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Guava Health Benefits: Here’s Why Health Experts Are Talking About Vitamin C-Rich Amrud – NDTV News

January 29th, 2020 5:54 am

Guava benefits: One guava offers 200% of daily recommended intake of Vitamin C

Guava benefits: Guava, as nutritionist Rujuta Diwekar mentions, is a local fruit which is in season right now. Guava or amrud is a Vitamin C-rich fruit with lots of antioxidants, potassium and fibre. Eating guava every day can be beneficial for your blood sugar levels, heart health, digestive system and also weight loss. Lifestyle coach Luke Coutinho recently took to Instagram to talk about guava, mentioning how the fruit is great for boosting immunity and energy levels. So let's see why all health experts are talking about this seasonal fruit.

One of the most essential nutrients that guava contains is Vitamin C. It is the one nutrient that can boost your immunity enough to keep you healthy and disease-free. Nutritionist Nmami Agarwal says that one guava offers 200% of daily recommended intake of Vitamin C.

"Vitamin C is a powerful antioxidant that prevents from free radical damage and keeps the skin supple and glowing. It also contains lycopene, powerful antioxidant which has been scientifically proven protect against certain types of cancer," Nmami tells DoctorNDTV.

Vitamin C-rich guava can boost your immunity and help you be disease-freePhoto Credit: iStock

Also read:Nutritionist Recommended Foods For Quicker Healing, Stronger Immunity And Improved Overall Health

Guavas are naturally low in glycemic index. Thismakes them a perfect choice for diabetics, Nmami adds. "Guavas are also rich in fibre. Including them in your diet can improve digestive health and keep constipation at a bay," she says.

The best part about guava is that its not just the fruit which provides with health benefits, its leaves are equally beneficial. Nmami informs that guavas contain antibacterial and anti-inflammatory properties. "Guava leaves are also a perfect antidote for diarrhoea," she informs.

Also read:Inflammation: What Are The Risks Of High Inflammation In The Body?

As mentioned above, you can have guava as a mid-meal snack. You can eat the whole fruit without peeling the skin. "You can add guava to a smoothie or combine guava slices with cottage cheese cubes," recommends Nmami.

You can prepare guava chutney with guava leavesPhoto Credit: iStock

For consuming guava leaves, you can brew them in a tea or blend them to form a guava chutney.

This season, enjoy guavas without guilt. Make sure you eat at least one every day!

Also read:Turmeric Tea: Amazing Health Benefits You Cannot Afford To Miss; Learn How To Make Turmeric Tea

(Nmami Agarwal is nutritionist at Nmami Life)

(Rujuta Diwekar is a nutritionist based in Mumbai)

(Luke Coutinho, Holistic Lifestyle Coach - Integrative Medicine)

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.

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Newly minted professors of distinction to be celebrated – CU Boulder Today

January 29th, 2020 5:54 am

Four members of the University of Colorado Boulder facultyhave been named 2019Professors of Distinction by the College of Arts and Sciences in recognition of their exceptional service, teaching and research.

The new professors of distinction areNoel Clarkof physics,Stephen Graham Jonesof English,Robert Pasnauof philosophy, andKenneth P. Wright Jr.of integrative physiology.

This reveredtitleis reserved for scholars and artists of national and international acclaim whose college peers also recognize as exceptionally talented teachers and colleagues. Honorees of this award hold this title for the remainder of their careers in the College of Arts and Sciences at CU Boulder.

The four will be honored onMonday, Feb. 3,at 3:30 p.m. in the CASE Auditorium/Chancellors Hall. At the free and public event, Clark, Jones and Wright will give a public presentation based on his research or scholarly work. Pasnau is unable to attend the event this year but will give his presentation next year.

Wright, Pasnau, Clark, and Jones. (left to right).

Noel Clark, whose talk is titledSplashing Around in Soft Matter,received his PhD in Physics from MIT in 1970. He subsequently held the positions of research fellow and assistant professor of applied physics at Harvard, before moving to CU Boulder in 1977.

Research in Clark's group is directed toward understanding and using the properties of condensed phases, ranging from experiments on the fundamental physics of phase transitions, such as melting, to the development of liquid crystal electro-optic light valves.

His primary experimental tools are laser light scattering, electrooptics, video microscopy and high resolution synchrotron X-ray scattering. Much of the research is on the physics of liquid crystals, phases of matter having structure intermediate to that of liquids and solids, and on the physics of colloids, suspensions of one material in another that exhibit order on large length scales.

Stephen Graham Jones, whose Feb. 3 talk is titledBeing Indian is Not a Superpower,is the Ivena Baldwin Professor of English. He received his PhD in Creative Writing (Fiction) from Florida State University in 1998, and came to CU in 2008. At that time, he had five novels and one story collection published.

Since then he's published 11 more novels, five more story collections, and some novellas and comic books and chap books, and he's currently got north of 300 stories published. He has been an NEA recipient, has won the Texas Institute of Letters Award for Fiction, the Independent Publishers Award for Multicultural Fiction, a Bram Stoker Award, four This is Horror Awards, and hes been a finalist for the Shirley Jackson Award, the World Fantasy Award, the Wonderland Book Award, and the Colorado Book Award.

Hes also made Bloody Disgustings Top Ten Horror Novels, and will soon receive the Western Literature Association's Distinguished Achievement Award. At CU Boulder he's won the Carolyn Woodward Pope Prize for Faculty Publication, the Boulder Faculty Assembly Excellence in Research Award, and the Kayden Book Award, and he's a faculty affiliate with the Center for Native American and Indigenous Studies, the Center for the American West, and the Department of Ethnic Studies.

Aside from teaching fiction and screenwriting workshops, Jones teaches courses on comic books, the haunted house, the slasher, the zombie and the werewolf. His fiction navigates the spaces between the commercial and the literary, often using the tropes of horror and fantasy and science fiction and the western and noir in unconventional ways. He says he's not running out of stories anytime soon, either.

Kenneth P. Wright Jr., whose talk is titledSleep for Optimal Health and Performance,is a professor in the Department of Integrative Physiology and the director of the Sleep and Chronobiology Laboratory at CU-Boulder.

Wright received a BS in psychology from the University of Arizona (1990) and a PhD in Behavioral Neuroscience from Bowling Green State University (1996). Following postdoctoral training in the Division of Sleep Medicine at Harvard Medical School and Brigham and Womens Hospital, he served on the faculty at Harvard Medical School prior to joining the faculty at CU Boulder in 2002.

Wright has more than 25 years of experience in sleep and circadian research, has led individual and multicenter/transdisciplinary team projects, and has participated in multicenter clinical trials. His research aims to understand the physiology of sleep and circadian rhythms in humans and the health and safety consequences of sleep and circadian disruptionsuch as, metabolic dysregulation, impaired cognition, and compromised performance.

Wrights research also explores strategies to promote sleep, enhance alertness and maintain health and safety when sleep and circadian rhythms are challenged, as well as treatment strategies for patients with sleep and circadian related disorders.

He is a frequently invited speaker and media contact and has published more than 115 peer-reviewed articles. Wright manages a large undergraduate, graduate and postgraduate training program in sleep and circadian physiology at CU Boulder.

Wright has served in leadership, consulting, and advisory roles for government, professional, community, and commercial stakeholders, such as, the Sleep Disorders Research Advisory Board of the National Institutes of Health, National Heart, Lung, and Blood Institute, and the Board of Directors of the Sleep Research Society. He also serves as a reviewer for numerous national and international granting agencies and scientific journals.

Robert Pasnauhas taught in the Department of Philosophy since 1999. His research concentrates on the history of philosophy, particularly the end of the Middle Ages and the beginnings of the modern era.

He is the editor of theCambridge History of Medieval Philosophyand ofOxford Studies in Medieval Philosophy. His most recent book,After Certainty: A History of Our Epistemic Ideals and Illusions(OUP 2017), is based on his Isaiah Berlin Lectures, delivered at Oxford University in 2014.

Pasnau is the founding director of the Benson Center for the Study of Western Civilization.

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Healthcare Nanotechnology Nanomedicine Market : Outlook Continues to Remain Positive by 2015 2021 – The Trusted Chronicle

January 29th, 2020 5:52 am

Nanotechnology is one of the most promising technologies in 21st century. Nanotechnology is a term used when technological developments occur at 0.1 to 100 nm scale. Nano medicine is a branch of nanotechnology which involves medicine development at molecular scale for diagnosis, prevention, treatment of diseases and even regeneration of tissues and organs.

Thus it helps to preserve and improve human health. Nanomedicine offers an impressive solution for various life threatening diseases such as cancer, Parkinson, Alzheimer, diabetes, orthopedic problems, diseases related to blood, lungs, neurological, and cardiovascular system.

Development of a new nenomedicine takes several years which are based on various technologies such as dendrimers, micelles, nanocrystals, fullerenes, virosome nanoparticles, nanopores, liposomes, nanorods, nanoemulsions, quantum dots, and nanorobots.

In the field of diagnosis, nanotechnology based methods are more precise, reliable and require minimum amount of biological sample which avoid considerable reduction in consumption of reagents and disposables.

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Apart from diagnosis, nanotechnology is more widely used in drug delivery purpose due to nanoscale particles with larger surface to volume ratio than micro and macro size particle responsible for higher drug loading. Nano size products allow to enter into body cavities for diagnosis or treatment with minimum invasiveness and increased bioavailability. This will not only improve the efficacy of treatment and diagnosis, but also reduces the side effects of drugs in case of targeted therapy.

Globalnanomedicinemarket is majorly segmented on the basis of applications in medicines, targeted disease and geography. Applications segment includes drug delivery (carrier), drugs, biomaterials, active implant, in-vitro diagnostic, and in-vivo imaging. Global nanomedicine divided on the basis of targeted diseases or disorders in following segment: neurology, cardiovascular, oncology, anti-inflammatory, anti-infective and others.

Geographically, nanomedicine market is classified into North America, Europe, Asia Pacific, Latin America, and MEA. Considering nanomedicine market by application, drug delivery contribute higher followed by in-vitro diagnostics. Global nanomedicine market was dominated by oncology segment in 2012 due to ability of nanomedicine to cross body barriers and targeted to tumors specifically however cardiovascular nanomedicine market is fastest growing segment. Geographically, North America dominated the market in 2013 and is expected to maintain its position in the near future.

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Asia Pacific market is anticipated to grow at faster rate due to rapid increase in geriatric population and rising awareness regarding health care. Europe is expected to grow at faster rate than North America due to extensive product pipeline portfolio and constantly improving regulatory framework.

Major drivers for nanomedicine market include improved regulatory framework, increasing technological know-how and research funding, rising government support and continuous increase in the prevalence of chronic diseases such as obesity, diabetes, cancer, kidney disorder, and orthopedic diseases. Some other driving factors include rising number of geriatric population, awareness of nanomedicine application and presence of high unmet medical needs. Growing demand of nanomedicines from the end users is expected to drive the market in the forecast period.

However, market entry of new companies is expected to bridge the gap between supply and demand of nanomedicines. Above mentioned drivers currently outweigh the risk associated with nanomedicines such as toxicity and high cost. At present, cancer is one of the major targeted areas in which nanomedicines have made contribution. Doxil, Depocyt, Abraxane, Oncospar, and Neulasta are some of the examples of pharmaceuticals formulated using nanotechnology.

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Market Players

Key players in the global nanomedicine market include:

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Healthcare Nanotechnology Nanomedicine Market : Outlook Continues to Remain Positive by 2015 2021 - The Trusted Chronicle

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Shanghai Hospital to Develop mRNA Vaccine Targeting the 2019-nCoV in 40 Days – PrecisionVaccinations

January 29th, 2020 5:52 am

According to the Shanghai East Hospital of Tongji University, a Messenger RNA (mRNA) vaccine targeting the novel coronavirus (2019-nCoV) may become available in a few months.

The project has already completed an emergency filing.

Announced in a press release on January 28, 2020, the mRNA vaccine will be co-developed by the Shanghai East Hospital and Stermirna Therapeutics Co., Ltd.

Li Hangwen, the CEO of Stermirna Therapeutics, is reported by Xinhua to have said no more than 40 days will be needed to manufacture the vaccine samples based on the new generation of mRNA technology and some preliminary procedures.

Li Hangwen said this accelerated development process can be achieved since mRNA vaccines have shorter development and production cycles.

Separately, Li Hangwen, a project leader of the translational medicine platform of Dongfang Hospital and chairman of Sri Lanka Microbiology, said in a press release that using relevant platform technology, rapid synthesis of mRNAs with different antigen sequences targeting key targets of this new type of coronavirus, and through nano-lipid.

The translational medical platform of Dongfang Hospital affiliated to Tongji University cooperated with Siwei (Shanghai) Biotechnology Co., Ltd. and relied on the subject of "Shanghai Zhangjiang National Independent Innovation Demonstration Zone Stem Cell Strategic Library and Stem Cell Technology Clinical Translation Platform" Sub-task-the results of the mRNA synthesis platform, to quickly promote the development of new coronavirus mRNA vaccines.

This drug-loaded technology is used to prepare the preparation, and in vivo and animal experiments are used to screen and verify effective antigens.

The new generation of mRNA vaccine technology that has emerged in recent years has the advantages of short development and production cycles and can realize the timely production and application of vaccines.

Based on this, large-scale preventive 2019-nCoV vaccine sample production and preparation will be completed within 40 days.

After completing the necessary approval process, the mRNA vaccine candidate can be promoted to the clinic as soon as possible.

Preventive vaccines are the key to extinguishing the large-scale epidemic of major infectious diseases.

In view of the current epidemic of 2019-nCoV, the traditional vaccine has a problem that the production cycle is too long, said this press release. For example, the production cycle of the recombinant protein vaccine takes 5 to 6 months, which cannot meet the need to extinguish the epidemic in time.

Although several vaccine candidates are currently in clinical trials, many still remain in the pre-clinical stage.

Novel coronavirus vaccine news published by Precision Vaccinations.

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Antisense & RNAi Therapeutics Market By Technology, Route of Administration, Application and Region Global Industry Analysis, Market Share,…

January 29th, 2020 5:52 am

Global Antisense and RNAi Therapeutics Market was valued US$ X1.2X Bn in 2019 and is expected to reach US$ XX Bn by 2027, at CAGR of X7.XX% during forecast period of 2020 to 2027.

Global Antisense & RNAi Therapeutics Market

Global Antisense and RNAi Therapeutics Market: Overview

In past years, pharmaceutical companies were motivated about the prospective of RNA interference (RNAi). But later, financial volatility and subsequent suspensions by pharmaceutical companies have articulated that RNAi therapeutics market was fiished. Yet, advances in nano medicine helped the vast potential of RNAi therapeutics to flourish. Antisense technology offers the prospect to influence the gene expression and this is being considered as an effective treatment for various diseases. Based on this factor, great number of gene silencing drugs are in the development process.

The global antisense and RNAi therapeutics market have gathered substantial attention in the recent years, due to its perspective to treat many sort of chronic diseases such as tuberculosis, diabetes, cancer, AIDS, as well as certain cardiovascular problems. This prospect is being cashed on by the many companies in this industry and are investing in R&D. Just to emerge as being in the clinical research division, the RNA based therapeutics are likely to be explored as a most efficient treatment choice for the disorders, which are very difficult to treat. Market is expected to grow at CAGR XX.XX% over the forecast period, as number of companies are into the development of molecules focused on antisense technology.

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However, there are many challenges associated with the emerging antisense technology and RNAi. One of the noticeable issue is the drug delivery to the proposed portion. Drug delivery to the nervous tissues is one of the problems as the drug has to pass the blood-brain barrier. Major players in the industry are coming up with solutions to overcome these challenges.

The other challenge is toxic effects caused by the use of this technology. Determining the right dosage and path for drug delivery of an antisense molecule is one of the most crucial process to ensure the safe administration. While overcoming this as much as possible and implementing it, companies have encountered multiple rejections from the regulatory bodies. For instance, FDA has refused, an antisense molecule to treat familial chylomicronemia syndrome by the renowned U.S. organization Akceas Waylivra. Such events would push companies to develop better paths, efficient delivery solutions, and effective compositions.

Global Antisense and RNAi Therapeutics Market: Growth Factors

In RNAi therapeutics, more influential product focus vs. platform technologies and virtual drug expansion models that enable several companies to minimize the R&D costs, are expected to attract investors and supplement in the growth of the market. Instead, major issues in drug delivery as well as high failure rates are some of the biggest barriers for companies working in this particular field. Despite the limitations, the players in the pharmaceutical sector are interested and focused for the commercialization of these therapies, hence antisense and RNAi therapeutics market have chances to grow substantially with CAGR of XX.XX% and expected to reach US$ XX.XX Mn by the end of the forecast period.

Global Antisense and RNAi Therapeutics Market: Regional Analysis

North America has experienced to be the most lucrative market in the recent times and has contributed a substantial share in the Global Antisense and RNAi Therapeutics Market. Multiple clinical trials have shown favorable results and are even progressing through the development stages. Supposing such trials expected to show positive results, the North American market can be expected to witness the exponential growth during forecast period. Furthermore in the U.S. several biotechnology companies have made considerably high investments for RNAi therapeutic development and number of RNAi therapeutics are in final stage of development phases. In North America, clinical laboratories are likely to contribute significant revenue generation via platform and product licensing. Supportive government regulation and provision to increase the number of clinical trials therein encourages the method of initiation for exploring antisense therapeutics. The forthcoming commercialization of several players are under R&D will help to boost the global antisense and RNAi therapeutics market in North America in the forecast period.

The increasing government expenditure toward R&D, as well as different forms of siRNA delivery methods, is a strong side propelling the growth of the global antisense and RNAi therapeutics market in Asia Pacific region. Still this region is experiencing the moderate growth rate with CAGR of XX.XX% during 2014-2018, but post commercialization of these therapies, prospects, and forthcoming opportunities in the Asia Pacific are likely to be more profitable, presenting a maximum development rate with the consistently growing CAGR of XX.XX% in the forecast period from 2020 to 2027.

Antisense & RNAi Therapeutics Market Insights and developments

In the recent years there are many discoveries in the field of technologies with regards to Global Antisense & RNAi Therapeutics Market, which in turn will help the industry to grow. Big pharmaceutical developers have entered into collaboration agreements or outsourcing deals with a several of smaller firms & new entrants in an effort to take advantage of on the expected growth in revenue that this market can generate over the forecast period. For instance, Agreement between AstraZenecas and Ionis pharmaceuticals is one of the big deals that are hugely investing & doing R&D into antisense technology.

Since the discovery of RNAi in, there are various ways of treatment of multiple diseases using RNAi, still, the market has picked up very little over the past decade due to the complexities in delivery methodologies associated to RNAi. But due to initiatives by key players and ongoing R&D have shown the chances of better growth.

Rising need for the cure and prevention of diseases like cancer, AIDS and several diseases caused by mutating viruses is anticipated to impact the usage rate of oligonucleotide products. This field is rapidly expanding owing to the increasing number of clinical trials for the oligonucleotide drugs. For instance, Ionis Pharmaceuticals has 2 approved molecules in the European Union and 1 in U.S. along with 4 molecules in pipeline.

Many key players are putting efforts in developing novel delivery systems like nanocarriers, to encourage the in-vivo delivery of the oligonucleotides. To develop the bioavailability, carrying capability of siRNA payload and they deliver high interface with the target cells are the key functions of Nanocarriers, for which they are recognized mostly. The development of newer nanotechnology-oriented methods has offered high potential to the market to grow during the forecast period. Nanocarriers can reduce the toxicity of these oligonucleotides. There is huge need for the latest and harmless delivery systems for cancer and other viral diseases, which is expected to suppliment the market growth. Significant pipeline for cancer therapies by organizations and institutes such as, Enzon Pharmaceuticals (Santaris Pharma), OncoGenex, University of Texas, Astrazeneca (Ionis Pharmaceuticals), Isarna Therapeutics and INSYS Therapeutics, Inc. have huge contribution in driving the market.

Detailed analysis of competition, new entrants, strategic alliances, mergers and acquisition in the Global Antisense & RNAi Therapeutics Market is covered in the report. The report covers the market leaders and followers in the industry with the market dynamics by region. It will also help to understand the position of each player in the market by region, by segment.

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Global Antisense & RNAi Therapeutics Market Company Profiles

The players operating in the Global Antisense & RNAi Therapeutics Market, analyzed in the report are:

GSK, Sanofi-Genzyme, Alnylam Pharmaceuticals, Marina Biosciences, Benitec Biopharma, Alnylam Pharmaceuticals, Ionis Pharmaceuticals, Akcea Therapeutics, Quark Pharmaceuticals, Gene Signal

Global Antisense and RNAi Therapeutics Market: Segmentation

The global antisense and RNAi therapeutics market is classified into technology, application, and route of administration. In terms of technology, the global antisense and RNAi therapeutics market is bifurcated into RNA interference and antisense RNA. The segment RNA interference is further sub-divided into miRNA and siRNA. In terms of application, the global antisense and RNAi therapeutics market are categorized into cardiovascular, oncology, renal diseases, respiratory disorder, genetic disorders, a neurodegenerative disorder, infectious diseases, and others. In terms of route of administration, the global antisense and RNAi therapeutics market is sub segmented into intravenous injections, pulmonary delivery, intraperitoneal injections, intradermal Injections, topical delivery, and other delivery methods.Global Antisense and RNAi Therapeutics Market by Technology

RNA Interferenceo siRNAo miRNA Antisense RNAGlobal Antisense and RNAi Therapeutics Market by Application

Oncology Cardiovascular Diseases (CVDs) Respiratory Disorders Renal Diseases Neurodegenerative Disorders Genetic Disorders Infectious Diseases OtherGlobal Antisense and RNAi Therapeutics Market by Route of Administration

Pulmonary Delivery Intravenous Injections Intra-dermal Injections Intraperitoneal Injections Topical Delivery Other Delivery Methods

MAJOR TOC OF THE REPORT

Chapter One: Antisense & RNAi Therapeutics Market Overview

Chapter Two: Manufacturers Profiles

Chapter Three: Global Antisense & RNAi Therapeutics Market Competition, by Players

Chapter Four: Global Antisense & RNAi Therapeutics Market Size by Regions

Chapter Five: North America Antisense & RNAi Therapeutics Revenue by Countries

Chapter Six: Europe Antisense & RNAi Therapeutics Revenue by Countries

Chapter Seven: Asia-Pacific Antisense & RNAi Therapeutics Revenue by Countries

Chapter Eight: South America Antisense & RNAi Therapeutics Revenue by Countries

Chapter Nine: Middle East and Africa Revenue Antisense & RNAi Therapeutics by Countries

Chapter Ten: Global Antisense & RNAi Therapeutics Market Segment by Type

Chapter Eleven: Global Antisense & RNAi Therapeutics Market Segment by Application

Chapter Twelve: Global Antisense & RNAi Therapeutics Market Size Forecast (2019-2026)

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Cape Breton University researchers hope to help water woes – TheChronicleHerald.ca

January 29th, 2020 5:52 am

SYDNEY, N.S.

Work taking place at Cape Breton University could help small communities both locally and globally deal with water contamination issues.

Shine (Xu) Zhang is a CBU chemistry professor and holds the Tier II Canada Research Chair in healthy environments and communities and the industrial research chair in applied nanotechnology. He is working on a project that involves electrochemical water treatment which he believes can offer a green, efficient and cost-effective alternative.

Water pollution, water contamination is a global concern but its also a local problem for Cape Breton and Nova Scotia, Zhang said.

He said he wanted to take on water contamination as a research topic because it is such a big issue.

CBU is a local university, but CBU really wants to contribute to the community, Zhang said. The environment is a big issue. Water contamination is also a global issue, therefore, research here, if we do a good job, can not only help local communities but also help people far away from here.

We want to apply what we learn to solve some real-world problems.

His research program aims at exploiting nanotechnology and nanomaterials for environmental and health applications with a focus on water treatment, cancer diagnostics and treatment with precision nanomedicine. Zhang has published 65 journal articles.

He describes the technology hes developed as being relatively simple, with an electrode acting like a filter. One electrode removed organic material while another electrode removed heavy metals.

Water comes through the filter, dirty water becomes clean, Zhang said.

The technology, I feel is useful because, from a research standpoint, energy consumption is very low, so essentially its quite cost-effective. That is compatible, for example, with solar panel, those kinds of various sustainable power source. It can be a very automatic system, so you dont need a lot of manpower to run it.

A request for proposals for a market research consultant issued by CBU recently closed and Zhangs team is currently reviewing the proposals received. It asked for proposals to outline how the consultant would go about understanding and marketing the technology, from lab to market through the successful negotiation of a licence.

Zhang said they are now evaluating the best way to commercialize the technology.

Were looking for different industry partners so that we can do further development of specific products or applications for this to meet different needs, he said. For example, we work with environmental remediation companies, we work with landfill leachate, we work on pharmaceutical wastewater. We want to find industry partners to work on further development.

Its hoped the consultant that they hire will assist in finding those partners. A prototype has been developed.

The ideal starting industry level would be 3,000 litres a day, were about halfway there already, were at about 1,500 litres a day," said Andrew Carrier, who works closely with Zhang.

Carrier noted the technology also works in flows, so you dont need a large quantity of contaminated water to make use of it, and it doesnt take up much physical space. They want the technology to be accessible to as many people who can make use of it as possible, he added.

Its easy to put into a remote location without having to invest much capital, Carrier said.

Zhang noted the technology also doesnt generate any sort of secondary waste as a result of its water treatment.

Zhangs work has been supported by the Atlantic Canada Opportunities Agency, Innovacorp, Springboard Innovation Mobilization program, Nova Scotia Lands as well as CBU.

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Kannalife, Inc. CEO Recaps 2019 Advances and Potential Ahead – Yahoo Finance

January 29th, 2020 5:51 am

DOYLESTOWN, Pa., Jan. 28, 2020 (GLOBE NEWSWIRE) -- Kannalife, Inc. (Kannalife or the Company) (KLFE), a biopharmaceutical company specializing in the research and development of cannabinoid therapeutics, announced today that it has issued a letter to its shareholders providing commentary on the Companys recent initiatives and corporate updates.

The Companys Chief Executive Officer, Dean Petkanas, commented: 2019 was a milestone year for Kannalife. Its nice to see dedicated shareholders, management, employees and trusted partners and collaborators bring a small enterprising 10-year-old startup company to the cusp of expansion and commercialization efforts in 2020. With limited resources over the past decade, we have been truly blessed as we have built an impressive track record in the cannabinoid therapeutics space. We can now share the potential of our science with investors as a publicly traded company. We hope our existing and future shareholders will join us in our excitement as Kannalife continues to execute on innovative new technologies in the biotech and pharmaceutical arena.

Highlights of the letter include:

To read the Letter to Shareholders in full, please visit: https://www.kannalife.com/wp-content/uploads/2020/01/Kannalife-Inc.-Shareholder-Letter-200128.pdf.

About KLS-13019KLS-13019 is Kannalifes leading proprietary investigational CBD-like product for the potential treatment of a range of neurodegenerative and neuropathic pain disorders, beginning with chemotherapy-induced peripheral neuropathy (CIPN). KLS-13019 has not been reviewed or approved for patient use by the U.S. Food and Drug Administration (FDA) or any other healthcare authority in the world. Its safety and efficacy have not been confirmed by FDA-approved research.

About Kannalife, Inc.Kannalife, Inc. is a biopharmaceutical company focused on the development of proprietary and patented cannabidiol (CBD) and CBD-like molecules for patients suffering from unmet medical needs of neurodegenerative disorders - including chemotherapy-induced peripheral neuropathy (CIPN), a chronic neuropathy caused by toxic chemotherapeutic agents; hepatic encephalopathy (HE), a neurotoxic brain-liver disorder caused by excessive concentrations of ammonia and ethanol in the brain; mild traumatic brain injury (mTBI), a disorder associated with single and repetitive impact injuries; and chronic traumatic encephalopathy (CTE) a disease associated with highly repetitive impact injuries in professional and amateur sports.

The Company's family of proprietary molecules focuses on treating oxidative stress-related diseases such as HE, chronic pain from neuropathies like CIPN, and neurodegenerative diseases like CTE. Kannalife conducts its research and development efforts at the Pennsylvania Biotechnology Center of Bucks County in Doylestown, PA.

For more information about Kannalife, Inc., visit http://www.kannalife.com and visit the Companys Twitter page at @Kannalife.

Forward-Looking StatementsThis press release may contain certain forward-looking statements and information, as defined within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and is subject to the Safe Harbor created by those sections. This press release contains statements about expected future events, the companys business plan, plan of operations, the viability of the companys drug candidates, and/or financial results that are forward-looking in nature and subject to risks and uncertainties. Such forward-looking statements, by definition, involve risks and uncertainties. The company does not sell or distribute any products that are in violation of the United States Controlled Substances Act.

CONTACT:

Public Relations:

Andrew Hard, Chief Executive Officer of CMW MediaP: 888-829-0070E: andrew.hard@cmwmedia.com

Mike Mulvihill, Senior Counsel, PadillaP: 804-334-2292E: mike.mulvihill@padillaco.com

Investor Relations: Scott Gordon, Managing Director of CORE IRP: 516-222-2560E: scottg@coreir.comwww.coreir.com

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Health News 2 Use: Customized therapy helps patients recover – kjrh.com

January 29th, 2020 5:51 am

TULSA, Okla. Cancer treatment is more than surgery, radiation and chemotherapy.

Physical and occupational therapy are also important tools in a patient's fight for a normal life.

Merideth Metz used customized therapy to recover from the side effects that can occur with treatment.

When a doctor told Metz to give up after her colon cancer diagnosis, she left and went to Cancer Treatment Centers of America in Tulsa about a year and a half ago.

"No active cancer as of last September, confirmed in October, and now, I'm here for my first three month check," Metz said.

Once her chemotherapy was done, she needed physical therapy, speech therapy and occupational therapy to help with neuropathy that's common after chemo.

"Our job is to focus on the patient's wants," said Barry Calvert, an occupational therapist with CTCA. "Trying to help them stay actively participating in those as best they can throughout the course of their treatment."

Calvert came up with a creative option, like art to document her journey towards healing.

Now, Metz is looking forward to her next effort in the new year.

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Health News 2 Use: Customized therapy helps patients recover - kjrh.com

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Veteran who died after Montrose-area fire remembered as witty, kind – MLive.com

January 29th, 2020 5:51 am

MONTROSE TWP, MI The 83-year-old man who died following a fire at a Montrose Township home is being remembered by family as kind.

Firefighters were called out around 6:50 p.m. Jan. 24, to a blaze at the Riverside Mobile Home Park located at the corner of Virginia and Joan drives.

A man inside the home died in the fire. He has been identified by family as Ellis Paul Kuykendall, 83.

Man found dead at scene of Montrose mobile home fire

Lisette McKiernan, Kuykendalls granddaughter, said he was originally from Tennessee but grew up in Las Vegas.

McKiernan took care of Kuykendall for the last decade prior to him moving in with her son Matthew Price several months ago.

Theyd lived in the mobile home park for approximately three weeks before the fire.

Kuykendall was a U.S. Air Force veteran, serving two years of active duty.

He was just a very witty man, said McKiernan. He had a good sense of humor. He was just a very kind individual."

Kuykendall enjoyed playing word searches and rummy. McKiernan kidded that his nurses had to learn the game in order to get in some games.

Hed been diagnosed with neuropathy in his legs that left him wheelchair-bound, McKiernan said.

No other injuries took place in the fire, but McKiernan said her son and two grandchildren -- a 4-year-old boy and a 6-year-old girl -- lost their home.

Were just pretty much devastated right now, she said.

Community members have reached out to Price with donations.

Thank you to the community for reaching out and all their support, said McKiernan. Matthew appreciates everything the community has provided for them.

A GoFundMe page has been set up to help the family transport Kuykendall back to Las Vegas and help Price get back on his feet.

The cause of the fire remains under investigation.

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Gene therapy zeroes in as LHON treatment – Ophthalmology Times

January 29th, 2020 5:51 am

Abstract / Synopsis:

Gene therapy for Leber's hereditary optic neuropathy appears highly promising for increasing the best-corrected visual acuity in this patient population.

This article was reviewed by Jiajia Yuan, PhD

Gene therapy for Lebers hereditary optic neuropathy (LHON) seems to be the first promising treatment for the disease.

LHON, a maternally inherited disease, causes optic nerve atrophy that in most cases results in simultaneous or sequential bilateral visual loss. Disease onset typically happens in patients between 14 to 21 years of age.

The most frequently occurring offending mutation is ND4 that appears in about 90% of Chinese patients and in about 50% to 60% of U.S. patients, according to Jiajia Yuan, PhD, Tongjl Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

No treatment is currently available for this disease.

Related:Gene therapy offering hope for retinal, corneal patients

LHON treatmentDr. Yuan and colleagues initially treated nine patients with LHON with gene therapy in 2011. With this first attempt, she reported seven of the nine patients had a significant improvement of 0.3 logarithm of the minimum angle of resolution (logMAR) VA at 36 months in the best-corrected visual acuity (BCVA).

We saw a durable response in six of these patients out to 75 to 90 months after treatment, she said. In addition, a bilateral improvement was achieved, as also was observed by other groups investigating gene therapy.

Gene therapy trialThese promising results prompted a second multicenter gene therapy trial that began in 2017 that include 149 Chinese patients and 10 Argentinian patients.

According to Dr. Yuan, the patients, who ranged in age from 7 to 45 years, received a fixed dose of 1 x 1010 mg/eye for all patients, regardless of age, Dr. Yuan explained.

Related: Research targets precision data for gene, cell therapy

Promising resultsThe treatment was found to be well tolerated and no severe adverse effects occurred, she said.

Keratitis developed in one eye at one month and anterior inflammation in one eye at three months that were both considered to be unrelated to the treatment.

Ocular hypertension was the most common adverse event that developed in 27.04% of eyes that decreased slowly over time after cessation of the steroid.

A significant improvement in the BCVA occurred in 63.21% (67 of 106 patients) at 12 months. The rest of the patients had not reached the 12-month time point at the time of this report. Similar to the initial study, the patients showed bilateral improvement.

This is a real-world study, in that there was no specific patient selection, Dr. Yuan explained. The patients ages spanned a wide range as did the time of disease onset and the pretreatment BCVA.

An evaluation of only the Argentinian patients showed that all had improvement in the BCVA.

These patients fared better overall than the other patients in the group, with the average improvement in the treated eye was 0.6 logMAR and the average improvement in the untreated eye was 0.9 logMAR, Dr. Yuan pointed out.

Related: Gene therapy for LHON: Deciphering phase III data

Importantly, this improvement in the BCVA is highly relevant for the ability of patients to function well during everyday tasks.

And the researchers saw results with the patients that were treated.

Dr. Yuan related that three months after treatment, a patient was able to cook and watch sporting events on the computer.

Dr. Yuan noted that gene therapy is a promising approach for patients with LHON.

Nine patients were treated in 2011 to 2012 and we continue to follow them, she concluded. This is the longest term data from human gene therapy to date.

Related: Gene therapy focus of Schepens lectures at AAO 2019

ConclusionsAccording to Dr. Yuan, nearly two-third of 106 patients who reached the 12-month follow-up point achieved a clinically significant improvement in the BCVA.

Importantly, no serious adverse events occurred in the real-world studies, she said. We are very excited about the potential impact of gene therapy on this disease.

Read more by Lynda Charters

Jiajia Yuan, PhDE: [emailprotected]This article is based on Dr. Yuan's presentation at the American Academy of Ophthalmology's 2019 annual meeting. Dr. Yuan has no financial interest in any aspect of this report.

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Medical Foods Market Scope, Segmented By Company, Application and Region, Forecast To 2025 – Science of Change

January 29th, 2020 5:51 am

Global Medical Foods Market: Overview

One of the key factors boosting the growth of the global medical foods market is the rising awareness among the people regarding medical foods. The rising focus of the regulatory bodies on the manufacturing and labelling of medical foods will also be a key factor fuelling the growth of the medical foods market. In addition to this, the high focus by manufacturers on developing disease-specific formulas effective patients nutrition or diet care are also anticipated to result in the growth of the global medical foods market.

The report also enlists various factors which are anticipated to pose a challenge for the growth of the market. The current trends in the market and those that are anticipated to shape the future of the market have been discussed in detail in the report.

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By product, the medical food market is segmented into powder, pill, and others. Of these the powder segment has held a key share in the market as many medical food products are manufactured in powdered form and consumed in a semi solid or liquid form. By application, the global medical foods market is segmented into depression, diabetic neuropathy, ADHD, Alzheimers disease, and nutritional deficiency. Of these, diabetic neuropathy has been accounting for key shares within the market. The risk of neuropathy is boosted with age, diet changes, and unhealthy lifestyle.

In the years to come, it is anticipated that the nutritional deficiencies segment will develop a strong CAGR, as patients being treated for ADHD, autoimmune diseases, and cancer are likely to have high nutritional requirements, which is subsequently anticipated to boost the demand for medical foods.

Global Medical Foods Market: Snapshot

The global medical foods market has become increasingly important in the healthcare sector in recent years due to the rising awareness about its importance in complementing the treatment. Medical food comprises diets designed specifically to overcome the nutritional deficiencies caused by some diseases or to fulfill the specific dietary needs in the management of some diseases. The global medical foods market is likely to receive steady support from the healthcare sector in the coming years due to the rising prevalence of diseases such as Alzheimers among the elderly and ADHD among children, as these diseases are among the prime diseases that necessitate specific diet plans.

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Global Medical Foods Market: Key Trends

The rising geriatric population is a major driver for the global medical foods market. Old people are more likely to develop nutritional disorders as well as to fall prey to other diseases that affect their ability to absorb nutrients from their diet. Nutrition deficiency disorders are also more common among the geriatric demographic than in other patient classes, leading to the geriatric population becoming a key consumer segment for the global medical foods market.

The increasing prevalence of diabetes across the world is another key driver for the global medical foods market. Diabetic neuropathy is the leading application of the global medical foods market and is likely to retain dominance in the coming years. Diabetic neuropathy is becoming common among diabetic patients due to their often unhealthy lifestyles, with close to three-quarters of all diabetes likely to also suffer from some form of neuropathy. This is a key driver for the global medical food market, as the rising prevalence of diabetes in emerging regions has, in conjunction with the rising investment in the healthcare sector, created a conducive environment for growth of the market.

The rising prevalence of ADHD among children is also likely to remain a key driver for the global medical foods market. The growing prevalence of the disease has led to intensive research into its causation and treatment. The role of nutrition in the management of psychological problems such as ADHD has thus come under the scanner. On the opposite end of the spectrum, the rising prevalence of neurodegenerative conditions among the geriatric population is also likely to remain a key driver for the global medical foods market in the coming years.

Global Medical Foods Market: Market Potential

The global medical foods market is likely to witness a steady shift towards pills and away from powders. While powders can be easily mixed with various types of food, many patients dont enjoy their taste. This has led to pills becoming a preferred mode of delivery for many, and are thus likely to rise in demand in the global medical foods market in the coming years.

Apart from leading diseases such as diabetic neuropathy and Alzheimers, other diseases such as phenylketonuria (PKU) are also likely to come under the ambit of the medical food market in the coming years. In April 2017, PKU Sphere, a new medical food for patients of PKU was launched. PKU Sphere is claimed to contain a balanced mix of amino acids and glycomacropeptide, a protein essential for patients of PKU, who cant digest phenylalanine and have to fulfill their protein requirements in alternate ways.

Global Medical Foods Market: Geographical Dynamics

North America is likely to remain the leading regional contributor to the global medical foods market in the coming years due to the ready availability of advanced healthcare technology and a solid database regarding the dietary needs of patients suffering from various diseases. The rising prevalence of diabetes in North America, due primarily to the unhealthy lifestyle practiced by citizens in developed countries such as the U.S., is also likely to be crucial for the medical foods market in North America in the coming years.

Global Medical Foods Market: Competitive Dynamics

The leading players in the global medical foods market include Abbott, Fresenius Kabi AG, Targeted Medical Pharma Inc., Danone, and Primus Pharmaceuticals Inc. The steady support to development of sophisticated disease-specific formulas is likely to benefit the medical foods market in the coming years.

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Medical Foods Market Scope, Segmented By Company, Application and Region, Forecast To 2025 - Science of Change

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WVU project works to prevent blindness in diabetic patients – WDTV

January 29th, 2020 5:50 am

MORGANTOWN, W.Va. (WDTV)-- A West Virginia practice-based program with the help of other officials at WVU work to help bring awareness for diabetics.

With the project, staff across the state train to find early detection for diabetic retinopathy.

"Vision loss, more loss of quality of life so we're really trying to get it as early as possible so we're really able to keep the patients functioning in their normal life styles as long as possible," Stacey Whanger said.

Patients can go see a doctor where a camera will take a picture of their eyes. Those images are sent over to the WVU eye institute.

"The retina ophthalmologist will grade based on the severity of the disease and any other pathology they might find then later sent back to the health care provider," Whanger said.

For diabetic patients, doctors recommend everyone gets an exam once a year, especially if patients have vision loss that can't be fixed with glasses.

"Then we can do some treatment to help that blindness. so it's really important to get the screening done we can then prevent the blindness is someone is having damage due to their diabetes," Treah Haggerty said.

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WVU project works to prevent blindness in diabetic patients - WDTV

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PFFB, Eye Donation Campaign striving against blindness – The News International

January 29th, 2020 5:50 am

PFFB, Eye Donation Campaign striving against blindness

Islamabad : Former federal secretary Abdullah Yousaf who is chairman of Pakistan Foundation Blindness said that since the aim of PFFB and Eye Donation Campaign is to restore eyesight of blind persons, both organisations have agreed to make joint efforts. He expressed their views during the meeting of the board of trustees of PFFB.

PFFB is the pioneer organization in Pakistan working for the relief of blind persons it is involved in research work in collaboration with retina international. The foundation is also carrying out different projects to help blind and disabled persons in the country. The meeting was attended by trustees and CEO of foundation Mrs. Nasrin Mansoor, Chief Co-ordinator Rabail Pirzada, Ex Fed Sec Information Syed Anwer Mehmood, Company sec Lubna Aftab.

Chairman Eye Donation Campaign Dr. Mazhar Qayyum briefed the members about objective and functioning of the campaign. He said that 3 Lac blind persons are on waiting list for corneal grafting operation. Corneas are obtained from the Eye of Dead Persons who has given consent during life time.

He said the campaign is to make people aware that they can help restore eyesight of so many peoples by signing the Consent Form. Dr. Mazhar Qayyum said that we all need to put together our efforts since to get 3 lac corneas as donation is a huge target. He said multiple social organisations should join hands to fulfil the great objective.

The members of PFFB board assured Dr. Mazhar Qayyum to support him actively in this noble cause.

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Modified HoloLens helps teach kids with vision impairment to navigate the social world – TechCrunch

January 29th, 2020 5:50 am

Growing up with blindness or low vision can be difficult for kids, not just because they cant read the same books or play the same games as their sighted peers; Vision is also a big part of social interaction and conversation. This Microsoft research project uses augmented reality to help kids with vision impairment see the people theyre talking with.

The challenge people with vision impairment encounter is, of course, that they cant see the other people around them. This can prevent them from detecting and using many of the nonverbal cues sighted people use in conversation, especially if those behaviors arent learned at an early age.

Project Tokyo is a new effort from Microsoft in which its researchers are looking into how technologies like AI and AR can be useful to all people, including those with disabilities. Thats not always the case, though it must be said that voice-powered virtual assistants are a boon to many who cant as easily use a touchscreen or mouse and keyboard.

The team, which started as an informal challenge to improve accessibility a few years ago, began by observing people traveling to the Special Olympics, then followed that up with workshops involving the blind and low vision community. Their primary realization was of the subtle context sight gives in nearly all situations.

We, as humans, have this very, very nuanced and elaborate sense of social understanding of how to interact with people getting a sense of who is in the room, what are they doing, what is their relationship to me, how do I understand if they are relevant for me or not, said Microsoft researcher Ed Cutrell. And for blind people a lot of the cues that we take for granted just go away.

In children this can be especially pronounced, as having perhaps never learned the relevant cues and behaviors, they can themselves exhibit antisocial tendencies like resting their head on a table while conversing, or not facing a person when speaking to them.

To be clear, these behaviors arent problematic in themselves, as they are just the person doing what works best for them, but they can inhibit everyday relations with sighted people, and its a worthwhile goal to consider how those relations can be made easier and more natural for everyone.

The experimental solution Project Tokyo has been pursuing involves a modified HoloLens minus the lens, of course. The device is also a highly sophisticated imaging device that can identify objects and people if provided with the right code.

The user wears the device like a high-tech headband, and a custom software stack provides them with a set of contextual cues:

Other tools are being evaluated, but this set is a start, and based on a case study with a game 12-year-old named Theo, they could be extremely helpful.

Microsofts post describing the system and the teams work with Theo and others is worth reading for the details, but essentially Theo began to learn the ins and outs of the system and in turn began to manage social situations using cues mainly used by sighted people. For instance, he learned that he can deliberately direct his attention at someone by turning his head towards them, and developed his own method of scanning the room to keep tabs on those nearby neither one possible when ones head is on the table.

That kind of empowerment is a good start, but this is definitely a work in progress. The bulky, expensive hardware isnt exactly something youd want to wear all day, and naturally different users will have different needs. What about expressions and gestures? What about signs and menus? Ultimately the future of Project Tokyo will be determined, as before, by the needs of the communities who are seldom consulted when it comes to building AI systems and other modern conveniences.

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Modified HoloLens helps teach kids with vision impairment to navigate the social world - TechCrunch

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1 lakh kids born in Bangladesh with blindness risk every y… – United News of Bangladesh

January 29th, 2020 5:50 am

Ophthalmologists here have said over 100,000 children born in Bangladesh every year face the risk of blindness and they may lose the eyesight anytime if not given proper treatment.

They highlighted this at a roundtable discussion titled ROP Prevention & Treatment: Scope & Potentials at Press Institute Bangladesh (PIB) seminar room jointly organised by Orbis International and PIB on Monday.Referring to statistics of the United Nations, Orbis Senior Medical Specialist Dr Lutful Husain in his keynote presentation said around 3 million babies are born in Bangladesh every year on average.

Of them, at least 600,000 children are born prematurely. Of these premature babies, 20-22 percent kids face the risk of being affected with retinopathy of prematurity (ROP), he added.

PIB Director General Zafar Wazed, Bangladesh Medical and Dental Council (BMDC) President Prof Mohammad Shahidullah, Orbis International Country Director Dr Munir Ahmed, OBGyn Society of Bangladesh ex-President Prof Rowshan Ara, Bangladesh Eye Hospital Consultant Dr Kazi Shabbir Anwar, among others, spoke at the programme.

According to ophthalmologists, ROP is a vaso-proliferative disorder affecting the avascular retina of babies who are born prematurely -- before 34 weeks of gestation.

Dr Lutful Husain said most parts of the country lack ROP service facilities as they are concentrated mainly on divisional cities and large district towns.

BMDC President Shahidullah laid emphasis on devising a short-term strategy to overcome the shortcoming.

Zafar Wazed stressed the need for building more close relations between media and health institutions for raising awareness.

Leading ophthalmologists, neonatologists, gynecologists and obstetricians, senior government officials, representatives from eye care institutions, non-government organisations, and other stakeholders took part in the discussion.

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UWF researcher earns grant to study retina regeneration in fish – UWF Newsroom

January 29th, 2020 5:50 am

The research will focus on using Clustered Regularly Interspaced Palindromic Repeats, or CRISPR, genome-editing techniques to explore how zebrafish regenerate the retinal cells that receive light and start the visual process.

Taylor said the research could eventually have applications for treating blindness in humans.

(MiR-18a) might be extremely important for starting the regeneration process and at least helping to produce new photoreceptor cells, Taylor said. Thats really what we want to get at because in humans a lot of the retinal diseases destroy photoreceptors. So, we want to find ways to regenerate those cells in humans so that vision can be restored.

Zebrafish can fully regenerate cells in their eyes even after extensive damage.

In other animals, including mammals, damage to the retina causes permanent blindness, but zebrafish can fully recover from this, Taylor said. Otherwise, our retinas are almost identical in terms of how they work and how theyre structured.

Taylor has used CRISPR to create zebrafish without MiR-18a, a molecule that regulates regeneration in the eye, to see how their vision recovers in its absence.

Fish without this molecule have an exaggerated regeneration response, Taylor said. They produce more new cells and photoreceptors than normal fish would. We think this process is critical for regulating retinal regeneration.

Taylor has studied retinal regeneration at UWF for more than three years.The grant will fund three years of work and will support research positions for undergraduate and graduate students.

For more information about the UWF Department of Biology, visit uwf.edu/biology.

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What having a heart attack taught me about Brexit – The Guardian

January 29th, 2020 5:50 am

Something can be massive without being obvious, as I learned by having a heart attack. The symptoms should not have left doubt: sudden, severe chest pain; a burning lash down the left arm; air refusing to enter the lungs; a vibrating sense of ill-being, the world turning sour and dark.

Still I hesitated before getting help. At some level I knew what was up, but really not wanting a heart attack seemed like a compelling reason why I wasnt having one. Forty-five seemed a bit premature for that sort of thing. Later, recovering in hospital, I was described as young with a frequency that would be flattering in other contexts.

In hindsight, the symptoms had started a lot earlier. The feeling in my chest was an extreme variant of tightness I had felt before while running, and dismissed as unfitness. (Turns out: angina.) Such is the awesome power of denial, a psychological term cheapened by overuse. We are always describing others and even deprecating ourselves for being in denial of the smallest things, which is itself a kind of denial. Admitting shortsightedness around minor flaws is a way to avoid admitting blindness to much worse.

I was still hooked up to cardiac monitors and full of morphine, barely an hour after the insertion of two stents, when the metaphorical comparisons first presented themselves. The Labour party had ignored vital warning signs for years, failing to change course when avoidance of calamity was still available. So too had Britains pro-European campaign. I wont stress the point too hard, being on doctors orders to minimise stress of all kinds. The compulsion to turn even my own medical emergency into a political analogy flagged a lifestyle habit in need of healthy adaptation. A month of convalescence has taught me to care differently. Not less, but less angrily.

It pushes the metaphor too far to say that Brexit broke my heart. I was culturally and emotionally attached to the European project and still believe UK involvement has improved this country. It will hurt on Friday night when EU membership ends, but not as much as it hurts when a blocked artery cuts off blood to the left ventricle. Having survived one of those experiences, I am palpably more relaxed facing the other one. It also helps to understand those hearts that will leap at 11pm on 31 January.

That sensitivity does not include deference to asinine Tory MPs licking their lips and commemorative stamps with triumphant relish. One of their number, Mark Francois, says he will stay up all night to watch the sun rise on a free country. Neither he nor any of his co-fetishists has satisfactorily explained what, in practice, they will be free to do on Saturday that is forbidden today.

In truth, the measurable liberties available that dawn will be European ones, preserved thanks to a transition period that the all-nighter Brexit celebrants resent as deferral of a greater rupture.

But there I have lapsed into another bad old habit. Remainers lost the argument with arch, eye-rolling negativity. In 2016 the pro-European case was made exclusively in terms of loss forfeited growth, shrunken prestige, jettisoned jobs while the leavers advertised gains. After the referendum, those Brexit promises were assailed by fact-checkers, myth-busters, expert debunkers, but what was the counter offer? What would leavers get in exchange for surrendering a prize for which they had voted, to which they were democratically entitled and which they had not yet received?

On we went, rubbishing the idea that Brexit was a bounty of freedom, sovereignty and control, irritating more than we converted, until Boris Johnson came along to lift the siege. By December, the liberation he could realistically offer voters wasnt from Europe any more, it was from the argument encircling them. It was from us, the remainers.

Johnsons winning formula was to downgrade the promise of Brexit from reward to relief, which was easier to deliver and still sounded marvellous. His opponents complain that the Boris brand of optimism is fraudulent, but that doesnt matter when it is unrivalled in the market.

Pro-Europeans got stuck in a quicksand of nostalgia, rosily tinting the epoch of unchallenged EU membership as a golden age of moderation. It was easy to see it that way as the Conservative party waged war on economics and geography, making dissidents of its sanest MPs. But the remainer lament often sounded like privilege drowning in self-pity, which isnt any more attractive in politics than in other walks of life. We had facts on our side, certain ours was the rational position. The failure to change minds just seemed to prove that rationality itself was in peril. Donald Trump marauding from the White House supported that hypothesis. But for all the solidity of our claims, the case we built from them was hypothetical. Brexit hadnt happened yet, so we couldnt convincingly call it a disaster. Nothing, it seemed, was really happening, despite the frenzy in Westminster.

The whole of politics between the referendum and the 2019 election seems to have been conducted in zero gravity. Arguments that should have weight had none and any crazy notions, once hurled, could fly around with infinite momentum. Only in the unique conditions of space flight could a man built like Johnson cavort like a gymnast. The landing begins on Friday. The country will soon feel the friction of re-entry into a thicker political atmosphere.

The prime minister is already feeling the pressure of earthly decisions: high-speed rail; Chinese involvement in 5G infrastructure; the divergent pulls of strategic cosiness with Donald Trump and trade continuity with Europe. Each choice makes new enemies and limits future choices. Johnsons method so far has been to campaign against the very idea that government is difficult. It is certainly easier without effective opposition, but that advantage cannot endure forever.

The price of victory on a promise to get Brexit done is getting it done. On Friday we cross the threshold where Brexit must breathe the same air as other political projects. It sheds the immunity of abstraction and enters the realm of evidence. There will be no bracing inrush of liberty to get leaver hearts pumping, and no sudden cataclysm to vindicate remainers. If ending EU membership proves to be a mistake it will be a gradual tightening, a slow burn; the kind of problem that is easier to deny than to own. Massive, not obvious.

Rafael Behr is a Guardian columnist

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The Most Important Social Skill You Can Master, According to a Harvard Business School Professor – Worth

January 29th, 2020 5:50 am

Laura Huang on the keys to emotional intelligence.

Self-effacing and funny, Harvard Business School professor Laura Huang hardly exudes the cutthroat mien you might expect from her impressive credentials, which include a PhD in management from the University of California, Irvine and an INSEAD MBA. That kind of surprise is one of the key points of her new book: In Edge: Turning Adversity into Advantage (Portfolio, January 2020), Huang argues that all of us can turn hardships into advantages, if we do so with authenticity. Laced with anecdotes like the time Huang was nearly thrown out of Elon Musks office and examples of unexpected triumphs from leaders like the Soros Funds CIO Dawn Fitzpatrick, Edge is Huangs primer for how and why entrepreneurs should best employ tools like emotional intelligence. She spoke with Worth about how shes done this in her own life, what a Texas gas station chain has in common with the most luxurious Swiss watch companies and why delight is such a key element of success.

Q: You write a lot about social skills. What are the most important ones, and how are they best deployed? A: When we think about social skills, we often think about things like being charismatic and being able to influence others, but social also means that we have a deep sense of who we are, as well as a deep sense of who our counterpart is, and where theyre coming from.

When were able to do that, were able to influence and interact in a much deeper and much more authentic way. We tend to think of interacting with other people almost as something manipulative, but its not. People are going to have first impressions of us, regardless of whether or not we guide them to who we authentically are. The more that were able to deploy those skills, the better off those relationships will inevitably be.

Can those skills be learned? Not everyone has a great read on their own perceptions, let alone how other people perceive them. It absolutely can be learned, but it takes a lot of mistakes and failures and embarrassment, and not everyone is willing to put themselves out there. Getting these types of social skills really depends on being able to laugh at yourself and to find ways to help others laugh at themselves. Its really important that were not only more self-aware, but also more aware of other people and how they might be making mistakes and feeling embarrassed.

Tell me about your career path.I was an engineer by training, worked in engineering, worked in consulting, was an investment banker for a while. The topics that I chose to study, intuition and gut feel, were based on experiences that I had prior to becoming an academic. People told me, Dont pursue these ideas. Its career suicide. I think its something that everyone was curious about, but no one wanted to be the person to try and quantify something as obtuse as gut feel. To some extent, my nontraditional path gave me the ability to study it.

What is advantage blindness?Advantage blindness really means not being able to see the privileges or advantages that we have. The more we obtain success, the more important it is to be aware of our advantage blindness. But the more successful we become, the more likely we are to forget our uphill climb to our position, the feelings and the thoughts that we had to get there, and in turn, the more we are blind to our situations of success and achievement. We all have advantage blindness to some extent.

When did you start writing about the idea of privilege, which has become such a loaded term? Over a decade ago, I was studying organizations and looking at people who were feeling like they were constantly facing barriers and feeling disadvantaged in terms of not getting promoted or placed on coveted projects. They were leaving those organizations and going into the startup world, where they could call their own shots. But they still felt just as discouraged and frustrated, because they still were facing disadvantages, and they still were facing biases and being underestimated.

Because were in a socially embedded system, were always going to have that. The privilege piece is that there are certain people who naturally seem to be in a position of privilege based on their education, based on who they are, based on the perceptions that other people have of them. I always said that when you dont have that privilege, you can make your own privilege. But even that had this loaded connotation.

I still think that privilege doesnt necessarily have to be a negative thing. It can mean youve earned it, but it can also mean that you have some sort of an unfair advantage, and that unfair piece is what bothers us. The advantage piece doesnt bother us when its based on a value we provide or a way that we enrich. When I break up privilege and disentangle the unfair piece from the advantage piece, I find that we then understand privilege in a different way.

Speaking of unfair situations, I was struck by your description of your high school math teacher, who prevented you from joining the advanced class, even though you excelled at math. Still, you write that he remains your favorite teacher.

It clearly was bias, but as a 14 year-old, I didnt quite get that yet. But even looking back, Im so grateful to that math teacher because I learned more from him than I had learned from any other teacher that I had had, even ones that treated me very, very fairly, which suggests that this is a really complicated thing.

Its a personal thing when were underestimated by people like our math teachers. But when I look beyond that and see the greater lessons, Im able to say, look, its not quite that cut and dried.

A lot of times we talk about the system, and making sure that its meritocratic, without bias and discrimination. I totally agree with that premise, but at the same time, its important to understand that systems are not going to always change. If they do change, theyre not always going to change in the ways that we think they should, or that they ideally should.

Not only is there this element of needing to change things from the outside in, but we also need to empower people from within so that we can change things from the inside out.

Had we eliminated this teacher from the teaching system, we also would have been losing a brilliant educator who provided a lot of value within the educational system.

Youre an Asian American woman. I know that biases can come in all forms, but Im wondering, do they all have equal weight in influencing behavior?

Thats a great question. What I try and emphasize is that theres the typical cast of characters that we bring up, like being women, people of color, our sexual orientation and class, but everybody has something, some hang up, or something that people perceive you as.

We should not be in a bias Olympics to see who has it worse, because no ones ever going to win that. Were all going to be able to feel personally affronted in different ways.

I remember Ronan Farrow saying that he constantly hears, Oh, youre the son of Mia Farrow. Youre only getting access to these people because of who you are. Thats his something. He has to constantly show that hes competent, and that his writing is good and that somehow, he would have still gotten to where he is now. Maybe he would have had a different path, or a different trajectory, but he still would have gotten to that ultimate endpoint, regardless of those other things.

How do you advise employees to overcome their own implicit biases, as well as the biases projected onto them?

The overarching thread of my book is understanding that, while hard work is critical, it alone is not enough, because there are all of these perceptions, attributions and implicit stereotypes and perceptions that are our own, as well as ones that are projected onto us. We dont always have the opportunity to show how we enrich and provide value.

How can we get that initial opening into having somebody seeing us for who we are? How can you delight somebody else? How do you get that catalyst so that somebody stops and says, Huh, I didnt quite think that about this situation or about you. And then once you get that opening, you can really show how you enrich and continue to guide. Companies have to do this all the time, to stay nimble and show that theyre relevant in the market. People can do this as well.

So what are what you call the basic goods that you would implement as part of that strategy?

These are your superpowers, the central value or competency that you provide. This takes a lot of thought and self-reflection, and my book is not a prescriptive recipe for how to gain your edge, its a perspective on how to think. And the more personal you make it, and the more you think about your own basic goods and your own ways of guiding, the more effective youre going to be at getting your edge. Its really a way for you to understand how you add value to various scenarios and target audiences.

Do you have examples of companies or individuals that have mastered this?

Buc-ees, the Texas gas station chain. When they started, their basic goods were ice, cheap gas and clean bathrooms. What they realized was that when people are driving on road trips, they stop at gas stations to use the bathroom, to get gas and, in Texas where they started out, ice for their soft drinks. They built on those basic goods, and now theyre just this spectacular organization that has the longest carwash in America, the cleanest bathrooms in America, their own branded merchandise, and branded food and all of these things that they built off of what were their basic goods.

You also write about the Swiss watch industry, and how it flipped the narrative of being a business losing to technology to their advantage.

My colleague Ryan Raffaelli studied the Swiss watch industry in-depth. He analyzed companies like Hublot and Montblanc and founders such as Jean-Claude Biver, who really had a vision for technical tradition and advanced engineering, which started from being enamored by model trains and electric trains.

Biver really understood that something that was once an advantage, the privilege that they once had, was changing and that now they were facing this disadvantage of digital, cheaper options that were telling time just as well. He went back to his basic goods and he realized it was not about telling time, it was about the fact that watches have a lot of meaning, a lot of tradition. Its something that people pass down from generation to generation.

How long did it take to go from identifying a disadvantage to reclaiming their market share?

It was over the course of decades. Whats really key here is that a lot of times when were trying to flip those stereotypes in our favor, or trying to position ourselves, we think that its a once and for all thing, but its not just like flipping a switch.

You have to continue to guide the fact that watches are stylish, have deep meaning, have this tradition of advanced engineering that distinguishes their products against competitors like smartphones or digital watches that help you tell time. The guiding process continues.

Incongruity was a word that came up a lot in your writing. Why is it important to understand incongruity?

Thats your signal that something has gone awry, or that people arent seeing you in the way that you authentically are, or that youre like a watch company that is about to be outdated and overtaken by another company. The incongruity is when factors dont add up, and its a window into understanding the gaps in value. And theres a lot of really amazing, disruptive and very innovative things that come out of obstacles and incongruity.

Whats an example of a company missing the incongruity?

The Juicero company was trying to sell app-enabled juicers for $699. You had to buy special packs of vegetables and fruits, but it turned out you got the same results just squeezing the packs with your hands. And people asked, why do we need a machine that costs $699 to squeeze fresh juice when you can squeeze it with your hand?

There was something that was off around the story that the company was telling, which was that every household in America is going to want one of these, look at our potential market size. The investors had the same outlook, behaviors and background, and were very motivated by being able to press a button on their smartphone from bed and have fresh squeezed juice immediately. Outside of that group, the market opportunity just wasnt there.

You talked about following worth, rather than following money. What do you mean?

A lot of hard data is actually not that hard. Its hopes and dreams and guesses. Even though our financial projections are in numbers, theres a very real possibility that it can never go that way, that were not going to achieve that hockey stick growth. So when we think about the worth of something, we should ask: What are we trying to achieve? What are the real milestones? How far are we from those milestones? Whats the distance between where we are and what were trying to achieve? Whats the distance between where we are as an individual, and what we think were worth, and what other people think were worth? That gives us a much richer picture than a definitive sort of analytical hard number.

Is that a difficult concept to understand if youve been trained to analyze things in a more empirical way?

We have these false dichotomies: If youre logical, then youre not emotional. If youre emotional, youre not logical. And when we talk about gut feel and intuition, well think, Thats emotional, its subconscious, its biased.

But in fact, like gut feeling, intuition is something thats really emotional and cognitive. Its based on our experiences and our patterns and pattern matching. And even though we cant necessarily put our finger on it, its something thats not just emotional. It incorporates things that have been rational and have been a part of what weve considered and been very thoughtful about in the past as well. The more that were able to hone that intuition, and hone the way we think about worth, the better off were going to be.Youve mentioned delight. Why is it so important?

Delight is a key ingredient in giving yourself the opportunity to show how you enrich and provide value. The better off you know yourself, the more youre able to give your unique personal flavor to the things youre working on.

Remember the first time that you ever rode in an Uber? Forget all the other stuff that happened with Uber subsequently. The first time you rode in an Uber, theres this simultaneous sense of oh my gosh, this is weird. This is cool. This is scary. Im in a strangers car. It was like all of these feelings where the emotions and the rationality were intersecting.

Are younger people better at finding ways to pivot and delight than older people?

We tend to think that they would be, but theyre not.

One of the things thats really interesting in terms of the generational piece, is that were in this ethos where parents are trying really hard to give their kids an advantage. Were seeing things like Lori Loughlin and Felicity Huffman who are buying their kids way into college. Even in a more benign way, we see parents who are paying for extra tutors for their kids, getting them private coaches and that sort of thing. Ive found that parents who teach their kids how to create their own advantage, and gain their own advantage, those kids do much better because it is so situational. Those kids are able to go into situations and think, I know how to delight this person. They intuitively get it.

Has the perception of your work changed among your academic colleagues?

When I first started studying this, a lot of the literature and theory was around disadvantage and inequality and meritocracy in organizations and in entrepreneurship. And then a couple of years ago, I was just getting so many questions like, We see women are only getting 2 percent of venture capital financing even though they represent more than 50 percent of the firms being started. What can we do about this? What strategies can we try out?

I hope that Im still going to continue to be seen as somebody who really values the research and the research-backed rigorous findings, as well as what we can do about this. A lot of times it is one or the other: If youre practical, then youre not into rigorous research, and if youre into rigorous research, you cant be practical. Im really trying to marry the two.

Do you test your theories out on your family?

My daughter has always loved princesses. She kept insisting that she wanted books about them. My husband and I said no, because we want her to be more than a princess. We decided to tell her these delightful stories about a princess who was also an engineer and a princess who was also a chemist. These were improvised, but this is delight at its best in my personal life. Now my daughter wants to be a chemist and a princess.

Inspiration and advice for female leaders, founders and investors.

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Time to end the Blame Game – NWAOnline

January 29th, 2020 5:50 am

As Jesus went along, he saw a man blind from his birth. And his disciples asked him, "Rabbi, who sinned, this man or his parents, that he was born blind?" John 9:1-2

In life, some things are useful and others aren't. Blaming one's circumstances, one's birth right, one's parents, one's environment, for what kind of work we do or what kinds of faults we have is astonishingly useless. It is useless, misleading and harmful because it takes a person in a direction where there is almost no help for them -- almost no way for them to claim the inner power and the freedom that God has built into their very souls.

Another thing that is often equally useless -- equally misleading and equally harmful -- is trying to determine who is to blame for another person's misfortune. How often we have seen someone on the news -- or perhaps even a neighbor -- enduring one hardship after another and then heard others talking about the situation and saying things like: "Well, it is very unfortunate, but if the family only knew how to budget better they wouldn't be in that mess."

Or "It's sad, but what can they expect, they never look after themselves properly -- and they certainly don't take care of each other."

Or "They never had a chance - their parents were just the same."

Assigning blame for one's own misfortune (or for the misfortune of others) is virtually a national sport.

Who sinned? Who is at fault? What caused the problem? These can be good questions. Diagnosis is a very important thing -- as anyone who has gone to a doctor knows. But diagnosis by itself accomplishes nothing. It is what we do afterward that matters -- what we do afterward, and, just as importantly, what we do during diagnosis and what we do even before diagnosis is attempted. It is almost like seeing a person with a flat tire and saying, "Yep, that tire's flat!" and then walking away.

Today we are surrounded by people who live in worlds of blame and bitterness. In the end, the disciples' question about the man born blind is answered in how Jesus responded to that man and what he did as he defended Jesus as the source of his healing -- and then confessed Jesus as his Lord and worshipped him. Why, was he born blind?

"That the works of God might be made manifest in him," is Jesus' response.

This week this world can be full of the news of senseless tragedies: Fault and blame can easily be assigned -- but that is not what is needed. There is blame. There is blindness. And there is blessing. The only thing that can hold us back from experiencing the healing power of God in our lives is our own attachment to blame and our fondness for bitterness.

Time to end the blame game.

Editor's note: The Rev. Dr. Scott Stewart is the pastor of Pea Ridge United Methodist Church and Brightwater Methodist Church. The opinions expressed are those of the writer. He can be contacted at revjstewart@gmail.com or 479-659-9519.

Print Headline: Time to end the Blame Game The "Pit" The "Pit"The "Pit"The "Pit"The "Pit"

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Use preventative care tips to avoid health challenges in the future – Dearborn Press and Guide

January 28th, 2020 6:46 am

If your doctor is always after you to schedule your annual physical examination, there's a good reason: Preventative medicine works.

A preventive care-based approach to maintaining health puts you in the drivers seat, that is you are in charge of maintaining/optimizing your health and well-being, said Arti Madhavan, M.D., Family Medicine Special, Huron Valley-Sinai Hospital.

The New Year is a perfect time to make a commitment to better health. A good place to start is by choosing to make good choices and trusting your instincts when it comes to your body.

Actions such as eating healthy and exercising on a regular basis are some good examples of how to positively impact your health, said Junaed Haq M.D., Henry Ford Health System. Not only will this lead to weight reduction, but it will also have a direct effect on your blood pressure, blood sugars and your mental health status, he said.

Of course, the flip side is also avoiding items known to have negative impacts, like smoking, vaping, sugary drinks and salty snacks, the board-certified family medicine doctor added.

Make sure to get your flu shot if you have not already had it, Haq said. The flu can have significant impacts on ones health and young children and the elderly are especially vulnerable. Thousands of Americans are hospitalized annually with the flu.

Another step you can take is to follow up regularly with your physician as directed if you take prescription drugs. This way you can ensure the medications are doing what they are intended to do, he said.

Preventative care is all about identifying how you can work to improve your overall health as well as catch diseases in their early stages before they manifest themselves clinically. Finding potential problems in the early stages has many benefits, said Madhavan, including:

Being easier to treat and more likely to achieve a cure

Being less expensive to treat. By identifying and treating diseases in their early stages, there are fewer medical expenses involved

Having an improved quality of life and longer lifespan

Avoiding the uncomfortable symptoms associated with chronic diseases, cancer and more if left undiagnosed

Another benefit of preventative care is having a healthcare provider who knows you and your family.

A yearly face to face visit with your physician helps in establishing trust and strengthening the doctor-patient relationship. Its an opportunity to have a customized wellness plan designed for you based on your lifestyle choices, risk factor for diseases, etc., said Madhavan.

That trusted relationship can prove invaluable when addressing issues such as depression, substance abuse or even chronic diseases like high blood pressure or hypertension. Thats because these inevitably require the individual to make treatment and lifestyle choices that are not easy and cause inconvenience and discomfort at least in the short term, he said.

For children, the doctor-patient relationship is critical.

Well child visits promote strong, healthy relationships between the child, parent and the physician which in turn contributes to the optimal physical, mental and social well-being of the child, said Madhavan.

During well child visits, doctors evaluate the child and compare his or her physical development as well as important motor, social and language milestones achieved to the age-expected norms. This can assist in early diagnosis of developmental delays in speech and language, gross and fine motor skills, social skills and cognition/learning early which, in turn, allows resources such as speech therapy, physical/occupational therapy to be implemented faster for a chance at better outcomes, said Madhavan.

Left untreated or undiagnosed, developmental delays are associated with learning difficulties, behavioral problems and decreased functional ability later in life, he said.

Madhavan added that well child visits also provide opportunity for:

Scheduled immunization updates

Discussion of injury prevention measures such as use of helmets, firearm safety, seat belt use etc.

Education regarding diet and nutrition

Parents to discuss any of their concerns in a timely fashion

Providers to screen for any evidence of child abuse or neglect

Patients do not outgrow the need for an annual doctor visit. According to Haq, it is important to stay current through the years on any immunizations that you may be a candidate for based on your underlying medical conditions. Some routine immunizations that are common to all regardless of medical history include the influenza vaccine and the Tdap vaccination that offers protection from tetanus as well as whooping cough. The influenza vaccine is annual and the Tdap vaccination is good for 10 years, he said.

Madhavan outlined general screenings people need at various ages and stages in their lives:

In their 20s and 30s - recommended screenings include depression, alcohol abuse, intimate partner violence and sexually transmitted diseases like HIV as well as cervical cancer screening with a pap smear and HPV testing. People in this age group should also be screened for obesity, elevated blood pressure, cholesterol, diabetes and more.

In their 40s and 50s recommended screenings include depression, alcohol abuse, chronic diseases such as high blood pressure, cholesterol, diabetes and obesity as well as cancer screenings with mammography for breast cancer and screenings for cervical, prostate and colorectal cancers.

Age 65 and over recommended screenings include those for previous age groups plus screening for osteoporosis, especially in postmenopausal women; fall risk assessment in community dwelling older adults; and screening for elder abuse. In addition, males ages 65-75 who have ever smoked are advised to have a one-time screening for abdominal aortic aneurysm completed.

Over age 75, he said the cancer screening decision is an individual one, considering their overall health, prior screening test results and other factors.

In addition, smokers between 55-80 years old who have a 30-pack year history of smoking and are still smoking or quit in the past 15 years are advised lung cancer screening using a low dose Computerized Tomography (CT) scan, he said.

For more detailed information regarding recommended age and gender specific screening guidelines, Madhavan suggested visiting uspreventiveservicestaskforce.org and cdc.gov.

Make your physical, mental, emotional health a priority in 2020 by adopting the practices identified below by Arti Madhavan, M.D., Family Medicine Special, Huron Valley-Sinai Hospital:

Eat healthy

Get adequate sleep

Engage in stress reduction activities such as yoga, meditation, etc.

Regular exercise, whether its organized such as joining a gym or just adopting a more active lifestyle

Stop smoking /vaping

Cut down excessive alcohol intake

Regular medical checkups - at least a yearly physical

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