header logo image


Page 822«..1020..821822823824..830840..»

Surgeon banned over ‘quack’ procedures and ‘reckless disregard’ for safety – Sydney Morning Herald

November 9th, 2019 2:45 am

Dr Bright, who voluntarily surrendered his registration on August 31, was banned from reapplying for seven years.

He was also ordered to pay the costs of the Health Care Complaints Commission (HCCC), which filed the complaints against him in January.

Dr Bright founded Macquarie Stem Cells in Liverpool, which on its website spruiks its experimental treatments as "lead[ing] the way" and "our way of giving back to the community".

Dr Bright was referred to the HCCC by deputy state coroner Hugh Dillon in 2016 over the "preventable" and "unnecessary" death of an elderly patient after an experimental liposuction stem cell procedure to treat her dementia.

The coroner found the 75-year old died due to a "cluster of errors", including a failure to stop taking blood thinning medication prior to surgery, resulting in uncontrolled blood loss.

The tribunal agreed with Coroner Dillon that the treatment bore the hallmarks of "quack medicine".

It also accepted the evidence of Professor Colin Masters from the University of Melbourne, who said there was no evidence stem cell therapy for dementia patients was safe and it was "completely inappropriate and unethical" on a person who was frail, in poor health and in an advanced stage of dementia.

The tribunal found no proper therapeutic basis for Dr Bright administering the same stem cell treatment on a "very vulnerable" patient suffering bilateral vestibular deficiency, a condition where there is difficulty maintaining balance.

The tribunal accepted the patient - who was allegedly told by Dr Bright the procedure was "100 per cent safe" - has been adversely impacted.

The other complaints upheld related to Dr Bright's prescribing of peptides to three patients, including a woman with terminal motor neurone disease.

The tribunal found Dr Bright did not conduct a proper assessment on a patient before prescribing peptides and failed to take adequate steps to obtain informed consent, including an acknowledgement of the lack of clinical data proving the effectiveness of peptides and potential side effects.

Dr Bright's extensive self-prescribing of peptides was "improper and unethical", the tribunal found.

Dr Bright denied the allegations through his lawyers earlier in the year, but instructed his legal team to cease acting for him in August.

He did not attend the tribunal's hearing and did not respond to the orders it handed down.

Carrie Fellner is an investigative reporter for The Sydney Morning Herald.

See the original post:
Surgeon banned over 'quack' procedures and 'reckless disregard' for safety - Sydney Morning Herald

Read More...

Global Canine Stem Cell Therapy Market 2019, Trend, CAGR Status, Growth, Analysis and Forecast to 2024 – Techi Labs

November 9th, 2019 2:44 am

Former Google CEO Eric Schmidt has a vision for healthcare.

He explained it on a recent episode of the podcast Theory and Practice, which focuses on the intersection of biology and computer science. The podcast is produced by Google AI and the venture arm GV, which was formerly known as Google Ventures.

Schmidt, a billionaire who studied electrical engineering at Princeton University, was Googles CEO for a decade and later served as executive chairman. He left that role at Googles parent company, Alphabet, in 2018.

Schmidt has long held beliefs about the important role of big data and data sharing, he said. Data sharing has faced obstacles in healthcare, where the privacy of personal health data is a big concern.

Schmidt said he believed that better data access and sharing would improve healthcare.

If you look at the medical system in America, it was never designed in a way that you and I would sort of agree as rational. The incentives are misaligned; the databases are poor, Schmidt told the cohosts Anthony Philippakis, a venture partner at GV, and Alex Wiltschko, a senior research scientist with Google AI.

I believe that because of the gains in machine learning and data analysis, we have an opportunity to rethink some of those underlying assumptions, he added.

Because of the disjointed nature of the US healthcare system, Schmidt said that all medical data should be in one place that is easy for the doctor and patient to access.

When I go to the doctor, I want to give them a login and a password for me, and when they log in, I want them to see all of my medical data from everywhere, Schmidt said.

As Schmidt said in the podcast episode that, oftentimes, when a patient has to have multiple tests done by different specialists, the medical information is not shared between their systems. This is just one example of the disconnected communications that Schmidt says could easily be fixed.

Another important point to fix is making large amounts of health data available for research purposes. Schmidt said the privacy issue could be resolved by allowing patients to opt out of data collection. Otherwise, that data is, by custom, made available for research purposes to make the system stronger, he said.

Schmidt said that a key step would be to put all medical data on the cloud, where it can more easily be accessed and analyzed.

Right now, the majority of medical data is not even in the electronic-health-record system, its in other systems that are sitting around in the hospital, Schmidt said. But the work is underway, and all EHRs will be cloud-based quite soon.

For Schmidt, cloud computing is beneficial in healthcare because its often less expensive and can support the massive amounts of data the industry constantly produces.

With cloud computing, you know the system wont fall over, he said.

But Schmidt doesnt just want to store electronic health records on the cloud. He also wants to collect other clinical data from hospital systems and eventually all clinical data in the healthcare industry.

Wed have a much fuller picture of whats going on in a medical care setting, and that would allow us to do better data analytics, better prediction and better healthcare, Schmidt said.

Schmidt said he believed healthcare systems would be quick to move to the cloud if it could prove to be beneficial for the patient and doctor by saving time and peoples lives.

With access to more patient data, Schmidt believes computers can help the healthcare system by providing more accurate medical diagnoses for a larger group of people.

Big data can provide better predictive analytics, he said. He said deep data science could be used to help doctors make better decisions.

I want a computer to be able to say, Heres your history; heres what we think is going on, and give advice using deep data science, doing deep predictive analytics, and AI in general to predict what the doctor should do next, Schmidt said. I think this will lead to a revolution in healthcare in terms of productivity and, most important, my health and your health and everyones.

Link:
Global Canine Stem Cell Therapy Market 2019, Trend, CAGR Status, Growth, Analysis and Forecast to 2024 - Techi Labs

Read More...

Viral Inactivation Market Global Research and Study by Experts 2019 to 2025 – The Market Publicist

November 9th, 2019 2:44 am

The globalViral Inactivation Marketis carefully researched in the report while largely concentrating on top players and their business tactics, geographical expansion, market segments, competitive landscape, manufacturing, and pricing and cost structures. Each section of the research study is specially prepared to explore key aspects of the global Viral Inactivation market. For instance, the market dynamics section digs deep into the drivers, restraints, trends, and opportunities of the global Viral Inactivation market.

With qualitative and quantitative analysis, we help you with thorough and comprehensive research on the global Viral Inactivation market. We have also focused on SWOT, PESTLE, and Porters Five Forces analyses of the global Viral Inactivation market.

Leading companies operating in the Global Viral Inactivation market profiled in the report are:

Danaher

Merck

Parker Hannifin

Sartorius

SGS

Charles River Laboratories International

Clean Cells

Rad Source Technologies

Texcell

Viral Inactivated Plasma Systems

Wuxi Pharmatech (Cayman)

Get a Sample Copy of the Report:

https://www.marketinsightsreports.com/reports/01011041155/global-viral-inactivation-market-size-status-and-forecast-2019-2025/inquiry?Mode=88

Market Segment by Type, covers:Kits and Reagents

Services

Viral Inactivation Systems and Accessories

Market Segment by Applications, covers:Blood and Blood Products

Cellular and Gene Therapy Products

Stem Cell Products

Tissue and Tissue Products

Vaccines and Therapeutics

Regional Analysis For Viral Inactivation Market:

North America (United States, Canada and Mexico)Europe (Germany, France, UK, Russia and Italy)Asia-Pacific (China, Japan, Korea, India and Southeast Asia)South America (Brazil, Argentina, Colombia etc.)Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

Inquire For Discount:

https://www.marketinsightsreports.com/reports/01011041155/global-viral-inactivation-market-size-status-and-forecast-2019-2025/discount?Mode=88

-Comprehensive assessment of all opportunities and risk in the Viral Inactivation market.

-Viral Inactivation market recent innovations and major events.

-Detailed study of business strategies for growth of the Viral Inactivation market-leading players.

-Conclusive study about the growth plot of Viral Inactivation market for forthcoming years.

-In-depth understanding of Viral Inactivation market-particular drivers, constraints and major micro markets.

-Favourable impression inside vital technological and market latest trends striking the Viral Inactivation market.

-Key Strategic Developments: The study also includes the key strategic developments of the market, comprising R&D, new product launch, M&A, agreements, collaborations, partnerships, joint ventures, and regional growth of the leading competitors operating in the market on a global and regional scale.

-Key Market Features: The report evaluated key market features, including revenue, price, capacity, capacity utilization rate, gross, production, production rate, consumption, import/export, supply/demand, cost, market share, CAGR, and gross margin. In addition, the study offers a comprehensive study of the key market dynamics and their latest trends, along with pertinent market segments and sub-segments.

-Analytical Tools: The Global Viral Inactivation Market report includes the accurately studied and assessed data of the key industry players and their scope in the market by means of a number of analytical tools. The analytical tools such as Porters five forces analysis, SWOT analysis, feasibility study, and investment return analysis have been used to analyse the growth of the key players operating in the market.

Browse Full Report at:

https://www.marketinsightsreports.com/reports/01011041155/global-viral-inactivation-market-size-status-and-forecast-2019-2025?Mode=88

ABOUT US:

MarketInsightsReports provides syndicated market research on industry verticals including Healthcare, Information and Communication Technology (ICT), Technology and Media, Chemicals, Materials, Energy, Heavy Industry, etc. MarketInsightsReports provides global and regional market intelligence coverage, a 360-degree market view which includes statistical forecasts, competitive landscape, detailed segmentation, key trends, and strategic recommendations

Irfan Tamboli (Head of Sales) Market Insights Reports

Phone: + 1704 266 3234 | +91-750-707-8687

sales@marketinsightsreports.com | irfan@marketinsightsreports.com

Excerpt from:
Viral Inactivation Market Global Research and Study by Experts 2019 to 2025 - The Market Publicist

Read More...

Market Segmentation: Global Stem Cell Banking Market Analysis; What are the Limitation of the Market? How can these Limitation be Overcome? -…

November 9th, 2019 2:44 am

The global stem cell banking industry is estimated to grow from USD 5.68 billion 2017 to USD 9.87 billion by the end of 2024 showing a growth rate of 8.21%.

Click here for more information @https://www.reportocean.com/industry-verticals/details?report_id=21506

The new report has been added to the reportocean.com depository that provide management with accurate, relevant, valid, and current information related to Stem Cell Banking Market. The Stem Cell Banking industry report 2019, help Stem Cell Banking Companies or new entrants in the Stem Cell Banking industry to stay competitive and avoid the risk of poor decisions based on unsound information.

The listed Stem Cell Banking study helps the marketing managers to develop an understanding about the suppliers, consumers, channel partners, competitors, Stem Cell Banking growth outlook, industry trends, key strategies (Stem Cell Banking industry mergers & acquisitions, collaboration, Partnership, etc.), and new product/service developments. Also, the study does focus on market share of Stem Cell Banking major players and market size value.

Moreover, the Stem Cell Banking market research report 2019 helps to identify Stem Cell Banking market year-on-year growth in global, regional, and country level, along with various possible Stem Cell Banking industry segments/verticals. The Stem Cell Banking report provides you market size data for historical, present, and forecast years along with the CAGR for regional, country and Stem Cell Banking industry segments.

To know the Key player profile in the report, send a sample request athttps://www.reportocean.com/industry-verticals/sample-request?report_id=21506

The major region/countries coverage in our reports are:

North America (United States, Canada)

Europe (Germany, UK, France, Italy, Spain, Belgium, Russia, Netherlands, Rest of Europe)

Asia-Pacific (China, Japan, India, Korea, Singapore, Malaysia, Indonesia, Thailand, Philippines, Rest of the Asia-Pacific)

Latin America (Mexico, Brazil, Argentina, Rest of LATAM)

Middle East and Africa (UAE, Saudi Arabia, South Africa, Rest of MEA)

The country-level information can be provided for other countries also, as the scope is not limited to above mention countries only, it may be varying upon the scope of the market.

The Global Stem Cell Banking report helps you with the:

Recognizing potential opportunities and problems related to Stem Cell Banking market

Investing tactics

Planning and execution of the marketing campaign

Identify promising new partners and suppliers

Identify the Target market

Produce, examine, and improve market actions

Clear understanding of the responsiveness of different segments in the Stem Cell Banking industry

The report consists of detailed insight for the Global Stem Cell Banking market that includes realistic overview of the industry, consist of Stem Cell Banking manufacturers data, i.e. financial overview, recent developments, gross profit, business distribution, and product benchmarking, etc., Moreover, report also talk about SWOT analysis, mega trends, company profile, drivers and restrain factors, gap analysis, investment opportunity, forecast market size, Porters Five Models, services and products, socioeconomic factors, government regulation in Global Stem Cell Banking industry.

The report, in short, is very rigorously prepared and is as authentic and reliable as it can be.

For getting a better understanding of the segments, click herehttps://www.reportocean.com/industry-verticals/details?report_id=21506

Important Coverage of the Report:

The Stem Cell Banking market has been segmented on the bases of different types/applications/channels/end users to provide deep down-market insight for the historic, current, and future market trends. In fact, the report produces a very careful analysis to provide a comprehensive view of the market after considering all commissions and omissions.

1) Stem Cell Banking Market Overview

a. Market Definition

b. Industry snapshot

c. Ecosystem analysis

2) Stem Cell Banking Market Competitive Landscape

a. Market Share Analysis

b. Major Growth Strategy in the Global Stem Cell Banking Market

c. Competitive Benchmarking

d. Leading Player in terms of Number of Developments in the Market

3) Stem Cell Banking Major Players Company Profiles

a. Revenue and Gross profit 2016-2018

b. Business Revenue by Region

c. Business Segments Revenue

d. Business Profile

e. Products/Service offering

f. Key Strategy

g. SWOT Analysis

4) Global Stem Cell Banking Market Segmentation (Market Estimates and Forecast 2016-2026*) USD Million

a. Industry Level Segment

Market Estimates and Forecast, by Global, 2016-2026

Market Estimates and Forecast, by Region, 2016-2026

Market Estimates and Forecast, by Country, 2016-2026

b. Channel level Segment

Market Estimates and Forecast, by Global, 2016-2026

Market Estimates and Forecast, by Region, 2016-2026

Market Estimates and Forecast, by Country, 2016-2026

c. Product Type Segment

Market Estimates and Forecast, by Global, 2016-2026

Market Estimates and Forecast, by Region, 2016-2026

Market Estimates and Forecast, by Country, 2016-2026

d. End-User Segment

Market Estimates and Forecast, by Global, 2016-2026

Market Estimates and Forecast, by Region, 2016-2026

Market Estimates and Forecast, by Country, 2016-2026

e. Others Segment

Market Estimates and Forecast, by Global, 2016-2026

Market Estimates and Forecast, by Region, 2016-2026

Market Estimates and Forecast, by Country, 2016-2026

5) Market Dynamic

a. Drivers

b. Restrain

c. Opportunity

d. Trends

6) Market Factor Analysis

a. Supply/value chain analysis

b. Porters five forces

c. Regulatory Scenario*

7) Conclusion

For getting a better understanding of the segments, send us a Sample Request athttps://www.reportocean.com/industry-verticals/sample-request?report_id=21506

Parameters for the Study:

The comprehensive study has been prepared carefully by considering all possible parameters. Some of these were

Factors that impact the market growth

Consumers options and preferences

Technological environment and facilitators

Perceived challenges and constraints

Law and regulations analysis

Opportunities

Consumer spending dynamics and trends

Other developments

Follow us on:

Facebook: https://www.facebook.com/reportocean

Twitter: https://twitter.com/reportocean

LinkedIn: https://in.linkedin.com/company/reportocean

Contact: +1 888 212 3539 (US) +91-9997112116 (Outside US)Contact Person: Sandeep SinghEmail:sales@reportocean.com

Continued here:
Market Segmentation: Global Stem Cell Banking Market Analysis; What are the Limitation of the Market? How can these Limitation be Overcome? -...

Read More...

Pub talk will explore links between icefish and human aging – AroundtheO

November 9th, 2019 2:41 am

Fish that adapted to survive in the frigid waters of Antarctica offer a gateway to better understand the genetics of human aging, but the fish are being threatened by climate change, says University of Oregon biologist John Postlethwait.

Thats the message he will deliver Nov. 13 in a Quack Chats pub talk at Eugenes Downtown Athletic Club, 999 Willamette St. The talk will begin at 6 p.m. in the third-floors Ax Billy Grill.

These are remarkably beautiful and complex animals, said Postlethwait, a professor emeritus and member of the UOs Institute of Neuroscience. Climate change is threatening them. We need to study them more before they become extinct or try to change the conditions so that we limit the effects of climate change and maybe reduce the chances of extinction.

Postlethwait traveled five times to Antarctica between 2008 and 2018 with funding from the National Institutes of Health and National Science Foundation. He has studied dragonfish and icefish, primarily the low bone mineralization that evolved in bottom-dwelling icefish to allow them to increase their buoyancy and rise in the water column to feed.

That adaptation of turning off certain genes to become less dense in the absence of swim bladders think lungs in humans began about 30 million years ago as Antarctic waters cooled. Todays seawater temperature there hovers just below the freezing point of fresh water.

The bones in these fish look like old peoples bones, said Postlethwait, who ran a marathon in Antarctica during one of his research trips. As people age, they turn off or turn down the genes that are important for maintaining bone health.

In his talk, Dragons and Icefish: Surviving Frigid Antarctic Seas, hell detail the biology and molecular genetics of these Antarctic fish and how they hold genetic clues that may be useful for understanding anemia, oversized hearts and low bone-mineral density in humans.

The potential human health payoff was boosted earlier this year when an international team that included Postlethwait and six other UO researchers published the complete genome sequence for Antarctic blackfin icefish.

To learn more about upcoming Quack Chats, see the Quack Chats section on Around the O. A general description of Quack Chats and a calendar of additional Quack Chats and associated public events also can be found on the UOs Quack Chats website.

By Jim Barlow, University Communications

Read more from the original source:
Pub talk will explore links between icefish and human aging - AroundtheO

Read More...

UBC cannabis researchers find that "frosty" flowers mean potent pot – Straight.com

November 9th, 2019 2:41 am

A team of UBC researchers used advanced techniques in microscopy and chemical profiling to determine that cannabis flowers with the biggest hairs produce the most CBD, THC, and fragrance-emitting terpenes.

The research was the first to detail the structures and chemical-creating abilities of the three kinds of frostlike pot hairsstalked, sessile, and bulbouscalled glandular trichomes.

Finola, a fast-flowering hemp variety of Cannabis sativa, was used by the team, which included researchers from UBC's Wine Research Centre and the Michael Smith Laboratories.

Teagen Quilichini, the study's co-lead author and a postdoctoral fellow with the botany department, said in an October 28 UBC news release that the study is an important beginning for subsequent research.

Despite its high economic value, our understanding of the biology of the cannabis plant is still in its infancy due to restricted legal access, Quilichinisaid. Trichomes are the biochemical factories of the cannabis plant and this study is the foundation for understanding how they make and store their valuable products.

The paper"Cannabis glandular trichomes alter morphology and metabolite content during flower maturation"appeared in the August 30 edition of the Plant Journal.

Anne Lacey Samuels, a botany professor and principal investigator for the study, said in the release that there could be many downstream benefits of the research.

We found a treasure trove of genes that support the production of cannabinoids and terpenes. With further investigation, this could be used to produce desirable traits like more productive marijuana strains or strains with specific cannabinoid and terpene profiles using molecular genetics and conventional breeding techniques.

The UBC team determined under ultraviolet light that the stalked trichomes glowed blue and had large, distinctive secretory discs of cells that looked like microscopic mushrooms or hamburgers.

We saw that stalked glandular trichomes have expanded 'cellular factories' to make more cannabinoids and fragrant terpenes, co-lead author Sam Livingston said in the release. We also found that they grow from sessile-like precursors and undergo a dramatic shift during development that can be visualized using new microscopy tools."

Livingston, a botany department PhD candidate, noted thatUV lightmight be used todetermine flowers' trichome maturity so growers would know the best times to harvest.

Read more here:
UBC cannabis researchers find that "frosty" flowers mean potent pot - Straight.com

Read More...

Myriad Genetics to Present at the 2019 Stephens Nashville Investment Conference – Yahoo Finance

November 9th, 2019 2:41 am

SALT LAKE CITY, Nov. 07, 2019 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (MYGN), a leader in molecular diagnostics and precision medicine, announced today that Bryan Riggsbee, CFO, is scheduled to present at the Stephens Nashville Investment Conference at 12:15 p.m. EST on November 13, 2019, in Nashville.

The presentation will be available to interested parties through a live audio webcast accessible through a link in the investor information section of Myriads website at http://www.myriad.com.

About Myriad GeneticsMyriad Genetics, Inc., is a leading precision medicine company dedicated to being a trusted advisor transforming patient lives worldwide with pioneering molecular diagnostics. Myriad discovers and commercializes molecular diagnostic tests that: determine the risk of developing disease, accurately diagnose disease, assess the risk of disease progression, and guide treatment decisions across six major medical specialties where molecular diagnostics can significantly improve patient care and lower healthcare costs. Myriad is focused on five critical success factors: building upon a solid hereditary cancer foundation, growing new product volume, expanding reimbursement coverage for new products, increasing RNA kit revenue internationally and improving profitability with Elevate 2020. For more information on how Myriad is making a difference, please visit the Company's website: http://www.myriad.com.

Myriad, the Myriad logo, BART, BRACAnalysis, Colaris, Colaris AP, myPath, myRisk, Myriad myRisk, myRisk Hereditary Cancer, myChoice, myPlan, BRACAnalysis CDx, Tumor BRACAnalysis CDx, myChoice HRD, EndoPredict, Vectra, GeneSight, riskScore Prolaris, ForeSight and Prequel are trademarks or registered trademarks of Myriad Genetics, Inc. or its wholly owned subsidiaries in the United States and foreign countries. MYGN-F, MYGN-G.

Excerpt from:
Myriad Genetics to Present at the 2019 Stephens Nashville Investment Conference - Yahoo Finance

Read More...

Q&A: Everything You Need to Know About the Future of CRISPR-Cas9 – Philadelphia magazine

November 9th, 2019 2:41 am

Q&A

Penn's Kiran Musunuru talks to us about the technology that has been both praised and criticized for its ability to alter human DNA and potentially cure disease.

Kiran Musunuru is an associate professor of medicine in genetics in the Perelman School of Medicine at the University of Pennsylvania. / Courtesy

CRISPR, the technology being used to edit genes in humans, remains polarizing. On one end, detractors argue that using the technology for certain purposes, like performing gene editing on embryos, is not only dangerous but unethical. On the other end, proponents say CRISPR has the potential to revolutionize human health, and early data shows they might be right. Despite a medical community that is still split on the issue, researchers in the U.S. are kicking tests of the technology into high gear. Several clinical trials have launched in the U.S. testing CRISPRs ability to treat various diseases.

NextHealth PHL spoke with Kiran Musunuru, an associate professor of medicine in genetics at the Perelman School of Medicine at the University of Pennsylvania about the true potential of CRISPR technology and how we can expect it to evolve in the future.

NextHealth PHL: What exactly is CRISPR?Musunru: CRISPR is sort of a catch-all term that covers a variety of technologies. If youre saying CRISPR, youre referring to a broad set of tools that may do it in different ways but are all intended to do a form of gene editing or genome editing.

How do basic CRISPR technologies work?The simplest form of CRISPR, what I call version 1.0, is the original standard CRISPR that most laboratories and companies interested in developing new therapies use. It is a two-component system. There is a protein and an RNA molecule thats about 100 bases in length. The protein and the RNA molecule come together to create what well call a molecular machine and the purpose of this molecular machine is to scan across any DNA molecule it encounters. So if you put the CRISPR-Cas9 into the nucleus of a human cell, this molecular machine will scan the entire genome.

The machine has two key functions built into it; the first is a GPS function. When you change the first 20 bases in a DNA length (the first 20 bases is basically the address) to whatever address you want, the GPS function makes the machine go through the entire genome and find the sequence that matches the address. The second function of this machine is to protect the genome, like a search-and-destroy function. You put in the address, it goes to that matching place in the genome and then it makes a cut in the DNA.

Cutting the DNA is actually a bad thing but the cells have ways to try to fix that break, and the actual editing is a result of the cell trying to fix that break in the DNA, not from CRISPR itself, interestingly enough.

How does CRISPR turn a break in someones DNA into a good thing?There are a few ways this can happen. The safest thing you can do is to break a gene or turn off a gene. The metaphor I like to use is to think of the whole genome as a book, and each chromosome in the genome is a chapter in the book, and each gene is a paragraph in the chapter. Together, it all has a meaning. But lets say you had to turn off a gene, the equivalent of making that break in the DNA would be like tearing the page through that paragraph. So, the simplest thing the cell can do and will try to do is to simply tape that tear back up. But as you can imagine, sometimes you tape it back up and its fine, the paragraph is still legible and the meaning is still there, and it eventually heals and functions like it did before. But in this case, thats actually not what you want. The outcome that you want with CRISPR is that you actually want to turn off the gene, not to rip it and make it the way it was before.

What has to happen is when you make the tear, the tear is so rough, you get those jagged edges and you try to tape it up but it doesnt quite fit, the letters dont quite match up. You tape it up as best as you can but its illegible, some letters are lost, and the meaning of the paragraph is lost. Thats exactly what happens with gene editing, the cell tries to repair that break in the DNA, doesnt get it quite right, and loses some bases and that messes up the gene and turns it off.

However, in this scenario, you cant really control what happens. All you can hope for is that that tear you make is going to mess up the gene and thats okay if all youre trying to do is turn it off. Most of the trials underway now are about turning off the gene, and theyre all taking advantage of the fact that its relatively easy to mess up genes and turn off genes. Just like tearing a page its crude, but its effective.

Theres CRISPR 1.0, this first generation of the technology thats not very precise and is a bit arduous. What are the newest forms of CRISPR and how are they better than earlier versions of the technology? There is a newer form of the technology called base editing that keeps the GPS function intact but removes the cutting function. In place of the cutting function, it attaches another machine onto CRISPR and makes chemical modifications in certain areas. This version of CRISPR is more like a search and replace. CRISPR provides the search but then another machine attached to it is doing the replacing. With base editing you can make more precise changes, but only rarely will it make exactly the type of change you want.

The latest form of CRISPR is called prime editing, and we still dont have a good sense of how well it works because its so new. Whats tantalizing is that it looks like it can turn CRISPR into a precise word processor or an eraser that allows you to erase a letter and put in a new letter. CRISPR is very much a wave of technology, and as it gets better, its going to allow us to do more and more powerful things.

There are some extreme ideas about what CRISPR can do. Some believe scientists can use the technology to alter hair or eye color or give patients superhuman athletic or intellectual abilities. Is any of this possible with CRISPR?It depends on what traits youre talking about changing. Since eye color and hair color are controlled by single genes, you could possibly make a single gene change with CRISPR. The problem is, how do you get CRISPR to go where it needs to go to change your hair or eye color? How do you get it into all your hair follicles or through all the cells in your eye? It might be a simpler change to make, but it might not be easy to do in a live adult. Scientists have now edited human embryos, resulting in live-born people. Theres been a lot of ethical debate about whether thats a good thing. If you want to change something like hair color in a single cell embryo made through in-vitro fertilization, thats a bit different and might not be as difficult.

There are some very complicated things, like intelligence or athletic ability, that are not going to be easy to change. Youd probably have to change hundreds of genes, and thats not going to happen anytime soon. With CRISPR as it is now, maybe you can change one gene; maybe if you really work at it you can change two genes, but hundreds of genes? Youre not going to be able to do that with CRISPR anytime soon.

What has CRISPR been used to treat so far and what could it be used for in the future?There are multiple trials underway to treat rare liver disorders. More recently CRISPR has been used in clinical trials at Penn where at least three patients have been dosed using CAR T immunotherapy. In this case, theyre trying to make patients cells more effective at fighting cancer. But again, that editing is being done outside the body.

There are some things that seem like they would be difficult to treat, but if its the right type of disease and you can get CRISPR to where you need it to go, it might work. One example is in sickle cell disease. The cells that you need to fix in sickle cell disease are in the bone marrow. Fortunately, bone marrow is relatively straight forward to work with. You take the cells out and edit them with some form of CRISPR outside of the body and then put them back in.

Something like cystic fibrosis would be much harder because it affects the entire surface of potentially multiple organs inside the body. Its much harder to deliver CRISPR to all of those places in the body.

There are two other clinical trials that have started in the U.S. One is from a company called CRISPR Therapeutics to treat sickle cell disease and similar blood disorders. Theres another trial underway to treat a genetic form of blindness and this editing would actually happen inside the body.

Excerpt from:
Q&A: Everything You Need to Know About the Future of CRISPR-Cas9 - Philadelphia magazine

Read More...

Postdoctoral Researcher, Neuroecology – The Conversation AU

November 9th, 2019 2:41 am

About the role

The Neuroecology Research Laboratory lies at the intersection of two major fields of biology (Neurobiology: the study of the nervous system, and Ecology: the study of the interaction between living organisms and their environment). Neuroecology bridges the gap between our knowledge of the neural bases of animal behaviour and the consequences of that behaviour in the context of an animal's habitat and ecology.

We are seeking a Postdoctoral Researcher in Neuroecology to join our team within the Department of Physiology, Anatomy and Microbiology (PAM), School of Life Sciences at La Trobe University, Victoria, Australia.

We use innovative neurobiological techniques such as molecular genetics, bioimaging, electrophysiology, anatomy and behaviour to examine how key elements of the physical environment such as light, sound, odours, and electromagnetic fields are detected and processed by the peripheral and central nervous systems and how this influences their behaviour. The ability to perceive these environmental cues is critical to the survival of each species. Model indicator species are used to assess how ecosystems may be faring in light of climate variability and habitat loss or degradation.

Skills & Experience

Benefits

Please click on this link for a full list of Benefits http://www.latrobe.edu.au/jobs/working/benefits

How to Apply

Closing date: 11pm Sunday 8th December 2019

Position Enquiries: Prof Shaun Collin, TEL: +61 (0)3 9479-3671 Email: s.collin@latrobe.edu.au

Position Description below:

PD Level A Postdoc Neuroecology.pdf

Please submit an online application ONLY and include the following documents:

Please scroll down to apply.

La Trobe University is an Equal Opportunity Employer.

All La Trobe University employees are bound by the Working with Children Act 2005. If you are successful, you will be required to hold a valid Victorian Employee Working with Children Check prior to commencement.

For further enquiries on how to apply for this role, please contact Recruitment Partner Justin Bolton on +61 (0)3 9479 1073

To apply and to view position description please visit http://www.latrobe.edu.au/jobs and search for job number 559000 under current vacancies.

About La Trobe

La Trobe University's success is driven by people who are committed to making a difference. They are creative and highly motivated, pursue new ideas and create knowledge. La Trobe is one of Australia's research leaders, and the largest provider of higher education to regional Victoria. La Trobe University turned 50 in 2017, and over the half century of its existence it has established a reputation as an innovative and accessible university, willing to take risks and take on challenges. Our teaching and research address some of the most significant issues of our time and we're passionate about driving change through operational excellence to benefit the communities we serve.

See original here:
Postdoctoral Researcher, Neuroecology - The Conversation AU

Read More...

Data researcher to molecular scientist: List of winners of the 11th Infosys Prize 2019 – The News Minute

November 9th, 2019 2:41 am

The Prize awarded by the Infosys Science Foundation celebrates the success of the recipients in science and research by recognising their achievements in 6 categories.

Infosys Science Foundation (ISF) on Thursday announced the winners of the Infosys Prize 2019 in six categories - Engineering and Computer Sciences, Humanities, Life Sciences, Mathematical Sciences, Physical Sciences and Social Sciences. The Prize celebrates the success of the recipients in science and research by recognising their achievements in each category. The prize for each category comprises a pure gold medal, a citation and a prize purse of USD 100,000 (or its equivalent in Rupees) this year.

A panel of accomplished jurors comprising renowned scholars and professors shortlisted the winners of Infosys Prize 2019 from 196 nominations. With a history of awarding some of the best talent, who have earned prestigious international honours like Fields Medal and the Nobel Memorial Prize more recently, the ISF believes that this years winners too will leave an indelible impression in their domains. The Infosys Prize not only recognises these outstanding researchers and celebrates their achievements, but in doing so, creates role models who will encourage young minds to explore science as a career option.

S. D. Shibulal, Co-founder, Infosys Limited and President of the Infosys Science Foundation, said, The Infosys Prize continues to recognise exemplary work in scientific research and enquiry. Many Infosys Prize laureates have gone on to contribute significantly in key areas like healthcare, genetics, climate science, astronomy and poverty alleviation, amongst other things. Their work has immediate implications for the human race and the planet. We hope it catalyses social development.

Elaborating on the importance of fundamental research at the event, N. R. Narayana Murthy, Founder Infosys, Trustee Infosys Science Foundation, said, We should start helping our youngsters pursue fundamental research enthusiastically. They should be encouraged and equipped to become contributors to solving huge problems that confront us every day. I want India to be a place where discovery and invention happen every month.

Winners of the Infosys Prize 2019 in the six categories are:

Engineering and Computer Science

The Infosys Prize 2019 for Engineering and Computer Science is awarded to Sunita Sarawagi, Institute Chair Professor, Computer Science and Engineering, Indian Institute of Technology, Bombay for her research in databases, data mining, machine learning and natural language processing, and for important applications of these research techniques. The prize recognises her pioneering work in developing information extraction techniques for unstructured data.

Humanities

The Infosys Prize 2019 for Humanities is awarded to Manu V. Devadevan, Assistant Professor, School of Humanities and Social Sciences, Indian Institute of Technology, Mandi for his original and wide-ranging work on pre-modern south India. He critically reinterprets much of the conventional wisdom about the cultural, religious and social history of the Deccan and south India.

Life Sciences

The Infosys Prize 2019 for Life Sciences is awarded to Manjula Reddy, Chief Scientist, Centre for Cellular and Molecular Biology (CCMB), Hyderabad for her groundbreaking discoveries concerning the structure of cell walls in bacteria. Dr. Reddy and her colleagues have revealed critical steps of cell wall growth that are fundamental for understanding bacterial biology.This work could potentially help in creating a new class of antibiotics to combat antibiotic resistant microbes.

Mathematical Sciences

The Infosys Prize 2019 for Mathematical Sciences is awarded to Siddhartha Mishra, Professor, Department of Mathematics, ETH Zrich, for his outstanding contributions to Applied Mathematics, particularly for designing numerical tools for solving problems in the real world. Prof. Mishra's work has been used in climate models, in astrophysics, aerodynamics, and plasma physics.He has produced codes for complicated realistic problems such as tsunamis generated by rock slides, and waves in the solar atmosphere.

Physical Sciences

The Infosys Prize 2019 for Physical Sciences is awarded to G. Mugesh, Professor, Department of Inorganic and Physical Chemistry, Indian Institute of Science (IISc), Bengaluru for his seminal work on the chemical synthesis of small molecules and nanomaterials for biomedical applications. His work has contributed to the understanding of the role of trace elements, selenium and iodine, in thyroid hormone activation and metabolism, and this research has led to major medical advances.

Social Sciences

The Infosys Prize 2019 for Social Sciences is awarded to Anand Pandian, Professor, Department of Anthropology, Krieger School of Arts & Sciences, Johns Hopkins University for his imaginative work on ethics, selfhood and the creative process. Prof. Pandian's research encompasses several themes such as cinema, public culture, ecology, nature and the theory and methods of anthropology.

See the original post here:
Data researcher to molecular scientist: List of winners of the 11th Infosys Prize 2019 - The News Minute

Read More...

TikToks are teaching Generation Z about science – Massive Science

November 9th, 2019 2:41 am

Have you ever wondered why you wash your rice or soak it overnight before cooking it? Perhaps you wash your rice grains to enhance taste, reduce starch levels, or maybe that's just the way your family has always prepped rice. Thanks to a tip from science communicator Samantha Yammine who came across Dr. Nausheen Sadiq's neat finding while live-tweeting a forum on Diversity and Excellence in Science it turns out there is another reason why, as washing rice actually helps reduce the concentration of heavy metals, like chromium, cadmium, arsenic, and lead.

Heavy metal contamination in crops can be caused by human activities, such as mining, fertilizers, pesticides, and sewage sludge. Compared to most cereal crops though, rice (Oryza sativa L.) actually accumulates more heavy materials, like cadmium or arsenic, where long-term heavy metal intake can cause health risks. For example, long-term arsenic exposure leads to skin disease, high blood pressure, and neurological effects. This is especially important to consider as rice is a staple food across the globe.

Heavy metal contamination in crops can be caused by human activities, such as mining, fertilizers, pesticides, and sewage sludge.

Photo by TUAN ANH TRAN on Unsplash

In a recent study, researchers investigated the effects of different cooking methods (normal, high-pressure and microwave cooking) on the concentration, bio-accessibility and health risks posed by three heavy metals (cadmium, arsenic and lead) in two strains of brown rice. After cooking 100 grams of brown rice grains, researchers evaluated bioaccessibility (i.e. how much of the heavy metal is released for absorption) by mixing rice samples with simulated gastric fluid, and then used spectrometery to measure heavy metal concentration. Lastly, the researchers calculated the health risk posed by the heavy metals by calculating values such as the average daily dose.

Overall, the researchers found that instead of the three different cooking methods, it was the washing process which significantly reduced concentrations of cadmium, arsenic and lead, suggesting that the reduction may be due to rice morphology. For example, lead is found largely in the outer compartments of rice kernels, so lead is more likely to be removed during rice washing.

In contrast, the three cooking methods did impact bioaccessibility i.e. how much of the heavy metal would be released for absorption by the body. Here, washing and soaking isn't enough as rice absorbs water poorly at 25C. This finding was also reflected in calculated values: the average daily doses of cadmium, arsenic and lead were lower in washed and cooked rice, compared to raw rice.

It's worth noting that the European Commission has enforced limits on heavy metal levels - for example, arsenic is currently limited to 200 parts per billion (ppb) for adults and 100 ppb for infants. Both the U.S. and Canada currently have no limits in place for arsenic in food though Canada is currently reviewing a proposal to add maximum levels for arsenic found in white and brown rice, while the U.S. FDA has previously released a (non-binding) risk assessment, suggesting the same 100 ppb levels as Europe.

So the takeaway here is that yes, your family and all those professional chefs have been right all along. Yes, washing rice involves sacrificing some of its nutritional value, but doing so means you can reduce the levels of heavy metals present in grains, and still enjoy dishes like rice cakes. And returning back to Yammine's reporting, Saudiq actually shared that by soaking and washing rice for ~5 mins, you can get rid of 50-100% of these elements. (Thanks Sam!)

Read more from the original source:
TikToks are teaching Generation Z about science - Massive Science

Read More...

A&M partners with VolitionRx for research into cancer screenings for dogs – Texas A&M The Battalion

November 8th, 2019 10:48 am

Texas A&Ms College of Veterinary Medicine & Biomedical Sciences and VolitionRx Limited (Volition) have partnered to develop and test early cancer screenings for animals, namely dogs.

As part of the partnership, A&M veterinary oncologists are testing Volitions Nu.Q, a set of tests for biomarkers in the blood. Volition is an international company that has experience with cancer screenings on humans. The company has recently sought to expand into other fields and markets, looking towards the U.S. market through the veterinary field.

A&M revealed the partnership on Oct. 25, with Dr. Eleanor M. Green, the Carl B. King Dean of Veterinary Medicine, hosting the signing at A&M. According to the colleges website, Green has actively sought out collaborations and innovations in the veterinary field.

According to the Volition website, cancer is associated with abnormal levels of uniquely structured nucleosomes found within the blood. Patients that may have malignant tumours could be identified using the Nu.Q tests. However, doctors would have to confirm the analysis with follow-up procedures.

Associate professor and Dr. Fred A. Palmer and Vola N. Palmer Chair in Comparative Oncology Dr. Heather Wilson-Robles is set to lead the research. Wilson-Robles said that the partnership would look into transferring a process used for humans unto animals.

One of the great things is that Volition sort of pioneered the way in Europe for liquid biopsy techniques for human cancer, Wilson-Robles said. Were in the process of trying to apply those same liquid biopsy techniques to veterinary medicine, which would allow us to run diagnostics that traditionally have been pretty invasive and required heavy sedation or anesthesia and [are] costly and make them a simple blood test.

Wilson-Robles said she hopes to distinguish inflammation from cancer through testing and clear any confusion between the two. She said the hope is cancer is different enough from any other disease that the Nu.Q can have a high percentage rate of correct diagnostics in veterinary cases.

Specific nucleosomes can be associated with [a] specific disease, Wilson-Robles said. Inflammation and cancer generally have higher levels of nucleosomes than others. What wed like to do is develop some basic general assets that try to tell you cancer versus inflammation or other diseases and then provide additional panels which may be able to give more information.

A&M also receives an equity stake in Volition Veterinary Diagnostics Development LLC as part of the arrangement. The stake in the Volition subsidiary company, a company that is owned by a parent company, is 12.5 percent according to the Volition website.

Jeremy Kenny, program manager for veterinary innovation and entrepreneurship with the College of Veterinary Medicine & Biomedical Sciences, said the Volition veterinary subsidiary company would like to enter the market soon. The hope is that the subsidiary company will have a product ready.

Theyre creating a veterinary subsidiary company, Kenny said. The next step is the new veterinary company [will be] creating the product. I believe maybe for early next year, they [will] start selling tests.

See the rest here:
A&M partners with VolitionRx for research into cancer screenings for dogs - Texas A&M The Battalion

Read More...

Associate Professor/Assistant Professor (Animal Physiology) job with CITY UNIVERSITY OF HONG KONG | 185658 – Times Higher Education (THE)

November 8th, 2019 10:48 am

Associate Professor/Assistant Professor (Animal Physiology) in the Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences[Ref. C/527/09]

City University of Hong Kong is a dynamic, fast-growing university that is pursuing excellence in research and professional education.As a publicly-funded institution, the University is committed to nurturing and developing students talents and creating applicable knowledge to support social and economic advancement. The University has nine Colleges/Schools. As part of its pursuit of excellence, the University aims to recruitoutstanding scholarsfrom all over the world in various disciplines, includingbusiness, creative media, data science, energy and environment, engineering, humanities and social sciences, law, science, veterinary medicine and life sciences.

The new Jockey Club College of Veterinary Medicine and Life Sciences at City University of Hong Kong in collaboration with Cornell Universitys College of Veterinary Medicine is assembling an outstanding group of international academics to undertake teaching and research in the Department of Infectious Diseases and Public Health. The Department is rapidly developing as an international research-oriented centre to support veterinary training and research in Hong Kong and the region. It is well positioned to provide a strong link between the preclinical veterinary sciences and applied (clinical) veterinary medicine. In another dimension it focuses on One Health, an area spanning the health of animals, humans and the environment. The Department plays a key role in teaching students for the Bachelor of Veterinary Medicine programme and the MSc in Aquatic Production and Veterinary Health, as well as in other related activities such as enabling postgraduate research opportunities. Departmental faculty members undertake teaching, research and diagnostic service across their areas of specialty.

Applications are invited for the above post:

Duties

Plan and establish world-class teaching and research facilities, teach and manage undergraduate and postgraduate courses, develop new research directions and maintain robust research programmes, and carry out administrative work and any other duties to facilitate the development of the Department and the College as a whole.

The appointee is also expected to contribute to the development and implementation of the professional veterinary curriculum in the area of Animal Physiology modelled on the integrated Function and Dysfunction construct as delivered by Cornell Universitys College of Veterinary Medicine.

Requirements

A PhD in relevant disciplines (Animal Physiology/Animal Science/Animal Nutrition/Digestive Physiology/Veterinary Medicine/Zoology/Biology) or equivalent. Candidates with background in the fields of Digestive Physiology and Nutrition are particularly encouraged to apply.

A veterinary degree registrable in Hong Kong preferred, but not essential. Applicants must have demonstrable evidence of research success (including publishing influential works and obtaining external research funding).

Salary and Conditions of Service

Remuneration package will be driven by market competitiveness and individual performance. Excellent fringe benefits include gratuity, leave, medical and dental schemes, and relocation assistance (where applicable). Initial appointment will be made on a fixed-term contract.

Information and Application

Further information on the posts and the University is available athttp://www.cityu.edu.hk, or from the Department of Infectious Diseases and Public Health, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong (email :chhung@cityu.edu.hk).

To apply, please submit an online application athttp://jobs.cityu.edu.hk, and include a current curriculum vitae, a cover letter, research and teaching statements based on the position.Applications will receive full consideration until the position is filled.Only shortlisted applicants will be contacted; and those shortlisted for the post of Assistant Professor will be requested to arrange for at least 3 reference reports sent directly by the referees to the Department, specifying the position applied for. The University's privacy policy is available on the homepage.

City University of Hong Kong is an equal opportunity employer and we are committed to the principle of diversity. Personal data provided by applicants will be used for recruitment and other employment-related purposes.

Worldwide recognition ranking 52nd, and 4th among top 50 universities under age 50 (QS survey 2020); 1st in Engineering/Technology/Computer Sciences in Hong Kong (ARWU survey 2016); and 2nd Business School in Asia-Pacific region (UT Dallas survey 2017)

Follow this link:
Associate Professor/Assistant Professor (Animal Physiology) job with CITY UNIVERSITY OF HONG KONG | 185658 - Times Higher Education (THE)

Read More...

Cats with stubbed tails more prone to litter box issues – San Antonio Express-News

November 8th, 2019 10:48 am

Dear Cathy,

This letter is in response to the reader with the Manx cat with the litter box problems (Reader says kitty pee pads a lifesaver, Oct. 4).

Her letter reminded me of a woman I worked with in Houston who adopted a shelter kitten with an extremely small stub of a tail, small even for a Manx. The cat had trouble controlling her urinary flow, both timing and location.

A vet examined her and said that cats with vestigial tails frequently have bladder control problems. I took this kitten to a friend who lived out in the country, and she found a good home there.

So, I am wondering if the reader with the Manx cat has taken her cat to the vet for an exam. This bladder control problem might help explain why she goes on the floor rather than in the litter box.

It might also explain why she was found wandering the neighborhood even though she had a bell and collar on. Its possible the previous owner just turned her outside because they didnt want to deal with her urinary problems anymore.

Dallas Henderson

Dear Dallas,

I asked Bonnie Beaver, professor at Texas A&M Veterinary Medicine, for the answer.

There are many reasons a cat does not use a litter box. The short tail of the Manx can be associated with this problem, she said.

If really short, there are abnormalities of the spinal column that affect nerves going to the urinary bladder and sometimes the rectum. They are much like people with spina bifida, in this regard. Affected Manx cats usually have little control and so dribble urine. It could appear that they dont use the litter box, but it is because their bladder really doesnt fill up. The urine that is not in the box would tend to be small amounts in several locations, not larger amounts in one location.

If the cat was using one or two locations away from the litter box instead, it was likely associated with the more typical causes of house soiling.

So youre correct. It could be part of the problem. Thanks for writing.

Dear Cathy,

About a month ago, I noticed a cat living under the garden shed. She was a trap/neuter/release cat with a clipped ear.

She was friendly, so we took her in and set her up in a room until she got used to the other cats. My son put poop from the other cat boxes in her box. She sniffed and figured out that is where she is supposed to go. Smart cat.

She is now known as Lucy instead of Clippy the Second.

Norm

Dear Norm,

Proof that a clipped ear (TNR) cat is sometimes a very friendly cat. Thanks for giving her a home.

Send your pet questions, tips and stories to cathy@petpundit.com. You can read her Animals Matter blog at http://blog.mysanantonio.com/animals and follow her at @cathymrosenthal.

The rest is here:
Cats with stubbed tails more prone to litter box issues - San Antonio Express-News

Read More...

Detective granted game-changing warrant to search genetic database – The Independent

November 8th, 2019 10:48 am

For police officers in the US, the genetic profiles that 20 million people have uploaded to consumer DNA sites represent a tantalising resource that could be used to solve cases both new and cold.

But for years, the vast majority of the data have been off-limits to investigators.

The two largest sites, Ancestry.com and 23andMe, have long pledged to keep their users genetic information privateand a smaller one, GEDmatch, severely restricted police access to its records this year.

Sharing the full story, not just the headlines

However, a Florida detective announced at a police convention that he had obtained a warrant to penetrate GEDmatch and search its full database of nearly 1 million users. Legal experts said that this appeared to be the first time a judge had approved such a warrant, and the development could have profound implications for genetic privacy.

Thats a huge game-changer, explainedErin Murphy, a law professor at New York University. The company made a decision to keep law enforcement out, and thats been overridden by a court. Its a signal that no genetic information can be safe.

Jackdaws can identify dangerous humans from listening to each others warning calls, scientists say. The highly social birds will also remember that person if they come near their nests again, according to researchers from the University of Exeter. In the study, a person unknown to the wild jackdaws approached their nest. At the same time scientists played a recording of a warning call (threatening) or contact calls (non-threatening). The next time jackdaws saw this same person, the birds that had previously heard the warning call were defensive and returned to their nests more than twice as quickly on average.

Getty

The sex of the turtle is determined by the temperatures at which they are incubated. Warm temperatures favour females.But by wiggling around the egg, embryos can find the Goldilocks Zone which means they are able to shield themselves against extreme thermal conditions and produce a balanced sex ratio, according to the new study published in Current Biology journal

Ye et al/Current Biology

African elephant poaching rates have dropped by 60 per cent in six years, an international study has found. It is thought the decline could be associated with the ivory trade ban introduced in China in 2017.

Reuters

Scientists have identified a four-legged creature with webbed feet to be an ancestor of the whale. Fossils unearthed in Peru have led scientists to conclude that the enormous creatures that traverse the planets oceans today are descended from small hoofed ancestors that lived in south Asia 50 million years ago

A. Gennari

A scientist has stumbled upon a creature with a transient anus that appears only when it is needed, before vanishing completely. Dr Sidney Tamm of the Marine Biological Laboratory could not initially find any trace of an anus on the species. However, as the animal gets full, a pore opens up to dispose of waste

Steven G Johnson

Feared extinct, the Wallace's Giant bee has been spotted for the first time in nearly 40 years. An international team of conservationists spotted the bee, that is four times the size of a typical honeybee, on an expedition to a group of Indonesian Islands

Clay Bolt

Fossilised bones digested by crocodiles have revealed the existence of three new mammal species that roamed the Cayman Islands 300 years ago. The bones belonged to two large rodent species and a small shrew-like animal

New Mexico Museum of Natural History

Scientists at the University of Maryland have created a fabric that adapts to heat, expanding to allow more heat to escape the body when warm and compacting to retain more heat when cold

Faye Levine, University of Maryland

A study from the University of Tokyo has found that the tears of baby mice cause female mice to be less interested in the sexual advances of males

Getty

The Intergovernmental Panel on Climate Change has issued a report which projects the impact of a rise in global temperatures of 1.5 degrees Celsius and warns against a higher increase

Getty

The nobel prize for chemistry has been awarded to three chemists working with evolution. Frances Smith is being awarded the prize for her work on directing the evolution of enzymes, while Gregory Winter and George Smith take the prize for their work on phage display of peptides and antibodies

Getty/AFP

The nobel prize for physics has been awarded to three physicists working with lasers. Arthur Ashkin (L) was awarded for his "optical tweezers" which use lasers to grab particles, atoms, viruses and other living cells. Donna Strickland and Grard Mourou were jointly awarded the prize for developing chirped-pulse amplification of lasers

Reuters/AP

The Ledumahadi Mafube roamed around 200 million years ago in what is now South Africa. Recently discovered by a team of international scientists, it was the largest land animal of its time, weighing 12 tons and standing at 13 feet. In Sesotho, the South African language of the region in which the dinosaur was discovered, its name means "a giant thunderclap at dawn"

Viktor Radermacher / SWNS

Scientists have witnessed the birth of a planet for the first time ever. This spectacular image from the SPHERE instrument on ESO's Very Large Telescope is the first clear image of a planet caught in the very act of formation around the dwarf star PDS 70. The planet stands clearly out, visible as a bright point to the right of the center of the image, which is blacked out by the coronagraph mask used to block the blinding light of the central star.

ESO/A. Mller et al

Layers long thought to be dense, connective tissue are actually a series of fluid-filled compartments researchers have termed the interstitium. These compartments are found beneath the skin, as well as lining the gut, lungs, blood vessels and muscles, and join together to form a network supported by a mesh of strong, flexible proteins

Getty

Working in the Brazilian state of Mato Grosso, a team led by archaeologists at the University of Exeter unearthed hundreds of villages hidden in the depths of the rainforest. These excavations included evidence of fortifications and mysterious earthworks called geoglyphs

Jos Iriarte

More than one in 10 people were found to have traces of class A drugs on their fingers by scientists developing a new fingerprint-based drug test.Using sensitive analysis of the chemical composition of sweat, researchers were able to tell the difference between those who had been directly exposed to heroin and cocaine, and those who had encountered it indirectly.

Getty

The storm bigger than the Earth, has been swhirling for 350 years. The image's colours have been enhanced after it was sent back to Earth.

Pictures by: Tom Momary

Included in Wellcome Image Awards, this 3D image of an African grey parrot shows the highly intricate system of blood vessels.

Scott Birch. Wellcome Images

Another Wellcome Images Award winner, this time of baby Hawaiian bobtail squid. The black ink sac and light organ in the centre of the squids mantle cavity can be clearly seen.

Macroscopic Solutions. Wellcome Images

Jackdaws can identify dangerous humans from listening to each others warning calls, scientists say. The highly social birds will also remember that person if they come near their nests again, according to researchers from the University of Exeter. In the study, a person unknown to the wild jackdaws approached their nest. At the same time scientists played a recording of a warning call (threatening) or contact calls (non-threatening). The next time jackdaws saw this same person, the birds that had previously heard the warning call were defensive and returned to their nests more than twice as quickly on average.

Getty

The sex of the turtle is determined by the temperatures at which they are incubated. Warm temperatures favour females.But by wiggling around the egg, embryos can find the Goldilocks Zone which means they are able to shield themselves against extreme thermal conditions and produce a balanced sex ratio, according to the new study published in Current Biology journal

Ye et al/Current Biology

African elephant poaching rates have dropped by 60 per cent in six years, an international study has found. It is thought the decline could be associated with the ivory trade ban introduced in China in 2017.

Reuters

Scientists have identified a four-legged creature with webbed feet to be an ancestor of the whale. Fossils unearthed in Peru have led scientists to conclude that the enormous creatures that traverse the planets oceans today are descended from small hoofed ancestors that lived in south Asia 50 million years ago

A. Gennari

A scientist has stumbled upon a creature with a transient anus that appears only when it is needed, before vanishing completely. Dr Sidney Tamm of the Marine Biological Laboratory could not initially find any trace of an anus on the species. However, as the animal gets full, a pore opens up to dispose of waste

Steven G Johnson

Feared extinct, the Wallace's Giant bee has been spotted for the first time in nearly 40 years. An international team of conservationists spotted the bee, that is four times the size of a typical honeybee, on an expedition to a group of Indonesian Islands

Clay Bolt

Fossilised bones digested by crocodiles have revealed the existence of three new mammal species that roamed the Cayman Islands 300 years ago. The bones belonged to two large rodent species and a small shrew-like animal

New Mexico Museum of Natural History

Scientists at the University of Maryland have created a fabric that adapts to heat, expanding to allow more heat to escape the body when warm and compacting to retain more heat when cold

Faye Levine, University of Maryland

A study from the University of Tokyo has found that the tears of baby mice cause female mice to be less interested in the sexual advances of males

Getty

The Intergovernmental Panel on Climate Change has issued a report which projects the impact of a rise in global temperatures of 1.5 degrees Celsius and warns against a higher increase

Getty

The nobel prize for chemistry has been awarded to three chemists working with evolution. Frances Smith is being awarded the prize for her work on directing the evolution of enzymes, while Gregory Winter and George Smith take the prize for their work on phage display of peptides and antibodies

Getty/AFP

The nobel prize for physics has been awarded to three physicists working with lasers. Arthur Ashkin (L) was awarded for his "optical tweezers" which use lasers to grab particles, atoms, viruses and other living cells. Donna Strickland and Grard Mourou were jointly awarded the prize for developing chirped-pulse amplification of lasers

Reuters/AP

The Ledumahadi Mafube roamed around 200 million years ago in what is now South Africa. Recently discovered by a team of international scientists, it was the largest land animal of its time, weighing 12 tons and standing at 13 feet. In Sesotho, the South African language of the region in which the dinosaur was discovered, its name means "a giant thunderclap at dawn"

Viktor Radermacher / SWNS

Scientists have witnessed the birth of a planet for the first time ever. This spectacular image from the SPHERE instrument on ESO's Very Large Telescope is the first clear image of a planet caught in the very act of formation around the dwarf star PDS 70. The planet stands clearly out, visible as a bright point to the right of the center of the image, which is blacked out by the coronagraph mask used to block the blinding light of the central star.

ESO/A. Mller et al

Layers long thought to be dense, connective tissue are actually a series of fluid-filled compartments researchers have termed the interstitium. These compartments are found beneath the skin, as well as lining the gut, lungs, blood vessels and muscles, and join together to form a network supported by a mesh of strong, flexible proteins

Getty

Working in the Brazilian state of Mato Grosso, a team led by archaeologists at the University of Exeter unearthed hundreds of villages hidden in the depths of the rainforest. These excavations included evidence of fortifications and mysterious earthworks called geoglyphs

Jos Iriarte

More than one in 10 people were found to have traces of class A drugs on their fingers by scientists developing a new fingerprint-based drug test.Using sensitive analysis of the chemical composition of sweat, researchers were able to tell the difference between those who had been directly exposed to heroin and cocaine, and those who had encountered it indirectly.

Getty

The storm bigger than the Earth, has been swhirling for 350 years. The image's colours have been enhanced after it was sent back to Earth.

Pictures by: Tom Momary

Included in Wellcome Image Awards, this 3D image of an African grey parrot shows the highly intricate system of blood vessels.

Scott Birch. Wellcome Images

Another Wellcome Images Award winner, this time of baby Hawaiian bobtail squid. The black ink sac and light organ in the centre of the squids mantle cavity can be clearly seen.

Macroscopic Solutions. Wellcome Images

DNA policy experts said the development was likely to encourage other agencies to request similar search warrants from 23andMe, which has 10 million users, and Ancestry.com, which has 15 million.

If that comes to pass, the Florida judges decision will affect not only the users of these sites but also huge swaths of the population, including those who have never taken a DNA test. Thats because this emerging forensic technique makes it possible to identify a DNA profile even through distant family relationships.

Using public genealogy sites to crack cold cases had its breakthrough moment in April 2018, when California police used GEDmatch to identify a man they believe is the Golden State Killer, Joseph James DeAngelo.

After his arrest, dozens of law enforcement agencies around the country rushed to apply the method to their own cases. Investigators have since used genetic genealogy to identify suspects and victims in more than 70 cases of murder, sexual assault and burglary, ranging from five decades to just a few months old.

Most users of genealogy services have uploaded their genetic information in order to find relatives, learn about ancestors and get insights into their health not anticipating that police might one day search for killers and rapists in their family trees.

After a revolt by a group of prominent genealogists, GEDmatch changed its policies in May. It required law enforcement agents to identify themselves when searching its database, and it gave them access only to the profiles of users who had explicitly opted in to such queries. (As of last week, according to GEDmatch co-founder Curtis Rogers, just 185,000 of the sites 1.3 million users had opted in.)

Only the best news in your inbox

Like many others in law enforcement, Detective Michael Fields of the Orlando Police Department was disappointed by GEDmatchs policy shift. He had used the site last year to identify a suspect in the 2001 murder of a 25-year-old woman, a case he had spent six years trying to solve. Today, working with a forensic consulting firm, Parabon, Mr Fields is trying to solve the case of a serial rapist who assaulted a number of women decades ago.

In July, he asked a judge in the 9th Judicial Circuit Court of Florida to approve a warrant that would let him override the privacy settings of GEDmatchs users and search the sites full database of 1.2 million users.

After Judge Patricia Strowbridge agreed, the site complied within 24 hours. He said that some leads had emerged but that he had yet to make an arrest. He declined to share the warrant or say how it was worded.

Mr Fields described his methods at the International Association of Chiefs of Police conference in Chicago last week. Logan Koepke, a policy analyst at Upturn, a nonprofit in Washington that studies how technology affects social issues, was in the audience. After the talk, multiple other detectives and officers approached him asking for a copy of the warrant, Mr Koepke said.

DNA policy experts said they would closely watch public response to news of the warrant, to see if law enforcement agencies will be emboldened to go after the much larger genetic databases. I have no question in my mind that if the public isnt outraged by this, they will go to the mother lode: the 15-million person Ancestry database, Ms Murphy said. Why play in the peanuts when you can go to the big show?

Woman conceived by rape of her 13-year-old mother wants DNA test to prosecute father: Im a walking crime scene

Yaniv Erlich, chief science officer at MyHeritage, a genealogy database of around 2.5 million people, agreed. They wont stop here, he said.

Excerpt from:
Detective granted game-changing warrant to search genetic database - The Independent

Read More...

US varsity to collaborate with AIIMS, KMC on genetics – Deccan Herald

November 8th, 2019 10:48 am

A top American university will expand genetic testing in India in partnership with the All India Institute of Medical Sciences in Delhi and the Kasturba Medical College in Manipal.

A $2.3 million grant from the National Institute of Health over five years will help the University of Michigan and Indian geneticists identify and confirm genetic changes that are the basis of developmental disorders.

Noting that seven out of 10 children with developmental disorders in India do not receive genetic testing, the university, in a media release on Wednesday, said the study hopes that with greater access to genetic testing, children with developmental disorders of genetic origin will be more likely to receive a molecularly confirmed diagnosis.

"An accurate molecular diagnosis can dramatically improve care management of individuals with rare developmental disorders and involved treatments," Stephanie Bielas, associate professor of human genetics at the U-M Medical School, said.

"Without a genetic diagnosis, individuals with rare disorders can incur inappropriate care and medical procedures," she said.

Advanced genetic tests like exome sequencing are often out of reach of many Indian patients because of the cost, and it often requires a multidisciplinary group of experts.

Bielas, the university said, has been working with her partners in AIIMS and Manipal, a city in the southern state of Karnataka for the last four years, building on the technological and organisational infrastructure needed to improve access to genetic testing.

During this time, they have identified sequencing partners, developed the platforms needed to analyse sequence data, and trained teams who can interpret the sequence and go back to the families with the results.

Integrating genetic counselling into the continuum of genetic testing is an important part of increasing access to genetic testing, Bielas said.

"It is only when the families understand the results of the genetic test and the risk for recurrence that the benefits of genetic testing for families and communities are realised," she said.

India is home to 1.3 billion people and represents 20 per cent of the world's population. But less than one per cent of the genomic data used for research comes from this region.

Researchers hope that uncovering this genetic diversity will provide a better understanding of the human genome and differences in the presentation of inherited developmental disorders, it said.

The researchers also want to establish an accessible database that can be shared with other scientists and institutions for research and to contribute to responsible development of genomic medicine in India and beyond, the university said.

Read more from the original source:
US varsity to collaborate with AIIMS, KMC on genetics - Deccan Herald

Read More...

Genetic testing leads woman to take steps to avoid breast cancer: Im one of the lucky ones – WITI FOX 6 Milwaukee

November 8th, 2019 10:48 am

Please enable Javascript to watch this video

MILWAUKEE -- The earlier you catch breast cancer, the better your odds are of beating it. That is the idea behind the FOX6 initiative, Buddy Check 6.

Birthdays are a time to celebrate -- especially the big ones like turning 30 years old -- which is what Antonina Sendik was doing last month.

"I'm one of the lucky ones," Sendik said.

In fact, you might say Sendik is just starting her life.

"It's been a very emotional six months," Sendik said.

Sendik's father has had two brain tumors and was recently diagnosed with a disease called Cowden's Syndrome. It is a red flag that Sendik and her five siblings may have inherited the gene mutation that can cause a host of health problems. Doctors recommended genetic testing. They found Sendik had an 86 percent chance of developing breast cancer.

"I had no symptoms. I felt fine besides what was on the inside," Sendik said. "We started talking then about -- I'm probably going to have a double mastectomy."

Sendik learned that reality just a few months ago.

"You never think this is going to happen to you or this can't happen to me," Sendik said. "I would have loved to have blown it off. Learning that risk, I had no choice.

Sendik's doctor felt the same.

"With the genetic mutation, we knew that the risk was there," Dr. Caitlin Patten said.

"She said my job is to keep you safe -- and that's what I'm going to do," Sendik said.

With that, Sendik decided to go through with the surgery. It was a success. Post-surgery, the breast tissue that was removed was tested.

"So there were cancer cells. But it hadn't broken outside the duct -- it hadn't spread anywhere," Sendik said.

Sendik was relieved.

"She got it, it's gone, it's out of me," Sendik said.

Sendik does not need radiation or chemotherapy because the cancer is gone. She just needs to maintain a healthy lifestyle -- and keep regular appointments with her doctor.

Follow this link:
Genetic testing leads woman to take steps to avoid breast cancer: Im one of the lucky ones - WITI FOX 6 Milwaukee

Read More...

Surge in number of healthy patients who want genetic testing to find risk of cancer – Independent.ie

November 8th, 2019 10:48 am

Surge in number of healthy patients who want genetic testing to find risk of cancer

Independent.ie

Growing numbers of healthy people are on waiting lists for months to find out if they have inherited genes which leave them at a higher risk of some cancers, it emerged yesterday.

https://www.independent.ie/irish-news/health/surge-in-number-of-healthy-patients-who-want-genetic-testing-to-find-risk-of-cancer-38669341.html

https://www.independent.ie/irish-news/health/article38421846.ece/d571b/AUTOCROP/h342/ward-stock.jpg

Growing numbers of healthy people are on waiting lists for months to find out if they have inherited genes which leave them at a higher risk of some cancers, it emerged yesterday.

They are being referred for specialist screening because of their family history of certain forms of cancer.

However, they face the anxiety of delays to be seen because understaffed services in St James's Hospital in Dublin are struggling to cope.

Prof David Gallagher, a consultant in medical oncology and genetics, warned his clinic is now getting 7,800 referrals a year - around 150 a week - and this is leading to waiting lists.

He said his team expects to provide 4,000 test results this year - up from less than 500 in 2013 - but it cannot keep pace with demand.

The patients include those with a family history of particular cancers who want to know if they have inherited versions of the genes which leave them at increased risk.

The clinics are also dealing with a significant number of referrals of patients who have cancer and need to learn if they have a genetic mutation which would make them suitable for certain drug treatments.

A healthy patient who is referred today will be on a waiting list until May, said Prof Gallagher.

"A lot of the testing is urgent. We keep slots for urgent cases each week. If the testing will change the treatment of a cancer patient, we will get them in," he said.

However, it means that this pushes out the time faced by patients who need testing to show if they have a mutated gene which can increase their chance of getting cancer of the breast, ovary or prostate.

A positive result means the person with the inherited faulty versions of genes can take steps to manage and reduce their risk.

BRCA1 and BRCA2 - which actress Angelina Jolie inherited - are two of the best known examples of genes that raise a woman's risk of developing breast or ovarian cancer.

Prof Gallagher said the majority of women in Ireland who test positive for these genes still adopt a "watch and wait" approach, but there has been a rise in the numbers having preventive surgery.

These are not the only cancer risk genes, and there are many that people can now be screened for. "Five different genes cause Lynch syndrome," he pointed out.

Lynch syndrome is a genetic condition that can significantly increase the risk of developing bowel cancer, as well as cancer of the womb and ovary.

The only clinics for public patients who need genetic testing are in St James's Hospital and Crumlin Hospital.

Prof Gallagher said his service is "hugely under-staffed" and there is an urgent need for more consultant cancer geneticists and counsellors.

A new cancer geneticist will join the team from New York next year, but it will remain under huge pressure. He said there is also a need for Ireland to develop its own molecular genetics lab. Currently samples are sent abroad for testing, which adds to the delay.

Prof Gallagher will be among the speakers at a conference in St James's Hospital today. The Trinity-St James's Cancer Institute will unveil a sculpture by Chris Wilson to mark the 25th anniversary of the first time a woman was tested for the BRAC2 gene in Ireland.

Irish Independent

Read more:
Surge in number of healthy patients who want genetic testing to find risk of cancer - Independent.ie

Read More...

Genetic testing at UVMMC aims to improve patient care – Local 22/44 News

November 8th, 2019 10:47 am

New testing at the University of Vermont Medical Center will help determine the role DNA plays in your health.

We want to improve peoples lives, said Dr. Debra Leonard, chair of Pathology and Laboratory Medicine at the University of Vermont Medical Center.

For the past year and a half, shes been working along with a team of physicians and specialists to develop Genomic DNA Testing.

It really is to integrate genetic information into routine medical care, she said.

Dr. Leonard said that information can be very helpful in improving outcomes for patients if they know their disease risk in advance. The testing will allow patients to learn about differences in their DNA that can make certain diseases more likely.

What we will be focusing on is diseases related to the heart and diseases related to cancer risk, Dr. Leonard said.

UVM Health Network is partnering with Invitae and LunaPBC on the project which will provide information on nearly 150 genes that are indicators for illnesses. The goal is to recognize if a patient is at risk for one of those diseases before they actually experience their first symptom, allowing doctors to intervene early and make informed decisions.

So we can use preventive strategies or close monitoring to catch the diseases earlier or even implement strategies to prevent the diseases, she said.

Right now, the testing is in its beginning phases. Last Friday, it was offered to the first patient, who agreed to have their blood drawn and sent out for testing, fully funded by the department. Over the next year, UVMMC is aiming to test 1,000 patients ages 18 and older.

See the rest here:
Genetic testing at UVMMC aims to improve patient care - Local 22/44 News

Read More...

Costa Rica sets the foundations with development potential in the Fourth Industrial Revolution – Q Costa Rica News

November 8th, 2019 10:47 am

What is known as the Fourth Industrial Revolution will bring about the disappearance and transformation of thousands of jobs; At the same time, it will give great emphasis to information and communication technologies.

However, there will be other areas with great potentials, such as biotechnology and medical research, where Costa Rica could become a hub in the future if it seizes the opportunity.

Costa Rica has the human talent to carry it out and to initiate a bioreactivation of the economy; However, decision-makers have not yet seen the opportunity, says Miguel Rojas, a researcher at the Biotechnology Research Center of the Instituto Tecnolgico de Costa Rica (Technological Institute of Costa Rica).

And in this area of science, innovative technologies such as precision and regenerative medicine will be applied, as well as tissue engineering and RNA and stem cell-based therapies.

Immunotherapy and advanced diagnoses would also have a place in this wave of job creation and economic recovery.

The engineers and biotechnology engineers (IBio) of the TEC have the appropriate training and ability to work with these methodologies. The paradox, in this case, is that the country has the human talent for these new processes, but the decision-makers at the political, business or financial level have not realized this enormous possibility for the country, said Rojas.

Currently, there are 608 TEC graduates, which represent one in 40 applicants who wanted to study it, so the system itself guarantees the excellence of human talent.

On the other hand, it is estimated that about 20 million medical tourism patients every year, according to the specialized guide of Patients Beyond Borders.

One of the biggest demand for this business is from Americans, with some 1.9 million traveling outside their borders to receive medical care.

Costa Ricas proximity to the United States, cost and human talent make it competitive; In 2018, more than 15,000 people identified health care as their main reason for travel, to the country according to the Instituto Costarricense de Turismo (ICT) Costa Rican Tourism Board so there is plenty of room to grow.

As for medical research, biotechnology would have multiple applications in the future, says the Organization for Economic Cooperation and Development (OECD).

Costa Rica has a great opportunity in clinical research for us to sell or develop sponsored by pharmaceutical houses or with medical equipment producers, taking advantage of the presence in the country of multinationals, said Massimo Manzi, executive director of the Cmara Costarricense de la Salud (Promed) Costa Rican Chamber of Health.

In this way, the country would not only receive designs and produce them, but it would also be fully involved in all the stages of research, development and pre-commercialization of clinical studies.

The Biotechnology career has high expectations, according to the TEC that receives 1,664 applications per year (2016-2018), but only 40 per year are accepted. As of March 2018, the school reports 556 graduates, of which 60% are women, which have potential work in 20 countries on four continents.

Survivors of the revolution

The International Monetary Fund (IMF) said that the robotization of sectors of the economy would displace more than 7 million jobs in the 17 most important economies in the world by 2020.

However, several careers will have a high demand and are the following:

La Repblica reports in Spanish.

Read more from the original source:
Costa Rica sets the foundations with development potential in the Fourth Industrial Revolution - Q Costa Rica News

Read More...

Page 822«..1020..821822823824..830840..»


2025 © StemCell Therapy is proudly powered by WordPress
Entries (RSS) Comments (RSS) | Violinesth by Patrick