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Veterinary Medicine Market Emerging Trends to Achieve Significant Growth in the coming Years TechNews.mobi Market Reports – TechNews.mobi

February 12th, 2020 11:47 pm

Veterinary medicines are used for the treatment of animal injuries, infections and diseases. The veterinary medicine include vaccines, veterinary medicines, such as antimicrobial agents, and diagnostic kits to cure the animals from pathogen. Moreover, the medication is also available for animal health care, surgery and preventive services.

The veterinary Medicine market is anticipated to grow in the forecast period owing to driving factors such as increasing awareness towards healthcare of livestock and companion animals and government policies to immunize the animals. Moreover, the inflated R&D investment in this sector, new technology with better therapeutic application and raised quality standards presents the opportunity for the market.

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The global veterinary medicine market is segmented on the basis of product, route of administration, animal type and end user. Based on product, the market is classified as drugs, vaccines and medicated feed additives. On the basis of route of administration, the market is classified as oral, parenteral and topical. On the basis of animal type, the market is classified as companion animals and livestock animals. On the basis of end-user, the market is classified as veterinary hospitals, veterinary clinics, pharmacies and drug stores.

The report provides a detailed overview of the industry including both qualitative and quantitative information. It provides overview and forecast of the global veterinary medicine market based on various segments. It also provides market size and forecast estimates from year 2017 to 2027 with respect to five major regions, namely; North America, Europe, Asia-Pacific (APAC), Middle East and Africa (MEA) and South & Central America. The veterinary medical products market by each region is later sub-segmented by respective countries and segments. The report covers analysis and forecast of 18 countries globally along with current trend and opportunities prevailing in the region.

The report analyzes factors affecting veterinary medical products market from both demand and supply side and further evaluates market dynamics effecting the market during the forecast period i.e., drivers, restraints, opportunities, and future trend. The report also provides exhaustive PEST analysis for all five regions namely; North America, Europe, APAC, MEA and South & Central America after evaluating political, economic, social and technological factors effecting the veterinary medical products market in these regions.

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Tags: Veterinary MedicineVeterinary Medicine MarketVeterinary Medicine Market GrowthVeterinary Medicine Market Size

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Veterinary Medicine Market Emerging Trends to Achieve Significant Growth in the coming Years TechNews.mobi Market Reports - TechNews.mobi

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Veterinary Medicine Market Growth by Top Companies, Trends by Types and Application, Forecast to 2026 – News Parents

February 12th, 2020 11:47 pm

The report is an all-inclusive research study of the Veterinary Medicine Market taking under consideration the expansion factors, recent trends, developments, opportunities, and competitive landscape. The market analysts and researchers have done extensive analysis of the global Veterinary Medicine market with the help of research methodologies such as PESTLE and Porters Five Forces analysis. They have provided accurate and reliable market data and useful recommendations with an aim to help the players gain an insight into the overall present and future market scenario. The report comprises in-depth study of the potential segments including product type, application, and user and their contribution to the general market size.

The Veterinary Medicine market report provides detailed information on key factors, Opportunities, Challenges, industry trends and their impact on the market. The market report Veterinary Medicine also includes company data and its operation. This report also contains information about the pricing strategy, brand strategy and target customer of the Veterinary Medicine market.

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The top Manufacturer with company profile, sales volume, and product specifications, revenue (Million/Billion USD) and market share

Global Veterinary Medicine Market Competitive Insights

The competitive analysis serves as a bridge between manufacturers and other participants that are available on the Veterinary Medicine Market. The report includes a comparative study of Top market players with company profiles of competitive companies, Veterinary Medicine Market product innovations and cost structure, production sites and processes, sales details of past years and technologies used by them. The Veterinary Medicine Market report also explains the main strategies of competitors, their SWOT analysis and how the competition will react to changes in marketing techniques. In this report, the best market research techniques were used to provide the latest knowledge about Veterinary Medicine Market to competitors in the market.

Global Veterinary Medicine Market Segmentation information

The report provides important insights into the various market segments presented to simplify the assessment of the global Veterinary Medicine Market. These market segments are based on several relevant factors, including Veterinary Medicine Market product type or services, end users or applications and regions. The report also includes a detailed analysis of the regional potential of the Veterinary Medicine Market, which includes the difference between production values and demand volumes, as well as the presence of market participants and the growth of each Region over the given forecast period

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Veterinary Medicine Market: Regional Analysis :

As part of regional analysis, important regions such as North America, Europe, the MEA, Latin America, and Asia Pacific have been studied. The regional Veterinary Medicine markets are analyzed based on share, growth rate, size, production, consumption, revenue, sales, and other crucial factors. The report also provides country-level analysis of the Veterinary Medicine industry.

Table of Contents

Introduction: The report starts off with an executive summary, including top highlights of the research study on the Veterinary Medicine industry.

Market Segmentation: This section provides detailed analysis of type and application segments of the Veterinary Medicine industry and shows the progress of each segment with the help of easy-to-understand statistics and graphical presentations.

Regional Analysis: All major regions and countries are covered in the report on the Veterinary Medicine industry.

Market Dynamics: The report offers deep insights into the dynamics of the Veterinary Medicine industry, including challenges, restraints, trends, opportunities, and drivers.

Competition: Here, the report provides company profiling of leading players competing in the Veterinary Medicine industry.

Forecasts: This section is filled with global and regional forecasts, CAGR and size estimations for the Veterinary Medicine industry and its segments, and production, revenue, consumption, sales, and other forecasts.

Recommendations: The authors of the report have provided practical suggestions and reliable recommendations to help players to achieve a position of strength in the Veterinary Medicine industry.

Research Methodology: The report provides clear information on the research approach, tools, and methodology and data sources used for the research study on the Veterinary Medicine industry.

What will you find out from the global Veterinary Medicine Market Report?

The report contains statistical analyses of the current and future Status of the global Veterinary Medicine Market with a forecast to 2026.The report contains detailed information on manufacturers, Veterinary Medicine Market raw material suppliers and buyers with their trade outlook for 2020-2026.The report informs you about the most important drivers, technologies and Trends that will shape the global Veterinary Medicine Market in the near future.The report added an exclusive market segmentation, broken down by Product Type, Veterinary Medicine Market end user and Region.The strategic perspectives on Veterinary Medicine Market Dynamics, current production process and applications.

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TAGS: Veterinary Medicine Market Size, Veterinary Medicine Market Growth, Veterinary Medicine Market Forecast, Veterinary Medicine Market Analysis, Veterinary Medicine Market Trends, Veterinary Medicine Market

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Answers to microbiome mysteries in the gills of rainbow trout – Penn: Office of University Communications

February 12th, 2020 11:47 pm

While many immunologists use mouse models to conduct their research, J. Oriol Sunyer of Penns School of Veterinary Medicine has made transformational scientific insights using a very different creature: rainbow trout.

In a paper featured on the cover of the journal Science Immunology, Sunyer and colleagues developed a method to manipulate the trout immune system to reveal a new understanding of how the animals defend against infection while promoting a healthy microbiome. The work addresses a decades-old question of whether mucosal antibodiesthose present on mucosal surfaces of the body such as the gut, or in the case of fish, the gillsevolved to fight pathogens, or to preserve a healthy microbiome. As it turns out, mucosal immunoglobulins coevolved both roles from very early on during vertebrate evolution.

You might be thinking, Rainbow trout? We fish for them; we eat them, says Sunyer. But it turns out they can also tell us a lot about some fundamental biomedical, evolutionary, and immunological questions.

Specifically, Sunyer and colleagues found that a mucosal antibody, an immunoglobulin known as IgT, is critical both in controlling pathogens and in regulating the microbiome of fish gills, a tissue type that shares similarities with several mucosal surfaces of mammals, such as the intestines.

We found that IgT is playing two paradoxical roleson the one hand reducing bad microbes, and on the other hand promoting the presence of certain beneficial bacteria, says Sunyer. Fish are the earliest bony vertebrates to possess a mucosal immune system, and so the fact that fish possess a specialized immunoglobulin that does both jobs suggests that these two processes are so fundamentally important for vertebrate survival that they arose concurrently, early on in evolution.

For nearly 20 years, Sunyers lab has contributed a steady stream of discovery regarding the evolution and roles of the immune system using fish as model species. In 2010, a seminal paper in Nature Immunology featured on the journal cover identified the role of IgT. It was the first time that fish were shown to have a form of mucosal immunitya more specialized response to pathogens that enter the body from the environment; in this case, through the gills, skin, and fish gut.

Before that we thought only four-legged animals, or tetrapods, had mucosal immunity, Sunyer says. That study demonstrated the induction of potent IgT responses upon infection with a mucosal pathogen.

The group also showed that IgT coats a large portion of the bacteria that are part of the fishes microbiome, the community of bacteria and other microbes that dwell on various tissues of the animals bodies. That got the researchers thinking about which function arose first for vertebrate mucosal immunoglobulins: fighting pathogens or preserving a healthy microbiome.

In mammals, the immunoglobulin IgA seems to have analogous function to IgT in fish, Sunyer explains. In the last few years there have been some key studies showing that IgA is required to keep the mammalian microbiome in check. In mice and humans lacking IgA, their microbiome changes: The beneficial bacteria go down and the potentially disease-causing bacteria go up.

A weakness of these studies in mammals lacking IgA, Sunyer notes, is the inability to tease apart the precise role of IgA in preserving a balanced microbiome, since the lack of IgA from birth precludes the establishment of a healthy microbiota in these animals.

To better understand the roles of mucosal immunoglobulins in preserving a healthy microbiome, Sunyer and colleagues developed a model in adult fish where researchers could temporarily deplete them of IgT, lasting about two months.

By doing so they could study the role of IgT in preserving, rather than establishing, a healthy microbiome, while also evaluating the susceptibility to pathogens of fish lacking IgT.

When they depleted IgT, the researchers found that levels of a mucosal parasite greatly increased, underscoring the immunoglobulins role in defending against harmful invaders. But they also saw a dramatic impact on the microbiome composition: IgT-depleted fish lost the IgT coating on the bacterial community in their gills and had more bacteria escape from gill surfaces and enter the tissue layer beneath, leading to tissue damage and inflammation.

Looking closely at the bacteria coated by IgT in normal animals, the research team found that IgT targeted specific species over others. These species included bacteria associated with both health and disease states in fishsimilar to what had been found with IgA in mammals.

Critically, the authors found that the overall microbiome in IgT-depleted fish was significantly altered, in a shift known as dysbiosis. The overall diversity of bacteria present decreased, numbers of beneficial bacteria such as those producing short-chain fatty acidscritical for the maintenance of tissue integrity and immune homeostasisalso decreased, while disease-associated species increased.

We see that there seems to be specific microbes that have to be controlled, says Sunyer. Either they are harmful and tend to escape and cause problems in the nearby tissue in the absence of IgT, or perhaps they are beneficial but require IgT to colonize the mucosal surfaces. In both fish and mammals, it now seems apparent that their respective mucosal immunoglobulins do these jobs.

One great benefit of the researchers IgT depletion technique is that its temporary and performed in adult animals. After several weeks of depletion, the fish IgT levels return to normal. Thus the researchers were able to track the microbiome as IgT came back, observing what amounted to recovery; the microbes in the gill regained IgT coating, the microbiome was restored to its initial composition, and the tissue damage and inflammation that had been seen around the gills was reversed.

In microbiome studies, recovery is a very important point, Sunyer says. When you take an antibiotic, you can perturb your microbiome to the extent that recovery may take a very long time, but the perturbation we used, of removing IgT, had a profound but transient effect on the microbiome composition, which underwent a speedy recovery.

As more and more scientific studies identify links between the microbiome and various aspects of health from maintaining a healthy weight to the risk of cancer or even neurological conditions like Alzheimers and schizophrenia, Sunyer is hopeful that his fish model will find even more applications.

Studying only mammalian models is not going to be enough to understand the role of the microbiome in all of these physiological processes, says Sunyer.

Because the symbiotic relationship between vertebrates and their microbiome is very ancient, and one which first flourished with the emergence of mucosal immunoglobulins in fish, Sunyer says that rainbow trout will help us discover the underlying mechanisms by which the interactions between immunoglobulins and the microbiome influence immunity, metabolism, cancer, and much more.

These studies, Sunyer adds, will have a crucial impact on the potential uses of specific species of fish bacteria as probiotic agents that may stimulate the immune system to protect against pathogens. With every other fish that we eat deriving from fish farming, an industry plagued with emerging pathogens, novel therapies, such as probiotics, are in urgent need.

J. Oriol Sunyer is a professor of immunology and microbiology in the University of Pennsylvania School of Veterinary Medicine.

Sunyers coauthors on the study from Penn Vet were co-first authors Zhen Xu and Fumio Takizawa, Yasuhiro Shibasaki, Yang Ding, and Yongyao Yu. Co-authors from the University of New Mexico were Elisa Casadei, Thomas J. C. Sauters, and co-corresponding author was Irene Salinas.

The study was supported by the National Science Foundation (Grant 1457282), the U.S. Department of Agriculture (Grant USDA-NIFA-2016-09400), the National Institutes of Health (grants GM085207-09 and GM103452), the National Natural Science Foundation of China, the Japan Society for the Promotion of Science, JSPS Overseas Fellowships, and the University of New Mexicos Initiative for Maximizing Student Development Program.

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VERIFY: Could the dead birds from China seized at Dulles carry Coronavirus? Breaking down this and other questions about the incident – WUSA9.com

February 12th, 2020 11:47 pm

DULLES, Va. Question 1:

Is it possible that these seized birds carried the latest strain of the Coronavirus, that is spreading across China?

Answer:

Yes, but unlikely. Various experts told The Verify Team, that while it's possible, the likelihood of birds carrying the latest strain, remains unlikely.

Sources:

Process:

When news broke about the Dulles seizure of birds, the response was widespread on social media, with concern that this could mean the spread of that latest strain of Coronavirus.

"Can these spread the Virus," one person asked.

"Those birds (were) probably carrying the Coronavirus," wrote another.

To find out if this is actually true, the Verify Team called Mohamed Medhat El-Gazzar from Iowa State University and Siba Samal, from The University of Maryland.

"We don't know much about this virus," said Samal. "So we need to take precautions."

Samal said that birds do have "their own Coronaviruses," just like all animals do. He said it was unlikely that it would jump from species to species, although it is possible.

"We know this jumped from species to species before," he said. "So the possibility lies."

El-Gazzar agreed.

"It is unlikely that birds carry this specific outbreak virus," he said. "Because it is thought to come from bats, which are mammals."

That being said, El-Gazzar said we shouldn't take the possibility lightly.

"That does not mean it's impossible," he said. "To cross-species."

RELATED: Dulles customs seizes dead birds in passenger baggage from China

***

Question 2:

Did the spread of the current Coronavirus strain start when someone ate "bat soup," like many are claiming online?

Answer:

Likely not. The origins of this latest strain remain unclear. While the strain likely did come from an animal, there's no evidence that bat soup had anything to do with this.

Sources:

Process:

Soon after news came out about the dead birds seized at Dulles Airport, the online comments began. Many started to spread rumors about how the latest strain of the Coronavirus first began.

"I read somewhere it started from bat soup," wrote one person.

"I read it was from eating wolves," wrote another. "And Koala bears."

To find out the truth, the Verify Team turned to the Centers for Disease Control and Prevention. The CDC said that this latest strain of coronavirus was likely caused by animal-to-human transmission.

"Early on, many of the patients in the outbreak..." wrote the CDC. "Reportedly had some link to a large seafood and animal market, suggesting animal-to-person spread."

The CDC also said that the latest strain is a "BetaCoronavirus," which like MERS and SARs have origins in bats.

However, there's no evidence indicating that bats, in particular, were the cause.

"I don't think anyone in the world knows what actually happened," said Assistant Professor Mohamed Medhat El-Gazzar, from Iowa State University. "In these cases, it's very hard to pinpoint where it started."

Professor Siba K. Samal, from the University of Maryland, said that it was very unlikely that it came from "Bat soup," as has been stated online.

"The virus is much less likely to survive if cooked," he said.

Question 3:

Has the U.S. completely stopped travel from China to the United States?

Answer:

No. Although there are some major restrictions.

Sources:

Process:

In the aftermath of the dead birds being seized at Dulles, there were a lot of questions about what travel restrictions exist between China and the United States.

"I thought they stopped travel from China," said one person on Facebook.

To answer that, the Verify Team turned to the U.S. Department of Health and Human Services, and the Bureau of Consular Affairs within the U.S. Department of State.

Secretary of HHS, Alex Azar announced the restrictions on Jan. 31, 2019. United States citizens, permanent residents, and their families are still able to travel from China, although everyone else is restricted.

"These prudent and targeted actions will decrease the pressure on public health officials," he said at the time. "Screening incoming travelers, expedite the processing of U.S. citizens returning from China, and ensure resources are focused on the health and safety of the American people."

Currently, U.S. citizens returning from Hubei Province will face up to 14 days of mandatory quarantine, according to the policy. U.S. citizens from the rest of mainland China will undergo "proactive entry health screening at a select number of ports of entry," and up to 14 days of "monitored self-quarantine."

Azar also announced that President Trump signed a "presidential proclamation" suspending entry into the U.S. of all foreign nationals, except the immediate family of U.S. citizens and permanent residents.

The Bureau of Consular Affairs has also issued a pretty strong warning to any U.S. citizens wishing to travel overseas.

"Do not travel to China," they wrote.

The BCA also announced that Chinese authorities have "suspended air road and rail travel in the area around Wuhan and placed restrictions on travel and other activities throughout the country."

RELATED: VERIFY: Is it too late to get the flu shot? Is this year's vaccine not as effective?

RELATED: VERIFY: Are our pets at risk of getting the latest strain of coronavirus?

RELATED: Airbnb suspends bookings in Beijing amid coronavirus outbreak

RELATED: Official: Four Virginia high school students under self-monitoring at home for coronavirus

RELATED: Dog masks exist, and sales have spiked as Coronavirus spreads

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Audit: Some WSU employees misreported time worked and absences – Seattle Times

February 12th, 2020 11:47 pm

PULLMAN Some employees of Washington State University were responsible for the misappropriation of thousands of dollars between 2014 and 2019.

Thats according to a new report by the state auditors office.

The Moscow-Pullman Daily News reports that the university initiated an investigation into several cases of employees misreporting time worked and leave of absence used, which totaled more than $12,000.

The audit found that an employee of the College of Nursing did not properly report leave of absence multiple times between April 2016 and June 2018.

The audit also found two WSU School of Music employees were overpaid by a total of $2,895.61 between August 2014 and February 2018 by claiming hours not worked.

An employee with the College of Veterinary Medicine was overpaid by $6,448.56 between November 2017 and November 2018 by claiming hours not worked. The employee was fired for abandonment of post.

A University Advancement employee, who was overpaid by $2,894.38 between March 2018 and February 2019 for claiming hours not worked, resigned from WSU.

The auditors office recommends WSU strengthen its oversight and monitoring of the reporting and use of leave balances.

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UWMadison researchers lead efforts to understand, thwart new coronavirus – University of Wisconsin-Madison

February 12th, 2020 11:47 pm

The 2019 Novel Coronavirus (2019-nCoV), portrayed in an illustration created at the Centers for Disease Control and Prevention. Alissa Eckert, MS; Dan Higgins, MAM

Back in 2016, when Zika virus first began to cause infections in the Americas, University of WisconsinMadison researchers pulled together a coalition of scientists to study the virus and openly share their data for others.

Two weeks ago, those researchers David OConnor, professor at the UW School of Medicine and Public Health, and Thomas Friedrich, professor in the UW School of Veterinary Medicine used the 2016 playbook to start planning efforts to study the novel coronavirus that first emerged in Wuhan, China, in late December 2019.

The virus, which causes flu-like symptoms and respiratory illness, has sickened more than 43,000 people in China and across several nations, according to health officials. At least 1,018 people have died.

David OConnor

Thomas Friedrich

Within the next few weeks, Friedrich, OConnor, and their interdisciplinary partners hope to begin studies to better understand the novel coronavirus, 2019-nCoV.

We are working together to develop a plan to build out nonhuman primate models to test medical countermeasures such as vaccines and therapeutics, says OConnor. We want to make sure we are recapitulating the kind of clinical signs (of virus infection) that happen in people.

The researchers are interested in understanding how much of the virus makes its way into the body and in bodily fluids; where in the lungs the virus infects; and in creating opportunities to test new vaccines and antivirals. They also hope to look at how the immune system responds and whether there are indicators that can help clinicians distinguish who might be at risk for developing severe disease.

Yoshihiro Kawaoka

At the Influenza Research Institute (IRI) in Madison, Professor of Pathobiological Sciences Yoshihiro Kawaoka is also preparing to study 2019-nCoV.

Among the research questions he hopes to address is the efficiency with which the natural virus transmits among animal models for disease. The novel coronavirus is capable of transmitting from person to person, but it most likely originated in bats. However, as with other coronaviruses known to cause significant illness in humans, such as SARS-CoV and MERS-CoV, the virus likely passed through another animal before becoming infectious in humans. Researchers have not identified the animal or animals involved.

With SARS, the virus passed to humans through contact with civet cats, and with MERS, through dromedary camels.

Kawaoka is also interested in studying how the virus causes illness and what cells the virus is capable of infecting. The results of the work could be used to help develop treatments and vaccines to protect people against infection.

The work at IRI will be conducted in a Biosafety Level 3 Agriculture (BSL-3 Ag) laboratory, which is just below Biosafety Level 4. The Centers for Disease Control and Prevention guidelines call for research using the 2019-nCov virus to be conducted in a BSL-3 laboratory since important aspects of how the virus causes disease and transmits are not well understood.

We are using SARS as a biosafety and biosecurity model for this coronavirus because we dont know enough about the virus yet, says Rebecca Moritz, Responsible Official and the Institutional Contact for Dual Use Research at UWMadison. The SARS coronavirus caused an outbreak in more than two dozen countries in 2003, infecting more than 8,000 people and killing 774.

My lab is interested in why things like this happen, why do viruses emerge from somewhere and begin causing diseases in humans? What are the evolutionary pathways they need to take hold, and how do they adapt to our immune responses?

If we can understand that, hopefully we can erect more barriers to prevent this sort of thing from happening in the future.

Thomas Friedrich

The university has worked proactively with Public Health Madison and Dane County, the Wisconsin Department of Health Services, the State Lab of Hygiene, infectious disease specialists and University Health Services to prepare to conduct the research.

We are requiring researchers to monitor their health and to take their temperatures twice per day, says Moritz. Fever is one symptom of 2019-nCoV illness. If they are not feeling well, our exposure control plans in place involve infectious disease and public health authorities. We would quarantine and test them for the virus.

With the studies planned, UWMadison researchers are at the leading edge of efforts to understand an emerging human illness. Kawaoka stresses that basic research studies are necessary to combat pathogens that make animals and people sick. OConnor, Friedrich and their collaborators plan to once again share their data publicly so that other researchers may use it to advance the science, and hopefully lead to efforts to improve and protect human health.

Says Friedrich: My lab is interested in why things like this happen, why do viruses emerge from somewhere and begin causing diseases in humans? What are the evolutionary pathways they need to take hold, and how do they adapt to our immune responses? If we can understand that, hopefully we can erect more barriers to prevent this sort of thing from happening in the future.

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Scenes from CSU’s 150th birthday celebration – Source

February 12th, 2020 11:47 pm

You only get to celebrate your sesquicentennial once, and on Feb. 11, 2020, thats just what Colorado State University did.

For a birthday this big, the celebration started a day early and in two cities. On Monday, the College of Agricultural Sciences held a groundbreaking ceremony for the Temple Grandin Equine Center on the Foothills Campus. The center will celebrate and elevate the role of the horse in society through the physical and emotional benefits of serving those in need, integrating research and education in order to promote evidence-based practices of equine assisted activities and therapy.

Tuesday morning started with representatives from CSU appearing at the State Capitol in Denver to receive an official proclamation from the Colorado Legislature congratulating the states only land-grant university on its 150th anniversary. The proclamation recognized all three campuses of the CSU System for educating nearly 60,000 students every year, generating more than $465 million in annual economic activity, and improving the lives of all Colorado citizens.

By lunch time, the Fort Collins campus was ready to party, first with selfies with the larger-than-life #csu150 on the Plaza, then with cake and cookies and 150th items at The Foundry in the Corbett/Parmelee dining center. CAM the Ram, CSU Cheer and the Pep Band provided the excitement while people signed the giant birthday card.

And the events werent over yet. Tuesday evening, former UN Ambassador Susan Rice sat down for a conversation with NPR foreign correspondent Greg Myre. The free talk, sponsored by the Office of International Programs with generous support from Women and Philanthropy and the Provosts Sesquicentennial Colloquium, filled the Lory Student Center Ballroom. She talked about her early life her mother is widely considered the mother of the Pell Grant that provided college opportunity for low-income students as well as other topics covered in her new book, Tough Love.

Rice could have been summing up CSUs 150 years of education, research and service to the people of Colorado and the world with this observation:

The more we know each other the more we engage each other and recognize each other as human beings the better, because, for better or for worse, we are all in this together and we are going to sink or swim together.

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Different contexts, similar missions: Dr. Sarah Naramore blends interests in biology and history through her academic expertise – The Sewanee Purple

February 12th, 2020 11:47 pm

Dr. Sarah Naramore in her office. Photo by Robert Mohr (C21).

By Luke GairExecutive Staff

For about three weeks of her undergraduate career, Visiting Assistant Professor of History Dr. Sarah Naramore intended to pursue veterinary medicine. Her history minor, which would eventually become her lifes work, was at first an attempt to stick out as an applicant to competitive veterinary schools.

Im not proud of thinking that way, but it was true of me as an eighteen-year-old, Naramore laughed. Biological and ecological research loomed at the forefront of her work in college but, as she became more attuned to her interests, she realized that the larger, messier questions she kept finding herself asking were more logically suited to the humanities instead.

Rather than a traditional history class steering her toward academia, it was instead mycology that allowed her the revelation necessary to begin her present career path. After she was tasked to research claviceps purpurea, a fungus most notably known for its effects on cereal plants, her two seemingly disparate interests bloomed into a single field of study. In the midst of her research, it became strikingly clear just how braided the scientific and historical are with one another. Thus, the double major in history and biology was declared.

It was the first time I really thought how the biological world has impacted history, she began. I didnt really know the history of medicine or science was a thing until I started putting it together in this class. It sort of clicked, and I thought This is what I want to do, I want to see how this messy biological and ecological world has shaped human activities.

A career in veterinary medicine might be in the rear view mirror for Naramore, but an intersection between her past and present career paths is unyielding: [History and biology] are inherently interested in how both are bringing high understanding of science into different contexts. Rather than a separate entity, she sees doctors as comparable to engineers or scientists, ones who are trying to apply basic science to varying biological and social contexts.

This philosophy greatly manifests in her forthcoming book entitled Medical Independence: How Benjamin Rush Created Medicine, 1780 to 1813, where she argues and explores how the practice of medicine, biological theory, and political theory converge in previously unrealized ways. The work derives from her doctoral dissertation, I Sing the Body Republic: How Benjamin Rush Created American Medicine.

The clever, Whitman-inspired title was changed in the publishing process in order to reach a broader audience [rather than] a four-person thesis committee.

Naramore defended her thesis in April of 2018 and then formally graduated as a PhD student from the University of Notre Dame in August of that same year. Less than a month later, she began teaching her first college classes.

As an alumna of a liberal arts college herself, Naramore was already familiar with the core mechanics of the classroom at such institutions like smaller class sizes, but that doesnt necessarily mean that adaptation wasnt needed.

The first semester of being here was a lot like being thrown in, she noted. With three courses to plan and prepare for, things werent slowing down for the recently arrived professor any time soon. It was great, but it was all at once.

In classes where non-major students are enrolled, especially those introductory level courses, Naramore shared her enthusiasm in approaching those unfamiliar with the course material. In a community like Sewanee where were trying to break down those silos between disciplines, she remarked, theres something to be said about getting fresh perspectives and talking out your ideas with students who are new to these ideas.

Naramore sees the classroom as grounds for conversation rather than simple lecturing, and she underlined such a belief through clarifying that studying history in higher education is less about memorization. Alternatively, it introduces students and scholars to nuanced disciplines and ways of thinking. With the internet at our fingertips, its crucial to understand and process the information we read, so studying history grants such critical thinking skills.

Im interested in how we get from this expansive view to having these very narrow, professional boxes. Im influenced by the idea of American medical exceptionalism, she concluded. I think theres some resonance in understanding how Americans can of themselves as exceptional, and how an interpretation of biology can get us there.

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Continuing a Legacy of Love and Care | News – Winchester News Gazette

February 12th, 2020 11:47 pm

Pet owners near Parker City may have noticed a few changes lately at Parker Veterinary Service. They need not worry though as Dr. Daniel Hendrickson plans to continue the legacy that Dr. Kenneth Stites began nearly 50 years ago providing the same loving care to local pets as his predecessor as well as expanding and improving many of the services that they provide. We strive to provide the best quality care possible at affordable prices, states his wife Telynda.

Over the years, Dr. Stites had numerous partners in his practice, in his small office next door to H & R Block on Highway 32, one of these was Daniels uncle, long-time area veterinarian Dr. Dale Hendrickson, who retired and turned the large swine operation South of Parker City over to his nephew about 5 years ago. Dr. Stites found it quite fitting that Daniel would be the one to buy his practice, as the Hendrickson family has practiced veterinary medicine in the area for decades.

Hendrickson likes to keep things local. All of our staff live within twenty miles of the office, says Telynda. We also try to support the community by buying our supplies as locally as possible, she adds.

As one enters the new office, just down the street, next door to the City Building, you cant help but notice the numerous photos of dogs and cats decorating the walls. We had a photo contest for some of our clients, she explains. This was our winner, she says gesturing to a photo of a Dalmation sitting on a firetruck. We try to keep things as calm and quiet to keep things as stress-free as possible for the animals, she adds noting that they have separate kennel areas for dogs and cats who are recovering from surgery or other treatments. We also have rooms so that we can isolate any aggressive animals that are brought in, she notes.

We are a walk-in clinic dealing with primarily dogs and cats. We also take appointments. We have treated other small mammals, like rabbits and hamsters, in emergency situations, but we focus on dogs and cats. If you have something a bit more exotic, say a bird or a reptile, well gladly refer you to someone who can provide treatment for your pet, She continues.

We have two exam rooms and are equipped to do full dental exams as well. We also have an on-site lab where we can do blood work. Most local practices have to send their blood work to a lab and wait for the results to be sent back to them, she explains. We are very open and allow owners to remain with their pets for as much of the visit as possible, she goes on. Another service that people may not be aware of is our private crematorium operated by a retired EMT who is very passionate and takes great care in his work, staying with the remains throughout the process and ensuring that they are returned to the owner, she adds.

Parker Veterinary Service is also progressing into the digital age. The practice has converted all of its records over to a digital format. Within the next few weeks pet owners will be able to use Care Credit to pay for their pets treatments. The practice will also have an online store where clients can order medicine and supplies and have them shipped directly to their homes. We also have a huge following on Facebook, noted Hendrickson.

As I continued my visit, I was introduced to two of the Veterinarians on staff. Dr. Maggie Thornburg has 27 years experience and has a real talent for dealing with cats. Cats respond well to her, explains Hendrickson. The practice recently added Dr. Lindsey Pritchard to their staff. She greeted me saying, I would shake your hand, but Ive got honey on mine. She was trying to save a kitten that had been found in a shed earlier that cold morning by some workers who brought it in to the office. Im feeding her honey and keeping her warm. Hopefully, shell pull through, she commented.

We would like to thank the community for their support and for helping to make the transition go as smoothly as possible, says Hendrickson. We hope to continue the legacy of Dr. Stites by providing the best possible care for area pets at a very reasonable rate, she adds. Parker Veterinary Service has an extremely compassionate, caring, and knowledgable staff. Area pet owners can rest assured that their furry little friends will receive the best of care in their more than capable hands.

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Parkinson’s driven by inflammation, genetics and the environment – UAB News

February 12th, 2020 11:46 pm

Written by Jesse Saffron, Ph.D., National Institute of Environmental Health Sciences. Used by permission

The reality is that today, we still dont have a treatment that slows or alters the progression ofParkinsons disease, saidDavid Standaert, M.D., Ph.D.

In 1817, James Parkinson published An Essay on the Shaking Palsy, describing the disease that now bears his surname. The British surgeons proposed treatment bloodletting proved ineffective, and the intervening two centuries led to no breakthroughs for patients.

The reality is that today, we still dont have a treatment that slows or alters the progression ofParkinsons disease, saidDavid Standaert, M.D., Ph.D., during a Jan. 8 talk at the National Institute of Environmental Health Sciences. He is chair of the Department of Neurology at the University of Alabama at Birmingham. We can help patients function better, but were not changing the underlying nature of the disease.

Parkinsons disease is complex, involvinggenetic and environmental factors, and their interaction.Guohong Cui, M.D., Ph.D., head of the NIEHS In Vivo Neurobiology Group, invited Standaert to discuss the role immunity plays in the disorder. Both researchers seek to discover ways to slow advancement of the condition and make it less severe.

Dr. Standaert is an established researcher in the Parkinsons field, which is one of the major areas my lab works in, Cui said. His team examines how pesticides interact with genetic factors associated with the disease and ways to slow dopamine loss, which is a hallmark of the disorder.

At UAB, Standaert directs the Morris K. Udall Center of Excellence in Parkinsons Disease Research, one of eight such centers funded by theNational Institute of Neurological Disorders and Stroke. One of his research questions is whether immune system responses to a protein called alpha-synuclein trigger neurodegeneration.

Alpha-synuclein is a cornerstone of research in Parkinsons disease, Standaert told the audience. It is a small protein present in high levels in neurons throughout the brain. It participates in virtually every form of the disease, whether through mutation, overexpression or aggregation, which is probably the most common mechanism.

Abnormal forms of alpha-synuclein may activate immune cells in the brain, leading to inflammation that drives progression of the disorder.

For many years, it was said that this is a degenerative disease and cells are dying, so, of course, theres inflammation, he said. I think in the last few years, weve turned this around and realized that the inflammation may come first, as part of a process that leads to degeneration.

When mutated, the LRRK2 protein can worsen problems caused by alpha-synuclein. It is one of the most common genetic causes of Parkinsons. In our clinic, about 2 to 3 percent of patients have LRRK2 mutations, he noted. Those mutations may cause Parkinsons by cranking up sensitivity of the immune system they may increase the magnitude of the response to alpha-synuclein.

But other factors bear consideration. To study the mechanisms responsible for Parkinsons disease, there is a need for model systems that replicate the effects of environmental toxins, Standaert said. He highlighted research by NIEHS grantee Briana De Miranda, Ph.D., of the University of Pittsburgh. She studies, among other things, how organic solvents may boost susceptibility to Parkinsons disease in individuals with LRRK2 mutations.

Standaert says the fact that inflammation may cause the disorder to advance more than it otherwise would means that anti-inflammatory drugs could hold promise. We have immunologic treatments for a lot of other diseases, such as inflammatory bowel disease, psoriasis and multiple sclerosis, Standaert said in an interview. Could we use one of those or something similar in Parkinsons disease to slow its progression?

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The Illusion of Genetic Romance – Scientific American

February 12th, 2020 11:46 pm

Genetic matchmaking is entering the mainstream. The prospect of meeting and selecting potential romantic partners based upon purported DNA compatibilityuntil very recently the subject of science fiction from films like The Perfect 46 to independently published romances by Clarissa Lakehas increasingly garnered both scientific and commercial attention. Earlier this year, Nozze, a well-established Japanese dating service, established a DNA Matching Course and hosted a related DNA Matching Party, both first-time offerings in that nation. For 86,400 yen ($790), men are paired with prospective dates based upon 16,000 variations in HLA gene complexes.

Nozze joins a market commercializing the science of attraction that already includes Swiss pioneer GenePartner, Houston-based Pheramor and services that combine genetic and non-genetic profiles like Instant Chemistry and SingldOut. Considerable media attention has been devoted to investigating the science behind these services; unfortunately, both the ethical and sociological implications have received relatively short shrift.

The underlying science itself is hardly convincing. Since the 1970s, researchers have found that variations in the genes of the major histocompatability complex (MHC) play a role in mate selection in mice. Similar patterns have subsequently been found in fish, pheasants and bats, but not in sheep. The possibility that MHC plays a role in human mate selection first arose as a result of a well-known experiment by Swiss biologist Claus Wedekind that is colloquially known as the sweaty T-shirt study. Researchers had men wear T-shirts for extended periods of time before placing the shirts in boxes; then they had women sniff the shirts to rate the former wearers sexual attractiveness. They found an inverse correlation between MHC similarity and attraction score.

Since that time, studies in human beings have yielded mixed results. The most persuasive data come from an investigation of Hutterite couples in North America who appear to display nonrandom MHC assorted mating preferences. But this correlationgiving genetic matchmaking the benefit of the doubtestablishes at most a natural preference, and a natural preference is a far cry from connubial compatibility. To our knowledge, nobody has actually surveyed married Hutterite couples to determine whether MHC compatibility plays a role in their levels of marital bliss, or the quality of their dinner conversation, or the frequency of their escapades between the sheets. On a more global scale, no data have yet established a relationship between MHC compatibility and lower divorce rates.

One must ask precisely what we mean by compatibility. At the most fundamental level, couples with MHC-dissimilarity (and thus more so-called mating compatibility) demonstrate lower rates of spontaneous abortion. The dissimilarity may also increase genetic polymorphism, which in turn may lower the manifestation of recessive diseases. However, the impact of MHC-dissimilarity on either of these phenomena is likely to prove relatively small, and therefore should not be expected to play a significant role in the marital happiness or cohesion of many couples.

In addition, genetic polymorphism may help species survive environmental challengesyet evolutionary advantage is probably not a major variable that most couples consider when seeking romantic bliss. One cannot also ignore the unknowns: Matching couples based on MHC markers may pose some survival benefits, but nobody knows at what cost; it is theoretically possible that the offspring of such couples are also more aggressive or less creative, just to name two traits arbitrarilyand magnifying these effects artificially might prove significantly deleterious to our civilization in the long run.

Harvard geneticist George Church has championed another version of compatibility. Using whole genome sequencing, he hopes to match couples so as to reduce or eliminate many recessively inherited diseases. In Ashkenazi populations, the Committee for Prevention of Jewish Genetic Diseases (better known as Dor Yeshorim) already uses a voluntary testing and matching system to prevent disorders such as Tay-Sachs, Canavan and Niemann-Pick. Church hopes to implement a variation of this program for couples everywhere, claiming it could end some 7,000 genetic diseases and save 50 million lives a year.

The ethical implications of Churchs proposal are complex. If couples are encouraged to use his pairing system, then those who find love outside the realm of genetic matchmaking and produce offspring with genetic disorders may be unfairly stigmatized. At a more practical level, even if the elimination of recessive illnesses is a social good, it is clearly not the sort of compatibility most daters seek in a matchmaking service.

When most people speak of romantic compatibility, the odds are that they mean factors like temperament, tastes and interests. To date, no study has connected these with any genetic variable. MHC-dissimilarity is as likely to lead to partners with temperamental and aesthetic difference as to those with similarities. Ironically, even compatibility appears to have minimal impact on satisfaction in relationships. Multiple studies have shown that universal traits such as kindness, rather than similarities, are the keys to marital happiness.

Genetic matchmaking reflects two concerning trends in modern society. The first is the pandemic loneliness and search for connection that has arisen in the wake of the breakdown of traditional community structures. To use a metaphor first introduced by political scientist Robert Putnam, we are a society bowling alone. We are increasingly willing to shell out a few hundred dollars or a few thousand yen for anything that smacks of a cure.

Genetic matchmaking also manifests the misguided belief that science can solve all of our problems. Unfortunately, we cannot discover, pay or invent our way out of our isolation. Science may ultimately provide tools that help us rebuild societal cohesion, but without meaningful changes in social policy and human behavior, science alone has little to offer. In this case, the science in question is, at best, being misusedand arguably not science at all.

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Layoffs at genetic testing companies reflect the changing market – The Verge

February 12th, 2020 11:46 pm

At-home DNA testing companies 23andMe and Ancestry each laid off about 100 employees over the past month, cutting around 14 and 6 percent of their workforces, respectively.

23andMe pointed to declining sales as the reasons for the layoffs, and Ancestry CEO Margo Georgiadis cited a slowdown in demand across the entire DNA category in a blog post. Interest in DNA testing skyrocketed through 2016, 2017, and 2018, with millions of people buying kits from direct-to-consumer companies. But in 2019, interest started to wane Illumina, which makes products used by these companies, said that the market was weak.

Thats probably because the market is saturated, and most people who would want to buy a DNA test kit already have, says David Mittelman, founder and CEO of the forensic genomics company Othram and former chief scientist at Family Tree DNA. That market is a certain size, and its being tapped out, he says.

It may also just be that all of the early adopters have bought and used DNA testing kits, says Shawn Baker, a genomics consultant and former scientist and manager at Illumina. They need to broaden out past the early adopters to everyone else, he says.

Compounding the problem, the service doesnt lend itself to repeat customers. You get tested once and youre done, Baker says. Theres also no real reason for users to return to the platform, except to see if any previously unknown or distant relatives have joined the service. But even then, the companies dont see additional revenue.

23andMe CEO Anne Wojcicki speculated that genetic privacy concerns could be one reason for the dip in sales. But Mittleman doesnt think that plays a big role. Im sure some people are worried about privacy, he says. I think people are burned by privacy more with Facebook than with genetic testing. Thats what they worry about.

23andMe and Ancestry did not respond to an emailed request for comment.

Ancestrys growth was also linked to their advertising spending they spent over $100 million on television ads in 2016, for example. Their growth was proportional to their spending, but thats since plateaued, Mittelman says. Acquiring more customers, who arent already inclined to be interested in existing products, would be expensive, he says.

But bringing in more customers for personal testing kits may no longer be the priority at these companies: instead, theyre turning their focus towards health. Ancestry says its shifting focus towards Ancestry Health, and plans to introduce new products that give customers information about their health risks. 23andMe plans to concentrate its research on a drug development arm, which has already proven lucrative: it started partnering with pharmaceutical companies in 2018, and in January, the company sold the rights to a drug it developed in-house.

The companies may want to keep pulling in customers to bolster their databases of genetic information, Baker says. Subscriber growth matters in terms of how good that database is.

But over the past few years, both companies have built up their databases of genetic data, and they may already be large enough to answer health care questions. These databases only need so much information before they can be useful to researchers and drug developers. If theyve reached that point, and it will take expensive marketing and advertising to pull in new customers, it might not be worth the investment to try and expand the pool, Mittelman says.

From the outside, that seems to be what the situation is, he says. You dont see 23andMe running sales trying to get people on board. Its not the priority.

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Accessing the World of Genetics – Stock Investor

February 12th, 2020 11:46 pm

As to diseases, make a habit of two things to help, or at least, to do no harm.

Hippocrates

The increasing ability of human beings to treat formerly lethal diseases has had a massive effect on the quality of our lives over the past century. However, many damaging genetic diseases such as Tay-Sachs and cystic fibrosis have remained outside of this pattern.

While certain drugs and treatments for these conditions do exist, they only can ameliorate the symptoms, not cure them.

Yet, the fact that the genomics industry is working to remedy this situation by developing gene-editing tools like CRISPR also provides new opportunities for investors. For instance, the ARK Genomic Revolution ETF (BATS: ARKG) provides investors with exposure to companies around the world that are involved in the genomics revolution, regardless of sector.

As of right now, most of its holdings are in U.S health care companies, most of which (71.93%) are in the biotech sector. Its other top sectors include advanced medical equipment and technology (12%), medical equipment, supplies and distribution (6.49%), health care facilities & services (4.21%) and pharmaceuticals (4.13%).

Its top holdings include Invitae Corp. (NYSE: NVTA), Illumina, Inc. (NASDAQ: ILMN), CRISPR Therapeutics AG (NASDAQ: CRSP), Intellia Therapeutics, Inc. (NASDAQ: NTLA), Compugen Ltd. (NASDAQ: CGEN), Editas Medicine, Inc. (NASDAQ: EDIT) and Teladoc Health, Inc. (NYSE: TDOC).

This funds performance has been solid in both the short run and the long run. As of February 10, 2020, ARKG is up 4.70% over the past month and up 19.95% over the past three months. It currently is up 6.59% year to date.

The fund currently has $514.19 million assets under management and an expense ratio of 0.75%, meaning that it is more expensive to hold in comparison to other ETFs.

Chart courtesy of http://www.StockCharts.com

While ARKG does provide an investor with a chance to profit from the world of genetics, the sector may not be appropriate for all portfolios. Interested investors always should conduct their due diligence and decide whether the fund is suitable for their investing goals.

As always, I am happy to answer any of your questions about ETFs, so do not hesitate to send me an email. You just may see your question answered in a future ETF Talk.

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The last woolly mammoths on Earth had disastrous DNA – Livescience.com

February 12th, 2020 11:46 pm

Dwarf woolly mammoths that lived on Siberia's Wrangel Island until about 4,000 years ago were plagued by genetic problems, carrying DNA that increased their risk of diabetes, developmental defects and low sperm count, a new study finds.

These mammoths couldn't even smell flowers, the researchers reported.

"I have never been to Wrangel Island, but I am told by people who have that in the springtime, it's just basically covered in flowers," study lead researcher Vincent Lynch, an assistant professor of biological sciences at the University at Buffalo in New York, told Live Science. "[The mammoths] probably couldn't smell any of that."

Related: Mammoth resurrection: 11 hurdles to bringing back an ice age beast

Wrangel Island is a peculiarity. The vast majority of woolly mammoths died out at the end of the last ice age, about 10,500 years ago. But because of rising sea levels, a population of woolly mammoths became trapped on Wrangel Island and continued living there until their demise about 3,700 years ago. This population was so isolated and so small that it didn't have much genetic diversity, the researchers wrote in the new study.

Without genetic diversity, harmful genetic mutations likely accumulated as these woolly mammoths inbred, and this "may have contributed to their extinction," the researchers wrote in the study.

The team made the discovery by comparing the DNA of one Wrangel Island mammoth to that of three Asian elephants and two other woolly mammoths that lived in larger populations on the mainland.

"We were lucky in that someone had already sequenced the [Wrangel mammoth's] genome," Lynch said. "So, we just went to a database and downloaded it."

After comparing the mammoths' and elephants' genomes, the researchers found several genetic mutations that were unique to the Wrangel Island population. The team had a company synthesize these tweaked genes; then, the researchers popped those genes into elephant cells in petri dishes. These experiments allowed the researchers to analyze whether the proteins expressed by the Wrangel Island mammoth's genes carried out their duties correctly, by sending the right signals, for instance, in the elephant cells.

The team tested genes involved in neurological development, male fertility, insulin signaling and sense of smell. In a nutshell, the Wrangel Island mammoths were not very healthy, the researchers found, as none of those genes carried out their tasks correctly.

That said, the study looked at only one Wrangel Island mammoth, so it's possible that this individual's comrades didn't have similar genes. But "it's probably unlikely that it was just this one individual that had these defects," Lynch said.

In fact, the case of the Wrangel Island mammoths is a cautionary tale about what can happen to a population that is too small and therefore lacks genetic diversity, he said.

The findings build on those from a study published in 2017 in the journal PLOS Genetics that found that the Wrangel Island mammoth population was accumulating damaging mutations.

The new study was published online Feb. 7 in the journal Genome Biology and Evolution.

Originally published on Live Science.

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How to turn racists genetic arguments against them – The Irish Times

February 12th, 2020 11:46 pm

It was funny once. The perfectly square bit of dirt on the window. The shocked reactions of Craggy Islands Chinese community. The local farmer who doesnt have much time to be a racist, because he just likes to have a cup of tea in the evening. The feckin Greeks

Dermot Morgans finest televisual moment that evocation of Nazi speech-making in front of the greatest window in comedy is perhaps a little less funny now that prime minsters or presidents of Hungary, Turkey, the United Kingdom and the United States are happy and comfortable to spout racist statements, and not merely get away with it but be applauded for it by their supporters.

How have we reached this point? Its the very question asked by geneticist and broadcaster Dr Adam Rutherford. Hes the Rutherford in the BBCs popular radio programme The Curious Cases of Rutherford and Fry, in which he and Dr Hannah Fry try to solve listeners scientific queries.

In the case of the resurgence of publicly acceptable racism, Rutherford decided that a radio show was insufficient and that a book would be needed. How to Argue with a Racist is published this week, and Rutherford will be delivering a lecture on the subject during the Northern Ireland Science Festival.

So, how did we get back here? I find myself asking the same question, Rutherford says. I find myself in lectures thinking how strange it is that Im now talking about this, because these are mostly questions that were parked, in my field genetics years ago. Maybe decades ago. And we keep discovering interesting things about evolution and population differences, and migration, and so on, but the question of how race as a concept relates to biological diversity, that ended a while back.

Having these conversations in the academy is one thing, but as someone who tries to communicate science, to talk about it, as a broadcaster and as a writer, I found I was suddenly having very different conversations. Conversations about race, when we were talking about ancestry In some ways, science has failed to convey to the public what is correct, and so I want to equip people with what current scientific thinking is, so that when the question comes up, they have the tools to respond. To say, Yes, there hasnt been a white man in the Olympic 100m final since 1980, but no thats not because of any lack of African-American ancestry.

Its precisely that sort of casual, inauspicious racism that Rutherford looks to quash with his book. The idea that Olympic athletes with African heritage are somehow better because their genes are imbued with extra strength is rubbish, he says. For a kick-off, using athletes as a test sample is a daft idea because anyone with the sort of genetic gifts that allow them to perform at the highest level is a poor sample of what a broader population is like. Beyond that, theres a simpler rebuttal if those with African heritage are inherently genetically better at running very quickly than others, then where are the Olympic 100m champions from South America, Europe or elsewhere with populations that can trace heritage to Africa?

Besides, tracing your genetic lineage in that manner, looking for secrets and answers to why you are so underprivileged compared with others, is a nonsense, says Rutherford. I do think that part of the change in culture which means I kind of had to write this book is to do with the rise of nationalism and the more open discussion of race. Certainly there are more open discussions of public racism than at any point I can remember in my lifetime. There are other factors, though, such as the rise in genetic ancestry testing kits. Now, theyre not pernicious in themselves, but I argue that they have fostered a misunderstanding of what genetics means, and specifically in the form of a sort of reversion to essentialism. So a notion that were determined by our genes and our ancestry, which as a geneticist I just dont think are scientifically valid nor verifiable to the extent that people adopt them.

So, when you take one of these tests and it comes back saying that youre 10 per cent Swedish, or 15 per cent Irish, these are very broad strokes, that are not scientifically meaningless, but they are of only trivial relevance. But people attribute very great significance to them. For instance, I sometimes talk about the fact that, genetically speaking, there is no such coherent ancestral group as Celts. But try telling that to an audience in Glasgow and see what happens.

Over in Ireland youve got some of the best genetic genealogists in the world, people like Dan Bradley [head of the school of genetics at Trinity College Dublin] who has been tracking the story of the Irish for years, and thats really important work, its important to understand the movement of peoples and the migration of peoples. But theyre always complex. Ancestry is a matted web, not linear family trees.

For example, I have a friend who told me that hes descended from Niall of the Nine Hostages, and they can trace their ancestry back to him. Well, theres two things about that. One, no one is actually really sure if Niall of the Nine Hostages existed, which is problematic for a starter.

The second thing, though, is that if he did exist, he lived in the fourth or fifth century, and thats a date which comes before the isopoint, which is the time at which everyone in Europe is descended from everyone else. So if Niall did exist, and if my friend Bill is directly descended from him, then so too am I. And so are you. And so is a guy in southern Italy, and in Turkey, and literally everyone else in Europe. So if you can attach some kind of tribal identity to that, that idea that youre descended from some fifth-century Irish king, well everyone else is too.

This is a relatively recent revelation. One that has the power to stun those who claim kinship with any royal lineage, or who might have notions of racial purity. The simple, genetic, fact is that your family tree isnt a neat family tree at all. Its more like an overgrown shrub, especially the farther back you go. And because everyone elses is, too, it means that the family shrubs intertwine and merge until, once you go back a surprisingly few generations, were all related to everyone else.

Thus the late actor Christopher Lees claim to be directly descended from Charlemagne is accurate, but also meaningless. Not everyone can prove it using family trees. Christopher Lee could, because he was the descendent of an Italian contessa, so they had the paper trail of her family going back. The whole Danny Dyer story, which showed that he was a direct descendent of Edward III, they were able to paper-trail that too, and very few people can actually do that, but I calculated out a mathematical proof that anyone with long-standing English heritage is also 100 per cent descended from Edward III.

At which point I suggest that we should use our now undisputed and mathematically proven royal lineage to, shall we say, take back control, but Rutherford politely declines my invitation to insurrection. The point is, of course, more profound than working out where you stand in line for a throne. Its the fact that every white supremacist has, if you trace their genetic code back, African ancestry. Every Nazi has Jewish heritage. Every Briton is a mish-mash of European bloodlines.

The problem, of course, is that while all of this science is correct and provable, its also useless in the face of racism. As someone once said: You can argue with a racist; you can argue with a Labrador retriever, too, for all the good it will do you.

Rutherford agrees, but says theres a more important battle, on two fronts, to be fought. Part of the book discusses actual neo-Nazis and white supremacists, because they are obsessed with genetics. And their misunderstanding of genetics makes them think that they can prove some sort of racial purity, which is a nonsense. Arguing with those guys using science is a demonstration of the old Jonathan Swift maxim that you cant reason someone out of a position that they didnt reason themselves into, he says.

Who Im really interested in reaching, though, are those who arent racists, and who dont think like that. But because of relying on stereotypes, or myths, or the cultural sphere that says that race is real, or that some factors are biologically encoded and that those factors segregate by race, I want those discussions to be the ones that are informed by science. Because those people arent fundamentally racist, so when youre armed with facts, and youre armed with a knowledge of history, then I think that is your best route to change. Science is a powerful ally, its the best ally we have, I think. But whats the Bob Dylan line? I know my song well before I start singing.

One of the ideas I explore is that scientists need to get more involved. Its no longer good enough to simply say: Heres the data and let society decide. Racists have no such compunctions, and will use every tool at their disposal to spread their message. So if we. as scientists, sit back and say, Hey, its just the data and I dont know what the political ramifications are, thats for others to discuss, then were volunteering ourselves to defeat, and for our voices to be silenced in favour of populist, emotive arguments, and thats the political landscape in which we now live.

Racism isnt wrong because its drawn from and based on a misunderstanding, or specious scientific ideas. Racism is wrong because its an affront to basic human dignity. What Im saying is, if you want to be a racist, fine, fill your boots, go ahead, but you cant have my scientific tools, my weapons, to justify your position.

How to Argue with a Racist by Adam Rutherford is published by Orion. Northern Ireland Science Festival runs February 13th-23rd. nisciencefestival.com

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Mexico: Feed prices allow for production growth, genetic focus – FeedNavigator.com

February 12th, 2020 11:46 pm

The US Department of Agriculture (USDA) released new information regarding feed use and livestock production in Mexico in a report from the Foreign Agricultural Service (FAS) on Friday.

Increasing livestock production in Mexico has been supported by the movement toward vertical integration in production and improved biosecurity, the FAS reported. Stable feed prices and better zoo-sanitary conditions suggest that the expansion will continue.

Feed price consistency has allowed livestock breeders to seek better genetics, the agency said.

Feed prices did slightly fluctuate in the last two quarters of 2019, but industry expects overall grain and feed price stability to prevail through 2020, the agency said. The stability in feed prices as well as steady domestic livestock prices allow producers to focus their operations more on breeding than slaughtering.

In marketing year (MY) 2020, beef production is expected to reach 2.1m metric tons (MT) and consumption is expected to reach 1.9m MT, the FAS said. Industry growth from 2015 through 2019 averaged about 2% annually, despite changes in prices for feed and grains.

The Mexican beef industry has kept a steady pace of investments, adaption of new and improved production practices, as well as improved technology to stimulate the beef production sector, the agency said.

Swine production in MY 2020 is anticipated to be a 20.3m head based on increasing consumer demand and supported by vertical integration of producers, the agency said. Pork production is forecast to reach 1.47m MT.

According to industry studies, pork consumption has increased as a share of domestic consumption from 28% to close to 32%, with poultry retaining the biggest share at over 60%, the agency said.

During the 2018-19 export cycle, Mexicos exports of cattle to the US reached 1.313m animals an increase of 17.6% from the previous year, the FAS said. Trade has been valued at more than $760m.

Trade is expected to continue expanding, if more slowly, during MY 2020, the agency said.

A pilot program has been established to regulate trade and improve zoo-sanitary status in live cattle coming in from Guatemala, the agency said. The agreement emphasizes that cattle to be exported from Guatemala will come from ranches certified by the Ministry of Agriculture of Guatemala (MAGA) as free of bovine tuberculosis and brucellosis, which will be tagged with the Central American Electronic Earring and utilizes radio reference technology.

Personnel from MAGA and the International Regional Agency for Agricultural Health (OIRSA) will verify the fulfillment of a 21-day quarantine of cattle at the ranch of origin or in the feedlots constituted for it, FAS said. Currently, 70 ranches in Guatemala have been certified, and the program is set to run through November 2024.

Beef imports in MY 2020 are expected to increase to 212,000 MT, the agency said. The United States remain the main beef provider to Mexico with 86% market share, followed by Canada with 7.5%, and Nicaragua with 4.7%.

Exports of beef in MY 2020 are forecast to increase by 10% and reach 347,000 MT, the FAS said. Expanding the use of feedlot-based production is one factor supporting the increased exports.

Japan is consolidated as the second most important export market for Mexican beef, comprising 7% of Mexicos beef exports, followed by Hong Kong with 4%, the agency said. For many years, South Korea was the third most important Mexican beef export destination, but now holds the fourth position with 2% of market share.

On the swine side, the forecast for MY 2020 calls for live hog imports of 41,000 head and pork imports of 1m MT, the agency said. Mexico is dependent on imports to meet domestic demand, but imports have been slow based on the countrys economy.

In MY 2020, imports will rise compared to their low in 2019, as pork consumption continues its positive trend and growing exports to China compete with domestic consumption, the FAS reported.Mexico will resume imports from the United States in order to satisfy the domestic demand.

Pork exports are predicted to reach a record 250,000 MT as Mexico focuses on supplying Asian markets, the agency said.

Mexican pork exports have grown considerably through 2019, especially to Japan, the agency said.The trend will continue as the industry is expecting an important growth of exports for 2020, especially to China.

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ABCA7 Gene Expression and Genetic Association Study in Schizophrenia | NDT – Dove Medical Press

February 12th, 2020 11:46 pm

Kiyohiro Yamazaki,1 Yuta Yoshino,1 Kentaro Kawabe,1 Tomomasa Ibuki,1 Shinichiro Ochi,1 Yoko Mori,1 Yuki Ozaki,1 Shusuke Numata,2 Jun-ichi Iga,1 Tetsuro Ohmori,2 Shu-ichi Ueno1

1Department of Neuropsychiatry, Molecules and Function, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan; 2Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima 770-8503, Japan

Correspondence: Jun-ichi IgaDepartment of Neuropsychiatry, Molecules and Function, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, JapanTel +81-89-960-5315Fax +81-89-960-5317Email iga.junichi.it@ehime-u.ac.jp

Introduction: Although ATP-binding cassette sub-family A member 7 gene (ABCA7) is known to be associated with Alzheimers disease, the relationship between ABCA7 and schizophrenia has been unknown.Methods: Schizophrenia patients (n = 50; 24 males, 62.1 0.50 years old) and age- and sex-matched healthy controls (n = 50) were recruited for the mRNA analysis. Additionally, a case-control study for the rs3764650 genotypes was performed with 1308 samples (control subjects; n = 527, schizophrenia patients; n = 781). All participants were Japanese, unrelated to each other, and living in the same area.Results: The distributions of the rs3764650 genotypes in schizophrenia patients were not different from that of controls. However, the ABCA7 mRNA expression levels in schizophrenia patients were significantly higher than those in controls by a logistic regression analysis. Additionally, the ABCA7 mRNA expression levels in schizophrenia patients were correlated with the rs3764650 genotypes in a dose-dependent manner.Discussion: The ABCA7 mRNA expression levels in peripheral blood with the rs3764650 genotypes may be related to pathological mechanisms in schizophrenia and may be a biological marker for schizophrenia.

Keywords: schizophrenia, ATP-binding cassette sub-family A member 7 gene, single nucleotide polymorphism, rs3764650, mRNA expression

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Amyloid, Tau Buildup in AD Spur Gene Expression that Causes Brain Inflammation – Clinical OMICs News

February 12th, 2020 11:46 pm

New research from the UK has revealed that the build-up of proteins in neuronal cellsthe hallmark of Alzheimers diseasemight be affecting the activity of genes implicated in the disease. This novel discovery may help shed more light on how and why these proteins build up, and how they lead to neuronal death and destruction.

Currently, no treatments are available that can change the course of Alzheimers disease. [This new information can be used to help scientists in their] understanding the interaction between genes and progression of the disease, said Prof. Jonathan Mill, of the University of Exeter Medical School, who led the project.[It] will help us identify new targets for treatment, which we hope will one day lead to drugs that can effectively treat this terrible disease.

Alzheimers disease is a disease of the elderly, commonly associated with loss of memory as it progressives, and eventual loss of all cognitive function. How it develops is not a well understood process, but it is suspected that genetics play a role. The tale-tell histological confirmation of Alzheimers disease is the presence of amyloid plaques and neurofibrillary tangles (made up of the protein tau)each the product of normal proteins which become over-expressed in diseased neuronal brain tissue to the point the neurons are poisoned and die. These proteins are found in lower amounts in normal brains, and the number of plaques and tangles found in patients tends to correspond to the severity of the disease phenotype.

Researchers at the University of Exeter, working in collaboration with Eli Lilly, and funded by Alzheimers Research UK and Alzheimers Society, have examined the brains of mice with mutations in the genes that code for amyloid and tau proteins, hoping to build an animal model to understand the disease better. The build-up of both proteins in specific regions of the brain is known to play a role in Alzheimers disease, so by recreating the genetic conditions, they hope to be able to determine what else must occur for disease development.

The results of this study were published inCell Reports, and the researchers found evidence that the levels of gene activity changed dramatically as tau and amyloid accumulated in the brain. The team also observed significant changes in the levels of gene expression involved with regulating inflammation through the immune system, which became more active as tau levels increased. The research also found new pathways potentially involved in the progression of Alzheimers disease, which adds weight to theories of brain inflammation being a key component in the build-up of tau.

First author Dr. Isabel Castanho, of the University of Exeter, said: Our results suggest that the genes which are disrupted through the build-up of tau and amyloid in the entorhinal cortex region of the brain influence the function of the immune response in the brain, which is known to be a key component of Alzheimers disease.

The team monitored the build-up of both proteins in the brain and the expression levels of their corresponding genes as the mutant mice aged, so they could track the same corresponding time associated in humans with disease worsening. The sequence of events is believed to be similar in the model organism.

Castanho and her team observed the expected build-up of both tau and amyloid, and noted that these changes corresponded to widespread changes in gene expression particularly in the case of tau.

This new information suggests that the accumulation of tau might have a more dramatic effect on gene regulation in the brain than amyloid. Furthermore, several genes observed to be upregulated in this experiment are also known risk factors for Alzheimers disease, and the overall changes observed in the mutant mice mirrored those seen in human Alzheimers disease brains, suggesting this is a sound model.

Dr. Sara Imarisio, head of Research at Alzheimers Research UK, added: Genetics plays an important role in the development diseases like Alzheimers and teasing apart the processes contributing to disease is crucial in the hunt for new breakthroughs, which will change lives. Future research capitalizing on genetic findings like this is a top priority for dementia researchers around the world. Its only thanks to the generosity of our supporters that Alzheimers Research UK is able to fund vital dementia research like this.

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Genetic Variants Linked to Disparity Between a Persons Internal Gender and Their External Sex – Technology Networks

February 12th, 2020 11:46 pm

Some of the first biological evidence of the incongruence transgender individuals experience, because their brain indicates they are one sex and their body another, may have been found in estrogen receptor pathways in the brain of 30 transgender individuals.

Twenty-one variants in 19 genes have been found in estrogen signaling pathways of the brain critical to establishing whether the brain is masculine or feminine, saysDr. J. Graham Theisen, obstetrician/gynecologist and National Institutes of Health Womens Reproductive Health Research Scholar at theMedical College of GeorgiaatAugusta University.

Basically and perhaps counterintuitively these genes are primarily involved in estrogens critical sprinkling of the brain right before or after birth, which is essential to masculinization of the brain.

Variants investigators identified may mean that in natal males (people whose birth sex is male) this critical estrogen exposure doesnt happen or the pathway is altered so the brain does not get masculinized. In natal females, it may mean that estrogen exposure happens when it normally wouldnt, leading to masculinization.

Both could result in an incongruence between a persons internal gender and their external sex. The negative emotional experience associated with this incongruence is called gender dysphoria.

They are experiencing dysphoria because the gender they feel on the inside does not match their external sex, Theisen says. Once someone has a male or female brain, they have it and you are not going to change it. The goal of treatments like hormone therapy and surgery is to help their body more closely match where their brain already is.

It doesnt matter which sex organs you have, its whether estrogen, or androgen, which is converted to estrogen in the brain, masculinizes the brain during this critical period, saysDr. Lawrence C. Layman, chief of the MCG Section of Reproductive Endocrinology, Infertility and Genetics in theDepartment of Obstetrics and Gynecology. We have found variants in genes that are important in some of these different areas of the brain.

These brain pathways are involved in regions of the brain where the number of neurons and how connected the neurons are typically differ between males and females.

They note that while this critical period for masculinizing the brain may seem late, brain development actually continues well after birth and these key pathways and receptors already need to be established when estrogen arrives.

While its too early to definitively say the gene variants in these pathways result in the brain-body incongruence called gender dysphoria, it is interesting that they are in pathways of hormone involvement in the brain and whether it gets exposed to estrogen or not, says Layman.

He and Theisen are co-corresponding authors of the study in the journalScientific Reports.

This is the first study to lay out this framework of sex-specific development as a means to better understand gender identity, Theisen says. We are saying that looking into these pathways is the approach we are going to be taking in the years ahead to explore the genetic contribution to gender dysphoria in humans.

In fact, they already are exploring the pathways further and in a larger number of transgender individuals.

For this study, they looked at the DNA of 13 transgender males, individuals born female and transitioning

to male, and 17 transgender females, born male and transitioning to female. The extensive whole exome analysis, which sequences all the protein-coding regions of a gene (protein expression determines gene and cell function) was performed at the Yale Center for Genome Analysis. The analysis was confirmed by Sanger sequencing, another method used for detecting gene variants.

The variants they found were not present in a group of 88 control exome studies in nontransgender individuals also done at Yale. They also were rare or absent in large control DNA databases.

Reproductive endocrinologist/geneticist Layman says his experience with taking care of transgender patients for about 20 years, made him think there was a biological basis. We certainly think that for the majority of people who are experiencing gender dysphoria there is a biologic component, says Theisen. We want to understand what the genetic component of gender identity is.

While genetics have been suggested as a factor in gender dysphoria, proposed candidate genes to date have not been verified, the investigators say. Most gene or gene variants previously explored have been associated with receptors for androgens, hormones more traditionally thought to play a role in male traits but, like estrogen in males, also are present in females.

MCG investigators and their colleagues decided instead to take what little is known about sex-specific brain development that estrogen bath needed in early life to ensure masculinization of the brain to hone in on potential sites for relevant genetic variances. Extensive DNA testing initially revealed more than 120,000 variants, 21 of which were associated with these estrogen-associated pathways in the brain.

Animal studies have helped identify four areas of the brain with pathways leading to development of a male or female brain, and the investigators focused on those likely also present in humans. Laboratory studies have indicated that disrupting these brain pathways in males and females during this critical period results in cross sex behavior, like female rodents mounting and thrusting and males taking on a more traditional female posture when mating. These cross sex behaviors, which also have been documented in non-human primates, emerge during the natural sex hormone surge of puberty.

While sex specific brain development has not been thoroughly evaluated in humans, as with animals, the effects typically play out most at the time of puberty, a time when sex hormones naturally surge, when the general awareness of our sexuality really begins to awaken and when the complex state of gender dysphoria may become easier for adolescents to articulate, the investigators say. Layman notes that many individuals will report experiencing gender incongruent feelings as early as age 5.

Theisen notes that we all are full of genetic variants, including ones that give us blue eyes versus brown or green, and the majority do not cause disease rather help make us individuals. I think gender is as unique and as varied as every other trait that we have, Theisen says.

The investigators suggest modification of the current system for classifying variants that would not imply that a variant means pathogenic, or disease causing.

Last year, the World Health Organization said that genderincongruenceis not a mental health disorder and six years before thatThe Diagnostic and Statistical Manual of Mental Disorders, replaced gender identity disorder with general dysphoria.

About 0.5 to 1.4% of individuals born male and 0.2 to 0.3 % of individuals born female meet criteria for gender dysphoria. Identical twins are more likely than fraternal twins to both report gender dysphoria.

Gender affirming therapies, like hormone therapies and surgeries along with mental health evaluation and support, help these individuals better align their bodies and brains, the physician-scientists say.

Transgender individuals experience increased rates of discrimination, sexual violence and are at increased risk of depression, substance abuse and attempted suicide. About 26% report use of alcohol or other drugs to help cope; 19% have been denied medical care by a physician or other provider, some report verbal harassment in a medical environment and insurance companies do not consistently cover the cost of gender affirming hormone or surgical therapies.

A problem, the investigators say, is an overall lack of understanding of the biologic basis of gender dysphoria.

While their study of 30 individuals they now have data on more than 30 others appears to be the largest to date, the sample size prompted them to classify the published findings as preliminary.

Reference: Theisen et al. (2019).The Use of Whole Exome Sequencing in a Cohort of Transgender Individuals to Identify Rare Genetic Variants. Scientific Reports.DOI: https://doi.org/10.1038/s41598-019-53500-y.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Bill moves forward to add rare genetic disease to newborn health screening in Va. – WAVY.com

February 12th, 2020 11:46 pm

NEWPORT NEWS, Va. (WAVY) A bill that aims to add a disease to newborn testing in Virginia passed in the House on Monday in a 85-12 vote. The bill now heads to the Senate.

The parents of a young Newport News boy living with the disease say this is a step in the right direction in their fight for Nikolas law.

Nikola Grujicic was born March 15, 2018. He was 6 pounds, 6 ounces and 19 1/2 inches long. He was born a healthy and happy little boy, and he had his parents wrapped around his fingers.

His parents, Dragan and Lana Grujicic, say Nikola was perfect.

From day one, he barely ever cried, he was just so content. He just wanted to be loved and cuddled.

However, before his six month appointment, their smileylittle boy starting changing. In fact, the last time Lana and Dragan Grujicic saw their son smile was when he was 16 months old at Disney World.

Nikola is now almost 2 years-old.

I turned around, and I was like oh my god, hes really grinning, Lana Grujicic said.

Shortly before his six-month check-up, Nikola became frequently cranky and would scream.Lana Grujicic also noticed Nikola was clenching his fists often. At the appointment, she told the pediatrician about her concerns and when a few reflex tests didnt come back as they should have, a neurologist was recommended.

The pediatric neurologist ran a battery of tests on Nikola and after an agonizing three-week wait, the Grujicics were called in to get the results.

The news was devastating: Nikola was diagnosed with a rare, inherited condition called Krabbe Disease.

I wouldnt wish this on my worst enemy. I dont want a simple family to go through what weve been through, what we are going through, said Dragan Grujicic.

The myelin or white matter in the brain is affected by Krabbe Disease and patients lose their ability to move, speak, see, hear, eat and drink. Life expectancy for infantile Krabbe Disease is less than two years.

Its the reason why the family created Nikolas law, or House Bill 97.The family wants to add Krabbe disease and otherLeukodystrophies that affect the brain and spinal cord to the newborn screening in Virginia.

If I could go back and save him, I would, but I cant. This way I can. His legacy can be he can save other lives, said Dragan Grujicic.

With the help of advocates like Hunters Hope in New York and Del. Jason Miyares, the bill was written.

I made a promise to the family that I would introduce this legislation and advance this, Miyares said.My hope is that we can get this on the books so other parents dont go through the agony weve seen in this situation.

Last month, the Health, Welfare and Institutions committee voted to move Nikolas Law (HB 97) to the appropriations committee. It went under re-review and, in a big push forward, it was approved 85-12 in the House.

The bill now moves to the Senate.

For Nikola, his mother can only manage the disease. He was diagnosed too late for treatment that would help alleviate his symptoms and slow their progression. Treatment involves the use of umbilical cord blood shortly after birth. Cells that carry proteins the Krabbe patient is missing are transplantedlike a blood transfusion.

The procedure, however, can only be done shortly after birth because the disease progresses so quickly. As a result, a newborn screening test is the best method to know whether or not an infant has Krabbe.

I remember asking doctors, Why didnt you test me for this? You tested me for everything while I was pregnant,' Lana Grujicic said.

The test, she says, would have cost $6. It would happen during the routine blood test at three months into a pregnancy.

I cant understand why its so difficult to run another blood test and why you wouldnt want to, Lana Grujicic said.We are not going to stop. Its only a matter of when. We are not going to be willing to see other babies go through this and have Nikola go through this for nothing.

One in 125 people carry Krabbe disease.

Its only an issue if two carriers have a baby. If they do have a child, theres a 25 percent chance the baby will be affected.

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