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Total Hip Arthroplasty for Secondary Causes of Arthritis An Increase in Time and Money – DocWire News

December 11th, 2019 11:41 pm

BACKGROUND:

Total hip arthroplasty (THA) is a frequently performed, highly successful orthopedic procedure. Although primary osteoarthritis (PA) is the most common reason for (THA), there are several secondary conditions that lead to degenerative hip disease that are successfully treated with THA. The purpose of this study was to examine the incidence of these secondary causes of arthritis (SA) leading to THA and to compare the relative surgical costs, operating times, and hospital length of stay (LOS) for THA done for PA versus SA.

Electronic medical records from 836 continuous patients undergoing primary THA over a 2-year period were reviewed at a single high-volume joint arthroplasty center. Data obtained included age, sex, laterality, diagnosis leading to THA, surgical costs based on hospital fees, operating room time, and hospital LOS. Using operative reports, office visit notes, and radiology reports or images, patients were categorized into PA or SA groupings. PA was defined as osteoarthritis of no other known etiology, whereas SA was defined when a known underlying diagnosis led to degenerative joint disease of the hip. SA included hip dysplasia, post-traumatic arthritis (PTA), avascular necrosis (AVN), inflammatory arthropathy, Perthes disease, and slipped capital femoral epiphysis (SCFE). Means and proportions of the variables from both groups were analyzed and compared using t-tests and chi-squared tests where applicable.

There were 599 patients in the PA group and 237 patients in the SA group. The SA group was significantly younger than the PA group (54.4 years versus 64.0 years; p = 0.0001). The SA cohort had significantly higher mean surgical costs ($29,662 versus $27,078; p = 0.0005), operating room times (189 minutes versus 179 minutes; p = 0.0042), and LOS (4.2 days versus 3.9 days; p = 0.0312). Within the SA group, the hip dysplasia subgrouping had the lowest cost and operating room time, whereas the PTA subgrouping had the highest cost and operating room time.

More than a quarter of primary THAs are performed due to secondary arthritis, most commonly due to hip dysplasia. Cases of THA due to secondary arthritis are associated with significantly increased hospital costs, operating time, and postoperative length of stay compared to THAs performed for primary osteoarthritis. Patients with post-traumatic hip arthritis may contribute the highest economic burden and present the most complex cases for arthroplasty surgeons.

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Severe Pneumonia in Finnish Children With JIA Has Decreased Over Time, Study Shows – Juvenile Arthritis News

December 11th, 2019 11:41 pm

Despite a higher overall frequency of pneumonia and greater use of immunosuppressive therapies, the occurrence of serious pneumonias has decreased in Finnish children with juvenile idiopathic arthritis(JIA) over time, a study shows.

The researchers hypothesized that this may reflect better clinical care and early detection of lung infections in these children.

The work also suggested that active JIA, the presence of comorbidities, or simultaneous diseases, and receiving combination therapy may be associated with an increased risk of developing pneumonia. However, there was no link between the use of immunosuppressants and pneumonia severity.

The study, Decreasing trend in the incidence of serious pneumonias in Finnish children with juvenile idiopathic arthritis, was published in the journal Clinical Rheumatology.

The main treatment goals in JIA today include achieving inactive disease as early as possible in childrens lives and preventing joint damage caused by inflammation. The development of disease-modifying anti-rheumatic drugs (DMARDs) which are designed to block inflammation has significantly improved the lives of children with JIA.

Yet, the immune system suppression that occurs with standard JIA medications, such as DMARDs and glucocorticoids along with the disease itself and the presence of comorbidities have been associated with an increased risk of infections in these children.

A recent analysis of the 15-year period between 1999 and 2014 showed that pneumonia one of the most common serious infections in JIA patients has become more frequent in Finnish children with the disease. That increase has been mirrored by a significant jump in the use of DMARDs in this patient population during the same time period.

Now, that same team of researchers set out to determine the severity of pneumonia in these children, and whether it was associated with the use of immunosuppressive therapy.

The team analyzed data from 59,048 JIA patient-years a measure obtained by multiplying the number of persons per time between 1998 and 2014, using a national patient registry that covers the entire hospital network in Finland. The number of children with JIA per year in the registry varied between 2,292 and 3,575 from 1998 through 2006, and between 3,633 and 4,511 in the years 2007 to 2014.

Pneumonia was classified as serious if the child was hospitalized or given antibiotics directly into the bloodstream. It was deemed hospital-acquired if the illness developed 48 hours or later following hospital admission for reasons other than lung infection.

The results showed 157 pneumonia episodes of which 111 (70.7%) were serious in 140 children with JIA. Only one case was hospital-acquired.

The mean age of children with at least one pneumonia episode was 9.4 years; 83 (59.3%) of the children were girls. Most had either oligoarthritis (45%) or polyarthritis (45.7%).

The rate of serious pneumonia decreased from the first time period 1998 through 2006 to the second, from 20072014. The team hypothesized that this trend may be a result of better contact between patients and the health care system, which would promote earlier detection and treatment of lung infections.

It is also worth noting that a decrease in pneumonia rates has been reported after introduction of pneumococcal vaccination into the Finnish national vaccination program in 2010, the researchers said.

Data also showed that nearly half of the children with pneumonia had active disease, comorbidities with asthma (17.9%) and Down syndrome (7.1%) being the most common and were receiving combination therapy.

At the time of the pneumonia episodes, 86% of the children were receiving DMARDs, with 61.8% receiving methotrexate and 25.8% taking TNF inhibitors. This inhibitors block the activity of TNF-alpha, a pro-inflammatory molecule.

Among the children treated, 15 (10.7%) had recurrent pneumonias; 12 of them had comorbidities. Patients were taking DMARDs during 28 of the 32 (87.5%) recurrent pneumonia episodes.

The team noted that they found no significant association between pneumonia severity and the use of DMARDs or glucocorticoids.

The data showed that, overall, active JIA, comorbidities and combination medication were associated with nearly half of the pneumonias, the researchers said.

Still, future studies are required to confirm these findings and to evaluate the potential association between pneumonia and specific types of JIA, they added.

Clinicians should always keep in mind the possibility of serious infectious complications in these immunocompromised patients, the investigators said.

Less Severe Pneumonias Over Time in Finnish Children With JIA, Study Shows

Marta Figueiredo holds a BSc in Biology and a MSc in Evolutionary and Developmental Biology from the University of Lisbon, Portugal. She is currently finishing her PhD in Biomedical Sciences at the University of Lisbon, where she focused her research on the role of several signalling pathways in thymus and parathyroid glands embryonic development.

Total Posts: 11

Jos is a science news writer with a PhD in Neuroscience from Universidade of Porto, in Portugal. He has also studied Biochemistry at Universidade do Porto and was a postdoctoral associate at Weill Cornell Medicine, in New York, and at The University of Western Ontario in London, Ontario, Canada. His work has ranged from the association of central cardiovascular and pain control to the neurobiological basis of hypertension, and the molecular pathways driving Alzheimers disease.

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Mahesh Bhatt: More interested in the longevity of my films than by their debut grosses – Hindustan Times

December 11th, 2019 10:47 am

Filmmaker Mahesh Bhatt says he is more interested in the longevity of his films than by their debut grosses. Mahesh on Wednesday took to Twitter, where he shared a poster of his film Zakhm, which was released 21 years.

He wrote: I am more interested in the longevity of my films than by their debut grosses. I ask does it have anything to say in 10 years or 20 years? Could it still have legs? Could it still be around? History is rife with films that we love today that were bombs on their opening weekend.

Zakhm is considered of Bhatts finest directorial efforts and is said to bear autobiographical shades. The film won Ajay Devgn a National Award as Best actor, and also featured Pooja Bhatt, Sonali Bendre, Nagarjuna, and Kunal Kemmu as a child artist. The film won the Nargis Dutt Award for Best Feature Film on National Integration.

Also read: Deepika Padukones Chhapaak trailer earns praise from acid attack survivor Rangoli Chandel

Alia Bhatt accompanied by her father Mahesh Bhatt, addresses at the launch of her sister Shaheen Bhatt's book I've Never Been (un)Happier.(IANS)

Bhatt on Wednesday announced that he is venturing into the digital space with a web-series based on the relationship of a struggling filmmaker and a top female actor in the 70s.

Follow @htshowbiz for more

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Study Reveals How Planning For The Future May Help With Longevity – mindbodygreen.com

December 11th, 2019 10:47 am

Being a planner can set you up for success in every phase of life. For example, students who set goals are more likely to see improvements in academic performance, and older people aiming to adopt healthier lifestyles can reduce the effects of dementia. According to a new study, planning for the futureeven in the face of terminal illnesscan prolong life for up to one year.

The study, published in the journal BMJ Supportive & Palliative Care, found that patients who are terminally ill might live longer if they discuss advance care options with doctors.

Planning for advance care is a process between patients and health professionals, in which possible treatments, priorities, and desires for impending care are discussed. This is especially useful for doctors who have to choose whether or not to continue treatment when patients lose the ability to communicate.

In this particular study, researchers looked at the death dates of 205 patients with terminal illnesses, including advanced cancers, as well as heart and lung diseases. Of the patients, 102 had disclosed their advance care preferences while 103 did not.

Of the group who engaged in these conversations, 90% with lung and heart diseases lived beyond the next year. This was compared to 67% who did not talk to their doctors about the future. The outcomes of patients with cancer were not affected.

Until now, the connection between advance care discussions and longevity were unexplored. This research can provide hope for people who are diagnosed with progressive, terminal diseases and their families, who might get more time with loved ones.

The analysis was explorative, and more research needs to be done to find conclusive evidence, but researchers did suggest a possible reason for the increase in survival rates. "This type of conversation helps these patients better understand the life-limiting nature of their illness," a news release said. Recognizing the severity of these illnesses could make patients more willing to accept treatment.

The underlying message of these findings could be helpful for anyone, regardless of health. Finding a purpose has been known to improve mental and physical well-being, and that fact now holds true in the face of death.Perhaps discussing the future, in any capacity, can make it feel less out of reach.

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Sanofi to restructure its Onduo, Verily partnership alongside diabetes exit – FierceBiotech

December 11th, 2019 10:46 am

As its new CEO begins to move Sanofi away from new diabetes research, the drugmakerand producer of one of the worlds top-selling insulinswill also look to pull back from its three-year-old relationship with Verily and their virtual diabetes clinic, Onduo.

The restructuring comes shortly after the joint venture celebrated the completion of its expansion across the continental U.S., announcing that it now offers counseling services in 49 states. In addition, Onduo recently published a promising real-world evidence study showing gains in glucose control among type 2 diabetes patients with high blood sugar.

The virtual diabetes venture was first launched in September 2016 with nearly $500 million in equal investments from the French Big Pharma and Googles life science-focused sister company Verily.

How ICON, Lotus, and Bioforum are Improving Study Efficiency with a Modern EDC

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Now, newly installed chief Paul Hudson aims to refocus the company on its strongest products in immunology and vaccines, while discontinuing its R&D programs in diabetes and cardiovascular diseases following struggling sales. All in all, the drugmaker hopes to save 2 billion, or $2.2 billion U.S., by 2022.

RELATED: Sanofi CEO Hudson backs away from struggling diabetes, cardiovascular areas in strategy unveiling

In a capital markets day presentation to pitch its new strategy, Sanofi said it would direct its cashflow from diabetes and cardiovascular treatments to already mature markets. It would also halt the planned launch of efpeglenatide, a GLP-1 injection for Type 2 diabetes, and instead seek a partner to take over its commercialization.

Regarding Onduo, Hudson said the company over-invested in the project in the past. Sanofi will stay on as a financial backer, but wont be involved in its ongoing operations, according to reports.

RELATED: Sanofi, Verily and Sensile to build all-in-one insulin patch pump

Whether this means more independence for Onduo remains to be seen. In late November, the virtual clinic amended its collaboration and license agreement with diabetes hardware maker Dexcom, making it the ventures preferred supplier of continuous glucose monitoring devices for its Type 2 diabetes program.

In return, Dexcom inked a $250 million upfront payment in shares of common stock, and signed on to additional payments of $280 million linked to future product launches and sales milestones. In addition, Dexcom and Verily expanded their collaboration options for new products and software, including programs for Dexcoms CGM systems.

Onduos smartphone-based clinic officially launched in early 2018, which aims to connect patients with its own network of board-certified endocrinologists to guide lifestyle and medication changes and track potential long-term complications of diabetes.

Last week, Onduo published real-world data gathered from 740 of its participants, showing that 92% of those with the highest starting HbA1c saw decreases of 2.3 percentage points through the telehealth programfrom an average of 10.7% down to 8.3%.

The data was taken from users from 21 U.S. states, with 30% living in rural communities. Nearly half of the participants were remotely prescribed and shipped CGMs during the study, according to Onduo. The results were published in the Journal of Diabetes Science and Technology.

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People Living With Type 2 Diabetes Want Information and Empathy From Their Doctors More Than New Medications – BioSpace

December 11th, 2019 10:46 am

SAN FRANCISCO, Dec. 10, 2019 /PRNewswire/ --MyHealthTeams, creator of the largest and fastest-growing social networks for people facing chronic health conditions, today unveiled new research conducted among the more than 100,000 registered members of DiabetesTeam, the social network for people living with Type 2 Diabetes. A majority (59%) of those surveyed report they are either not satisfied or only somewhat satisfied with their current treatment. Yet when asked what they most want from their doctor, only 6% said "new treatments." More than 7 times as many respondents prioritized wanting their endocrinologist to provide "more information" on recommended lifestyle changes (22%) and "listening and understanding" about the challenges of managing their diabetes (21%).

The issue is not a lack of understanding about the importance of lifestyle changes. The gap is in getting practical tips for successfully adopting lifestyle changes -- especially in the context of dealing with the wide-ranging impact diabetes has on daily life. MyHealthTeams identified two key areas in which people living with diabetes know they want to improve - but aren't sure what to do or how to start:

Quality of Life Impact

Beyond high blood sugar, people with Type 2 Diabetes report experiencing a wide range of symptoms of the disease in the past year, including:

The impact of diabetes on daily life is significant, with survey respondents reporting top challenges including:

"What's clear is that managing blood sugar is just one piece of the diabetes puzzle, and people living with this condition are juggling a lot," said Eric Peacock, cofounder and CEO of MyHealthTeams. "The call to action across the healthcare ecosystem is to empower consumers with information and support to act as their own health advocates within this context. People need practical advice and emotional empathy. It's about much more than medicine."

This research was conducted among the more than 100,000 registered members of DiabetesTeam. 478 individuals responded to the online survey. Full survey findings are available at https://www.diabetesteam.com/resources/the-results-are-in-what-people-with-type-2-diabetes-want-most-from-their-doctors-is-information-not-new-treatments.

About MyHealthTeamsMyHealthTeamsbelieves that if you are diagnosed with a chronic condition, it should be easy to find and connect with others like you. MyHealthTeams creates social networks for people living with a chronic health condition. Millions of people have joined one of the company's 34 highly engaged communities focusing on the following conditions: Crohn's and colitis, multiple sclerosis, lupus, fibromyalgia, pulmonary hypertension, spondylitis, eczema, myeloma, hyperhidrosis, rheumatoid arthritis, psoriasis, leukemia, lymphoma, irritable bowel syndrome, Parkinson's, Alzheimer's, epilepsy, hemophilia, hidradenitis suppurative, depression, heart disease, type 2 diabetes, osteoporosis, COPD, chronic pain, migraines, food allergies, obesity, HIV, PCOS, endometriosis, breast cancer and autism. MyHealthTeams' social networks are available in 13 countries.

View original content to download multimedia:http://www.prnewswire.com/news-releases/people-living-with-type-2-diabetes-want-information-and-empathy-from-their-doctors-more-than-new-medications-300972655.html

SOURCE MyHealthTeams

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Mothers With Diabetes, Kids With Heart Disease – Managed Care magazine

December 11th, 2019 10:46 am

Maternal diabetes before or during pregnancy is associated with increased risks of metabolic syndromeand congenital heart disease in offspring. Research has shown that the children of mothers with elevated blood sugar that is shy of level that would categorize them as havingof gestational diabetes are, nonetheless,more likely to be obese. But less is known about the associations between prenatal exposure to maternal diabetesand early-onset CVD in infants. So researchers from Aarhus University Hospital, Denmark, and University of California, Los Angeles, looked at data from nearly 2.5 million births to find out more. They reported their results on Dec. 4, 2019, on the BMJ website,

During up to 40 years of follow-up, 1,153 offspring of mothers with diabetes were diagnosed with CVD, as were 91,311 children of mothers without diabetes. The offspring of mothers with diabetes had a 29% increased overall rate of early-onset CVD.

Children of mothers with diabetes were also more likely to have diabetes, hypertension, hypercholesterolemia, and chronic kidney diseases, and to be obese. The rates of specific types of CVD were increased for heart failure, and close to doubled for hypertensive disease, deep vein thrombosis, and pulmonary embolism. A mother with diabetes and CVD herself also nearly doubled the offsprings chances of early-onset CVD.

The diabetic intrauterine environment could have a programming effect on the development of CVD in children, the researchers say. They note that during pregnancies complicated by diabetes, large amounts of maternal glucose freely cross the placenta, which could lead to increased secretion of fetal insulin. Exposure to hyperinsulinemia and hyperglycemia could have long-lasting effects, they say, and result in changes in vascular function. Their findings underscore the importance of screening for diabetes risks, especially in pregnant women, to avoid multigenerational hits to heart health.

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85-year-old man with Type 1 diabetes shatters expectations – WNDU-TV

December 11th, 2019 10:46 am

There are more than a million people who have Type 1 diabetes, and they're expected to live at least 10 years less than Americans without it.

In fact, there are only 90 diabetics who have lived more than 70 years.

But one man crushed that goal 15 years ago and is telling others how they can do it too.

Eighty-five-year-old Don Ray can't remember a life without diabetes.

As a child, Don could not go to gym class. He couldn't play sports. He couldn't even play hide and seek.

"Because if you were to hide, and they can't find you and you have an insulin reaction or a hypoglycemia, you might really be in trouble because they will never find you," Don explains.

He was told he wouldn't live past his 30s. But eventually he got tired of hearing, "You can't, you can't, you can't."

"I would go to gym class when I started school in kindergarten and first grade, and I'd sit in the chair in gym class and I'd watch these kids, and I knew I could do this, cause I just knew I could do this," Don says.

Don and his dad started playing catch, and that turned into 20 years of playing football and 30 years of baseball.

And he did it because "he followed the rules," according to Betul Hatipoglu, MD, at the Cleveland Clinic.

What rules? First make sure your blood sugar is in check: between 80 and 130 milligrams. If it's too low, eat some carbs, but don't forget to check while working out.

"If they are going to exercise for an hour, they have to check it in 30 minutes again to make sure they are still in the safe zone," Hatipoglu says.

But don't take too much insulin before your meal or before your workout.

"So if you are going to exercise after lunch, for lunch you take less insulin so it is safer for you," Hatipoglu says.

And if you're working out after dinner, be careful as well. You don't want any overnight complications.

"If you take care of the disease, the disease will take care of you, and you can if you take care of yourself," Hatipoglu explains.

Nowadays, there are nearly 140,000 people diagnosed with diabetes each year in the U.S. alone. But in 30 years, an expected five million Americans will be diagnosed with Type 1 diabetes.

DIABETES TYPE 1: DON SHATTERS EXPECTATIONS! REPORT #2699

BACKGROUND: Glucose is a critical source of energy for your brain, muscles, and tissues. When you eat, your body breaks down carbohydrates into glucose and this triggers the pancreas to release a hormone called insulin. Insulin acts as a "key" that allows glucose to enter the cells from the blood. Your body can't function or perform properly if it doesn't produce enough insulin to effectively manage glucose. This is what produces the symptoms of diabetes. Uncontrolled diabetes can lead to serious complications by damaging blood vessels and organs. It also increases the risk of heart disease, stroke, kidney disease, nerve damage, and eye disease. Nutrition and exercise help manage diabetes, but it's also important to track blood glucose levels. Treatment may include taking insulin or other medications. (Source: https://www.healthline.com/health/diabetes/facts-statistics-infographic#1)

COPING WITH TYPE 1 DIABETES: People who have had type 1 diabetes for a long time may develop what's called "diabetes burnout." This can happen when you start to feel burdened by the disease. A good support system is essential to coping with type 1 diabetes. Spending time with friends and family or talking with someone you trust are ways to manage diabetes distress, which can include stress and anxiety. Taking good care of yourself can reduce diabetes stress and help you cope with the condition. Making sure to eat well, exercise, and learn how to monitor blood sugar levels are important. Getting enough sleep each night and taking time to relax and enjoy life are also very important. There are resources available to help you manage type 1 diabetes such as apps designed to count carbs, watch blood sugar levels, and track progress with diet and exercise. The more you know about your condition, the better prepared you'll be at taking care of yourself. Your doctor can also recommend books about type 1 diabetes. (Source: https://www.healthline.com/health/type-1-diabetes/living-with-type-1/how-you-can-cope#4)

NEW DISCOVERY FOR DIABETES: Matthias Hebrok, PhD, director of the UCSF diabetes center, and Gopika Nair, PhD, have discovered how to transform human stem cells into healthy, insulin producing beta cells. "We can now generate insulin-producing cells that look and act a lot like the pancreatic beta cells you and I have in our bodies. This is a critical step towards our goal of creating cells that could be transplanted into patients with diabetes," said Dr. Hebrok. For the longest time, scientists could only produce cells at an immature stage that were unable to respond to blood sugar levels and secrete insulin properly. The team discovered that mimicking the "islet" formation of cells in the pancreas helped the cells mature. These cells were then transplanted into mice and found that they were fully functional, producing insulin and responding to changes in blood sugar levels. Dr. Hebrok's team is already in collaboration with various colleagues to make these cells transplantable into patients. (Source: https://blog.cirm.ca.gov/2019/02/05/breakthrough-for-type-1-diabetes-scientist-discovers-how-to-grow-insulin-producing-cells/)

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Type 2 diabetes: Drinking this type of tea could lower your blood sugar – Express

December 11th, 2019 10:46 am

We demonstrated that black tea reduced incremental blood glucose after sucrose consumption at 60, 90 and 120 minutes compared with placebo, wrote the authors of the study.

The data confirm that polyphenols lower glycemic response and may be responsible for the lower rates of diabetes observed with tea and coffee consumption, said Peter Clifton, M.D., PhD., professor of nutrition at the University of South Australia in Adelaide, who recently conducted a review of the role of dietary polyphenols (in tea, cinnamon, coffee, chocolate, pomegranate, red wine and olive oil, among others) in regulating glucose homeostasis and insulin sensitivity, which was published in Nutrients.

Echoing the findings, a study in mice compared the effects of black and green tea extract on blood sugar levels.

Results found that they both lowered blood sugar and improved how the body metabolised sugar.

Carbs with a low GI value are more slowly digested, absorbed and metabolised and cause a lower and slower rise in blood glucose and therefore insulin levels.

to the NHS, many people have type 2 diabetes without realising because symptoms do not necessarily make you feel unwell.

Symptoms include:

You should speak to your GP if you have any of the symptoms of type 2 diabetes or you're worried you may have a higher risk of getting it, advises the health body.

It added: The earlier diabetes is diagnosed and treatment started, the better. Early treatment reduces your risk of other health problems.

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Trial suggests fasting 14 hours a day helps diabetes and weight loss – New Atlas

December 11th, 2019 10:46 am

An interesting new clinical study is suggesting restricting food intake to a 10-hour window each day may be a simple yet beneficial way to help treat metabolic syndromes such as diabetes or heart disease. The 12-week pilot study revealed the eating intervention, in conjunction with prescribed medicines, improved patients health outcomes.

One of the more fascinating dietary fashions to arise in recent times is known as time-restricted eating (TRE). Instead of interspersing whole days of fasting across a week or month, this eating strategy looks to limit your caloric intake to short windows of time in a given 24-hour period. Generally, TRE methods suggest only eating between four and eight hours a day, meaning a fasting stretch of 16 to 20 hours.

One of the theories underpinning these dietary strategies is that restricting eating to a limited time window better synchronizes a persons caloric intake with their circadian rhythms. Epidemiological studies have found a majority of people spread their food intake over at least 15 hours a day. As little as 10 percent of people compress all their meals into a 12-hour-or-less stretch each day. While some research is building to suggest health benefits to only eating in four- to eight-hour windows, this new study set out to ascertain whether a 10-hour eating window could be just as beneficial.

"There has been a lot of discussion about intermittent fasting and what time window people should eat within to get the benefits of this kind of diet," explains Satchidananda Panda, co-corresponding author on the new study. "Based on what we've observed in mice, a 10-hour time window seems to convey these benefits. At the same time, it's not so restrictive that people can't follow it long-term."

To test the eating strategy on human subjects a team of researchers from the Salk Institute and the University of California, San Diego, conducted a small pilot study. They recruited 19 subjects, most classified as obese and receiving pharmacological treatment for a diagnosed metabolic condition. All subjects self-reported prior eating patterns spanning at least 14 hours a day.

The intervention tested was incredibly simple. Subjects were directed to continue regular diets and exercise but simply compress any caloric intake to a 10-hour window each day, essentially letting their bodies fast for 14 hours across every 24-hour cycle.

For such a small and simple intervention the results were somewhat impressive, with an average three to four percent reduction in body weight and body mass index seen across the entire cohort after three months. Alongside self-reported improvements to general energy levels and sleep quality, the cohort displayed reductions in cholesterol levels and blood pressure at the end of the 12-week trial.

"We told people that they could choose when they ate their meals, as long as they remained within the 10-hour window," says Panda. "We found that universally, they chose to eat breakfast later, about two hours after waking, and to eat dinner earlier, about three hours before going to bed."

The researchers behind the new study are well-aware of the numerous limitations behind such a small trial. Most notably the trial did not include a control group which makes it difficult to clearly correlate the final result with the studied eating intervention. Duane Mellor, from Aston University, points out the lack of control isnt the only problem with this particular study.

In the case of this study there are lots of limitations, not just the lack of a control group a key one being that the act of recording food intake has been shown in other studies to reduce calorie intake and help with weight loss, says Mellor, who did not work on this new study. Also, although lots of tests were done on the participants, it seems unclear how they justify the conclusion that improvements were seen independent of weight change as there simply was not a big enough number of people to make this assessment.

So, were the beneficial effects seen in this study directly related to the TRE strategy? Or were the health improvements more a reflection of the diet indirectly lowering overall caloric intake and making the cohort more aware of their eating patterns?

Its possible to over speculate that time-restricted eating is a magic bullet to health whereas it may be that its just through calorie restriction, suggests Jenna Macciochi, an immunologist from the University of Sussex. On the flip side, for people who are struggling with fad diets it may be a useful tool and help compliance.

Macciochi, who did not work on this new research, does point out the most encouraging part of the new study is that it highlights how easy this particular dietary modification can be implemented and sustained. The compliance rate for the trial was very high, with a significant number of the participants reporting continuing the dietary strategy, in some form, for up to a year. This suggests, unlike some other intermittent fasting or TRE diets, a 10-hour daily eating window is relatively easy to integrate into a persons life, and can be maintained for extended periods of time without too much trouble.

So, moving forward the next step for the researchers is to better verify the metabolic benefits of this eating plan in larger cohorts. A clinical trial is already underway in a much larger group with the hopes of understanding the physiological effects of what could essentially be called a 14:10 eating plan.

The new study was published in the journal Cell Metabolism.

Sources: Salk Institute, Cell Press

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How worms revealed a key protein in insulin synthesis and diabetes – FierceBiotech

December 11th, 2019 10:46 am

By studying the nematode Caenorhabditis elegans, scientists from Vanderbilt University and the University of Michigan have identified a protein that's key for insulin synthesis, the understanding of which they say could lead to new approaches to prevent and treat Type 2 diabetes.

The protein, called TRAP-alpha, is widely shared across worms, flies and mammals, including humans. In a study published in the journal Science Advances, the team showed that TRAP-alpha is required for insulin production, corroborating previous knowledge that alterations in the TRAP-alpha gene are linked to the development of diabetes.

The researchers made the discovery while screening for genetic clues to the PI3K/Akt signaling pathway that may contribute to reduced insulin signaling. Irregularities in the PI3K/Akt pathway have been linked to many human diseases, including cancer, cardiovascular disease anddiabetes.

How ICON, Lotus, and Bioforum are Improving Study Efficiency with a Modern EDC

CROs are often at the forefront of adopting new technologies to make clinical trials more efficient. Hear how ICON, Lotus Clinical Research, and Bioforum are speeding database builds and automating reporting tasks for data management.

The screens turned up TRAP-alpha. The protein is part of a complex known as translocon that helps moveor translocatenewly synthesized proteins into the endoplasmic reticulum (ER) of cells for further processing before theyre eventually secreted.

The researchers discovered that deletingthe C. elegans equivalent of TRAP-alpha affects the worms' insulin signaling pathway.

They went on to delete TRAP-alpha in insulin-making pancreatic beta cells of rats. Doing so led to a sharp decline in total insulin, the team found. Preproinsulin, the precursor molecule to insulin, was not properly transferred into the ER for final processing, so most of it was degraded.

TRAP-alpha was not on anyone's radar in terms of being required for insulin biogenesis, Patrick Hu, the studys senior author, said in a statement. Our work highlights the value of using a model organism likeC. elegansto do an unbiased genetic screen. It led us to a molecule that seems to be important in making insulin and that could very well shed light on the pathogenesis of diabetes, a common disease that affects about 10% of the U.S. population.

RELATED:Subtle chemical shift reverses prediabetes in Merck-partnered mouse trial

Given the prevalence of diabetes, several research groups are also working on new ways to tackle it. Scientists from the University of Utah, in collaboration with Merck Research Laboratories, recently prevented or reversed prediabetes in mice. They did it by shutting down an enzyme called DES1 to reduce the amount of fatty lipid ceramides, which is key in metabolic health.

A team at the University of Geneva treated Type 1 diabetes in mice byconverting non-insulin-producing alpha and gamma endocrine cells into beta cells with the help of two transcription factors, PDX1 and MafA.

Understanding TRAP-alpha could inspire new ideas to prevent or treat Type 2 diabetesand maybe even more diseases, Hu and colleagues argued.

In the current study, the researchers noticed TRAP-alpha plays a role in promoting ER homeostasis, or the balance between incoming proteins and ER the proteins that help fold them. Loss of TRAP-alpha may cause ER stress, which can lead to cell death, the team reported.

Preproinsulin is the first client protein for TRAP-alpha to deliver into the ER for processing, and the scientists hope to find more like it.

It's likely other secreted molecules besides insulin might be affected by TRAP-alpha deletion, Hu said in a statement. If we can understand the broader role that TRAP-alpha is playing in maintaining protein homeostasis, we might develop new ways to approach other diseases, too.

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Harvey Weinstein’s diabetes and spine condition to blame for his appearance – Page Six

December 11th, 2019 10:46 am

Harvey Weinstein hobbled into Manhattan court Friday looking pallid and unsteady thanks to severe diabetes and a spine condition, sources told The Post.

The 67-year-old accused rapist and former powerhouse Hollywood producer who was in court for a new bail hearing has suffered from Type 2 diabetes, back issues and other health problems that have been in free-fall since his arrest, sources said.

Weinsteins health problems paved the way for him to be allowed to wear a modified monitoring device while hes out on bail awaiting trial on sex charges and the gadget was at the heart of Fridays hearing.

Weinstein who had a handler help prop him up as he entered the courtroom was originally outfitted with a regular ankle bracelet, but because of his health issues, bail bondsman Ira Judelson swapped it out for a two-part device. The new device includes a slimmer ankle bracelet with a separate signaling component. The original device is not prone to the same user error.

The one-piece device was problematic for his leg and medical issues, Weinsteins lawyer, Donna Rotunno, told the court of the original, much bulkier monitor.

But Assistant DA Joan Illuzzi-Orbon said Weinsteins ankle monitor was untraceable on at least 56 separate occasions, in violation of his bail conditions. Prosecutors said Weinstein repeatedly failed to keep within range as required.

Due to the violations and new bail reform laws taking effect next year, Weinsteins bail package has to be re-examined, with both sides making their arguments Friday. Justice James Burke is set to rule on the issue Wednesday.

Weinstein is currently free on $1 million cash bail. He faces up to life in prison on charges of predatory sexual assault, criminal sex act and rape in connection with three accusers.

Matthew McDermott

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Diabetes treatment to cost less on cheaper version – Times of India

December 11th, 2019 10:46 am

MUMBAI: There is some good news for the over 72 million diabetics in India, with a cheaper version of a blockbuster drug hitting the market on December 10. The domestic pharmaceutical market is abuzz with news of over 15-20 companies launching generic versions of the widely-prescribed anti-diabetic drug Vildagliptin, with its price expected to crash by half.

The potential of more affordable diabetic care comes in the wake of Swiss major Novartis-owned Vildagliptin losing patent on Monday a development closely watched for months. Dozens of companies have readied plans to get a slice of the action in the growing Rs 14,000-crore diabetes therapy market, with the number of players expected to cross 50 soon.

With the drugs patent expiry, the price may drop to Rs 6 per tablet over the next few months, from the existing Rs 20-25 each. What makes the patent expiry significant for Indian pharma is that Vildagliptin is the first among the gliptins, a relatively new class of oral diabetes drugs, to get off the block, and also the first diabetes medicine whose end of patent life is being seen by industry. Vildagliptin is a part of a class of diabetes medications called dipeptidyl peptidase IV or DPP4 inhibitors.

The innovator brand Galvus (along with combination of Metformin) cornered around Rs 600 crore, a lions share of total Vildagliptin market of Rs 950 crore (moving annual total (MAT) November 2019). The company also has agreements with USV, Cipla and Abbott, with their brands Jalra, Vysov and Zomelis respectively available in 50mg Vildagliptin, and in combination with Metformin.

Days before the launch, the market started hotting up with Mumbai-based Eris Lifesciences acquiring Zomelis from Novartis for around Rs 100 crore, and USV reportedly being in talks to acquire Jalra. When contacted, a Novartis spokesperson said, When patents expire, high-quality generics help lower the overall cost of healthcare and improve access to medicines for societies around the world, in a circle of discovery, development, commercialisation and loss of market exclusivity. We will continue to serve people living with diabetes through the innovator molecule in India, Galvus.

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Message to young women with diabetes: Marriage and children, you can have it all! – Times of India

December 11th, 2019 10:46 am

In the last 21 years, I have been working closely with young women who have type 1 or type 2 diabetes and many of them have voiced a persistent concern and fear: will they be able to lead a fulfilling life as wives and mothers. They seem to have received little or no reassurance from family and friends. Social discrimination, misconceptions and stigma are still creating psychological and emotional problems for these young women.Research shows that societal stigma, shaming or discrimination of people with diabetes has a negative impact on patient self-care and leads to poor treatment outcomes.[i] Women face much more of this than men. They are deemed unfit for marriage and motherhood. They face this stigma on all fronts: from their own family, extended relatives, colleagues at work and from prospective spouses and their families.I would like to clear some of these misconceptions and send out a message of hope and reassurance to these young women.Never assume, always ask the doctorLack of understanding is the source of this stigma, both in rural and urban India. Poor understanding of the disease at all levels - patients, families, prospective in-laws, co-workers - creates a web of fear about the disease, its risks and its impact on everyday living. So many families assume no one wants to wed their daughter, because she has a lifelong chronic condition. They also assume that the young woman will be unable to bear children, and if she does, the child will be at risk of developing diabetes at some point in life.

In light of this, it becomes the doctors responsibility to guide patients and their families, give them the information they need on general diabetes management and particularly on pre and post-natal diabetes care. Patients need to be told that while diabetes does increase the risk of certain complications, advancements in medicine and technology have made these well manageable today.

Do not hide your condition, and never neglect your medicationI have met several young women patients in the process of finding a marriage partner, struggling with the dilemma of whether to tell their prospective partners and families about their diabetes status. Many have reported that when they did open up about their condition soon after marriage, they were advised to seek alternative medical treatment by their husbands and in-laws and asked to give up insulin therapy! Hiding the fact that they have diabetes has also led to an erratic medication schedule leading to horrifying results. Many patients developed a condition called ketoacidosis (excess blood acids called ketones) and needed to be rushed to the emergency room.

One of my biggest concerns is that newly diagnosed patients sometimes keep their diabetes status a secret from even their immediate family and colleagues for fear of judgement. Some of my new patients admit to taking their insulin or checking their blood sugar only in the privacy of their washroom, and do not do so as often as recommended if they are in a public place.

My message to patients here is simple: no person and no circumstance must ever trump your own health. Neglecting to monitor your blood sugar or to take your medication as prescribed, can put you at high risk of many complications, some of which are life threatening. Patients on insulin therapy should ask their doctor to help pick an insulin type that suits their daily schedule and body requirements.

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She invented a product to help those with Type 1 diabetes, and she’s featured in a new book – East Idaho News

December 11th, 2019 10:46 am

Laurel Bloomfield of Rigby is a contributing author for a new book targeted to entrepreneurs. | Courtesy photos

RIGBY Laurel Bloomfield of Rigby is an entrepreneur, inventor, mother and wife, and she will soon add author to her list of accomplishments.

She is one of 71 authors who will be featured in Air Fryer Secrets. Its not a cookbook rather, its an anthology providing business-building tips and strategies. Each chapter was written by a different author and caters to a specific niche in the marketing and entrepreneurial space.

Everything you would need to start an online business today is covered in the book, Bloomfield tells EastIdahoNews.com.

Bloomfields contribution is a chapter about intellectual property and how a product developer can write their own patent. She co-created a product with Nicholle Peterson and Katie Larsen several years ago designed to help those with Type 1 diabetes who wear an insulin pump. Its a pocket thats placed in the lining of clothing to hide it from view and keep it safe from damage.

RELATED | Local moms design a trendy way to carry insulin pumps

If you send a 5-year-old kid to school with a $10,000 pump, and they try to use the bathroom, it could fall in the toilet. Other kids have cut the tubing thats hanging out of their shirt going from the pump to the infusion site. That can be a life-threatening situation, Bloomfield says.

Her pocket helps keep that device safely up against their body and holds all the tubing in place to avoid all risks of danger. The pocket also gives kids a way to hide their condition so they do not become a spectacle to people around them, she says.

I think thats important for kids dealing with Type 1 diabetes. Sometimes theyre expected to be the spokesperson for this huge disease just because they have this noticeable thing (on their body). The pocket allows them to just be kids, says Bloomfield.

Bloomfields pocket concept gained a lot of traction from some of the leading insulin pump manufacturers in the world. It was put on the market about three years ago once her fully-issued patent was approved. Today, its sold online and in stores under the name Pocket Innerware.

Boise resident Kevin Quinn, the lead author of Air Fryer Secrets, has worked with Bloomfield on numerous development projects. Hes a software developer and a partner at a CBD company, among other things. He invited her to share her expertise with readers for this book.

The inspiration for the book came from a series of live Facebook videos Quinn began posting about eight months ago.

I wanted to show folks what I could cook in the air fryer one Friday. It was funny. People tuned in and had some fun with it. Then it started to grow and people started to ask What are you cooking for Fryer Friday?' Quinn says.

The initial post was intended as a joke, but it quickly went viral and eventually became a weekly bit called Fryer Friday.

The videos have since become a Facebook engagement tool to help build an audience for many of his business projects. The title of the book is a play on words intended to convey its central message of putting yourself out there to build brand awareness.

You need to decide who your audience is that you want to sell to, and then find a unique way to sell to them, Quinn says. This book will give them so many ideas (on) how to do that.

Bloomfield and Quinn recently launched a business together called Launch Incubator, which helps entrepreneurs find an audience for their product.

Bloomfield says she is excited to be able to offer marketing strategies and other resources for current and prospective business owners.

Its kind of like a digital marketing Bible. Its something that, when I got into this space 18 months ago, I wish I wouldve known more about, Quinn says.

Air Fryer Secrets will be available to buy through Amazon on Dec. 19. Visit the website to learn more.

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Limited eating times could be a new way to fight obesity and diabetes – The Conversation US

December 11th, 2019 10:46 am

People with obesity, high blood sugar, high blood pressure or high cholesterol are often advised to eat less and move more, but our new research suggests there is now another simple tool to fight off these diseases: restricting your eating time to a daily 10-hour window.

Studies done in mice and fruit flies suggest that limiting when animals eat to a daily window of 10 hours can prevent, or even reverse, metabolic diseases that affect millions in the U.S.

We are scientists - a cell biologist and a cardiologist - and are exploring the effects of the timing of nutrition on health. Results from flies and mice led us and others to test the idea of time-restricted eating in healthy people. Studies lasting more than a year showed that TRE was safe among healthy individuals. Next, we tested time-restricted eating in patients with conditions known collectively as metabolic syndrome. We were curious to see if this approach, which had a profound impact on obese and diabetic lab rats, can help millions of patients who suffer from early signs of diabetes, high blood pressure and unhealthy blood cholesterol.

Its not easy to count calories or figure out how much fat, carbohydrates and protein are in every meal. Thats why using TRE provides a new strategy for fighting obesity and metabolic diseases that affect millions of people worldwide. Several studies had suggested that TRE is a lifestyle choice that healthy people can adopt and that can reduce their risk for future metabolic diseases.

However, TRE is rarely tested on people already diagnosed with metabolic diseases. Furthermore, the vast majority of patients with metabolic diseases are often on medication, and it was not clear whether it was safe for these patients to go through daily fasting of more than 12 hours as many experiments require or whether TRE will offer any benefits in addition to those from their medications.

In a unique collaboration between our basic science and clinical science laboratories, we tested whether restricting eating to a 10-hour window improved the health of people with metabolic syndrome who were also taking medications that lower blood pressure and cholesterol to manage their disease.

We recruited patients from UC San Diego clinics who met at least three out of five criteria for metabolic syndrome: obesity, high blood sugar, high blood pressure, high level of bad cholesterol and low level of good cholesterol. The patients used a research app called myCircadianClock, developed in our lab, to log every calorie they consumed for two weeks. This helped us to find patients who were more likely to spread their eating out over the span of 14 hours or more and might benefit from 10-hour TRE.

We monitored their physical activity and sleep using a watch worn on the wrist. As some patients with bad blood glucose control may experience low blood glucose at night, we also placed a continuous glucose monitor on their arm to measure blood glucose every few minutes for two weeks.

Nineteen patients qualified for the study. Most of them had already tried standard lifestyle interventions of reducing calories and doing more physical activity. As part of this study, the only change they had to follow was to self-select a window of 10 hours that best suited their work-family life to eat and drink all of their calories, say from 9 a.m. to 7 p.m. Drinking water and taking medications outside this window were allowed. For the next 12 weeks they used the myCircadianClock app, and for the last two weeks of the study they also had the continuous glucose monitor and activity monitor.

After 12 weeks, the volunteers returned to the clinic for a thorough medical examination and blood tests. We compared their final results with those from their initial visit. The results, which we published in Cell Metabolism, were pleasantly surprising. We found most of them lost a modest amount of body weight, particularly fat from their abdominal region. Those who had high blood glucose levels when fasting also reduced these blood sugar levels. Similarly, most patients further reduced their blood pressure and LDL cholesterol. All of these benefits happened without any change in physical activity.

Reducing the time window of eating also had several inadvertent benefits. On average, patients reduced their daily caloric intake by a modest 8%. However, statistical analyses did not find strong association between calorie reduction and health improvement. Similar benefits of TRE on blood pressure and blood glucose control were also found among healthy adults who did not change caloric intake.

Nearly two-thirds of patients also reported restful sleep at night and less hunger at bedtime similar to what was reported in other TRE studies on relatively healthier cohorts. While restricting all eating to just a six-hour window was hard for participants and caused several adverse effects, patients reported they could easily adapt to eating within a 10-hour span. Although it was not necessary after completion of the study, nearly 70% of our patients continued with the TRE for at least a year. As their health improved, many of them reported having reduced their medication or stopped some medication.

Despite the success of this study, time-restricted eating is not currently a standard recommendation from doctors to their patients who have metabolic syndrome. This study was a small feasibility study; more rigorous randomized control trials and multiple location trials are necessary next steps. Toward that goal, we have started a larger study on metabolic syndrome patients.

Although we did not see any of our patients go through dangerously low levels of glucose during overnight fasting, it is important that time-restricted eating be practiced under medical supervision. As TRE can improve metabolic regulation, it is also necessary that a physician pays close attention to the health of the patient and adjusts medications accordingly.

We are cautiously hopeful that time-restricted eating can be a simple, yet powerful approach to treating people with metabolic diseases.

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Homepage Round-Up: Depressed Doctors Make More Medical Errors; The Lasting Effects of Gunshot Wounds; and More – DocWire News

December 11th, 2019 10:44 am

Here are the top stories covered byDocWire Newsthis week in the Homepage section. In this weeks edition of the round-up: physicians suffering with symptoms of depression make more medical errors, mining alcohol related Tweets is the best way to gather public health data; short-term exposure to air pollution increases hospital admissions and costs; and gunshot wound survivors have high rates of PTSD, unemployment, and substance abuse.

Physicians suffering from symptoms of depression are more likely to make medical errors, according to the findings of arecent studypublished inJAMA Network Open. By combining data from multiple studies, this systematic review and meta-analysis found that physician depressive symptoms were associated with increased risk for perceived medical errors and that the association between depressive symptoms and perceived errors was bidirectional, the authors wrote.

A new study published in theAmerican Journal of Preventative Medicinesuggests that mining peoples alcohol-related tweets and online searchers is a faster, and more efficient method than the tradition method of collecting rigorous public health data through large survey-based studies. Informal social media and search data may be really important for detecting and responding to things that we dont anticipate or that occur naturally, said the senior study author: Our results give confidence in our public health tools and in using novel data approaches to measure health behaviors and policy effects a real win.

Short-term exposure to fine particulate matter with diameter less than 2.5 m (PM2.5)is associated with increased rates of hospital admissions and health insurance costs, according to the findings of arecent studypublished inBMJ. New causes and previously identified causes of hospital admission associated with short term exposure to PM2.5were found, the researchers wrote. These associations remained even at a daily PM2.5concentration below the WHO 24-hour guideline. Substantial economic costs were linked to a small increase in short term PM2.5.

The lasting effects of gunshot wounds (GSWs) reach far beyond mortality and economic burden, and survivors incur higher instances of post-traumatic stress disorder (PTSD), unemployment, and substance abuse, according to thefindingsof a new study published byJAMA Surgery. The researchers wrote that: Survivors of GSWs may have negative outcomes for years after injury. These findings suggest that early identification and initiation of long-term longitudinal care is paramount.

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Helsinki’s Neosmart Health raises 1.2 million to expand its patented preventative healthcare system – Tech.eu

December 11th, 2019 10:44 am

Neosmart Health, the Finnish preventative healthcare startup, has closed a 1.2 million seed round to pursue its mission of keeping people healthy. The round was led by various investors from the Nordics, North America, and Africa, including Sami Laine, Martti Lepist, Kari Helin, Ahmed Eltigani, Niilo Pellonmaa, and Timo Mkel.Over 75% of chronic illnesses burden arise from preventable conditions and only with preventive healthcare, we can manage the costs and extend the healthy lifetime for all of us, said co-founder and CEO Marko Nurmela.The company combines technology, such as AI and wearables, with traditional medicine to design individualised health optimisation plans for patients.Our methodology is based on deep data analytics and what differentiates us from others is our holistic approach towards health. We look at health from multiple fronts, including comprehensive blood analysis, gut microbiome, food sensitivity, immunity profile, wearables data, genomics and everything else that is required for an individual, explained founder and Chief Medical Officer, Dr. Pertti Lhteenmki.In addition to data-driven tools, patients are paired with Neosmart-licensed doctors at Neosmarts brick-and-mortar clinics. Part of the companys short-term vision is to attract and license more doctors in the Neosmart system.Since starting its operations in 2018, the company has hired 19 employees, located in the Helsinki headquarters or the Dubai office. Both locations have afforded strategic partnerships: the retailer S-Group in Finland, and the Dubai Sports Council and Dubai government (though no further information has been disclosed on this point). So far Neosmart also two patents in the US and other markets.Commenting on the companys aspirations, Marko said: This is just the beginning and were already in discussions for our Series A round next, to accelerate the development of our deep data analytics platform and AI, and start offering our services in new markets Sweden, Estonia, Dubai and start the ground work on our expansion to the US, UK, India, China and Japan.

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Is it wrong to think of food as medicine? – The Irish Times

December 11th, 2019 10:44 am

We need our clinicians to buy in to the concept that thy food is thy medicine, and thy medicine is thy food. Instead of arguing over what Hippocrates meant by this, exactly or whether he even said it why not encourage his medical descendants to take up this mantle?

Arguably, most doctors are more equipped to write a prescription or make a referral than to discuss nutrition and lifestyle interventions. Without question, pharmaceuticals have their place, but so does food as medicine, and our brilliant doctors in whom we trust must take greater steps towards preventative care and lifestyle interventions that will address the growing burden of type 2 diabetes, obesity and malnutrition in this country.

An estimated 60 per cent of adults and one in four children in Ireland are either overweight or obese. The direct and indirect costs to the exchequer which are associated with obesity are estimated to exceed 1 billion per annum.

The Healthy Ireland Framework 2013-2025 states that the health and wellbeing of everyone living in Ireland . . . is the most valuable asset that we possess as a nation. The report goes further to say that health in Ireland will be unsustainable in the future due to lifestyle diseases and ageing populations. It makes a strong argument for greater emphasis on illness prevention.

Therefore, I ask our politicians, the HSE and the Department of Health: if our health and wellbeing is such a prized asset, why isnt more being done to protect it?

Both hospitals and the food service sector are considered key areas for public policy interventions in this regard. Yet many doctors have no nutrition training. In the US, this has resulted in changes to curriculums whereby culinary medicine is being incorporated into doctor training in Harvard and Tulane universities, and even in some US hospitals. Nutrition knowledge and cookery education, like prescribed exercise, should become another tool in a clinicians toolkit. Ironically, the one place that we go to to get help when chronically unwell is a hospital. Yet doctors working there are ill-equipped to intervene or even get involved in this critical area.

In the UK, 50 million has been spent on failed bids to improve hospital food. Reports suggest 17 separate government initiatives since 2000 have resulted in no discernible improvement in the quality of meals served to patients. Albert Roux, James Martin and Loyd Grossman have all tried. Prue Leith has now taken up the baton.

But remaking hospital menus isnt easy.

Hospitals have to operate on strict budgets and food supply is frequently outsourced to companies that specialise in high volumes of food at a low cost often resulting in packaged and processed foods. Research shows us that 30-40 per cent of hospitalised patients are considered to be at risk of malnutrition. However, hospitals are a place where nutritionism rules.

Nutritionism is a term coined by the Australian sociologist Gyorgy Scrinis, and popularised by food writer Michael Pollan. It means reducing the value of a food to specific nutrients it contains. Its a little like the food pyramid which forms the basis of diet recommendations in Ireland.

A cereal advertisement I viewed recently is a perfect illustration of how nutritionism works. It talks about superfoods (health halo, anyone?) and we KNOW superfoods are healthy, right? By eating these cereal products, we get more zinc, more fibre and folic acid than . . . what? Not eating these processed cereals?

So how do we get zinc, iron, vitamin C, B6, fibre and folic acid if we dont eat the cereal?

Well, for starters we could eat meat, shellfish, legumes, nuts, dairy and eggs and even some dark chocolate for the zinc and iron. But the ad implies that eating more chocolatey cereal will serve you better than half a cup of black beans. As Marion Nestle, professor of nutrition at NYU, points out, such ads are not saying whether the iron from the fortified cereal is going to be absorbed as well as from the black beans, or what additional benefits youll get from eating the black beans and how much sugar is in the cereal versus the black beans. (For the record, 78 per cent of the cereal will turn to glucose once you eat it).

What we eat is central to human health, enabling the cells in our bodies to perform their functions via the nutrients, vitamins and energy consumed, but food also goes beyond calories and macronutrients. Anthropologists often declare You are what you eat, and certainly, by examining a persons diet, much can be gleaned about their background, financial status, religious beliefs and education level.

Since the 1970s, nutrition and public health experts have translated reductive principles Eat less fat! Eat less salt! Avoid processed foods! into dietary guidelines for the general public, telling us what to eat more of (fibre, vitamins, calcium, iron, Omega 3s, for example) and to avoid foods considered bad for health, such as saturated fats and refined foods high in sugar, salt and fat. Arguably, this abstract dietary advice is an oversimplification of something much more nuanced and complex. There are so many reasons as to why we eat the food that we do: for pleasure, convenience, and the cost of food, or due to food knowledge and our culture. Therefore, thinking about food in terms of calories-in and calories-out is reductive a mechanical approach [that] plays right into the hands of the food industry, as food writer Joanna Blythman says in her book What to Eat.

Food in hospitals is a budgetary nuisance. Improving the quality of hospital food service is complicated it has to deal with procurement, production, distribution/service, and safety/sanitation all of which are interrelated. Therefore, quality improvement strategies should be developed from a holistic point of view with engineering expertise: food service professionals in hospitals need to continuously research, plan and manage production processes to improve quality of products and efficiency of processes.

More chefs must be trained in culinary nutrition (thankfully happening out in IT Tallaght) and empowered as valued team members in hospital food service quality management who can communicate with patients.

If we could radically improve the food environment within hospitals, what impact would that have on both staff and patients?

Hospital food is often hardly recognisable as nourishing food, but rather as a source of safe calories. Food safety dominates our food production and is prioritised at all costs often at the expense of pleasure, culture and consumption. In addition, patients face a myriad of problems: inappropriate eating positions, food left out of reach, sounds, smells and cold temperatures that negatively affect food intake. Research shows that energy intake is improved among patients eating at a table rather than in bed ideally patients should eat communally unless they are completely bed-ridden, which would inevitably help with access, palatability and food waste. All of these principles should form part of a culinary medicine philosophy.

We should take the ounce of prevention approach. I think we can all agree that the rising cost of healthcare is unsustainable and that the economic burden of diet-related noncommunicable health risks and diseases is growing. Yet, while there is an obvious lack of healthy food procurement and promotion policies in institutions, worksites, schools and Government, it seems blindingly obvious to many of us that prevention is better than cure. For manypatients, nutritious food is medicine.

But what about detractors who say food is not medicine? That it doesnt matter if you get the iron and folate from cereals or whole foods whats important is just to get the nutrients. And this is where the arguments start to fall down: we know that iron is a mineral that serves several important functions such as carrying oxygen throughout your body and making red blood cells. However, although synthetic nutrients are almost chemically identical to those found in whole foods, the production process is very different to the ones found naturally in plants and animals. So despite the similar structures, your body may react differently to synthetic nutrients, especially when it comes to absorption.

When you eat whole foods, youre not consuming single synthetic nutrients, but rather a whole range of vitamins, minerals and enzymes that work synergistically to improve absorption: synthetic nutrients are unlikely to be used by the body in the same way. Take vitamin E, for example: studies show that natural vitamin E is absorbed twice as efficiently as synthetic vitamin E.

If clinicians better understood food and its importance to health and wellbeing, and made that understanding available to patients, families and healthcare systems for high-impact, low-cost, high-value care, then what effect would that have on the health of our nation?

And before you think I am suggesting that chewing parsley could replace a surgery, consider the following: is it wrong to think of food as medicine? Does it do a disservice to both food and medicine? Possibly because in reality, food is so much more than medicine: its social, its cultural and its a huge part of our lives. It is not just fuel and it is much more than nutrients but overemphasising the immediate impact of eating a superfood whilst ignoring long-term eating habits misses the mark. Eating junk food occasionally is very different to the impact on health when repeated regularly and combined with other unhealthy lifestyle habits (lack of sleep, insufficient exercise, smoking, drinking, stress).

Food is a significant human exposure and those of us fortunate enough to have food to eat every day can use it to impact our general health and wellness, including the prevention (or promotion) of chronic illness, and the management of virtually all diseases.

Food can definitely be medicine.

Too frequently though, the power of healthful eating is underrecognised or underapplied. Guidance related to food is not often part of a physicians armamentarium. This needs to change.

We need food education for our children and the best food environments for our hospitals.

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Being Queer in the Jungle: The Unique Challenges of LGBTQ Scientists Working in the Field – The Good Men Project

December 11th, 2019 10:44 am

The Stonewall Riots occurred on June 28, 1969. It was this summer evening that sparked the Gay Rights Movement. Now, forty-eight years later, the world celebrates Pride Month every June to celebrate, honor, support, and fight for the lesbian, gay, bisexual, transgender and queer (LGBTQ) community.

The queer community is resilient. No matter what obstacles they encounter, their battle to live, pursue their passions, and contribute to society endures. For many queer people that passion is science. Queer scientists such as Alan Turing who was crucial in ending World War II, and Sara Josephine Baker who made unprecedented breakthroughs in child hygiene and preventative medicine.

Stonewall Inn, site of the 1969 Stonewall riots, New York City, USA

This blog post is meant to bring attention to queer scientists that are working in the field. Field research encompasses any type of scientific research that involves collecting data in non-laboratory locations. Several scientific areas involve fieldwork such as zoology, paleontology, and botany. The field is a fun and exciting place to perform science, however, for those who identify as queer1, working in the field can present challenges that may not be known to cis-gendered1or straight scientists.

The biggest decision for all LGBTQ individuals is whether to disclose their sexuality or gender identity. The decision to be out of the closet is an incredibly complex one in which all queer individuals have to evaluate the benefits versus costs. In general, staying in the closet and not disclosing ones sexuality or gender identity can be incredibly caustic, but there are many situations where staying in the closet is potentially safer than being out.

The risks for being out in the field are very location dependent. Dr. Siobhn Cooke from Johns Hopkins School of Medicine currently does work in theDominican Republic and Colombia. She feels comfortable being out and talking about her wife while in the Dominican Republic and Columbia. However, when she did field work in Tanzania she did not come out because she thought it would be unsafe. African and Middle Eastern countries can be particularly dangerous for queer scientists. Homosexuality is punishable by death in Sudan, northern Nigeria, Somalia, and Saudi Arabia, and is illegal in a slew of other countries including Ethiopia, India, Tanzania and Uganda. These types of legal restrictions obviously make it unsafe for a queer scientist to be out.

Global Laws Against Homosexuality

Even if being LGBTQ is not illegal, local views and customs can make it unsafe or difficult for queer scientists to be out. Close relationships with locals are required for scientists to obtain permission to perform their research in a specific location or to garner an opportunity to employ locals to aid in data collection. Local stigma against queer people and the discovery that a queer scientist is in a research group can result in locals refusal to help the scientists.

Local stigma against queer people and the discovery that a queer scientist is in a research group can result in locals refusal to help the scientists.

Lewis Bartlett, a graduate student who studies bees in the United States South, has experienced these types of challenges. His research includes collaborations with rural beekeepers many of whom hold conservative views on LGBTQ individuals: Parts of the fieldwork often involve extended social situations with collaborators, local practitioners etc. In these informal settings with food, drink, and an expectation to be charming and sociable it is absolutely a worry that you may say something which jeopardizes a rapport with a collaborator. Much of this kind of research working with small hold beekeepers is done on a very informal basis and requires maintaining strong personal connections with these people. It is absolutely distracting to have to police what directions conversations go in.

Dr. Christopher Schmitt of Boston University exploresmechanistic and adaptive aspects of developmental variation. While doing fieldwork in South Africa, it was relatively safe for Dr. Schmitt to be out. However, the potential for being out of the closet did not necessarily mean it was the best idea in terms of successfully carrying out his science. There was one experience where two of his local field workers were using homophobic epithets. Dr. Schmitt knew that it would be risky to express his disapproval or discomfort. Speaking up could have led the field workers to suspect he was gay thereby putting a strain on the working relationship and potentially impeding his research. Luckily in this situation, one of Dr. Schmitts colleagues to whom he was out did speak up to express their discomfort with how the field workers were talking.

Knowing that there are situations where it would be safer for queer scientists to stay in the closet while working in the field, a discussion on the deleterious consequences of staying in the closet is critical. Dr. John Pachankis from the Yale School of Public Health studies the psychological implications of staying in the closet. Through his research he has come up with acognitive-affective-behavioral model of the consequences of staying in the closet. In this model Dr. Pachankis discusses the intersection between cognitive energy, affect, and behavior and its relationship to queer individuals remaining in the closet. Cognitive energy encompasses the amount of mental energy spent on psychological processes such as attention, reasoning, and decision making. Affect, meanwhile, describes emotional states such as joy, guilt, and depression.

In Dr. Pachankis description of his cognitive-affective-behavioral model, he explains how closeted individuals spend a significant amount of cognitive energy engaging in preoccupation and vigilance to make sure that others do not suspect they are queer. These cognitive activities of preoccupation and vigilance can result in affective responses of guilt, shame, demoralization and depression. These affective states, then have behavioral repercussions including avoiding social situations, weakening of close relationships, and engaging in risky behaviors such as unprotected sex and drug abuse.

While I never went back in the closet (something Im not sure I would know how to do anymore) it did undermine how authentically I felt I bonded with collaborators and colleagues. Dr. Schmitt

Staying in the closet, therefore, puts unnecessary cognitive demands for a queer person in the field where their main goal is to be a good scientist and collect data. When Dr. Schmitt was doing research in Gambia he ended up leaving a month early. A large part of this was due to the strong anti-gay feelings in the country where the president of Gambia was putting stings on gay people and making comments about slitting the throats of gay people.

When going to field sites in conservative areas of the American South, Lewis Bartlett said Being unaccustomed to editing how I present makes consciously considering it always a shock (this fieldwork is an annual event) modifying how I dress or act in order to not cause unnecessary problems will always feel upsetting. While I never went back in the closet (something Im not sure I would know how to do anymore) it did undermine how authentically I felt I bonded with collaborators and colleagues.

During an 18 month stint in Ecuador Dr. Schmitt described his experience of staying in closet. I wasnt ashamed of being gay, per se, but the same triggers that caused those feelings were there: having to hide, having to self-censor, playing the pronoun game, thinking twice before every statement, guarding your vocal inflections and hand gestures, choosing the correct interests to allay suspicions, making noncommittal comments about women when the other men ask for/expect them, getting crushes on men that you cant think too much about or reveal or talk to anyone about or act on because it would cause problems its all there again, and its all very hard to shake those feelings, even after years of living authentically and having grown into confidence as a gay adult.

Being transgendered in almost anywhere in the world is incredibly difficult, and this is of course true for transgender scientists working in the field, which presents its own unique challenges. Situations can be tricky for transgender scientists depending on where they are in their transitioning process. One challenge is documentation and paperwork. It can obviously be very problematic if the gender identification on all documentation is not the same. However, there can be even trickier situations.

One transgender scientist who had already been at a field site in East Africa prior to their physical transition knew that they were going to return to the field site. They made the very difficult decision of postponing their transition process. I consider my decision to delay my physical transition in order to conduct fieldwork an incredible sacrifice. I would have to delay the start of my life for another year. This postponement, however, was not sustainable, and they decided to start on a low dose of hormone replacement therapy. Although this decision was positive it was not without its challenges. For me, this decision was life-saving and I am finally getting better and am able to enjoy my research as I did before. But its not an ideal situation. As I am becoming my authentic self, I have to carefully monitor how others are perceiving me. Has my voice dropped too much? Is my facial structure noticeable different?

Margaret Mead was an anthropologist who studied indigenous people of the South Pacific and Southeast Asia. She had a romantic relationship with fellow anthropologist Rhoda Metraux and they lived together from 1955 till Meads death in 1978.

Discussing safety in relation to scientific research is standard. When going into the field, scientists are given a heads up on safety issues related to diseases and wildlife. They get vaccines, take anti-malarials, and take precautions on what water to drink. The amount of effort principle investigators put into preparing their students and field workers can vary. For some it is limited to basic preparation of what is expected of them in the field while others will determine if their students and field workers will be able to handle the psychological stressors of being in the field.

It could be beneficial for everyone if there was a standardized method to prepare individuals going into the field. In addition to principle investigators addressing disease risks and physical dangers, it would be valuable to talk about other potential safety issues such as cultural views related to queer people or women since dangers and safety issues are greater for these populations. By having these discussions standardized, it would mean that this information would be disseminated to scientists of all genders and sexualities. A standardized script would mean that principle investigator wouldnt have to be worried about making assumptions of whether a prospective student or research assistant were queer. Furthermore, it is important for men, cis-gendered, and straight scientists to know the kinds of risks that their female and queer colleagues may encounter.

For Dr. Cooke who is in her first year being a principle investigator at an institution with graduate students, she plans on having these conversations since carefully considered conversations about identity have generally not been on the table. Furthermore, being out is especially important for Dr. Cooke so that students know it is possible to be a queer woman scientist.

1Terminology:Queer:an accepted umbrella term to describe individuals who are neither cis-gendered nor straight Cis-gendered: individuals whose gender identity matches with their biological sex

Disclaimer: All interviewees provided permission to use their names and quotes.

This post was previously published on SpringerOpenBlog and is republished here under a Commercial Commons license.

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Read more:
Being Queer in the Jungle: The Unique Challenges of LGBTQ Scientists Working in the Field - The Good Men Project

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