StemCell Therapy

Abstract

Changes in the gut microbiome caused by antibiotics can impair immune responses to influenza vaccination.

Many facets of the immune system have been shown to be affected by the bacteria that live on us and within us. However, the mechanisms of these effects remain unclear, especially in human immunology. Prior investigations highlighted the potential impact of commensal microorganisms on vaccine responses but have left many questions. Hagan et al. recruited a cohort of healthy adults (n = 22) and vaccinated for influenza (on day 0). Half of the participants were pretreated with antibiotics (day -3day 1). Hagan et al. measured the effect of antibiotics on gut microbiome with a stool 16S rRNA sequencing time course. Antibiotics led to a significant decrease in stool 16S rRNA and lipopolysaccharide stool (proxies for microbiome content in the stool) and altered microbiome community members; these recovered slowly. There was not a significant impact of antibiotics on influenza responses. This cohort had high baseline influenza titers, so Hagan et al. recruited a second group with 11 additional participants with low baseline influenza titers. This cohorts antibiotic-treated group again showed a decrease in microbial quantity and diversity but also showed a decrease in immunoglobulin G1 (IgG1) and IgA against one of three influenza strains. There was no clear impact on proportions of B cell subsets or T follicular helper cells. Antibiotic treatment alone yielded increases in inflammatory pathways and decreased serum secondary bile acids. Systems analysis of the entire dataset highlighted connections among the microbiome, levels of related metabolites (i.e., secondary bile acids decreased with antibiotic treatment), the subsequently increased inflammatory response (e.g., AP-1), and impact on vaccine responses. H1N1-specific IgG1 titers and secondary bile acids were both affected by the altered gut microbial community post-antibiotics, although seemingly by separate mechanisms. Continuing to delineate connections among the microbiome, metabolome, and immune response in additional, larger cohorts is fundamental to moving toward a mechanistic understanding of the impact of the microbiome on the immune system. Beyond that, given the durable impact of initial influenza exposure on subsequent influenza immune responses, it will be fascinating to study these questions in children, especially in infants before initial influenza vaccination.

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Antibiotics bug the immune response - Science

JERUSALEM, Oct. 10 (Xinhua) Israeli researchers found differences between females and males immune systems, which may explain why women are less ill than men, the Ben Gurion University (BGU) in southern Israel reported Thursday

The findings, published in the journal Nature Communications, may lead to accurate prevention, diagnosis and treatment of illnesses, with personalisation and reference to the patients gender. Men and women differ in many genetic, physiological, and social traits, but most body systems, except the reproductive system, function quite similarly.

In the study, the BGU researchers used gene expression data from 11 types of immune cells from male and female mice. Surprisingly, in one of the cell types, called macrophage, significant differences between males and females were found.

The main difference was in genes associated with interferon protein response in females, compared with males. This finding indicates some immune activity in these cells, only in females. The results suggest that the activity of the female immune system defends faster and more strongly against infectious agents.

While men tend to have infectious diseases more frequently and severely, womens immune response is stronger, and they recover better from injuries and live longer. On the other hand, this pre-activity also increases the likelihood of an over-reaction that may lead to autoimmune diseases, where immune system failure causes immune cells to attack cells in different body systems.

While All4Women endeavours to ensure health articles are based on scientific research, health articles should not be considered as a replacement for professional medical advice. Should you have concerns related to this content, it is advised that you discuss them with your personal healthcare provider.

Author: ANA Newswire

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Women have a more effective immune system than men - Research - All4Women

Flu vaccination prevents millions of flu-related illnesses and deaths annually, but vaccination rates are low for many reasons.

During the 2018-2019 flu season, the Centers for Disease Control and Prevention reported that about 45% of U.S. adults received the flu vaccine. While this is an increase of 8 percentage points from 2017-2018, it falls way below the national goal of 70% of American adults receiving a flu shot.

One of the common myths that leads people to avoid the flu shot is that they think the shot will give them the flu. But that is simply not true. The virus in the vaccine is not active, and an inactive virus cannot transmit disease. What is true is that you may feel the effects of your body mounting an immune response, but that does not mean you have the flu.

I am a nursing professor with experience in public health promotion, and I hear this and other myths often. Here are the facts and the explanations behind them.

Influenza, or the flu, is a common but serious infectious respiratory disease that can result in hospitalization or even death. The CDC estimates that during a good flu season, approximately 8% of the U.S. population could get the flu. That is roughly 26 million people.

Each year the flu season is different, and the flu virus also affects people differently. One dangerous complication of the flu is pneumonia, which can result when your body is working hard to fight the flu. This is particularly dangerous in older adults, young children and those whose immune systems arent working well, such as those receiving chemotherapy or transplant recipients.

Historically millions of Americans get the flu each year, hundreds of thousands are hospitalized and tens of thousands of people die from flu-related complications. During the 1918 flu pandemic, one-third of the worlds population, or about 500 million people, were infected with the flu. Since that time, vaccine science has dramatically changed the impact of infectious diseases.

The cornerstone of flu prevention is vaccination. The CDC recommends that everyone 6 months of age and older who does not have contraindications to the vaccine, receive the flu shot.

And just as the polio vaccine wont give a child polio, the flu vaccine will not cause the flu. Thats because the flu vaccine is made with inactive strains of the flu virus, which are not capable of causing the flu.

That said, some people may feel sick after they receive the flu shot which can lead to thinking they got sick from the shot.

However, feeling under the weather after a flu shot is actually a positive. It can be a sign that your bodys immune response is working. What happens is this: When you receive the flu shot, your body recognizes the inactive flu virus as a foreign invader. This is not dangerous; it causes your immune system to develop antibodies to attack the flu virus when exposed in the future. This natural immune response may cause some people to develop a low-grade fever, headache or overall muscle aches. These side effects can be mistaken for the flu but in reality are likely the bodys normal response to vaccination.

And the good news is these natural symptoms are short-term side effects compared to the flu, which can last much longer and is more severe. It is estimated that less than 2% of people who get a flu shot will develop a fever.

Also, people often confuse being sick with a bad cold or stomach flu with having influenza. Influenza symptoms can include a fever, chills, sore throat, runny or stuffy nose, body aches, fatigue and headaches. Cold symptoms can be similar to the flu but are typically milder. The stomach flu, or gastroenteritis, can be caused by several different bacteria or viruses. Symptoms of gastroenteritis involve nausea, vomiting and diarrhea.

Some people do get the flu after they have received a flu shot, but that is not from the shot. It can happen for a couple of reasons.

First, they could have been exposed to the flu before they had the shot. It can take up to two weeks after receiving the flu shot to develop full immunity. Therefore, if you do get the flu within this period, it is likely that you were exposed to the flu either prior to being vaccinated or before your full immunity developed.

Second, depending on the strain of the flu virus that you are exposed to, you could still get the flu even if you received the vaccine. Every year, the flu vaccine is created to best match the strain of the flu virus circulating. Therefore, the effectiveness of the flu vaccine depends on the similarity between the virus circulating in the community and the killed viruses used to make the vaccine.

If there is a close match between the two, then the effectiveness of the flu vaccine will be high. However, if there is not a close match, vaccine effectiveness could be reduced. Still, it is imperative to note that even when there is not a close match between the circulating virus and the virus used to make the vaccine, the vaccine will still lessen the severity of flu symptoms and also help prevent flu-related complications.

Bottom line: You cannot get influenza from getting the flu vaccine. As someone who has treated many people who do get the flu, I strongly urge you to get the shot.

Now read: Flu season 2019 looks bad so fight it with these 10 proven treatments

Libby Richards is an associate professor of nursing at Purdue University in West Lafayette, Ind. This was first published by The Conversation Why the flu shot cannot give you the flu (and why you should get one now)

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This claim about the flu shot is all wrong - MarketWatch

A protein associated with pregnancy is linked to disease severity and frequent exacerbations in people with bronchiectasis and chronic chest infections (that are mostly caused by Pseudomonas aeruginosa), a study suggests.

Bacteria could be hijacking a bodys natural process to shield themselves from the immune system, and persist in the airways, according to researchers at the University of Dundee. Therefore, approaches that boost the immune system could be successful against chronic respiratory infections, the team said.

The data were presented at the recent European Respiratory Society (ERS) 2019 International Congress, in Madrid, and described in the study Pregnancy Zone Protein is Associated with Airway Infection, Neutrophil Extracellular Trap Formation and Disease Severity in Bronchiectasis, which was published in the American Journal of Respiratory and Critical Care Medicine.

Pregnancy zone protein (PZP) is a powerful inhibitor of the immune system. It is produced by men and women but its blood levels are higher during pregnancy, when it is believed to suppress the immune system to protect the fetus from being rejected.

Although work in mice suggested that PZP increases susceptibility to viral infections, the protein has not been reported in the airways or studied in chronic respiratory disease.

People with chronic lung diseases are far more likely to get regular chest infections. Despite this fact, we find that the bodys normal mechanisms for dealing with infection doesnt work properly in those situations, which leaves patients trapped in a vicious cycle of coughing and spluttering from frequent chest infections, James Chalmers, PhD, professor at the University of Dundee and lead author of the study, said in a university news release, written by Grant Hill.

To investigate whether PZP could be associated with airway infections in bronchiectasis and other lung diseases, the researchers took samples from 124 people with bronchiectasis and 40 patients with chronic obstructive pulmonary disease (COPD), and analyzed the concentrations of PZP in their sputum (coughed-up mucus) and blood.

They found that PZP was present in sputum samples from people with COPD or bronchiectasis and those with chest infections, but not in healthy people.

Also, higher levels of PZP in the sputum were correlated with bacterial infections, mainly caused by P. aeruginosa.

Higher sputum PZP levels also correlated with greater disease severity, more frequent infections, reduced lung function, and quality of life as assessed by the Quality of Life Bronchiectasis Respiratory Symptom Score and with a higher amount of bacteria in the airways.

Consistent with these observations, treatment withantibiotics reduced PZP production in the airways of patients with bronchiectasis and chest infections.

A more detailed analysis revealed that a type of white blood cell, called neutrophils, was responsible for the release of PZP in the airways of patients.

In response to infections and other triggers, neutrophils launch a defense system called neutrophil extracellular traps (NETs), which can immobilize invading microorganisms. In vitro experiments showed that neutrophils alsorelease high concentrations of PZP, and confirmed the presence of this protein within NETs.

We report a novel link between airway infection, NET formation, and disease severity in bronchiectasis during chronic airway inflammation, the researchers wrote.

We were surprised to find PZP in the lungs, but this might explain why people with chronic lung disease cannot clear these infections easily. We believe that the bacteria are hijacking the bodys natural processes during pregnancy, activating the production of PZP, and shielding themselves from the immune system, Chalmers said.

These findings present a new opportunity to treat those people with the most severe types of chest infection, by kickstarting the bodys natural defense mechanisms, and helping break the vicious cycle of chest infections, he added.

Ana is a molecular biologist enthusiastic about innovation and communication. In her role as a science writer she wishes to bring the advances in medical science and technology closer to the public, particularly to those most in need of them. Ana holds a PhD in Biomedical Sciences from the University of Lisbon, Portugal, where she focused her research on molecular biology, epigenetics and infectious diseases.

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Patrcia holds her PhD in Medical Microbiology and Infectious Diseases from the Leiden University Medical Center in Leiden, The Netherlands. She has studied Applied Biology at Universidade do Minho and was a postdoctoral research fellow at Instituto de Medicina Molecular in Lisbon, Portugal. Her work has been focused on molecular genetic traits of infectious agents such as viruses and parasites.

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Bronchiectasis Severity Linked to Pregnancy-related Protein, Study Finds - Bronchiectasis News Today

Shana Tatum

By Shana Tatumstatum@wellness-collaborative.com

As we begin the fall season, pumpkin spice flavors are not the only thoughts that fill our mind. Cold and flu season may preoccupy our attention as well.

Most know the dread we feel when that scratchy throat or the drippy nose symptoms appear. It can slow us down and put a kink in our day-to-day activities. However, just as most of the points shared here in this column, there are many preventive measures to take to avoid having a season filled with colds or the flu.

If you are a regular reader of The Leader, you know I put great weight on good sleep hygiene. Practicing this nightly sets you up for a stronger immune response. In fact, recent research shows that during sleep, certain parts of the immune system are activated. One study demonstrated that people sleeping seven hours per night were shown to be 200 percent more likely to catch a cold than those who slept eight hours per night. Good, long sleep is of high importance, especially if a cold has already begun.

In addition to good rest, there are some foods that are beneficial to include in the diet to enhance the immune system.

Old-fashioned chicken soup

Its the kind our grandmothers made. Hydrating broth made with chicken bones contain amino acids rich in glycine, proline, lysine, alanine, arginine and valine. Soups like this provide needed protein and hydration during times of healing. Minerals and vitamins found in carrots, celery and onion further support the immune system in intervals of illness. Old-fashioned chicken soup also is an easily digestible soup.

Garlic

Long known for its antimicrobial properties, garlic (allicin) can help fight against infection, reduce inflammation and even may be a guard against tumor formation. Its use dates back to 400 BC and has been used by many cultures worldwide. It is a common ingredient in much of todays cooking.

It can be used minced or roasted whole in recipes for added flavor. If using garlic in your cooking is new for you or you fear the dreaded garlic breath, start slow. Add whole cloves to soups or stew-like meals. You may also find garlic in the refrigerated produce section pre-minced and in a jar.

As a health remedy, add the juice of one lime, a cup chopped onion, 1-2 cloves of minced garlic and cup water in a blender. Mix well and drink daily when cold-like symptoms appear.

Foods rich in Vitamin C

Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin. Foods high in Vitamin C act as an antioxidant to combat stress in the body. It is an immune booster and a key ingredient to include in your medicine pantry. It serves as a main structural protein of skin, cartilage and blood vessels and is rapidly depleted with physical and emotional stress.

If taken regularly before a cold strikes, it has been shown to reduce the duration of the virus.

Examples of foods rich in Vitamin C include orange and tomato juice, red bell peppers and strawberries.

Ginger

Ginger belongs to the family Zingiberaceae. Through a recent boating adventure in Kauai, I saw firsthand how ginger helps ease motion sickness. Sailors for generations have praised its properties and distant cultures have employed the root for the immune-boosting benefits. With much of the immune system housed in the digestive tract, it is no mystery that gut and immune health may both see improvements with the powerful flavorings of ginger.

An easy ginger tea can be made with boiled water, ginger root, lemons and raw honey.

Thankfully, Mother Nature provides much of the immune system support we need every day. Whether it is the powerful phytonutrients and antioxidants found in fruits and vegetables or the inflammation-reducing compounds found in herbs and spices, we can look to our daily meals to fully nourish us.

By getting good nightly sleep, avoiding excess alcohol and managing daily stress, be it physical or emotional, we can strike a balance that supports optimal wellness and keeps illness at bay. My hope is that you try some of these tips to stay well this cold and flu season.

To your health!

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How nutrition can fight colds and flu - The Leader

The writers husband with their baby girl.Creditvia Jancee Dunn

When I was pregnant, my husband and I made a habit of fondly addressing my growing belly. As obsessive first-time parents, we had read the research that bonding with your baby is linked to everything from a more robust immune system to deeper infant sleep to better cognitive and emotional development. We reasoned that it couldnt hurt to start the process while she was still in the womb. As she grew bigger, I fancied that when I talked to her, she moved around more enthusiastically. Were communicating! Already, we have a mystical connection!

I longed to meet her. I counted the days.

As is so often the case, things didnt go as planned during delivery starting with the doctors discovery that the umbilical cord had snaked around the babys neck, requiring an emergency C-section.

[Read our guide on what to expect from a Cesarean section.]

I wasnt at all prepared for the intensity of the operation the tugging, the cutting, the jets of blood onto the protective sheet. In a daze, I heard my daughter cry for the first time.

A smiling nurse materialized. Do you want to hold her? she asked.

I blinked at her. Not really, I thought. My adrenaline was surging. The brightly lit operating room was jammed with people. My body was shaking uncontrollably (a common occurrence, although researchers dont yet know the precise cause).

All I wanted to do was lurch off the operating table and hide somewhere.

I cant do it, I croaked.

The nurse nodded, and put Sylvie into the eager arms of Tom, who fell swooningly in love.

As I recovered in the hospital and then returned home, I expected that at any minute, my maternal feelings would flow, and wed resemble the enraptured moms and babies I saw in diaper cream ads.

Instead, for the first few weeks, I felt the same fuzzy disconnect as I held and fed her. When I brought this up with our pediatrician, she ran through the symptoms of postpartum depression constant crying, feelings of dark dread and hopelessness that impede your ability to care for the baby and determined I didnt have it. Still, I felt steeped in shame and guilt.

[How to recognize and seek treatment for postpartum depression]

Its time for moms to let that go, said Dr. Susan Lareau, M.D., assistant professor of obstetrics and gynecology at Magee-Womens Hospital at the University of Pittsburgh Medical Center. Some people feel an amazing, instant connection, and some think, Huh, theres a baby, she said. And thats O.K., too. We see this a lot in the hospital. Many women just need the first few hours, or days, to recover, be it a C-section or a difficult vaginal delivery. Theyre too tired to think of anything other than I want to go to sleep.

However one arrives at parenthood, from adoption to surrogacy, those feelings are normal, said Dr. Alexandra Sacks, M.D., a New York City reproductive psychiatrist. The process of becoming a mother, she said, is profound and exhilarating and triggering and a million different things that are nuanced for people.

A small but notable 2014 study published in the journal BMC Pregnancy and Childbirth revealed that distress states among new mothers feelings of detachment and the shock of the new were less severe than postpartum depression but were nonetheless difficult. In a 2018 meta-analysis, Norwegian researchers found it was common for mothers to have a gap between expectations and reality, and the sense of detachment from the child, and ensuing guilt and shame.

But the societal pressure to instantly adore your offspring is intense. Dr. Sacks ticked off a few factors that shaped my delivery room experience, among them how you relate to pain, how you relate to attachment and beginning relationships, how you experience feeling out of control, how you experience something youve never done before. Its incredibly personal.

Dr. Sacks frequently refers to the concept of matrescence, a term coined by medical anthropologist Dana Raphael in the 70s to describe the seismic shift a woman undergoes from womanhood to motherhood. Its body, mind and hormonal, with all these subcategories like sociocultural, financial, interpersonal, she said.

Katie Shea, a 32-year-old venture capitalist in Manhattan, felt this transition acutely when she had her first baby in January and didnt experience an immediate connection. I just felt very disconnected from my old me, and like I was mourning a really fun chapter of my old life, she said. My husband and I were coming from this awesome, newly married independence where we would meet each other for a drink after work to managing a new chapter in our lives that was very tactical and regimented. I felt like I was in the same room with my husband, missing my husband.

It didnt help matters that Shea was being bombarded with texts and calls from well-meaning friends, saying, Isnt this the happiest youve ever been? Theres nothing that compares to this type of love! Shea wasnt there yet: I was like, I guess, she said.

Elle Wang, 33, a partnership adviser at the United Nations in New York who lives in Long Island City, Queens, was surprised by her adjustment period when her son George was born in March, five weeks early.

Not only were she and her husband physically separated from their son in the newborn intensive care unit, which caused her tremendous anxiety, but she felt emotionally unprepared for the suddenness of his arrival.

Everything happened so quickly that I was thrown into this role immediately, said Wang, who was on maternity leave when we spoke. And it took me quite a few days to kind of come to my senses and think, This is my baby. You think its going to be this magical thing, but I think it takes people longer to really connect to the level that movies and TV shows actually project. Its not often immediate, but people dont want to admit that.

Meredith F. Small, Ph.D., a professor of anthropology at Cornell University, said that bonding is not instantaneous, but a process. Most women have a long labor, and theyre exhausted and overwhelmed, she said.

Attachment takes time, Dr. Small said, and there are many parents who do it much more slowly. You know, we believe in love at first sight but thats between two adults, and that doesnt happen very often. Attraction happens instantly, but real, deep, connected, forever love in an instant? Extraordinarily rare, she said with a laugh. And human infants are not necessarily very attractive when theyre first born.

Dr. Small added that deeper parental instincts are still at work. Chances are that the evolutionary push to protect that baby would still be there, she said. Even if you dont feel that close and youre wondering, Why is this baby here? if someone came in and tried to hurt that baby, youd have a different response.

During those first few weeks, on the advice of my pediatrician, I made skin-to-skin contact with my baby as often as possible, and I constantly carried her close to me in a sling. I gave Sylvie massages on the recommendation of a neonatal nurse, which several studies show can strengthen your connection.

Finally, while feeding her one morning, a feeling of warmth so intense it almost knocked me over engulfed me as we gazed into each others eyes.

Shea had a similar experience. A newborn might not seem to recognize us immediately, but when her daughter Lillie started smiling at four weeks, that feedback loop, that reciprocation, was my total light switch moment when I fell in love, she said.

Wang said connection wasnt instantaneous for the whole family. It took me some time. It took my husband some time. It took the baby himself some time! The baby needs a moment, too. And I think if we have an honest conversation about it, it can save some people heartache.

So, ditch the guilt. A heartening new Lehigh University study found that when caregivers respond to their babys need for attention, they need only to get it right half the time to provide a secure base for baby. As study author Susan S. Woodhouse, an infant researcher, put it, You dont have to be perfect, you just have to be good enough.

Theres no lost time, said Dr. Sacks. Those first few moments, or days, are not paramount in your relationship with your child. Your relationship is about a much larger story than a few days.

Jancee Dunn is the author of How Not To Hate Your Husband After Kids.

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I Didn't Bond With My Baby Right Away - NYT Parenting

Cancer myths irritate me. Not only because they fly in the face of scientific research, but also because they prey upon people who are just trying to do their best to live a healthy life.

These myths start to get especially dangerous when they might affect someones response to a cancer diagnosis, so I reached out to some researchers at the ICR to find out which myths bug them the most. Here are the top 13:

There are many types of cancer which you are more likely to develop if someone in your family has had them, but a very small number of cancers are inherited. There is lots of research looking into genes which might identify those at higher risk of developing cancer, and whether this risk affects other people in the family.

But the overwhelming majority of cancers are caused by changes to your DNA that happen over the course of your lifetime, in response to changes in your environment or the ageing process.

Cancer is easy to kill. If you put some cancer cells in a dish and pour some bleach on them, they wont survive for very long. Pouring bleach on some bacteria growing in a petri dish would have much the same effect, but we dont take bleach when we have an infection, for the same reason we dont take it when we have cancer.

The reason finding cancer treatments is so hard is because cancer cells are just normal cells which have turned malignant. Anything that kills a cancer cell is therefore likely to kill your own healthy cells as well. The ideal cancer drug is selectively toxic it will only harm the cancer cells and leave your own cells unscathed.

While older chemotherapy treatments are famously difficult for patients and come with a whole host of nasty side effects, modern research is focused on developing smarter, kinder treatments.

Many of these treatments focus on training your immune system to spot cancer cells and fight them, or therapies which target the genesthat have caused the cancer in the first place.

While some older cancer treatments may not be as kind as more modern therapies, they dont make cancer worse.

Cancer is very much a real disease. Theres not a whole lot else to say on this one. Watch this video of a patient affected by the ICR's research:

The theory behind this myth is that excessive exposure to radiofrequency energy from cellular phones causes cancer. The basic cause of cancer is damage to your DNA, a discovery that was made at the ICR.

But there is no evidence that radiofrequency waves cause DNA damage, which is what leads to cells becoming cancerous, so the pylons/mobile phone myth simply doesnt add up. Radiofrequency waves are nowhere near as strong as other types of radiation like x-rays or UV, which can break the chemical bonds in DNA.

If youve ever heard someone suggest that childhood leukaemia is caused by radiowaves or pollution, Professor Mel Greaveshas published research which shows that there is a clear, biological cause of the disease.

You can read more from Professor Greavesin this blog post which tackles more myths about the causes of leukaemia.

Not dissimilar to the mobile phones myth above, this one stems from a belief that the radiofrequency waves in microwaves can somehow increase the incidence of cancer.

But just like mobile phones, the radiofrequency waves are much too low in energy to cause the damage to DNA which leads to cancer.

Vaccines prevent disease by exposing the immune system to small, often inactive, amounts of infectious material that help it recognise the real disease when it comes along.

There is no link between vaccines and an increased risk of cancer. Cancer patients cant receive vaccines when undergoing treatment, since their immune systems are usually weakened by these therapies and vaccines require someone to have a functioning immune system in order to work properly.

There are actually two vaccines which can protect against cancer the HPV and HBV vaccines. The HPV vaccines prevents against the Human Papilloma Virus, which is linked to cervical, anal, throat and other cancers. The HBV vaccines protects against the hepatitis B virus, which can cause longterm damage to the liver and increase the risk of liver cancer.

Some people think that its possible for an injury to cause cancer you may have heard anecdotes about someone being involved in a car accident who later goes on to be diagnosed with cancer.

Injuries often require thorough medical examinations including imaging like x-rays and MRIs, and these scans can reveal cancers which were already present before the accident happened.

So while it might seem like the two are related, they usually arent. Some types of cancer, like myeloma, can also cause weaknesses in bones, making them more likely to break, or increase your likelihood of severe bruising, which may lead you to see your doctor who then go on to spot the cancer.

This myth is incredibly pervasive, to the point that some people have 'alkylisers' installed on their kitchen sinks in the hope that drinking alkaline water will reduce their risk of developing cancer.

The story goes that cancer can only grow in an acidic environment, so by eating alkaline foods, you can change your bodys pH and thereby eliminate your risk of cancer.

Except that you cant.

The tumour microenvironment which is the area of cells and tissues that directly surrounds a tumour tends to be acidic. Each organ and tissue in your body has its own optimum pH range in which it functions best, and your body has incredibly tightly regulated systems to make sure the pH never goes outside of this range.

You cannot change the pH of your body by eating alkaline foods. The first place anything you consume goes is your stomach, which is a nice big bath of pH 2 hydrochloric acid.

Yes they do. Sharks get cancer at a rate much lower than humans, but they do still get the disease.

This myth is one of those pervasive ones that is repeated by all kinds of people and the general idea seems to be that if sharks dont get cancer, there might be something about them which holds the key to curing or preventing the disease in humans.

There is some evidence that cartilage is antiangiogenic this means that it prevents the development of blood vessels. Cancer needs blood vessels to be able to grow and thrive, so the theory goes that if sharks are made of mostly cartilage, they wont have the kinds of bodies that can support the growth of tumours.

Its an oversimplification, and sharks do get cancer.

We can learn lots about cancer by studying which animals get it and how it develops you can read more about that in this blog post.

No, you dont need to clean your glasses, you did read that correctly. You may not have heard about vitamin B17 and thats becauseit doesnt exist.

Vitamin B17, also called laetrile, is touted as an alternative therapy for cancer, but there is no evidence that it works. Its a manmade version of a chemical found in lots of different plants, and it contains cyanide.

There is no reliable evidence that it works as a cancer treatment or as a treatment for anything else. Its not available for sale in the UK or Europe, due to lack of evidence of its effectiveness.

If there is, wed love to hear about it! The big issue with this myth is of course the notion that cancer is one disease, and it can be cured by any one drug or treatment. The reality is that cancer is an incredibly complex and varied disease. It always has its basis in genetics, but there is a world of a difference between rhabdomyoscaroma and neuroblastoma.

Categorising cancers into groups which have common characteristics helps researchers know where to focus, and helps clinicians know which treatments are likely to be most effective.

So there is no one cure for cancer, because cancer is not one disease.

While eating a healthy, balanced diet with plenty of fruit and vegetables is important to maintain good overall healthand has been linked with reduced cancer risk, no particular food item can be singled out as having a significant impact in either preventing or treating cancer.

News headlines occasionally report that 'X food fights cancer' but these are usually extrapolations of the real research.

While I do love the idea of scientists shooting blueberries out of a cannon at cancer cells growing in a dish, the reality is usually that one single chemical compound from one type of plant is methodically tested to assess its ability to selectively kill cancer cells, and the research is then published in the academic literature.

Not as jazzy, but still very important work!

Sadly, there is still a long way to go when it comes to improving cancer treatments, and its a myth that we wont still lose people to the disease. Scientists and clinicians are making leaps and bounds when it comes to researching cancer, its causes and potential solutions to fight it.

The ICRs new Centre for Cancer Drug Discoverywill focus on trying to outsmart cancer as the disease evolves to adapt to the latest treatments, and the pace of developments in artificial intelligence means were always taking steps forward in beating the disease.

Ill be taking about 30,000 steps forward on 13 October in the Royal Parks Half Marathonto raise funds for the ICR and Ill be keeping the devastating truths of cancer in my mind every step of the way.

To support Joanne and donate to the ICR, please visit her fundraising page:

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Science Talk - Debunking 13 common cancer myths - The Institute of Cancer Research, London - The Institute of Cancer Research

At the British Neuroscience Association (BNA)s Festival of Neuroscience in April 2019, we were lucky enough to sit down with some influential neuroscientists to discuss their work. Weve assembled these transcripts into our BNA Interview Series. Here, in our final interview of the series, we talk to Professor Ed Bullmore, who splits his time between academic research at the University of Cambridge and industry research with GSK. Professor Bullmore was at the conference outlining some of the evidence that connects inflammation and depression, and the possibility that the immune system could be targeted as part of future antidepressant treatments.Ruairi Mackenzie (RM): Could you outline the link between inflammation and depression?

Ed Bullmore (EB):Well I think the first thing to say is that inflammation and depression go together, so they co-occur; theyre correlated with each other. That, I would say, is beyond reasonable doubt. You can look at two kinds of evidence for that association. You can look at people who have an inflamed body, who have a major medical inflammatory disorder like arthritis or psoriasis or inflammatory bowel disease and ask the question, is that associated with an increased risk of depression? And it is, very robustly. You can also go to people who have depression but dont have an obvious medical inflammatory disease, you can take a blood test and you can measure the inflammatory state of the immune system in a more sensitive way and you can show a very consistent trend and people have shown this over multiple years and multiple studies that on average, people with depression have slightly but significantly increased levels of inflammatory proteins in circulation compared to healthy controls. So, those two bits of evidence I think put it beyond reasonable doubt that there is an association. The question then is about causation. What drives that association and what is the evidence that inflammation and depression are not just kind of going together but one is driving the other, particularly inflammation driving depression.RM: Whatisthe evidence that inflammation is the driving factor behind depression?

EB:There is a lot of evidence from animal studies. If you make an animal inflamed, you will change its behavior so that it looks as if it might be depressed. You can change their social behavior, their interaction with other animals, they are less likely to drink sweetened water, more likely to drink plain water as if they have lost the capacity for pleasure. There are various other sleep and behavioral changes that you can see in animals that look depressed but perhaps the most convincing evidence comes from studies in humans and one thing that you would predict, if inflammation caused depression, then you might expect to find examples of inflammation preceding or anticipating depression because cause precedes effect. If you look, there is evidence for that too.So if you look at long term follow up studies, epidemiological studies, it has been shown that if you are inflamed but not depressed at one point in time then over follow up you are more likely to be depressed than the people that were not inflamed originally. So theres that kind of evidence. You can see in patients, for example, that have got hepatitis, a viral infection of the liver, if you give them an inflammatory treatment to cure their hepatitis, about a third of them will become depressed.RM: Really? Thats really fascinating, that last piece of evidence. Do you see that over time that if their inflammation goes away for whatever reason, they are less likely to become depressed?

EB:Im not sure that thats been so certainly studied, but what I think is pretty clear is that inflammation can precede depression and that, I would say, is a necessary condition for inflammation to be causal.RM: Depression is an immensely complex condition so different risk factors will have different contributions. Are there any firm numbers on what is the significance of this contribution to depression versus other factors?

EB:Well I think its very important, as your questions is suggesting, were not talking about inflammation explaining every case or experience of depression, but based on blood test measurements, it looks like about a third of people with major depressive disorder might also be inflamed and then you think about all the people with so-called comorbid depression, people with arthritis, inflammatory bowel disease. In rheumatoid arthritis, for example, about 25% of those patients are significantly depressed. So, its quite a big chunk of people. Its not everybody, but its a lot of people, I think.RM: Rheumatoid arthritis and some other conditions which involve chronic inflammation, they dont just impact our bodies but also our social lives. It might make it harder for people to leave the house and socialize with friends and obviously social isolation is also a risk factor of depression. Are there studies or have there been observations made that isolate the two?

EB:No, is the short answer. I mean, I think particularly depression, fatigue and other psychological symptoms have been woefully under investigated, in my opinion, in arthritis and other medical conditions. We need to do much more. The traditional explanation is more what you might call a sociological explanation. Youre depressed because youre thinking about arthritis, because of the impact that it has on your life. It might make it more difficult for you to interact with friends, you may feel gloomy about what the future holds. Are you going to end up in a wheelchair? How is it going to impact on your mobility in the long term? Thats the traditional explanation, and I wouldnt claim that those psychological mechanisms are not at all relevant to the link between depression, arthritis or other inflammatory diseases but I think its important that we allow the possibility that there could be other explanations. There could be a more direct mechanistic link between the autoimmune disease, the inflammatory disease and the body in these patients and their altered mental state.RM: Have there been studies into immunocompromised populations; are they less likely to become depressed?

EB:Its an interesting idea. No, Im not aware that there have been studies looking at immunodeficiencies. I would say there is an opportunity for a lot more work to be done at the interface between mind and body, particularly in what you might traditionally regard as non-psychiatric disorders, and that could include immunodeficiency syndromes as well as autoimmune disorders like arthritis.RM: Are these inflammatory effects isolated to just depression or are there other conditions that are associated?

EB:I think the existing evidence is strongest for depression but if you delve into the literature there is quite a strong story about psychosis in some cases, psychosis being associated with a different kind of abnormality of the immune system. There is a small percentage of patients with a first episode of psychosis who have high levels of autoantibodies. Antibodies that are directed against the bodys own proteins, particularly the glutamate receptor. The anti-NMDA antibody is associated with psychosis and thats an interesting story that people are exploring. I think the other area where there is a lot of interest is neurodegeneration, Alzheimers disease, for example. People are increasingly interested in the idea that when the plaques and tangles of amyloid and tau protein form in the brain, maybe the immune system sees those abnormal proteins as if they were germs, as if they were antigens, and that stimulates an immune response, an inflammatory reaction in the brain which could be damaging to nerve cells and could contribute to neuronal loss and psychological deterioration. So, a lot of companies are interested, I think, in developing new anti-inflammatory treatments to arrest the rate of progression in neurodegenerative disorders.RM: Do these studies look at immune populations specifically within the brain or in the rest of the body as well?

EB:Well its much, much easier to look at the immune system in the rest of the body than the brain. You can get a pretty good read on the immune system from a blood sample but that doesnt tell you anything about the microglial (immune cells resident within the brain) status, for example. I think its one of the key challenges for the field is to develop better biomarkers of brain inflammation. We have very limited options now. You can take a cerebrospinal fluid (CSF) sample and you can measure inflammatory proteins and a few immune cells in a CSF sample but a lot of patients with depression arent going to go along with that. What else have we got? Well you can use various imaging techniques, structural MRI, functional MRI. There are changes in those markers associated with altered levels of peripheral inflammation but the signal itself is not very specific to the immune system. The most promising approach I think, is going to be developments using positron emotional tomography (PET) where you can get a tracer into the blood that will bind to a specific target in the brain and there has been quite a lot of work looking at PET markers that allegedly are specific to microglial activation which have shown increases in Alzheimers disease and also in depression. If you talk to people in the field, I think everybody agrees that the existing PET traces of brain inflammation are better than nothing, but theyre not as specific or sensitive as we want them to be. So I think thats an area where I will hope to see progress over the next few years, is development of better neuroimaging tools for central inflammation.RM: Thinking about the next few years, as a final question, what do you think the future of depression treatment looks like?

EB:Well, what I really hope is that we get away from this idea that depression is just one thing, that everybody is depressed for the same reason and that one day there will be a panacea. That there will be a drug or a psychological intervention thats going to make everybody happy, cure depression for everybody. I think thats been the mindset for a lot of drug development in the past and I think we need to move on from that. Psychiatry, I hope, will catch up with the rest of medicine. The rest of medicine doesnt treat symptoms as if they are all the same, the rest of medicine looks for the causes of symptoms and it tries to treat those causes. So my hope for the future of depression is that we will get to a place where we are beginning to identify causes, we are beginning to get cleverer about identifying which patients are depressed for which particular reason and more precisely targeting treatments to the individuals most likely to respond because their depression is caused by some factor that is responsive to the treatment in question. That kind of more personalized, precise approach is, I hope, where we will get to.RM: Will this strategy involve just pharmacological interventions or also other therapies?

EB: Absolutely, I think thats a very important point. You know, as you have mentioned I work also at GSK and come at this really from the point of view of wondering whether, by focusing on the immune system, could we find the next generation of antidepressant drugs, but the science of neuroimmunology, the interaction between the brain and the immune system, I dont think means that the treatments have to be pharmacological. I think there is a lot of interest in vagal nerve stimulation as a treatment for depression. We know that vagal nerve stimulation often has anti-inflammatory effects. There is a little bit of work in the literature there could be more showing that, for example, meditation has anti-inflammatory effects and so there are a lot of ways in which the immune system could be dampened down or controlled. Diet is another obvious example a lot of inflammation might have its origin in the microbiome could you be effective with a dietary regime change that might alter the microbiome, make it less provocative to the immune system? I think these are all hopes for the future.

Professor Ed Bullmore was speaking to Ruairi J Mackenzie, Science Writer for Technology Networks. Interviews have been edited for length and clarity.

Excerpt from:
BNA Interview Series: Exploring the Inflamed Mind With Professor Ed Bullmore - Technology Networks

Kaitlin A. Davis and Andrew Mehle discuss the research and context behind the new PLOS Pathogens Pearls article, Does rotavirus turn on type 1 diabetes?.

There is a growing appreciation that viral infections can have long lasting impacts, well after the original infection has been cleared. One example is the proposed connection between childhood infections with rotavirus and the subsequent development of type 1 diabetes. As highlighted in a PLOS Pathogens Pearls article this month, new evidence supports this correlation and suggests that vaccination against rotavirus may contribute to a global decrease in type 1 diabetes prevalence among young children. This surprising effect of vaccination could be the first example of primary prevention of type 1 diabetes, something not currently possible.

Rotavirus, a member of the Reoviridae family, is a major cause of infantile diarrheal disease worldwide, accounting for over 215,000 deaths annually. In a powerful demonstration of the positive effects of public health campaigns, mortality associated with rotavirus infection has substantially decreased since the introduction of rotavirus vaccines. Now, multiple studies have described an associated decrease in type 1 diabetes incidence following vaccination.

How might rotavirus infection be tied to the development of type 1 diabetes? Type 1 diabetesis an autoimmune condition characterized by the destruction of beta cells in the pancreas by the bodys own immune system, leading to the functional absence of insulin While there are some genetic determinants of type 1 diabetes, the precise triggers of this autoimmune disease are not fully understood. Interestingly, portions of proteins on the surface of beta cells that are recognized by T cells the killers of the immune system are strikingly similar to a rotavirus capsid protein called VP7. Both the beta cell protein and its viral doppelganger VP7 are able to stimulate similar T cell responses, and this response can be observed in both humans and animals following infection and vaccination. Previous studies have directly linked rotavirus infection to the production of antibodies associated with diabetes in young children, and similarly, infections in mice have been linked to pancreatic cell death and hyperglycemia. Perhaps rotavirus infection trains the immune system to accidentally target beta cells.

Rotarix [GSK] and RotaTeq [Merck] are the most routinely used rotavirus vaccines, administered in the first six months of life. These vaccines include HLA-mimic VP7 sequences and were fully introduced to communities worldwide from 2006-2008. In studies from both Australia and the United States spanning this time period, type 1 diabetes prevalence decreased coincident with vaccine introduction. In Australia, reported by Perrett, et al., the number of new cases of type 1 diabetes among children 0-4 years of age decreased by 15% following the introduction of rotavirus vaccines. Excitingly, this finding was recapitulated in an American cohort, where a 33-37% reduction in the risk of type 1 diabetes was observed following completion of a rotavirus vaccine series. Thus, if rotavirus infection is a trigger for the development of type 1 diabetes, preventing infections by vaccination would not only reduce viral disease, but have the added benefit of reducing type 1 diabetes. This is exactly what is reported in these new studies and summarized in the PLOS Pathogens Pearls article.

While trends are common between these two diverse studies, there are likely additional factors that contribute to protection. An analysis of a Finnish cohort reports that associations between rotavirus vaccination and type 1 diabetes incidence were inconclusive. This may in part be due to sample size variability between the studies, but also highlights the role of geographical and environmental differences in immunity. Rotavirus mortality and vaccine efficacy are known to vary significantly by country and environment, and similarly, factors promoting type 1 diabetes incidence are likely to be diverse. If the associations outlined in these studies hold true for multiple groups and persist as children age, these findings could outline at least one ubiquitous factor that affects type 1 diabetes development worldwide.

About the Authors

Kaitlin A. Davis received her PhD in Biology from Johns Hopkins University, under the mentorship of Dr. John T. Patton, where she studied mechanisms of rotavirus immune evasion and antagonism. She is currently a postdoctoral research associate with Andrew Mehle at the University of Wisconsin Madison studying how ADP-ribosylation of influenza virus proteins regulates viral replication processes. She also serves on the American Society for Virology executive council.

Andrew Mehle received his PhD in Virology at Harvard University training with Dr. Dana Gabuzda to study virus:host interactions during HIV infection. He continued with postdoctoral training at the University of California Berkeley in the lab of Dr. Jennifer Doudna where his focus shifted to influenza virus. He established his own lab at the University of Wisconsin Madison in 2011 (mehlelab.com), where he is currently an Associate Professor in the Department of Medical Microbiology and Immunology and holds an Investigators in the Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund.

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More benefits to vaccination: rotavirus vaccines reduce the incidence of type-1 diabetes | Speaking of Medicine - PLoS Blogs

As most dog owners will attest, four-legged canine companions generate boundless love and joy through their playful antics and tail-wagging devotion.

Accordingly, much research finds they can improve mental health - and now, evidence for their tangible physical health benefits is growing.

A Swedish study and separate meta-analysis, published in the journal Circulation, found that dog owners live longer and do better after having a heart attack or stroke.

First, the Swedes compared the health outcomes of 182,000 people with and without dogs after a heart attack and 155,000 people after a stroke, using health data recorded by the Swedish National Patient Register between 2001 and 2012.

The largest differences between dog owners and non-owners were seen in single households.

After adjusting for demographic and socioeconomic factors, they found that dog owners who lived alone had 33% lower risk of death after a heart attack and 27% less chance of death after a stroke. The effect was not quite as pronounced for people living with a partner or child, with 15% and 12% lower risk, respectively.

Although the mechanisms cant be confirmed with the observational study design, senior author Tove Fall from Uppsala University in Sweden says he was surprised at the large differences in the outcomes, and thinks its likely that exercise and companionship factor in.

We know that dogs can be a good motivator for physical activity, he says. We also know that physical activity and social support are important for optimal recovery after a major cardiovascular event.

Meanwhile, clinician and research scientist Caroline Kramer, from Mt Sinai Hospital in Toronto, Canada, was curious about research showing the benefits of dog ownership in her pursuit of lifestyle changes that can promote peoples health.

What really sparked it, she admits, was her dog a miniature Schnauzer called Romeo.

Since I adopted him, she says, I got more active, and the daily routine with a dog companion is a joy. So when I saw a research report on that I was curious and decided to research further.

The result was a systematic review and meta-analysis of the association between dog ownership and death from all causes or heart disease.

The composite analysis included 10 studies with data from 3.8 million patients and follow-ups ranging from one to 22 years. Overall, having a dog prolonged survival, reducing risk of death by 24%.

When it came to heart attacks and other heart-related issues, dog owners had a 65% and 31% lower risk of death, respectively.

The research builds upon prior findings and conclusions of the American Heart Association (AHA)s scientific statement that dog ownership is associated with lower risk factors for heart disease, such as high blood pressure and blood lipid levels, says Glenn Levine, chair of the statements writing group.

Further, these two studies provide good, quality data indicating dog ownership is associated with reduced cardiac and all-cause mortality, he adds.

While these non-randomised controlled studies cannot prove that adopting or owning a dog directly leads to reduced mortality, those robust findings are certainly at least suggestive of this.

In a related editorial, Who is rescuing whom?, Dhruv Kazi, from Harvard Medical School, Boston, notes that pet owners tend to have other heart-health promoting features. These include being younger, better educated, wealthier and more likely to be married. Its also possible that healthier people are more able to adopt a dog.

However, he remarks that its plausible they improve peoples health, given that dog ownership prompts more time being active outdoors. He also notes evidence that the rich variety of germs they bring into the home can positively alter peoples gut microbiome.

He agrees with the AHA, though, that medical reasons alone should not the driving motivator to get a dog, as its a much larger undertaking than embarking on a new medical therapy, involving significant commitment and lifestyle changes.

Quoting Pulitzer-Prize winning poet Mary Oliver, he concludes that the real reward of dog ownership is that there can hardly be a sweeter arrangement than the unconditional love of a loyal friend.

The health benefits of dog ownership are a welcome and possibly substantial bonus.

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Canine pals could be the secret to longevity - Cosmos

The discovery in the 1990s that a mutation in a single gene of an experimental worm could double its lifespan set off a stampede of research on the molecular biology of aging and triggered hopes that drug therapies or other interventions could be developed to extend healthy human lifespan. But as is often the case in science, the genetic regulation of aging is more complicated than it first appeared.

The nature of this complexity is illuminated in a new paper byMDI Biological LaboratoryscientistsJarod Rollins, Ph.D., andAric Rogers, Ph.D., co-corresponding authors, which describes the mechanisms by which longevity is regulated post-transcriptionally, or after a genetic blueprint has been transcribed from an organism's DNA. The identification of these mechanisms will serve as a road map for screening new, more specific drugs to prolong healthy lifespan.

The research was conducted inC. elegans, a tiny nematode worm that is a popular model in aging research because of its genetic similarity to humans and because of its short lifespan, which allows scientists to easily study lifespan-extending interventions.

"The MDI Biological Laboratory is deeply committed to translational research, or research that can be translated into therapies to improve human health in our focus areas of regeneration and aging," saidHermann Haller, M.D., president. "Because it identifies new potential drug targets in the form of the post-transcriptional mechanisms governing longevity, this research will be hugely important in screening for new therapies to extend healthy human lifespan."

The paper, "Dietary Restriction Induces Post-transcriptional Regulation of Longevity Genes," which was recently published in the journalLife Science Alliance, is the product of five years of research in the Rollins and Rogers laboratories at the MDI Biological Laboratory.

The scientists used bioinformatics, or data analysis, techniques to compare genes in worms fed normal diets with those whose diets were restricted.Dietary restriction, or DR, which refers to calorie restriction without malnutrition, is the most robust intervention known for extending lifespan, and has been demonstrated to increase lifespan and delay the onset of age-related degenerative disease in a wide range of species, from one-celled yeasts to primates.

The scientific evidence on the lifespan-prolonging effects of DR has ignited a quest to develop "DR mimetics," or drugs that mimic the effects of DR without the need to dramatically reduce calories. In addition to being difficult to adhere to, such a diet is associated with negative side effects including increased sensitivity to cold and loss of energy and libido. The identification of these new mechanisms opens up the possibility of developing new, more precise DR mimetics.

"Science already knows a lot about how longevity is regulated at the genetic level, but the picture isn't complete if we just look at transcription," Rollins said. "With this research, we are drilling down to additional layers of regulation, which brings us one step closer to extending healthy human lifespan without the need to dramatically restrict calories or to take drugs that, because they are less selectively targeted, are more likely to cause adverse reactions."

The goal of DR mimetics is to access the adaptive programs in the cell that are activated when an organism is exposed to an existential threat such as a scarcity of nutrients. In such a case, the cellular machinery shifts from an emphasis on growth and reproduction, which is costly in terms of cellular resources, to an emphasis on survival. In order to ensure that an organism survives to reproduce when conditions improve, nature seeks to ensure that its cells function at peak efficiency.

In addition to confirming existing theories about the adaptive response to DR, the paper highlights the importance of post-transcriptional regulation -- or regulation that occurs after a gene has been "read" or "transcribed" from the DNA in the nucleus of the cell. The identification of the mechanisms that govern post-transcriptional levels of gene expression charts a pathway for screening, or testing, drugs that may have pro-longevity effects.

"We found that hundreds of genes are being regulated almost solely at the post-transcriptional level," Rollins said. "These are genes that weren't previously known to have a role in longevity. This level of regulation can be missed if scientists are looking at the transcriptional level alone. The identification of these mechanisms gives us a better idea of how DR works and opens up a whole new area of potential investigation for the aging biology community."

Reference: Rollins et al. 2019.Dietary restriction induces posttranscriptional regulation of longevity genes. Life Science Alliance. DOI: 10.26508/lsa.201800281.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Decoding the Genetic Mechanisms of Aging - Technology Networks

The longevity of 'Little Women'

Visit the house where Louisa May Alcott wrote 'Little Women' 150 years ago

Updated: 8:10 PM EDT Oct 4, 2019

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ANTHONY: A GRAND CELEBRATION CALLS FOR A FRESH COAT OF PAINT AT THIS ORCHARD HOUSE IN CONCORD. 2018 MARKED THE SESQUICENTENNIAL OF THE PUBLISHING -- PUBLICATION OF LITTLE WOMEN. >> I AM REREADING IT WITH MY BEST FRIEND. IT WAS NEAT BEING ABLE TO COME AND SEE THE HOUSE. ANTHONY: WRITTEN HERE 150 YEARS AGO, NEVER OUT-OF-PRINT, TRANSLATED INTO 50 LANGUAGES. HOLLYWOOD HAS MADE ANOTHER MOVIE OF THE CLASSIC. THIS ONE DIRECTED BY OSCAR NOMINATED GRETA GERWIG. >> GRETA GERWIG AND THE ACTRESSES HAVE COME THROUGH MULTIPLE TIMES ASKING QUESTIONS, WANTING TO ABSORB THE HOUSE. THEY WANTED THE EXACT RANGE COLOR. THEY HAVE BEEN PASSIONATE ABOUT GETTING IT RIGHT. ANTHONY: THERE IS NO SHORTAGE OF PASSION FOR ORCHARD HOUSE, SAYS EXECUTIVE DIRECTOR JAN TURNQUIST . VISITORS FROM AROUND THE WORLD FIND THEIR WAY HERE. >> IT SEEMS TO SPEAK TO THE HEART OF SO MANY READERS, THE MATTER WHAT THEIR CULTURE. THE FACT YOU CAN COME INTO THE ROOMS AND FEEL AS IF THE FAMILY HAS JUST LEFT A MOMENT AGO, IT IS AS CLOSE AS THEY CAN COME TO MEETING THE AUTHOR. ANTHONY: MOST NOTABLE IS LOUISAS WRITING DESK. >> BRONSON AND ABIGAIL GOT -- THEY FELT THEIR DAUGHTERS SHOULD FILL THEIR OWN DESTINY. A DESK OF HER OWN IN ANOTHER EMILY WOULD HAVE BEEN CONSIDERED FOR BITTEN. PHYSICIANS HAD PROVED SUPPOSEDLY BRAINWORK LIKE WRITING WOULD DESTROY A WOMANS HEALTH. THEY THOUGHT IT WAS RIDICULOUS. BRONSON BUILT LOUISA THE DESK AND MRS. ELLICOTT GAVE HER A PEN. THE MAVIS PENN USED TO INSPIRE WHEN WRAPPED IN -- [INDISCERNIBLE] ANTHONY: THE EDUCATOR FOUNDED THE CONCORD SCHOOL OF PHILOSOPHY AND LITERATURE IN HIS STUDY. HE BUILT A LECTURE HALL OUTSIDE. THE SCHOOL IS SLATED FOR ITS HOLLYWOOD DEBUT. >> THE MAKERS OF THIS MOVIE WANTED SO MUCH TO DO SOME OF THE FILMING HERE AT THE SCHOOL. THEY THOUGHT IT WOULD WORK FOR THE SCENE WHEN AMY MARCH BRINGS PICKLE BLINDS TO SCHOOL. ANTHONY: 150 YEARS AND STILL GOING STRONG. WHAT WOULD LOUISA MAKE OF ALL THE FUSS. >> SHE WOULD COMPLETELY ASTONISHED IT COULD CONTINUE LONG AFTER THE PUBLICATION OF HER BOOK. 150 YEARS. SHE WOULD BE AMUSED, PLEASED AND MOSTLY AMAZED. ANTHONY: ALL OF THE ABOVE. LITTLE WOMEN CHRISTMAS DAY. SHAYNA: THAT IS CHRONICLE FOR TODAY. THANK YOU FOR JOINING US. I AM SHAYNA SEYMOUR. ANTH

The longevity of 'Little Women'

Visit the house where Louisa May Alcott wrote 'Little Women' 150 years ago

Updated: 8:10 PM EDT Oct 4, 2019

2018 marked the sesquicentennial of the publication of "Little Women." Written in Concord at Orchard House 150 years ago, it never went out of print and has been translated into 50 languages. It is so tried and true, Hollywood has made yet another movie of the classic, this one directed by Oscar-nominated Greta Gerwig.

2018 marked the sesquicentennial of the publication of "Little Women." Written in Concord at Orchard House 150 years ago, it never went out of print and has been translated into 50 languages. It is so tried and true, Hollywood has made yet another movie of the classic, this one directed by Oscar-nominated Greta Gerwig.

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The longevity of 'Little Women' - WCVB Boston

The records state that Lordi formed in 1992 and released their first album in 2002, but what if they actually had been around much longer? That's a bit of the idea behind their latest album, Killection.

According to the press announcement for the new album, the group has envisioned the release as if they had actually been around making music since the early '70s, with this selection of songs spanning that entire era.

"Killection is a compilation album that simply says what if Lordi had been in existence since the early 70's. It contains all their imaginary hit singles from different periods done with painstaking attention to detail using authentic studios and vintage technology. This is how they would have sounded if Lordi would have made music back then and therefore would have had the hit material to release this compilation now," reads a description for the album.

Mr. Lordi himself adds, "Killection is a fictional compilation album. It contains songs that Lordi would have written between the early 70's through the mid-90's. The compilation contains one "brand new" song from 2019 as well, cause thats somehow always typical for compilations."

Killection is due Jan. 31 and you can check out the artwork and track listing below. At present, they have a one-off in Helsinki, Finland on Dec. 13, but will return to the road in earnest in February for a month-and-a-half long European tour. See all their dates here.

Lordi, Killection Artwork + Track Listing

01 Radio SCG 1002 Horror for Hire03 Shake the Baby Silent04 Like a Bee to the Honey05 Apollyon06 SCG10 the Last Hour07 Blow My Fuse08 I Dug a Hole in the Yard For You09 Zombimbo10 Up To No Good11 SCG10 Demonic Semitones12 Cutterfly13 Evil14 Scream Demon15 SCG10 I Am Here

10 Best Masked Rock + Metal Acts

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Lordi Envision Greater Longevity With 'Killection' Album - Loudwire

In the US, the average life expectancy is 78 years. But there are a few places in the worldspecifically Okinawa, Japan; Sardinia, Italy; Nicoya, Costa Rica; and Icaria, Greecewhere living to be over 100 isnt uncommon at all. In these regions, known as Blue Zones, the life expectancy isnt just higher; centenarians are generally also healthy, their minds and bodies still working well.

National Geographic journalist Dan Buettner spent years studying each culture, pinpointing the exact reasons why they thrived before publishing his findings in the best selling book, The Blue Zones: Lessons for Living Longer From the People Whove Lived the Longest.Buettner found that despite the geographical differences, people living in the Blue Zones all had nine key lifestyle habits in common, which he named the Power 9. Here, each pillar is explained, with input from doctors about why its so crucially connected to health and longevity. Keep reading for the complete intel, including how to apply the pillars to your own life.

Buettner found that in all the Blue Zones communities, movement was a regular part of daily life for the residents. The Longevity Plan author John Day, MD saw this first-hand as well when he spent a year living in remote China. Even in their advanced age, he saw centenarians working in the fields and throughout the village.

Of course, here in the States, our jobs are a lot more sedentary. But Dr. Day still says we can work this pillar into everyday life. Unfortunately, our modern lifestyles have been engineered in a way to take movement out of our lives, so it is up to us to get in as much as we can during the day, he says. For example, you could take a vow to never use an elevator or escalator again unless the stairs are restricted. Other options include an evening walk or doing everything possible to avoid having to use a car. Even vacations can be scheduled in a way that are physically active, like a vacation centered around skiing, hiking, or cycling.

Richard Honaker, MD, who works with Your Doctors Online, echoes this saying, The more exercise you can fit into your day, the better. Even walking is good for your health. His recommendation is to aim for a minimum of 30 minutes of exercise three times a week. This is the bare minimum amount of exercise to do that will benefit your health, he says.

Having a clear sense of why you wake up in the morning is connected to living a long, healthy life. Purpose is related to happiness, and happiness is associated with better health than sadness or indifference, Dr. Honaker says.

Dr. Day adds that the connection between the mind, health, and a sense of purpose is powerful. Whether your goal is to beat cardiovascular disease or cancer, or even to live a long and healthy life, study after study has found an association of purpose in life with all kinds of better health outcomesan effect that stands regardless of age, sex, education or race, he says. You have to have a reason to get out of bed every morning. Something that pushes and motivates you. For without purpose it is next to impossible to maintain the healthy behaviors and lifestyle that is conducive to a long and healthy life.

PSA: Chronic stress is terrible for your health, which is why stress management is one of the pillars for living a long, healthy life. We all have stress. The key is how you perceive your stress, Dr. Day says. If you view stress as something that is making you stronger or refining you then it can be a good thing. If you view stress as something destructive then it probably is.

During his time in China, he saw that simple lifestyle habits such as eating nourishing foods, being physically active, getting good sleep, and socializing with family and neighbors all helped negate the stress the townspeople experienced, showing that the pillars are intertwined and connected to each other.

Here in the States, generous, oversized portions of food are valued greatly. But in Blue Zones, Buettner found that people stopped eating when they were mostly full, not when they finished everything on their plate or were too stuffed to eat another bite. He also observed that the biggest meal of the day occurred in late afternoon or early evening, not right close to bedtime. Scientific research has shown that eating late at night is linked to unhealthy weight gain, which isnt exactly great for lifespan.

Speaking of Blue Zones, heres what to know about the expert-loved Mediterranean diet:

While were on the subject of food, people in Blue Zones tend to eat a diet thats primarily plant-based, consuming meat only a few times a month on special occasions. Processed foods and added sugar have never shown to have a health benefit. Cutting them out is 90 percent of a a healthy diet right there, Dr. Day says. [In Chinas longevity village], they picked their own produce and ate it the same day. And since they were essentially cut off from the rest of the world, they didnt have any access to sugar or processed foods. He also adds that they ate fish about twice a week, which of course brings to mind the Mediterranean diet, a long-beloved eating plan by doctors and dietitians.

Across Blue Zones, Buettner observed that alcohol was consumed, but moderately, at one to two glasses a day, with friends or food. This makes sense, as light to moderate drinking (particularly of wine) has been associated with a longer lifespan. According to a 2017 333,000-person, eight-year analysis, those who enjoyed an occasional drinkseven or less per week, to be exactwere 20 percent less likely to die of any cause and 25 percent to 30 percent less likely to die of cardiovascular disease than those who were completely sober. The key, of course, is to be mindful.

A sense of family and community is important in all Blue Zones communities, which Dr. Honaker says has been directly linked to health. Many studies have shown lower rates of hypertension, obesity, diabetes, and possibly even cancer for people with lots of friends and loving relationships in their lives, he says.

Dr. Day observed first-hand how belonging affected the health of the people in Chinas longevity village. Our research showed that as long as people stayed in the village and adopted the village lifestyle, they were healthy and aging was slowed, he says. However, if they left for employment in one of the big cities in China then their health suffered.

Similarly, in Blue Zones, families tend to be close, both geographically and emotionally. Younger generations value and help care for older ones. Dr. Day says that healthy aging requires a close network of friends and family who share their health goals and values, not something people can do on their own. This may too be related to a sense of belonging. This may be in part to the healthy lifestyles happy people adopt along with other factors we cannot measure, Dr. Honaker says.

People in Blue Zones areas not only have supportive families and communities, they actively participate in them. For some, faith may be the cornerstone of their social life, which Dr. Honaker says can provide both comfort and camaraderie through a shared beliefs system. As with purpose, study after study suggests that having a faith may increase longevity, Dr. Days says of this connection, adding that faith often involves frequent social gatherings. Another study published in 2016 emphasizes the importance of even casual social relationships when it comes to longevity.

Heres more intel on exactly how relationships impact your health. Plus, why chili peppers are linked to longevity.

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The longest-living people in the world have these 9 things in common - Well+Good

On this weeks episode of The Dropcast, hosts Jian DeLeon and Noah Thomas are joined by Treis Hill and Rob Cristofaro, partners-in-crime at Alife, who are on to celebrate the 20th anniversary of the New York City-based lifestyle, street, and skatewear brand.

The quick hits start off with Kiths co-branded apparel capsule in collaboration with Nobu and their dinner event which took place at the worlds most recognized Japanese restaurant (2:48). While Noah was filling up on sushi as a Nobu regular (shout out to Uncle Woody), Jian was knee-deep in work at the office. Treis notes the merging of food with fashion as the cast expresses their mutual love for authentic restaurant merch (4:30). Somehow, discussion of the Snow Peak x New Balance sneakers brings us back to food again more specifically, food utensils, including the worlds most luxurious spork (8:06).

Talk of Burberrys Nova Check fleece jacket drop leads to Rob and Treis sharing the lack of high fashion pieces in their closets and Alifes history of collabs (11:10). Rather, the duo emphasizes the importance of finding relevance in co-branding as seen through their work with Foot Lockers Project Greenhouse (16:13). The initiative focuses on sustainable product design and empowering youth culture through collaboration with mentors.

Alifes multifaceted identity, which includes being a museum, extends their storytelling beyond pure products as seen with their recent partnerships with Brooklyn Museum and The Bronx Museum of the Arts. When the latter held an exhibit for street art photographer Henry Chalfant who produced a body of work referred to as the Bible of graffiti (22:53), Alife injected their contemporary DNA into the collaboration by creating a pop-up retail space selling a capsule featuring Chalfants work.

In light of their 20th anniversary, Alife is collaborating with Lee Jeans who are also celebrating 130 years in the making (26:00). This leads up to the Question of the Week (QOTW): Whats your favorite Alife collab? (29:08) with the hosts giving their takes.

The cast wraps up the episode by making the rounds in Whatd You Cop? Rob got his hands on the iPhone 11 Pro while Treis got a pair of red Chuck 70s.

Check up on our next QOTW out Monday on Highsnobietys Instagram, and make sure to leave us a voicemail on The Dropcast hotline at 833-HIGHSNOB (833-444-4766) for a chance to be featured in a future episode.

Relevant links:

KITH Cooks Up a Co-Branded Collection With Nobu

Snow Peaks New Balance Sneaker Collab Is for Mountain Adventurers & City Dwellers

Nike Gives the Blazer Mid 77 Vintage a Snakeskin Swoosh

Get FW19 Ready, Head-to-Toe, With These Fleece & Shearling Highlights

Patta Celebrates 15th Anniversary With NYC Pop-Up & Insane Collabs

Rowing Blazers & Barbour Team up for Japanese Exclusive Capsule

Foot Locker, Inc. & Greenhouse Collab With VFILES, Alife, Diet Starts Monday, & More for Innovation Incubator

Read Full Article

See the rest here:
The Alife Guys Talk About Longevity and New Collabs - Highsnobiety

Here's a snapshot of a few stories we particularly enjoyed. Click on the links to read them in full. You can also see all the week's yarns here.

Nature giveth, and humans taketh away

Nature has been supporting life on Earth for millennia. But human exploitation of her generous resources is wearing thin, and an interactive global map created by a large team of scientists from the US, Canada and Europe models where and how.

Read the full story here.

Rumbles, screams and dinks and donks: the sounds of Mars

Scientists listening to recordings made by NASA's Mars InSight lander have discovered a rich haul although many of the sounds captured turn out to made by the machine itself.

Read the full story here.

Canine pals could be key to longevity

As most dog owners will attest, four-legged canine companions generate boundless love and joy through their playful antics and tail-wagging devotion.

Accordingly, much research finds they can improve mental health - and now, evidence for their tangible physical health benefits is growing.

Read the full story here.

Would you like some chemicals with that?

If anyone needs another good reason for choosing home-cooked food over restaurants or take-out, here it is: a study has found it lowers exposure to fluorinated chemicals commonly lurking in food packaging.

Read the full story here.

Traffic-light system can predict repeat earthquakes

Earthquake researchers believe they have found a traffic-light style warning system that can determine if a big earthquake is a prelude to an even larger event, or is itself the main shock.

Read the full story here.

More fuel for early Anthropocene

New research from the nation of Belize, Central America, has revealed that ancient Maya culture responded to population and environmental pressures by creating massive agricultural features in wetlands, potentially increasing atmospheric CO2 and methane through burning forests and farming.

Read the full story here.

And here's our image of the week

European Southern Observatory

The rather uninspired name of this jellyfish galaxy, ESO 137-001, belies this breathtaking image, created by composite data from several telescopes.

To view all this week's featured images, click here.

Read more here:
What you might have missed - Cosmos

This has been a big week for Social Security beneficiaries. Yesterday, nearly 64 million monthly benefit recipients found out exactly how much of a "raise" they'll be getting in 2020. And while it's nowhere near as robust as the cost-of-living adjustment (COLA) that was passed along this year, it's far and away better than the 0% COLA passed along in 2010, 2011, and 2016, or the minuscule 0.3% COLA in 2017.

However, Social Security's COLA reveal also means it's time to look forward to a host of changes in the program for the following year. For example, the rich will have to hand over a bit more in payroll tax in 2020 than they did in 2019, and the long-term disabled (along with the blind) will be able to earn more each month before their disability checks would be stopped.

Image source: Getty Images.

But the most notable change of all might just be the increase in the full retirement age by another two months to 66 years and eight months for those born in 1958. The full retirement age (also known as "normal retirement age" by the Social Security Administration) is the age at which you become eligible to receive 100% of your monthly benefit, as determined by your birth year.

When Social Security was signed into law back in August 1935, the full retirement age was set at 65. It would remain at this level through the year 1999. Mind you, the system didn't work back then as it does today. This is to say that beneficiaries didn't have the option of choosing to claim earlier than age 65. The early claiming option that allowed workers to begin taking a reduced payout as early as age 62 was signed into law in 1961 by President John F. Kennedy. Thus, up until 1961, workers had no choice but to wait until age 65 to receive their payout.

Since 2000, the full retirement age has increased nine times, as part of the Reagan administration overhaul passed in 1983. Each of these increases to the full retirement age has been in two-month increments. Between 2000 and 2005, the full retirement age for persons between 1938 and 1943 increased by two months annually, ultimately rising from 65 to 66. Then, after a more-than-one-decade lull when the full retirement age stood at 66, it began increasing again in 2017. It'll peak at age 67 in 2022 for those born in 1960 and later.

Next year, when the program's full retirement age climbs to 66 years and eight months, it'll mark just the 10th time in 85 years that it's increased.

Image source: Getty Images.

This may not seem like a big deal, but the full retirement age is arguably one of the biggest problems with the Social Security program.

Back in 1940, when the very first benefit checks were doled out to eligible workers, the average life expectancy for a baby born in the U.S. was 60.8 years for men and 65.2 years for women. As of 2017, it had risen to 78.6 years for the average baby. Put another way, in the time it's taken for Social Security's full retirement age to rise by less than two years, the average life expectancy has increased by approximately 15 years. There are some pretty major implications for this disparity.

When the program was signed into law, it was designed with the idea that it would provide a financial foundation for those workers who could no longer provide for themselves. But the expectation is that these payouts would continue for years, not decades. Today, the Social Security Administration finds that the average 65-year-old will live another 20 years. That's potentially two or more decades of payouts, and it's clearly becoming a burden on the program.

Rising income inequality has also led to the exploitation of this disparity between the full retirement age and longevity. Since the well-to-do have little or no financial constraints when it comes to receiving preventative care, medical care, or prescription medicine, they're living substantially longer than the low-income workers that Social Security was truly designed to protect. Not only does this mean that wealthier individuals are, on average, receiving a Social Security payout for decades at a time, but this payout is considerably higher than the average monthly benefit paid to retired workers.

Image source: Getty Images.

So, why hasn't the full retirement age been increased to reflect rising longevity and ease some of the burden on the Social Security program? The issue is that increasing the full retirement age is akin to cutting benefits, and that's a big no-no for a lot of politicians on Capitol Hill.

Since your full retirement age represents the point at which you become eligible to receive 100% of your monthly payout, gradually raising it over a period of years or decades means reducing the lifetime earning potential of future generations of workers.

For example, one of the core solutions to Social Security's imminent cash shortfall offered by Republicans is the idea of gradually increasing the full retirement age from 67 to as high as 70. While sparing current and near-term retirees, such a move would likely require millennials and generation Z to either wait longer to collect their full payout or to accept an even steeper reduction by taking their benefit early. Thus, future generations of retired workers would have fewer years to collect if they wait, or would receive even less each month if claiming early. No matter their choice, the amount paid out by the program would be less than under the current model. It's a cut to long-term benefits.

Democrats in Washington, D.C. simply won't support any legislation that reduces benefits, either on an up-front or long-term basis. This is why legislation that increases the full retirement age, or even offers to index it to longevity, is unlikely to be addressed anytime soon.

Follow this link:
This Social Security Change in 2020 Will Happen for Only the 10th Time in 85 Years - The Motley Fool

Reports Predict Growth in Global Automotive ACC ECUMarket research report highlights 2020 projection of business, market supercharge growth and challenges, new strategic technology and progressive approach innovations, future roadmap and forecast to 2029.

Acumulative analysis on Automotive ACC ECU Markethas included a report by Market.us, offers an exhaustive study based on current trends influencing this vertical throughout assorted geographies. Key data regarding different market size, world new comparative market share, statistics, growing application, and revenue are compiled in the research to develop an ensemble prediction. Additionally, this research provides an in-depth competitive analysis concentrating on business prognosis highlighting expansion plans accepted by marketplace volatility.

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Dont miss out on business opportunities inAutomotive ACC ECU Market | Get PDF Sample For Technological Breakthroughs:https://market.us/report/automotive-acc-ecu-market-request-sample/

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Competitive Analysis:

The global automotive acc ecu market 2020, research study putt a lot of stress on regulative problems, macro-economic influencing factors, key market trends and growth drivers that are changing the industry dynamics of the market. The study incorporates industry esteem chain, powerful business strategies, cost, structure, creation limit, conveyance, market range and limits usage rate. The Research study evaluating the region-wise market status, highlighting opportunities, risk analysis, and leveraged with strategic decision-making support bytop manufacturers-Bosch, Denso, Fujitsu, Continental, Autoliv, Delphi, ZF, Valeo, Hella.

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1. New 2020 report covers the forecast and analysis for the Automotive ACC ECU Market on a global and regional level.

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The main goal of this research study is to provide a clear picture and a better understanding of the market for the research report to the manufacturers, suppliers, and the distributors operational in it. The readers can gain a deep insight into this market from this piece of information that can enable them to formulate and develop critical strategies for the further expansion of their businesses.

Fill the Pre-Order Inquiry form for the report (Use Corporate Details Only):https://market.us/report/automotive-acc-ecu-market/#inquiry

Segment Snapshot:

By Type Coverage (Volume and Value from 2020 to 2029)

OEMAftermarket

By End-Use Application Coverage (Volume and Value from 2020 to 2029)

Passenger VehicleCommercial Vehicle

Promising Regional Description:

The most substantial areas covered from the accounts of global automotive acc ecu market areEurope, Asia-Pacific, North America, Latin America and the Middle East and Africa.

Factors that can be investigated through Global Automotive ACC ECU Market research include:

Market information:

* Prices of different commodities in the market

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Market Trends:Market trends are the upward or downward movement of a market, during a period of time.

SWOT Analysis:SWOT is a written analysis of the Strengths, Weaknesses, Opportunities and Threats to a business entity

Some of the Major Highlights of TOC Covers:

Chapter 1.Industry Overview

Chapter 2.Executive Summary

Chapter 3.Methodology and Scope

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Chapter 6.Company Profiles

Chapter 7.Appendix

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An embellished scenario of the parent market

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comprehensive segmentation of the target market

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Competition landscape

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Browse More Insight Of This Premium Research Report Enabled with Respective Tables and Figures athttps://market.us/report/automotive-acc-ecu-market

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Market.us offers its clients a one-stop solution platform for all market research needs. Our focus on custom research, consulting projects, syndicate reports covers a variety of industries, sectors, and verticals, and we cover niche market titles, and we also cater to client-specific requirements. Analysts at Market.us have access to large databases of statistical information, Customs Import and Export Database, Industry Association Database, etc., besides expert resources and participants. Our expert panel includes specialists in industries and sectors such as energy, automotive, chemicals, healthcare, medical, ICT consumer goods, banking & finance, mining & minerals, food and beverages, agriculture and other related fields, aerospace, machinery & equipment, etc., apart from professional survey teams and competent teams of data analysts and researchers.

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Sustainability and Longevity: New Trends in the Global Automotive ACC ECU Market 2020-2029 - Motor Expo

EAST POINT, Ga. When Ricky Bevins started working part-time at Dandie Scottie Kennel nearly ten years ago, he never dreamed that one-day, taking care of pets would become his full-time career. However, in the fall of 2016, he became the third owner of one of the oldest kennels in the Tri-Cities.

Tucked alongside the rows of non-descript buildings that line the industrial corridor of Central Ave, the modest pea soup green one-story barely registers a glance in the shadow of the massive SA Recycling scrap yard. Chances are that many a Tri-Cities resident has driven past it as they trek from East Point to Hapeville or vice-versa.

Dandie Scottie originally began as a dog breeder for Scottish Terriers but Bevins tells My East Point news that by the time he took over the reins, that practice had fallen by the wayside. Although, he is proud to admit that the last dog breed at the kennel is still kicking and still gets groomed at Dandie Scottie.

While he may not have been the original owner of the kennel for its sixty-plus year history, Bevins attributes the longevity of the business to 3 things: customer service, knowing your product and refusal to quit.

Anyone that does business in East Point, lives in East Point, comes through East Point. Its their responsibility to try to lift East Point up, said Bevins.

Want more Tri-Cities news? Like us on Facebook.

RELATED:Faith and family legacy: East Point's little print shop that could

Everything is (still) coming up roses for local business

Tri-Cities non-profit helps neighborhood cats live their best lives -- all nine of them

See the article here:
'Groomed for success' | Local kennel discusses the secret to their longevity - 11Alive.com WXIA

The new cars that owners keep the longest before reselling are mostly sports cars and SUVs, according to a study by car search engine iSeeCars.com.

Most owners keep their new cars for an average of 8.4 years, but the ten vehicles on the list averaged 9.7 to 11.4 years.

Almost all the sports cars on the list with the exception of the Porsche 911 in the coupe body style are the convertible versions. iSeeCars CEO Phong Ly claims this is because convertibles are the least-driven type of car and typically amass 60% fewer miles than the average car.

Read more: The 10 cars owners ditch after less than a year more than any other, according to data

"Sports cars typically aren't daily drivers and don't accrue high mileage as a result, so it takes them longer to show signs of wear and tear," Ly said in a prepared statement. "Because sports cars aren't typically used as primary vehicles, owners likely aren't as concerned with having the latest and greatest technology and safety features."

iSeeCars.com analyzed over 5 million cars to identify which models were kept the longest before being sold by their original owners between January 1, 2014 and December 31, 2018. Cars owned for less than five years were excluded from the data set.

Check out the new cars owners keep the longest:

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The 10 new cars owners keep the longest are mostly sports cars, SUVs - INSIDER