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Healthy Ageing APAC Summit 2020: Academic and industry experts from Singapore, India, Thailand and Malaysia join the bill – FoodNavigator-Asia.com

January 21st, 2020 8:43 am

The event, which this year returns to Singapores Hilton hotel from July 7-9, will feature speakers from the Indian Institute of Integrative Medicine, National University of Singapore and Mahidol University / The Food Science and Technology Association of Thailand (FoSTAT),

There will also be sessions revealing the latest insights from the Malaysian Dietary Supplements Association (MADSA), Food Industry Asia and Mercer.

Delegate registration is now open, with an earlybird 20% discount offer.

The event takes place as the number of older persons in the region is expected to more than double from 600 million today to nearly 1.3 billion by 2050.

Organised by the publishers of FoodNavigator-Asia.com and NutraIngredients-Asia.com, the event brings together brands, suppliers, regulators and market experts to assess how the industry can meet the food and nutrition needs of older consumers of today and tomorrow.

Editor-in-Chief of both titles, and Regional Head of APAC at publisher William Reed, Gary Scattergood, said:Crucially, the event comes from the perspective that healthy ageing begins from conception. It assesses innovative food and nutrition solutions across all age spans, which will ultimately help people enjoy a healthy, as well as longer, older age.

Confirmed speakers include:

John Hellmann, Vice President, Government Affairs, Asia Pacific, Herbalife

Dr Yong Shan May, Principal Scientist, Bioefficacy and Bioactive Discovery, Brands Suntory

Dr Sam Henderson, Chief Scientific Officer, Cerecin

Dr Lesley Braun, Director, Blackmores Institute

Tana Limpayaraya, CEO, Amado Group (Thailand)

Dr. Mario Chin, Co-founder & CSO, Avant Meats

Associate Prof Satoshi Fukumitsu, Innovation center manager, NIPPN

Assistant Professor Anadi Nitithamyong Mahidol University / FoSTAT

Dr Jung Eun Kim, Assistant Professor, Department of Food Science and Technology, National University of Singapore

Dr. Ram Vishwakarma, Director, Indian Institute of Integrative Medicine Jammu

EE Fern Wong, Board Member, Malaysian Dietary Supplements Association

Godelieve van Dooren, Partner, Mercer

Some of the key themes for the 2020 event will include:

Snacking for seniors:How the worlds leading FMCG brands can create options that aid Healthy Ageing

Reformulation and fortification:Expert insights on how to tackle the ticking economic and social timebomb of obesity and diabetes through reformulation strategies

Innovation for infants:How the latest research and product innovation is helping infants make the best start in life leading to tangible health outcomes in later life

Functional foods focus:The regions leading functional foods pioneers will share their healthy ageing strategies and experience in our dedicated showcase

Protein potential:The latest research around intake levels, product innovation and muscle health.

Indigenous insights:Research is booming in areas such at TCM, Ayurveda and Maori/Aboriginal botanicals and how they can be used for food and nutrition innovation. Well be hearing from an expert panel

Retail revolution:The regions leading retailers will share their views on how they can meet the needs of senior consumers, both online and offline.

Medical and clinical case studies:Well be hearing about the key advances being made in the area of foods for hospital patients as well as clinical nutrition solutions.

Markets and policy:Regulatory experts, decision makers, economists and trends analysts will be sharing the latest date into the economic, social and policy impacts of ageing.

To find out more, and view our highlights video from the 2019 event, please visit theevent website.

If you are from a major finished product brand and would like to discuss speaking opportunities, email gary.scattergood@wrbm.com

And to find out about our comprehensive partnership and sponsorship opportunities, email sueann.peh@wrbm .com and tim.evans@wrbm.com

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#MondayMotivation: This Week, Try To Make These 6 Lifestyle Changes For Better Health And Weight Loss – NDTV News

January 21st, 2020 8:43 am

Try to have your meals at the same time every day, Luke Coutinho suggests

Every Monday comes with an opportunity to work towards improving your health and fitness goals. Taking care of your health, weight is fitness is important because of many reasons. It makes you look and feel good. It is important to keep you disease-free. And more importantly, staying fit and healthy can also make you happy. In one of his recent videos on Facebook, lifestyle coach Luke Coutinho shares 6 tips that can follow this week for better physical, mental and emotional health.

Within the next five days, you need to follow these lifestyle changes every day and it can help in improving your health.

Try to get an early dinner, preferably by sunset. Luke suggests that you should have your dinner by 6.30-7 pm in case sunset happens around that time. Try to keep a gap of 2 hours between your dinner and bed time. Having early dinner is one practice that can help you sleep better, improve your sleep quality, reduce your weight, appetite, cravings to sugar, caffeine and much more.

This week try to eat dinners early, preferably by sunsetPhoto Credit: iStock

For the next 5 days, try to eat your breakfast, lunch, dinner and the other mid meals at the same time. Achieving this goal can control cravings effectively.

Organise your day in a way that you sleep at the same time every day and also wake up at the same time. Starting today, sleep at the same time every day and wake up at the same time. Doing this can reduce the lethargy and fatigue

Aim for exercising regularly this week. Aim for an hour, half hour or even 15 minutes if you can this week. Regular exercise is the most effective way to achieve good health, lose weight and maintain a healthy weight. It can help in getting your heart rate up, regularise your blood pressure, and much more.

Every morning when you wake up, just spend 5 to 10 minutes in doing what you love. It should be something that calms you down and motivates you to go ahead with the day on a positive note. It can either be meditation, or making a to-do list for the day, prayer, music, yoga or anything else that you would like to start your day with.

Have a morning ritual that calms you down and helps you start your day on a refreshing notePhoto Credit: iStock

Restricting use of social media is important for your own mental peace. It can help you get some me-time and also reduce your screen time which strains both your eyes and brain. Organise your day in a way that by the time you reach home, you are completely off social media.

These small yet highly effective lifestyle changes can do a lot in terms of improving your health, physically and mentally.

(Luke Coutinho, Holistic Lifestyle Coach - Integrative Medicine)

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.

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Alternative therapies to cope with workplace stress – The Sunday Guardian

January 21st, 2020 8:43 am

Therapies like yoga, meditation, mindfulness and sound healing programmes can help us manage work-realted stress, which often translates to ill health and low productivity levels.

Increasing job uncertainty, grueling work hours and an abject lack of work-life balance often translates to heavy stress in our professional lives. Rapidly changing nature of jobs, 24/7 connectivity and the resultant pressure of constant deadlines have turned Indian workplaces into pressure cookers where thousands of young professionals struggle to maintain mental balance. Rates of burnout or exhaustion syndrome are high among bright professionals who fail to reach their full potential because stress gets the better of them on their way to success. A survey by insurance company Cigna TTK found that a whopping 89% of people were suffering from stress, with work and finances being the primary causes of stress.

Interestingly, a number of corporate organisations have realised the negative impact stress is having on their employee productivity, and holistic wellness programmes have gained much traction. However, it is important to educate people at individual levels as well to learn to cope with stress on a daily basis. While we cannot change the stressors, we encounter every day, we can most certainly change the way our mind deals with them.

A number of alternative therapies can help individuals achieve better mental health and wellness. These therapies can be adopted as a way of lives as coping mechanisms for the mind. A study published in the BMC Complementary and Alternative Medicine journal concluded that yoga, mindfulness-based cognitive therapy and cognitive behavioural therapy were very effective in promoting overall mental health and preventing burnout due to work-related stress among participants.

Lets take a look at some alternative therapies that can help you cope with professional stress:

Mindfulness:

Mindfulnessis a psychological process through which one tries to maintain complete awareness of the present moment. It trains the mind to prevent distractions of the future or past musings. Achieving a moment-by-moment awareness of our thoughts, feelings, acts, sensations as well as the environment plays a very impactful role in reducing stress. When you are bathing, you are focusing completely on the act of water interacting with your body; when you are eating, you are doing it so mindfully that all your thoughts are focused on your movement from the plate to the palate and beyond. A study published in theJAMA Internal Medicinereview found that a mindfulness-based programme helped reduce anxiety symptoms in people with generalised anxiety disorder. Another study published in the journalBiological Psychiatry found significant changes to the brain on scans after just three days of mindfulness meditation on 35 unemployed people experiencing major stress of a job search.

Mindfulness works by inducing a sense of calmness and improving focus. Mindfulness is even associated with lower levels of inflammation markers.

Yoga:

Yoga and meditation are widely known to induce benefits for mental health including stress management. Yoga combines the physical and mental disciplines to help achieve a peaceful alignment between the body and mind. When combined with meditation, yoga relaxes and soothes the nerves, aligns the mind towards a calm centre and helps an individual become more mindful of the present. Approach has significant benefits for stress and anxiety. Yoga doesnt just help in stress management, it also helps curtail the negative impact of stress on the body and reduces risk factors for chronic diseases, such as heart disease and high blood pressure. Yoga modulates the stress response systems by training the mind to perceive stress and anxiety differently.

Sound Healing:

Sound healing or music therapy is another highly under-utilised therapy that has significant benefits on stress and anxiety healing. It can effectively be termed as vibrational medicine with the use of music, singing, and sound tools that release vibrations to better the mental, emotional and physical state of a person. Sound healing creates a shift in our brainwave state by using entrainment; a bio-musicological sense that refers to the synchronisation (e.g. foot tapping) of humans to an external perceived rhythm such as music and dance. Entrainment creates a stable frequency in the brain. This allows for the mind to go from the normal beta state (normal waking consciousness) to the alpha state (relaxed consciousness). Quite similar to meditation which regulates the breath, sound healing influences the shift in the brain through its frequency.

Sound healing particularly helps in reducing anxiety, stress, and sleep disorders. A study published in the Journal of Evidence-based Integrative Medicine examined the impact of sound meditation, specifically Tibetan singing bowl meditation, on mood, anxiety, pain, and spiritual well-being. It found participants experienced a significant reduction in tension and feeling of spiritual well-being also significantly increased through sound healing.

The author is the director, Poddar Wellness Ltd and managing trustee, Poddar Foundation

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AI Will Give Rise To FinTech 2.0 And Longevity Banks – Forbes

January 21st, 2020 8:42 am

In the next several years, FinTech, AI, and data-driven technologies will converge into a single ... [+] advanced technology

Over the past 100 years the financial industry has largely excluded people in retirement. Even today tech entrepreneurs are ignoring financial inclusion for people over 60, who make up the wealthiest part of the financial system, and instead, are developing new financial products designed for younger people. The most valuable and capable client demographic in terms of purchasing power are the citizens of the 7th Continent which is made up of 1 billion people over 60. The global spending power of this demographic is expected to be $15 trillion this year. Who will serve this market? Longevity Banks and FinTech 2.0 services will attract people 60+ who want to optimize their wealthspan.

In the last 10 years investment in the FinTech industry has exceeded $350 billion dollars. During the same period a similar amount of funding was invested in other industries such as AI, healthcare, and aerospace.There have been a number of breakthroughs in these other areas but not in FinTech. The amount of money invested in FinTech has not yielded significant results compared to other domains. FinTech received more investment but accomplished less with it and FinTech stalled.However, recent advances in the development of practical AI tools are enabling new FinTech solutions.

The 7th Continent - 1 billion people in retirement

Progressive governments and businesses understand that whole populations are living much longer than in previous generations and realize that we are going to need institutions that are organized in a different way. For example, traditional banks werent designed to serve large numbers of clients living a long, long time. Today, banks have a small number of clients who are over 90 and they are outliers. In the next decade that demographic will increase dramatically.

In the next few years, age-friendly FinTech companies and Longevity Banks will develop new financial products designed for clients who are planning to live extra long lives and want to remain high functioning and financially stable throughout. Clients of Longevity Banks will have more time to accumulate wealth, will have a longer investment horizon, and will benefit from compounding. Financial services innovators have an opportunity to enhance the financial lives of a billion people by designing new solutions and adapting existing products and services. New products that provide a comprehensive view of investments, taxes, insurance, and regulation without unneeded complexity will appeal to citizens of the 7th Continent.

Rising hubs for the new financial industry.

The Intersection of Longevity and Finance

This map shows the location of major preventive medicine and financial hubs. London and Singapore are distinguished as being hubs for both the financial industry and the preventive medicine industry. As such they have extremely strong potential to become global leaders in Longevity and Finance. When these industries intersect, novel financial systems will be developed that will treat Longevity as a dividend and will play an integral role in the Longevity Economy. The most advanced FinTech 2.0 technology adjusted for Longevity is emerging in London and tools for FinTech 2.0 are already in development there.

The Longevity AI Consortium at Kings College London is developing sophisticated methods for translating advanced AI for Longevity solutions including novel applications of life data for insurance companies, pension funds, healthcare companies, and government bodies. This year theConsortium is planning to expand to Switzerland, Israel, Singapore, and the US. Progressive investment banks, pension funds, and insurance companies are developing new business models, and are using AI to improve the quality of the analytics used to formulate them. In the near future, the synergy between innovative AI and wealth management will lead to the creation of new financial institutions optimized for the aging population and age-friendly Longevity Banks will make banking easier and safer for seniors.

Longevity Valley

These developments will result in the emergence of a Longevity Valley with the highest concentration of robust preventive medicine, HealthTech, Longevity FinTech, and AgeTech. The most likely place for the first Longevity Valley is Switzerland because Switzerland is extremely stable in terms of financial, social, and political frameworks. Switzerland was also recently recognized by the United Nations as the most AgeTech friendly country. The Longevity Valley will attract people who prioritize maximizing their healthspan and wealthspan. The first Longevity Bank is also expected to emerge in Switzerland since the pillars needed for the success of such a bank are present there. These pillars include a progressive RegTech environment, sufficient FinTech development, a MedTech ecosystem, and a significant number of individuals 60+ who fit the client profile.

In the near future, FinTech, AI, and data-driven technologies will converge into a single advanced technology. Next generation financial companies will use engineering methods with integrated systems to treat business, finance and technology as a single unit with complementary parts. The resulting FinTech 2.0 will offer unprecedented potential for growth and disruption.Humans have always desired health, wealth, and longevity, but usually had to settle for one or two. For the first time people are planning for a very different future with the possibility of living to 100 and beyond and being healthy and financially stable the whole time.

Click here to preview a new book that I co-authored with my colleague Dmitry Kaminskiy Longevity Industry 1.0 - Defining the Biggest and Most Complex Industry in Human History. Dmitry Kaminskiy and I serve on the advsiory board of the Longevity AI Consortium at Kings College London.

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Walking, Running Or Swimming: Which Exercise Is The Best For Longevity? – International Business Times

January 21st, 2020 8:42 am

KEY POINTS

It has been long-established that exercising frequently can do wonders for your health, including boosting life expectancy. The National Health Service stated that regular exercise lowers your risk of dying early by up to 30%.

Many studies have proven that those who exercise regularly are at a lower risk of developing a host of chronic ailments. These researches have also shown how performing physical activities can improve your mood, energy, self-esteem, and sleep quality. With many types of exercises, however, which is considered the best one to improve life expectancy?

The Best Exercise For Longevity

In research where more than 40,000 men between 20 and 90 years old participated, researchers monitored their activities for 32 years. At the end of the study, researchers found that swimmers are at a 50% lower risk of dying young compared to walkers or runners. swimming best exercise longevity Photo: 12019 - Pixabay

Steven Blair, the lead researcher and a University of South Carolina professor of exercise science, expressed surprise at the result. He had expected to see both runners and swimmers enjoying lower risk of dying. It turned out that swimmers enjoy a considerably lower death rate compared to runners.

The Reason

Researchers established that while swimming is extremely aerobic, it does not cause much strain on the lower joints compared to walking or running. This is why swimming provides your health with more benefits than the other two types of exercises.

The lead researchers also found that regular swimmers enjoy higher cardiorespiratory fitness compared to walkers and people who lead sedentary lives.Blair concluded that swimming provides you with a healthful alternative, as compared to traditional exercise modes, for improving your cardiorespiratory fitness. It is also the best way to maintain overall health and provides the most benefits for patients who have chronic ailments.

He also said that swimming is a great alternative exercise for those who are unable to engage in physical activities like running or other forms of physical endeavors. The findings of the research were published in the International Journal of Aquatic Education and Research.

Dr. I-Min Lee of the Harvard Medical School agrees, saying swimming is the perfect workout. The professor of medicine explained that swimming is best for arthritic patients because it is essentially a weight-bearing exercise.

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The Longevity Of Classic Design In Fashion: Why Jeff Rudes’ Brands Are Built To Last – vmagazine.com

January 21st, 2020 8:42 am

Fashionespecially denimis like the stock market, says JeffRudes, the visionary co-founder of J Brand and the majority owner of powerhouse ready to wear brand LAgence.

Thats why you can always rely on customer demand coming back to refined, classic, and purist design principles. Such design principles have always been hallmarks of Rudes labels. J Brandfor instancebecame the universal gold standard in high fashion due to its classic dark blue denim jeans.

While trends and outliers have their moments, there will always be demand for a baseline of a high quality, clean and refined aesthetic. This baseline, after all, is what enables the market to reset itself and provides customers a reliable anchor to attach themselves to.

And since the market will always come back to this foundation,Rudes LAgence is now perfectly positioned to be a long-term market force in Fashion and write its own Chapter of Fashion History.

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Diet Demand Touts Benefits of Heart Healthy Diets for Longevity and Weight Loss – Yahoo Finance

January 21st, 2020 8:42 am

Baton Rouge, LA, Jan. 20, 2020 (GLOBE NEWSWIRE) -- If youre looking to start 2020 with a leap towards a healthier lifestyle, a heart-healthy diet is one of the best places to start. Heart healthy diets can go a long way toward protecting and preserving your bodys most important muscle. They also tend to have an obviously, positive impact on the rest of the body and mind. A focus on heart healthy eating is one way to promote longevity, youthfulness and weight control in your own life. Currently, a few popular heart healthy options stand out the most according to telemedicine weight loss leader, Diet Demand.

TheDASHDiet. According to Dr. Burns - Diet Demands Medical Director, DASH was created as a way to lower blood pressure based on the theory of sodium causing hypertension. It stands for Dietary Approaches to Stop Hypertension and works for a percentage of the population who are hypertensive. For these sodium sensitive individuals (maybe only 25% of the population), this method can provide some benefit. It also helps to restore some mineral imbalances that contribute to high blood pressure. However, Dr. Burns believes that there is more to improving heart health, Avoiding processed foods are sound, however the guidelines on specific macronutrient intake are missing. Also, weight management should be a key aspect of heart healthy dieting. Being that DASH was created for hypertension, the primary purpose of this diet is not weight management. As far as weight loss is concerned, only lower calorie versions of DASH would trigger weight loss, but that would apply to them doing any lower calorie diet. Additionally, for people who are following lower carb diets for weight loss, the sodium requirement actually goes up, along with the other electrolytes of potassium and magnesium due to the effect of the kidneys wasting electrolytes more rapidly while the body goes into ketosis. Believe it or not, the daily sodium requirement is actually higher on a lower carb diet than a high carb diet.

The Mediterranean diet is also touted for its heart-healthy benefits. Unlike the DASH diet whose primary purpose is the reduction of salt, Mediterranean style eating is more heavily focused on the incorporation of heart-healthy omega3s and fats such as olive oil, fatty fish and avocados. Since whole foods are implemented, sodium reduction is somewhat a part of this diet since processed foods are minimized. Diet Demand, a nationally recognized virtual weight loss program incorporates heart-healthy strategies in its customized diet and weight loss coaching methods. Its Jumpstart Diet, focuses is on balanced nutrition and initial calorie reductions between 800-1200 calories to help patients at risk for heart disease with quick weight loss.

Diet Demand provides certified weight loss doctors and coaches available by phone 24/7 to help with meal planning, grocery shopping, dining out and more. Theres nothing better than having personalized help via certified weight loss professionals who can review your plan and help you along the way.

A better solution. Most diets have a one-size-fits-all strategy, so its assumed that what works for some people will work for you as well. Unfortunately, many factors can determine how well a specific diet works for you. Diet Demand takes a personalized approach by gathering information on your individual body macros in order to develop a diet that is specific to your needs. Due to the success of this customized model, Diet Demand clients have a 94 percent success rate.

See what Diet Demand can do for you by easily and effortlessly visiting http://www.dietdemand.com/ to complete an initial comprehensive, yet simple, health questionnaire and schedule an immediate personal, no-cost consultation. DietDemands physicians all received specialized training in nutritional science and fast weight loss. DietDemand reviews each patients health history to create a personalized diet plan geared for fast weight loss, or that addresses life-long issues causing weight loss to slow down or stop. Nutritionists work personally with each patient and use their own algorithm to craft meal and snack plans that are compatible with each patients age, gender, activity level, food preferences, nutritional needs and medical conditions. They combine these state-of-the-art diet plans with pure, prescription diet products that enable their patients to resist the temptation to reach for sugary snacks, eliminate fatigue and curb the appetite. Over 97% of DietDemand patients report incredible weight loss results with the majority losing 20 or more pounds per month.

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At DietDemand, all patients gain unlimited access to the best minds in the business. Their staff of doctors, nurses, nutritionists and coaches are available six days per week to answer questions, offer suggestions, address concerns and lend their professional guidance and support. Because of this, more and more people are turning to DietDemand for their weight management needs. Diet plans are tailored to be specific to the needs of those of any age, gender, shape or size and for those who are struggling to lose that final 10-20 pounds to those who must lose 100 pounds or more. Call today to request a private, confidential, no-cost online consultation.

About the Company:

DietDemand is the nation's leader in medical, weight loss offering a full line of prescription medication, doctor, nurse and nutritional coaching support. For over a decade, DietDemand has produced a sophisticated, doctor designed weight loss program that addresses each individual specific health need to promote fast, safe and long-term weight loss.

DietDemand Providing Care Across The USA

Headquarters:

Escondido, CA

(888) 786-9568

info@dietdemand.com

http://www.dietdemand.com/

Diet DemandDietDemand888-786-9568info@dietdemand.com

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Could This Type Of Community Boost Longevity & Eradicate Loneliness? – mindbodygreen.com

January 21st, 2020 8:42 am

However, these studies also face the issue of replicability, and causal associations are difficult to draw. For instance, earlier this month, a study led by Jason Chen, Ph.D., of the Center to Improve Veteran Involvement in Portland, was published in Social Psychiatry and Psychiatric Epidemiology. They found that, counterintuitively, among veterans, loneliness was associated with lower depression severity. This has prompted study authors to more closely examine the role of social support interventions.

"We are currently looking at interventions that are not only relevant to veterans just at our hospital but also in other settings," Chen said. "In addition, our study team is interested in emphasizing the potential for loneliness interventions for our more rural, isolated populations in Oregon and beyond."

Reza Ghomi, M.D., is a Seattle-based neuropsychiatrist who sees firsthand how social support alone can have a dramatic impact on emotional well-being.

"Social isolation has dramatic effects not only on mental health such as increasing risks for depression and anxiety, but now we are seeing it can increase risk for cognitive impairment and ultimately dementia," Ghomi said. "Building community does the reverse and promotes a sense of well-being and satisfaction including improvement in cognitive abilities."

When it comes to the medical community, at a time when burnout was just named as one of the biggest challenges in health care by a Lancet report, finding supporting environments remains key among health care providers. Dana Correil, M.D., an internist and co-founder of SoMeDocs ("social media doctors"), points to the benefits of her "moai" being centered around a shared interest in advocacy and health care communication.

"For doctors, social media can be a space for connection, a powerful tool to mitigate the loneliness epidemic," Correil said. "It allows us to exchange ideas, find camaraderie and perspective for issues challenging our profession today and provides us with opportunities to make actual change."

And the opportunity for doctors to connect offline have flourished: everything from storytelling workshops like the Nocturnists, narrative medicine programs to Schwartz rounds help build community around shared vulnerability.

They say it takes a village to raise a child. But, as the science suggests, the health and well-being of all of us may benefit from having our own village, or moai: at home, work, and everywhere in between.

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Live Longer And Healthier By Regularly Doing This Simple Activity – International Business Times

January 21st, 2020 8:42 am

KEY POINTS

For many years, the human race has been on a quest for ways to improve longevity. Through scientific studies, researchers were able to point out unhealthy practices that you should get rid of to enjoy a longer life. Some of these include quitting smoking as the habit increases your risk of developing several serious ailments like cancer. Although avoiding known unhealthy lifestyle practices play a vital role in achieving longevity, there is a connection between enjoying simple past-times and longevity.

Own a Dog

A new study published in Circulation: Cardiovascular Quality and Outcomes reveals that owning a dog has been associated with living a longer life. It also showed that those who own dogs also have better cardiovascular activities. Those who live alone and have had bouts with a heart attack and stroke are advised to indulge in such activity. dog ownership longevity lifestpan Photo: MabelAmber - Pixabay

The outcome in the published study was based on two other studies, which showed that dog ownership was associated with a reduction in the factors that play a role in cardiac arrest and other heart-related events.

As a result, since cardiac arrest and cardiovascular events are reduced, the mortality rate associated with these diseases is likewise reduced. Although these studies do not necessarily prove that dog ownership is linked to lower mortality rates, the results clearly suggest this.

Other Benefits Of Dog Ownership

According to previous studies, by owning a dog, social isolation is alleviated. It also helps improve physical activity and also helps in lowering blood pressure. They also found that this is very much evident among dog owners as compared to those who dont own one.

The study looked into the data that was provided by the Swedish National Patient Register. Swedish residents aged between 40 to 85 years old became part of the study. They were the ones who experienced a stroke or a heart attack.

Out of these residents, it was found that those who owned a dog were said to have a lower risk of death thereafter. The possible reasons pointed out include decreased loneliness and depression. They also had better socialization because of their dogs. Furthermore, it was found that by owning a dog, they are better motivated to keep themselves active and physically fit.

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NMN Benefits – The Path of Longevity – ProHealth

January 21st, 2020 8:42 am

Gauging the benefits of NMN, or any supplement, medicine, or treatment regimen can be a bit tricky if done without the benefit of scientific methods and testing standards.

Treatments, and human perception itself, can be influenced by several factors. If we make changes to our diet or lifestyle routine while using a particular herb or vitamin, for example, was it the supplement that produced the perceived effects, or was it those salads?

Perhaps it was just our own mind, convinced that the supplement would produce a particular benefit. This mental ability to influence a treatment regimens outcome is called the placebo effect. The placebo effect can account for a large portion of any treatments success or failure, which is why many research studies are designed to minimize it.

Another dynamic at play to consider is a persons perception and evaluation of a particular treatment, called anecdotal evidence. Anecdotal evidence, while not considered reliable by scientists, is nonetheless a common feature of day-to-day health care. If your doctor prescribes a medicine or supplement, and then later asks, What happened?, he or she is asking for anecdotal evidence

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Gene Therapy Market Worth $13.0 Billion by 2024 – Exclusive Report by MarketsandMarkets – Yahoo Finance

January 21st, 2020 8:41 am

CHICAGO, Jan. 20, 2020 /PRNewswire/ -- According to the new market research report "Gene Therapy Marketby Vectors [Non-viral (Oligonucleotides), Viral (Retroviral (Gammaretroviral, Lentiviral), Adeno-associated], Indication (Cancer, Neurological Diseases), Delivery Method (In Vivo, Ex Vivo), Region - Global Forecast to 2024", published by MarketsandMarkets, is projected to reach USD 13.0 billion by 2024 from USD 3.8 billion in 2019, at a CAGR of 27.8% from 2019 to 2024.

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Download PDF Brochure: https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=122857962

The high incidence of cancer and other target diseases, availability of reimbursement, and the launch of new products are the major factors driving the growth of the market.

The non-viral vectors segment accounted for the largest share of the market, by vector, in 2018

The Gene Therapy Market, by vector, has been segmented into viral and non-viral vectors. Non-viral vectors accounted for the largest share of the market in 2018. This is mainly attributed to the high market penetration of oligonucleotide-based non-viral vector gene therapies.

Browsein-depth TOC on "Gene Therapy Market" 127 - Tables25 - Figures 129 - Pages

The demand for gene therapies for the treatment of cancer is expected to grow at a high rate

Based on indication, the market is segmented into neurological diseases, cancer, hepatological diseases, Duchenne muscular dystrophy, and other indications. The neurological diseases segment accounted for the largest share of the market in 2018. However, the cancer segment is estimated to grow at the highest CAGR during the forecast period owing to the increasing incidence of cancer and the rising demand for CAR T-cell therapies.

Get 10% Customization Research Report: https://www.marketsandmarkets.com/requestCustomizationNew.asp?id=122857962

North America is the largest regional market for gene therapy products

The global Gene Therapy Market is segmented into North America, Europe, the Asia Pacific, and the Rest of the World. In 2018, North America accounted for the largest share of the market, followed by Europe. Moreover, the North American market is estimated to register the highest growth rate during the forecast period. Factors such as the rising prevalence of chronic diseases, high healthcare expenditure, presence of advanced healthcare infrastructure, favorable reimbursement scenario, and the presence of major market players in the region are driving market growth in North America.

The prominent players operating in the Gene Therapy Market include Biogen (US), Sarepta Therapeutics, Inc. (US), Gilead Sciences, Inc. (US), Novartis AG (Switzerland), Amgen, Inc. (US), Spark Therapeutics, Inc. (US), MolMed S.p.A. (Itlay), Orchard Therapeutics plc. (UK), Sibiono GeneTech Co. Ltd. (China), Alnylam Pharmaceuticals, Inc. (US), Human Stem Cells Institute (Russia), AnGes, Inc. (Japan), Dynavax Technologies (US), Jazz Pharmaceuticals, Inc. (Ireland), and Akcea Therapeutics (US).

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Novel form of cell-free therapy revealed by researchers – Drug Target Review

January 21st, 2020 8:41 am

Researchers have developed cytochalasin B-induced membrane vesicles which they suggest could be a new form of cell-free therapy in regenerative medicine.

Work on extracellular microvesicles (ECMVs) derived from human mesenchymal stem cells (MSCs) has revealed a potential new form of cell-free therapy.

ECMVs are microstructures surrounded by a cytoplasm membrane; they have proven to be a prospective therapeutic tool in regenerative medicine due to their biocompatibility, miniature size, safety and regenerative properties. These can be used to circumvent the limitations of existing cell therapies without losing any effectiveness.

Cell therapies are grafts or implants of living tissue, such as bone marrow transplants, used to replace and regenerate damaged organ tissue. They currently have limited applications, as they work differently dependent on conditions and the environment they are placed into. They can also be rejected by the immune system.

A study at Kazan Federal University, Russia, has investigated cytochalasin B-induced membrane vesicles (CIMVs) which are also derived from MSCs and are very similar to natural ECMVs.

Proteome analysis of human MSCs and CIMVs-MSCs. Venn diagram of identified proteins MSCs and CIMVs-MSCs (A). Distribution of the identified proteins in organelles, percent of unique identified proteins (B) (credit: Kazan Federal University).

The scientists studied and characterised the biological activity of MSC-derived CIMVs. A number of biologically active molecules were found in CIMVs, such as growth factors, cytokines and chemokines; their immunophenotype was also classified.They also found that CIMVs could stimulate angiogenesis in the same way as stem cells.

The team came to the conclusion that human CIMVs-MSCs can be used for cell-free therapy of degenerative diseases. Induction of therapeutic angiogenesis is necessary for the treatment of ischemic tissue damage (eg, ischemic heart disease, hind limb ischemia, diabetic angiopathies and trophic ulcers) and neurodegenerative diseases (eg, multiple sclerosis and Alzheimers disease), as well as therapies for damage of peripheral nerves and spinal cord injury.

The group say they are continuing to research the therapeutic potential for artificial microvesicles for autoimmune diseases.

The study was published in Cells.

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Xenobots are here: Tiny bio-robots inside your veins may heal you & will definitely be weaponized by West to take out bad guys – RT

January 21st, 2020 8:41 am

Peter Andrewsis an Irish science journalist and writer, based in London. He has a background in the life sciences, and graduated from the University of Glasgow with a degree in Genetics

Xenobots tiny, biological robots swarms designed by a computer are upon us. What does the birth of these strange not-quite-alive creatures mean for robotics and for us?

Mankind has been imagining advanced robot technology for a long time pop culture is full of Terminators, Cylons, and Droids. But in fact, these humanoid designs show a distinct lack of imagination. Why have we always assumed that robots would be designed to have the same basic form as us: slightly ungainly primates trotting about on two feet, perhaps even toting a gun? The latest models make that particular notion look a bit 1950s.

One such model are the fearsome xenobots unleashed by American scientiststhis week. These are biological robots less than a millimetre wide, that can move, release a payload and repair themselves. Grown from stem cells (cells that can turn into any type of body cell) that were cut into specific shapes designed by a supercomputer, they can swim inside the human body for weeks on end, working together to achieve a task.

They can walk and swim, meaning they are just one sport short of a triathlon. On top of all this, they have one more superpower Wolverines healing factor. Well, it may not be ripped from Marvel comics, but they can repair themselves without any help. And when the poor little xenobots reach the end of their short but glorious lives (are they alive?) inside your body, you can rest easy with the thought that since they are entirely organic, they will biodegrade naturally. What could be more comforting than artificial creatures dying inside your veins made of nothing but harmless African clawed frog DNA?

Jokes aside, this is an astonishing leap forward in the game of playing God. But who exactly is the Dr Frankenstein to these xenobot monsters? Unnervingly, their specific shapes they come in a range of shapes that look a bit like Tetris blocks were designed not by the clever scientists, but rather by a supercomputer.

It did this via a kind of xenobot Battle Royale, in which tons of randomly-assembled designs faced off within a simulation to cull the weakest and mutate the strongest. Some of the winning forms are c-shaped, some triangular and there is even a doughnut-shaped one with a hole in the middle. But these are just the ones that made it to the final iteration. One wonders if they could be made to form any shape, like letters of the alphabet xenobot soup could be a big hit, if only they were a bit bigger. (Besides, meat grown from frog embryos cannot be the tastiest. Silly idea anyway.)

So xenobots, in a nutshell, are a swarm of invisible genetically engineered semi-sentient robots designed by an artificial intelligence to live in the human body for days or weeks at a time, where they can survive without food and heal themselves if damaged. What could go wrong?

Well, probably nothing for now. But the arms race to develop xenobots for new applications is already underway, and militaries will certainly be eager to deploy them carrying biological weapons. The supercomputer that designed the xenobots was not available for comment.

Looking at the xenobots, I knew they were reminding me of something that I couldnt put my finger on. At last, it hit me: the little guys bear a striking resemblance, both in colour and texture, to the titular villain in the 1958 Hollywood blockbuster The Blob. The only difference being of course that blessedly, the xenobots are less than a millimetre wide, and therefore present no menace to small American towns. But what if one of the team went mad and tried to create one massive xenobot, one that could open car doors and absorb teenagers? Heres hoping the supply of African clawed frog embryo stem cells is running low in their labs. Apparently, the xenobots were named after Xenopus laevis, the frogs Latin name. Can it be a coincidence, then, that the prefix xeno-is Greek for strange, foreignor alien? Either way, it suits these new life forms perfectly.

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Mesenchymal Stem Cells Market in 2020: Global Industry Size, Demand, Growth & Development, Trends, Insights and Forecast until 2024. How’s the…

January 21st, 2020 8:41 am

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Precision Health Informatics and Concerto HealthAI to Collaborate on Advanced Precision Medicine Solutions – Yahoo Finance

January 20th, 2020 5:49 am

Concerto HealthAI's Real-World Data analytical capabilities will enable Precision Health Informatics to accelerate innovation in cancer testing and treatment

DALLAS and BOSTON, Jan. 14, 2020 /PRNewswire-PRWeb/ --Concerto HealthAI, the market leader for Real-World Data (RWD) and enterprise AI technology, announced today an agreement with Precision Health Informatics, a subsidiary of community-based cancer care pioneer Texas Oncology, to accelerate the advancement of precision medicine to treat cancer patients. Precision Health Informatics will work with Concerto HealthAI to advance RWD solutions, research studies, and AI-enabled technologies focusing on genomic and molecular characterization of patient disease to develop effective new therapies to treat some of the most challenging and devastating cancers.

Precision Health Informatics will leverage Concerto HealthAI's eurekaHealth 3.0 enterprise AI solution to advance precision medicine solutions for clinical research. Using AI models to enrich clinical data, Precision Health Informatics will more quickly derive insights from patient data to inform new study designs or identify eligible patients for clinical studies. Precision Health Informatics joins an expanding set of Concerto HealthAI's Real-World Evidence collaborators, such as theAmerican Society of Clinical Oncology's CancerLinQ relationship announced in late 2017.

"Precision Health Informatics' model uses information from the molecular profile representing the genetics of the patient's disease combined with the clinical information specific to that patient to develop personalized medicine solutions that are integral to diagnosing cancer and offering physicians and patients effective treatment options," said Lori Brisbin, Vice President for Precision Health Informatics, "Concerto HealthAI's leadership in solutions for precision medicine will help us derive more meaningful insights from patient data, that in turn may help us connect patients with appropriate clinical trials."

"Using data from Texas Oncology's large patient base, Precision Health Informatics is at the forefront of precision medicine, innovative cancer testing and diagnostic approaches, such as Next Generation Sequencing changing and improving the standard of care for patients. Ultimately, this is all about developing and connecting cancer patients to precise, effective treatment," said R. Steven Paulson, MD, President of Precision Health Informatics, and President and Chairman of Texas Oncology. "Concerto HealthAI's deep expertise in research-grade RWD solutions and AI technologies make it the ideal collaborator with Precision Health Informatics to help us more quickly develop medical innovations that benefit patients in our practice and elsewhere."

"At Concerto HealthAI, we seek clinical collaborators committed to advancing insights and new treatment strategies for patients with the highest unmet medical needs," said Jeff Elton, PhD, CEO of Concerto HealthAI. "Precision Health Informatics is making a deep commitment to enabling precision medicine, which we see as highly complementary to the work of our biomedical innovator partners."

This collaboration will advance novel research solutions, integrating deep clinical insights derived from electronic medical record data, particularly information about the molecular basis of disease derived from tissue or liquid samples. The value of these insights in helping connect patients to effective treatment options will be made available to Texas Oncology patients through its precision medicine program.

About Concerto HealthAI Concerto HealthAI is a technology leader in Definitive Real-World Data (RWD) and AI solutions for Precision Oncology. Our mission is to bring together unique data assets, leading AI-based technologies, and the world's top outcomes research and data science talent. Our focus is on revolutionizing clinical and outcomes research to accelerate the insights benefitting patient treatment. For more information, visit us at http://www.concertohealthai.com.

About Precision Health Informatics and Texas Oncology Precision Health Informatics, a subsidiary of Texas Oncology, is a precision medicine solutions company that uses patients' genetic information for innovative testing, diagnostics, and treatment of cancer. Precision Health Informatics' solutions are based on data-driven insights from a vast, diverse patient base. Texas Oncology is an independent private practice with more than 460 physicians and 210 locations across the state. Meeting the oncology needs of Texans for more than 35 years, the practice includes Texas Center for Proton Therapy, Texas Breast Specialists, Texas Oncology Surgical Specialists, and Texas Center for Interventional Surgery. As a lead participant in US Oncology Research, Texas Oncology played a role in the development of more than 90 FDA-approved therapies, about one-third of all cancer therapies approved to date. For more information, visit http://www.texasoncology.com.

MEDIA CONTACTS

Jen Toole Concerto HealthAI 617.779.1828 jtoole@shiftcomm.com

Ed Bryson Texas Oncology 512.592.8190 edward.bryson@usoncology.com

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Moderna Partners with AWS to Explore the ‘Software of Life’ – BioSpace

January 20th, 2020 5:49 am

The software of life. Thats how Stephane Bancel, the chief executive officer of Moderna, described messenger RNA (mRNA), which is at the core of Modernas drug development process.

Moderna is pioneering mRNA drugs that are believed to be able to direct the body to produce any protein of interest, including antibodies and other proteins that can create therapeutic activity. Bancel said mRNA is an information molecule.

Its like software, he said.

The company, which has secured enormous investments over the past few years, is inching closer to being a commercial company in developing personalized therapies for a wide range of diseases, including cancer. In order to create those personalized medicines, the Cambridge, Mass.-based company relies on gene sequencing and a partnership with one of the worlds largest companies Amazon.

In an interview with CNBCs Jim Cramer during the J.P. Morgan Healthcare Conference this week, Bancel said the company relies on Amazon Web Services to compare every letter of DNA in the sequencing process. Once that is done, the company can deduce what needs to be done to develop personalized medicine, Bancel explained.

Amazon Web Services, the fastest growing division of the company, according to CNBC, provides on-demand cloud computing platforms to companies. Moderna is currently using Amazon Web Services with more than a dozen drug candidates in its pipeline, which means the high-tech platform plays a central role in the companys drug development program. As CNBC explains, the company is using the powerful cloud-based service to speed up the time it takes a drug candidate to move from the preclinical to the clinical phase. In addition to Moderna, Amazon Web Services is being used by several pharmaceutical companies, including San Diego-based Human Longevity Inc., Regeneron Pharmaceuticals and more.

The reliance on the high-speed program could lead to the company finally becoming a commercial entity 10 years after it was launched. Last week, just ahead of JPM, Bancel pointed to one of the companys clinical candidates as a potential blockbuster, an experimental treatment for cytomegalovirus (CMV), the most common infectious cause of birth defects in the United States.

Moderna said the analysis following a Phase I trial, which was taken after the third and final vaccination, shows continued boosting of neutralizing antibody titers in patients. The mRNA-based vaccine, mRNA-1647, is designed to protect against CMV infection. Cytomegalovirus is a common pathogen and is the leading infectious cause of birth defects in the United States with approximately 25,000 newborns in the U.S. infected every year. CMV is passed from the mother to her unborn child. Birth defects occur in about 20% of infected babies. The defects can include neurodevelopmental disabilities such as hearing loss, vision impairment, varying degrees of learning disability and decreased muscle strength and coordination. There is no approved vaccine to prevent CMV infection.

In October, the company received Fast Track Designation from the U.S. Food and Drug Administration for mRNA-3927, its investigational mRNA therapeutic for propionic academia, which is caused by the inability of the body to breakdown certain proteins and fats which leads to the build-up of toxic chemicals. Moderna plans to initiate an open-label, multi-center, dose-escalation Phase I/II study of multiple ascending doses of mRNA-3927 in primarily pediatric patients.

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Is Cloud Computing the Answer to Genomics Big Data… – Labiotech.eu

January 20th, 2020 5:49 am

The success of the genomics industry has led to generation of huge amounts of sequence data. If put to good use, this information has the potential to revolutionize medicine, but the expense of the high-powered computers needed to achieve this is making full exploitation of the data difficult. Could cloud computing be the answer?

Over the last decade, genomics has become the backbone of drug discovery. It has allowed scientists to develop more targeted therapies, boosting the chances of successful clinical trials. In 2018 alone, over 40% of FDA-approved drugs had the capacity for being personalized to patients, largely based on genomics data. As the percentage has doubled over the past four years, this trend is unlikely to slow down anytime soon.

The ever-increasing use of genomics in the realm of drug discovery and personalized treatments can be traced back to two significant developments over the past decade: plunging sequencing costs and, consequently, an explosion of data.

As sequencing technologies are constantly evolving and being optimized, the cost of sequencing a genome has plummeted. The first sequenced genome, part of the Human Genome Project, cost 2.4B and took around 13 years to complete. Fast forward to today, and you can get your genome sequenced in less than a day for under 900.

According to the Global Alliance for Genomics and Health, more than 100 million genomes will have been sequenced in a healthcare setting by 2025. Most of these genomes will be sequenced as part of large-scale genomic projects stemming from both big pharma and national population genomics initiatives. These efforts are already garnering immense quantities of data that are only likely to increase over time. With the right analysis and interpretation, this information could push precision medicine into a new golden age.

Are we ready to deal with enormous quantities of data?

Genomics is now considered a legitimate big data field just one whole human genome sequence produces approximately 200 gigabytes of raw data. If we manage to sequence 100M genomes by 2025 we will have accumulated over 20B gigabytes of raw data. The massive amount of data can partially be managed through data compression technologies, with companies such as Petagene, but that doesnt solve the whole problem.

Whats more, sequencing is futile unless each genome is thoroughly analyzed to achieve meaningful scientific insights. Genomics data analysis normally generates an additional 100 gigabytes of data per genome for downstream analysis, and requires massive computing power supported by large computer clusters a feat that is economically unfeasible for the majority of companies and institutions.

Researchers working with large genomics datasets have been searching for other solutions, because relying solely on such high-performance computers (HPC) for data analysis is economically out of the question for many. Large servers require exorbitant amounts of capital upfront and incur significant maintenance overheads. Not to mention, specialized and high-level hardware, such as graphics processing units, require constant upgrades to remain performant.

Furthermore, as most HPCs have different configurations, ranging from technical specs to required software, the reproducibility of genomics analyses across different infrastructures is not a trivial feat.

Cloud computing: a data solution for small companies

Cloud computing has emerged as a viable way to analyze large datasets fast without having to worry about maintaining and upgrading servers. Simply put, Cloud computing is a pay-as-you-go model allowing you to rent computational power and storage. and its pervasive across many different sectors.

According to Univa the industrial leader in workload scheduling in the cloud and HPC more than 90% of organizations requiring high performance computing capacity have moved, or are looking into moving to the cloud. Although this is not specific for companies in the life sciences, Gary Tyreman Univas CEO suggests that pharmaceutical companies are ahead of the market in terms of adoption.

The cloud offers flexibility, an alluring characteristic for small life science companies that may not have the capital on-hand to commit to large upfront expenses for IT infrastructure: HPC costs can make or break any company. As a consequence, many opt to test their product in the cloud first, and if numbers look profitable, they can then invest in an in-house HPC solution.

The inherent elasticity of cloud resources enables companies to scale their computational resources in relation to the amount of genomic data that they need to analyze. Unlike with in-house HPCs, this means that there is no risk money will be wasted on idle computational resources.

Elasticity also extends to storage: data can be downloaded directly to the cloud and removed once the analyses are finished, with many protocols and best practices in place to ensure data protection. Cloud resources are allocated in virtualized slices called instances. Each instance hardware and software is pre-configured according to the users demand, ensuring reproducibility.

Will Jones, CTO of Sano Genetics, a startup based in Cambridge, UK, offering consumer genetic tests with support for study recruitment, believes the cloud is the future of drug discovery. The company carries out large data analyses for researchers using its services in the cloud.

In a partnership between Sano Genetics and another Cambridge-based biotech, Joness team used the cloud to complete the study at a tenth of the cost and in a fraction of the time it would have taken with alternative solutions.

Besides economic efficiency, Jones says that moving operations to the cloud has provided Sano Genetics with an additional security layer, as the leading cloud providers have developed best practices and tools to ensure data protection.

Why isnt cloud computing more mainstream in genomics?

Despite all of the positives of cloud computing, we havent seen a global adoption of the cloud in the genomics sector yet.

Medley Genomics a US-based startup using genomics to improve diagnosis and treatment of complex heterogeneous diseases, such as cancer moved all company operations to the cloud in 2019 in a partnership with London-based Lifebit.

Having spent more than 25 years at the interface between genomics and medicine, Patrice Milos, CEO and co-founder of Medley Genomics, recognized that cloud uptake has been slow in the field of drug discovery, as the cloud has several limitations that are preventing its widespread adoption.

For starters, long-term cloud storage is more expensive than the HPC counterpart: cloud solutions charge per month per gigabyte, whereas with HPC, once youve upgraded your storage disk, you have no additional costs. The same goes for computing costs: while the cloud offers elasticity, Univas CEO Tyreman says that the computation cost of a single analysis is five times more expensive compared to an HPC solution in many scenarios. However, as cloud technologies continue to progress and the market becomes increasingly more competitive among providers, the ongoing cloud war will likely bring prices down.

Furthermore, in the world of drug discovery, privacy and data safety are paramount. While cloud providers have developed protocols to ensure the data is safe, some risks still exist, for example, when moving the data. Therefore, large pharmaceutical companies prefer internal solutions to minimize these risks.

According to Milos, privacy remains the main obstacle for pharmaceutical companies to fully embrace the cloud, while the cost to move operations away from HPCs is no longer a barrier. While risks will always exist to a certain extent, Milos highlighted that the cloud allows seamless collaboration and reproducibility, both of which are essential for research and drug discovery.

Current players in the cloud genomics space

Cloud computing is a booming business and 86% of cloud customers rely on three main providers: AWS (Amazon), Azure (Microsoft) and Google Cloud. Although the three giants currently control the market, many other providers exist, offering more specialized commercial and academic services.

Emerging companies are now leveraging the technology offered by cloud providers to offer bioinformatics solutions in the cloud, such as London-based Lifebit, whose technology allows users to run any bioinformatics analyses through any cloud provider with a user-friendly interface effectively democratizing bioinformatics for all researchers, regardless of skill set.

Federation is a concept from computing now used in the field of genomics. It allows separate computers in different networks to work together to perform secure analysis without having to expose private data to others, effectively removing any potential security issues.

The amount of data organizations are now dealing with has become absolutely unmanageable with traditional technologies, and is too big to even think about moving, explained Maria Chatzou Dunford, Lifebits CEO and co-founder.

When data is moved, you increase the chances of having it be intercepted by third-parties, essentially putting it at significant risk. Data federation is the only way around this unnecessary data storage and duplication costs, and painstakingly slow data transfers become a thing of the past.

Getting ready for the genomics revolution

Its no secret that genomics is key to enabling personalized medicine and advancing drug discovery. We are now seeing a genomics revolution where we have an unprecedented amount of data ready to be analyzed.

The challenge now is: are we ready for it? To be analyzed, big data requires massive computation power, effectively becoming an entry barrier for most small organizations. Cloud computing provides an alternative to scale analyses, while at the same time, facilitating reproducibility and collaboration

While the cost and security limitations of cloud computing are preventing companies from fully embracing the cloud, these drawbacks are technical and are expected to be resolved within the next few years.

Many believe that the benefits of the cloud heavily outweigh its limitations. With major tech giants competing to offer the best cloud solutions a market valued at $340 billion by 2024 we might be able to expect a drastic reduction in costs. While some privacy concerns may still exist, leading genomics organizations are developing new tools and technologies to protect genomic data.

Taken as a whole, it is likely that the cloud will be increasingly important in accelerating drug discovery and personalized medicine. According to Univas Tyreman, it will take around 1015 years to see the accelerated transition from HPC to cloud, as large organizations are often conservative in embracing novel approaches.

Distributed big data is the number one overwhelming challenge for life sciences today, the major obstacle impeding progress for precision medicine, Chatzou Dunford concluded.

The cloud and associated technologies are already powering intelligent data-driven insights, accelerating research, discovery and novel therapies. I have no doubt we are on the cusp of a genomics revolution.

Filippo Abbondanza is a PhD candidate in Human Genomics at the University of St Andrews in the UK. While doing his PhD, he is doing an internship at Lifebit and is working as marketing assistant at Global Biotech Revolution, a not-for-profit company growing the next generation of biotech leaders. When not working, he posts news on LinkedIn and Twitter.

Images via E. Resko, Lifebit and Shutterstock

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Leadership in the Age of Personalization is About Creating Healthy Environments So People Can Thrive – Forbes

January 20th, 2020 5:49 am

This is Part 8 of an eight-part series featuring thought-provoking insights from theLeadership in the Age of Personalization Summit. Here is Part 1, Part 2, Part 3, Part 4, Part 5, Part 6 and Part 7.

All Employers are in the Business of Health

My definition of harmony is when your head, your heart, your feet, and your gut are all going in the same direction.

I love that quote. In the context of business, we could think of the head as your strategy, the heart as your vision, the feet as your operating model and forgive the metaphor the gut as your source of fuel. Its where your resources churn and create the energy that makes everything else possible.

In other words, its your people.

Are your head, heart, feet and gut in harmony? Or, more likely, is your gut a little upset? Off balance? Irritated?

Think about how difficult it is to get anything done when your actual, physical gut is irritated. A large organization is the same. You can have a bold vision, a smart strategy, an effective operating model. But if your people are feeling stifled, not activated to their fullest potential, or bogged down by physical, emotional or financial health issues, none of that other stuff will make a difference.

In my last article, part 7 of this series, we heard from healthcare leaders. But the reality is were all in the business of health. No matter your industry, the physical, mental and financial health of your employees and their families affects your bottom line and your ability to thrive as an organization. The health of your customers and the communities you serve also affect the scope of the impact you can have.

How does this fit into this series of articles on our societys transition from an age of standardization to our current age of personalization? Heres a story that might help connect the dots.

A few years ago I met with some C-level executives at a company. I made a bold prediction: You probably have someone at the executive level who has a chronic disease or cares for someone with a chronic disease that is not covered by your insurance. They're probably struggling to get by, even with an executive salary."

Most respectfully disagreed with my prediction. But one person at the table scribbled a note and the CEO said: "Looks like I'm wrong." There was a VP who was living out of his car because he was paying for his mother's cancer and a grandparents diabetes.

If were leading in a way that honors this age of personalization, everything about that scenario should change. Ill leave it to the experts to fix our system so caring for sick family members wont cost so much. But we can at least we can create workplace cultures that dont make someone feel like they must hide such hardships from their peers.

We need systems in place for getting to know people as individuals. People shouldnt be afraid to discuss health issues related to physical or mental health. If they are afraid, youve got a problem.

In its Mental Health at Work 2019 Report, Mind Share Partners shares results from surveying 1,500 people in the United States: nearly 60% of respondentsreported symptoms of a mental health condition in the past year; and almost 60% of people never talked to anyone at work about their mental health in the last year. No wonder: when conversations about mental health did occur, less than half were described as a positive experience. One result? Youll lose good people. According to the survey, 50% of millennials, 75% of Gen Z-ers and 34% overall had left roles for mental health reasons, both voluntarily and involuntarily.

How do we as leaders open ourselves up so that people will be comfortable to be in their most vulnerable state?

This subject was tackled at the Leadership in the Age of Personalization Summit, where senior leaders from industries spanning healthcare, automotive, finance, consumer packaged goods, retail, technology, apparel and more, gathered to explore the tension were all feeling in this shift from standardization to personalization.

Throughout the day we discussed building economies of scale around human dignity, how to escape the extremes to achieve balance, how assimilation destroys individuality and inclusion restores it, how to allow personalized values to influence your brand identity, Wall Streets perspective on how companies are not prepared for what is about to hit them, how a companys mission is worthless without individual contribution and the importance of what you measure.

Tending to Employees Mental Health

Stephanie Neuvirth is the Senior Vice President of People and Organization at Banfield Pet Hospital.

She said Banfields people strategy is its business strategy, because to keep growing as a company they need to attract and retain more healthcare professionals a goal made more challenging by the cost of veterinary school and high levels of compassion fatigue among practitioners.

The pet space is growing at double digit growth, she said. As we look at the growth of our business and the trajectory over the next 10 years, and then look at the supply of the individuals in our space, candidly, the biggest concern to our growth strategy is our ability to find and keep great talent.

Stephanie Neuvirth and Gyasi Chisley during their panel discussion at the Leadership in the Age of ... [+] Personalization Executive Summit.

Banfield leaders believe theres a connection between Banfields commitment to preventive health for pets and its commitment to the health and energy of employees (whom they call associates). They deal with many of the same challenges as people in human healthcare do.

We see very high levels of compassion fatigue, high levels of suicide, high levels of burnout, said Neuvirth. What we see is a very serious and concerning situation about the profile of the individuals that go into our profession. They tend to be perfectionists. They are burdened with tremendous student debt. All of these things combined make it a very, very challenging environment.

Banfields health & wellbeing approach encompasses five areas: body, mind, finances, career and community.

We believe that all five parts are very important, and it's a different combination for every single person, said Neuvirth. For some, their biggest stressor is financial. For others its about not feeling connected to community. For others, it really is about not getting the career growth that they're looking for. So we're focused on how we bring all five parts to life and how to solve for the various combinations.

Ive written in the past about Banfields Veterinary Student Debt Relief Program (read about it here): Managing Employee Stress, Debt, and Emotional Turmoil in the Age of Personalization.

The nations largest general veterinary practice is also putting particular attention and resources behind mental health, addressing the suicide epidemic head-on.

According to the CDC, one in six veterinarians has considered suicide, said Neuvirth. Those are staggering and very concerning numbers. In 2018, we hired a mental health professional and are looking at partnering with social workers, not just for our client experience but for our associates.

She said they recently rolled out a first-of-its kind suicide prevention training for veterinary professionals called ASK Assess, Support, Know.

ASK is intended not only to support our own associates, but also to give them tools to spot emotional distress and suicidal thoughts in their colleagues, she said. In addition to making the ASK e-learning available to all 19,000+ Banfield associates nationwide, we also closed schedules at all of our 1,000+ Banfield hospitals for two hours to offer an interactive mental health and wellbeing training.

And theyre sharing the ASK training and resources with the industry.

As one of the largest employers in the veterinary health space, we feel a responsibility to support the entire profession, said Neuvirth. In observance of the harrowing 1-in-6 statistic, we made ASK available to the entire profession, including U.S. vet schools, on January 6, 2020.

That last part is so important: finding creative solutions and then sharing them with others.

In past articles Ive talked about discovering what you solve for as an individual what you solve for is what you consistently think about in a big way, the problems you are typically drawn to, and the kinds of solutions you favor. But it also applies to organizations.

One of the things Banfield is solving for is suicide awareness and prevention among healthcare professionals, and theyve created a method that can be used by others facing similar challenges. This is what can happen when you start tending to your gut and put individuals at the center of your strategy.

Making Cancer Care More Precise

Going back to healthcare in particular, one of our biggest challenges is to make sure our increasing levels of personalized care are accessible to all people. Next Ill share the personalization of cancer care from the viewpoint of a physician providing the care and then an executive of an organization expanding access to care.

Dr. Joseph Alvarnas is Vice President of Government Affairs, Senior Medical Director for Employer Strategy, and Associate Clinical Professor in the Department of Hematology/Hematopoietic Cell Transplantation at City of Hope.

He described how this tension between personalization and standardization has actually changed paradigms of care.

I'm a cancer care provider, he said. We've entered an era of precision medicine. So, things that we would have thought about as one cancer a decade ago when you look at them very closely on a genetic level, you realize they represent hundreds of different of sub-types of cancer.

He said there are about 22,300 genes in the human genome.

That's the entire instruction set to make, maintain, sustain a human being over the course of our lives, he said. Sometimes those genes go wrong in very, very particular ways. We're learning about these things at a pace that I would never have imagined years ago, and we're seeing innovations directed at very specific genetic mutations in cancer.

Dr. Alvarnas speaks at the Leadership in the Age of Personalization Executive Summit.

This idea that we can understand the genetic nature of someone's cancer, identify the exact correct therapeutic, and bring it to that individual in a timely, efficient, rapid way, said Dr. Alvarnas, so that we don't give wrong care, we mitigate unnecessary toxicities, we get that person well, keep them home, get them back to life that's actually real. That's the precision and personalized medicine paradigm for delivering care.

Talk about personalization. But he also posed this challenge: How do you create a system of high through-put knowledge understanding, and then marshal it to the needs of a patient in a family in a highly personalized way?

Because cancer care is not a technological experience, it's a human experience, said Dr. Alvarnas. We don't treat diseases. We care for patients and their families, because families are as responsible for good outcomes as any of the most critical elements of what we do.

Then he made the connection to employers.

Employers are invested in this, because not only do employers bear the costs for misadventures in care, but they also bear witness to the human consequences of what it's like to have an employee or a family member, or someone who's aligned with your company, go through a cancer journey.

Making Cancer Care More Accessible

Just as each cancer is different, so is each persons cancer journey.

Gyasi Chisley is another healthcare executive working hard to make those journeys as personalized as possible. He is President of Hospitals and Clinics for Cancer Treatment Centers of America (CTCA), a national comprehensive cancer care network with five hospitals around the country and a growing footprint of Outpatient Care Centers and other locations.

CTCA has been around for about 32 years, and its founder Richard J. Stephenson had the notion of creating a patient empowerment platform. Chisley said 82% of their patients live below the Federal Poverty Line. He said consumers come directly to them, usually for a second opinion, which means theyre often out-of-network.

A lot of the folks that were suffering from cancer or had that evil diagnosis were, number one, scared, and then number two, didn't have an opportunity to get that second opinion, said Chisley. So we started expanding through a footprint of what we call OIS, which is Oncology Information Systems just to get information out there directly to the patient. And that's been happening for 32 years.

They also took a holistic approach.

Our chairman had the foresight to say let's treat the patient holistically, with things like massage and acupuncture almost regardless of cost because we think thats better in the long run, said Chisley. But even more, what are the patient's goals? What are they really trying to achieve?

Chisley said one of the things theyre working on is going direct to employer, and having those crucial conversations with employers that will help them look at their workforce planning and look for opportunities for interventions that will ensure that the continuum of care is top of mind.

Glenn Llopis and Gyasi Chisley during their fireside chat at the Age of Personalization Executive ... [+] Summit.

We're not the most popular people in the payer's eyes these days we're doing things like having diet consults, we're doing things that are out of the box, if you will, for new cutting-edge clinical trials, and not always getting reimbursed from the payer, said Chisley. But you know what that is demonstrating? It's demonstrating to the employer that we're taking care of their people, and that's why we're going direct to employer and direct to consumer. So, that's opportunity for us, not only to be evolutionary, but revolutionary.

Chisley said after a day of hearing executives talk about personalization at the summit, hes inspired to dig even deeper as a leader: We see our patients come in at their most vulnerable times, particularly with this despicable disease of cancer. I've been vulnerable, but I haven't been vulnerable enough. And that's opportunity for me to be humble and make sure we're meeting our patients where they are.

An Appeal From Gen Z

Meeting people where they are. Thats what this age of personalization is all about.

After a full day of C-level leaders sharing their experiences and being vulnerable with each other, we closed the summit with a different kind of VIP your current customer, your future employee and, frankly, your future leader.

Brielle Lubin is in 8th grade. She describes herself as born from a Jewish-American father and a Japanese mother from Tokyo. She is very proud of her Jewish-American culture and is equally proud of her Japanese culture. At her school in Los Angeles she leads two clubs: the Gender Sexuality Awareness Club and the Asian American Cultural Club.

Throughout the day of the summit, she had been playing piano in the background. When she addressed the audience from the stage at the end of the day, she did it with the confidence of someone who already gives thought and action to these ideas of personalization.

Heres just a sampling of what she shared with us:

As a part of the youth community, we're always told, You have no idea what you're talking about. That's so ridiculous. That's frivolous. You're too young.

I may not be the CEO of a company like everyone else here. I'm just some 14-year-old kid. But you know what? When we're told when we're younger, Hey, you can be yourself, you can express your opinion, there are places where people can talk to you and help you I find that to be the most important thing. Because we cannot start assimilating when were young, if [our goal is to] avoid assimilating when we're older.

Brielle Lubin speaks at the Leadership in the Age of Personalization Executive Summit.

Everyone is a different shade of a color in the entire color spectrum. None of us is exactly the same. There's always some sort of shade that's just a little bit off, and that's the most important thing and we need to acknowledge that because identity crisis occurs the most when we don't recognize that difference, when we think we need to blend with other colors.

When people try to paint something, they don't just blend every single color of the rainbow together. They use all the colors individually, use them as a different shade on a different part of the paper, and that's what we are. We are all that different shade of a color on that paper.

Welcome to the Age of Personalization

Consider what Brielle said. This is the thinking thats already entering your workforce today, and will be in full force within your organizations in the next 10 years.

If youre not already trying to create the systems that allow for this level of inclusive leadership, you will not remain relevant in a marketplace where consumers and employees value their individuality.

The luxury of time is over, and I want to leave you with this sense of urgency. Throughout this series we have explored the difference between leadership in the age of standardization and in the age of personalization. But this is just the beginning.

Knowing something is right isnt enough to start doing it. And knowing something is wrong isnt enough to stop doing it.

We are a nation burning out at work not just because were working so hard and so much, but because were doing that without any sense of who we are and any connection to what we are doing. Engaged or not, the negative forces of standardization have stripped so many of us of our identities.

Only by rediscovering who we are as individuals and embracing that individuality in others can we find our purpose and contribute to a healthier whole.

Leadership in the age of personalization is about creating healthy environments we can all thrive in. It is the force that will push us to start over again. I see this as the beginning of a movement. And now the question is: what are you going to do about it?

Read more from the original source:
Leadership in the Age of Personalization is About Creating Healthy Environments So People Can Thrive - Forbes

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Scientists Discover 4 Distinct Patterns of Aging – Livescience.com

January 20th, 2020 5:49 am

Some people's hearts stay strong well into their 60s, but their kidneys begin to fail. Others may have the kidneys of a 30-year-old but fall victim to constant infection.

Now, scientists may be one step closer to understanding why the aging process varies so drastically between people.

Even within a single person, aging unfolds at different rates in different tissues, sometimes striking the liver before the heart or kidney, for example. People fall into distinct categories depending on which of their biological systems ages fastest, and someday, doctors could use this information to recommend specific lifestyle changes and design personalized medical treatments, according to a new study, published Jan. 13 in the journal Nature Medicine.

The research team behind the study sorted 43 people into aging categories, or "ageotypes," based on biological samples collected over the course of two years. The samples included blood, inflammatory substances, microbes, genetic material, proteins and by-products of metabolic processes. By tracking how the samples changed over time, the team identified about 600 so-called markers of aging values that predict the functional capacity of a tissue and essentially estimate its "biological age."

So far, the team has identified four distinct ageotypes: Immune, kidney, liver and metabolic. Some people fit squarely in one category, but others may meet the criteria for all four, depending on how their biological systems hold up with age.

"Now, it's going to be a lot more than just four categories," said senior author Michael Snyder, a professor and the chair of genetics at the Stanford University School of Medicine in California. For instance, one participant in the study appeared to be a cardiovascular ager, meaning their cardiac muscle accumulates wear-and-tear at a greater rate than other parts of their body. "If we [surveyed] 1,000 people, I'm sure we'll find other cardio agers and that category will become better defined." And with more research, even more patterns of aging may emerge, Snyder added.

Related: 8 Tips for Healthy Aging

In the past, scientists have hunted for markers of aging in enormous datasets for large populations, Snyder, told Live Science. Researchers pinpointed markers of aging by comparing data from young people to that of older people, but for individuals, that kind of data captures only a specific moment in time. It cannot reveal how a given person might change as they age, Snyder said.

In a clinical setting, that means population-based markers might not be the best measure to determine how a patient is aging, or what combination of medical treatments might suit them best, he added.

"Population-based decisions are crude at best," Synder said. They won't necessarily hold up for you, per se."

By tracking specific people through time, Snyder and his co-authors hoped to learn how aging markers differ between individuals. Their study participants ranged in age from 29 to 75 and provided at least five biological samples over the course of two years. Even within that relatively short time frame, several patterns of aging emerged.

For example, immunological agers accumulated more markers of inflammation through time, while metabolic agers accrued more sugar in their blood, indicating that their bodies were metabolizing glucose less efficiently. Similar to scores on a personality test, each individual's aging "profile" included a combination of traits, mixed and matched from different ageotypes.

Snyder and his co-authors plan to follow the study participants to see how their aging profiles morph over time. They also aim to develop a simple ageotype test that could be used in the doctor's office to quickly assess a patient's health status, and potentially point them toward the best possible treatment options.

"There are drugs and various kinds of dietary interventions and lifestyle interventions through which it may be possible to modulate some of these aging processes," Dr. James Kirkland, a gerontologist and head of the Kogod Center on Aging at the Mayo Clinic in Rochester, Minnesota, told NBC News.

"But in order to apply those correctly, we have to know which people to apply which drugs or which dietary interventions in order to get the most bang for the buck," said Kirkland, who was not involved in the new study.

Related: 7 Ways the Mind and Body Change With Age

While existing drugs, diets and exercise regimes can target some signs of aging, other markers aren't fully understood yet.

For example, over the course of Snyder's study, a marker of poor kidney function decreased in 12 individuals, eight of whom took statins. The marker, a waste product called creatinine, accumulates in the blood as muscle tissue naturally breaks down, but the kidneys typically filter the substance and expel it through the urine. Creatinine levels fell in the eight individuals on statins, suggesting that the medication improved their kidney function, though it's unclear why levels also dipped in four additional people, the authors noted.

The team also found that concentrations of several microbes seem to change with age, but we don't yet know how that may affect health. Certain microbes may proliferate in response to age-related changes in the body, while others help drive them, Snyder said. The authors also spotted differences in how diabetic and pre-diabetic people aged as compared to insulin-sensitive people, but it's unclear whether these markers indicate meaningful differences in health status. Many studies suggest that insulin plays a central role in aging throughout the animal kingdom, but more research is needed to clarify its exact influence over human aging.

For now, ageotypes present as many questions as they do answers about human aging. Until scientists understand what various aging markers really mean, clinicians will continue to rely on standard vital sign assessments to track patients' health over time. In the near future, perhaps ageotypes could serve to motivate people to take better care of areas of their body that appear to be aging faster than others, Snyder said. For instance, if someone fits the profile of a cardiovascular ager, they might focus on improving their cardiovascular health and undergoing relevant medical tests to check on their progress.

"As we collect a lot more information, we are going to be better able to follow how people are aging, [as well as] what interventions they did that actually reduced their aging," Snyder said.

Originally published on Live Science.

The rest is here:
Scientists Discover 4 Distinct Patterns of Aging - Livescience.com

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Artificial Intelligence Expert Neil Sahota Says AI Will Have Major Impact On 2020 Elections And In Medicine – Yahoo Finance

January 20th, 2020 5:49 am

Sahota Offers AI Predictions for the New Year

LOS ANGELES, Jan. 15, 2020 /PRNewswire/ --Artificial intelligence, or AI, will play a significant role in the 2020 election campaign and may also lead to major breakthroughs in solving personal medical issues, according to futurist and AI expert Neil Sahota.

"I'm increasingly concerned about the impact of fake news, photo scams and other deceits designed to negatively influence voting this year," says Sahota, who works closely with the United Nations and other organizations to foster innovation and develop next generation products/solutions to be powered by AI. "We will see the effect of more AI tools generating fraudulent information and influencing voters. Thankfully, there will also be new tools to fight this kind of disinformation. What is certain is that machine vs machine battles will become more prevalent."

The author of the influential book Own the AI Revolution (McGraw Hill), Sahota is also an IBM Master Inventor, who led the IBM Watson Group and is a professor at the University of California/Irvine.

In addition to its potential impact on the election campaigns, Sahota predicts AI will be responsible for significant medical advances. "We will see more use of AI that will accelerate solutions for doctors, nurses, clinicians and researchers in providing personalized care," he said. "Each of us is genetically unique and there isn't a one-size fits all solution for us. But AI can solve this dilemma by providing personalized medicine based on a specific person's genomic sequence, lifestyle, medical history, environment and other differences. I think there will be great strides in these areas in the coming year."

"The election and medicine are only two areas where we will feel the impact of AI, which is coming into its own as an emerging technology," Sahota says. "We are likely to see it help combine tools such as block chain, virtual reality and artificial reality. For example, I envision a virtual reality courtroom where a law student interacts with an AI 'judge,' opposing counsel and jury. AI simulation is not only more 'real world' but has great variability, meaning each time the VR module is used, it's different. There's no memorization or 'cheat sheet' for the law student. It's a dynamic, highly interactive learning module and 2020 will start the wave of convergence: combining these technologies together.

About Neil Sahota: Neil Sahota is a futurist and leading expert on Artificial Intelligence (AI) and other next generation technologies. He is the author of Own the AI Revolution (McGraw Hill) and works with the United Nations on the AI for Good initiative. Sahota is also an IBM Master Inventor, former leader of the IBM Watson Group and professor at the University of California/Irvine. His work spans multiple industries, including legal services, healthcare, life sciences, retail, travel, transportation, energy, utilities, automotive, telecommunications, media, and government.

View original content:http://www.prnewswire.com/news-releases/artificial-intelligence-expert-neil-sahota-says-ai-will-have-major-impact-on-2020-elections-and-in-medicine-300987177.html

SOURCE Neil Sahota

Originally posted here:
Artificial Intelligence Expert Neil Sahota Says AI Will Have Major Impact On 2020 Elections And In Medicine - Yahoo Finance

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