StemCell Therapy

Frances Salter caught up with the Goo Goo Dolls ahead of their show at Londons Roundhouse to chat booze, sentiment, and rock n roll welfare.

What do I know? I write sappy love songs, for housewives.

Ive just asked Johnny Rzeznik for his secrets to lasting in the music business, which sappy love songs or no is something he knows a thing or two about. Since their mainstream breakthrough in the early nineties, Goo Goo Dolls record sales have exceeded 12 million albums worldwide, not to mention the four Grammy nominations. Theyre now touring 2019sMiracle Pill,wrapping up the UK leg at Roundhouse a couple of hours after we speak.

When pressed, hes got some quite specific advice. Dont sell your publishing. Do all the drugs and drink as much as you want until youre about twenty-six, and then knock it off. The myth is that booze and drugs make you more creative, but no: they lessen your inhibitions. After a while, instead of being an asset to your work, they become a liability.

Miracle Pillis the latest step on a remarkable journey together for John and Robby, from their early punk-rock days in Buffalo, New York, through to commercial success that has seen their music covered by the likes of Taylor Swift. Nonetheless, theyre keen to emphasise that it was far from an overnight success.

Everyone starts by mimicking other peoples voices, says Johnny. But the trick is to keep after it until one day your own unique voice comes out. Unfortunately, a lot of people just arent given the opportunity to become fully-formed artists anymore. Everything is disposable now, and very few artists are doing anything that will sound good in twenty years. When we were coming up, our record label let us ride along for three albums.

Or, as Robby puts it, We were on rock n roll welfare.

I feel sorry for the new kids coming up because they dont have that trajectory. Now you have to be ten different things: a DJ, a producer, a philanthropist, a marketing expert. No, no. Your job is to sit and perfect your craft. If Stairway to Heaven came out today, it would probably be overlooked unless someone caught Robert Plant on a viral video, or if there was a famous rapper in the middle of it. Its about the things surrounding the art you create, not the thing itself. But maybe Im just saying that because Im old.

So, after so much time in the public eye, what do people not know about Goo Goo Dolls? People have all kinds of assumptions of people that they see on stage. That theyre happy, that theyre rich, that their lives are better than other peoples. Its not true.

The new record, from which theyll play a half-dozen songs that night alongside older material, is a reflection of the Dolls talent for as Johnny terms it brutal sentiment. The titular Miracle Pill, the band have said, is a metaphor for the speedy gratification of the Instagram age, in which we can demand instant elation from chemicals and instant approval from the internet.

By contrast, it may take more than twenty years to build a body of work you can stand behind, but as the Roundhouse crowd will attest, its worth it.

Related

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Miracle Pill: Goo Goo Dolls on Longevity in the Music Business (The VH Interview) - VultureHound Magazine

Longevity and Anti-senescence Therapy

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Latest newfangled report of Longevity and Anti-senescence Therapy Market with outstanding growth by 2025 - News Times

Transaction to Create a Nasdaq-listed Longevity Care Company

AUSTIN, Texas, March 03, 2020 (GLOBE NEWSWIRE) -- Superconductor Technologies Inc. (STI) (SCON), a leader in superconducting innovation, reported it entered into a definitive merger agreement with Allied Integral United, Inc. (Clearday), a privately-held company dedicated to delivering next generation longevity care and wellness services, whereby a wholly-owned subsidiary of STI will merge with and into Clearday in a stock-for-stock transaction with Clearday.

Upon completion of the merger, STI will change its name to Clearday, Inc. The merged company will focus on the development of Cleardays non-residential daily care service model as well as the continued operation of Cleardays existing Memory Care America residential memory care facilities. As part of plans to develop and expand its assortment of innovative, non-residential daily care services, Clearday intends to leverage STIs existing Cryogenic Cooler as an enabling technology for one of its service offerings in the home healthcare market. No financing is required under the Merger Agreement.

Clearday is dedicated to delivering the next generation of longevity care and wellness services for patients with dementia or other cognitive or physical challenges, stated James Walesa, Chief Executive Officer and Chairman of Allied Integral United, Inc. known as Clearday. We have built a network of highly-rated residential memory care facilities in four U.S. states. Now we are developing a disruptive new non-residential daily care service model intended to deliver 75% of the care available in residential environments at 25% of the price. To cost-effectively expand our home healthcare initiatives, we need technology to play a key role. STIs Cryogenic Cooler has over six million hours in operation demonstrating superior reliability and efficiency that we believe will be useful in our growth plan.

Following an assessment of strategic alternatives, our Board of Directors has concluded that a merger with Clearday offers an excellent opportunity to create meaningful value for our stockholders, said Jeff Quiram, STIs President and Chief Executive Officer. As we wind down our Conductus superconducting wire platform, we believe the Clearday transaction has the potential to monetize our cryogenic cooler technology, which was developed as an important part of our overall technology solution.

About the Proposed Merger TransactionOn a pro forma basis and based on the number of shares of STI common stock to be issued in the merger, the pre-merger STI stockholders will own approximately 3.7% of the post-merger combined company and the pre-merger Clearday stockholders will own approximately 96.3% of the post-merger combined company, each on a fully-diluted basis, subject to adjustment as provided in the Merger Agreement which could increase (but not decrease) the percentage owned by STI stockholders. The transaction has been approved by the board of directors of both companies. The merger is expected to close in the second quarter of 2020, subject to the approval of the stockholders of each company, as well as other closing conditions, including, the Joint Proxy and Registration Statement for solicitation of the stockholder approval and issuance of the shares in the merger being declared effective by the U.S. Securities and Exchange Commission, Nasdaqs approval of continued listing of STI common stock under Nasdaq rules, and STI adjusted net working capital being no less than negative $250,000 as of immediately prior to the merger. The Merger Agreement may be terminated by the parties under certain circumstances including, among others, a termination right by STI if certain financial statement deliveries are not timely made by Clearday.

A.G.P./Alliance Global Partners is acting as exclusive financial advisor to Clearday on the proposed transaction.

Management and OrganizationFollowing the merger, James Walesa, Chief Executive Officer and Chairman of Allied Integral United, Inc. known as Clearday will be appointed to serve as the post-merger combined companys chairman, president and chief executive officer. The board of directors for the post-merger combined company will be comprised of five directors, with Clearday nominating four of the five directors, three of who will be independent. Cleardays executive and management team to be appointed as the executive and management team of the combined company. Members of the STI executive team are expected to support the Clearday transition. Jeff Quiram, STIs Chief Executive Officer, is expected to be a director on the board, but is not entering any employment or consulting agreements.

Story continues

About Clearday, Inc.Clearday is an innovative longevity care and wellness company, with a modern, hopeful vision for making high quality care options more accessible, affordable, and empowering for older Americans and those who love them. Through its subsidiary Memory Care America (MCA), it operates a network of highly rated residential memory care communities in four U.S. states. With its Clearday Clubs concept, Clearday will bring the same standard of excellence found in its MCA residential facilities to a daytime-only community model that is dramatically less expensive than residential care options. Clearday Clubs are expected to open in the second quarter of 2020. Learn more about Clearday and Clearday Clubs atmyclearday.com

About Superconductor Technologies Inc. (STI)Superconductor Technologies Inc. is a global leader in superconducting innovation. Since 1987, STI has led innovation in HTS materials, developing more than 100 patents as well as proprietary trade secrets and manufacturing expertise. For more than 20 years STI utilized its unique HTS manufacturing process for solutions to maximize capacity utilization and coverage for Tier 1 telecommunications operators. Headquartered in Austin, TX, Superconductor Technologies Inc.'s common stock is listed on the NASDAQ Capital Market under the ticker symbol SCON. For more information about STI, please visit http://www.suptech.com.

Important Additional Information Will be Filed with the SECIn connection with the proposed transaction between STI and Clearday, the parties intend to file relevant materials with the SEC, including a STI registration statement on Form S-4 that will contain a combined proxy statement/prospectus/information statement. INVESTORS AND STOCKHOLDERS OF STI AND CLEARDAY ARE URGED TO READ THESE MATERIALS CAREFULLY AND IN THEIR ENTIRETY WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION ABOUT CLEARDAY, THE PROPOSED MERGER AND RELATED MATTERS. Investors and shareholders will be able to obtain free copies of the proxy statement/prospectus/information statement and other documents filed by STI with the SEC (when they become available) through the website maintained by the SEC at http://www.sec.gov. In addition, investors and shareholders will be able to obtain free copies of the proxy statement/prospectus/information statement and other documents filed by STI with the SEC by written request to: Superconductor Technologies Inc. 9101 Wall Street, Suite 1300, Austin, TX 78754, Attention: Corporate Secretary. Investors and stockholders are urged to read the proxy statement/prospectus/information statement and the other relevant materials when they become available before making any voting or investment decision with respect to the proposed transaction. The information in the websites of STI and Clearday is not incorporated into this press release and will not be incorporated into such SEC filed documents.

No Offer or SolicitationThis communication shall not constitute an offer to sell, the solicitation of an offer to sell or an offer to buy or the solicitation of an offer to buy any securities, nor shall there be any sale of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. No offer of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933, as amended.

Participants in the SolicitationSTI and its directors and executive officers, and Clearday, and its directors and executive officers, may be deemed to be participants in the solicitation of proxies from the stockholders of STI in connection with the proposed merger. Information regarding the special interests of these directors and executive officers in the proposed merger will be included in the proxy statement/prospectus/information statement referred to above. Additional information about STIs directors and executive officers is included in STIs definitive proxy statement, filed with the SEC on April 26, 2019. These documents are available free of charge at the SEC website (www.sec.gov) and from the Corporate Secretary of STI at the address above.

Forward-Looking StatementsAny statements in this press release that are not statements of historical fact constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These statements include, but are not limited to, statements regarding the proposed merger and other contemplated transactions (including statements relating to satisfaction of the conditions to and consummation of the proposed merger, the expected ownership of the combined company and opportunities relating to or resulting from the merger), and statements regarding the nature, potential approval and commercial success of Clearday and its product line, the effects of having shares of capital stock traded on the Nasdaq Capital Market, Cleardays and the post-merger combined companys financial resources and cash expenditures. Forward-looking statements are usually identified by the use of words such as believes, anticipates, expects, intends, plans, ideal, may, potential, will, could and similar expressions. Actual results may differ materially from those indicated by forward-looking statements as a result of various important factors and risks. These factors, risks and uncertainties include, but are not limited to: risks relating to the completion of the merger, including the need for stockholder approval and the satisfaction of closing conditions; risks related to STIs ability to correctly estimate and manage its operating expenses and its expenses associated with the proposed merger pending closing; the cash balances of the combined company following the closing of the merger; the ability of STI to remain listed on the Nasdaq Capital Market; the risk that as a result of adjustments to the exchange ratio, STI shareholders or Clearday stockholders could own more or less of the combined company than is currently anticipated; potential adverse reactions or changes to business relationships resulting from the announcement or completion of the proposed merger; the success and timing of regulatory submissions; regulatory requirements or developments; changes in capital resource requirements; and other factors discussed in the Risk Factors section of STIs most recent annual report, subsequent quarterly reports and in other filings STI makes with the SEC from time to time. Risks and uncertainties related to Clearday that may cause actual results to differ materially from those expressed or implied in any forward-looking statement include, but are not limited to: Cleardays plans to develop and commercialize its future daily care centers and other non-residential daily care services; Cleardays commercialization, marketing and implementation capabilities and strategy; developments and projections relating to Cleardays competitors and its industry; the impact of government laws and regulations; and Cleardays estimates regarding future revenue, expenses and capital requirements. In addition, the forward-looking statements included in this press release represent STI and Cleardays views as of the date hereof. STI and Clearday anticipate that subsequent events and developments will cause their respective views to change. However, while STI and Clearday may elect to update these forward-looking statements at some point in the future, STI and Clearday specifically disclaim any obligation to do so. These forward-looking statements should not be relied upon as representing STIs or Cleardays views as of any date subsequent to the date hereof.

Investor Relations ContactMoriah Shilton or Kirsten Chapman, LHA Investor Relations, +1-415-433-3777 invest@suptech.com

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Superconductor Technologies and Allied Integral United, Inc. (Clearday) Announce Merger Agreement - Yahoo Finance

SHUFFLING through Central Station yesterday morning, with all the bounding, thrusting dynamism of the Polynesian hermit crab embarking on the molting process, I made a promise to myself to dispense with the meandering, long-winded introductions to these Tuesday twitterings and get straight to the point.

Lets face it, the weekly wafflings tend to go on longer than the announcement for the Glasgow to Penzance cross country train; you know that one that calls at Motherwell, Haymarket, Edinburgh, Berwick-upon-Tweed, Morpeth, Newcastle, Durham, Darlington, York, Leeds, Wakefield Westgate, Sheffield, Chesterfield, Derby, Tamworth, Birmingham New Street, Cheltenham Spa, Bristol Parkway, Bristol Temple Meads, Taunton, Tiverton, Exeter St Davids, Newton Abbot, Totnes, Plymouth, Liskeard, Bodmin Parkway, Par, St Austell, Truro, Redruth, Camborne, St Erth and Penzance.

What was I saying about meandering introductions again? Oh sod it

YOUNG GUNS SHINE BUT LANGER GOES ON AND ON

You cant hang about in this game. A quick perusal of recent winners on the various golfing tours can make you feel older than Methuselahs nibbie. A couple of 21-year-olds, Sami Valimaki and Im Sungjae, won the Oman Open and Honda Classic respectively while 18-year-old Julia Engstrom captured the New South Wales Open on the Ladies European Tour. The previous week, the Ladies Australian Classic was won by the 19-year-old amateur, Stephanie Kyriacou.

Its the kind of youth movement that should come with its own rallying cry from Greta Thunberg. You often hear folk spouting the observation, ah, its a young persons game nowadays but then Young Tom Morris won four Opens by the age of 21 and the last of those came in 1872.

Bernhard Langer, meanwhile, was 17 when he won the German National Open back in the 1970s. Here in 2020, the indefatigable auld yin is savouring his 41st win in the over-50s ranks at the age of 62. Its a remarkable plunder and one that is just four shy of the Champions Tour record held by Hale Irwin.

Langers competitive longevity once again underlines the fact that the passing years are no barrier to success. In an age, however, when bodies are often pushed to the physical boundaries amid increased athleticism and the quest for more power, how many of the current young uns will still be marching on at Langers vintage? Only time will tell.

RUGBY TV DEAL STIRS OLD GOLF DEBATE

The R&As annual media round table is an Arthurian-style assembly of the great and the good from the golf writing fraternity during which all pretence of knight-like chivalry goes flying out the window when the complimentary finger buffet gets served up. As always, the gathering was an open forum in which all manner of topics were discussed even if Martin Slumbers, the R&As chief executive, answered some of them with the kind of straight bat youd get in an early innings at Taunton.

The old chestnut about The Open being behind a pay-wall on Sky television cropped up and, just a few days later, news emerged that the Six Nations rugby could be disappearing from terrestrial platforms. Like the outcry that greeted golfs departure to Sky in 2016, similar concerns about the effects on inspiration and participation, among other issues, have already been raised in worried rugby circles.

At the 2017 Open, Slumbers stated that, I dont buy the argument around participation and reach, when asked about the impact in the UK of golf going to Sky before adding that, it is clearly good to have more reach, but The Open is a global product, its not just a UK product. We touched 600 million households last year around the world.

It was something of a contradiction because reach is either important or its not. Last week, meanwhile, Slumbers urged troubled golf clubs to, well, reach out to new markets. As we all know thats easier said than done and, in many ways, golfs chronic lack of exposure does not help that cause.

There are a variety of sports that get visibility and presence on terrestrial television that triggers a clear benefit in terms of public consciousness. Golf, sadly, muddles on in the margins. When it comes to The Open on the tele, many on these shores have a dewy-eyed yearning for that long, uninterrupted, come-all-ye coverage of yore. Watching through rose-tinted spectacles? Well, its better than not watching at all.

AZINGER STIRS POT WITH RABBLE ROUSING

Paul Azingers cheap, insular belittling of the achievements of Tommy Fleetwood and Lee Westwood during his Honda Classic punditry has gone down like an entire lead balloon rally on this side of the pond. In a Ryder Cup year, the phoney war has started it seems.

Azingers comments lacked class. But then, what was it Seve once said? The American team is made up of 11 gentlemen and Paul Azinger.

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Langer's longevity, The Open on TV and Azinger's crass comments - HeraldScotland

An interesting and well-done study from a cohort of ageing men in the Netherlands that evaluated how alcohol consumption data collected at 68-to-70 years oldrelated to the risk that the individual would survive to age 90. The authors concluded: "The highest probability of reaching 90 was found in those consuming 5-to-<15 grams per day alcohol, with RR=1.36 (95% CI, 1.201.55) when compared with abstainers."

The latest critique from the ISFAR looks at research into alcohol consumption and its relationship with reaching 90

The authors also noted that "wine intake was positively associated with longevity (notably in women), whereas liquor was positively associated with longevity in men and inversely in women".They also noted there was a tendency for a lower chance of living to age 90 for subjects reporting binge drinking.

ISFAR members were unanimous in considering this to be an excellent study. The findings addinformation on alcohol consumption collected in the elderly (aged 68-to-70 in this study) and subsequent longevity of life. They also tendto counter fears expressed by some that the very elderly must be 'protected' from alcohol, as it suggests there are still health benefits from moderate drinking at all ages. Further, a reduction in the risk of cardiovascular diseases associated with alcohol is especially important in the elderly, as such diseases occur primarily among such subjects and are the leading causes of death.

This ISFAR critique provides references to a multitude of research reports that strengthen the conclusions of the authors that, even among very elderly subjects, moderate drinking is associated with a greater longevity of life.

To read the full critique, click here.

These critiques are published with the permission of The International Scientific Forum on Alcohol Research.

Click here for all of the critiques from the International Scientific Forum on Alcohol Research

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Will your alcohol consumption help or hinder you from reaching 90? - International Scientific Forum on Alcohol Research Critique 237 - just-drinks.com

In a world that seems to be obsessed with size, theres a strong emphasis on having certain body parts be as big as possible, from breast implants to butt injections. That said, the need for a bigger size has resulted in the huge growth of the penis enlargement industry.

The average penis size is 5.2 inches (13.2cm) long and 4.6 inches (11.6cm) round. Now, while the debate on whether size matters rages on, it appears that some men have already made up their minds. Believing that it does indeed matter, these men, who feel under-endowed, have taken matters into their own hands by looking at pills, creams, and even vacuum pumps. However, it doesnt end there. Enter, penis fillers.

Yes, penis fillers. A non-surgical procedure, that can cost around $5000, whereby a liquid usually hyaluronic acid is injected into the soft tissue under the skin of the penis shaft. The purpose of the procedure is meant to increase a mans flaccid girth, usually by one or two centimeters in circumference and the effects are intended to last for around 18 months.

Additionally, some clinics use fat injections to increase girth. The fat is harvested from another part of the patients body, usually the lower abdomen. Unlike hyaluronic acid, fat injections are permanent.

Mr. Asif Muneer, from the British Association of Urological Surgeons, revealed to the BBC that he would discourage his patients from partaking in any form of penis enlargement surgeries,

All these augmentation procedures are mainly to increase your flaccid girth, and it will have no benefit on your erect length so functionally its not going to improve matters he explains, If anything, it might lead to complications that will impair their sexual function later on.

Additional side effects may also include painful bruising, swelling, infections, unevenness scarring. There may even be a heightened risk of erectile dysfunction due to blood vessel blockage. Whats more, there is also the risk of the filler ending up in the foreskin. This would then mean that the patient would require circumcision.

So, what exactly would possess a man to have hyaluronic acid or fat harvested from his body injected into his penis shaft?

When it comes to the impact that social media has on body image, a lot of the attention is focused on the womans perspective. However, the rise of social media and the influencers culture can also affect how men view themselves.

For instance, research published in the journal New Media and Society found that men who reported looking at male fitness posts on social media revealed that they regularly compared their appearance to others more often, and there was also an increased desire to have muscles.

It may not be premature to admit that the rise of penis enhancements goes beyond sexual satisfaction. With the constant innuendos about large sizes being more desirable, as well as men equating a large size to masculinity and sexual competence, some men may begin to have low self-esteem if they feel that their sizes arent up to standard. In fact, a study published in the journal Psychology of Men & Masculinity found that even men with average-size penises wish they were bigger.

Additionally, a recent study published in the Journal of Sex & Marital Therapy that asked for the male participants to self-report their penis length found that many of the men embellished their responses. In fact, only 26.9% of the sexually experienced men self-reported penis lengths of less than 6 inches. On the other hand, 30.8% self-reported lengths of 7 inches or more. Whats more, the study also suggested that men with a high level of social desirability were more likely than others to self-report having a large penis.

So with all of that said, theres only one question left to ask;

Kindness.

According to a study from Clue, that surveyed at 64 000 women, kindness is the most important thing women look for in a partner not the size of a shaft. Speaking of which, the survey also revealed that the majority of straight women would prefer a male partner to have an average-sized penis, rather than a massive penis. Thats right women care less about penis size than men.

In fact, women are more worried about it being too big as opposed to too small. This is because a bigger than average penis may cause some pain and discomfort during sexual intercourse. This then reduces the chances of more sex in the future. Whats more, there is also the consensus that men with big penises will solely rely on their size. As such, they will not be as engaging or conscious of their partners needs. This, of course, can result in a woman being very dissatisfied with her sex life.

To men, a big penis may sound like a lovely idea in theory, but theres really nothing to it. Rather, put your physical and mental health before anything else. After all, its not the size of the boat that matters, but rather the motion of the ocean.

Fatt, S. J., Fardouly, J., & Rapee, R. M. (2019). #malefitspo: Links between viewing fitspiration posts, muscular-ideal internalisation, appearance comparisons, body satisfaction, and exercise motivation in men. New Media & Society, 21(6), 13111325. https://doi.org/10.1177/1461444818821064

King, B., Duncan, L., Clinkenbeard, K., Rutland, M., et al.(2019)Social Desirability and Young Mens Self-Reports of Penis Size,Journal of Sex & Marital Therapy,45:5,452-455,DOI:10.1080/0092623X.2018.1533905

Johnston,L.,McLellan,T., &McKinlay,A. (2014).(Perceived) size really does matter: Male dissatisfaction with penis size. Psychology of Men & Masculinity,15(2),225228. doi:10.1037/a0033264

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Penis Fillers: The Hard Truth About If Size Really Matters - Longevity LIVE

SEATTLE Samira Ummat, MD of Longevity Medical Clinic says there is evidence that androgens (or hormones) like testosterone are breast protective in women.

"Unfortunately, all women after mid-thirties, become deficient in many important hormones. In recent studies, its true, there is an 86% reduction in breast cancer cases when high-risk women were on androgen therapy. "

How does a woman know if she is at high risk for Breast Cancer?

According to Dr. Ummat, women who are at high risk for Breast Cancer often have above-average menopausal symptoms with lots of side effects. Some women breeze through menopause and other women get hammered with mood swings, hot flashes, low libido, and bone loss. The more problems you have, the higher the risk, and the more problems you can get. Plus, some women have genetic predisposition, make poor lifestyle choices, like smoking, living a sedentary lifestyle, lack of exercise, becoming obese, too much alcohol, poor diet, too much radiation, late menopause, and delayed childbearing. The danger of being overweight is the fat tissue, like visceral fat, is a hormone factory, but it can create too much of the wrong hormones.

To know risk and whether you are getting the right treatments Longevity Medical Clinic, starts with measuring first, if you dont measure, you dont know.''

SPECIAL OFFER: Schedule a free Health Analysis at Longevity Medical Clinic to take a valuable step in understanding how you are aging. During your appointment we will: Take the time to listen to you and your body; Discuss your primary health concerns; Determine your health risks through two free tests; Review your initial health screenings, offering options for a healthier future.

Call Longevity Medical Clinic if you have any questions: 1-866-86YOUNG (866-869-6864)

Longevity Medical Clinic's Health offers a Free Health Analysis: longevitymedicalclinic.com

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Sponsored by Longevity Medical Clinic.Segment Producer Suzie Wiley. Watch New Day Northwest 11 AM weekdays on KING 5and streaming live on KING5.com.

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Androgen therapy looks promising for high-risk breast cancer patients - KING5.com

Researchers at the University of Arizona are developing wearable technology to analyze sweat, which may remove the need to draw blood to learn about the bodys functions in multiple situations.

The project is funded by an 18-month, $519,000 grant from the SEMI Nano-Bio Materials Consortium. The project falls at the crossroads of multiple academic fields, including engineering, chemistry and medicine, and has two main goals: develop a patch to reliably collect the sweat, and develop a biochemistry sensor to analyze the sweat.

When physicians take blood samples, the blood is tested for "biomarkers" which are indicators of medical phenomena like disease or infection. Sweat contains its own index of biomarkers, and collecting it presents a unique series of challenges and advantages.

No matter what molecule you measure in sweat, you need to determine how it relates to the physiological status of the individual, says co-investigator Esther Sternberg, who serves as research director for the Andrew Weil Center for Integrative Medicine and UA professor of medicine. In order to measure the status of the immune system without stressing an individual, one needed to get at immune molecules in a different way than drawing blood, because if you draw blood you need to stick a needle in a person, and thats a stressor If youre trying to understand how the stress response affects the immune response, you need to have a noninvasive, unobtrusive way of measuring the status of the immune response.

Sternberg began working with biomarkers in sweat 20 years ago while working at National Institutes of Health. She says one of the reasons she was drawn to the UA was because of interdisciplinary research projects such as this.

Part of understanding biomarkers in sweat involves using a sweat correlation lab where subjects use exercise bikes to have their sweat collected in a controlled environment.

Were able to relate the levels of the different biomarkers to the exact amount of stress that their bodies are experiencing because we correlate them with heart rate, heart rate variability, breathing and other well-standardized methods to accurately measure the activity of the brain and bodys stress response, Sternberg says. Just measuring the molecules is just the tip of the iceberg, you need to correlate them with all these different measures of the status of the physiological stress response in order to understand what they mean and have actionable results.

One of the first hurdles is how to accurately and quickly collect the sweat. According to project principal investigator Erin Ratcliff, a materials science and engineering professor and head of the UA Laboratory for Interface Science of Printable Electronic Materials, the obvious idea to collect sweat would be to make a patch to gather information from multiple pores at once. However, this means waiting for the space between the patch and skin to fill up with sweat, and during that time, the molecules and biomarkers can chemically change, altering important information.

Ratcliff became involved in this project five years ago, and her role is to convert the biomarkers into an electronic signal that devices use. Current wearable technologies, such as a FitBit, measure bodily data like EKG and heart rate, but dont measure the molecules behind the stress responses, such as cortisol or neuropeptide Y.

Part of the project uses a virtual sweat sensing lab which is a computer simulation that allows researchers to input information about biomarkers, printable materials and device architectures to determine what the output of a sensor would be before they ever make it.

The prototypes that will come out of this 18-month project will be laboratory level with the idea that the components will lead to a product stream for a particular company, but were not going to make thousands of them, Ratcliff says.

While Sternberg says measuring sweat has a tremendous and very wide applicability to many different diseases, it will not completely remove the need to draw blood.

Youre getting information from two different compartments of the body; the blood tells you whats going on in the blood and circulatory system, and sweat tells you whats going on in the tissues and peripheral nervous system I believe this will enhance information and give you information that is not present when you only measure molecules in blood, Sternberg says. Ultimately there may be circumstances in which collecting sweat and collecting molecules from sweat will replace the need to measure the molecules in blood, and in other cases to get a full picture of whats happening in the body, you may need to measure sweat, blood, saliva, urine and on and on.

The U.S. Department of Defense measures "technology readiness" throughout nine levels. According to Ratcliff, the team is aiming for the technology to be at level four at the end of this project. Technology Readiness Level Four means that "basic technological components are integrated to establish that they will work together.

This speaks to the importance of academe and industry working together in an unbiased way, together with federal agencies, to solve complex problems which cant be solved only on the academic side or only on the industry side, Sternberg says. This is an interdisciplinary, multi-college collaboration with an engineer of materials science in Erin Ratcliff, a chemist Ray Runyon, and myself a physician When youre talking about cutting-edge, frontier science, that is the way science has to be done.

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UA developing wearable technology to measure sweat 'biomarkers' - Tucson Local Media

The global Nanomedicine market report by HNY Research offers users a detailed overview of the market and all the main factors affecting the market. The study on global Nanomedicine market, offers profound understandings about the Nanomedicine market covering all the essential aspects like revenue growth, supply chain, sales, key players and regions. There is a target set in market that every marketing strategy has to reach. This report on Nanomedicine focusses on different categories that define this market with a systematic approach that addresses the consumer base, researchers and market experts like the stakeholders. It also gives a clear perspective towards the competition and demand and supply chain.

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2020-2025 Global and Regional Nanomedicine Industry Production, Sales and Consumption Status and Prospects Professional Market Research Report -...

To keep your sight in the best of its ability, we bring you a list of sensible food and habit choices that can keep them healthy, wealthy and vivid!

March 3, 2020 4 min read

You're reading Entrepreneur India, an international franchise of Entrepreneur Media.

Use to spending ample time on your mobile and laptop? Prolonged uses of these devices have become a part of our day to day lifestyle. While we cant avoid the same as our work-life revolves around it, we can surely make some alterations in our life for our good. With an increase in the usage of screen-time, taking care of your eye has become essential than ever.

Eyes are vascular; hence a healthy diet with low Trans and saturated fat is a must. Period!

In order to guard them from age-related macular degeneration (ARDM), one needs to intake food supplements rich in antioxidants. To keep your sight at its best ability, we bring you a list of sensible food and habit choices that can keep them healthy, wealthy and bright!

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9 Sensible Tips to Boost Eye Health and Maintain Sharp Vision - Entrepreneur

Optometrist Eileen Hanley graduated with honours from Dublin Institute of Technology in 1988. She is a Fellow of The Association of Optometrists, and one of the team at Eye Contact Opticians, Tullamore, Co Offaly. Here she shares some of their tips and advice for eye care.

The majority of adults are entitled to a free eye examination using PRSI entitlements, or a Medical Card.

HSE eye screening is usually carried out during the first year of primary school. However, earlier testing is advised, particularly if there is a family history of vision or ocular issues. The critical visual development period is between ages 2-7. Early detection and management prevents longterm visual damage, and maintains binocular vision use of both eyes allowing depth perception.

Holding near material away, or having no interest in close work tasks, may indicate long sightedness (hyperopia). Sitting close to the TV, being unable to read number plates or recognise people on the street, and being unable to read the white board at school, are all indications of myopia (short sightedness).

Advances in myopic control are now available which can slow progression, including a new type of daily contact lens and drug therapies.

Using hand-held devices may increase the progression of myopia.

Holding reading material or your phone further away as you age is a sign of presbyopia, the loss of lens elasticity causing long-sightedness in middle age.

The absence of red-eye reflex in one eye in a photograph, when present in the other eye, needs further investigation to rule out retinoblastoma, a type of eye tumour.

In addition to visual requirements, eye examinations can detect systemic conditions, such as diabetes, cardiovascular disease, autoimmune disorders, and tumours. Certain prescription changes may indicate a fluctuation in blood sugars or the development of cataracts. Symptoms such as doubling of vision, visual field loss, intermittent vision loss, flashes, and floaters may require further medical intervention. Every day as an optometrist is different.

Keeping hydrated is important for eye health, and helps prevent dry eyes.

Hay fever, allergies, and autoimmune diseases may cause tear disruption. Women can suffer more from dry eyes when oestrogen levels drop before menstruation and during menopause. Artificial tears can help.

Avoid heat and fans directed into the eyes ( eg car air-conditioning, ovens, and simmering pots) to prevent tears evaporating.

Foods rich in vitamins A, C and E, and zinc and lutein, can help with macular degeneration and eye health. These include green leafy vegetables, corn, egg yolks and kiwis. Flaxseed oil helps maintain the health of your tear film.

Always wear protective eyewear during DIY and gardening, especially strimming, to prevent eye injuries.

Wash hands after contact with animals, in particular dogs and cats, to prevent toxocariasis. This can cause serious eye infections and even be sight threatening.

Ultra violet rays damage skin and eye health. There are strong links between exposure to UV rays and the incidence and severity of cataracts, pterygium, macular degeneration, and eyelid cancers. Sunglasses that filter out harmful UVA and UVB rays will be labelled UV 400 CE.

Follow prescription recommendations for all eyewear. If you dont wear your near-correction glasses as required, especially after the age of 50, you dramatically increase the risk of affecting your distance vision.

Red eye conditions can be caused by: irritants such as dry air or exposure to excess heat (eg the sun or welding); allergic reactions; dust; colds; trauma; and infections.

There are three types of conjunctivitis, bacterial, viral and allergic. Bacterial conjunctivitis will always have a discharge. Viral and allergic will cause a clear, weepy, runny eye. To prevent bacterial conjunctivitis spreading, ensure hands are washed thoroughly, use separate hand towels, and clean door knobs and surfaces touched by the infected individual.

Red eye with vision impairment is usually uveitis inflammation or corneal ulcers, which may be caused by shingles or the cold sore virus. Other causes of red eye include acute glaucoma, corneal abrasion, scleritis/episcleritis (inflammation of the white of eye), styes, and chalazions.

If you have red eyes with vision impairment, pain, or light sensitivity, seek immediate medical attention. To determine the cause an examination with slit lamp magnification is essential. Every optometrist has this equipment, and they can also guide you to the best place for further treatment, if required, as not all A&E departments have an attending ophthalmologist.

The average person blinks 15-20 times per minute. This reduces to 1-2 times per minute while we are on screens. It is important to blink often when using screens. Every time you tap the enter key of your keyboard or phone, blink and look away.

The blue light emitted from digital devices can cause eye strain, reduce the levels of contrast you perceive, and disrupt sleep by depressing secretion of the hormone melatonin. Using a blue filter on devices, or an anti-glare with blue filter coating on spectacles, will minimise these effects.

Use the 20/20/20 Rule; for every 20 minutes of screen time look at something 20 feet away for 20 seconds. This enables the eyes lens to readjust and refocus.

Never squeeze styes and chalazions. These, and blepharitis inflammation of the eyelash follicles can be treated with warm compresses, by placing a cottonwool pad moistened with cooled boiled water on the eye. Dip a cotton bud into cooled boiled water to massage the lids, rolling it along where the lash meets. Bicarbonate of soda may be dissolved in the water quarter teaspoon to quarter pint but never use baby shampoo. This can disrupt the eyes tear film. Warm compressing eye-masks and wipes, available in pharmacists and opticians, are convenient alternatives.

If you get something in your eye artificial tears may flush it out. A loose eyelash on the white of the eye can be moved towards the lower lid for removal using a cotton bud dampened with cooled boiled water.

Blowing your nose may help move a loose eyelash to the corner of the eye for removal.

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Expert tips: An optometrist on how to look after your eyes - The Irish Times

Columbus, OH (March 2, 2020 ) Ohio Delegates David Monder (Hilliard), and Tari Hodge (Lewis Center) joined delegates from across the country for the fifteenth annual Prevent Blindness Eyes on Capitol Hill advocacy day on Wednesday, February 26, 2020 in Washington, D.C.

Since 2006, the Ohio Affiliate of Prevent Blindness and its national office have brought citizens from across the country to meet with members of the House and Senate, and their staff, to discuss the importance of vision and eye health programs and research.

We are proud to continue to work with members of government through our Eyes on Capitol Hill event, as well as other local and national advocacy efforts, to help protect the gift of sight and continue to bring Americans to quality, affordable eye care, said Sherry Williams, President & CEO of Prevent Blindness, Ohio Affiliate.

According to the recent Prevent Blindness study The Future of Vision: Forecasting the Prevalence and Costs of Vision Problems, vision impairments are projected to cost the United States $167 billion in 2019, due in large part to the aging population. Yet, for every $18,600 that vision problems cost the country, only a single dollar is allocated to the Centers for Disease Control and Prevention (CDC) toward their prevention. Annual costs are projected to increase to $717 billion by 2050 without significant investments in vision and eye health.

This years Eyes on Capitol Hill advocates visited with the offices of United States Senators Rob Portman and Sherrod Brown and United States Representatives Tim Ryan, Marcy Kaptur, Robert Latta, Bill Johnson, Troy Balderson and Steve Stivers and asked these elected officials to:

.Invest $5 million in funding for the CDCs Vision Health Initiative to conduct much-needed surveillance.

.Maintain the CDCs work in glaucoma prevention and awareness with $4 million.

.Support continued investments to the National Eye Institute (NEI) that will enhance the scope of research to support public health objectives of early detection, prevention, and population health.

Prevent Blindness has also established the Prevent Blindness Policy Roadmap to guide efforts at the federal level to effectively save sight, and to help provide cost effective solutions to government entities, private institutions, and patients.

For more information on Eyes on Capitol Hill, or Prevent Blindness and its advocacy initiatives, please call 800-331-2020 or visit http://www.pbohio.org.

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Ohio Residents Visit Washington to Advocate for Support for Programs, Research to Save Sight WKTN- A division of Home Town Media - WKTN Radio

Ganjam: Allergan, Sightsavers and the International Agency for the Prevention of Blindness (IAPB) today announced the launch of its unique joint initiative Keep Sight India a community based glaucoma screening progamme to prevent glaucoma-related vision loss in Ganjam District, Odisha. The pilot kicked off in October 2019 in partnership with Sightsavers local partner, Sankara Eye Hospital.

Theprogammeprovidestrainingforhealthcareprofessionalstoscreenat-riskpopulations,ensureearlyand accurate diagnosis and provide appropriate treatment and long-term care in an effort to make a positive impact on people with glaucoma at all levels of comprehensive eyecare.

The first outreach camp was organised on December 3rd, 2019 on World Disability Day and subsequently four outreach camps were conducted under the pilot project. The outreach camps included services like vision testing, refraction, IOP measurement, fundus photography, spectacle dispensing, cataract identification, referral services and counselling services. To date 8276 people have been screened for glaucoma in these fouroutreachcamps,fromwhich749glaucomasuspectswereidentifiedandreferredtothebasehospital.2

Sightsavers India CEO, RN Mohantysaid: We are excited to be partnering with Allergan, an organisation with a long legacy in eyecare. Sightsavers too like Allergan is committed in finding and providing effective solutions for patients suffering with glaucoma, which is one of the leading causes of irreversible blindness. Thetypicalbarrierswefaceongroundincludeinadequatehumanresources,alackofawarenessandlimited access to medical treatments. The partnership between Sightsavers and Allergan is an example of the vital associations that are needed to fight avoidable blindness and deliver better services at the community level.

1https://www.nhp.gov.in/world-glaucoma-week_pg

2Taken from output statistics in Keep Sight monthly reports. Further details available from Sightsavers Media team

DrSYQuraishi,HonoraryChairmanSightsaversIndiaBoardandformerChiefElectionCommissioner,Indiasaid, Nearly 75% of sight loss can be cured or prevented, so its an area where initiatives like this can have a strong impact where it is needed the most. Im happy to know that people in and around Ganjam will become aware about Glaucoma and take adequate corrective measures which are now accessible via eye screening camps in the community and services at the Sankara Eye Hospital,Samarjhola.

India will play a crucial role in meeting WHOs targets for eye health, saidJoanna Conlon, Director of Development and Communications, IAPB. The country is already at the forefront of delivering people- centered solutions for eye care. Keep Sight will work with Indian partners to support and extend Indias successes around eye health and glaucoma. IAPB is committed to universal eye health. Sightsavers has decadesofexperienceindeliveringeyehealthintheregion.TogetherwithAllergan,theyarekeentomake a real difference for people with Glaucoma. Together, we will work to support Indias eye carestrategies.

Allergan is honoured to partner with Sightsavers and IAPB onKeep Sight; their wealth of knowledge and expertise,combinedwithourpassionforscienceandsolutionswillhavearealimpactonoursharedgoalof reducingthehighburdenofirreversibleblindnessinthecountry.ForalmosttwodecadesAllerganhasbeen committed to developing novel approaches to preserve visual function and prevent blindness caused by glaucoma.KeepSightisaninitiativethatwillmakearealdifferencetopeoplewithglaucomainIndia.saidGopinath Kesavan, Associate Director, Eyecare, AllerganIndia

Keep Sight India Project Update

The outputs of the programme achieved up until January 2020 are detailed below. The outputs include numbers from both outreach and hospital interventions.2

2020)

Yag PI)

Plan for next Quarter (Jan-Mar 2020)

The next quarter of the project will focus primarily on the following activities:

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Allergan, Sightsavers And The Iapb Announce The 'Keep Sight' Initiative To Address Glaucoma In Ganjam, Odisha - Odisha Diary

Karthiks Tamil teacher beat him in the class on February 5 following which he had been complaining of eye pain and headache.

In a shocking incident, a 15-year-old boy in Chennai has lost vision in one eye, allegedly after his teacher hit him on the head in school. Karthik now awaits treatment in Rajiv Gandhi Government General Hospital in the city for a surgery that may save his eyesight.

The incident took place a month ago, on February 5, in the Government Higher Secondary school, Medavakkam. According to Karthiks mother Rekha, his teacher had allegedly beaten him with a ruler in the class, when he spoke back to her on some issue. Karthik who came back home from school that evening narrated the ordeal to his mother and has not gone to school since then.

He has been complaining of headache and eye pain since that day and has not gone to school since February 5. His left eye started reddening and swelling and he started complaining that he is not able to see clearly. That was the point we took him to a doctor, she said.

Karthik has reportedly lost vision in his left eye and is awaiting medical attention as on Wednesday. We are still in the hospital and he is in pain. Doctors are taking forever to attend to us and hence it is causing inordinate delay in his treatment, Rekha rued. She also said that they had submitted a written complaint in Pallikaranai police station but is yet to receive a copy of the FIR registered against the erring teacher.

I want justice for my child. The authorities must do a fair inquiry and sack the teacher who rendered my son blind in one eye. Thats all I want, she added.

Speaking to TNM, a policeman from Pallikaranai station said that an FIR is yet to be registered in the case. The boys parents have not furnished all the details like phone number to register an FIR. We have just got a complaint. We are conducting an inquiry on the issue and will take action on it, the policeman said.

The Chief Educational Officer (CEO) of Kancheepuram is yet to respond to TNM's queries on the issue. The story will be updated as and when we receive a response.

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15-year-old Chennai boy loses vision in one eye allegedly after teacher hits him - The News Minute

(PRESS RELEASE) RightEye LLC revealed the six finalists of its 2020 RightEye Impact Awards. This program was created to recognize, honor and celebrate the many unsung accomplishments of healthcare providers worldwide who are transforming peoples lives through measuring and treating functional vision health. RightEye is an eye movement biomarker company using eye-tracking technology to revolutionize health care and to help more accurately identify health and vision issues. The RightEye Impact Awards received submissions from across the United States as well as from Australia, the Netherlands, Albania and Canada. The grand prize winner will be honored at a ceremony on March 13 in the winners hometown.

The finalists were judged based on the magnitude of clinical progress and the patients improved quality of life. Each provider used RightEye in some way to enable progress, including communicating dysfunction, validating problems, providing solutions, and changing the mindset of patients and families by demonstrating treatment progress. Award applicants used a variety of RightEye tests including Brain Health, Reading, and Functional Vision as well as RightEyes EyeQ Trainer for improving oculomotor dysfunction.

RightEye is helping to improve lives for those affected by many different kinds of issues, such as concussion, dyslexia, Parkinsons, learning disabilities, and more, said RightEye CEO Adam Gross. At the same time, we are providing healthcare providers with a groundbreaking, FDA-cleared tool to help them improve patient care while expanding their practices.

Many people impacted by these problems may never realize that eye movement testing and treatments that address visual/brain processing can actually make a huge difference for them. Thats why we are shining a light on the most inspirational stories weve heard from our customers. Narrowing the field down to six finalists was more difficult than we expected because so many of the stories were absolutely incredible.

The finalists are:

1. Dr. Sally Fryer Dietz, Integrative Concussion & Pediatric Therapy, Dallas, TXA 13-year-young woman was diagnosed with dyslexia and had been receiving remedial work outside of the clinic. After a RightEye assessment and sensory motor evaluation, Dietz realized the patient was actually not dyslexic and the problem was more related to a visual tracking issue and SI Dysfunction. Following treatment, her scores went up dramatically to several grade levels above where she had initially tested. The patients self-esteem and confidence skyrocketed, along with her ability to memorize scripts and read advanced level books.

2. Debra Holtzhauer, Listowel Vision Care, Listowel, Ontario, CanadaA 34-year-old female patient was kicked in the head and her resulting concussion left her with persistent pain and vision issues that impacted her ability to sew, cook, drive, read, etc. After a RightEye test and vision therapy, all symptoms were eliminated or greatly reduced. Pain meds were no longer needed and she was able to resume her daily activities.

3. Jeremiah Jorgensen, Fyzical Therapy and Balance Centers, Lincoln, NEA 7-year-old child was diagnosed with a learning disability and was receiving occupational therapy, physical therapy and speech therapy. After a RightEye test it became clear that a vision issue made it difficult to read and limited her depth perception. Within six weeks of treatment, her spelling and reading tests put her at or near the top of her class, and three months later she rode a bike for the first time in her life. Due to RightEye we not only changed a childs life but her father was in tears for helping him enjoy time with his daughter as she can now enjoy childhood tasks and games that most parents take for granted.

4. Dr. Amanda Nanasy, Florida Institute of Sports Vision at The Eye Center, Pembroke Pines, FLA college-aged patient had suffered a concussion from a motor vehicle accident and had been under the care of a concussion rehab doctor who did not utilize visual treatment or care. The patient wore glasses and walked with a lean to the side due to poor fixation. Following RightEye testing and prescription of new prisms, he no longer needed glasses, and his lean disappeared.

5. Dr. Neil Renaud, EagleEye Performance Vision, Holland, MIAn 11-year-old patient was struggling with schoolwork, experiencing blurry and double vision, as well as attention issues, poor comprehension, clumsiness and poor handwriting. He was preparing to end his education at the high school level and embark on a blue-collar career that didnt require reading. Following a RightEye test, Renaud diagnosed oculomotor dysfunction of pursuits, saccades, and fixations. After completion of vision therapy, the patients performance in reading, handwriting, and ability to pay attention improved drastically and blurry and double vision became non-existent. He now plans to go to college to become an optometrist.

6. Dr. Gregory Schultz, Eye Center of Virginia, Williamsburg, VAA CEO of a growing company suffered a concussion after hitting her head on a concrete floor. Symptoms included extreme dizziness, unsteady gait, headaches, confusion, memory issues and delayed reaction time, along with reading ability now at a fourth-grade level. She was told by a neurologist the symptoms would be temporary but she saw no improvement after several months. Following a RightEye test she was diagnosed with multiple deficiencies in horizontal tracking, fixations, horizontal saccades and visual recognition and reaction time. After four months of treatment with RightEyes EyeQ Trainer, the patient has experienced improvements in tracking, saccades and fixations, with corresponding improvements in function.

Continued here:
AOA Partners With Lyft To Offer Free Rides to Get Comprehensive Eye Exams - InvisionMag

World Cup winning captain Kapil Dev has actually explained poor people as a type of Virat Kohli, who was simply flopping on New Zealand trip, while the result of their poor vision. The veteran all-rounder feels that batsmen need deal with this dilemma while they get older and Kohli will need to shape himself in accordance with their vision.

Kapil informed 'ABP News', "Such a period will come in the job of each huge batsman.

->It is age, it is known that after 30 several years of age, vision becomes poor also it takes 6 months to 1 12 months to obtain familiar with it. I do believe he (Kohli) has to adjust in accordance with their eyesight. When big players tend to be bold and lbw on your golf ball, then you definitely need question them to train much more.

The previous captain stated that numerous batsmen such as for example Virender Sehwag, Rahul Dravid and famous batsman Vivian Richards needed to deal with comparable dilemmas.

ICC Women's T20 World Cup: semi-final schedule decided; Know which team India will face whenever

Kapil stated, "It suggests that your eyes and capability to react have grown to be notably poor. Your eyesight is way better for 18 to 24 years, but then it relies on the method that you focus on it. Sehwag, Dravid, Viv Richards all experienced such troubles inside their jobs. That's why Kohli has to exercise much more. ''

The 31-year-old Kohli managed to rating just 38 operates at the average of 9.50 when you look at the Test series played in the New Zealand trip. Earlier when you look at the minimal overs show, he scored 180 works with the aid of a half-century.

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Kapil Dev says Virat Kohli will be eliminated as a result of poor vision - Sahiwal Tv

Regulatory News:

GenSight Biologics (Paris:SIGHT) (Euronext: SIGHT, ISIN: FR0013183985, PEA-PME eligible), a biopharma company focused on discovering and developing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, announced today that the bilateral visual recovery observed with GS010 (LUMEVOQ) in the REVERSE and RESCUE Phase III trials will be presented and discussed at the 46th Annual Meeting of the North American Neuro-Ophthalmology Society (NANOS) - Amelia Island, Florida - March 7-12, 2020.

Dr. Nancy J. Newman, MD, LeoDelle Jolley Professor of Ophthalmology and Neurology at the Emory University School of Medicine in Atlanta, GA, USA, and widely recognized as one of the leading authorities on Leber Hereditary Optic Neuropathy (LHON), will discuss the findings from the two trials in the context of LHON natural history and other relevant studies. Dr. Newman has been instrumental in defining and describing LHON pathophysiology and clinical declarations and is an International Principal Investigator and Site Principal Investigator of GS010 (LUMEVOQ) Phase III trials.

North American Neuro-Ophthalmology Society (NANOS)

March 7-12, 2020 Amelia Island (FL, USA)

"Bilateral Visual Improvement with Unilateral Gene Therapy for Leber Hereditary Optic Neuropathy (LHON)" presented by Nancy J. Newman, MD, LeoDelle Jolley Professor of Ophthalmology and Neurology, Emory University School of Medicine, Atlanta, GA

About GenSight Biologics

GenSight Biologics S.A. is a clinical-stage biopharma company focused on discovering and developing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders. GenSight Biologics pipeline leverages two core technology platforms, the Mitochondrial Targeting Sequence (MTS) and optogenetics to help preserve or restore vision in patients suffering from blinding retinal diseases. GenSight Biologics lead product candidate, LUMEVOQ (GS010), is in Phase III trials in Leber Hereditary Optic Neuropathy (LHON), a rare mitochondrial disease that leads to irreversible blindness in teens and young adults. Using its gene therapy-based approach, GenSight Biologics product candidates are designed to be administered in a single treatment to each eye by intravitreal injection to offer patients a sustainable functional visual recovery.

About LUMEVOQ (GS010)

LUMEVOQ (GS010) targets Leber Hereditary Optic Neuropathy (LHON) by leveraging a mitochondrial targeting sequence (MTS) proprietary technology platform, arising from research conducted at the Institut de la Vision in Paris, which, when associated with the gene of interest, allows the platform to specifically address defects inside the mitochondria using an AAV vector (Adeno-Associated Virus). The gene of interest is transferred into the cell to be expressed and produces the functional protein, which will then be shuttled to the mitochondria through specific nucleotidic sequences in order to restore the missing or deficient mitochondrial function. "LUMEVOQ" was accepted as the invented name for GS010 (lenadogene nolparvovec) by the European Medicines Agency (EMA) in October 2018.

About Leber Hereditary Optic Neuropathy (LHON)

Leber Hereditary Optic Neuropathy (LHON) is a rare maternally inherited mitochondrial genetic disease, characterized by the degeneration of retinal ganglion cells that results in brutal and irreversible vision loss that can lead to legal blindness, and mainly affects adolescents and young adults. LHON is associated with painless, sudden loss of central vision in the 1st eye, with the 2nd eye sequentially impaired. It is a symmetric disease with poor functional visual recovery. 97% of patients have bilateral involvement at less than one year of onset of vision loss, and in 25% of cases, vision loss occurs in both eyes simultaneously. The estimated incidence of LHON is approximately 1,200 new patients who lose their sight every year in the United States and Europe.

About RESCUE and REVERSE

RESCUE and REVERSE are two separate randomized, double-masked, sham-controlled Phase III trials designed to evaluate the efficacy of a single intravitreal injection of GS010 (rAAV2/2-ND4) in subjects affected by LHON due to the G11778A mutation in the mitochondrial ND4 gene.

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The primary endpoint will measure the difference in efficacy of GS010 in treated eyes compared to sham-treated eyes based on BestCorrected Visual Acuity (BCVA), as measured with the ETDRS at 48 weeks post-injection. The patients LogMAR (Logarithm of the Minimal Angle of Resolution) scores, which are derived from the number of letters patients read on the ETDRS chart, will be used for statistical purposes. Both trials have been adequately powered to evaluate a clinically relevant difference of at least 15 ETDRS letters between treated and untreated eyes adjusted to baseline.

The secondary endpoints will involve the application of the primary analysis to bestseeing eyes that received GS010 compared to those receiving sham, and to worseseeing eyes that received GS010 compared to those that received sham. Additionally, a categorical evaluation with a responder analysis will be evaluated, including the proportion of patients who maintain vision (< ETDRS 15L loss), the proportion of patients who gain 15 ETDRS letters from baseline and the proportion of patients with Snellen acuity of >20/200. Complementary vision metrics will include automated visual fields, optical coherence tomography, and color and contrast sensitivity, in addition to quality of life scales, biodissemination and the time course of immune response. Readouts for these endpoints are at 48, 72 and 96 weeks after injection.

The trials are conducted in parallel, in 37 subjects for REVERSE and 39 subjects for RESCUE, in 7 centers across the United States, the UK, France, Germany and Italy. Week 96 results were reported in 2019 for both trials, after which patients were transferred to a long-term follow-up study that will last for three years.

ClinicalTrials.gov Identifiers:REVERSE: NCT02652780RESCUE: NCT02652767

View source version on businesswire.com: https://www.businesswire.com/news/home/20200302005891/en/

Contacts

GenSight Biologics Thomas GidoinChief Financial Officertgidoin@gensight-biologics.com +33 (0)1 76 21 72 20

RooneyPartners Media RelationsMarion Janicmjanic@rooneyco.com +1-212-223-4017

LifeSci Advisors Investor RelationsGuillaume van Renterghemgvanrenterghem@lifesciadvisors.com +33 (0)6 69 99 37 83

James Palmer Retail Investorsj.palmer@orpheonfinance.com +33 (0) 7 60 92 77 74

Read more from the original source:
GenSight Biologics Announces Presentation of Bilateral Visual Recovery From GS010 (LUMEVOQ) Phase III Trials at the 46th Annual Meeting of NANOS -...

Weak eyesight is a common thing these days. People today are staring into screens for hours at a stretch. The prolonged exposure to the rays emitted by laptop/ mobile phone screens results in weak eyesight. However, screens are not the only nemesis the human eye has to fight. There are undoubtedly other factors such as age, genes, and premature birth, etc. 8 million people around the world have a refractive error.

Refractive error is an ailment where the eye has a hard time focusing the light on the retina, further leading to an inaccurate vision. This is a result of distorted eye shape. Common refractive errors include near-sightedness, astigmatism, presbyopia, and far-sightedness.

The traditional treatment for refractive error is wearing spectacles and contact lenses. However, a lot has changed now! Gone are those days where humans would make do with large glass frames or irritating lenses; the modern solution seems to be in LASIK surgery!

The sigh of relief came with the approval of LASIK surgery in 1999. Back in the early 90s, people were apprehensive about getting it done since it was a less explored field of medicine. However, now LASIK surgery is the go-to option for a lot of people.

Over 30 million people opted for LASIK surgery in the year 2017. No wonder, LASIK surgery has got its audience now, and is soon becoming a more popular treatment for refractive eye disorders! However, lets see if the procedure is genuine, all that wonderful!

Is LASIK worth it?

A typical LASIK procedure takes about 20 minutes, and the patient, in most cases, would be able to resume their life as it was within three days from the surgery. LASIK means Laser-Assisted in Situ Keratomileusis.

This procedure involves the change in the shape of the eye. The operation is done with a laser and is one of the most accurate methods to correct the vision. A few reasons to opt for LASIK surgery for correction are:

Are there any risks involved?

The shape of the eyes keeps changing with age. Therefore, like every other medical procedure, LASIK has its drawbacks. However, these drawbacks arent something that cant be corrected with care.

What should one look for when opting for the LASIK procedure?

Since a persons eyes are at stake, they should be extra careful while zeroing down on the facility where theyd like to have their procedure done. At this point, a persons instincts will come to play.

Key takeaway

LASIK surgery is a delicate procedure that needs to be performed with care. Significant measures are taken to ensure that the surgery is neat and sanitary. Since it involves your eyes, you should take the utmost care while selecting their surgeons. A lot of people prefer a specs-free look, and LASIK makes that dream come true.

See original here:
Is LASIK Surgery Worth The Money? Know All About It - Scubby

A brain tumour is a growth of cells in the brain that multiplies in an abnormal, uncontrollable way. Brain tumours are graded according to how fast they grow and how likely they are to grow back after treatment. The grading also determines when you may experience symptoms and their level of acuteness.

In addition, you may find that your eyesight is generally getting worse and glasses are not helping, or your vision comes and goes, says the charity.

Other eye-related symptoms include:

According to the NHS, you should see a GP if you have these types of symptoms, particularly if you have a headache that feels different from the type of headache you usually get, or if headaches are getting worse.

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As the health body points out, you may not have a brain tumour, but these types of symptoms should be checked.

If your GP cannot identify a more likely cause of your symptoms, they may refer you to a doctor who specialises in the brain and nervous system (neurologist) for further assessment and tests, such as a brain scan, adds the health site.

The cause of most brain tumours is unknown, but there are several risk factors which may increase your chances of developing a brain tumour.

According to Cancer Research UK, one risk factor you cannot change is age. Although brain tumours can start at any age, the risk increases as you get older.

The risk of brain tumours is greatest in those aged between 85 and 89 years, says the charity.

Another unchangeable risk factor is family history and genetic conditions - some genetic conditions are known to increase the risk of getting a brain tumour, including tuberous sclerosis, neurofibromatosis type 1, neurofibromatosis type 2 and Turner syndrome, explains the NHS.

There are steps you can take to reduce your risk, however, such as maintaining a healthy weight.

Being overweight or obese increases the risk of some cancer types, including a type of brain tumour called meningioma, explains Cancer Research UK.

Read more from the original source:
Brain tumour symptoms: The sign in your vision that could signal the cancer - Express

(PRESS RELEASE) RightEye LLC revealed the six finalists of its 2020 RightEye Impact Awards. This program was created to recognize, honor and celebrate the many unsung accomplishments of healthcare providers worldwide who are transforming peoples lives through measuring and treating functional vision health. RightEye is an eye movement biomarker company using eye-tracking technology to revolutionize health care and to help more accurately identify health and vision issues. The RightEye Impact Awards received submissions from across the United States as well as from Australia, the Netherlands, Albania and Canada. The grand prize winner will be honored at a ceremony on March 13 in the winners hometown.

The finalists were judged based on the magnitude of clinical progress and the patients improved quality of life. Each provider used RightEye in some way to enable progress, including communicating dysfunction, validating problems, providing solutions, and changing the mindset of patients and families by demonstrating treatment progress. Award applicants used a variety of RightEye tests including Brain Health, Reading, and Functional Vision as well as RightEyes EyeQ Trainer for improving oculomotor dysfunction.

RightEye is helping to improve lives for those affected by many different kinds of issues, such as concussion, dyslexia, Parkinsons, learning disabilities, and more, said RightEye CEO Adam Gross. At the same time, we are providing healthcare providers with a groundbreaking, FDA-cleared tool to help them improve patient care while expanding their practices.

Many people impacted by these problems may never realize that eye movement testing and treatments that address visual/brain processing can actually make a huge difference for them. Thats why we are shining a light on the most inspirational stories weve heard from our customers. Narrowing the field down to six finalists was more difficult than we expected because so many of the stories were absolutely incredible.

The finalists are:

1. Dr. Sally Fryer Dietz, Integrative Concussion & Pediatric Therapy, Dallas, TXA 13-year-young woman was diagnosed with dyslexia and had been receiving remedial work outside of the clinic. After a RightEye assessment and sensory motor evaluation, Dietz realized the patient was actually not dyslexic and the problem was more related to a visual tracking issue and SI Dysfunction. Following treatment, her scores went up dramatically to several grade levels above where she had initially tested. The patients self-esteem and confidence skyrocketed, along with her ability to memorize scripts and read advanced level books.

2. Debra Holtzhauer, Listowel Vision Care, Listowel, Ontario, CanadaA 34-year-old female patient was kicked in the head and her resulting concussion left her with persistent pain and vision issues that impacted her ability to sew, cook, drive, read, etc. After a RightEye test and vision therapy, all symptoms were eliminated or greatly reduced. Pain meds were no longer needed and she was able to resume her daily activities.

3. Jeremiah Jorgensen, Fyzical Therapy and Balance Centers, Lincoln, NEA 7-year-old child was diagnosed with a learning disability and was receiving occupational therapy, physical therapy and speech therapy. After a RightEye test it became clear that a vision issue made it difficult to read and limited her depth perception. Within six weeks of treatment, her spelling and reading tests put her at or near the top of her class, and three months later she rode a bike for the first time in her life. Due to RightEye we not only changed a childs life but her father was in tears for helping him enjoy time with his daughter as she can now enjoy childhood tasks and games that most parents take for granted.

4. Dr. Amanda Nanasy, Florida Institute of Sports Vision at The Eye Center, Pembroke Pines, FLA college-aged patient had suffered a concussion from a motor vehicle accident and had been under the care of a concussion rehab doctor who did not utilize visual treatment or care. The patient wore glasses and walked with a lean to the side due to poor fixation. Following RightEye testing and prescription of new prisms, he no longer needed glasses, and his lean disappeared.

5. Dr. Neil Renaud, EagleEye Performance Vision, Holland, MIAn 11-year-old patient was struggling with schoolwork, experiencing blurry and double vision, as well as attention issues, poor comprehension, clumsiness and poor handwriting. He was preparing to end his education at the high school level and embark on a blue-collar career that didnt require reading. Following a RightEye test, Renaud diagnosed oculomotor dysfunction of pursuits, saccades, and fixations. After completion of vision therapy, the patients performance in reading, handwriting, and ability to pay attention improved drastically and blurry and double vision became non-existent. He now plans to go to college to become an optometrist.

6. Dr. Gregory Schultz, Eye Center of Virginia, Williamsburg, VAA CEO of a growing company suffered a concussion after hitting her head on a concrete floor. Symptoms included extreme dizziness, unsteady gait, headaches, confusion, memory issues and delayed reaction time, along with reading ability now at a fourth-grade level. She was told by a neurologist the symptoms would be temporary but she saw no improvement after several months. Following a RightEye test she was diagnosed with multiple deficiencies in horizontal tracking, fixations, horizontal saccades and visual recognition and reaction time. After four months of treatment with RightEyes EyeQ Trainer, the patient has experienced improvements in tracking, saccades and fixations, with corresponding improvements in function.

Link:
Record Attendance Reported for IDOC's 2020 National Conference - InvisionMag