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Be Strong and Proud on Rare Disease Day – Pain News Network

March 1st, 2020 9:46 am

The National Institutes of Health is coordinating panel discussions on Friday, February 28 in Bethesda, MD to improve diagnosis and treatment, expand clinical trial resources, and increase awareness of rare diseases.

In all, NORD lists over 400 events in 106 countries marking Rare Disease Day, including conferences, research presentations, exhibits, walks, rallies and a variety of fundraisers.

Rare Disease Day started in 2008 with the first events held in Canada and Europe. The date February 29 was chosen because it is rare (Rare Disease Day is on February 28 in non-leap years).

Rare diseases and disorders often go undiagnosed and untreated. Due to their rarity, expertise, treatment and resources are limited for people living with a rare disease, who can also face discrimination at work and school.

Research on rare diseases can actually help improve understanding of more common disorders and lead to new treatments. For instance, Yale neuroscientist Dr. Stephen Waxman discovered the gene SCN9A and its role in two painful hereditary neuropathies. Treatments for these disorders may help people with many other forms of peripheral neuropathy, as Waxman explains in his book, Chasing Men on Fire.

Moreover, rare diseases are often misunderstood. They do not look like typical illness and may require unusual forms of medical care. So Rare Disease Day also represents a chance to raise awareness about the importance of research, specialist centers, and healthcare professionals who work on such disorders.

Although most rare diseases do not have a cure, they can all be managed and patient lives improved. Rare Disease Day is an opportunity to focus on promising research, improving patients lives, and promoting action.

Roger Chriss lives with Ehlers Danlos syndrome and is a proud member of the Ehlers-Danlos Society. Roger is a technical consultant in Washington state, where he specializes in mathematics and research.

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Study by UC San Diego Health Sciences finds difference in breast milk concentrations impacts growth up to age 5 – Breastfeeding affects infant growth…

March 1st, 2020 9:45 am

Study by UC San Diego Health Sciences finds difference in breast milk concentrations impacts growth up to age 5

San Diego Community News Group

Breastfeeding affects infant growth and, researchers have found, helps prevent obesity, both in childhood and later in life. However, the components of breast milk responsible for these beneficial effects remain mostly a mystery.

Human milk is an elaborate blend of proteins, fats, minerals, and vitamins, plus complex sugar molecules called human milk oligosaccharides or HMOs. There are approximately 150 types of HMOs. Like thumb and tongue prints, the combination and concentration of HMOs is unique to each nursing mother.

In a new study, published in the Feb. 18, 2020, online issue of "The American Journal of Clinical Nutrition," researchers at University of California San Diego School of Medicine confirmed the findings of previous pilot studies that found an association between HMO concentrations and infant weight and body composition.

The earlier pilot studies looked at a smaller, combined cohort of approximately 30 infants who were exclusively breastfed and who displayed excessive weight gain over a period of six months. The UC San Diego study examined a much larger cohort of 802 mothers and their children, part of the longitudinal Steps to Healthy Development of Children (STEPS) study, led by researchers at the University of Turku in Finland. The children were examined from birth to age 5.

The researchers found that high concentrations of one HMO called 2-Fucosyllactose (2FL) and low concentrations of another HMO known as Lacto-N-neotetraose (LNnT) were associated with growth in infancy and early childhood. Depending upon concentrations of HMOs in mothers milk, but independent of the mothers pre-pregnancy body mass index or duration of breastfeeding, infant height and weight can vary by half a standard deviation. Standard deviation is a measure of how spread out numbers are.

We were surprised by the magnitude of the association, said senior author Lars Bode, Ph.D., professor of pediatrics at UC San Diego School of Medicine and director of the Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence. The impact persisted long after actual exposure to HMOs during breastfeeding. Our analytical platform allows us to measure and associate individual HMOs with specific health and development outcomes.

HMOs are natural prebiotics that contribute to the shaping of the infant gut microbiome, which may affect health and disease risk. But they also act independently of the microbiome, protecting the infant from diseases, such as infectious diarrhea or necrotizing enterocolitis, a serious condition that impacts the intestine of premature infants. HMOs potentially also reduce the risk for non-communicable diseases, such as asthma, allergies, and obesity later in life.

Our goal is to generate a deep mechanistic understanding of how HMOs in a moms milk can contribute to infant health and development. Although we are only at the very beginning, the generated knowledge provides fascinating new opportunities, said Bode. Some HMOs could help infants who are behind the growth curve; other HMOs could do the opposite and help lower the risk of childhood obesity. We could even imagine applying HMOs as novel therapeutics for adults who either need to gain weight or suffer from overweight and obesity.

Bode said the study is also an example of how data can help guide the development of HMO blends for different products promoting health. We could tailor HMO composition in products based on actual scientific evidence and desired outcomes. Much like personalized medicine.

The association results from cohort studies are an impactful way to generate new hypotheses, said the researchers, especially if several different cohorts show very similar associations. However, association studies do not prove causality. Bode said his teams next steps include bringing the data back to the lab to test whether or not HMOs, either alone or in combination, affect growth and to pinpoint the underlying mechanisms.

Co-authors include: Chloe Yonemitsu and Julia Gupta, UC San Diego; Hanna Lagstrm, Samuli Rautava, Helena Ollila, Anne Kaljonen and Olli Turta, University of Turku; and Johanna Mkel, Tampere University Hospital.

Full study:https://doi.org/10.1093/ajcn/nqaa010

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Award-winning Prime Healthcare provides exceptional, personalized care for patients – Jersey’s Best

March 1st, 2020 9:45 am

Prime Healthcare utilizes the latest in diagnostic testing, state-of-the-art surgical and non-surgical treatments, the most advanced technology, research, residency programs and a compassionate staff to create five award-winning hospitals that provide comprehensive care for residents of Essex, Morris, Passaic, Sussex and Warren counties.

Prime Healthcare hospitals include:

Services available at all Prime Healthcare campuses include but are not limited to:

Saint Clares Health

Their multidisciplinary team of physicians, staff and volunteers at Saint Clares Denville Hospital, Saint Clares Dover Hospital and Saint Clares Behavioral Health are committed to providing the most advanced treatments and technology in a patient-centered environment. Saint Clares Health has been recognized for its award-winning care, receiving Pathway to Excellence designation, achieving Five Star Rating one of only two hospitals in New Jersey from the Centers for Medicare and Medicaid, achieving Leapfrog A Rating for patient safety, and being accredited as a Comprehensive Center by the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program. Saint Clares Behavioral Health provides a comprehensive range of emergency services, inpatient and outpatient programs, a substance abuse walk-in program, and one of the areas only psychiatric medical care units located at Saint Clares Dover Hospital. The psychiatric medical care unit allows patients to stay in one unit to receive their psychiatric and medical care. Saint Clares Center for Cancer Care offers the latest in radiation treatment close to home. TrueBeam Radiotherapy System gives patients treatment that is powerful and precise, minimizing damage to surrounding tissue and in some cases, less than five visits. Emergency services are available at two convenient locations Denville and Dover and have the shortest wait times in the area. Outpatient services include rehabilitation services, cardiac rehabilitation, breast services, laboratory, and radiology. For more information about Saint Clares services, visit saintclares.com.

Saint Marys General Hospital

St. Marys General Hospital is a community-based tertiary medical center that emphasizes quality, compassionate care. Fully accredited by The Joint Commission, St. Marys General is an award winning acute care hospital offering a broad range of cardiovascular services as well as a comprehensive program for cancer care. St. Marys General also is a center of excellence for maternal-child health and outpatient behavioral health services. It is the recipient of various Healthgrades awards, including the Excellence Award for Gynecologic Surgery. St. Marys General is a State Designated Heart Center, Certified Stroke Center and is The Joint Commission Top Performer on Key Quality Measures for three consecutive years. It is the only hospital in Passaic County with over 550 physicians and 1,200 employees one of the largest employers in the county. Every member of the St. Marys General team is committed to providing respectful, personalized, high-quality care. The hospitals goal is to satisfy patients needs and exceed their expectations. St. Marys General Hospital is a member of the Prime Healthcare System family, which has been lauded as a Top 15 Healthcare System by Truven Health Analytics. To learn more about St. Marys General Hospital, visit http://www.smh-nj.com.

Saint Michaels Medical Center

Saint Michaels Medical Center is a 358-bed regional tertiary-care, teaching and research hospital located in the heart of Newarks thriving business and university community. For more than 150 years, the hospital has served the health care needs of Newark residents as well as the surrounding community. Saint Michaels is a major teaching hospital affiliated with New York Medical College, offering an internal medicine residency as well as fellowships in cardiology, interventional cardiology, gastroenterology, oncology, infectious disease, pulmonary and critical care. The hospital has recently invested millions of dollars in new telemetry equipment throughout the hospital, a top-of-the-line Varian TrueBeam Radiotherapy System in its Cancer Center, and two advanced, state-of-the-art catheterization laboratories that allow the hospital to offer Transcatheter Aortic Valve Replacement (TAVR), a minimally invasive cardiac procedure for patients suffering from a faulty heart valve condition known as cardiac stenosis. Saint Michaels is one of Americas 100 Best Hospitals for Cardiac Care for two consecutive years (2018 and 2019). The hospital is ranked among the top 10% in the nation for cardiac surgery by Healthgrades and is a recipient of Healthgrades 2019 Cardiac Surgery Excellence Award and Cardiac Care Excellence Award. Healthgrades also named Saint Michaels a Five Star Recipient for coronary bypass surgery, treatment of heart attack, treatment of heart failure and for pacemaker procedures. Saint Michaels is a leader in the treatment of womens health issues. The hospitals highly skilled team of obstetrician/gynecologists and primary care physicians provide patient-focused, compassionate quality care using state-of-the-art technology in line with Saint Michaels mission to heal with dignity and respect. Saint Michaels Emergency Department has among the shortest wait times in the Greater Newark area and provides a FastTrack option for patients with less serious ailments. Saint Michaels has received a grade of A for patient safety for the last three periods from Leapfrog as well as the Patient Safety Excellence Award from Healthgrades.

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Top 10 Strategic Technology Breakthroughs That Will Transform Our Lives – Analytics Insight

March 1st, 2020 9:45 am

The world is surrounded by technology technology that makes our jobs easy, the technology that makes our commute easy, the technology that makes out communication easy and so on. Hence, such advancements have turned into a boon to our lives while easing out numerous works that would conventionally take a long time to complete. Now that we look back we see so many new technologies have taken over the world that its nearly impossible to enlist them at once. And how further advancements will impact our lives in new ways we cannot even imagine.

MIT has drafted a list of top 10 strategic technology breakthroughs that will revolutionize our lives in the coming years.

An internet based on quantum physics will soon enable inherently secure communication. A team led by Stephanie Wehner, at Delft University of Technology, is building a network connecting four cities in the Netherlands entirely by means of quantum technology. Messages sent over this network will be unhackable.

The Delft network will be the first to transmit information between cities using quantum techniques from end to end.The technology relies on a quantum behavior of atomic particles called entanglement. Entangled photons cant be covertly read without disrupting their content.

Heres a definition of a hopeless case: a child with a fatal disease so exceedingly rare that not only is there no treatment, theres not even anyone in a lab coat studying it. Too rare to care, goes the saying.

Thats about to change, thanks to new classes of drugs that can be tailored to a persons genes. If an extremely rare disease is caused by a specific DNA mistakeas several thousand aretheres now at least a fighting chance for a genetic fix through hyper-personalized medicine. One such case is that of Mila Makovec, a little girl suffering from a devastating illness caused by a unique genetic mutation, who got a drug manufactured just for her. Her case made the New England Journal of Medicine in October after doctors moved from a readout of her genetic error to treatment in just a year. They called the drug milasen, after her. The treatment hasnt cured Mila. But it seems to have stabilized her condition: it has reduced her seizures, and she has begun to stand and walk with assistance.

Milas treatment was possible because creating a gene medicine has never been faster or had a better chance of working. The new medicines might take the form of gene replacement, gene editing, or antisense (the type Mila received), a sort of molecular eraser, which erases or fixes erroneous genetic messages. What the treatments have in common is that they can be programmed, in digital fashion and with digital speed, to correct or compensate for inherited diseases, letter for DNA letter.

Last June Facebook unveiled a global digital currency called Libra. The idea triggered a backlash and Libra may never launch, at least not in the way it was originally envisioned. But its still made a difference: just days after Facebooks announcement, an official from the Peoples Bank of China implied that it would speed the development of its own digital currency in response. Now China is poised to become the first major economy to issue a digital version of its money, which it intends as a replacement for physical cash.

The first wave of a new class of anti-aging drugs has begun human testing. These drugs wont let you live longer (yet) but aim to treat specific ailments by slowing or reversing a fundamental process of aging.

The drugs are called senolyticsthey work by removing certain cells that accumulate as we age. Known as senescent cells, they can create low-level inflammation that suppresses normal mechanisms of cellular repair and creates a toxic environment for neighboring cells.

The universe of molecules that could be turned into potentially life-saving drugs is mind-boggling in size: researchers estimate the number at around 1060. Thats more than all the atoms in the solar system, offering virtually unlimited chemical possibilitiesif only chemists could find the worthwhile ones.

Now machine-learning tools can explore large databases of existing molecules and their properties, using the information to generate new possibilities. This AI enabled technology could make it faster and cheaper to discover new drug candidates.

Satellites that can beam a broadband connection to internet terminals. As long as these terminals have a clear view of the sky, they can deliver the internet to any nearby devices. SpaceX alone wants to send more than 4.5 times more satellites into orbit this decade than humans have ever launched since Sputnik.

These mega-constellations are feasible because we have learned how to build smaller satellites and launch them more cheaply. During the space shuttle era, launching a satellite into space cost roughly US$24,800 per pound. A small communications satellite that weighed four tons cost nearly $200 million to fly up.

Quantum computers store and process data in a way completely different from the ones were all used to. In theory, they could tackle certain classes of problems that even the most powerful classical supercomputer imaginable would take millennia to solve, like breaking todays cryptographic codes or simulating the precise behavior of molecules to help discover new drugs and materials.

There have been working quantum computers for several years, but its only under certain conditions that they outperform classical ones, and in October Google claimed the first such demonstration of quantum supremacy. A computer with 53 qubitsthe basic unit of quantum computationdid a calculation in a little over three minutes that, by Googles reckoning, would have taken the worlds biggest supercomputer 10,000 years, or 1.5 billion times as long. IBM challenged Googles claim, saying the speedup would be a thousandfold at best; even so, it was a milestone, and each additional qubit will make the computer twice as fast.

AI has a problem: in the quest to build more powerful algorithms, researchers are using ever greater amounts of data and computing power and relying on centralized cloud services. This not only generates alarming amounts of carbon emissions but also limits the speed and privacy of AI applications.

But a countertrend of tiny AI is changing that. Tech giants and academic researchers are working on new algorithms to shrink existing deep-learning models without losing their capabilities. Meanwhile, an emerging generation of specialized AI chips promises to pack more computational power into tighter physical spaces, and train and run AI on far less energy.

In 2020, the US government has a big task: collect data on the countrys 330 million residents while keeping their identities private. The data is released in statistical tables that policymakers and academics analyze when writing legislation or conducting research. By law, the Census Bureau must make sure that it cant lead back to any individuals.

But there are tricks to de-anonymize individuals, especially if the census data is combined with other public statistics.

So the Census Bureau injects inaccuracies, or noise, into the data. It might make some people younger and others older, or label some white people as black and vice versa while keeping the totals of each age or ethnic group the same. The more noise you inject, the harder the de-anonymization becomes.

Differential privacy is a mathematical technique that makes this process rigorous by measuring how much privacy increases when noise is added. The method is already used by Apple and Facebook to collect aggregate data without identifying particular users.

Ten days after Tropical Storm Imelda began flooding neighborhoods across the Houston area last September, a rapid-response research team announced that climate change almost certainly played a role.

The group, World Weather Attribution, had compared high-resolution computer simulations of worlds where climate change did and didnt occur. In the former, the world we live in, the severe storm was as much as 2.6 times more likelyand up to 28% more intense.

Earlier this decade, scientists were reluctant to link any specific event to climate change. But many more extreme-weather attribution studies have been done in the last few years, and rapidly improving tools and techniques have made them more reliable and convincing.

This has been made possible by a combination of advances. For one, the lengthening record of detailed satellite data is helping us understand natural systems. Also, increased computing power means scientists can create higher-resolution simulations and conduct many more virtual experiments.

These and other improvements have allowed scientists to state with increasing statistical certainty that yes, global warming is often fueling more dangerous weather events.

By disentangling the role of climate change from other factors, the studies are telling us what kinds of risks we need to prepare for, including how much flooding to expect and how severe heatwaves will get as global warming becomes worse. If we choose to listen, they can help us understand how to rebuild our cities and infrastructure for a climate-changed world.

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Majority of blindness could be avoided with regular eye check-ups – Gulf News

March 1st, 2020 9:42 am

Optomeds handheld fundus cameras are sold in over 60 countries around the world and used by major public hospitals, primary care centres and private clinics Image Credit: Supplied Highlights

Our eyes are considered the most important sense. Even though most of us recognise the importance of our sight, many of us are not aware of the importance of systematic eye checks and we are not protecting this valuable sense well enough

Sight is our most precious sense. Most of what we learn is through our eyes and we fear to lose our vision more than any other sense.(1)

Studies have shown that vision impairment is often associated with various negative health outcomes and poor quality of life.(2) Still, approximately 1.3 billion people globally live with some form of vision impairment.(3) Over 80 per cent of all vision impairment could be avoided by early detection and appropriate treatment. Therefore, offering effective and accessible eye care services is key for controlling visual impairment including blindness.(4)

Need for better access to eye examinations

Optomed Plc was founded in 2005 to meet the challenge of more accessible and affordable eye screening devices. Seppo Kopsala, the CEO and founder of Optomed states: In the time when Optomed was established, retinal examinations and eye screenings were performed mainly on the hospital level. The service was not available in rural areas, low-income countries or with patient groups that are not able to travel and sit in front of a tabletop fundus camera. This poor access to eye examinations was the reason why we started developing a portable, handheld fundus camera so that the service would be available to all individuals worldwide and we could help healthcare professionals to prevent blinding eye diseases by early detection.

Today, Optomed is a world-leading manufacturer of handheld fundus cameras and screening management software with integrated Artificial Intelligence for diagnosing the images. Our cameras are sold in over 60 countries globally and we also make handheld fundus cameras to other major medical technology companies. Optomed cameras are being used by major public hospitals, primary care centres, private clinics, non-government and charity organisations around the world and, they have medical device approvals in all key markets, e.g. CE approval, FDA approval, and Chinese CFDA approval. Our mission at Optomed is to provide innovative and affordable eye-screening solutions to prevent blindness and make eye-screening available for all.

Eyes are a gateway to examining blood vessels

Blood vessels can be observed non-invasively in eyes, so they serve as a window to examine signs of several diseases. Today, fundus imaging is routinely used to screen for eye diseases such as diabetic retinopathy, and to seek signs of age-related macular degeneration and glaucoma. With the rise of artificial intelligence, new ways to exploit retinal images have been found especially within neurology and cardiology to study diseases like dementia, stroke and cardiovascular diseases. (5-8)

It is easy to claim that the importance of regular eye check-ups and fundus imaging will increase in the future, thanks to its simplicity, non-invasive characteristics, and the increasing use of Artificial Intelligence for image analysis. Optomed has the right products and know-how to help healthcare providers globally to organise effective and affordable eye-screening programs and together we can aim to stop the growth of preventable blindness.

For more information contact:

Niina Huikuri,Vice President Marketing |+358 40 535 0998 |niina.huikuri@optomed.com

Laura Piila,Vice President Devices | +358 40 588 1187 | laura.piila@optomed.com

Yrttipellontie 1,90230 Oulu, Finland |www.optomed.com

1. J.Zaba. Journal of Behavioral Optometry, Volume 22, 2011

2. Making Eye Health a Population Health Imperative: Vision for Tomorrow. National Academies of Sciences, Engineering, and Medicine. National Academies Press (US); 2016 Sep 15

3. Seth R Flaxman et al., Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis. Lancet Glob Health, October 2017.

4. WHO. Vision impairment and blindness. Media centre, Fact sheet, October 2017, http://www.who.int/mediacentre/factsheets

WHO. Prevention of blindness from diabetes mellitus. Report of a WHO consultation

5. Cheung CY, Chen C, Wong TY (2015) Ocular fundus photography as a tool to study stroke and dementia. Semin Neurol. 35(5): 481-490.

6. McGrory S, Cameron JR, Pellegrini E, Warren C, Doubal FN, Deary IJ, Dhillon B, Wardlaw JM, Trucco E, MacGillivray TJ (2016) The application of retinal fundus camera imaging in dementia:

A systematic review. Alzheimers Dement (Amst). 6:91-107.

7. Ting DSW, Pasquale LR, Peng L, Campbell JP, Lee AY, Raman R, Tan GSW, Schmetterer L, Keane PA, Wong TY (2018) Artificial intelligence and deep learning in ophthalmology.

Br J Ophthalmol Epub ahead of print: 08/11/2018.

8. Poplin R, Varadarajan AV, Blumer K, Liu Y, McConnell MV, Corrado GS, Peng L, Webster DR (2018) Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning.

Nat Biomed Eng 2, 158-164.

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Prevent Blindness Offers New Educational Resources on Uveitis and Keratitis for Rare Disease Day – InvisionMag

March 1st, 2020 9:42 am

(PRESS RELEASE) CHICAGO In observance of Rare Disease Day on Feb. 29, 2020, Prevent Blindness, the nations oldest volunteer eye health organization, is offering educational resources on uveitis, an inflammatory eye disease. Uveitis is a general term describing a group of inflammatory diseases that produces swelling and destroys eye tissues in the uvea (the middle layer of the eye that contains most blood vessels), according to the National Eye Institute. Uveitis is caused by an eye injury or surgery, an infection, autoimmune diseases or systemic inflammatory disorders that affect the whole body, or the cause can be unknown.

In addition, Prevent Blindness offers a new patient education resource dedicated to keratitis, an inflammation of the cornea. The cornea is the clear, protective outer layer of the eye.

Prevent Blindness offers dedicated web pages at http://www.preventblindness.org/uveitis and http://www.PreventBlindness.org/keratitis, as well as a new educational video. Downloadable fact sheets are also available, including, Uveitis Causes, Uveitis Facts, Uveitis Patient Guide, and Keratitis. Development of these new resources was supported by a grant from Mallinckrodt Pharmaceuticals.

Without early detection and treatment, inflammatory eye diseases can lead to permanent vision loss. The prevalence of inflammatory eye diseases can vary based on the type and cause of the condition. Uveitis causes about 30,000 new cases of legal blindness annually in the United States and accounts for about 1015 percent of all cases of total blindness in the country.

Uveitis symptoms may occur quickly in an acute form (lasts less than six weeks) or slowly in a chronic form (lasts longer than six weeks). Symptoms may affect one or both eyes.

Uveitis can affect anyone at any age, but it is most commonly seen in working age adults, and has a higher prevalence in women. In addition, smoking may increase the risk of getting uveitis.

General eye inflammation occurs in response to infection, allergies, autoimmune disorders, irritation, injury, or trauma to the eyes, eyelids, or surrounding tissues. Most cases of eye inflammation can be successfully treated. However, in some cases there can be an eye disease present, which can pose a threat to eyesight.

According to a report from the Centers for Disease Control and Prevention (CDC), an estimated 930,000 doctors office and outpatient clinic visits and 58,000 emergency department visits for keratitis or contact lens disorders occur annually. And, episodes of keratitis and contact lens disorders cost an estimated $175 million in direct health care expenditures.

Wearing contact lenses, especially sleeping in the lenses, increases the risk of both infectious and noninfectious keratitis. The risk increases from wearing them longer than prescribed, improper cleaning and disinfection, and wearing contact lenses while exposed to water (such as in swimming pools or hot tubs).

Inflammatory eye diseases are very serious and can lead to significant vision loss and even blindness, said Jeff Todd, president and CEO of Prevent Blindness. It is very important to have regular, comprehensive eye exams, to help catch vision issues early on. We encourage everyone to make an appointment with an eye doctor immediately if you experience any sudden vision changes to help save your sight in the future.

For more information on uveitis, please call Prevent Blindness at (800) 331-2020 or visit https://www.preventblindness.org/uveitis. For more information on keratitis, visit https://www.preventblindness.org/keratitis. For a listing of vision care financial assistance programs in English or Spanish, visit https://www.preventblindness.org/vision-care-financial-assistance-information.

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Johnson: Moral blindness and the fall of Jean Vanier – Ottawa Citizen

March 1st, 2020 9:42 am

In this file photo taken on March 11, 2015, French founder of the Communaut de l'Arche (Arch community) Jean Vanier speaks during a press conference in central London. JUSTIN TALLIS / AFP via Getty Images

The news about Jean Vanier sexually abusing at least six women was delivered to me Saturday morning in an email containing two words: Aw sh .

Its devastating news for women. We all knew instantly that this one was different. This is not some arrogant Harvey Weinstein we can enjoy being taken down. This one forces us to wrestle with the problem at a much deeper level. I spent the day on the phone with friends.

For women, living in a patriarchy requires constant vigilance. We try to steer clear of the obvious misogynists. We try to avoid being beaten or murdered by the Jekyll and Hydes who reveal their true selves only after marriage and children. We dodge harassment in the workplace and on the street; fend off unwanted sex in our dating lives. We try to pretend the world is not awash in violent pornography that dehumanizes and degrades us as a class; try not to know that some of the men we love are turned on by our subordination.

We have our guard up all the time. So when a great humanitarian, champion of the marginalized and dispossessed, friend of the poorest of the poor, is revealed to have sexually abused women, it feels completely hopeless. Like there is no safe place for us anywhere on the planet. How do we reconcile Vaniers magnificent humanity and vision of the common good with his abuse of women? Put very simply, his vision of justice did not include women.

I go to the basement and rummage through boxes until I find the two letters I received from Jean Vanier. I wrote to Vanier in 1999 after hearing a broadcast of his Massey Lecture, On Being Human. He spoke inspiringly about forgiveness as the path to peace. About how we are all wounded, hurting, trapped behind walls and needing to reach out for each other. It made me want to go out and forgive the whole world.

A letter from Jean Vanier to Donna F. Johnsonjpg

But I was bothered by something. At that time, I had been working for more than a decade in a shelter for abused women. I was skeptical about moving too quickly to forgiveness. For me, forgiveness was part of a process of reconciliation; a two-way street involving responsibility-taking and reparation for harms done; the active making of amends. Rarely had I seen a man take responsibility for hurting a woman. What Id seen was justification and more abuse.

Heres an excerpt from my letter:

Dear M. Vanier, I have a question for you. How are we to be with people who not only deny responsibility for harm done but seem actively engaged in becoming less human, more oppressive towards the victim? I am thinking about the relations between men and women. I have worked for 13 years with battered women, women who are controlled, beaten and sexually abused by their intimate partners. There is no official war declared on women but our world is dominated by patriarchal thought and ways and women are considered less than human in this system. How are women to be in the presence of men who take no responsibility for their abusive, violent, degrading and oppressive behaviour? Men who not only act reprehensibly but turn the tables on their victims, making them out to be the abusive ones, the crazy ones in court? Id be interested in your thoughts.

Vanier wrote back from Trosly-Breuil in his microscopic handwriting.

Dear Donna, Love to you. Thank you for your letter. Not easy to answer It is the same question as for these men killing people in Kosovo. They are convinced they are right, the other, evil. The Nazis in the concentration camps. These people are closed up behind cement walls protecting their vulnerability, unable to admit their guilt. How can we work with these walls, help break them down. It is easier if they fall sick, have a serious accident. Sometimes the child in them rises up. If they commit a recognized crime and are put in jail where they can find a good therapist. If I were you, I would work out this question with prison psychologists they might have some answers. The difficulty is that we are all frightened of being seen as bad, guilty so we accuse the other. It is their fault. This is what we call projection. Sorry not to be clear, not to have clear answers. Your question is a vital one but I suppose I must begin by accepting that in some ways, in some situations I am guilty I need to admit it. To seek forgiveness. Tell me your ideas Peace to you. Love Jean

It was a thoughtful answer, but it sidestepped the fundamental issue Id raised of mens violence against women. Vaniers lens was psycho-spiritual. He seemed to have no notion of power or systems of oppression.

A few years later, I heard him in person at Notre-Dame Cathedral in Ottawa. Again he spoke eloquently to the deepest longings of the human heart. Vaniers work on the inclusion of outsiders, people marginalized by virtue of disability or difference, is outstanding. But like most thoughtful men, he neglects to consider women. I wrote to him again, asking him why he does not talk about the oppression of women and why he does not use his considerable power and influence to call out mens abuse of women.

Vanier responded.

My dear Donna,

You are quite right. I should talk more of the oppression of women, I have been wondering why I do not mention it more. I have no easy explanation except in my community here in Trosly there is a beautiful harmony amongst us all. There can also be some masculine blindness in me. Thank you for this. Thank you for asking the question. I liked your reflection about masculine sexuality and feminine sexuality I have still work to do. Peace, love to you. Jean

Spiritual leaders, most of whom are men, talk endlessly about peace and love. The more progressive among them may even speak about social justice and human rights. The problem is that their thinking and practice does not include women in any meaningful way. Their human rights do not extend to women.

Another letter from Jean Vanier to Donna F. Johnson.jpg

Is there a religious leader on Earth calling out mens abuse of womens bodies for their own pleasure and power? It is no accident that they are silent on this. Like 19th-century slave-holders, some men are safeguarding a way of life. They want power over women. They need women to hate ourselves in order to ensure our silence and cooperation.

A great moral leader like Jean Vanier could have made a massive difference for the worlds women through the simple act of calling out men on their misogyny. Alas, he too was invested in the power structure. Vanier colluded with other men through his silence, his actions and his denial.

This weekend, the last vestige of hope that good men will stand up for women was shattered. Masculine blindness is killing women. It is a reality that must be confronted. Let us not move too quickly to forgiveness.

Donna F. Johnson worked in an Ontario shelter for battered women from 1986 to 2002. She remains active in the struggle to end violence against women.

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March Declared as Workplace Eye Wellness Month by Prevent Blindness – InvisionMag

March 1st, 2020 9:42 am

(PRESS RELEASE) Prevent Blindness,the nations oldest eye health and safety nonprofit organization, has declared March as Workplace Eye Wellness Month. According to the Centers for Disease Control and Prevention (CDC), approximately 2000 U.S. workers sustain a job-related eye injury that requires medical treatment a day. About one third of the injuries are treated in hospital emergency departments, and more than 100 of these injuries result in one or more days away from work.

For those who work outside an office setting, Prevent Blindness warns of common causes for eye injuries and urges everyone to wear the proper eye protection for risks that include:

The type of safety eye protection that Prevent Blindness recommends depends on the hazards in the workplace. For areas that have particles, flying objects, or dust, safety glasses with side protection (side shields) should be worn. Goggles should be worn for anyone working with chemicals. And, for those working near hazardous radiation (welding, lasers, or fiber optics) special-purpose safety glasses, goggles, face shields, or helmets designed for that task should be worn.

Those who work within an office setting (working with computers and other digital devices) are at higher risk for digital eye strain. According to the American Academy of Ophthalmology (AAO), eye strain symptoms include dry eyes, blurry vision, tearing or watery eyes, and headache. The cause of digital eye strain is that people blink less when they stare at digital devices. The AAO adds that normally, humans blink around 15 times per minutebut this blink rate can be cut in half when staring at screens or doing other near work activities (like reading).

Prevent Blindness recommends placing a digital screen 20 to 26 inches away from the eyes and slightly below eye level. Also, adjust lighting to lower glare and harsh reflections. More tips may be found at here.

Recognizing your eye health and safety needs within the workplace, and taking all the necessary steps to protect vision, can help us all to continue to protect healthy eyesight for years to come, said Jeff Todd, president and CEO of Prevent Blindness.

For more information about workplace eye health topics, please call Prevent Blindness at (800) 331-2020 or visit here.

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Living with visual impairment is a growing issue as baby boomers age – The Denver Channel

March 1st, 2020 9:42 am

WINNETKA, Ill. Nearly 27 million American adults have low vision or blindness. As baby boomers age, experts expect a major one in three will experience vision loss, a condition linked to depression. Its a tough transition leaving many in despair.

In recent years, Illinois resident Richard Englunds vision began fading.

It's a whole new world. You know that you're dealing with something you've never dealt with before, said Englund.

Diagnosed with macular degeneration at 47, the world he knew lost focus. He is now legally blind.

The worst thing that you've finally come to terms with is you can't drive anymore, said Englund.

For Angie, a retired nurse, a third failed corneal transplant meant losing her sight but not her sense of humor.

Not being able to see faces. I mean right now all you guys look like Brad Pitt, said Angie.

But it took time for her to come to terms with it.

I felt like I was walking dead, said Angie. Somebody hit me in the stomach and it just was wrong.

Loss of mobility and independence is difficult and statistically, people with visual impairment or blindness have a 200 percent increase in the risk of clinical depression.

As baby boomers age, the number of Americans with low vision is expected to skyrocket from 2.9 million in 2010 to 5 million in 2030.

The key, say public health officials, is to reach out for help early.

For the last century, Hadley, a non-profit organization has assisted with the scary transition of losing sight.

We basically teach people how to continue to live their lives, said Julie Tye, Hadleys executive director.

Hadley is providing online resources, support and in-person consultation. All of it is free of cost.

Maybe it's something as simple as contrast, maybe it's something as simple as using their smartphone to magnify what they're reading, said Tye.

Englund says relearning independence is tough at any age, but not impossible.

I am not going to let the fact that I can't see keep me from doing anything. I can do anything as long as I put my mind to it, he said.

Angie insists its just another phase of life.

You realize that you go on, you know, it's another journey you're on. You're going to do better, because you have to.

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PROFILE 2020 – Mission to Serve: Ironton Lions Club has been serving community for nearly a century – The Tribune – Ironton Tribune

March 1st, 2020 9:42 am

The Ironton Lions Club was organized by Fred T. Davis, receiving its charter on Dec. 19, 1923.

The Ironton Lions Club was the 18th club chartered in the State of Ohio, and its first president was Howard E. Unrue. The Ironton club now consists of 30 members and the club motto is WE SERVE.

Over the years, the Ironton Lions Club has raised funds through various activities such as a minstrel show, war bond drives, a beauty pageant, haunted houses, haunted tunnel, golf tournaments and the sale of light bulbs and other items.

The funds raised by these efforts were used to support the Lions contributions to the local community, as well as the Lions activities at the district, state and international levels. The Ironton Lions Club annually distributes approximately $10,000 in aid and charity.

Locally, the Ironton Lions have provided monetary support to the Ironton City Mission, the Briggs Lawrence County Library Vision Impaired Center, Open Door School, scholarships, Project LifeSaver, local food banks, Pilot Dogs of Ohio, Ironton Little League, annual Halloween, Christmas and Memorial Day parades, Community Hospice, eye tests and funding for childrens eyeglasses and other worthwhile projects.

The Ironton Lions Club is active in a wide range of blindness and diabetes prevention endeavors at the local, state and international levels.

The Ironton Lions Club also supports The Lions Quest Program, in partnership with the Symmes Valley Multi-Level School, to teach age appropriate positive youth civic development programs.

STORY, BRENT PYLES | PHOTOS, HEATH HARRISON, SUBMITTED

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Eminent Ophthalmologist VK Raju honored by Egyptian Ophthalmology Society – The Indian Panorama

March 1st, 2020 9:42 am

Founder-President of Eye Foundation of America Dr. VK Raju was honored by the Egyptian Ophthalmology Society with a medal for his contribution in the field of prevention of blindness among children worldwide

CAIRO (TIP): Dr. VK Raju, an eminent ophthalmologist based in Morgan Town, West Virginia, USA was invited to Cairo by the Egyptian Ophthalmology Society to speak on childhood blindness. He lectured on difficult cataract surgery, prevention of blindness in premature children. The condition is called ROP (retinopathy of prematurity). If premature babies are given too much oxygen, it can be harmful. It leads to bleeding in the eye and causes permanent blindness. The good news is it can be prevented by laser treatment. Early recognition is the key.

Dr. Raju who is Founder and President of the Eye Foundation of America is a passionate crusader for prevention of avoidable childhood blindness. His passion takes him to many parts of the world, particularly to his country of origin India where he has set up a hospital and eye institute in Rajahmundry, Andhra Pradesh. At the Goutami Eye Institute, Rajahmundry, a dedicated staff serves a large community, particularly rural.

Dr. VK Raju is internationally recognized and has been honored by many organizations. Only this January, Rotary Club of Calcutta, the oldest Rotary club, at their centenary celebrations, honored Dr. Raju for his tremendous contribution.

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Gene therapy shows promise in tackling common cause of childhood blindness – Mirage News

March 1st, 2020 9:42 am

The results of a first-in-human clinical trial of gene therapy to treat a common cause of genetic blindness have shown partial reversal of sight loss in some patients.

X-linked retinitis pigmentosa, caused by mutations in RPGR gene, is the most common cause of blindness in young people. The inherited mutations lead to degeneration of light sensitive cells (photoreceptors) beginning in early childhood leading to severe sight loss.

Until now there has been no treatment for this disease. Gene therapy using viral vectors to deliver a healthy copy of a mutated gene into affected cells aims to slow down the degeneration and preserve visual function.

However, the RPGR gene has an unusual genetic code which makes it unstable to work with in the laboratory and until now difficult to translate into human trials.

Scientists at the University of Oxford reprogrammed the genetic code of the RPGR gene to make it more stable, providing the basis for this first-in-human retinal gene therapy.

The international trial, led by Professor Robert MacLaren, was sponsored by Biogen Inc., with support from the NIHR Oxford Biomedical Research Centre.

Eighteen patients in total were treated with increasing doses of the vector carrying an RPGR gene in which the DNA had been altered, but in a manner that still allowed correct production of the missing protein.

Other trial sites included the Manchester Royal Eye Infirmary and the Bascom Palmer Eye Institute in Miami.

The research teams findings are published in the journal Nature Medicine.

Professor MacLaren, Consultant Ophthalmologist at the Oxford Eye Hospital, commented: We are delighted with the early results of this clinical trial for a degenerative eye disease. It is becoming more apparent to us that novel genetic therapies, when working, lead to a clear improvement in neuronal function, which holds great hope for a variety of other degenerative conditions that have a genetic basis.

Once again, we should take note that this highly successful international gene therapy clinical trial originated in the NHS by applying science that was previously developed in a project funded in the UK by the Medical Research Council.

The early results from the study showed that the treatment was safe and six patients who received mid doses of the vector had unexpected improvements in their peripheral vision beginning as early as one month after the treatment.

One of Professor MacLarens patients, Kurtis Lonie, said: When my mum spotted the trial in an RNIB newsletter I felt so hopeful about what I was reading. At this stage in my life I was struggling deeply with what I thought my life would become. The speed of my conditions degeneration was unknown so I had no choice but to apply and do whatever I could to hopefully help others in the future, as well as myself.

After undergoing tests and screening, Kurtis was given the choice of which eye he wanted to be treated, and he opted for the one with worse vision.

About a month after the treatment my vision was beginning to return in the treated eye. The sharpness and depth of colours I was slowly beginning to see were so clear and attractive. My visual field exploded and I could see so much more at once than ever before in that eye. Before long, the eye was undoubtedly better than the untreated eye.

The results have been nothing short of astonishing and life changing for me, I really hope this trial is approved and they can treat what once was my better eye.

This improvement in peripheral vision experienced by some patients is believed to relate to regeneration of outer retinal structures following successful gene therapy and has implications for the development of similar gene-based treatments for many other retinal degenerations.

Nightstar Therapeutics was a University of Oxford spinout company founded in 2014 and listed on NASDAQ in 2017. The RPGR gene therapy developed in Oxford was licenced to Nightstar in order to set up the international clinical trial.

In 2018 Nightstar Therapeutics was acquired by the large US biotech company Biogen, in what was one of the biggest buyouts of a British biotechnology company to date.

The funding raised combined with the successful start of the clinical trial has highlighted the huge potential for academic collaborations between UK universities, the Department of Health and the global biotechnology sector. This has been a key long term strategic aim of the NHS funding directed through the National Institute for Health care Research (NIHR).

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Katsina Has 25,000 Blind Persons, Says Foundation – THISDAY Newspapers

March 1st, 2020 9:42 am

By Francis Sardauna

A United Arab Emirates (UAE) based non-governmental organiSation, Noor Dubai Foundation on Friday revealed that Katsina State has 25,000 blind persons with only four ophthalmologists spearheading its eye care centre.

Pained by the menace, the charitable organisation in collaboration with the state government, said it had inaugurated a four-year integrated and sustainable eye care programme to improve quality of life and socioeconomic status of the affected persons.

The representative of the foundation, Dr. Rabiu Mansour, who disclosed this to journalists in Katsina while speaking on the achievements of the programme, said six million Katsina citizens were expected to benefit from the programme within the period under review.

He explained that the foundation, which commenced the programme in October 2019, had so far conducted 1,039 successful cataract surgeries and eye screening for 5,238 patients in Katsina, Daura and Funtua general hospitals within four months.

He reiterated that 2,313 visually impaired persons had been treated with either medications or eye glasses, six ophthalmologists and optometrists and one optician had been employed to boost efficient service delivery.

Katsina state has over 25,000 blind people and another 100,000 people with some visual loss, but there are only four ophthalmologists to cater for this population. Currently only about 10 to15 per cent of eye care services are being covered in the state.

In line with Noor Dubai Foundations new strategic plan, it set up a four- year (2019-2023) integrated and sustainable comprehensive eye care programme in partnership with Katsina state government. In addition, a Nigerian office of the Noor Dubai Foundation have been set up in Katsina.

The programme is aim at improving quality of life and socioeconomic status of people of the state through improved access to quality eye care. It will cost about $2 million with the Katsina state government contributing additional 20 per cent in kind.

We intend to conduct cataract surgeries for 12,000 people to restore their sights and 37,000 people are to be screened and treated for eye diseases. While 320,000 school children will also undergo eye screening and treatment. And 1,000 people with permanent visual loss will be rehabilitated, he added.

In his remarks, the State Commissioner for Health, Yakubu Nuhu Danji, said about 4,000 visually impaired people were consulted and 2,000 have been treated by the foundation.

While admitting that the state has 25,000 people suffering from blindness, the commissioner said the alliance between state government and the foundation would eradicate the impediment.

He said: As you are all aware, Katsina state has 25,000 people suffering from blindness and right now we only have four ophthalmologists manning the eye centre we have.

Danja said the state government had inaugurated an awareness committee to educate the residents, particularly rural dwellers on the need to patronise the eye care centres to prevent them from impairment.

Meanwhile, the foundation, established by the Vice President, Prime Minister of UAE and the ruler of Dubai, Sheikh Mohammed bin Rashid Al-Maktoum in 2010 focused on prevention of blindness and visual impairment globally.

Over 27 million people in 18 countries across Africa and Asia were said to have benefited from the free treatment and prevention programmes conducted by the Foundation.

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World Rare Disease Day: Are they more common than you think? – Outlook India

March 1st, 2020 9:42 am

World Rare Disease Day: Are they more common than you think?

New Delhi, Feb 29 (IANSlife) World Rare Disease Day is observed every year on the last day of February.

A Rare Disease is also known as Orphan Disease and is said to affect a small percentage of the population. It presents a countless number of challenges for patients and their family members, including the time it takes to obtain a correct diagnosis.

Although cancer and heart disease get plenty of media attention, the impact and reach of rare diseases vary significantly. One of the rare diseases may affect only a handful of patients, while another disease could affect many. At times, Rare Diseases are difficult to diagnose because of its nonspecific symptoms and because they''re so unusual.

It is said that 1 in 20 Indians is affected by a Rare Disease. According to Indian Society for Clinical Research (ISCR). 70 million in India and 350 million people around the world suffer from rare diseases.

There are more than 7,000 distinct types of Rare and Genetic diseases and it has impacted more people than Cancer and AIDS combined and most of which are progressive, life-threatening, and chronically debilitating conditions and 80 percent of these rare diseases have a genetic origin.

Dr. Mayuri.K.S., Consultant Microbiologist and Infection Control Officer, SPARSH Hospital, Bengaluru shares few types of rare diseases:

Acanthamoeba keratitis

Acanthamoeba keratitis is a vision-threatening rare disease which causes parasitic infection and can be seen most often in contact lens wearers. It is found ubiquitously in soil and water and can cause infections of the skin, eyes, and central nervous system.

This infection of the cornea is difficult to treat with conventional medications. It may lead to permanent visual impairment and blindness in some cases because of damage to the clear portion of the front of the eye called the cornea or through damage to other structures important to one''s vision.

Creutzfeldt-Jakob disease (CJD)

Creutzfeldt-Jakob disease is also known as Classic Creutzfeldt-Jakob disease. CJD is a fatal degenerative brain disorder which is believed to be caused by a protein known as prions. The early symptoms include visual disturbances, memory problems, behavioural changes and also poor coordination.

The later symptoms include weakness, involuntary movements, blindness, dementia and coma. About 70 percent of people die within a year of diagnosis as there is no specific treatment for CJD.

Cysticercosis

Cysticercosis is a rare infectious disease. It is a tissue infection which is caused by the tapeworm present in the pork. It is known to cause neurocysticercosis which affects the brain and can cause neurological symptoms. Individuals suffering from this rare disease may have few or no symptoms for years.

Cysticercosis is usually acquired by eating contaminated food. One of the major sources is said to be uncooked vegetables. Drinking water contaminated by tapeworm eggs from human feces is also one of the main reasons to cause the infection.

Mucormycosis

Mucormycosis is caused by fungi in the order Mucorales. And they are generally the species in the Mucor, Rhizopus, Absidia and Cunninghamella. The disease is often characterized by hyphae growing in and around blood vessels and can be potentially life-threatening in diabetic or severely immune-compromised individuals.

Mucormycosis and zygomycosis are sometimes used interchangeably. It frequently infects the sinuses and the brain. While infection of the oral cavity or brain is the most common form of mucormycosis and it enters the body through a cut in the skin. The fungus can also infect other body areas such as the gastrointestinal tract, other organ systems and in rare cases, the maxilla may be affected by mucormycosis.

Fungal infections are usually prevented by the rich blood vessel supply of maxillofacial areas. Although more virulent fungi responsible for mucormycosis can often overcome this difficulty.

Naegleriasis

It is also known as PAM - Primary Amoebic Meningoencephalitis. This rare disease is an almost invariably fatal infection of the brain by the free-living unicellular eukaryote Naegleria fowleri. Symptoms are meningitis which includes headache, fever, nausea, vomiting, a stiff neck, confusion, hallucinations and seizures. Symptoms progress rapidly over five days and death usually results within one-to-two weeks of symptoms.

Nocardiosis

Nocardiosis is an infectious disease affecting either systemic nocardiosis which is the whole body or pulmonary nocardiosis which are the human lungs. It is caused due to an infection by a bacterium of the genus Nocardia, most commonly Nocardia asteroides or Nocardia brasiliensis. It is most commonly seen in adult males, especially those with a weak immune system.

Patients with brain Nocardia infection, mortality exceeds 80%, in other forms, mortality is 50%, even with appropriate therapy. It is one of several conditions that have been called "the great imitator" and Cutaneous nocardiosis commonly occurs in immunocompetent hosts.

Rat-bite fever

It is an acute, febrile human illness caused by bacteria transmitted by rodents, in most cases, which is passed from rodent to humans by the rodent''s urine or mucous secretions. Alternative names for this rare disease include streptobacillary fever, streptobacillosis, spirillary fever, bogger, and epidemic arthritic erythema. It is spread by infected rodents and can be caused by two specific types of bacteria.

In some of the cases are patients were diagnosed after they were exposed to the urine or bodily secretions of an infected animal. These secretions can come from the various body parts like mouth, nose or eyes of the rodent and majority of cases are due to the animal''s bite. It is also said to be transmitted through food or water contaminated with rat feces or urine.

Other animals that can be infected with this disease are household pets, weasels, gerbils and squirrels. It is important to quickly wash and cleanse the wound area thoroughly with an antiseptic solution to reduce the risk if a person is bitten by a rodent.

Cat-scratch disease (CSD)

It is caused due to scratching or biting of a cat. Typically include a non-painful bump or blister at the site of injury caused due to scratch or bite. Within 3-14 days following infection and the individual may feel tired, have a fever and headache.

Cat scratch disease is caused by the bacterium Bartonella henselae spread by the cat''s saliva. Young cats pose a greater risk than older cats. Diagnosis is generally based on symptoms but confirmed through blood tests.

The primary treatment is supportive. Recovery occurs within four months but can require a year. About 1 in 10,000 people are affected and it is found to be more common in children. These diseases may seem to be rare, but there is a significant figure that highlights just how many people are living with it but that gets a little attention due to their singularity. The challenges they face are common to millions of people across the world.

There is much work to be done to spread the awareness of rare diseases and also to improve the diagnosis and treatment of rare diseases. Only less than 5 percent of the 7000 rare diseases have approved therapies. On average, the rare disease patient waits about five years from symptom onset to accurate diagnosis.

In order to tackle the challenges that people living with a rare disease and their families face every day, awareness campaigns should focus on bridging all the gaps in the coordination between medical, social and support services.

--IANS

lh/adr/sj/

Disclaimer :- This story has not been edited by Outlook staff and is auto-generated from news agency feeds. Source: IANS

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Cynthia Taylor: Speaker will address the question Can we all get along? – The Augusta Chronicle

March 1st, 2020 9:42 am

A mutually hurting stalemate. That seems to be a good description of where we are as a country and its tearing at our souls. This doesnt just apply to our political divisions, which seem insurmountable, but also to the racial divide in our country.

Nearly 30 years ago, riots broke out in Los Angeles over the acquittal of police officers who had been accused of savagely beating Rodney King. At the height of the riots, an anguished King appeared on television asking the haunting question, Can we all get along? That question is written on his gravestone.

Apparently, the answer seems to be, No, we cant get along. Or can we?

The Rev. Gary Mason, a Methodist minister from Northern Ireland, has spent his life working on how to answer the question, Can we all get along? The divisions in that country were as deep or deeper than anything were currently experiencing in America. And yet, Mason was one of those who became involved in the peace process in Northern Ireland that has led to reconciliation. He was recognized by Queen Elizabeth for his work in the peace process.

At the Last Supper, Jesus prayed that we all may be one. But becoming one doesnt mean its easy nor does it mean we all end up thinking alike. Like those in Northern Ireland, we dont know how to put down our weapons. Here our weapons are words and actions that demonize others, making them seem less than children of God, made in the image of God.

Such violence has led to what Mason calls the mutually hurting stalemate. Those of us who follow Jesus call him the Prince of Peace, but we dont always live into being peacemakers ourselves. We dont know how to disagree well without being disagreeable. We dont know how to have the hard conversations with those who differ from ourselves.

We have just begun the season of Lent and, in my tradition, it began this past week with Ash Wednesday a service of repentance and reconciliation with God and others.

In part of the service called The Litany of Penitence, we ask God to accept our repentance for the wrongs we have done; for our blindness to human need and suffering for all false judgments and for our prejudice and contempt toward those who differ from us.

True repentance is not just acknowledging all the ways we have fallen short but living into a new way of being, a new way of life.

Gary Masons life work is teaching how to live into a new way of being and doing the hard, hard work of reconciliation. Its not wrapping ourselves in a cocoon of naivety that peacemaking is easy. Its not. But, sweet Lord, is it ever necessary, now more than ever.

Mason will be in Augusta for a series of events on Reconciliation: Healing the Hurt. These will be held at Church of the Holy Comforter, 473 Furys Ferry Road, Martinez. The first is a Community Forum on Saturday, March 7 from 6-8 p.m. Then he will be teaching and preaching Sunday, March 8, beginning at 9:15 a.m. in the Rectors Forum and worship at 10:30 a.m. All events are free and open to the public.

After his work in Northern Ireland, Mason started Rethinking Conflict, an institute devoted to social justice, conflict transformation, peace building and addressing religious fundamentalism. He is an adjunct professor at Candler School of Theology and the Kennedy Institute for Conflict Intervention in Maynooth University, Ireland.

Can we all get along? How will you answer that question?

The Rev. Cynthia Taylor is the pastor of the Church of the Holy Comforter in Martinez.

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Microsoft Invests In A New AI For Health Initiative – Forbes

March 1st, 2020 9:42 am

As one of the richest people in the world, Bill Gates is known for contributing to global health through the Gates Foundation. As his biggest legacy, Microsoft is also moving in the same direction. The company is actively involved in helping the worlds population overcome some of the most challenging health problems and concerns.

Microsoft recently announced a new healthcare initiative known as AI for Health, a program worth over 40 million dollars. AI for Health evolved out of the AI for Good Program, which offers general aid to the less fortunate around the world.

The new initiative will primarily focus on health-related problems and the integration of AI and tech solutions. The main goal behind AI for Health is to directly research the impact of AI in the medical field, as well as develop algorithms for automatic detection of diseases and other medical operations. Besides building new solutions, the program will also work toward making these technologies more available worldwide.

AI for Health is a philanthropic initiative that complements our broader work in Microsoft Healthcare. We will support specific nonprofits and academic collaboration with Microsofts leading data scientists, access to best-in-class AI tools and cloud computing, and select cash grants, wrote Microsofts John Kahan in the official announcement of the new initiative.

How AI Can Aid the Healthcare Industry

Even to this day, underdeveloped countries are very far from being able to afford and implement AI technology in medical treatments. There is no doubt that modern healthcare solutions are distributed unevenly, leaving the population of some countries to die of diseases that dont even exist in modern countries anymore.

Even though AI cannot directly aid in distributing healthcare evenly, research in this field can help provide more affordable solutions. For example, AI can be used to build reliable screening systems for disease detection, more specifically for diabetic retinopathy which leads to blindness if not treated in time. AI-based systems would serve as cheaper and easier diagnostic processes for patients around the world.

Microsofts program aims to encourage the best experts in the field to actively help engineer and deploy such solutions. There is no doubt that the companys monetary investment is going to help push this project to the right direction. The company has already made several important partnerships with parties that can benefit from this research.

The AI-oriented research will look for solutions for various diseases and issues including tuberculosis, maternal mortality, and even cancer. It is also important to mention that Microsoft has decided that the new initiative wont be open for public organizations. Instead, it will be working directly with the privately chosen non profits and research organizations.

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3 High-Risk, High-Reward Stocks That Have Massive Upside Potential – The Motley Fool

March 1st, 2020 9:42 am

There are a lot of promising stocks out there for investors to choose from. However, if you're looking for companies with the most growth potential, the world of small-cap stocks is one of the best places to look.

In particular, biotech stocks are very well known for having tremendous upside potential. New drug candidates can easily bring in billions in revenue for companies, should they prove to be a success. However, many of these stocks are quite risky investments, especially since a good number are barely reporting any revenue figures whatsoever.

If you're comfortable with these types of investments, here are three high-risk, high-reward stocks that you should keep your eye out for in the future.

Image source: Getty Images.

Gene editing is an incredibly promising market that many biotech investors are paying close attention to. There are plenty of genetic disorders out there that might not be treatable with today's technology, but could be cured with the use of gene editing treatments in the future. Editas Medicine (NASDAQ:EDIT) is one company in this space that boasts a number of promising drug candidates, and it also has an impressive patent portfolio.

Editas's flagship drug candidate is EDIT-101, a treatment for a rare form of blindness in children called leber congenital amaurosis (LCA), which leads to a loss of eyesight as the retina fails to function properly. Although LCA is rare, affecting only 2 to 3 newborns per 100,000, the good news for Editas is that not many companies out there are trying to treat this condition.

Currently, the only other treatment for LCA is Luxturna, a drug developed by Spark Therapeutics. Besides the massive $850,000 price tag (or $425,000 for just one eye), Luxturna only works for a very specific variant of LCA, with most of the patient population not qualifying for the treatment.

EDIT-101, on the other hand, would be available for all LCA patients. Assuming EDIT-101 is priced somewhere near Luxturna's price point, the company would need to treat just 1,300 LCA patients annually for EDIT-101 to make over $1 billion in revenue. Considering that Editas made only $3.8 million in its recent third-quarter 2019 results, it's easy to see how positive results from this one drug alone could catapult the company's stock to new highs.

EDIT-101 is currently undergoing early clinical trials and likely won't be available for a couple of years at the earliest, if not longer. There is one other small-cap biotech stock,ProQR Therapeutics, working on a possible LCA treatment,but it's doing so without any backing from other, larger pharmaceutical giants.

In comparison, Editas has partnered with Allerganto help commercialize EDIT-101 should it become a success. Having a big partner such as Allergan with strong connections in the industry is a big advantage for any small-cap biotech stock looking to market its candidates.

Back in early January, I argued that Puma Biotechnology (NASDAQ:PBYI) was far from a good investment. By the end of 2019, the stock had lost around95% of its market capin comparison to where it was just a couple years before. Coupled with uncertainties regarding the appeal of its main drug, Puma's future looked very uncertain.

However, the stock has seen a surprising comeback over the past couple of months, surging by about 22%. The weird thing is that there's not much in the way of news to justify this rise. Puma's recent fourth-quarter results were pretty bad, with revenue down 11.5% to $62.9 million from last year, although this still slightly beat out analyst expectations.

Image source: Getty Images.

Puma's main treatment is its cancer drug Nerlynx, which is given to adults who have early stage HER2-positive breast cancer (a form of the disease that tests positive for a protein called human epidermal growth factor receptor 2, or HER2, which promotes the growth of cancer cells). The problem is that Nerlynx causes severe diarrhea as a side effect, which has led to a startlingly high discontinuation rate among patients.

While the company is making efforts to tackle this problem, such as providing vouchers for anti-diarrheal medications, it's still uncertain whether Nerlynx sales will recover.

The silver lining behind all this is that Puma is incredibly cheap, with the stock currently trading at a measly 1.9 price-to-sales ratio. While I don't think there's much hope for Nerlynx as a blockbuster cancer drug, there's a solid chance that Puma could become a buyout target for another, larger biotech company, considering how cheap its stock is. Should this happen, shareholders would see a significant surge in Puma's stock price following the news.

If you want to buy in anticipation of this, however, it might be best to wait for the stock to dip back down in value again. Considering that this recent surge doesn't seem backed by anything substantial in terms of news or catalysts, it wouldn't be surprising for the stock to tumble down once more. Long-term, however, Puma has a good shot at becoming an acquisition target, and as such, has a fair bit of upside potential in 2020.

Xenon Pharmaceuticals (NASDAQ:XENE) is a small-cap biotech stock that, by the end of the year, could easily have three late-stage drug candidates in its pipeline.

Its flagship drug, XEN496, is one of Xenon's promising epilepsy treatments, and is on the cusp of entering phase 3 trials.

XEN1101 is another epilepsy candidate that's currently in phase 2 trials, while XEN007 is a candidate also in phase 2 trials and is meant as a treatment for orphan neurological indications, which includes symptoms such as migraines, vertigo, and certain types of epilepsy.

Xenon has also grabbed the attention of a number of pharmaceutical giants interested in its drug candidates. Merckand Rocheare the two standouts, while Flexion Therapeuticsand Neurocrine Bioscienceshave also signed strategic partnerships with Xenon.

These agreements have helped finance Xenon's clinical development, with the company receiving $50 million in cash and equity from Neurocrine back in December.

Another one of Xenon's epilepsy drug candidates, XEN901, is eligible for up to $1.7 billion in milestone payments from Neurocrine, should the drug prove to be a success. In comparison, Xenon reported just $3.5 million in third-quarter revenue.

With that much potential upside from just one of Xenon's epilepsy candidates, the optimism surrounding this specific biotech stock is justifiably high.

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3 High-Risk, High-Reward Stocks That Have Massive Upside Potential - The Motley Fool

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Makers of adulterated wine ask customers to check their bottles – The Brussels Times

March 1st, 2020 9:42 am

Photo from Antwerp prosecutor's office

The Dutch makers of the wine branded Black & Bianco have called on anyone who bought the wine to check the bottle to see if it has been tampered with.

Earlier in the week it was announced that a Belgian woman from Puurs in Antwerp province had died after drinking a small amount of the wine. At autopsy it was found that the wine had been adulterated with large doses of MDMA or ecstasy and a similar illicit drug MDA.

The bottle she drank from did not have the brands trademark black cork covered with a black foil bearing the companys name and logo. Police hypothesised the bottle was one of several adulterated as a method of smuggling the rugs into Belgium illicitly.

However no new cases have come to light, despite the fact that the victim died in December, and the news this week was widely covered.

In addition, it is not clear how the bottle could have escaped the hands of the smugglers themselves, and finished with a legitimate client in Belgium.

The wine Black & Bianco RED Merlot Cabernet Sauvignon is not sold in Belgium other than online, although it is on open sale in the Netherlands.

Meanwhile a number of the webshops that had previously carried the wine in question have withdrawn it from sale, while the brand owner said the wine is absolutely still drinkable so long as the cork has not been tampered with.

The telephone here doesnt stop ringing. Many of our clients are naturally asking questions. They want to know whats going on, and if there are possibly other bottles that are not right, said owner Coen Scholders.

I can understand their concern, but our wine can absolutely still be drunk. There is for the time being no indication that more of our bottles have been tampered with and are still in circulation.

Meanwhile it has been revealed that the woman who died was an employee of Finshop, a shop operated by the federal finance ministry which sells off goods seized by customs officers to the general public. Three years ago some customers had to be rushed to hospital after a bottle of wine on sale in one of the shops turned out to contain MDMA in methanol a dangerous form of alcohol that can cause blindness and death.

Since then, however, Finshop stores no longer sell wine to members of the public, the ministry said.

Ministry spokesperson Francis Adyns said it was unlikely the woman had come across the wine in the shop and taken it home. The Antwerp prosecutors office said it had no information to suggest that might have happened, but that all avenues of investigation are being looked at.

Alan HopeThe Brussels Times

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Frank Buckles, the last soldier to fight in World War I dies at 110 – SOFREP

March 1st, 2020 9:41 am

Frank Buckles lived an amazing and long life.

He joined the Army at only 16 years old to fight in World War I, and later as a civilian, working in the Philippines, was captured by the Japanese at the outset of World War II. He survived three hellish years as a POW at Los Banos POW Camp before being rescued in a raid by American forces.He passed away on February 27, 2011, at the age of 110.

Buckles was born on Feb. 1, 1901, in Bethany Missouri. He was the youngest of five children and the third boy in the household. His familys ancestry traced back to the Revolutionary and Civil Wars. One thing that stood out, however, was that his family genetics were blessed with longevity. As a young boy, he remembered long talks with his grandfather who was born in 1817. His father lived to be 95, his grandmother 96. When he was young he had two aunts that told him to prepare himself for a long life. Both of them lived to be over 100.

When he just a teenager, his family moved from Missouri to Oakwood, Oklahoma, where Buckles went to school, worked in a bank and became an avid wireless operator. With the United States entering World War I, although he was just 16 years old, he tried to enlist. The war, which had started in 1914, was an important event, he remembered later. The world was interested in it. So, I was interested. The Marine Corps turned him down as being too small, sensing that he was underage; the Navy also turned him down ostensibly for having flat feet, also believing him to be too young. But the Army did not. An Army captain asked him for a birth certificate. I explained that when I was born in Missouri, birth certificates were not a public record, Buckles said. It would be in the family Bible. And I said, You wouldnt want me to bring the family Bible down here, would you? He said, Go on, well take you.' So, the U.S. Army hurting for manpower accepted the youngster and he joined on August 14, 1917.

Buckles underwent basic training at Ft. Riley, KS. After basic training, he was trained as a motorcycle rider and ambulance driver. Later in 1917, he was among the first Americans who made their way from England to France. He saw first-hand what combat in the trenches did to the men fighting there as he transported them to hospitals in the rear.

There was never a shortage of blown-up bodies that needed to be rushed to the nearest medical care. The British and French troops were in bad shape even guys about my age looked old and tired. After three years of living and dying inside a dirt trench, you know the Brits and French were happy to see us doughboys. Every last one of us Yanks believed wed wrap this thing up in a month or two and head back home before harvest. In other words, we were the typical, cocky Americans no one wants around, until they need help winning a war.

At the wars end, he helped transport thousands of German POWs back to their homeland. One German soldier gifted him with a belt buckle with the inscription Gott mit uns (God with us). It was a gift that he would keep for the rest of his life. Promoted to Corporal just before he was mustered out in November 1919, Buckles returned to the United States and took part in the dedication of the Liberty Memorial in Kansas City, Missouri where he met the Commander of the American Expeditionary Force General John Pershing.

After the war, despite many veterans having trouble finding work, Buckles never was at a loss for one. He worked in NYC, Toronto, then took a job as a ships purser, and later he ran the Manila office of the American President Lines when the Japanese invaded the Philippines in December 1941 after the bombing of Pearl Harbor. He and many other Americans, both civilian and military, were taken as prisoners of war.

Buckles was a POW for more than three years in the Santo Tomas and Los Baos prison camps. When I got down to 100 pounds, I quit looking at the scales, he said. Like many POWs, he contracted beriberi, a disease caused by malnutrition. To combat the disease, he led a daily calisthenics class for the POWs. I explained to them, he recalled, that were under severe circumstances, but you must keep yourself in shape for when the war is over.

On February 23, 1945, they were all liberated in a daring raid led by the Armys 11th Airborne Division and Filipino guerillas. All 250 of the Japanese guards were killed and the combined rescue force liberated 2147 POWs. Buckles had completed his second war and was now 44 years old.

After the war, he returned to the United States and married Audrey Mayo in 1946. The two bought a 330-acre cattle ranch in West Virginia. They raised a daughter, Susanah, and remained in WV. His wife died in 1999. He continued to drive the tractor on his farmland well into his 100s.

Gary Sinise and Buckles led the Memorial Day Parade of 2007; he was 106 at the time. He was later asked to visit the White House as a guest of President George Bush. Buckles thought that it was an interesting visit. I went to the White House and sat in the Oval Room, he recalled. And here came President Bush and he asked me: Where were you born? And I said, Thats exactly the words that General Pershing used.

Buckles became the honorary Chairman of the World War I Monument Committee and was an outspoken advocate for the dedication of a monument to honor the men who sacrificed so much during the Great War.

We still do not have a national memorial in Washington, D.C. to honor the Americans who sacrificed their lives during World War I. On this eve of Veterans Day, I call upon the American people and the world to help me in asking our elected officials to pass the law for a memorial to World War I in our nations capital. These are difficult times, and we are not asking for anything elaborate. What is fitting and right is a memorial that can take its place among those commemorating the other great conflicts of the past century. On this 92nd anniversary of the armistice, it is time to move forward with honor, gratitude, and resolve.

Buckles died on February 27, 2011, aged 110. He was buried with full military honors in Arlington National Cemetery. As was noted by Paul Duggan, a reporter for the Washington Post:

The hallowed ritual at grave No. 34-581 was not a farewell to one man alone. A reverent crowd of the powerful and the ordinaryPresident Obama and Vice President Biden, laborers and store clerks, heads bowedcame to salute Buckless deceased generation, the vanished millions of soldiers and sailors he came to symbolize in the end.

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Frank Buckles, the last soldier to fight in World War I dies at 110 - SOFREP

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Stories from the street: This group gathers to write, share stories and celebrate milestones – Idaho Press-Tribune

March 1st, 2020 9:41 am

It was an offer I couldn't refuse.

I recently had the opportunity to attend a monthly meeting of a group of Treasure Valley writers who also happened to be celebrating a milestone: one of their members had just turned 100.

I arrived at the home of Peggy Thiessen in Boise. She and two others Lavaughn Wells and Nancy Ives were waiting for "the birthday girl" to arrive. In the meantime, we began talking.

I found out that this group of "women of a certain age" the youngest, I was told, is 68 get together once a month to share their stories. They all have been working on their autobiographies for a number of years. They follow Frank P. Thomas' book, "How to Write the Story of Your Life."

At each meeting, they read their most recent installments out loud to one another. "An interesting thing is when we read our stories we piggy-back on top of each other," said Thiessen. "There are triggers. We'll think of something in our past that we want our children to know."

The stories are for family members to read so that they can get a glimpse of what their mother's, grandmother's, aunt's or great-aunt's lives were like "before smartphones."

It's a chance to show that there may be more than work or looking at screens, said Ives. "I write my stories in the hopes that my great-nieces will not be too orthodox. I think there's a lot more to life than 8-to-5," she said. "I hope this will give them a spark to get away and see some of the world."

Thiessen, 78, the de facto leader and hostess of the group, said she has been through Thomas' book about four times and each time remembers more stories to write down.

"As you write more and more, you remember more and more," she said. "I tend to write about the funny things instead of the harder things I don't want to think about those things."

Theissen writes all of her tales out in longhand, and her husband, Wayne, types them up for her. They've been married for 57 years, but still "sometimes he learns something new or remembers something he forgot," she said.

Wells, 80, traveled around spending time in Indiana, Ohio and Kentucky before lighting down in Boise in 1986. "My husband, David A. Wells, started the Blue Thunder Marching Band at Boise State," she said. "The first time they were on the field was in 1987."

Lavaughn Wells was also involved in music she had been a teacher in choral music at Nampa High.

Ives, 82, was originally from California and came to Boise by way of Taiwan in 2007. "It was a jump," she said, smiling.

Then the guest of honor arrived. Ethel Farnsworth walked into the room, took a seat and looked around, noting everyone there.

"I've had an interesting life," she said.

Farnsworth, who actually turned 100 on Feb. 9 which also happened to be Ives' birthday held her latest story on her lap. "We're so old, we're turning things over to the historical society," she said, laughing.

Prompted by Thiessen, Farnsworth regaled the group with the story of how she and her husband, Ken Farnsworth Jr., now deceased, came to be the owners of Rhodes Bake-N-Serv, the frozen bread dough company.

There was a Mr. Rhodes, she said, and through a series of fortunate events, he came up with the winning formula for frozen bread dough, much to the delight of homemakers everywhere.

"Mr. Rhodes had found this recipe in the drawer of a cabinet," said Ethel. He handed the it over to his ingenious nephews who began perfecting the process.

Ethel's husband, Ken, who had started a food brokerage business, sort of stumbled onto his bread destiny.

He found Rhodes Bread while traveling in northern Idaho, said Ethel. "He saw some women, who he knew were home bakers, waiting at a grocery store for the bread truck to come in." Intrigued, Ken Farnsworth waited, too. When the truck arrived, it wasn't at all what Farnsworth had imagined: it was a small truck with two college-aged young men handing out frozen loaves of bread dough to the excited women who took the dough home and made fresh "homemade" bread.

Not what he thought, no, but Ken Farnsworth was mightily impressed.

"He immediately went to Portland to meet Mr. Rhodes," said Ethel. "In time, Ken convinced (Mr. Rhodes) he could do a good job with Rhodes bread and he added it to his brokerage and he eventually bought the business," she said.

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Ken Farnsworth became the owner but always remained faithful to the bread basics started by Rhodes, who had been a strict vegetarian and humanitarian. "Herbert Cecil Rhodes founded Rhodes Bake-N-Serv in 1958," it says on the company website. "He was a man with high standards and personal principles. ... He did not allow any preservatives to be added to Rhodes White Bread Dough or White Roll Dough. The flour he selected also had to be of the highest quality, unbleached, and have a high-protein content.

Ethel, who was a home economist, published a number of frozen bread dough recipe books for the company, but the most requested recipe through the years is the Butterscotch Bubble Loaf.

Today, the company is run by Kenny Farnsworth, their oldest son. "He's doing such a good job, Rhodes is in all 50 states and he's working on Hawaii," Ethel said.

Looking over her life, Ethel talked about some of the highlights, including her eight children, 16 grandchildren, "and who knows how many great-grandchildren," plus some great-great grandchildren.

After moving from Massachusetts to Morningside Park in Los Angeles, The Farnsworths "found" Boise, she said, in 1959.

"My husband was traveling the 13 western states and he always liked Boise, he found it so friendly," Ethel said. "One day he called and said, 'I bought you a house on Owyhee Street in Boise, Idaho.' I said 'get me a map,'" she said laughing.

She taught foods classes at Boise State University for two years until "they decided (teaching) the classes was too expensive maybe they had to buy a new stove or something," she said, laughing.

She was moved over to The Learning Center in 1976 or '76, she said, where she worked with some of the community's earliest refugee population. "It was the fall of Saigon and people from Vietnam were coming in to Boise. I was in charge of the refugee center," she said.

Farnsworth still goes on walks every day "when the sun shines," works out with her exercise programs on Tuesdays and Thursdays and plays Mahjong twice a month.

To what does she owe her longevity?

She thinks a moment. "I would just say it's just genetics," she said with a smile.

"We're still pretty active old broads."

Know somebody with a story to tell? A neighbor, friend? Someone youve met in school, at church or the grocery store? Send your story ideas to jhuff@idahopress.com, or call 208-465-8106 or 208-871-0911.

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Stories from the street: This group gathers to write, share stories and celebrate milestones - Idaho Press-Tribune

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