long distances to their final destinations, maturing and finally generating neural circuitry. For example, neurons born in the ventricular zone migrate radially to the cortical plate, which is where neurons accumulate to form the cerebral cortex.[9][10] Thus, the generation of neurons occurs in a specific tissue compartment or 'neurogenic niche' occupied by their parent stem cells.

The rate of neurogenesis and the type of neuron generated (broadly, excitatory or inhibitory) are principally determined by molecular and genetic factors. These factors notably include the Notch signaling pathway, and many genes have been linked to Notch pathway regulation.[11][12] The genes and mechanisms involved in regulating neurogenesis are the subject of intensive research in academic, pharmaceutical, and government settings worldwide.

The amount of time required to generate all the neurons of the CNS varies widely across mammals, and brain neurogenesis is not always complete by the time of birth.[13] For example, mice undergo cortical neurogenesis from about embryonic day (post-conceptional day) (E)11 to E17, and are born at about E19.5.[14] Ferrets are born at E42, although their period of cortical neurogenesis does not end until a few days after birth.[15] In contrast, neurogenesis in humans generally begins around gestational week (GW) 10 and ends around GW 25 with birth about GW 38-40.[16]

Adult neurogenesis has been shown to occur at low levels compared with development, and in only two regions of the brain: the adult subventricular zone (SVZ) of the lateral ventricles, and the dentate gyrus of the hippocampus.[17][18][19]

In many mammals, including for example rodents, the olfactory bulb is a brain region containing cells that detect smell, featuring integration of adult-born neurons, which migrate from the SVZ of the striatum to the olfactory bulb through the rostral migratory stream (RMS).[20][21] The migrating neuroblasts in the olfactory bulb become interneurons that help the brain communicate with these sensory cells. The majority of those interneurons are inhibitory granule cells, but a small number are periglomerular cells. In the adult SVZ, the primary neural stem cells are SVZ astrocytes rather than RGCs. Most of these adult neural stem cells lie dormant in the adult, but in response to certain signals, these dormant cells, or B cells, go through a series of stages, first producing proliferating cells, or C cells. The C cells then produce neuroblasts, or A cells, that will become neurons.[22]

Significant neurogenesis also occurs during adulthood in the hippocampus of many mammals, from rodents to some primates, although its existence in adult humans is debated.[23][24] The hippocampus plays a crucial role in the formation of new declarative memories, and it has been theorized that the reason human infants cannot form declarative memories is because they are still undergoing extensive neurogenesis in the hippocampus and their memory-generating circuits are immature.[25] Many environmental factors, such as exercise, stress, and antidepressants have been reported to change the rate of neurogenesis within the hippocampus of rodents.[26][27] Some evidence indicates postnatal neurogenesis in the human hippocampus decreases sharply in newborns for the first year or two after birth, dropping to "undetectable levels in adults."[28]

Neurogenesis has been best characterized in the fruit fly, Drosophila melanogaster.[29] In Drosophila, Notch signaling was first described, controlling a cell-to-cell signaling process called lateral inhibition, in which neurons are selectively generated from epithelial cells.[30][31] In some vertebrates, regenerative neurogenesis has also been shown to occur.[32]

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What is Personalized Medicine | Abbott Companion Diagnostics

February 12th, 2019 4:42 pm

Personalized Medicine is defined as the customization of healthcare, where medical decisions are tailored to the individual patient based on their susceptibility to disease or response to a particular treatment. A key component of personalized medicine includes advanced testing of a patient's genetic information to help identify targeted treatment options.The practice of personalized medicine is based on the premise that for many diseases, including cancer, there is no one-size-fits-all treatment. In personalized medicine, diagnostic tests are used to help tailor disease prevention, diagnosis, and treatment based on the genetic makeup of a particular patient.1

At Abbott Molecular, we know that when patients and physicians are informed about the diagnostic and treatment opportunities offered by the promise of personalized medicine, lives can be saved. VisitRichard's Storyto learn about how personalized medicine has provided options and hope to patients and their families.

Companion Diagnostics (CDx) are laboratory tests developed in parallel with particular drugs to identify patients who are most likely to benefit from treatment with these drugs. Information from test results helps physicians to personalize patient treatment plans. Generally speaking, the practice of personalized medicine has been described as providing the right patient with the right drug at the right dose at the right time."1According to the Food and Drug Administration, personalized medicine may be considered as customizing medical treatment to the individual characteristics, needs, and preferences of a patient during all stages of care, including prevention, diagnosis, treatment, and follow-up.2

Many of the world's leading pharmaceutical, biological, and entrepreneurial companies select Abbott Molecular as their companion to develop comprehensive, companion diagnostic products and strategies.

There is no typical cancer patient. People diagnosed with cancer represent various races, ages, and lifestyles. Working with your physician to understand the causes, diagnosis, and treatment of cancer may help minimize concerns and is a positive first step in any fight against the disease. The following categories of frequently asked questions are provided for educational purposes only and are not intended to replace discussions with your healthcare provider.

1, 2http://www.fda.gov/ScienceResearch/SpecialTopics/PersonalizedMedicine/ucm20041021.htm. Accessed 3.25.14.

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Selected topics in genetics & personalized medicine …

February 12th, 2019 4:42 pm

Genetic testing

TheHuman Genome Projectled to the discovery of thousands of disease genes. Genetic testing can help patients determine disease risk and the likelihood of passing on or inheriting certain disorders.

Learn more aboutgenetic testingand how to use this information in your practice.

LINKS 1-6: Topics in genetics & personalized medicine

Genetic testing is expected to become a routine part of patient care in the future, but unless this DNA information is protected, the potential grows for discrimination against people based on their genetic information.

Understand more aboutgenetic discrimination.

LINKS 1-6: Topics in genetics & personalized medicine

Gene patentingis a broad term referring to the patenting of genetic sequences such as DNA and RNA, and to alternative forms of DNA such as cDNA (complementary DNA).

Learn more aboutgene patentingand its impact on patient care.

LINKS 1-6: Topics in genetics & personalized medicine

Direct-to-Consumer (DTC) genetic tests are marketed and sold directly to consumers, and do not require the assistance of a physician or other health care provider to obtain or interpret.

Learn aboutDTC genetic tests.

LINKS 1-6: Topics in genetics & personalized medicine

Precision medicine is a tailored approach to health care that accounts for the individual variability in the genes, environment and lifestyle of each person.

Learn more aboutprecision medicineand the President's Precision Medicine Initiative.

LINKS 1-6: Topics in genetics & personalized medicine

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SCGPM | Stanford Center for Genomics and Personalized …

February 12th, 2019 4:42 pm

Cancer Genomes

Cancer is a genetic disease. It starts with one unlucky cell that loses control over growth and division and evades the immune system; it continues with accumulation of mutations in the genome of its progeny that make them grow even faster; and it eventually reaches the point where it is detected by a physician. SCGPM researchers are devising new approaches to study genomic changes in cancers, to understand cancer origins and progression, and to determine which altered genes might be developed into drug targets.

The human brain has 100 billion neurons that govern how we think, feel, learn, and remember. Defects in the formation of these neurons during development can lead to mental retardation, and during aging or in diseases such as Alzheimer's, there is a decline in cognitive function, particularly memory. SCGPM scientists are identifying the molecular changes that occur in brain cells during development, aging, and diseases. Identifying these molecular changes will provide new avenues to ameliorate neurological diseases and to prevent age-dependent decline in cognitive function.

SCGPM scientists are investigating the genetic basis of Mendelian, oligogenic, and complex human cardiovascular diseases employing high-throughput sequencing of informative families and association-based whole genome scanning methodologies with large case-control cohorts. Causal genetic variation identified through these approaches is under investigation to elucidate the mechanistic basis for the disease associations.

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