header logo image


Page 680«..1020..679680681682..690700..»

‘Complex’ issue of type 1 diabetes to be addressed in Australian schools – NEWS.com.au

February 16th, 2020 7:44 pm

Diabetes Australia Program Manager Renza Scibila has spoken with Sky News about the "complex" condition and a new program which is aimed at raising awareness and training for students with the disease. The 'Diabetes in Schools program' aims to develop a deliver a nationally consistent training program for both school-staff and teachers, to be able to safely administer and manage students who are impacted by the disease. Currently 25 percent of parents with children with type 1 diabetes are having to visit schools to administer insulin to their children. "There hasn't been a collaborative approach and we have that now with our new 'Diabetes in Schools Program'," Ms Scibila said. "Type 1 diabetes is a really complex condition so parents don't just send their kids off at the beginning of the day and then not think about it again."[For] children with diabetes, their management happens at home and then throughout the school day and then at the end of the day and overnight as well."

Read more here:
'Complex' issue of type 1 diabetes to be addressed in Australian schools - NEWS.com.au

Read More...

My Third Stem Cell Treatment for MS – Everyday Health

February 15th, 2020 5:46 pm

Since 2014, I have had three stem cell treatments, each time hoping it would help fight off the progression of my multiple sclerosis (MS) symptoms. Because the procedures Ive undergone do not have a very long history of use or many studies to support them, Ive basically made myself a guinea pig by trying them.

So far, Ive experienced failure and success, but overall, the positives have been life-changing for me. I am continuing down this path of healing because there is currently no cure for MS, and now that Im 61, time is not on my side for a cure to be discovered!

In 2014, I had a procedure in which adult stem cells were isolated from my fat tissue, grown in a lab, and reinfused into my body. Initially I had great results, but they were short-lived, and within three months, all my MS symptoms had returned.

In 2018, I had a different type of procedure, in which 300 million stem cells derived from umbilical cord tissue were infused into my arm. I wrote about my experience in a blog just two months after that infusion. At the time, I was having a positive response, but I was also skeptical, since I had seen similar early improvements in 2014.

Two weeks after my 2018 treatment, my left-side drop foot was gone, I could jump off the floor, and I had regained some feeling in my left arm. But I needed to give this new stem cell treatment some more time before I could positively state that this one had worked. So I waited and kept working out in the gym as I have always done, pushing myself harder as time went by.

I found my body getting stronger and stronger as the months passed, and I even filmed myself squatting 500 pounds and posted it in our MS Fitness Challenge GYM Facebook group to show the community that I was not just imagining the results.

Months after the treatment, my left leg was almost as good as my right one, which has never been affected by MS, and my overall strength was increasing.

By the eighth month or so, I was running on the treadmill, and at approximately nine months post-infusion, I was jumping rope. I had not run or jumped rope in almost 14 years.

I was and am extremely happy with what my legs are now capable of, but I only got partial feeling back in my left arm and hand, and I want that back the same way I have my left leg back.

With that goal in mind, I reached out to the doctor who had performed my stem cell procedures and asked if I was eligible for more cells. I also asked if he thought more cells would bring back the feeling in my left arm and hand.

His response was that no one had predicted what results I would get from the 2018 treatment, and here I was running, jumping rope, and squatting like a champion. So we had nothing to lose by transfusing another 300 million cells into my body. We both thought that since my leg no longer needed the stem cells, maybe they would find their way to my arm!

Theoretically, stem cells go where theyre needed to repair the damage.It seemed worth a shot, so I booked my flight to the Cayman Islands for a January 2020 infusion. And now I am home.

Its only been a few weeks, but I can already feel hot and cold in my left hand, which I have not been able to do since 2006, when I was diagnosed.

Again, I am cautiously optimistic that I will get similar results in the areas I need them now. But only time will tell. All I can say is that this therapy has changed my life, and I am hopeful that an ongoing clinical trial of the stem cell treatment I received will provide evidence that it will also be helpful to others with MS.

See the rest here:
My Third Stem Cell Treatment for MS - Everyday Health

Read More...

Indian doctors fix Yemeni man’s face in rare reconstructive surgery – The New Indian Express

February 15th, 2020 5:46 pm

By Express News Service

NEW DELHI: A 26-year-old man from Yemen received a fresh lease of life through a rare reconstructive surgery, performed by a team of Indian doctors. A few months back, the patients face and mouth was left completely disfigured after a mobile phone exploded while he held it between his teeth. Apart from severe disfigurment, the accident rendered him incapable to eat and speak properly.

The patient was admitted at KAS Medical Centre in the national capital where a team of facial reconstruction surgeons headed by Dr. Ajaya Kashyap performed a rare surgical procedure to give him his normal facial features back. As per the doctors, the blast was so strong that it burnt the inside of his mouth, tore up the muscles and the tongue leaving all the soft tissues damaged.

As the blast happened inside the mouth, the injury was rather unusual. After much assessment, the team decided to use flaps of tissue from inside the mouth as well as fat tissues from his body and use it as a flap. Ensuring facial sensations was another challenge. We are happy that the procedure went well and the patient regained his normal features, said Kashyap, Medical Director, KAS Medical Centre.

The muscles of the lips which had been split apart were repaired and flaps were used to close it. Autologous fat with stem cells and PRP were injected to restore volume and improve scarring.

The surgery was done a week back and now he is ready to fly back to his own country, added Kashyap.

Mobile phone blasts have lead to serious injuries in India. The most common reasons for a cell phone to explode are using it while the phone is being charged. Charging puts pressure on the device, using it during charging increases this pressure manifold. This causes cheap electronic components in some mobiles to explode.

Originally posted here:
Indian doctors fix Yemeni man's face in rare reconstructive surgery - The New Indian Express

Read More...

Fountain of Youth within reach without surgery – KIIITV.com

February 15th, 2020 5:46 pm

CORPUS CHRISTI, Texas In today's world, millions are spent on cosmetic surgery to keep that healthy glow everywhere we go. However, if you don't have thousands of dollars to pay for it, there are other, more safe alternatives that are non-surgical.

A few years ago I started noticing that no matter how much sleep I got, I just didn't look as fresh as I did when I was younger. I thought maybe it was time to talk to a professional about how I could get back that youthful appearance.

Stress, the daily rigor of life, and gravity all take their toll on the face, and there's nothing wrong with admitting you need a little help to look and feel a little better.

I visited with Dr. Vijay Bingdingdavale, a local cosmetic surgeon, to address my concerns and explore some options. The first thing he suggested was injections to relax my forehead area.

"That'll lift the eyebrows as well. What happens is when we inject these two areas, your eyebrows come a little bit higher, and giving you more of a refreshed look," Dr. Bingdingdavale said.

Then adding fullness to the upper cheeks would bring some balance to my face.

"You see how when you have a little bit more cheek fullness it harmonizes the face? It lifts this and fill this in as well," Dr. Bingdingdavale said.

Using fat transfer as opposed to artificial fillers has an additional benefit.

"We see this a lot, because there are stem cells in the fat, it makes the overlying skin more refreshed and more young-looking," Dr. Bingdingdavale said.

In the end, that's what we all want -- a more refreshed appearance even if we don't get our eight hours every night.

You can catch Dr. Vijay Bingdingdavale on First Edition on Sundays discussing skin care and healthy living.

More from 3News on KIIITV.com:

Originally posted here:
Fountain of Youth within reach without surgery - KIIITV.com

Read More...

Get ready for micro HIIT: the seven-minute workout that could transform your body, and your life – Telegraph.co.uk

February 15th, 2020 5:46 pm

Its cold, its dark, and youve got zero motivation. Well, one trainer has good news for you: you only need to commit to seven minutes, three to four times a week. Not only could you lose weight and build muscle something thats essential for everyone over the age of 30 but it builds up bone density and targets belly fat, a common midlifer problem. Sounds do-able, right?

HIIT is nothing new you see people doing it in their local park every weekend. But Zana Morris, personal trainer and founder of The Clock gyms in London, has a unique take: we need to do it much harder and for a much shorter time. "You should be totally exhausted after six reps, Morris says, then you move on to the next exercise.

"The key is to think of it like sprint training: you wouldnt sprint for 45 minutes, you run all out for a few minutes. Its the same with HIIT when youre doing it right its about short, sharp bursts.

When I join Morris well-heeled, mainly middle-aged clients at her luxe Marleybone gym for a month in December, I do a different circuit on each visit, either legs and bum, shoulders and arms or back and chest, and am out the door in under 10 minutes. Its a get in, get on, get the job done approach, Morris laughs.

Her approach, which she has been honing for more than 20 years, is backed up by a plethora of research, including a recent study in The American College of Sports Medicine (ACSM) Journal which found that seven minutes was enough to get the fitness benefits. You really can see a difference fast when you do seven minute really intense sessions, Morris says. On average, when you team it with the right nutrition, we see clients lose around 6-7lbs of fat and gain 2-3lbs of muscle.

The reason, Morris explains, is down to our hormones, particularly insulin levels. Any weight around our middle is insulin related, she says. Put simply, insulin, the hormone that regulates the levels of glucose in the blood, can cause weight gain when the cells absorb too much glucose or blood sugar and convert it into fat. Not only can it make you fatter, but in a catch-22 situation, increased body weight can also lead to higher insulin levels. Sleep affects your insulin levels, as does eating carb-heavy or sugary foods and stress all midlifer concerns.

But micro HIIT sessions can reverse that a study published in the journal Frontiers found that a ten-week HIIT training programme in sedentary adult women at risk for type-2 diabetes had positive effects on their insulin levels, while a separate Brazilian study confirmed the same thing, looking at sleep-deprived men and the effect that HIIT had on their insulin levels.

Theres an added benefit to performing HIIT, according to Pamela Peeke, assistant professor of medicine at the University of Maryland and Equinox Health Advisory Board member: The healthy stress your body undergoes during HIIT triggers autophagy, which rids your body of cellular debris and stimulates the production of stem cells, the primary regenerative cells in the body. The more stem cells you have, the better you are able to induce super autophagyits a cycle. Think of it as a spring-clean for your cells.

Peeke recommends HIIT training three times per week plus find every opportunity to add one, two, three minutes of HIIT to your day." Such as doing as many squats as you can in a minute while you wait for the kettle to boil or racing for the bus at a full-out pelt.

But for added benefit, as Morris has found with herself (she has roughly the same body composition now shes in her mid-forties as she did as a 20-year-old) and her clients, is to add in weights. After the age of thirty, we lose between 3-5pcof muscle per decade in a process called sarcopenia (most men will lose about 30pcof their muscle mass during their lifetimes). Its problematic because it not only leads to diminished strength as we get older, but makes us more prone to breakages, according to a study from the American Society for Bone and Mineral Research.

More pressingly, the amount of muscle you have has affects on your weight. Its estimated that 1lb of muscle burns about 50-100 calories per day, Morris explains. So, by the time youre 40, if youve already lost around 5lbs of muscle due to natural age-related wastage, you would need 500 calories less per day. But not many of us reduce our calorific intake in fact, we often increase it. The antidote is to try to rebuild that muscle.

When I train with Morris for four weeks over December, I build up my strength surprisingly quickly. In four weeks I am able to lift 110 kgs on the bench press machine, up from 80kgs at the start. In a month I gain 2.5 lbs of muscle taking me back to my twenty-something levels.

While having a trainer on hand to set your weights up is a luxury, the exercises are easy to replicate at home or in your own gym. You can do 60 squats in a minute, or as many as you can do, or swimming sprints in your pool. You can do it with almost any exercise, Morris says. But dont in the zeal of January restarts think that more is better. In fact, going over the 30-minute mark has negative effects on our ability to build muscle because we start to produce cortisol, which can lead to muscle atrophy. Morris shudders when she thinks of midlifers doing marathons and triathlons (I darent tell her Im one of them).

At the same time nutritionist Mackenzie Dumas looks at my diet. She points out that theres little point training if Im going to continue with my nightly Maltesers/ half a bottle of wine habit. For the first 12 days Im on a high fat, low carbohydrate diet which comprises of a lot of avocado and eggs, and almost zero carbs. During this period, I lose eight pounds of fat, according to Dumas callipers. Then she moves me onto a more sustainable high protein, low carbohydrate diet, which is broadly what the surgeon Dr Andrew Jenkinson author of Why We Eat (Too Much), recently recommended in The Telegraph.

The month under Morris's guidance has been a huge re-education in fitness. Out goes the half-hearted Sunday morning boot campbootcamp in the park, replaced by seven-minute power sessions with my kettlebell.

Continued here:
Get ready for micro HIIT: the seven-minute workout that could transform your body, and your life - Telegraph.co.uk

Read More...

Mobile blast in mouth injure Yemen youth, gets fresh lease of life with facial reconstruction surgery in India – Devdiscourse

February 15th, 2020 5:46 pm

A 26-year-old youth from Yemen, Saad-Ul- Haq (name changed) has received a fresh lease of life by getting his normal face back through a rare reconstructive surgery, performed by a team of Indian doctors. A few months back, Saad's face and mouth was left completely disfigured after a mobile blasted in his mouth which he had held between his teeth while doing some work.

Apart from severe disfiguring, the accident rendered him incapable to eat and speak normally, said doctors. Team of facial Reconstruction Surgeons headed by Dr Ajaya Kashyap performed a rare surgical procedure to give Saad his normal facial features back.

The blast was so strong that it burnt the inside of his mouth, tore up the muscles and the tongue leaving all the soft tissues damaged, said the doctors. Dr Ajaya Kashyap, Medical Director, KAS Medical Centre, New Delhi said "As the blast happened inside the mouth, the injury was rather unusual. After much assessment, the team decided to use flaps of tissue from inside the mouth as well as fat tissues from his body and use it as a flap. Ensuring facial sensations was another challenge. We are happy that the procedure went well and the patient regained his normal features."

"The muscles of the lips which had been split apart were repaired and flaps were used to close it. Autologous fat with stem cells and PRP were injected to restore volume and improve scarring. The surgery of Saad was done a week back and now he is ready to fly back to his own country," said Dr Kashyap. Sharing his experience in India, Saad (patient) said, "The blast had taken everything that was positive in me. Unable to eat and speak, just a few months ago I was the most hopeless man. When we started off from Yemen, all I hoped was to get my normal features back. For me, the surgery has changed everything. Now I can get settled in my life and get married to my girl without feeling insecure about my looks." (ANI)

(This story has not been edited by Devdiscourse staff and is auto-generated from a syndicated feed.)

Download The Devdiscourse News App for Latest News.

See the original post here:
Mobile blast in mouth injure Yemen youth, gets fresh lease of life with facial reconstruction surgery in India - Devdiscourse

Read More...

Is soaking in a frozen lake the secret to good health? – The Detroit News

February 15th, 2020 5:44 pm

Richard Chin, Star Tribune (minneapolis) Published 5:55 p.m. ET Feb. 11, 2020

Ponce de Leons search for the fountain of youth in Florida is just a legend.

But about 1,500 miles to the north, in the icy waters of Cedar Lake in Minneapolis, dozens of people think theyve found the next best thing.

On a recent Sunday around 9:30 a.m., a diverse group of about 20 people dressed in swimsuits trekked to a spot near the shore on the west side of the lake and immersed themselves in an 8-by-12-foot rectangular hole cut in the ice. Later in the day, another group of people gathered to do the same thing.

This isnt a once-a-year, get-in, get-out, New Years Day plunge for Instagram bragging rights.

Throughout the winter, biohackers maintain a hole in the ice chopped into Cedar Lake in Minneapolis in the belief that regular cold water immersions make them healthier.(Photo: Richard Tsong-Taatarii / TNS)

This is something that happens every Sunday throughout the winter.

Some people come several times a week, and stay for a good, long soak of five, 10, 15 minutes or more. Except for the knit hats, they look like they could be relaxing in a hot tub as they stand in water that ranges from waist- to neck-deep.

Called cold therapy or cold thermogenesis, ice-water bathing is a practice that biohackers and assorted others believe makes them healthier.

The Twin Cities Cold Thermogenesis Facebook group, which was created in 2016, claims the frigid dips do everything from increase testosterone in men to boosting brown adipose tissue. (The so-called brown fat or good fat may be helpful in combating obesity because it burns calories to create heat.)

Cold-water immersion also strengthens the immune system, according to Svetlana Vold, a part-time firefighter and ultramarathon winter bike racer from St. Louis Park, who organizes the Sunday morning cold-immersion session.

Vold and others say chilling out in the water combats inflammation, helps them sleep better and improves their focus and endurance. Some said theyre inspired by Wim The Iceman Hof, a Dutchman famous for his breathing and cold exposure technique called the Wim Hof Method.

The Cedar Lake group would probably meet the approval of David Sinclair, a Harvard genetics professor and longevity expert who thinks that cold exposure may help slow the aging process.

Maria OConnell, the organizer of the afternoon session, has been immersing herself in an ice-filled horse trough in her backyard since 2011. Initially its a little uncomfortable, she said. You end up getting better the more you do it.

But many say the frigid dunks are a mood-altering, even pleasurable experience.

It hurts so damn good, said Stephen McLaughlin, a 61-year-old Minneapolis resident. You are just completely present.

It makes me happy. I think its adrenaline, said Allison Kuznia, 42, of Minneapolis.

Its kind of a treat to go out and get really cold, said Nick White, 46, of Minneapolis. It gives you a feeling of euphoria.

Read or Share this story: https://www.detroitnews.com/story/life/wellness/2020/02/11/soaking-frozen-lake-secret-good-health/41217451/

See the original post here:
Is soaking in a frozen lake the secret to good health? - The Detroit News

Read More...

My Corner, Your Corner: Gone, but never to be forgotten – The Sunday Dispatch

February 15th, 2020 5:44 pm

It was a rough two weeks for notables in Greater Pittston.

We lost centurion Michael Augello, and local musicians Charles Infantino and Ralph Barber.

Charles and Ralph lost their lives at a time when, at 67 and 65, respectively, there is a lot more living to do.

Charles and Ralph were music people where Charles played bass guitar and trombone and, I believe, Ralph played bass, as well.

Ralph played with the New York Times Band for over 30 years. If you never heard the band play, you missed out.

We also lost former PA State Police Trooper, Luzerne County sheriff and former West Pittston councilman Barry Stankus. Lets not forget his duties in the deli at Gerritys Market in West Pittston. Barry was 69 again, way too soon.

Barry was a great guy and loved by many; he was a West Pittstonian through and through growing up there, graduating from Wyoming Area, serving there and working in the community.

At 100 years old, Mr. Augello was definitely in the plus range. Not only did he live a long life, he was productive just about every single year of his life.

There are a few people I can think of in that age range who were very active in their later years like Bill Hastie, of West Pittston; Dr. John Markarian, also of West Pittston; and our buddy Chester Montante, all over 100.

I just met Hank Cordy, an Avoca native now living at Wesley Village, whos pretty active himself. I had the chance to write about Hank and everyone loved his success to a long life a nip and a nap a nip of booze and a nap to go with it. Not a bad idea, dont you think?

A decade ago, turning 100 was something so far-fetched it didnt seemed possible and was very rare. Ive covered my fair share of 100-year-old birthdays over the last several years.

John Markarian will turn 103 on June 7. From what I hear, it wasnt too long ago John was still hitting the links on the golf course. Ill have some of whatever hes eating.

Genetics, environment and what you eat assuredly play a roll in longevity. It always amazes me when I meet someone whos 100 yeas old and sharp. Most dont even look close to their age.

I met Josephine Lazzari in 2013. She was 100 years old at the time and I would have bet the farm she wasnt a day over 80. She was a member of the Blooms and Bubbles Chapter of the Red Hat Society.

I had the assignment of taking a photo of the Red Hats at Fox Hill Country Club where they were honoring Josephine on her 100th birthday. I walked into the small room filled with women in their red hats. As I stood near the table, I looked around, carefully trying to eye someone I thought could have been 100.

I got a glimpse of some of the women with walkers and canes and, yes, I was stereotyping at the time, but I had no idea which one was the guest of honor.

So I spoke up, Which one of you would be the birthday girl? No one raised their hand but, as I was scanning the room, the person sitting near me tugged on my jacket. I looked down and it was Josephine.

Naturally, my first reaction was, Youre not 100 years old!

I gathered the ladies and told them we would take the group photo in the lobby area. There was music playing throughout the PA system and, when the women started making their way to the lobby, Josephine got out of her chair and danced to the music on the way.

I was amazed at the energy she had. But what really shocked me was, she told me she had a major heart attack at the age of 80. This woman made the best of her life for the next 21 years. She said the secret of her life was to love everyone.

Josephine penned an article when she turned 100 stemming from that birthday party at Fox Hill.

The article appeared in the Sunday Dispatch on April 25, 2013 two days before her 100th birthday.

She said, Celebrating my 100th birthday has been like a Polish wedding. I have been honored and remembered by the St. Joseph Senior Social Club, the members of the Altar and Rosary Society of St. John the Evangelist Parish Community, my sister Red Hats of Blooms and Bubbles of Greater Pittston, the officials, firefighters and policemen of Pittston City and, on my birthday on April 27, with a family and friends party. I am very grateful to all who remembered me.

I sure havent forgotten Josephine and her zest for life at 100 years of age.

I wont forget Charles and all he touched, along with his contagious smile and his love of family, church and God.

I wont forget Barry and I wont forget Ralph and his musical talent.

I wont forget how, at 100, it was important to Michael Augello to get up every morning to make soup for his customers.

Rest easy you will never be forgotten.

Quote of the week

Just as a candle cannot burn without fire, men cannot live without a spiritual life. Buddha

Thought of the week

Love shall be our token; love be yours and love be mine. Christina Rossetti

Bumper sticker

Things are beautiful if you love them. Jean Anouilh

Reach the Sunday Dispatch newsroom at 570-991-6405 or by email at sd@psdispatch.com.

Excerpt from:
My Corner, Your Corner: Gone, but never to be forgotten - The Sunday Dispatch

Read More...

13 Habits Linked to a Long Life (Backed by Science)

February 15th, 2020 5:43 pm

Many people think that life expectancy is largely determined by genetics.

However, genes play a much smaller role than originally believed. It turns out that environmental factors like diet and lifestyle are key.

Here are 13 habits linked to a long life.

The link between calorie intake and longevity currently generates a lot of interest.

Animal studies suggest that a 1050% reduction in normal calorie intake may increase maximum lifespan (1).

Studies of human populations renowned for longevity also observe links between low calorie intake, an extended lifespan, and a lower likelihood of disease (2, 3, 4).

What's more, calorie restriction may help reduce excess body weight and belly fat, both of which are associated with shorter lifespans (5, 6, 7).

That said, long-term calorie restriction is often unsustainable and can include negative side effects, such as increased hunger, low body temperature, and a diminished sex drive (3).

Whether calorie restriction slows aging or extends your lifespan is not yet fully understood.

Nuts are nutritional powerhouses.

They're rich in protein, fiber, antioxidants, and beneficial plant compounds. Whats more, theyre a great source of several vitamins and minerals, such as copper, magnesium, potassium, folate, niacin, and vitamins B6 and E (8).

Several studies show that nuts have beneficial effects on heart disease, high blood pressure, inflammation, diabetes, metabolic syndrome, belly fat levels, and even some forms of cancer (9, 10, 11, 12).

One study found that people who consumed at least 3 servings of nuts per week had a 39% lower risk of premature death (13).

Similarly, two recent reviews including over 350,000 people noted that those who ate nuts had a 427% lower risk of dying during the study period with the greatest reductions seen in those who ate 1 serving of nuts per day (14, 15).

When it comes to anti-aging strategies, turmeric is a great option. Thats because this spice contains a potent bioactive compound called curcumin.

Due to its antioxidant and anti-inflammatory properties, curcumin is thought to help maintain brain, heart, and lung function, as well as protect against cancers and age-related diseases (16, 17, 18, 19, 20, 21, 22).

Curcumin is linked to an increased lifespan in both insects and mice (23, 24, 25).

However, these findings have not always been replicated, and no human studies are currently available (26, 27).

Nevertheless, turmeric has been consumed for thousands of years in India and is generally considered safe.

Consuming a wide variety of plant foods, such as fruits, vegetables, nuts, seeds, whole grains, and beans, may decrease disease risk and promote longevity.

For example, many studies link a plant-rich diet to a lower risk of premature death, as well as a reduced risk of cancer, metabolic syndrome, heart disease, depression, and brain deterioration (28, 29, 30, 31).

These effects are attributed to plant foods nutrients and antioxidants, which include polyphenols, carotenoids, folate, and vitamin C (32).

Accordingly, several studies link vegetarian and vegan diets, which are naturally higher in plant foods, to a 1215% lower risk of premature death (33, 34).

The same studies also report a 2952% lower risk of dying from cancer or heart, kidney, or hormone-related diseases (33, 34).

Whats more, some research suggests that the risk of premature death and certain diseases increases with greater meat consumption (35, 36, 37).

However, other studies report either nonexistent or much weaker links with the negative effects seeming specifically linked to processed meat (38, 39).

Vegetarians and vegans also generally tend to be more health-conscious than meat eaters, which could at least partly explain these findings.

Overall, eating plenty of plant foods is likely to benefit health and longevity.

It should come as no surprise that staying physically active can keep you healthy and add years to your life (40).

As few as 15 minutes of exercise per day may help you achieve benefits, which could include an additional 3 years of life (41).

Furthermore, your risk of premature death may decrease by 4% for each additional 15 minutes of daily physical activity (41).

A recent review observed a 22% lower risk of early death in individuals who exercised even though they worked out less than the recommended 150 minutes per week (42).

People who hit the 150-minute recommendation were 28% less likely to die early. What's more, that number was 35% for those who exercised beyond this guidance (42).

Finally, some research links vigorous activity to a 5% greater reduction in risk compared to low- or moderate-intensity activities (43).

Smoking is strongly linked to disease and early death (44).

Overall, people who smoke may lose up to 10 years of life and be 3 times more likely to die prematurely than those who never pick up a cigarette (45).

Keep in mind that it's never too late to quit.

One study reports that individuals who quit smoking by age 35 may prolong their lives by up to 8.5 years (46).

Furthermore, quitting smoking in your 60s may add up to 3.7 years to your life. In fact, quitting in your 80s may still provide benefits (44, 46).

Heavy alcohol consumption is linked to liver, heart, and pancreatic disease, as well as an overall increased risk of early death (47).

However, moderate consumption is associated with a reduced likelihood of several diseases, as well as a 1718% decrease in your risk of premature death (47, 48).

Wine is considered particularly beneficial due to its high content of polyphenol antioxidants.

Results from a 29-year study showed that men who preferred wine were 34% less likely to die early than those who preferred beer or spirits (49).

In addition, one review observed wine to be especially protective against heart disease, diabetes, neurological disorders, and metabolic syndrome (50).

To keep consumption moderate, it is recommended that women aim for 12 units or less per day and a maximum of 7 per week. Men should keep their daily intake to less than 3 units, with a maximum of 14 per week (51).

It's important to note that no strong research indicates that the benefits of moderate drinking are greater than those of abstaining from alcohol.

In other words, there is no need to start drinking if you don't usually consume alcohol.

Feeling happy can significantly increase your longevity (52).

In fact, happier individuals had a 3.7% reduction in early death over a 5-year study period (53).

A study of 180 Catholic nuns analyzed their self-reported levels of happiness when they first entered the monastery and later compared these levels to their longevity.

Those who felt happiest at 22 years of age were 2.5 times more likely to still be alive six decades later (54).

Finally, a review of 35 studies showed that happy people may live up to 18% longer than their less happy counterparts (55).

Anxiety and stress may significantly decrease your lifespan.

For instance, women suffering from stress or anxiety are reportedly up to two times more likely to die from heart disease, stroke, or lung cancer (56, 57, 58).

Similarly, the risk of premature death is up to three times higher for anxious or stressed men compared to their more relaxed counterparts (59, 60, 61).

If you're feeling stressed, laughter and optimism could be two key components of the solution.

Studies show that pessimistic individuals have a 42% higher risk of early death than more optimistic people. However, both laughter and a positive outlook on life can reduce stress, potentially prolonging your life (62, 63, 64, 65).

Researchers report that maintaining healthy social networks can help you live up to 50% longer (66).

In fact, having just 3 social ties may decrease your risk of early death by more than 200% (67).

Studies also link healthy social networks to positive changes in heart, brain, hormonal, and immune function, which may decrease your risk of chronic diseases (68, 69, 70, 71, 72).

A strong social circle might also help you react less negatively to stress, perhaps further explaining the positive effect on lifespan (73, 74).

Finally, one study reports that providing support to others may be more beneficial than receiving it. In addition to accepting care from your friends and family, make sure to return the favor (75).

Conscientiousness refers to a person's ability to be self-disciplined, organized, efficient, and goal-oriented.

Based on data from a study that followed 1,500 boys and girls into old age, kids who were considered persistent, organized, and disciplined lived 11% longer than their less conscientious counterparts (76, 77).

Conscientious people may also have lower blood pressure and fewer psychiatric conditions, as well as a lower risk of diabetes and heart or joint problems (78).

This might be partly because conscientious individuals are less likely to take dangerous risks or react negatively to stress and more likely to lead successful professional lives or be responsible about their health (79, 80, 81).

Conscientiousness can be developed at any stage in life through steps as small as tidying up a desk, sticking to a work plan, or being on time.

Both coffee and tea are linked to a decreased risk of chronic disease.

For instance, the polyphenols and catechins found in green tea may decrease your risk of cancer, diabetes, and heart disease (82, 83, 84, 85, 86).

Similarly, coffee is linked to a lower risk of type 2 diabetes, heart disease, and certain cancers and brain ailments, such as Alzheimer's and Parkinson's (87, 88, 89, 90, 91, 92).

Additionally, both coffee and tea drinkers benefit from a 2030% lower risk of early death compared to non-drinkers (93, 94, 95, 96).

Just remember that too much caffeine can also lead to anxiety and insomnia, so you may want to curb your intake to the recommended limit of 400 mg per day around 4 cups of coffee (97, 98).

It's also worth noting that it generally takes six hours for caffeine's effects to subside. Therefore, if you have trouble getting enough high-quality sleep, you may want to shift your intake to earlier in the day.

Sleep is crucial for regulating cell function and helping your body heal.

A recent study reports that longevity is likely linked to regular sleeping patterns, such as going to bed and waking up around the same time each day (99).

Sleep duration also seems to be a factor, with both too little and too much being harmful.

For instance, sleeping less than 57 hours per night is linked to a 12% greater risk of early death, while sleeping more than 89 hours per night could also decrease your lifespan by up to 38% (100, 101).

Too little sleep may also promote inflammation and increase your risk of diabetes, heart disease, and obesity. These are all linked to a shortened lifespan (102, 103, 104, 105).

On the other hand, excessive sleep could be linked to depression, low physical activity, and undiagnosed health conditions, all of which may negatively affect your lifespan (106).

Longevity may seem beyond your control, but many healthy habits may lead you to a ripe, old age.

These include drinking coffee or tea, exercising, getting enough sleep, and limiting your alcohol intake.

Taken together, these habits can boost your health and put you on the path to a long life.

Visit link:
13 Habits Linked to a Long Life (Backed by Science)

Read More...

How to live longer: Drinking this many cups of coffee can boost life longevity – Express

February 15th, 2020 5:43 pm

When it comes to living a life disease-free, filled with energy and happiness and an impressive amount of time - everyone is intrigued. In fact, internet searches on the matter is astronomical with everyone wanting to know what is the secret. A certain hot beverage has been proven to add extra years to ones life and even reduce the risk of developing Alzheimers.

Drinking as little as two cups of coffee a day can increase life expectancy by a staggering two years, according to researchers.

The research, published in the European Journal of Epidemiology, was conducted by analysing previous studies on the health benefits of drinking coffee.

Looking at the 40 studies conducted including 3,852 651 subjects and 450,256 causes of death, researchers found that drinking coffee had an inverse association with all-cause mortality irrespective of age, weight, alcohol consumption, smoking status and caffeine content of coffee.

DONT MISS

In recent years and decades, scientists have studied the effects of coffee on various aspects of health.

The research has shown that coffee doesnt just help to keep you awake - it can also make a person smarter.

Caffeine works in the brain by blocking the effects of an inhibitory neurotransmitter called adenosine.

By blocking the inhibitory effects of adenosine, caffeine actually increases neuronal firing in the brain and the release of other neurotransmitters like dopamine and norepinephrine, improving both mood and brain function.

More here:
How to live longer: Drinking this many cups of coffee can boost life longevity - Express

Read More...

Local Angus Breeder Recognized for Sustained Efforts to Improve Cow Productivity – The Herald Journal

February 15th, 2020 5:43 pm

Ipsen Cattle Company, Dingle, Idaho, recently re-enrolled in the American Angus Association whole-herd reporting system MaternalPlus as a commitment to making genetic improvements in lifetime cow herd productivity. Breeders participating in MaternalPlus are keenly focused to better evaluate herd reproductive performance, the number one profit driver in the cow-calf industry.

MaternalPlus is a voluntary, inventory-based reporting system that collects additional reproductive trait data to provide Angus breeders and their customers the information they need to make effective selection decisions. To date, more than 140 breeders have completed MaternalPlus enrollment.

The program allows producers to capture cow herd and reproductive performance data, gain faster access to preweaning EPDs as a selection tool, characterize females through heifer pregnancy EPDs tied directly to herd genetics, expand new trait development for Angus reproductive and longevity measures, and streamline their ability to track heifer and cow reproductive records through AAA Login.

In addition, MaternalPlus lays the groundwork for selection tools related to cow longevity in the herd. Gathering these records will allow the Association to cultivate research related to cow herd productivity and make improvements similar to what the Angus breed has witnessed in other economically relevant traits.

For more information on MaternalPlus, visit the Association website or access AAA Login.Ipsen Cattle Company, Dingle, Idaho, recently re-enrolled in the American Angus Association whole-herd reporting system MaternalPlus as a commitment to making genetic improvements in lifetime cow herd productivity. Breeders participating in MaternalPlus are keenly focused to better evaluate herd reproductive performance, the number one profit driver in the cow-calf industry.

Story continues below video

MaternalPlus is a voluntary, inventory-based reporting system that collects reproductive trait data to provide Angus breeders and their customers the information they need to make effective selection decisions. To date, more than 140 breeders have completed MaternalPlus enrollment.

The program allows producers to capture cow herd and reproductive performance data, gain faster access to preweaning EPDs as a selection tool, characterize females through heifer pregnancy EPDs tied directly to herd genetics, expand new trait development for Angus reproductive and longevity measures.

In addition, MaternalPlus lays the groundwork for selection tools related to cow longevity in the herd. Gathering these records will allow the Association to cultivate research related to cow herd productivity and make improvements similar to what the Angus breed has witnessed in other economically relevant traits.

For more information on MaternalPlus, visit the Association website or access AAA Login.

Link:
Local Angus Breeder Recognized for Sustained Efforts to Improve Cow Productivity - The Herald Journal

Read More...

Liver Detox: 6 Foods To Boost and Cleanse Your Liver – Longevity LIVE

February 15th, 2020 5:43 pm

When it comes to ensuring that the body stays healthy, the liver is definitely at the forefront. Often referred to as the bodys personal detoxing system, the liver helps to keep your body healthy and clean by removing toxins from the body. If thats not enough, this vital organ is also responsible for destroying old blood cells, ensuring that nutrients are more easily absorbed, storing minerals, iron, and vitamin A, as well as producing essential proteins and cholesterol and produce bile to break down and digest fats. That said, its no wonder that people are concerned with maintaining the health of the liver, and as such if theres one trend that will never die, its a liver detox.

Before we get into the effectiveness of a liver detox, its best to first discuss what would bring someone to it. As mentioned, the liver is the bodys personal detox system, and if its compromised, then youre definitely going to feel the effects. That said, below are signs that your liver may need a little help;

Now while the average person may associate poor liver function with excessive alcohol consumption which is fair there are other facts that can compromise your bodys liver function. These include;

A liver detox, or cleanse, often takes the shape of fasting on cayenne-infused lemon water for a week, in hopes of cleaning your liver and even losing weight. Now, while this health fad is often featured on every health website known to men, there are a few concerns when it comes to liver detoxes and cleanses.

For one, these cleanses can be dangerous as they often encourage people to go on diets and fasts that may deprive them of essential nutrients, leading to deficiencies and malnutrition. Whats more, there have yet to be any scientific studies that support the benefits of liver detoxes. Whats more, the products that claim to help to detox the liver are not regulated. Essentially, there is a low chance of an unhealthy liver getting better because of a liver cleanse.

Liver detox may not necessarily be the best way to protect liver health. However, there are other ways that can help to protect it particularly through dietary measures. That said, below is a list of liver-friendly foods that you can add to your diet, boosting your bodys personal detoxing system.

Rich in antioxidants, green tea can do wonders for your health, and that includes your liver as well.

For instance, a Japanese study published in the British Medical Journal found a strong association between drinking 510 cups ofgreen teaper day and improved blood markers of liver health.

Additionally, separate research published in the International Journal of Molecular Medicine found that after drinking green tea for 12 weeks, patients with non-alcoholic fatty liver disease (NAFLD) noted an improvement in their liver enzyme levels. Researchers also noted that green tea may have helped to reduce oxidative stress and fat deposits in the liver.

Lastly, findings published in the Nutrition and Cancer journal revealed that drinking four or more cups a day of green tea can help to reduce your risk of developing liver cancer.

With that said, if youre looking to boost your liver health, its preferable to stick to buying green tea as opposed to green tea extracts. This is because some supplements have been found to damage the liver, as opposed to helping it.

A food group that consists of broccoli, cauliflower, brussels sprouts, and cabbage. These vegetables can help to boost liver health because they are rich in the compound glutathione.

While human studies are limited, animal studies have found that eating cruciferous vegetables may help the body remove toxins, and it may even slow down the progression of fatty liver disease in mice (1).

That said, a 2015 study published in the World Journal of Gastroenterology found that broccoli sprout extract helped to improve liver enzyme levels and decrease oxidative stress in men with fatty liver disease.

If youre looking for the ultimate snack food, then look no further than nuts. High in omega 3 fatty acids, as well as antioxidants and vitamin E, nuts are exactly what your health, and your liver, need.

For one, findings published in the World Journal of Gastroenterology found that, over a six-month period, 106 people with non-alcoholic fatty liver disease experienced improved levels of liver enzymes following their regular consumption of nuts.

Whats more, an observational study published in the Journal ofGastroenterologyandHepatology found a link between men who ate small amounts of nuts and seeds and an increased risk of developing NAFLD.

Olive oil is considered one of the best sources of healthy fat in the world, and this can help to benefit your liver.

Fat accumulation in the liver is one of the first signs of liver disease. That said, research published in the journal Diabetes Care found that consuming a teaspoon of olive oil a day helped not only improve liver enzymes, but also fat levels.

Berries, particularly the deep-hued ones like blueberries, blackberries, and raspberries, are rich in antioxidants known as polyphenols, and these plant compounds may help to protect the liver from damage.

According to an animal study published in the World Journal of Gastroenterology, the antioxidants commonly found in berries helped to slow down the development of scar tissue in the livers of rats.

Additionally, a test-tube study found in the Food Chemistry journal revealed that blueberry extract helped to inhibit the growth of human liver cancer cells.

Thats right. Believe it or not, your morning cup of coffee may be whats keeping your liver so healthy, as a result of its protective properties.

For instance, a study published in the Journal of Clinical Gastroenterologysuggested that coffee helps to reduce fat buildup in the liver. If thats not enough, the same study found that drinking coffee helps to lower the risk of permanent liver damage in people with chronic liver disease. Additionally, a separate study saw that drinking coffee can help reduce the risk of death in people with chronic liver disease (2).

As there are foods that can help to keep your liver healthy, there are also those that may affect its health. These include:

Your liver is a vital organ thats needed for various processes, in order to keep your body healthy. Now, while the efficiency of a traditional liver detox or cleanse is still up for debate, there are foods that can help protect its health.

Read the original post:
Liver Detox: 6 Foods To Boost and Cleanse Your Liver - Longevity LIVE

Read More...

FIFA 21: 10 Reasons To Be Worried – WhatCulture

February 15th, 2020 5:43 pm

Your enjoyment of FIFA 20 depended on your patience, longevity with the series and whether or not you do anything with the game other than open Ultimate Team packs.

It was just another year for EA's footy machine, but it didn't roll past without serious flak on YouTube and social media from angry gamers who demanded to know why everything was so stale. Bugs and glitches were popping up all over the place too, and the whole project became 2019's latest reminder that annual franchises might not be worth the cash every time they're pumped out onto store shelves.

At this stage, a year off would be a blessing. That's not going to happen though, and it leads many to worry about what FIFA 21 will bring. This will be the dawn of yet another new era for EA's uncompromising juggernaut, and they're not the only ones vying to make it special. Those who venture beyond FIFA's limits know there's stiff competition for the football gaming crown.

Start chewing those fingernails, FIFA lovers, because there are loads of reasons to fret about what 21 will be like...

Read the original:
FIFA 21: 10 Reasons To Be Worried - WhatCulture

Read More...

Why Bill Gates thinks gene editing and artificial intelligence could save the world – GeekWire

February 15th, 2020 5:42 pm

Microsoft co-founder Bill Gates makes a point during a Q&A with Margaret Hamburg, board chair for the American Association for the Advancement of Science. (GeekWire Photo / Alan Boyle)

Microsoft co-founder Bill Gates has been working to improve the state of global health through his nonprofit foundation for 20 years, and today he told the nations premier scientific gathering that advances in artificial intelligence and gene editing could accelerate those improvements exponentially in the years ahead.

We have an opportunity with the advance of tools like artificial intelligence and gene-based editing technologies to build this new generation of health solutions so that they are available to everyone on the planet. And Im very excited about this, Gates said in Seattle during a keynote address at the annual meeting of the American Association for the Advancement of Science.

Such tools promise to have a dramatic impact on several of the biggest challenges on the agenda for the Bill & Melinda Gates Foundation, created by the tech guru and his wife in 2000.

When it comes to fighting malaria and other mosquito-borne diseases, for example, CRISPR-Cas9 and other gene-editing tools are being used to change the insects genome to ensure that they cant pass along the parasites that cause those diseases. The Gates Foundation is investing tens of millions of dollars in technologies to spread those genomic changes rapidly through mosquito populations.

Millions more are being spent to find new ways fighting sickle-cell disease and HIV in humans. Gates said techniques now in development could leapfrog beyond the current state of the art for immunological treatments, which require the costly extraction of cells for genetic engineering, followed by the re-infusion of those modified cells in hopes that theyll take hold.

For sickle-cell disease, the vision is to have in-vivo gene editing techniques, that you just do a single injection using vectors that target and edit these blood-forming cells which are down in the bone marrow, with very high efficiency and very few off-target edits, Gates said. A similar in-vivo therapy could provide a functional cure for HIV patients, he said..

The rapid rise of artificial intelligence gives Gates further cause for hope. He noted that that the computational power available for AI applications has been doubling every three and a half months on average, dramatically improving on the two-year doubling rate for chip density thats described by Moores Law.

One project is using AI to look for links between maternal nutrition and infant birth weight. Other projects focus on measuring the balance of different types of microbes in the human gut, using high-throughput gene sequencing. The gut microbiome is thought to play a role in health issues ranging from digestive problems to autoimmune diseases to neurological conditions.

This is an area that needed these sequencing tools and the high-scale data processing, including AI, to be able to find the patterns, Gates said. Theres just too much going on there if you had to do it, say, with paper and pencil to understand the 100 trillion organisms and the large amount of genetic material there. This is a fantastic application for the latest AI technology.

Similarly, organs on a chip could accelerate the pace of biomedical research without putting human experimental subjects at risk.

In simple terms, the technology allows in-vitro modeling of human organs in a way that mimics how they work in the human body, Gates said. Theres some degree of simplification. Most of these systems are single-organ systems. They dont reproduce everything, but some of the key elements we do see there, including some of the disease states for example, with the intestine, the liver, the kidney. It lets us understand drug kinetics and drug activity.

The Gates Foundation has backed a number of organ-on-a-chip projects over the years, including one experiment thats using lymph-node organoids to evaluate the safety and efficacy of vaccines. At least one organ-on-a-chip venture based in the Seattle area, Nortis, has gone commercial thanks in part to Gates support.

High-tech health research tends to come at a high cost, but Gates argues that these technologies will eventually drive down the cost of biomedical innovation.

He also argues that funding from governments and nonprofits will have to play a role in the worlds poorer countries, where those who need advanced medical technologies essentially have no voice in the marketplace.

If the solution of the rich country doesnt scale down then theres this awful thing where it might never happen, Gates said during a Q&A with Margaret Hamburg, who chairs the AAAS board of directors.

But if the acceleration of medical technologies does manage to happen around the world, Gates insists that could have repercussions on the worlds other great challenges, including the growing inequality between rich and poor.

Disease is not only a symptom of inequality, he said, but its a huge cause.

Other tidbits from Gates talk:

Read Gates prepared remarks in a posting to his Gates Notes blog, or watch the video on AAAS YouTube channel.

Excerpt from:
Why Bill Gates thinks gene editing and artificial intelligence could save the world - GeekWire

Read More...

Twist Bioscience Pursues Growth at All Costs. How Long Will Investors Tolerate It? – Motley Fool

February 15th, 2020 5:42 pm

In recent years, promising start-ups have faced almost no obstacles to raising capital, so long as they pursued growth at all costs. Investors accepted significant losses in the present on the premise that these would translate to incredible market share in the future. The environment of easy money created many questionable valuations (see: WeWork), and even rare instances of outright fraud (see: Theranos).

But the market shifted in 2019. Investors are thinking more objectively about the stories presented by start-ups and emerging companies, and are much more interested in profitable growth, or at least progress toward it, than empty promises of a big payoff down the road.

While tech companies such as WeWork, Uber, Slack Technologies, and others have been hit by this newfound skepticism, even swearing off the growth-at-all-costs mantra of years past, the field of synthetic biology has yet to (publicly) face its reckoning. If and when it does, Twist Bioscience (NASDAQ:TWST) might be the first to fall.

Image source: Getty Images

Twist Bioscience wields the leading technology platform for synthesizing DNA, which can be used in genetic engineering experiments to create reference probes for DNA sequencing applications and to store digital data. The company is often associated with synthetic biology, or engineered biology, which is the intentional design of living technologies with reproducible functionality.

The company recently reported fiscal first-quarter 2020 operating results for the three-month period ending Dec. 31, and announced it had settled a long-standing legal dispute with Agilent Technologies. The settlement avoided a costly jury trial, but cost the synthetic DNA pioneer $22.5 million. Investors were just pleased to be rid of the headache, and to have removed the largest source of uncertainty hanging over the stock. Shares soared on the announcement.

The immediate interpretation of this event is that the settlement will allow Twist Bioscience and Wall Street to focus entirely on growth and financial performance. A deeper dive, however, suggests investors might want to be careful what they wish for.

While the company touts impressive growth in revenue and gross profit, that means little when losses attributed to shareholders are growing even faster in absolute dollar amounts. Operating losses have now grown sequentially for eight consecutive quarters.

Metric

Fiscal Q1 2020

Fiscal Q1 2019

Change (YoY)

Revenue

$17.2 million

$11.5 million

49%

Gross profit

$3.3 million

($0.4 million)

N/A

Operating expenses

$59.2 million

$22.5 million

163%

Operating expenses excluding Agilent settlement

$36.7 million

$22.5 million

63%

Operating income

($55.8 million)

($22.9 million)

N/A

Operating income excluding Agilent settlement

($33.3 million)

($22.9 million)

N/A

Data source: Twist Bioscience press release. YoY = Year over Year.

When the Agilent legal settlement is excluded, normal day-to-day operations resulted in fiscal first-quarter 2020 operating expenses of $36.7 million. That was $14.2 million greater than in the year-ago period, which easily offset the $3.7 million improvement in gross profit in that span.

Swelling losses have had a real impact on shareholders: dilution. Twist Bioscience has tapped into the public markets multiple times since conducting its initial public offering (IPO) in late 2018, including an offering in late January that raised $48.2 million in net proceeds. Investors now know that was largely conducted to pay for the Agilent legal settlement, which will consume roughly half of the proceeds.

In a little over 15 months as a publicly traded company, multiple stock offerings from Twist Bioscience have increased the number of shares outstanding from 26.6 million to 35.4 million. That's an increase of 33%. Considering the business reported $103 million in cash at the end of December and expects to report a net loss of at least $129.5 million in fiscal 2020, investors should expect additional public stock offerings or convertible debt offerings -- and, therefore, additional dilution -- in the near future.

It might be tempting to think the company could just flip a switch and focus on profitable growth, but a closer look at SEC filings suggests that might not be possible.

Image source: Getty Images

Investors know Twist Bioscience as the company that makes synthetic DNA. It serves industrial and pharmaceutical customers that require (relatively) large amounts of DNA for high-throughput genetic engineering research. It's by far the best in the industry -- even supplying some of its competitors.

However, most of the company's growth and profits come from an entirely different market: next-generation sequencing (NGS) tools. In fact, NGS tools are expected to generate nearly as much revenue in fiscal 2020 as synthetic genes. It's a bit ironic that the company known for writing DNA is increasingly dependent on companies that read DNA, but there are two primary reasons for that.

First, despite all of the hype, the market for synthetic DNA is simply not very large and isn't very profitable (if it's profitable at all). Roughly 25% of the company's synthetic gene revenue in fiscal 2020 will come from a single customer. It's also worth noting that the business didn't begin generating gross profit until it ramped up sales of NGS tools.

Second, Twist Bioscience's technology platform is well suited for designing NGS tools. The company uses its ability to synthesize accurate DNA sequences to create high-quality target enrichment probes, which allow researchers to detect specific genetic sequences in biological samples.

But investors cannot conflate early success in the NGS market with being on the path to profitability. Sales of target enrichment probes are far from sufficient to offset losses from the remainder of the business. The company expects roughly half of fiscal full-year 2020 revenue to come from money-losing or low-margin products related to synthetic genes; the other half will comprise NGS tools.

Revenue Category

Fiscal Full-Year 2020 Revenue Guidance

Fiscal Full-Year 2019 Revenue, Actual

Change (YoY)

Synthetic genes and related products

$42 million to $43 million

$33.3 million

26% to 29%

NGS tools

$37 million to $40 million

$21.0 million

67% to 76%

Biopharma collaboration

$1 million

N/A

N/A

Total revenue

$80 million to $84 million

$54.4 million

47% to 54%

Data source: Twist Bioscience. YoY = Year over Year.

Despite impressive revenue growth, Twist Bioscience expects to report a net loss of at least $107 million from day-to-day operations in the current fiscal year. That's exactly the same net loss reported in fiscal 2019, and it jumps to at least $129.5 million when the Agilent legal settlement is included.

That also suggests that Twist Bioscience might be stuck financially for the foreseeable future. In order toremain relevant in a money-losing market for synthetic genes and a very competitive market for NGS tools, it must spend significant sums of money on sales and marketing expenses, which are the main driver of operating losses.

In other words, although NGS products are responsible for most of the company's gross profit, they're also responsible for much of the company's operating losses. If the company stopped marketing its products as heavily in an attempt to pare losses, then it might not grow quickly enough to achieve breakeven operations. That suggests Twist Bioscience is pursuing growth at all costs because it doesn't really have any other options. That's not a very secure position for individual investors.

Image source: Getty Images

Investors might be drawn to Twist Bioscience because of its industry-leading technology platform for synthesizing DNA. It can create products today for high-throughput genetic engineering experiments or NGS tools, while tomorrow's opportunities could span digital data storage in DNA or rational design of biologic drugs.

But, to be blunt, publicly traded synthetic biology companies have a downright awful track record of living up to their lofty promises. The best product from the field to date has been hype, and that's led to terrible outcomes for individual investors who invested on storytelling alone. Shares of Twist Bioscience have rewarded investors with solid gains since the IPO, but swelling losses make it reasonable to question if and when the sentiment will turn negative.

Continued here:
Twist Bioscience Pursues Growth at All Costs. How Long Will Investors Tolerate It? - Motley Fool

Read More...

Key findings about Americans’ confidence in science and their views on scientists’ role in society – Pew Research Center

February 15th, 2020 5:42 pm

(KTSDESIGN/Science Photo Library)

Science issues whether connected with climate, childhood vaccines or new techniques in biotechnology are part of the fabric of civic life, raising a range of social, ethical and policy issues for the citizenry. As members of the scientific community gather at the annual meeting of the American Association for the Advancement of Science (AAAS) this week, here is a roundup of key takeaways from our studies of U.S. public opinion about science issues and their effect on society. If youre on Twitter, follow @pewscience for more science findings.

The data for this post was drawn from multiple different surveys. The most recent was a survey of 3,627 U.S. adults conducted Oct. 1 to Oct. 13, 2019. This post also draws on data from surveys conducted in January 2019, December 2018, April-May 2018 and March 2016. All surveys were conducted using the American Trends Panel (ATP), an online survey panel that is recruited through national, random sampling of residential addresses. This way nearly all U.S. adults have a chance of being selected. The survey is weighted to be representative of the U.S. adult population by gender, race, ethnicity, education and other categories. Read more about the ATPs methodology.

Following are the questions and responses for surveys used in this post, as well as each surveys methodology:

1Some public divides over science issues are aligned with partisanship, while many others are not. Science issues can be a key battleground for facts and information in society. Climate science has been part of an ongoing discourse around scientific evidence, how to attribute average temperature increases in the Earths climate system, and the kinds of policy actions needed. While public divides over climate and energy issues are often aligned with political party affiliation, public attitudes on other science-related issues are not.

For example, there are differences in public beliefs around the risks and benefits of childhood vaccines. Such differences arise amid civic debates about the spread of false information about vaccines. While such beliefs have important implications for public health, they are not particularly political in nature.

In fact, Republicans and independents who lean to the GOP are just as likely as Democrats and independents who lean to the Democratic Party to say that, overall, the benefits of the measles, mumps and rubella vaccine outweigh the risks (89% and 88% respectively).

2Americans have differing views about some emerging scientific and technological developments. Scientific and technological developments are a key source of innovation and, therefore, change in society. Pew Research Center studies have explored public reactions to emergent developments from genetic engineering techniques, automation and more. One field at the forefront of public reaction is the use of gene editing of babies or genetic engineering of animals. Americans have mixed views over whether the use of gene editing to reduce a babys risk of serious disease that could occur over their lifetime is appropriate (60%) or is taking medical technology too far (38%), according to a 2018 survey. Similarly, about six-in-ten Americans (57%) said that genetic engineering of animals to grow organs or tissues for humans needing a transplant would be appropriate, while four-in-ten (41%) said it would be taking technology too far.

When we asked Americans about a future where a brain chip implant would give otherwise healthy individuals much improved cognitive abilities, a 69% majority said they were very or somewhat worried about the possibility. By contrast, about half as many (34%) were enthusiastic. Further, as people think about the effects of automation technologies in the workplace, more say automation has brought more harm than help to American workers.

One theme running through our findings on emerging science and technology is that public hesitancy often is tied to concern about the loss of human control, especially if such developments would be at odds with personal, religious and ethical values. In looking across seven developments related to automation and the potential use of biomedical interventions to enhance human abilities, Center studies found that proposals that would increase peoples control over these technologies were met with greater acceptance.

3Most in the U.S. see net benefits from science for society, and they expect more ahead. About three-quarters of Americans (73%) say science has, on balance, had a mostly positive effect on society. And 82% expect future scientific developments to yield benefits for society in years to come.

The overall portrait is one of strong public support for the benefits of science to society, though the degree to which Americans embrace this idea differs sizably by race and ethnicity as well as by levels of science knowledge.

Such findings are in line with those of the General Social Survey on the effects of scientific research. In 2018, about three-quarters of Americans (74%) said the benefits of scientific research outweigh any harmful results. Support for scientific research by this measure has been roughly stable since the 1980s.

4The share of Americans with confidence in scientists to act in the public interest has increased since 2016.

Public confidence in scientists to act in the public interest tilts positive and has increased over the past few years. As of 2019, 35% of Americans report a great deal of confidence in scientists to act in the public interest, up from 21% in 2016.

About half of the public (51%) reports a fair amount of confidence in scientists, and just 13% have not too much or no confidence in this group to act in the public interest.

Public trust in scientists by this measure stands in contrast to that for other groups and institutions. One of the hallmarks of the current times has been low trust in government and other institutions. One-in-ten or fewer say they have a great deal of confidence in elected officials (4%) or the news media (9%) to act in the public interest.

5Americans differ over the role and value of scientific experts in policy matters. While confidence in scientists overall tilts positive, peoples perspectives about the role and value of scientific experts on policy issues tends to vary. Six-in-ten U.S. adults believe that scientists should take an active role in policy debates about scientific issues, while about four-in-ten (39%) say, instead, that scientists should focus on establishing sound scientific facts and stay out of such debates.

Democrats are more inclined than Republicans to think scientists should have an active role in science policy matters. Indeed, most Democrats and Democratic-leaning independents (73%) hold this position, compared with 43% of Republicans and GOP leaners.

More than four-in-ten U.S. adults (45%) say that scientific experts usually make better policy decisions than other people, while a similar share (48%) says such decisions are neither better nor worse than other peoples and 7% say scientific experts decisions are usually worse than other peoples.

Here, too, Democrats tend to hold scientific experts in higher esteem than do Republicans: 54% of Democrats say scientists policy decisions are usually better than those of other people, while two-thirds of Republicans (66%) say that scientists decisions are either no different from or worse than other peoples.

6Factual knowledge alone does not explain public confidence in the scientific method to produce sound conclusions. Overall, a 63% majority of Americans say the scientific method generally produces sound conclusions, while 35% think it can be used to produce any result a researcher wants. Peoples level of knowledge can influence beliefs about these matters, but it does so through the lens of partisanship, a tendency known as motivated reasoning.

Beliefs about this matter illustrate that science knowledge levels sometimes correlate with public attitudes. But partisanship has a stronger role.

Democrats are more likely to express confidence in the scientific method to produce accurate conclusions than do Republicans, on average. Most Democrats with high levels of science knowledge (86%, based on an 11-item index of factual knowledge questions) say the scientific method generally produces accurate conclusions. By comparison, 52% of Democrats with low science knowledge say this. But science knowledge has little bearing on Republicans beliefs about the scientific method.

7Trust in practitioners like medical doctors and dietitians is stronger than that for researchers in these fields, but skepticism about scientific integrity is widespread. Scientists work in a wide array of fields and specialties. A 2019 Pew Research Center survey found public trust in medical doctors and dietitians to be higher than that for researchers working in these areas. For example, 48% of U.S. adults say that medical doctors give fair and accurate information all or most of the time. By comparison, 32% of U.S. adults say the same about medical research scientists. And six-in-ten Americans say dietitians care about their patients best interests all or most of the time, while about half as many (29%) say this about nutrition research scientists with the same frequency.

One factor in public trust of scientists is familiarity with their work. For example, people who were more familiar with what medical science researchers do were more trusting of these researchers to express care or concern for the public interest, to do their job with competence and to provide fair and accurate information. Familiarity with the work of scientists was related to trust for all six specialties we studied.

But when it comes to questions of scientists transparency and accountability, most Americans are skeptical. About two-in-ten or fewer U.S. adults say that scientists are transparent about potential conflicts of interest with industry groups all or most of the time. Similar shares (roughly between one-in-ten and two-in-ten) say that scientists admit their mistakes and take responsibility for them all or most of the time.

This data shows clearly that when it comes to questions of transparency and accountability, most in the general public are attuned to the potential for self-serving interests to skew science findings and recommendations. These findings echo calls for increased transparency and accountability across many sectors and industries today.

8What boosts public trust in scientific research findings? Most say its making data openly available. A 57% majority of Americans say they trust scientific research findings more when the data is openly available to the public. And about half of the U.S. public (52%) say they are more likely to trust research that has been independently reviewed.

The question of who funds the research is also consequential for how people think about scientific research. A 58% majority say they have lower trust when research is funded by an industry group. By comparison, about half of Americans (48%) say government funding for research has no particular effect on how much they trust the findings; 28% say this decreases their trust and 23% say it increases their trust.

Originally posted here:
Key findings about Americans' confidence in science and their views on scientists' role in society - Pew Research Center

Read More...

The Use of Immunotherapy in Blood Cancer Treatment – Curetoday.com

February 15th, 2020 5:42 pm

Lee Greenberger, chief scientific officer at the Leukemia and Lymphoma Society, discusses the use of immunotherapy in blood cancer treatment.

BY Kristie L. Kahl and Lee Greenberger

Transcript:

Kristie L. Kahl: Can you give us a background on what immunotherapy is and how it works?

Lee Greenberger: Immunotherapy has a long history in blood cancer. It goes all the way back to transplantations where you take the immune cells from one patient and put it into the other. It actually can end up being curative in that transplant situation. We now know the molecular basis of that, and immunotherapy has evolved considerably, specifically in the last 10 years where we have sort of brought it out of the lab and now moving it forward.

The story begins with monoclonal antibodies and (Rituxan [rituximab]), which is a monoclonal antibody to CD20, which sits on the surface of tumor cells. It was one of the first antibodies approved, along with (Herceptin [trastuzumab]) for breast cancer. Rituxan is used for blood cancers and used widely. So, the concept that you can make antibodies in the laboratory, manufacture them, bring them out to patients and it has shown that it is highly effective in multiple lymphomas. Since that time, there are multiple antibodies that have come out.

Beyond that, in the last 10 years in particular, we now know that there are all sorts of mechanisms control the immune system, and in fact, the immune system is highly effective at getting rid of tumor cells. For example, in the late 1980s, there was an investigator in Israel who figured out how to actually manufacture from scratch, a gene and put it into T cells, which would allow the T cells, which are part of the immune system, to home on the tumor cells and kill those cells. That evolved into something called chimeric antigen receptor-therapy, or CAR-T. CAR-T has gone through multiple evolutions, but there are now two CAR-T products on the market, and basically what this is a genetic engineering of the T cells.

You take the T cells out of the patient, genetically engineer that gene, put it into those T cells, and now that T cell can home on the tumor cell. When it arrives at the tumor cell, it is recognizing something very specific on those tumor cells. It will dramatically expand. So, instead of having one T cell, now youll have a million cells. And those cells can very effectively kill tumor cells for certain patients. For example, its been used very effectively in children with B-cell type leukemia. Its also used in certain types of lymphoma, most notably diffuse large B cell lymphoma and recently mantle cell lymphoma.

So, thats one type. The cells have to come out of the patient. Manufacturing takes about 14-21 days, and put back into the patient. That can be a very effective solution for treating patients with relapsed disease.

Along with CAR-T cell therapy, there is bi-specific antibodies. These are antibodies that are capable of taking the T cells of the patient and making them recognize the tumor cells. So, instead of a linker that will move these cells together, hence the notion of bi-specific: one to the tumor cells, one to the T cells, bring them together and it makes the T cells capable of killing the tumor cells.

You also have antibody drug conjugates. In that case, you take an antibody which is going to home in on the surface of the tumor cells, and you link it to a toxin. This technology is actually quite fascinating because it actually grew up about the same time that monoclonal antibodies were developed. We had a bunch of super toxins discovered from products. They were so toxic they couldnt even be used by themselves, but if you take that toxin and link it to an antibody, now you have a guided missile. The antibody arrives at the tumor cell, brings the toxin into the tumor cell. Antibody drug conjugates have been on the market since the late 1990s.

Bottom line is, the reason why immunotherapy is so attractive is because it specifically homes on the tumor cell, its highly effective at killing the tumor cell, and it doesnt have some of the harsh, toxic side effects that cytotoxic drugs typically do. Thats not to say they are devoid of toxicity, but its of a different nature and it in general can be managed well.

Kristie L. Kahl: What are some of the more notable side effects?

Lee Greenberger: For CAR-T cell therapy, which is among the most advanced, you get something called cytokine release syndrome. These T cells basically become so revved up, that they secrete a lot of cytokine products that can make you feel ill, cause fever, and in rare cases can be lethal if you cant control them. So, they can compromise organs. Physicians nowadays with CAR-T cell therapy are well aware of some of these cytokine release syndrome (symptoms). They tend to appear a few days after therapy, and dont last for very long but you have to recognize that theyre there. Its a very common event for CAR-T cell therapy. Were getting better at these things. They used to be grade 3, which is serious, now some of the new CAR-T cell therapies are having low-grade (side effects), which do not require observation.

Neurotoxicity is another, where the patient may be disoriented. This also comes up as the T cell numbers increase dramatically, the neurotoxicity could manifest as confusion, disorientation, and then it will die away over time, generally over a couple of weeks.

So, those are two things to watch out for for CAR-T cell therapy. Theyre manageable, but it can be of a serious nature.

Kristie L. Kahl: How does the multidisciplinary approach play a role?

Lee Greenberger:CAR-T cell therapy requires the involvement of many people in the treatment. There are cells that have to come out of the patient, where you take the blood out of the patient and harvest the cells, so there are technicians involved harvesting the cells. Then they go out to a laboratory, and they will make them in their labs. The cells go back into the patient, and that requires careful observation, typically for the next week after you get these cells. This can require an in-hospital stay or outpatient. It requires a physician overseeing it, nurses who are qualified to recognize some of the early symptoms, careful monitoring. We can monitor these things because we know we have biomarkers to know how aggressive these T cells are expanding. So, for example, for cytokine release syndrome, IL6 levels can shoot way high. So, if you are analyzing the blood, and can get these results back quickly, we now have therapies to knock down the IL6 levels and block those effects.

Kristie L. Kahl: What are some questions patients can ask their doctors so that they can become better informed about their treatment decisions?

Lee Greenberger: The road to treating these blood cancers is actually a long, involved road. In some cases, some blood cancers require watch-and-wait and we dont do anything. In other cases, a newly diagnosed patient will begin to get treatment, which depends on (the type of blood cancer). The treatments are all quite different. In some of those cases, the initial treatment will keep the patient in check for years. Dont forget that many of these blood cancers happen in older patients (60-70 years old). So, if you can keep the disease in check for 20 years, youre doing fine. In other cases, these lymphomas will come back. Even with CAR-T therapy, where we can control the disease long-term as best as we can, we can expect that a certain number of these patients, the disease will return. So, with relapsed or refractory disease, these are the ones that are going to require additional treatments.

Transcript Edited for Clarity

Link:
The Use of Immunotherapy in Blood Cancer Treatment - Curetoday.com

Read More...

Public fears and anxieties over GMOs growing old – The Duquesne Duke

February 15th, 2020 5:42 pm

2/13/20

Hannah Boucher | Staff Columnist

Mass-produced bananas are dying at an increasingly faster rate and are at risk of one day going extinct.

Genetically modified organisms (GMOs) are not as new of a concept as many would like to believe. While it has been a controversial scientific advancement since the 1970s, when Herbert Boyer and Stanley Cohen invented modern-day genetic engineering, artificial selection has been used to cultivate crops and animals for over 30,000 years.

The misconception that GMOs are dangerous has derived from a misunderstanding of the definition. In fact, agriculture exists because humans selectively bred organisms to cater to their needs. This is the definition of agriculture.

Genetic engineering the true controversial topic falls under the umbrella of genetic modification, which is what has brought society its big, red tomatoes, giant ears of yellow corn and sweet bananas.

The technology used to genetically engineer common produce can also be used on animals and bacteria. Cloning and gene transfer have been successfully carried out in scientific labs, however, these successes have been met with much concern.

While humans possess the power to multiply livestock by the masses, or create an entirely new species in a lab, that does not mean it should be done. These processes violate certain ethical standards because they are seen as being humane which is technically true.

An example of this issue is the banana industry. The Cavendish banana which is actually the second species commercially grown fell victim to Panama disease, a fungus that spreads quickly and kills the entire plant. Bananas are mass produced by corporations such as Dole and Chiquita to appeal to the millions but at a cost.

Scientists are struggling to find a banana plant that carries the gene that fights the disease to breed with the Cavendish. Banana plants are now dying at a faster rate than can be produced, meaning that they may go extinct. This is not the first occurrence of this issue either. In the 1950s, the first species of banana, the Gros Michael, was completely wiped out from a strain of the Panama disease.

The main difference between normal cultivation and monoculture is that monoculture decreases the variability within a population. Cultivation has been successfully practiced for thousands of years. Some of the most commonly consumed vegetables are actually all derived from the same species. Broccoli, cabbage, kale, brussel sprouts and a few other popular greens are all cultivated forms of Brassica oleracea, or, wild cabbage.

Although there are major risks associated with selective breeding, there are also major benefits. By selective the most favorable traits within a species, the fitness, or the species ability to produce viable offspring, increases.

This has helped the farming industry keep up with the growing pool of consumers that continues to increase as the population rises. Certain modifications reduce the need for pesticides and increase the overall crop yield, which also increases the overall income for farmers.

Another big issue with GMOs is that not all of the health risks are currently known. Before any new modified products are released to consumers, they must undergo a series of tests assessing the possible hazards posed from consumption. However, the regulations put in place by the Center for Food Safety [CFS] require all products that contain genetically engineered ingredients to be clearly labeled so people are aware of its contents.

It is important to consider though that many technological advancements pose risks to the general public. It is not the act of genetically manipulating an organism that is the problem, but rather the lack of consideration of the possible issues. Scientists must be careful not to cross a line because they hold the fate of species in their hands. There is nothing to fear when it comes to GMOs. Civilization would be nonexistent without the cultivation of crops and animals.

Related

Visit link:
Public fears and anxieties over GMOs growing old - The Duquesne Duke

Read More...

Have humans evolved beyond nature? – The Independent

February 15th, 2020 5:42 pm

Such is the extent of our dominion on Earththat the answers to questions around whether we are still part of nature and whether we even need some of it rely on an understanding of what we want as Homo sapiens. And to know what we want, we need to grasp what we are.

It is a huge question but they are the best. And as a biologist, here is my humble suggestion to address it, and a personal conclusion. You may have a different one, but what matters is that we reflect on it.

Perhaps the best place to start is to consider what makes us human in the first place, which is not as obvious as it may seem.

Sharing the full story, not just the headlines

Many years ago, a novel written by Vercors called Les Animaux Dnaturs (Denatured Animals) told the story of a group of primitive hominids, the Tropis, found in an unexplored jungle in New Guinea, who seem to constitute a missing link. However, the prospect that this fictional group may be used as slave labour by an entrepreneurial businessman named Vancruysen forces society to decide whether the Tropis are simply sophisticated animals or whether they should be given human rights. And herein lies the difficulty.

Human status had hitherto seemed so obvious that the book describes how it is soon discovered that there is no definition of what a human actually is. Certainly, the string of experts consulted anthropologists, primatologists, psychologists, lawyers and clergymen could not agree. Perhaps prophetically, it is a layperson who suggested a possible way forward.

She asked whether some of the hominids habits could be described as the early signs of a spiritual or religious mind. In short, were there signs that, like us, the Tropis were no longer at one with nature, but had separated from it, and were now looking at it from the outside with some fear.

Pluto has a 'beating heart' of frozen nitrogen that is doing strange things to its surface, Nasa has found.The mysterious core seems to be the cause of features on its surface that have fascinated scientists since they were spotted by Nasa's New Horizons mission."Before New Horizons, everyone thought Pluto was going to be a netball - completely flat, almost no diversity," said Tanguy Bertrand, an astrophysicist and planetary scientist at NASA's Ames Research Center and the lead author on the new study."But it's completely different. It has a lot of different landscapes and we are trying to understand what's going on there."

Getty

The ancient invertabrate worm-like species rhenopyrgus viviani (pictured) is one of over 400 species previously unknown to science that were discovered by experts at the Natural History Museum this year

PA

Jackdaws can identify dangerous humans from listening to each others warning calls, scientists say. The highly social birds will also remember that person if they come near their nests again, according to researchers from the University of Exeter. In the study, a person unknown to the wild jackdaws approached their nest. At the same time scientists played a recording of a warning call (threatening) or contact calls (non-threatening). The next time jackdaws saw this same person, the birds that had previously heard the warning call were defensive and returned to their nests more than twice as quickly on average.

Getty

The sex of the turtle is determined by the temperatures at which they are incubated. Warm temperatures favour females.But by wiggling around the egg, embryos can find the Goldilocks Zone which means they are able to shield themselves against extreme thermal conditions and produce a balanced sex ratio, according to the new study published in Current Biology journal

Ye et al/Current Biology

African elephant poaching rates have dropped by 60 per cent in six years, an international study has found. It is thought the decline could be associated with the ivory trade ban introduced in China in 2017.

Reuters

Scientists have identified a four-legged creature with webbed feet to be an ancestor of the whale. Fossils unearthed in Peru have led scientists to conclude that the enormous creatures that traverse the planets oceans today are descended from small hoofed ancestors that lived in south Asia 50 million years ago

A. Gennari

A scientist has stumbled upon a creature with a transient anus that appears only when it is needed, before vanishing completely. Dr Sidney Tamm of the Marine Biological Laboratory could not initially find any trace of an anus on the species. However, as the animal gets full, a pore opens up to dispose of waste

Steven G Johnson

Feared extinct, the Wallace's Giant bee has been spotted for the first time in nearly 40 years. An international team of conservationists spotted the bee, that is four times the size of a typical honeybee, on an expedition to a group of Indonesian Islands

Clay Bolt

Fossilised bones digested by crocodiles have revealed the existence of three new mammal species that roamed the Cayman Islands 300 years ago. The bones belonged to two large rodent species and a small shrew-like animal

New Mexico Museum of Natural History

Scientists at the University of Maryland have created a fabric that adapts to heat, expanding to allow more heat to escape the body when warm and compacting to retain more heat when cold

Faye Levine, University of Maryland

A study from the University of Tokyo has found that the tears of baby mice cause female mice to be less interested in the sexual advances of males

Getty

The Intergovernmental Panel on Climate Change has issued a report which projects the impact of a rise in global temperatures of 1.5 degrees Celsius and warns against a higher increase

Getty

The nobel prize for chemistry has been awarded to three chemists working with evolution. Frances Smith is being awarded the prize for her work on directing the evolution of enzymes, while Gregory Winter and George Smith take the prize for their work on phage display of peptides and antibodies

Getty/AFP

The nobel prize for physics has been awarded to three physicists working with lasers. Arthur Ashkin (L) was awarded for his "optical tweezers" which use lasers to grab particles, atoms, viruses and other living cells. Donna Strickland and Grard Mourou were jointly awarded the prize for developing chirped-pulse amplification of lasers

Reuters/AP

The Ledumahadi Mafube roamed around 200 million years ago in what is now South Africa. Recently discovered by a team of international scientists, it was the largest land animal of its time, weighing 12 tons and standing at 13 feet. In Sesotho, the South African language of the region in which the dinosaur was discovered, its name means "a giant thunderclap at dawn"

Viktor Radermacher / SWNS

Scientists have witnessed the birth of a planet for the first time ever. This spectacular image from the SPHERE instrument on ESO's Very Large Telescope is the first clear image of a planet caught in the very act of formation around the dwarf star PDS 70. The planet stands clearly out, visible as a bright point to the right of the center of the image, which is blacked out by the coronagraph mask used to block the blinding light of the central star.

ESO/A. Mller et al

Layers long thought to be dense, connective tissue are actually a series of fluid-filled compartments researchers have termed the interstitium. These compartments are found beneath the skin, as well as lining the gut, lungs, blood vessels and muscles, and join together to form a network supported by a mesh of strong, flexible proteins

Getty

Working in the Brazilian state of Mato Grosso, a team led by archaeologists at the University of Exeter unearthed hundreds of villages hidden in the depths of the rainforest. These excavations included evidence of fortifications and mysterious earthworks called geoglyphs

Jos Iriarte

More than one in 10 people were found to have traces of class A drugs on their fingers by scientists developing a new fingerprint-based drug test.Using sensitive analysis of the chemical composition of sweat, researchers were able to tell the difference between those who had been directly exposed to heroin and cocaine, and those who had encountered it indirectly.

Getty

The storm bigger than the Earth, has been swhirling for 350 years. The image's colours have been enhanced after it was sent back to Earth.

Pictures by: Tom Momary

Pluto has a 'beating heart' of frozen nitrogen that is doing strange things to its surface, Nasa has found.The mysterious core seems to be the cause of features on its surface that have fascinated scientists since they were spotted by Nasa's New Horizons mission."Before New Horizons, everyone thought Pluto was going to be a netball - completely flat, almost no diversity," said Tanguy Bertrand, an astrophysicist and planetary scientist at NASA's Ames Research Center and the lead author on the new study."But it's completely different. It has a lot of different landscapes and we are trying to understand what's going on there."

Getty

The ancient invertabrate worm-like species rhenopyrgus viviani (pictured) is one of over 400 species previously unknown to science that were discovered by experts at the Natural History Museum this year

PA

Jackdaws can identify dangerous humans from listening to each others warning calls, scientists say. The highly social birds will also remember that person if they come near their nests again, according to researchers from the University of Exeter. In the study, a person unknown to the wild jackdaws approached their nest. At the same time scientists played a recording of a warning call (threatening) or contact calls (non-threatening). The next time jackdaws saw this same person, the birds that had previously heard the warning call were defensive and returned to their nests more than twice as quickly on average.

Getty

The sex of the turtle is determined by the temperatures at which they are incubated. Warm temperatures favour females.But by wiggling around the egg, embryos can find the Goldilocks Zone which means they are able to shield themselves against extreme thermal conditions and produce a balanced sex ratio, according to the new study published in Current Biology journal

Ye et al/Current Biology

African elephant poaching rates have dropped by 60 per cent in six years, an international study has found. It is thought the decline could be associated with the ivory trade ban introduced in China in 2017.

Reuters

Scientists have identified a four-legged creature with webbed feet to be an ancestor of the whale. Fossils unearthed in Peru have led scientists to conclude that the enormous creatures that traverse the planets oceans today are descended from small hoofed ancestors that lived in south Asia 50 million years ago

A. Gennari

A scientist has stumbled upon a creature with a transient anus that appears only when it is needed, before vanishing completely. Dr Sidney Tamm of the Marine Biological Laboratory could not initially find any trace of an anus on the species. However, as the animal gets full, a pore opens up to dispose of waste

Steven G Johnson

Feared extinct, the Wallace's Giant bee has been spotted for the first time in nearly 40 years. An international team of conservationists spotted the bee, that is four times the size of a typical honeybee, on an expedition to a group of Indonesian Islands

Clay Bolt

Fossilised bones digested by crocodiles have revealed the existence of three new mammal species that roamed the Cayman Islands 300 years ago. The bones belonged to two large rodent species and a small shrew-like animal

New Mexico Museum of Natural History

Scientists at the University of Maryland have created a fabric that adapts to heat, expanding to allow more heat to escape the body when warm and compacting to retain more heat when cold

Faye Levine, University of Maryland

A study from the University of Tokyo has found that the tears of baby mice cause female mice to be less interested in the sexual advances of males

Getty

The Intergovernmental Panel on Climate Change has issued a report which projects the impact of a rise in global temperatures of 1.5 degrees Celsius and warns against a higher increase

Getty

The nobel prize for chemistry has been awarded to three chemists working with evolution. Frances Smith is being awarded the prize for her work on directing the evolution of enzymes, while Gregory Winter and George Smith take the prize for their work on phage display of peptides and antibodies

Getty/AFP

The nobel prize for physics has been awarded to three physicists working with lasers. Arthur Ashkin (L) was awarded for his "optical tweezers" which use lasers to grab particles, atoms, viruses and other living cells. Donna Strickland and Grard Mourou were jointly awarded the prize for developing chirped-pulse amplification of lasers

Reuters/AP

The Ledumahadi Mafube roamed around 200 million years ago in what is now South Africa. Recently discovered by a team of international scientists, it was the largest land animal of its time, weighing 12 tons and standing at 13 feet. In Sesotho, the South African language of the region in which the dinosaur was discovered, its name means "a giant thunderclap at dawn"

Viktor Radermacher / SWNS

Scientists have witnessed the birth of a planet for the first time ever. This spectacular image from the SPHERE instrument on ESO's Very Large Telescope is the first clear image of a planet caught in the very act of formation around the dwarf star PDS 70. The planet stands clearly out, visible as a bright point to the right of the center of the image, which is blacked out by the coronagraph mask used to block the blinding light of the central star.

ESO/A. Mller et al

Layers long thought to be dense, connective tissue are actually a series of fluid-filled compartments researchers have termed the interstitium. These compartments are found beneath the skin, as well as lining the gut, lungs, blood vessels and muscles, and join together to form a network supported by a mesh of strong, flexible proteins

Getty

Working in the Brazilian state of Mato Grosso, a team led by archaeologists at the University of Exeter unearthed hundreds of villages hidden in the depths of the rainforest. These excavations included evidence of fortifications and mysterious earthworks called geoglyphs

Jos Iriarte

More than one in 10 people were found to have traces of class A drugs on their fingers by scientists developing a new fingerprint-based drug test.Using sensitive analysis of the chemical composition of sweat, researchers were able to tell the difference between those who had been directly exposed to heroin and cocaine, and those who had encountered it indirectly.

Getty

The storm bigger than the Earth, has been swhirling for 350 years. The image's colours have been enhanced after it was sent back to Earth.

Pictures by: Tom Momary

It is a telling perspective. Our status as altered or denatured animals creatures who have arguably separated from the natural world is perhaps both the source of our humanity and the cause of many of our troubles. In the words of the books author:

All mans troubles arise from the fact that we do not know what we are and do not agree on what we want to be

We will probably never know the timing of our gradual separation from nature although cave paintings perhaps contain some clues. But a key recent event in our relationship with the world around us is as well documented as it was abrupt. It happened on a sunny Monday morning, at precisely 8.15am.

A new age

Only the best news in your inbox

The atomic bomb that rocked Hiroshima on 6 August 1945 was a wake-up call so loud that it still resonates in our consciousness many decades later.

The day the sun rose twice was not only a forceful demonstration of the new era that we had entered buta reminder of how paradoxically primitive we remained: differential calculus, advanced electronics and almost godlike insights into the laws of the universe helped build, well a very big stick. Modern Homo sapiens seemingly had developed the powers of gods, while keeping the psyche of a stereotypical Stone Age killer.

We were no longer fearful of nature, but of what we would do to it, and ourselves. In short, we still did not know where we came from but began panicking about where we were going. We now know a lot more about our origins but we remain unsure about what we want to be in the future or, increasingly, as the climate crisis accelerates, whether we even have one.

Arguably, the greater choices granted by our technological advances make it even more difficult to decide which of the many paths to take. This is the cost of freedom. I am not arguing against our dominion over nature nor, even as a biologist, do I feel a need to preserve the status quo. Big changes are part of our evolution. After all, oxygen was first a poison which threatened the very existence of early life, yet it is now the fuel vital to our existence.

Similarly, we may have to accept that what we do, even our unprecedented dominion, is a natural consequence of what we have evolved into, and by a process nothing less natural than natural selection itself. If artificial birth control is unnatural, so is reduced infant mortality.

I am also not convinced by the argument against genetic engineering on the basis that it is unnatural. By artificially selecting specific strains of wheat or dogs, we had been tinkering more or less blindly with genomes for centuries before the genetic revolution. Even our choice of romantic partner is a form of genetic engineering. Sex is natures way of producing new genetic combinations quickly.

Even nature, it seems, can be impatient with itself.

Changing our world

Continue reading here:
Have humans evolved beyond nature? - The Independent

Read More...

Biologists rush to re-create the China coronavirus from its DNA code – MIT Technology Review

February 15th, 2020 5:42 pm

The world is watching with alarm as China struggles to contain a dangerous new virus, now being called SARS-CoV-2. It has quarantined entire cities, and the US has put a blanket ban on travellers whove been there. Health officials are scrambling to understand how the virus is transmitted and how to treat patients.

But in one University of North Carolina lab, theres a different race. Researchers are trying to create a copy of the virus. From scratch.

Led by Ralph Baric, an expert in coronaviruseswhich get their name from the crown-shaped spike they use to enter human cellsthe North Carolina team expects to recreate the virus starting only from computer readouts of its genetic sequence posted online by Chinese labs last month.

The remarkable ability to boot up viruses from genetic instructions is made possible by companies that manufacture custom DNA molecules, such as Integrated DNA Technology, Twist Bioscience, and Atum. By ordering the right genes, which cost a few thousand dollars, and then stitching them together to create a copy of the coronavirus genome, its possible to inject the genetic material into cells and jump-start the virus to life.

The ability to make a lethal virus from mail-order DNA was first demonstrated 20 years ago. Its enough of a bioterrorism concern that companies carefully monitor who is ordering which genes. But its also an important way to respond to a sudden outbreak, since synthetic virus recipes give researchers powerful ways to study treatments, vaccines, and how mutations could make it more dangerous.

When a synthetic virus is better than the real thing

Barics North Carolina lab, which specializes in engineering viruses, has previously butted heads with Washington agencies over the work, which has included synthesizing new, never before seen coronaviruses that can infect mice. In 2014, the National Institutes of Health froze funding to several labs, including Barics, over concerns that such research was too risky. The funding was later reinstated.

For the China virus, Baric said in a telephone interview, his team placed an order for matching DNA from a manufacturer last month. Their first step was to go online and look at genetic sequences of the virus. They then compared several available sequences, which differ slightly, and picked a consensus version to have manufactured.

Once Baric gets his DNA, something that could take a month, he plans to inject the genetic instructions into cells. If things go as planned, the cells should begin making actual infectious viral particles.

CDC

By rolling their own germs, scientists can get hold of viruses even if they cant obtain them directly from a country, especially one thats in the grip of an epidemic. Baric says so far samples of the live virus from patients have not been made widely available from China. This is the future in terms of how the medical research community responds to a new threat, says Baric.

The real virus and the synthetic one should be basically identical. But with the synthetic one, we have a DNA copy that we can go back to over and over and over again, to make genetically identical viruses, says Timothy Sheahan, a researcher at UNC who works with Baric. Starting from these copies, scientists can remove genes, add others, and figure out things like what makes the germ spread and how it gains access to human cells. Sheahan wants to try infecting mice with the virus and giving them various drugs to see what stops it.

Artificial copies may also help scientists keep up with the outbreaks unpredictable path. I worry this virus is going to mutate in the course of the epidemic, and this would allow me to study what effects those mutations have, says Stanley Perlman, a microbiologist who works on coronaviruses at the University of Iowa. The synthetic virus is just a substitute for the actual virus, but with the DNA clone you can manipulate it and find the weak points and develop a therapy.

During past outbreaks, scientists would have had to wait months or years to get a look at the germ behind an outbreak. But with SARS-CoV-2 it took only weeks until its genetic sequence was posted online. Immediately, some scientists began analyzing the genetic data, comparing it to viruses from bats, snakes and pangolins; they concluded it could have begun circulating last November.

Biotech companies, governments, and universities also quickly started ordering physical copies of particular genes found in the virus. DNA manufacturers say they have been deluged with orders for virus parts, including those useful for verifying diagnostic tests and others needed to make potential vaccines.

Its been a pretty dramatic uptick, starting with the publication of the genome, says Adam Clore, technical director of synthetic biology at IDT, based in Iowa, and one of the worlds largest sellers of DNA. Its high priority. There are a number of institutions that are devoting nearly all their energy working on detection or vaccines.

Still, most researchers need only one or two genes from the virus to carry forward work on tests and vaccines. Barics lab in North Carolina is the only one in the US known to be trying to re-create the virus completely from ordered DNA parts.

How to keep deadly viruses out of the wrong hands

It was in the early 2000s that scientists first showed that synthetic DNA strands could be used to resurrect viruses just from their genetic code. A team in New York State did it with polio, producing infectious material from DNA they ordered online.

The technology immediately created bio-weapon worries. What if terrorists used the technique to resurrect smallpox? That hasnt happened, but it does mean that scourges like polio, smallpoxand now the Chinese coronaviruscannot now ever be truly wiped out. Researchers at the US Centers for Disease Control and Prevention (CDC) drove that point home in 2005 when they resurrected the influenza virus that killed tens of millions in 1918-1919.

To keep the technology out of the hands of evil-doers, companies that manufacture DNA banded together a few years ago to limit access to dangerous genes. The big US players have all agreed to compare incoming DNA orders to a database of about 60 lethal germs and toxins called select agents so that only authorized labs can ever obtain the DNA needed to resurrect them.

CDC

At our request, Battelle, a scientific R&D company whose software ThreatSEQ can make those comparisons, ran the scenario of someone trying to order a copy of SARS-CoV-2. According to Craig Bartling, a senior research scientist at Battelle, the software flagged both the entire virus, and most of its genes individually, at the highest threat level. Bartling says the alerts went off because the virus is highly similar to the original SARS, a related virus that sparked a global outbreak starting in 2002.

Research into the new virus is seen as risky enough that manufacturers of DNA hurried last week to meet and formulate a policy about who should be able buy complete versions of the new germs genome. In a statement released on February 11, the International Gene Synthesis Consortium, a trade group, struck a cautious position. It said it would treat the new Chinese virus as if it were SARS, a germ added to the select agent list in 2012 and whose possession is tightly monitored by the US government.

That means anyone who wants a complete synthetic copy of SARS-CoV-2 would need to undergo specific and detailed vetting and prove they are already registered by the CDC to work with SARS, as the North Carolina researchers are.

However, companies that manufacture DNA still have discretion over what they sell and to whom, and not all of them think they should make the whole genome of this virus. Claes Gustaffson, founder and chief commercial officer of Atum, a DNA supplier in California, says hes gotten orders from eight companies for parts of the virus genome and has personally approved a request by a US government agency to make 90% of its geneslikely to create an attenuated (i.e., harmless) version of it.

They probably want to figure out how to make a vaccine as quickly as possible, says Gustaffson. But if someone wanted the whole thing, I wouldnt make it. Some things, like polio, you dont want to make, no matter who is asking.

UNC Gillings School of Public Health

Not everyone thinks synthesizing the new coronavirus is particularly dangerous. I dont really see a huge amount of risk, says Nicholas G. Evans, who studies biothreats at the University of Massachusetts, Lowell. Right now, a lot of people are spending a lot of time on how this coronavirus works. I think the risks are outweighed by the benefits.

The outbreak, which appears to have begun in a live animal market in the city of Wuhan, had caused more than 64,000 cases and 1,350 deaths in China by February 14, so its even worse than SARS, which killed 774 people.

Still, the US has not yet declared the new virus to be a select agent. According to Baric, the decision to add a new virus to the most-dangerous list is not made in the expanding outbreak, because it slows down research.

Scaring people

For now, only a very few sophisticated centers can actually re-boot a virus; theres no chance a nut working from a garage could do it. We are at the point where the best of the best can start to synthesize this new virus contemporaneously with the outbreak. But that is just a few labs, says Evans. Fortunately, we are still far from the point when lots of people can synthesize anything.

The advanced state of synthetic virus research, and the ability to genetically engineer germs, inevitably feeds fears, and conspiracy theories. Social media and some blog sites have been full of groundless speculation that the new virus was accidentally released from a Chinese bioweapon lab located outside of Wuhan. Theres no evidence that is the case, and substantial evidence it is not, but the rumor caused a diplomatic breach with China after it was repeated in the US Congress by a senator, Tom Cotton of Arkansas.

Baric says he doesnt see a particular danger to synthesizing the new virus at this stage of the outbreak, especially because the virus is still circulating in the wild. The important thing is to figure out what it does and stop it. Whether you get it from a cell or synthesize it, it ends up the same thing, says Baric.

Read the original here:
Biologists rush to re-create the China coronavirus from its DNA code - MIT Technology Review

Read More...

Page 680«..1020..679680681682..690700..»


2025 © StemCell Therapy is proudly powered by WordPress
Entries (RSS) Comments (RSS) | Violinesth by Patrick