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S2 Genomics and the RIKEN Center for Integrative Medical Sciences Collaborate on Single-Cell Genomics on Solid Tissues – Business Wire

February 22nd, 2020 4:46 pm

LIVERMORE, Calif.--(BUSINESS WIRE)--S2 Genomics, a manufacturer and provider of automated tissue sample preparation systems, and the RIKEN Center for Integrative Medical Sciences (IMS), a leading genomics research institute, today announced that RIKEN IMS has joined the S2 Genomics Early Technology Access Program to evaluate and further develop single cell sequencing applications on the S2 Genomics Singulator tissue preparation system.

Achieving high-quality single cell data from solid tissues relies upon consistent and reproducible cell or nuclei dissociation procedures. To overcome the challenges often seen with manual cell dissociation methods, S2 Genomics has developed the automated Singulator system to process solid tissue samples into suspensions of cells or nuclei for single-cell analysis.

Current methods of cell isolation are a significant bottleneck for researchers and can lead to inconsistencies in their data. The Singulator automates and standardizes the dissociation of solid tissues and can improve the quality of single-cell and single-nuclei data from a variety of solid tissue types, said Dr. Stevan Jovanovich, President and CEO of S2 Genomics. We are excited to work with the RIKEN IMS to evaluate the performance of the system and to develop new applications for the Singulator platform.

Dr. Aki Minoda, Unit Leader of the Epigenome Technology Exploration Unit, commented on the collaboration: We are delighted to collaborate with S2 Genomics and incorporate the Singulator into our workflow for single-cell analyses.

About S2 Genomics, Inc.

S2 Genomics, founded in 2016, is a leading developer of laboratory automation solutions to process solid tissue for life science applications. S2 Genomics technology platforms integrate advanced fluidics, optics, and biochemistry capabilities to produce sample preparation solutions for the next generation sequencing (NGS) and cell biology markets. For more information, visit http://www.s2genomics.com.

S2 Genomics, the S2 Genomics logo, and Singulator are trademarks of S2 Genomics, Inc.

About the RIKEN Center for Integrative Medical Sciences

The RIKEN IMS aims to elucidate the pathogenesis of human diseases and establish new therapeutic methodologies by conducting cutting-edge research on human genome and immune function. To that end, we have established four Divisions: (1) Division of Genomic Medicine, (2) Division of Human Immunology, (3) Division of Disease Systems Biology, and (4) Division of Next Generation Cancer Immunology. These groups work together to promote state-of-the-art research.

For more information, visit https://www.riken.jp/en/research/labs/ims/index.html.

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The WELL Conference Welcomes Three More Speakers to its Lineup – Hospitality Design

February 22nd, 2020 4:46 pm

February 21, 2020

Two globally recognized physicians, a renowned integrative medicine expert, and one of the worlds leading restaurateurs will join the more than 50 leading designers, architects, business leaders, academicians and public health professionals speaking at the WELL Conference, March 29th April 1st, 2020, in Scottsdale, Arizona.

Dr. Jerome M. Adams, the 20th Surgeon General of the United States, is an American anesthesiologist and a vice admiral in the U.S. Public Health Service Commissioned Corps, which represents the whole gamut of public healthfrom engineers to doctors to nurses to pharmacists to environmental health officers. Prior to becoming Surgeon General, he served as the Indiana State Health Commissioner from 20142017.

Dr. Sanjay Gupta, Chief Medical Correspondent, CNN, multiple award-winning journalist, author and neurosurgeon, is frequently referred to as everyones doctor. He recently anchored a six-part CNN docuseries called Chasing Life, exploring unusual traditions and modern practices around the world that constitute a healthy and meaningful life.

Chef David Bouley, one of New Yorks most famous chefs, earned several four-star reviews in The New York Times, multiple James Beard Foundation awards including Best Chef in America, and countless others. He hosts The Chef & the Doctor, a collaborative lecture and dinner event with world-renowned doctors and nutritionists at his New York restaurant, Bouley at Home, demonstrating a practice of well-being that is accessible to home cooks anywhere.

Dr. Mark Hyman is leading a health revolutionone that revolves around using food as medicine to support longevity, energy, mental clarity, happiness and so much more. A practicing family physician and an internationally recognized author, speaker, educator and advocate in the field of functional medicine, Dr. Hyman is a regular participant in The Chef & the Doctor series and will join Chef Bouley onstage for a lively discussion on how what we eat is at the top of the list for creating the vibrant health we deserve.

In different ways, each of these globally renowned leaders is instrumental in shaping this movement towards a healthier future, said Rick Fedrizzi, chairman and CEO of the International WELL Building Institute, the presenter of the conference. They are tremendous ambassadors for health and well-being and their expertise will further the innovative and inspiring experience The WELL Conference is set to be.

The WELL Conference features an expanding roster of thought leaders who are committed to improving the health and wellbeing of people through better buildings and communities and stronger organizations. The education sessions are structured around six distinct tracksLead WELL, Learn WELL, Work WELL, Live WELL, Design WELL and Connect WELL. Attendees will hear perspectives that range from working dads (and their kids) discussing how wellness is advanced when they have more time with each other, to storytellers like Robin Raj, an expert in building citizen brands for organizations interested in living their purpose. Top editors of design publications Contract, Hospitality Design, Healthcare Design and Environments for Aging will report on changes, shifts and the creative thinking they expect to see in the new decade.

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Column: Nutrition for a Healthy Heart | South Lake Tahoe – South Tahoe Now

February 22nd, 2020 4:46 pm

By Amy Smith, FNP, NBC-HWC

Besides being known for bringing candy hearts and lots of snow, February is National Heart Health Month. Heart disease is identified as the leading cause of death in both men and women by the Centers for Disease Control. In addition to screenings that can be done to monitor your hearts health, there are fundamentals of following a preventative heart health lifestyle that can help prevent heart disease and maintain heart health. In addition to not smoking, regular exercise, stress management, it is possible to significantly reduce your risk of heart disease by incorporating heart healthy foods in your everyday diet.

Eating foods known as phytosterols can lower LDL, or, "bad cholesterol. These include Brussels sprouts, peanuts, almonds and wheat germ. Foods that produce nitric oxide as a metabolite by-product can lower blood pressure and keep the lining of the blood vessels healthy; beets and kale are great sources of this beneficial metabolite. Also good for your blood vessels (and gut health) are fermented foods, like yogurt, kimchi and sauerkraut. Magnesium-rich foods like almonds, cashews, pumpkin seeds and sunflower seeds can help maintain a healthy heart rhythm and reduce blood pressure. Anti-inflamatory foods like mushrooms, red grapes, apples, blueberries, salmon and sardines are beneficial as well.

Besides eating a variety of whole foods packed with phytosterols, supplementing with Co-enzyme Q-10 is beneficial to heart and blood vessel function. This also reduces the risk of heart attack and improve cholesterol levels. It is always recommended to talk with your care provider, cardiologist or an integrative medicine practitioner prior to starting any specific supplementation plan.

Healthy fats from an omega-rich diet provides anti-inflammatory benefits and may reduce cholesterol levels. The skinny on fats is to eat sources of monounsaturated fats such as olives, avocados, and extra-virgin olive oil; and polyunsaturated fats from sockeye salmon, sardines and tuna.

Again, it is always recommended to talk with your care provider, cardiologist or an integrative practitioner prior to starting any supplementation. For more information about cardiology services available through Barton Health, visit bartonHealth.org/cardiology. And to schedule an appointment with an integrative medicine practitioner to learn more nutrition and other heart-healthy lifestyle choices, call 530.539.6620. Heres to your heart this February, and throughout the year.

Amy Smith, FNP, NBC-HWC is an integrative medicine practitioner and primary care provider at the Barton Center for Orthopedics & Wellness.

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Why the controversy over chronic Lyme disease is important to everyone – The CT Mirror

February 22nd, 2020 4:46 pm

A response to the CT Viewpoints op-ed Treating chronic Lyme disease: Is it medical fraud? By Lawrence Zemel MD and Paul G. Auwaerter MD, Dec 13, 2019.

The authors reference to so-called chronic Lyme disease ignores the substantial body of evidence that suggests Lyme disease can be chronic and infection can persist following treatment with antibiotics.

The first investigation into the effectiveness of antibiotics for the treatment of Lyme disease was published by Steere in 1983. The study was conducted at a time when prevailing thought held that antibiotics would cure all infectious disease caused by bacteria. Because the findings of the 1983 study were not consistent with that belief, the data were re-categorized to generate the expected result. Critical analysis of the data reveals, however, that nearly 50% of the patients in the study who were treated with antibiotics for 10-20 days continued to experience significant symptoms.

Other studies have produced similar results, yet the Infectious Diseases Society of America (IDSA) ignores independent research and continues to claim that Lyme disease at any stage of infection is cured by a short course of antibiotics.

A 2019 subcommittee report to the Tick Borne Disease Working Group (established by Congress in 2016), stated that the results of more recent studies in animal models by different investigators, lend support to the probability that the effects of persisting organisms are a source, if not the likely source, of ongoing symptoms in patients who have unresolved Lyme disease.

In 2019, The International Lyme and Associated Diseases Society (ILADS) Working Group published a paper in which they systematically reviewed over 250 peer reviewed papers in the international literature and concluded that Lyme disease is the result of ongoing and active infection by any of several forms of B. burgdorferi capable of causing disease in humans.

Zemel and Auwaerter refer to an unsubstantiated notion that 50% of patients with Lyme disease test negative by standard laboratories but there is abundant evidence demonstrating that the two-tiered testing method recommended by the Centers for Disease Control is problematic.

There are many reasons why infected individuals may generate a negative result. Chief among them is the fact that the test relies on the ability of the infected individual to produce antibodies when Lyme bacteria have the ability to suppress the immune system preventing antibody production. Further, there are over 100 species of Borrelia in the U.S. (not all cause disease in humans) and the current two-tiered testing method misses the majority of them. Independent studies have shown these tests to correctly identify only about 56% of those with Lyme disease.

In a 2018 publication in its own journal, the IDSA admitted that reliable direct detection methods for active B. burgdorferi have been lacking in the past but are needed and appear achievable. Despite this, the IDSA guidelines fail to offer treatment options to patients who test negative but have the disease.

The authors suggestion that vulnerable patients need to be protected from Lyme-literate practitioners is both intentionally misleading and unsubstantiated.

Lyme-literate practitioners have a wide variety of medical backgrounds. Many are board-certified medical doctors with expertise in a variety of specialties and have additional training in tick-borne disease, while others are board-certified osteopathic physicians, naturopathic doctors, or nurse practitioners. Many are members of ILADS. Some practitioners have a background in integrative medicine, a holistic approach to health and wellness that combines conventional medicine with complementary and alternative medicine therapies grounded in science. Others are trained in functional medicine whose aim is to determine how and why illness occurs and to restore health by addressing the root cause of illness for each individual.

Some practitioners use a multimodal approach to address factors that might be keeping a patient sick including poor digestive health, food allergies, inflammation, toxicity, and hormone imbalance. They may use prescription and herbal medicines as well as other supplements. Because treating Lyme disease is a time consuming process, it fits poorly into the current model for medical reimbursement. As a result, many practitioners do not accept insurance but will provide documentation that can be submitted to an insurance carrier.

Just as they would with any other medical professional, patients are capable of exercising due diligence when selecting a Lyme practitioner to ensure that the approach to care is consistent with their preferences and beliefs.

The authors reference to the careful scientific rigor associated with the IDSA guidelines revision process does not hold up to scrutiny.

In 2006, Connecticut Attorney General Richard Blumenthal conducted a landmark anti-trust investigation into the IDSAs process for writing its 2006 Lyme disease guidelines. Blumenthals office uncovered undisclosed financial interests held by several of the most powerful IDSA panelists and found that the guidelines panel improperly ignored or minimized alternative medical opinion and evidence regarding Lyme disease, potentially raising serious questions about whether the recommendations reflected all relevant science.

One of the most egregious and dangerous recommendations by the IDSA is the use of a single dose of doxycycline to prevent the development of Lyme disease when given within 72 hours of a tick bite. This advice is based upon a single study with illogical and flawed methodology published nearly two decades ago. It has never been replicated. Data from this study show only that the dose was sufficient to prevent formation of the rash that sometimes develops at the site of a tick bite but not that it halted development of the disease itself. This treatment may promote antibiotic resistance and lead to negative antibody testing making diagnosis even more difficult.

Why this issue is important.

The problem that can arise when evidence is scarce is the misperception that guidelines are based on evidence rather than opinion. The evidence on which both sets of guidelines are based is weak. The authors of the ILADS guidelines acknowledge this directly and the fact that there two sets of conflicting guidelines. The authors of the IDSA guidelines fail to do so.

The 2011 report by the National Academy of Medicine (NAM), Clinical Practice Guidelines We Can Trust, the 2006 IDSA Lyme Disease Guidelines were cited as an example of lack of transparency in guidelines development to illustrate the problems associated with it.

When evidence is weak, clinician discretion is especially important. The ILADS guidelines allow for this and for shared decision-making between patient and practitioner. In contrast, the IDSA guidelines severely restrict the use of clinical judgment.

Why is this important even to those that dont have Lyme disease? Clinical practice guidelines greatly influence the practice of medicine. When lack of transparency, scientific bias, and financial conflicts of interest are allowed to affect them, it places the health of all of us at risk.

Jennifer Shea lives in Longmeadow, Massachusetts.

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U. S. Surgeon General Dr. Jerome M. Adams and CNN Chief Medical Correspondent Dr. Sanjay Gupta Join Chef David Bouley and Dr. Mark Hyman at The WELL…

February 22nd, 2020 4:46 pm

The leading federal spokesperson on matters of public health, CNNs chief medical correspondent, functional medicine advocate and New Yorks favorite chef to speak at the inaugural wellness event March 29 April 1, 2020.

Two globally recognized physicians, a renowned integrative medicine expert, and one of the worlds leading restaurateurs will join the more than 50 leading designers, architects, business leaders, academicians and public health professionals speaking at The WELL Conference, March 29-April 1, 2020, in Scottsdale, Arizona.

Dr. Jerome M. Adams, the 20th Surgeon General of the United States, is an American anesthesiologist and a vice admiral in the U.S. Public Health Service Commissioned Corps, which represents the whole gamut of public healthfrom engineers to doctors to nurses to pharmacists to environmental health officers. Prior to becoming Surgeon General, he served as the Indiana State Health Commissioner from 20142017.

Dr. Sanjay Gupta, Chief Medical Correspondent, CNN, multiple award-winning journalist, author and neurosurgeon, is frequently referred to as "everyones doctor." He recently anchored a six-part CNN docuseries called "Chasing Life," exploring unusual traditions and modern practices around the world that constitute a healthy and meaningful life.

Chef David Bouley, one of New Yorks most famous chefs, earned several four-star reviews in The New York Times, multiple James Beard Foundation awards including Best Chef in America, and countless others. He hosts The Chef & the Doctor, a collaborative lecture and dinner event with world-renowned doctors and nutritionists at his New York restaurant, Bouley at Home, demonstrating a practice of well-being that is accessible to home cooks anywhere.

Dr. Mark Hyman is leading a health revolutionone that revolves around using food as medicine to support longevity, energy, mental clarity, happiness and so much more. A practicing family physician and an internationally recognized author, speaker, educator and advocate in the field of functional medicine, Dr. Hyman is a regular participant in The Chef & the Doctor series and will join Chef Bouley onstage for a lively discussion on how what we eat is at the top of the list for creating the vibrant health we deserve.

"In different ways, each of these globally renowned leaders is instrumental in shaping this movement towards a healthier future," said Rick Fedrizzi, chairman and CEO of the International WELL Building Institute, the presenter of the conference. "They are tremendous ambassadors for health and well-being and their expertise will further the innovative and inspiring experience The WELL Conference is set to be."

The WELL Conference features an expanding roster of thought leaders who are committed to improving the health and well-being of people through better buildings and communities and stronger organizations. The education sessions are structured around six distinct tracksLead WELL, Learn WELL, Work WELL, Live WELL, Design WELL and Connect WELL. Attendees will hear perspectives that range from working dads (and their kids) discussing how wellness is advanced when they have more time with each other, to storytellers like Robin Raj, an expert in building "citizen brands" for organizations interested in living their purpose. Top editors of design publications Contract, Hospitality Design, Healthcare Design and Environments for Aging will report on changes, shifts and the creative thinking they expect to see in the new decade.

Visit thewellconference.com to register and review the schedule of events and speakers and follow along on social media: Twitter, Facebook, LinkedIn and Instagram.

About The WELL Conference

A first-of-its-kind wellness gathering, The WELL Conference is a curation of information and inspiration from thought leaders, experts and innovators representing multiple sectors of the wellness movement. Presented through thought-provoking and immersive content focused on how our buildings and everything in them can enhance, not compromise our health, this gathering will provide a deeper understanding how to live well at every turn. The event will take place March 29-April 1, 2020, at the Fairmont Princess in Scottsdale, Arizona. The WELL Conference is presented by the International WELL Building Institute in collaboration with the American Society of Interior Designers and powered by Emerald.

International WELL Building Institute, IWBI, the WELL Building Standard, WELL v2, WELL Certified, WELL AP, WELL, WELL Portfolio, The WELL Conference, the WELL Community Standard and others, and their related logos are trademarks or certification marks of International WELL Building Institute pbc in the United States and other countries.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200220005961/en/

Contacts

Press Wanita Niehaus Media@thewellconference.com

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U. S. Surgeon General Dr. Jerome M. Adams and CNN Chief Medical Correspondent Dr. Sanjay Gupta Join Chef David Bouley and Dr. Mark Hyman at The WELL...

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Alternatives to Drinking: How to Relax Without Alcohol – LIVESTRONG.COM

February 22nd, 2020 4:46 pm

When most people clean up their diets to lose weight or boost their overall health, one of the first things they're told to cut out is alcohol. After all, no amount of alcohol is particularly "good" for you, per an August 2018 analysis in The Lancet and it's certainly not low in calories, no matter which type you're sipping.

Meditation is one way to relax without alcohol.

Credit: Westend61/Westend61/GettyImages

But for many, a glass of wine or a cold beer at the end of a long workday is a go-to way to de-stress and unwind. And that's nothing to sneeze at, because lowering your stress levels can be key for weight loss, too.

While a casual drink may seem harmless, there's often a biological component at play that keeps alcohol at the top of the list of favorite de-stressors, Roger Adams, PhD, personal trainer, doctor of nutrition and owner of eatrightfitness, tells LIVESTRONG.com.

"At its basic level, alcohol of any kind is a depressant, meaning it slows down the activity and processes of the brain and central nervous system," Adams says. "If used only occasionally for stress relief, alcohol is likely to be quite effective in the short-term. However, we tend to need to consume more over time to get the same de-stressed feeling, so consumption is likely to increase."

This increased alcohol consumption over time can cause myriad health problems, including mood and behavior disruptions, high blood pressure, stroke, liver disease and even cancer, according to the National Institute on Alcohol Abuse and Alcoholism.

Many of us may find it difficult to relax without alcohol, but there are compelling health benefits to limiting your intake.

Credit: BrianAJackson/iStock/GettyImages

On the other hand, stress is also a major health issue. One March 2018 study in the journal Psychological Science found that even stress that is seen as small and insignificant can lead to health problems including heart disease, anxiety and depression, chronic pain and more.

Another November 2018 study in Neurology discovered that a high-stress lifestyle could lead to memory loss and brain shrinkage before the age of 50.

And, like alcohol, stress doesn't help your waistline either. Those who suffer from long-term stress are more likely to be obese, according to a study published February 2017 in the journal Obesity. The main culprit is cortisol, a stress-induced hormone that can encourage your body to hold onto fat.

In short: If both stress and drinking are bad for you, the healthiest lifestyle is one that includes less of both.

Luckily, there are plenty of stress-relieving solutions that can help you whittle your waistline and boost your health. Here, experts share their science-backed alternatives to drinking that can still help relieve stress.

Exposure to nature has a lot o benefits, including a better mental state of wellbeing as you leave all the noise of life behind, Adams says.

This was shown in an April 2019 study published in Frontiers in Psychology, which examined two biomarkers of stress when exposed to nature: salivary cortisol, a measure of the amount of stress hormone in the saliva, and alpha-amylase, digestive enzymes. They found that both stress biomarkers dropped in people when they were exposed to nature.

So instead of happy hour after work, suggest taking a walk or throwing a frisbee in the park with your pals, or simply take a walk through the trees after dinner instead of parking yourself on the sofa with a cold one.

Did you know that keeping a food diary is one of the most effective ways to manage your weight? Download the MyPlate app to easily track calories, stay focused and achieve your goals!

Meditation can be a powerful stress-reliever, according to a systematic review and meta-analysis published March 2014 in JAMA Internal Medicine. After reviewing 47 trials, the researchers concluded that mindfulness meditation can improve levels of anxiety, depression and pain as well.

Another study, published July 2019 in Scientific Reports, found that it takes as little as 40 days of meditating to change your brain waves enough to improve stress.

"Progressive relaxation meditation involves a guided experience where you relax each part of your body, as well as calm the inner chatter that often feeds stress and worry and keeps us too stimulated for sleep," Roseann Capanna-Hodge, PsyD, psychologist and certified integrative medicine mental health provider, tells LIVESTRONG.com.

One of the best parts about meditating is that it's easy to do anywhere all you need is a safe and quiet place to sit, reflect and calm your mind. If you're looking for a little guidance, consider downloading one of the many meditation apps out there, such as InsightTimer or Calm.

Practice yoga as a healthy alternative to alcohol for stress relief.

Credit: fizkes/iStock/GettyImages

Like meditation, yoga is a good alternative to drinking that can provide boundless benefits for the body and mind, particularly when it comes to reducing levels of stress, anxiety and depression, per a February 2018 study in the International Journal of Preventive Medicine.

"By performing yoga moves and breathing properly, you can promote your mental health through the relief of stress," Jamie Bacharach, medical acupuncturist and yoga practitioner, tells LIVESTRONG.com. "Due to its use of meditation-like posing and deliberate breathing, yoga has the ability to increase your own body awareness, relax the mind and give you a sharper focus, all of which contribute to optimized mental health."

Being mindful of one's surroundings and using visualization to reduce stress has become an increasingly popular technique. Though it sounds quite similar, visualization is different than mindfulness or meditation.

"Visualization involves actually visualizing what you want and honing in on one's authentic purpose to create goals around it," explains Dr. Capanna-Hodge. "It's a powerful way to not only get clarity on your goals but to help manifest them."

To incorporate visualization into your day-to-day, Dr. Capanna-Hodge suggests taking a few minutes to sit in a quiet place and visualize what you want to accomplish and pair it with action around those goals that move them to positive outcomes.

"Whether you have a goal to better manage stress or address a specific issue, intent-oriented visualization is a great way to create positive momentum by getting to the core of the issue and its resolution," she says.

"The lasting effects throughout the day of a short workout can provide the calming effect that you may be looking for in that after-work cocktail."

It might sound simple and it is but getting your heart rate up is one of the best ways to reduce the effects of stress.

When you exercise, your body amps up its production of the "feel-good" hormone known as endorphins, while stress does the complete opposite, explains Joseph De Santo, MD, board-certified physician and addiction specialist for the BioCorRx Recovery Program.

Indeed, in responses gathered for the American Psychological Association's Stress in America 2019 survey, a whopping 53 percent of adults reported that they feel good about themselves after exercising, and 30 percent reported feeling less stressed.

"No matter what you are doing, if you are moving, oxygen is getting to the brain more efficiently and endorphins are being released," Dr. De Santo says. "The lasting effects throughout the day of a short workout can provide the calming effect that you may be looking for in that after-work cocktail."

Using essential oils is one way to relax without alcohol.

Credit: JGI/Tom Grill/Tetra images/GettyImages

Essential oils not only smell nice, but they can have a beneficial effect on both your brain and body.

Lavender oil in particular, has been shown to help alleviate symptoms of anxiety, according to one July 2017 study published in The Mental Health Clinician.

"When essential oil molecules enter the nose or mouth, they pass to the lungs and eventually the brain and other parts of the body, stimulating the olfactory system, which is the part of the brain connected to smell," Dr Capanna-Hodge explains. "As the molecules reach the brain, they affect several regions, including the limbic system, which is linked to the emotions, our memory and attentional systems, as well as our hormone and immune systems, and can lower cortisol and stress levels."

She recommends using an infuser to disperse essential oils around your home or workplace to keep your stress levels low and your body relaxed.

This nutrient has numerous health benefits, including enhancing bone health and reducing one's risk for diabetes, heart disease and anxiety. It also has impressive stress-relieving perks, as shown in a May 2017 study published in Nutrients, which found magnesium supplementation to be beneficial in relieving anxiety as well as stress.

"By supplementing with magnesium, you not only calm the nervous system, you help your body combat stress and give it what it needs to work at an optimal level," says Dr. Capanna-Hodge.

You can take a magnesium supplement, but you can also score the nutrient in certain foods, particularly spinach, almonds, avocado, tofu and dark chocolate.

Keep in mind the recommended daily intakes for magnesium, according to the National Institutes of Health:

Most Americans (1 in 3) are not getting their fair share of shut-eye and it's having a negative affect on their health and overall wellbeing, according to the Centers for Disease Control and Prevention.

What's more: Oftentimes stress is the cause of inability to sleep well. A National Sleep Foundation poll found that 43 percent of young and middle-aged adults report difficulty sleeping at night as a result of stress at least once a month.

"Getting to bed and getting enough sleep for four to five REM cycles (typically six hours minimum) can provide your brain the healing time that allows it the chance to re-organize and refresh, so you don't carry stress over from the previous day," Dr. De Santo says.

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Should we give up flying for the sake of the climate? – BBC News

February 22nd, 2020 4:46 pm

Investing in a good carbon offset project will probably help to do some good somewhere in the world, adds Hewitt, but it wont make the emissions from your flight go away. Offsetting just can't be a long-term solution, she says. Many people object to offsetting as it implies wealthier individuals can keep contributing to climate change without altering their behaviour.

While giving up flying can feel like a choice to curb your own freedom, travel and the opportunity to experience different cultures, its increasing role in climate change is putting many of our most cherished environments at risk.

But if we do choose to shift our mindsets, we could find the pleasures of slow travel and the discovery of what we have been missing on our own doorsteps could be worth the sacrifice.

* Jocelyn Timperley is a freelance climate change reporter. You can find her on Twitter @jloistf.

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Health Coaching Market 2020 To See Booming Ahead including top key vendors like -Aetna, American Association for Health Education, American Council of…

February 22nd, 2020 4:45 pm

The Global Tuberculosis Diagnostics Market has observed continuous evolution in the past few years and is projected to grow even more during the predicted period (2020-2026). This research report represents a 360-degree overview of the competitive landscape of the Core Elements of Market. Moreover, it offers huge data relating to recent trends, technological progressions, tools, and practises. The research report analyzes every aspect in a detailed and concise manner for better insights into the business.

The latest on report the global Tuberculosis Diagnostics market provides thorough understanding of important aspects of industry. It prepares players as well as investors to take important decisions and plan for growth beforehand by forecast 2026.

Click to Download and Get the Free Sample PDF File of the report: https://www.globalmarketers.biz/report/life-sciences-/global-tuberculosis-diagnostics-market-research-report-2020-2026-of-major-types,-applications-and-competitive-vendors-in-top-regions-and-countries/143942 #request_sample

Major industry players:

DanaherBioMerieuxBDRocheQiagenThermo Fisher ScientificOxford ImmunotecHologicAbbottHain LifescienceEpistemAkonni BiosystemsCreative Diagnostics

The competitive outlook segment of the report presents a clear diffusion into the market share analysis of key industry players. It includes numerous important aspects counting leading competitors which include their business profiling, Tuberculosis Diagnostics market share, gross margin, sales, revenue, growth rate as well as it provides value chain analysis, capacity utilization analysis, SWOT analysis to dig deeper. The companies referred to in the market research report include

The report comprehensively investigates the Global Tuberculosis Diagnostics market status, supply, sales, and production. The global market divisions of production and exchanges are evaluated along with the review of the production, capacity, sales, and revenue. Various aspects such as Tuberculosis Diagnostics import/export, price, gross margin, consumption, and value are also examined.

Market Can Be Split Into Product Types As

Culture-basedSputum Smear MicroscopyRapid MolecularOthers

Tuberculosis Diagnostics Market Can Be Split Into Applications As

HospitalDiagnostic LaboratoriesOthers

The Geographical Analysis Covers the Following Regions

North America (Canada & U.S.) & Latin America (Mexico, Brazil, Peru, Chile, and others)

Western Europe (Germany, U.K., France, Spain, Italy, Nordic countries, Belgium, Netherlands, and Luxembourg) & Eastern Europe (Poland and Russia)

Asia-Pacific (China, India, Japan, ASEAN, Australia, and New Zealand)

Middle-East & Africa (GCC, Southern Africa, and North Africa)

Inquiry Here For Detail Report @ https://www.globalmarketers.biz/report/life-sciences-/global-tuberculosis-diagnostics-market-research-report-2020-2026-of-major-types,-applications-and-competitive-vendors-in-top-regions-and-countries/143942 #inquiry_before_buying

Key Topic Covered:

Growth Opportunities

Market Growth Drivers

Leading Market Players

Market Size and Growth Rate

Market Trend and Technological

Company Market Share

Table of Contents for market shares by application, research objectives, market sections by type and forecast years considered.

This Report Provides Comprehensive Analysis Of:

Request for Detailed Report TOC (Table of Contents) @ https://www.globalmarketers.biz/report/life-sciences-/global-tuberculosis-diagnostics-market-research-report-2020-2026-of-major-types,-applications-and-competitive-vendors-in-top-regions-and-countries/143942 #table_of_contents

Table of Contents Describing Detail Research Report:

1. Tuberculosis Diagnostics Market Report Overview

2 Global Tuberculosis Diagnostics Growth Trends

3. Tuberculosis Diagnostics Market Share by Manufacturers by

4. Tuberculosis Diagnostics Market Size by Type

5. Tuberculosis Diagnostics Market Size by Application

6. Tuberculosis Diagnostics Production by Regions

7 Perfusion Imaging by Regions

8. Tuberculosis Diagnostics Company Profiles

9. Tuberculosis Diagnostics Market Forecast 2020-2026.

10 Value Chain and Sales Channels Analysis

11 Opportunities & Challenges, Threat and Affecting Factors

12 Key Findings

13 Appendix

Complete report on Tuberculosis Diagnostics market report spread across 100+ pages, list of tables & figures, profiling 10+ companies.

The report answers several questions about the Tuberculosis Diagnostics Market includes:

1. What will be the Tuberculosis Diagnostics industry size in 2026?

2. What will be the market growth rate in 2026?

3. Which key factors drive the market?

4. Who are the key market players for market?

5. Which strategies are used by top players in the market?

6. What are the key market trends in Tuberculosis Diagnostics market?

7. Which trends and challenges will influence the growth of market?

8. Which barriers do the markets face?

9. What are the market opportunities for vendors and what are the threats faced by them?

10. What are the most important outcomes of the five forces analysis of the market?

Request for Detailed Report TOC (Table of Contents) @ https://www.globalmarketers.biz/report/life-sciences-/global-tuberculosis-diagnostics-market-research-report-2020-2026-of-major-types,-applications-and-competitive-vendors-in-top-regions-and-countries/143942 #table_of_contents

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POTUS India visit: Trump expected to talk Kashmir,says US Officials – The Kashmir Monitor

February 22nd, 2020 4:45 pm

New Delhi, Feb 22: In a bid to address the concerns of the local populace after the revoking of Jammu and Kashmirs special status last year, Union Minister Jitendra Singh on Saturday assured the people of the Union Territory that the domicile law is coming very soon which would be followed by the Land Act.He also announced that more than the promised jobs will be provided to the youth after the notification of the rules is worked out.The domicile act is coming very soon, which will be immediately followed by the Land Act, the minister of state in the Prime Ministers Office said.Many parties have been demanding enactment of a domicile law for Jammu and Kashmir to protect the interests of landowners and the unemployed youth after the erstwhile state lost its special status following nullification of Article 370 by the Centre.Singh was addressing a function after signing of a major scientific collaboration agreement between CSIR-Indian Institute of Integrative Medicine, Jammu, and IndusScan, a Canadian pharmaceutical company, here.Describing the signing of the MoU as a historic moment, the minister said Jammu and Kashmirs journey to become a part of Indias five trillion global economy has started from the four walls of IIIM.Prime Minister Narendra Modi is saying again and again that we would have the same kind of focus on Jammu and Kashmir and Ladakh as we did for North-East which saw major transformation over the last five years. Those who have doubts about it would see all this happening in a short while of time, he said.The minister said this is possible because the earlier embargoes have been removed and the Union Territory is directly reporting to the Centre.Many of the politicians have become unemployedheard yesterday one of them raising the issue of jobs to the local youth. I want to tell that more than the promised jobs will be advertised but as per the rules and in an impartial manner. We are waiting for a notification of the rules to come out, he said.Alleging brazen disregard for the concerns of the educated unemployed and underemployed youth by the incumbent government, National Panthers Party Chairman and former minister Harsh Dev Singh had said not a single post, out of the promised 50,000 jobs, had been advertised for filling up in the new UT after the abrogation of Article 370 provisions.Everything will be done. It will not be like when your government was in power and ruined the future of the youths by backdoor appointments and corrupt practices. The youth who were provided jobs have turned 35 years but are still waiting for their regularisation, the Union minister said.He said the jobs will be provided under rules which will be in the best interest of the youth and those who have been deprived of it.Asserting that India is going through one of the best phases under the leadership of Modi, he said a lot of development had taken place over the last five years and the country is looking forward to become a part of the global economy.On the one hand India is eyeing five trillion economy, dont you want that Jammu and Kashmir should also be part of that. It is possible only when our youth reaches such a stage to live up to the parameters which are followed globally and therefore, even if some of us have any doubts, confusion and skepticism or still unconvinced, ask themselves that dont you want your children to be part of five trillion economy.If you understand it, I think all the murmuring and whispering which is generated from thoughtless minds will vanish away, Singh said.The minister said Jammu and Kashmir is also under the process of a new industrial policy and a new scientific policy.The greatest disadvantage that has happened from Jammu and kashmir remaining in isolation because of Article 370 is that we become lazy and lethargic. We learnt to live on easy freebies, he said.

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POTUS India visit: Trump expected to talk Kashmir,says US Officials - The Kashmir Monitor

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Nine dead, five injured in Kathua mishap – The Kashmir Monitor

February 22nd, 2020 4:45 pm

New Delhi, Feb 22: In a bid to address the concerns of the local populace after the revoking of Jammu and Kashmirs special status last year, Union Minister Jitendra Singh on Saturday assured the people of the Union Territory that the domicile law is coming very soon which would be followed by the Land Act.He also announced that more than the promised jobs will be provided to the youth after the notification of the rules is worked out.The domicile act is coming very soon, which will be immediately followed by the Land Act, the minister of state in the Prime Ministers Office said.Many parties have been demanding enactment of a domicile law for Jammu and Kashmir to protect the interests of landowners and the unemployed youth after the erstwhile state lost its special status following nullification of Article 370 by the Centre.Singh was addressing a function after signing of a major scientific collaboration agreement between CSIR-Indian Institute of Integrative Medicine, Jammu, and IndusScan, a Canadian pharmaceutical company, here.Describing the signing of the MoU as a historic moment, the minister said Jammu and Kashmirs journey to become a part of Indias five trillion global economy has started from the four walls of IIIM.Prime Minister Narendra Modi is saying again and again that we would have the same kind of focus on Jammu and Kashmir and Ladakh as we did for North-East which saw major transformation over the last five years. Those who have doubts about it would see all this happening in a short while of time, he said.The minister said this is possible because the earlier embargoes have been removed and the Union Territory is directly reporting to the Centre.Many of the politicians have become unemployedheard yesterday one of them raising the issue of jobs to the local youth. I want to tell that more than the promised jobs will be advertised but as per the rules and in an impartial manner. We are waiting for a notification of the rules to come out, he said.Alleging brazen disregard for the concerns of the educated unemployed and underemployed youth by the incumbent government, National Panthers Party Chairman and former minister Harsh Dev Singh had said not a single post, out of the promised 50,000 jobs, had been advertised for filling up in the new UT after the abrogation of Article 370 provisions.Everything will be done. It will not be like when your government was in power and ruined the future of the youths by backdoor appointments and corrupt practices. The youth who were provided jobs have turned 35 years but are still waiting for their regularisation, the Union minister said.He said the jobs will be provided under rules which will be in the best interest of the youth and those who have been deprived of it.Asserting that India is going through one of the best phases under the leadership of Modi, he said a lot of development had taken place over the last five years and the country is looking forward to become a part of the global economy.On the one hand India is eyeing five trillion economy, dont you want that Jammu and Kashmir should also be part of that. It is possible only when our youth reaches such a stage to live up to the parameters which are followed globally and therefore, even if some of us have any doubts, confusion and skepticism or still unconvinced, ask themselves that dont you want your children to be part of five trillion economy.If you understand it, I think all the murmuring and whispering which is generated from thoughtless minds will vanish away, Singh said.The minister said Jammu and Kashmir is also under the process of a new industrial policy and a new scientific policy.The greatest disadvantage that has happened from Jammu and kashmir remaining in isolation because of Article 370 is that we become lazy and lethargic. We learnt to live on easy freebies, he said.

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Nine dead, five injured in Kathua mishap - The Kashmir Monitor

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IIT Gandhinagar to organise International Conference on Urban Transformations, Youth Aspirations and Education in India – India Education Diary

February 22nd, 2020 4:45 pm

Gandhinagar: Indian Institute of Technology Gandhinagar (IITGN) and the National Institute of Educational Planning and Administration (NIEPA), New Delhi, are jointly organising an International Conference on Urban Transformations, Youth Aspirations and Education in India on February 20-21, 2020. The two-day conference intends to evolve an inter-disciplinary engagement on the nature of urban transformations and the youth in India while understanding policy dynamics in these areas. It will also attempt to understand the challenges to educational access and skills provision for the youth and the constraints of rural-urban migration, social caste background, and peri-urban locations.

Dr Bhushan Patwardhan, Vice Chairman, University Grants Commission (UGC), New Delhi, will be the Chief Guest at the inaugural program. Dr Patwardhan is a biomedical scientist and a Fellow of National Academy Sciences (India) and National Academy of Medical Sciences (India). He has worked on several policy making bodies including Task Forces of National Knowledge Commission, Planning Commission and has been a consultant to the World Health Organization, Geneva. He is Editor-in-Chief of the Journal of Ayurveda and Integrative Medicine published by Elsevier and is on the Editorial Boards of many reputed Journals. He will speak at the Inaugural Panel on Education along with Prof Sudhir Jain, Director, IIT Gandhinagar; and Prof Pankaj Chandra, Vice Chancellor, Ahmedabad University.

There will also be two keynote lectures on each day of the event. Prof Craig Jeffrey, Professor of Geography at the University of Melbourne, Australia and Director, Australia India Institute, will deliver the first Keynote Lecture titled Fresh Contact: Empowering Youth Innovators in South Asia on February 20. Prof Jeffrey is the author of the book Time pass: Youth, Class and the Politics of Waiting, which is a study of youth which is a study of youth aspirations in small-town North India. The second Keynote Lecture will be delivered by Prof John Harriss, Professor Emeritus of International Studies, Simon Fraser University, Canada, titled Aspiration, Opportunity, Mobility: the prospects for development among Indias youth, on February 21.

The first day of the conference will also have a short film screening titled Lifelines: documenting social change in the Indian Himalayas by Jane Dyson, Professor Anthropology at the University of Melbourne.

Many scholars and experts from India and abroad are invited as speakers during various sessions that will cover a wide range of subjects such as Educational Conundrums of Indian Youth; Youth and Political Mobilisation; Studying the Youth: Methods and Approaches; Peri-urban/Small Town Youth Aspirations; and Urban Landscapes: Marginality and Circulation.

Postgraduate and doctoral students, senior undergraduate students, faculty and researchers in Humanities and Social Sciences from all over the country are going to participate in this international conference. More details about the conference and speakers can be found on the conference website: http://events.iitgn.ac.in/2020/UTYAEI/index.php

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IIT Gandhinagar to organise International Conference on Urban Transformations, Youth Aspirations and Education in India - India Education Diary

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Second batch of Union ministers to visit JK in April – The Kashmir Monitor

February 22nd, 2020 4:45 pm

New Delhi, Feb 20: The second batch of about 40 Union ministers is likely to visit Jammu and Kashmir in April to get first-hand information about various development schemes initiated thereby both the central government and the Union Territory administration, officials said on Thursday.

The PrimeMinisters Office (PMO) will decide the composition of the ministerialdelegation that will undertake the follow up of the first visit of 37 Unionministers, who had toured Jammu and Kashmir last month.

A secondbatch of about 40 Union ministers may undertake a visit to Jammu and Kashmir.Dates and composition of the team have not been fixed yet but it will be donesoon after the Budget session of Parliament, a government official said.

After the recess,the second part of the budget session will begin on March 2 and it will end onApril 3.

The PMO willfinalise the list of the ministers and each minister will be assigned aparticular district and focus will be on the Kashmir Valley, the official said.

Some of theministers of the first batch may also be part of the second batch, he said.

The ministerswill assess the development initiatives undertaken by the central government aswell as the UT administration on the ground and they will not talk aboutpolitical issues, the official said.

By interactingwith the locals, they will try to get first-hand information about the roads,healthcare facilities, power situation, functioning of academic institutionsetc. in the UT, he added.

As many as 37central ministers had visited Jammu and Kashmir last month following a directiveof Prime Minister Narendra Modi, who wanted an honest assessment of the variouswelfare schemes being implemented there.

Among those whohad visited Jammu and Kashmir were Law Minister Ravi Shankar Prasad, SportsMinister Kiren Rijiju, ministers of state for home G Kishan Reddy and NityanandRai.

The Unionministers have already submitted their feedback to the PMO on theimplementation of various development schemes there.

There were twosets of feedback one on the initiatives taken by the UT administration andthe other on the Centres initiatives another official said.

Most of thecentral ministers stayed overnight at their respective places of visit such asBaramulla, Ganderbal, Doda, besides others.

In August lastyear, the Centre abrogated Article 370 provisions of the Constitution, whichgave a special status to the erstwhile state of Jammu and Kashmir, andbifurcated it into UTs Jammu and Kashmir, and Ladakh.

Since then, theCentre has been closely monitoring the on the ground implementation of variousdevelopment programmes there.

Jammu and Kashmiris currently under the Presidents rule.

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Second batch of Union ministers to visit JK in April - The Kashmir Monitor

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It’s Time the AYUSH Medicinal Systems Developed a New Vocabulary – The Wire

February 22nd, 2020 4:45 pm

The recent advisory from the Ministry of AYUSH on treatments available in traditional medicine against the new COVID-19 epidemic rightfully created an uproar. There is no scientific evidence that the prescribed medicines work. Indeed, at the time all classical medical texts were collated, people didnt have an understanding of a virus. What there was instead, and which still guides treatment in these medical systems, is a holistic plant-based approach to managing symptoms; in the case of the advisory, for respiratory conditions. So why did the ministry publish unscientific statements? And what drives the almost instantaneously binary reaction to claims from traditional knowledge practices?

To answer this, its necessary to understand the history of medical education in India. Like all education before colonial times, Ayurveda too was also taught in the guru-shishya parampara, a system in which the student was immersed in the gurus household and practice, with a strong hands-on training component. Modern medicine came with the colonialists. In 1822, instructions in western and Indian medicine (Unani and Ayurveda) commenced in Calcutta, but by 1835 Thomas Macaulay effected a policy to withdraw support for instructions in native languages as well as for native medical practices.

Hereon, the colonial and later Indian governments undertook investments to increase the number of medical colleges offering education in western medicine in the country. The Medical Council of India Act of 1956 institutionalised this process, and has since decided on the MBBS degree curriculum. Meanwhile, it was predominantly princely endowments that helped the Indian state setup institutions to train students in traditional medicine. The Maharaja of Travancore had established one of the oldest in 1889 in Thiruvananthapuram, and which has since become the Government Ayurveda Medical College. However, it was not until 1970, with the passing of the Indian Medicine Central Council Act, that Ayurveda and Unani training became institutionalised.

This regulatory divide at the top ensured that from the very start of professional training, modern and traditional medical practitioners are kept separated. To this day, an MBBS degree includes no courses in traditional medicine and vice versa, although Ayurveda doctors do study modern anatomy and physiology. While modern biological sciences like biochemistry, genetics, microbiology, etc. are part of an MBBS education, they find no mention in a BAMS degree. Each group is siloed off, and further divided by socio-cultural imprints, with a rather ungenerous alternate label attached to traditional medicinal practices. Even on campuses that have a cluster of excellent science research departments, there is no exchange of staff and students between the Ayurveda college and the rest of the sciences. Structural bifurcation doesnt stop at medical education: it also extends to biomedical research.

Also read: How the Calcutta Medical College Led to the Rise of Biomedicine in India

In 2014, the government decided to hive off what was until then the Department AYUSH as a separate ministry to boost teaching, research and engagement with Indias traditional medical systems. This would have been an excellent policy decision had it not resulted in programmes where, once again, researchers and practitioners of modern biology are not actively involved in grant-giving committees or policy discussions. Its almost certain that the AYUSH ministry did not run their new advisory by any virologist in the country either, not because there arent any but because they dont feature on their rolodex of experts.

Thus we have a treasure trove of information on medical practices that have not been examined in a system that we know as the scientific method. The practice of testing hypotheses and rigorously demonstrating cause and effect has not permeated AYUSH. A favourite refrain of traditional medical practitioners is that it is difficult to perform clinical trials in the strict reductionist approach of modern science because, by philosophy, traditional medicine is personalised.

This is only the start of differences in vocabulary that then precipitate a binary situation: either believe in traditional medicine or dont. But what if we removed belief from this conversation? We must embrace openness and look for commonalities, the most important being that both streams are about saving lives and improving the quality of life. Modern medicine needs to acknowledge that it doesnt have a treatment for all diseases just as much as traditional medicine needs to acknowledge the same thing. We need more conversations between practitioners and researchers of both medical streams to start unpacking the potential of integrative treatments: the success of traditional medicine for chronic illnesses plus the superior surgical skills and life-saving technologies of modern medicine.

Further, we need to reimagine clinical trials to include personalised approaches to healing with metrics that include formulations as well as single chemical entities. We need the participation of the research fraternity, from biologists to statisticians and engineers, to describe new metrics to measure the efficacy of traditional medicine. Unfortunately, the only way an Ayurveda vaidya interacts with these professions today is in the form of a patient.

A lack of cohesive policymaking that aims to rigorously evaluate and integrate knowledge streams for human wellbeing is preventing us from reaping the full potential of the two. Remarkably, the Charaka Samhita, a basic textbook in Ayurveda, describes a good physician as one who is dynamic and constantly evolving. Its time to take this classical advice seriously.

Megha is an assistant professor at the Centre for Ayurveda Biology and Holistic Nutrition, The University for Trans-Disciplinary Health Sciences and Technology, Bengaluru. The views expressed here are personal.

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Boyd named chief scientific officer at Cancer Institute – News – The Island Now

February 22nd, 2020 4:44 pm

Jeff Boyd will be serving as vice president and chief scientific officer and director of the Center for Genomic Medicine at Northwell Health Systems Cancer Institute in Lake Success. He will also hold an appointment as professor and member of the Cold Spring Harbor Laboratory Cancer Center.

Boyd, who began in his position on Feb. 10, was working at the Miami Cancer Institute when he received the offer from Northwell.

It sounded like a great opportunity, Boyd said. Part of it involved being director of the Center for Genomic Medicine, being chief of science for the Cancer Institute, working at the Cold Spring Harbor lab, strengthening that relationship, providing them access to oncologists here, as well as tissue specimens and such that they need in a cancer research lab.

Part of the doctors job will involve the creation of a clinical laboratory and molecular diagnostic lab certified by the Department of Health, where researchers can obtain tumor specimens from cancer patients, isolate DNA and use a state-of-the-art technology known as next-generation DNA sequencing to define genetic architecture of a specific tumor in an individual.

Every breast cancer is different, liver cancer is different, colon cancer is different by the person, Boyd said.

The institute is also looking into the mutations that cause normal cells to turn cancerous, matching certain mutations to specific drugs in a way that Boyd likens to a lock and key.

Were at a point now in our understanding of cancer genetics in drugs being developed that we can match specific drugs precision cancer medicine match a drug to a mutation in that patients tumor, and it stops what its doing to make a normal cell a cancer cell, Boyd said. Thats whats looking to replace chemotherapy. Most of the therapy is nontoxic, it would describe mutations in tumor and any drugs available for that mutation, and thats the future of cancer treatment.

Another operational unit has to do with banking cancer specimens and fluids like blood and urine from cancer patients, where a state-of-the-art specimen vial depository that will take samples ranging from tumor tissue, blood, and urine, all connected to electronic med record.

The days of taking small bits of tumor or vials of blood and putting them in freezer are gone, Dr. Boyd said.

These specimens will be available to any researchers in the Northwell system, as well as those in the Cold Spring Harbor laboratory.

Our colleagues at Cold Spring Harbor are important to the success of our work, Dr. Boyd said.

Dr. Richard Barakat, physician-in-chief and director of the Northwell Health Cancer Institute and senior vice president of cancer services at Northwell Health, had worked with Dr. Boyd at Memorial Sloan Kettering Cancer Center.

Genomics has become an important piece to helping us understand the genetic roots of the various forms of cancer, which is why it has become an important area of investment for Northwell Health, Barakat said. We are extremely fortunate to have such an esteemed cancer researcher and internationally-known genomics expert such as Boyd to join the Cancer Institutes leadership team.

Boyd has over 30 years of cancer research experience, most recently serving on the executive leadership team of the Miami Cancer Institute at Baptist Health South Florida as associate deputy director of translational research and genomic medicine.

He also served as a professor and chair of the department of human and molecular genetics, professor of obstetrics and gynecology, and associate dean for basic research and graduate programs at the Herbert Wertheim College of Medicine at Florida International University.

Prior to joining the Miami Cancer Institute in 2015, Dr. Boyd held senior leadership positions at prominent cancer centers across the country, serving as the first executive officer of the Cancer Genome Institute at the Fox Chase Center in Philadelphia, Penn.

He also held numerous senior positions at Memorial Sloan-Kettering Cancer Center and served as a faculty member at the University of Pennsylvania and the National Institutes of Health.

Boyd says he and his wife are in the process of moving and hope to live in Lloyd Harbor, close to the Cold Spring Harbor laboratories.

I like to build things, Dr. Boyd said. Ive been in this cancer research and clinical care space for decades, and there is unparalleled opportunity here.

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Columbia Pediatrics Researchers Receive Seed Funding for Innovative Research – Columbia University Irving Medical Center

February 22nd, 2020 4:44 pm

Recipients of INF awards, from left, areSumeet Banker, Jennifer Woo-Baidal, Andrew Geneslaw, Julia Wynn, and Rebecca Hough. Not pictured: Michael DiLorenzo. (Photo: Charles Manley)

Six Columbia pediatrics researchers were awarded start-up funding from the Department of Pediatrics through a new Innovation Nucleation Fund. The recipients, announced during a department faculty meeting on Feb. 13, areSumeet Banker, MD, MPH,Michael DiLorenzo, MD, Julia Wynn, MS,Rebecca Hough, MD, PhD,Jennifer Woo-Baidal, MD, MPH, andAndrew Geneslaw, MD.

The fund wasestablished this year with contributions to the Department of Pediatrics from private donorsand is designed to bring a venture capital approach to supporting new research in childrens health.

The Innovation Nucleation Fund will allow our talented faculty the freedom to pursue innovative, bold ideas in research that could lead to the next major breakthrough in childrens health, saysJordan S. Orange, MD, PhD, the Reuben S. Carpentier Professor and Chair of the Department of Pediatrics at Columbia University Vagelos College of Physicians and Surgeons.

Awards of $10,000 to $50,000 were given to faculty whose projects demonstrated an ability to advance the departments mission of engaging in advocacy, clinical work, education, and basic or clinical translational research.

Advocacy

Sumeet Banker, MD, MPH,assistant professor of pediatrics in child and adolescent health, will study how to improve disparities in care and communication for children and families with limited proficiency in English.

Clinical Program

Michael DiLorenzo, MD,assistant professor of pediatrics in pediatric cardiology, will investigate the use of transcatheter-based imaging to treat lung problems caused by the accumulation of lymphatic fluid in children with congenital heart defects.

Education

Julia Wynn, MS, associate professor of genetic counseling in molecular genetics, will develop an interactive video educational tool to increase participation in pediatric genomics studies. Co-investigators on the project are Priyanka Ahimaz, MS, assistant professor of genetic counseling; Ilana Chilton, MS, lecturer in genetic counseling; Emily Griffin, MS, lecturer in genetic counseling; and Rebecca Hernan, MS, genetic counselor.

Basic/Translational Research

Rebecca Hough, MD, PhD,assistant professor of pediatrics in pediatric critical care medicine, will use imaging of live mouse lungs to better understand cell-to-cell communication underlying pediatric acute respiratory distress syndrome, with the goal of developing targeted therapies for the condition.

Clinical/Translational Research

Jennifer Woo-Baidal, MD, MPH, assistant professor of pediatrics in pediatric gastroenterology, hepatology, and nutrition, with co-investigator Dodi Meyer, MD, professor of pediatrics, will evaluate the implementation of Food FARMacia, a novel, clinically based food assistance program to prevent childhood obesity by tackling food insecurity in families with children under age 5.

Faculty INF Award

Andy Geneslaw, MD,instructor in pediatrics in pediatric critical care medicine, will use mobile technology to understand the neurodevelopment effect of severe respiratory failure in infants and toddlers.

A total of 25 proposals were submittedfor consideration by five senior faculty from the Department of Pediatrics.The application process was extremely competitive, and we received many superb proposals, says Orange. We look forward to seeing the impact of these brilliant researchers and their efforts in the near future.

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Columbia Pediatrics Researchers Receive Seed Funding for Innovative Research - Columbia University Irving Medical Center

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Tackling Alzheimer’s and dementia in New Mexico – KUNM

February 22nd, 2020 4:44 pm

University Showcase 2/21 8a: Alzheimers and dementia represent a growing crisis around the world and New Mexico faces many challenges in addressing these illnesses.

On this episode we highlight a conference organized by the Alzheimer's Foundation of America coming to the University of New Mexico on February 25.

It is open to the public and no tickets are required, but participants can register here.

We also talk with Dr. Gary Rosenberg, founder of the UNM Memory & Aging Center.

The center opened in 2016 and focuses on advancing research on dementia and helping expand care around the state.

And we check in one with Nicole Maphis, Ph.D candidate in UNMs Biomedical Sciences Graduate Program, who is working on a vaccine for Alzheimers with Kiran Bhaskar, an associate professor in UNMs Department of Molecular Genetics & Microbiology, and Bryce Chackerian, Professor and Vice Chair, Molecular Genetics and Microbiology. Find the previous interview we did with these researchers here.

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Tackling Alzheimer's and dementia in New Mexico - KUNM

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Shaping the future: Microbiologist’s career inspired by influential teacher – MSUToday

February 22nd, 2020 4:44 pm

Feb. 19, 2020

A Michigan State University scientist is determined to increase the number of women and girls going into STEM fields. Kayla Conner is a doctoral candidate in theDepartment of Microbiology and Molecular Geneticswho says she wouldnt be the student she is today if it werent for her high school chemistry teacher, Ms. Hardin.

Conner is part of MSUsBroadening Experiences in Scientific Training, an experimental program dedicated to empowering graduate student trainees to develop professional skills and experiences. Recently, reporters with WKAR News sat down with some of the BEST students to learn more about their inspiring life stories. Listen to the audio clip to hear Conners story in her own words and those of Hardin.

Conner is currently studying what happens to the placenta when a woman gets an infection during pregnancy and what that could mean for the fetus. Shes researching possible ways to stop some of the negative consequences that happen because of infection.

If a woman gets infected with any sort of ailment during pregnancy, whether it be the cold or the flu, it causes inflammation in the mother, says Conner. And that can lead to downstream effects, whether that is stillbirth, preterm labor, birth defects or even ailments later in life.

Conner was raised in Maynardville, Tennessee, and attended a small high school where she found the atmosphere to be less than encouraging and lacking resources for students who wanted to pursue higher education.

A lot of people have the mentality, Im from here so, therefore, I cant, and its really sad, she says. I really dont want people to have that mentality because even though you are from there you can do wonderful things. I dont think I would have had that drive without Ms. Hardin.

Conner looked up to her chemistry teacher and found encouragement to continue her studies.

She told me how well I was doing even when I felt like I wasnt, says Conner. I thought, Man, you know if she thinks I can do it, then maybe I can.

Hardin says that Conner gives her too much credit.

She has a scientific mind and shes curious, says Hardin. It was obvious to me. She had a natural talent for it. As a teacher, I encourage all my students, especially girls, to not look at science and math as something that boys do. You work at it. You keep plugging away and you can do it too.

For Conner, having women who have helped support her has been extremely important. Ive had women who told me that I can and who have helped me in every way they possibly can, she says. I think its important to give back and be that person for someone else. I go to the Girl Scout troops. I have a little outreach program where I do some hands-on activities and I give a talk. Its a fun time.

Only about 24 percent of the STEM workforce is made up of women. There have been studies that have shown that girls in lower education elementary and middle school show the same interest in STEM courses and enroll in courses at the same rates as their male student counterparts, but once it reaches the level of higher education, women do not seek out STEM courses as frequently as men do.

Conner recognizes the disconnect that is happening and strives to inspire talented women to pursue STEM careers.

Its not a mans game, Conner says. It is absolutely a womans game as well. We can be awesome scientists and be awesome mothers, friends and daughters and be whatever we want to be.

MSU BEST seeks to enhance trainees abilities to develop the confidence and competencies useful in navigating and choosing from diverse career opportunities.Learn more about becoming part of the BEST community.

Photos and video by Alec Gerstenberger.

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Home is where the heart lies: the amazing story of Chopin’s heart – The First News

February 22nd, 2020 4:44 pm

Bolesaw Bierut, the communist leader, hands over the casket containing Chopin's heart to Mayor of Warsaw Stanisaw Towiki in 1945. Public domain

When Chopin died in France at the early age of thirty-nine his famous deathbed wish was that his heart should be cut out from his body and sent to Poland.

Terrified of waking up in his own coffin, he said to his sister Ludwika, Swear to make them cut me open, so that I wont be buried alive.

This final morbid request set in motion an astonishing series of events connected with his heart that have lasted over 170 years.

They have involved his heart being smuggled into Tsarist-controlled Poland in a jar of cognac, lying for years in a junk yard, being seized, or perhaps saved, by the Germans during the Warsaw Uprising and finally being the subject of intriguing scientific analysis.

It was this last chapter that caught the attention of the world a few years ago, when Chopins heart was taken out of its casket from a pillar in the Holy Cross Church in Warsaw for the first time since October 1945.

It is common to hear in Poland that Chopin died of a broken heart that longed for its homeland. The real reason for his death, though, was widely attributed to tuberculosis. Yet, there have been doubts about the real cause for more than 170 years.

Chopin pictured in 1849. The composer was plagued by ill health for most of his life.Public domain

Chopin was sickly for most of his life. At the age of 28, he weighed just 45 kg and was diagnosed with tuberculosis, which was treated with fasting and drawing blood.

He often suffered from respiratory infections and coughed for most of his life. Throughout his last 10 years he took opium.

The report prepared by doctors upon his death no longer exists. However, accounts say that the cause of death was given as lung and laryngeal tuberculosis. Over the years, other hypotheses appeared, including cystic fibrosis.

Scientists thought that if they could examine his heart, they could finally determine the cause of his death.

After warnings that the alcohol in the jar containing the organ might have evaporated after 170 years, they finally got their chance when church bosses agreed to open the casket.

When a carefully selected conclave of churchmen and scientists met in secret late one April night in 2014 to open the casket, what they found was an enlarged and floppy heart, still submerged in an amber-brown liquid. This was most likely cognac, commonly used for tissue preservation in the 19th century.

Chopin's heart arriving in Warsaw in 1945.NAC

The researchers saw that the heart was covered with a fine coating of white fibrous materials. Small lesions were visible, the tell-tale symptoms of serious complications of tuberculosis.

The researchers concluded the musician had suffered from pericarditis, a rare complication of chronic tuberculosis. The diagnosis was published in the American Journal of Medicine at the end of 2017.

One of the authors, Professor Micha Witt, head of the Department of Molecular and Clinical Genetics of the Institute of Human Genetics of the Polish Academy of Sciences in Pozna, said: We didnt open the jar [] But from the state of the heart we can say, with high probability, that Chopin suffered from tuberculosis while the complication pericarditis was probably the immediate cause of his death.

The heart in a hermetically sealed crystal jar 16 centimetres high and 12 centimetres in diameter. The preserving liquid had lost at most half a centimetre.

The jar was located in a wooden box lined with lead panels. They did not open the jar. Instead, after a thorough visual examination, they strengthened the seal with bees wax.

One thing that they noticed was that the heart had suffered slight damage, probably from being buffeted on the journey from Paris to Warsaw.

An examination of the heart in 2014 came to the conclusion that Chopin had died from complications caused by TB.hopin's heart I should credit all those guys? Micha Witt, Artur Szklener, Wojciech Marchwica, Tadeusz Dobosz

The journey is believed to have taken place in 1850. At the time Poland was a constituent part of the Russian empire. Chopin was regarded as a national hero, so to avoid difficulties with the Tsarist authorities Chopins sister Ludwika decided to smuggle the heart into Warsaw. Legend says that she hid the jar with his heart under her skirt.

It was Chopin's wish to be laid to rest with his family in Powzki cemetery in Warsaw. However, as only his heart came back to the country, the choice was made to give it to the Holy Cross Church.

This was where all the family celebrations had been held, it was the Chopin family's parish church and it was the most important church in Warsaw.

Unfortunately, the church did not want the composers heart. His relationship with the progressive writer George Sand, who changed lovers like pairs of gloves, was deemed a scandal by the church hierarchy.

The heart of one of the worlds greatest ever composers was therefore dumped in part of the crypt where broken odds and ends were kept, in effect a junkyard.

It was probably thanks to this that it survived the plunder of the church by Russians soldiers during the 1863 January Uprising. In 1880, and epitaph was finally ordered. However in the intervening years, people had forgotten exactly where the heart was.

The current resting place of the heart in the Holy Cross Church.Kalbar/TFN

Eventually, a local journalist tracked it down to the crypt and the heart was moved to the main church with great honour.

His heart stayed there until the Warsaw Uprising in 1944 when it faced its greatest danger. But what exactly happened to Chopins heart during that turbulent time remains a mystery.

According to the wartime account of Father Alojzy Niedziela, a young priest at the Holy Cross Church, a German chaplain entered the church in early August and said that eventually the fighting would engulf the church. He asked therefore that Chopins heart be removed for its safekeeping.

There also exists a German newsreel film dated September 9, 1944 showing SS General Erich von dem Bach-Zelewski, accompanied by a unit standing to attention, giving the casket with Chopin's heart to Archbishop Antoni Szlagowski.

The Archbishop is said to have taken the heart to Milanwek and hidden it inside a piano until October 17, 1945, when it returned to Warsaw.

Some stories claim that a German priest may have removed the heart from the church during the war, thus saving it from destruction.Leszek Szymaski/PAP

However, Home Army reports say that the heart was in their possession when they seized the church around August 23, and that it only fell into German hands when they regained control of the church a few days later.

Chopin experts have not been able to reconcile the conflicting accounts to this day.

The heart finally came back to the Holy Cross Church on the anniversary of the composers death on October 17, 1945.

After all this turbulence, it looks likely that Chopins heart can now rest peacefully until the next scheduled viewing in 50 years.

However, some scientists are keen to open it and carry out DNA tests. Professor Witt opposes this idea though.

Genetic testing would require the jar to be opened, which could expose the preparation to serious damage as the atmosphere inside can change dramatically. This can have a very bad effect on what is inside, he said.

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Home is where the heart lies: the amazing story of Chopin's heart - The First News

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Kallyope Inc. Appoints Peter Hecht to Board of Directors – BioSpace

February 22nd, 2020 4:44 pm

NEW YORK, Feb. 20, 2020 /PRNewswire/ -- Kallyope Inc., a leading biotechnology company focused on identifying and pursuing therapeutic opportunities involving the gut-brain axis, today announced that Peter Hecht, Ph.D., CEO of Cyclerion Therapeutics, has been appointed to the company's Board of Directors.

Prior to joining Cyclerion in 2019, Peter was co-founder and CEO of Ironwood Pharmaceuticals from 1998 to 2019. Under his leadership, Ironwood grew into a fully integrated research, development and commercial organization with more than 700 employees. During his tenure the company discovered, developed and commercialized LINZESS (linaclotide) globally for irritable bowel syndrome with constipation and chronic constipation. In 2019, Peter led the tax-free separation of Ironwood's non-gastrointestinal (GI) assets and R&D team into Cyclerion, enabling Ironwood to be a profitable GI therapeutics-focused leader. After completion of the spin-off, Hecht joined Cyclerion as its first CEO. He holds a Ph.D. in molecular biology from the University of California at Berkeley and was a post-doctoral research fellow at the Whitehead Institute.

"It is an exciting time to join Kallyope," said Hecht. "Their unique platform of integrated technologies has led to a new understanding of gut-brain circuits that has, in turn, resulted in the discovery of novel approaches to diseases of high unmet need in multiple therapeutic areas. I look forward to working with the team as the company begins to advance its portfolio of programs towards the clinic."

"We are delighted to welcome Peter to our Board of Directors at this pivotal time," said Nancy Thornberry, CEO of Kallyope. "As we progress our lead programs and expand our pipeline and novel platform, Peter's experience in building innovation-driven biotech startups into mature biopharmaceutical companies will be invaluable for us."

About Kallyope Inc.

Kallyope, headquartered at the Alexandria Centerfor Life Science in New York City, is a biotechnology company dedicated to unlocking the therapeutic potential of the gut-brain axis. The company's cross-disciplinary team integrates advanced technologies in sequencing, bioinformatics, neural imaging, cellular and molecular biology, and human genetics to provide an understanding of gut-brain biology that leads to transformational therapeutics to improve human health. The company's founders are Charles Zuker, Ph.D., Lasker Award winner Tom Maniatis, Ph.D., and Nobel laureate Richard Axel, M.D. For more information visitwww.kallyope.com.

Contact

Danielle Cantey(202) 337-0808dcantey@gpg.com

Morgan Warners(202) 337-0808mwarners@gpg.com

View original content to download multimedia:http://www.prnewswire.com/news-releases/kallyope-inc-appoints-peter-hecht-to-board-of-directors-301008114.html

SOURCE Kallyope Inc.

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Kallyope Inc. Appoints Peter Hecht to Board of Directors - BioSpace

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U of T and Sunnybrook virologists work on tools to combat coronavirus outbreak – News@UofT

February 22nd, 2020 4:44 pm

In order to contain a virus, its important to know exactly what youre dealing with and the COVID-19 coronavirus is no different.

One of the key tools to try to contain or limit transmission of infectious diseases is case identification, saysSamira Mubareka, a virologist in the University of Torontos Faculty of Medicine and at Sunnybrook Health Sciences Centre.

If you identify cases, then you can contain them. If you miss them, then you dont.

Mubareka and her colleagueRobert Kozak, both in U of Ts department of laboratory medicine and pathobiology, are part of a local working group of scientists who are researching the novel coronavirus outbreak and are developing a suite of tools to control it.

One of their current projects involves using the latest in whole-genome sequencing technology to help hospitals characterize the virus more quickly. Their work may help to track the viruss evolution and trace its spread.

If the viruss genome was a book, were going to figure out its entire story, Kozak says.

Mubareka and Kozak collected specimens of the coronavirus from the first confirmed case in Canada, an adult male who was treated and eventually discharged from Sunnybrook after returning from Wuhan, China the epicentre of the outbreak. Two more cases in Ontario have since been confirmed: the original patients wife, who accompanied him to China, and a woman in her 20s in London, Ont. who had also traveled to Wuhan.

Worldwide, there are more than 73,300 confirmed cases ofCOVID-19 as of Feb. 18. More than 1,800 have died.

Robert Kozak, pictured here in the lab, andSamira Mubareka say their teams work will enable front-line hospital staff to run a test on-site, helping to identify and triage patients more efficiently (photo by Nick Iwanyshyn)

In Canada, where there are so far seven confirmed cases, health authorities say the risk remains low. But Mubareka and Kozak are preparing for any possible scenario.

You put a smoke alarm in your house even if you hope theres no fire, says Kozak, who previously worked at the National Microbiology Laboratory in Winnipeg on Ebola and Zika.

Part of the teams work involves developing a test that will speed up the characterization of the virus. Currently, patient samples in Ontario are sent from local hospitals by courier to the Public Health Ontario lab in downtown Toronto for testing, and to the national lab in Winnipeg for confirmation.

The process can take a few days, depending on the hospitals distance from the labs and test volumes.

Mubareka and Kozak say their teams work in collaboration with McMaster University and infectious disease expert Allison McGeer of U of Ts Dalla Lana School of Public Health, Faculty of Medicine and Mount Sinai Hospital will enable front-line hospital staff to run a test on-site, helping to identify and triage patients more efficiently. The test involves using swabs from a patients nose and throat to do genomic testing to sequence the virus.

If theyre negative, you can take them [the patients] out of precautions and maybe even send them home, Kozak says. If theyre positive, then you can again take the appropriate precautions to isolate them and do everything else that needs to be done.

The researchers hope they can adapt the approach for mini-sequencers the size of a cell phone, so it can be used more widely.

Vivek Goel,U of Ts vice-president, research and innovation, and strategic initiatives,says the university worked quickly to mobilize support for the project.

With its cross-disciplinary expertise and close relationships with area hospitals, the university recognizes that its uniquely positioned to play a leadership role when it comes to these sorts of global health issues, Goel says.

We also have the benefit of having experienced the SARS outbreak in Toronto in 2003, so we know first-hand how important this sort of research can be.

The genomic testing being performed by the U of T-led group could also help researchers get a fuller picture of the mysterious illness.

Although genomic sequences of the virus were published and shared in public databases, many were deposited soon after the first cases were identified in Chinas Hubei province, according to Mubareka.

The problem is that was early on before it started going from person to person-to-person, she says, noting that viruses mutate.

There are only about 50 sequenced genomes of the virus, adds Kozak for about 48,000 confirmed cases.

Youre not getting a great snapshot, he says. Its tough to really understand a lot about the virus.

Among the nagging questions about COVID-19 that U of T and Sunnybrook researchers hope to answer are how long patients remain contagious and if the amount of the virus present in respiratory secretions is proportional to its severity.

Their work may help others understand how the virus spreads from point A to point B, and if its changing in ways that make it more dangerous.

The research team includes U of T students likeNatalie Bell, a second-year masters student in laboratory medicine and pathobiology who is also working with Mubareka on a project related to influenza from swine.

Its really interesting to see science happen in real time, especially being part of Sams lab [and] to see her involvement and the movement from lab to policy work, and how it impacts public health, Bell says.

Mubareka and Kozak plan to upload the sequencing data to public servers and share it with the world to help with epidemiological studies and vaccine design.

We will build global capacity any way that we can, Kozak says.

Mubareka and Kozak say their work was made possible thanks in part to the McLaughlin Centre, which provided emergency funding for the project. We have no shortage of ideas of things we can do to hopefully make a difference, Kozak says, but you always need someone to provide the resources to do it.

Stephen Scherer, the director of the McLaughlin Centre at U of T and a University Professor in the department of molecular genetics, says the centre wanted to make sure the researchers had the necessary funds to do their work in time.

Nobody is busier right now than this group, so we wanted to make the process as easy as possible for them, Scherer says. We also wanted these researchers to know the rest of us value their efforts to keep us safe.

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U of T and Sunnybrook virologists work on tools to combat coronavirus outbreak - News@UofT

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