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Leronlimab Used in Seven Patients with Severe COVID-19 Demonstrated Promise with Two Intubated Patients in ICU, Removed from ICU and Extubated with…

March 30th, 2020 5:47 am

VANCOUVER, Washington, March 27, 2020 (GLOBE NEWSWIRE) -- CytoDyn Inc. (OTC.QB: CYDY), (CytoDyn or the Company"), a late-stage biotechnology company developing leronlimab (PRO 140), a CCR5 antagonist with the potential for multiple therapeutic indications, announced today the three-day results post-leronlimab treatment of the first four patients under an Emergency Investigational New Drug (EIND) granted by the U.S. Food and Drug Administration (FDA). A total of seven patients have been enrolled thus far under EIND in the same leading medical center in the New York City area.

The treatment with leronlimab is targeted as a therapy for patients who experience respiratory complications as a result of contracting SARS-CoV-2 causing the Coronavirus Disease 2019 (COVID-19). Leronlimab is believed to provide therapeutic benefit by enhancing the immune response while mitigating the cytokine storm that leads to morbidity and mortality in these patients.

Bruce Patterson, M.D., Chief Executive Officer and founder of IncellDx, a diagnostic partner and advisor to CytoDyn, said, IncellDx has developed specific companion diagnostic tests to determine the efficacy and dosing of leronlimab in these severe cases of COVID-19. We found that patients with severe COVID-19 disease are in the midst of immunologic chaos which includes the cytokine storm. Our companion diagnostics showed that after three days of therapy, the immune profile in these patients approached normal levels and the levels of cytokines involved in the cytokine storm were much improved.

Jacob Lalezari, M.D., Interim Chief Medical Officer of CytoDyn, commented, These preliminary results give hope that leronlimab may help hospitalized patients with COVID-19 recover from the pulmonary inflammation that drives mortality and the need for ventilators. A leading medical center in the heart of the New York City epidemic was instrumental in giving the preliminary data.

Nader Pourhassan, Ph.D., President and Chief Executive Officer of CytoDyn said: We are extremely pleased for the coronavirus patients under the care of the treating medical team and that the FDA is so responsive to advance our Phase 2 clinical trial. I am very hopeful that leronlimab can help to reduce the rate of mortality among COVID-19 patients with severe symptoms of ARDS and to assist our government to fight this battle.

About Coronavirus Disease 2019SARS-CoV-2 was identified as the cause of an outbreak of respiratory illness first detected in Wuhan, China. The origin of SARS-CoV-2 causing the COVID-19 disease is uncertain, and the virus is highly contagious. COVID-19 typically transmits person to person through respiratory droplets, commonly resulting from coughing, sneezing, and close personal contact. Coronaviruses are a large family of viruses, some causing illness in people and others that circulate among animals. For confirmed COVID-19 infections, symptoms have included fever, cough, and shortness of breath. The symptoms of COVID-19 may appear in as few as two days or as long as 14 days after exposure. Clinical manifestations in patients have ranged from non-existent to severe and fatal. At this time, there are minimal treatment options for COVID-19.

About Leronlimab (PRO 140) The FDA has granted a Fast Track designation to CytoDyn for two potential indications of leronlimab for deadly diseases. The first as a combination therapy with HAART for HIV-infected patients and the second is for metastatic triple-negative breast cancer.Leronlimab is an investigational humanized IgG4 mAb that blocks CCR5, a cellular receptor that is important in HIV infection, tumor metastases, and other diseases, including NASH.Leronlimab has completed nine clinical trials in over 800 people, including meeting its primary endpoints in a pivotal Phase 3 trial (leronlimab in combination with standard antiretroviral therapies in HIV-infected treatment-experienced patients).

In the setting of HIV/AIDS, leronlimab is a viral-entry inhibitor; it masks CCR5, thus protecting healthy T cells from viral infection by blocking the predominant HIV (R5) subtype from entering those cells. Leronlimab has been the subject of nine clinical trials, each of which demonstrated that leronlimab could significantly reduce or control HIV viral load in humans. The leronlimab antibody appears to be a powerful antiviral agent leading to potentially fewer side effects and less frequent dosing requirements compared with daily drug therapies currently in use.

In the setting of cancer, research has shown that CCR5 may play a role in tumor invasion, metastases, and tumor microenvironment control. Increased CCR5 expression is an indicator of disease status in several cancers. Published studies have shown that blocking CCR5 can reduce tumor metastases in laboratory and animal models of aggressive breast and prostate cancer. Leronlimab reduced human breast cancer metastasis by more than 98% in a murine xenograft model. CytoDyn is, therefore, conducting aPhase 1b/2 human clinical trial in metastatic triple-negative breast cancer and was granted Fast Track designation in May 2019.

The CCR5 receptor appears to play a central role in modulating immune cell trafficking to sites of inflammation. It may be crucial in the development of acute graft-versus-host disease (GvHD) and other inflammatory conditions. Clinical studies by others further support the concept that blocking CCR5 using a chemical inhibitor can reduce the clinical impact of acute GvHD without significantly affecting the engraftment of transplanted bone marrow stem cells. CytoDyn is currently conducting a Phase 2 clinical study with leronlimab to support further the concept that the CCR5 receptor on engrafted cells is critical for the development of acute GvHD, blocking the CCR5 receptor from recognizing specific immune signaling molecules is a viable approach to mitigating acute GvHD. The FDA has granted orphan drug designation to leronlimab for the prevention of GvHD.

About CytoDynCytoDyn is a late-stage biotechnology company developing innovative treatments for multiple therapeutic indications based on leronlimab, a novel humanized monoclonal antibody targeting the CCR5 receptor. CCR5 appears to play a critical role in the ability of HIV to enter and infect healthy T-cells.The CCR5 receptor also appears to be implicated in tumor metastasis and immune-mediated illnesses, such as GvHD and NASH. CytoDyn has successfully completed a Phase 3 pivotal trial with leronlimab in combination with standard antiretroviral therapies in HIV-infected treatment-experienced patients. CytoDyn plans to seek FDA approval for leronlimab in combination therapy and plans to complete the filing of a Biologics License Application (BLA) in the first quarter of 2020 for that indication. CytoDyn is also conducting a Phase 3 investigative trial with leronlimab as a once-weekly monotherapy for HIV-infected patients. CytoDyn plans to initiate a registration-directed study of leronlimab monotherapy indication. If successful, it could support a label extension. Clinical results to date from multiple trials have shown that leronlimab can significantly reduce viral burden in people infected with HIV with no reported drug-related serious adverse events (SAEs). Moreover, a Phase 2b clinical trial demonstrated that leronlimab monotherapy can prevent viral escape in HIV-infected patients; some patients on leronlimab monotherapy have remained virally suppressed for more than five years. CytoDyn is also conducting a Phase 2 trial to evaluate leronlimab for the prevention of GvHD and a Phase 1b/2 clinical trial with leronlimab in metastatic triple-negative breast cancer. More information is atwww.cytodyn.com.

Forward-Looking StatementsThis press releasecontains certain forward-looking statements that involve risks, uncertainties and assumptions that are difficult to predict. Words and expressions reflecting optimism, satisfaction or disappointment with current prospects, as well as words such as believes, hopes, intends, estimates, expects, projects, plans, anticipates and variations thereof, or the use of future tense, identify forward-looking statements, but their absence does not mean that a statement is not forward-looking. The Companys forward-looking statements are not guarantees of performance, and actual results could vary materially from those contained in or expressed by such statements due to risks and uncertainties including: (i)the sufficiency of the Companys cash position, (ii)the Companys ability to raise additional capital to fund its operations, (iii) the Companys ability to meet its debt obligations, if any, (iv)the Companys ability to enter into partnership or licensing arrangements with third parties, (v)the Companys ability to identify patients to enroll in its clinical trials in a timely fashion, (vi)the Companys ability to achieve approval of a marketable product, (vii)the design, implementation and conduct of the Companys clinical trials, (viii)the results of the Companys clinical trials, including the possibility of unfavorable clinical trial results, (ix)the market for, and marketability of, any product that is approved, (x)the existence or development of vaccines, drugs, or other treatments that are viewed by medical professionals or patients as superior to the Companys products, (xi)regulatory initiatives, compliance with governmental regulations and the regulatory approval process, (xii)general economic and business conditions, (xiii)changes in foreign, political, and social conditions, and (xiv)various other matters, many of which are beyond the Companys control. The Company urges investors to consider specifically the various risk factors identified in its most recent Form10-K, and any risk factors or cautionary statements included in any subsequent Form10-Q or Form8-K, filed with the Securities and Exchange Commission. Except as required by law, the Company does not undertake any responsibility to update any forward-looking statements to take into account events or circumstances that occur after the date of this press release.

CYTODYN CONTACTSInvestors: Dave Gentry, CEORedChip CompaniesOffice: 1.800.RED.CHIP (733.2447)Cell: 407.491.4498dave@redchip.com

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Multiple Sclerosis and Russian Treatments

March 30th, 2020 5:46 am

Do you have any desire to travel to Russia?

You might if you have multiple sclerosis.

People with multiple sclerosis (MS) in the United States and Canada are traveling to Russia for an experimental treatment thats a potential cure for the disease.

However, there are still a number of risks involved.

Hematopoietic Stem Cell Transplantation (HSCT) is a therapy for MS that has, in many cases, been shown to halt progression of the disease with a single treatment.

However, in North America, the procedure is still considered experimental and isnt widely available. Its also costly.

For individuals facing a potential lifetime of MS, the allure of a cure abroad is tantalizing.

According to Bruce Bebo, executive vice president of research at the National Multiple Sclerosis Society, HSCT treatment is promising. But he cautions there still arent enough rigorous clinical studies on it to weigh the real risks and benefits.

MS is a demyelinating autoimmune disease in which the bodys immune system begins to attack the myelin, the protective insulation of the nervous system.

These attacks cause scarring (sclerosis) that leads to a host of neurological symptoms from tremors and loss of vision, to difficulty with speech.

Its typically diagnosed in individuals between the ages of 20 and 40.

HSCT is a complex procedure that requires a bone marrow transplant similar to that used by oncologists for certain blood cancers.

The treatment is an attempt to reboot the immune system and stop it from attacking the brain and spinal cord.

One way to think about it is that you are reeducating and creating a new immune system, Bebo told Healthline. It appears that in many cases when you do this, that new immune system learns that the central nervous system isnt dangerous anymore and it doesnt attack it anymore.

In the first step of HSCT treatment, chemotherapy is used to stimulate the production of bone marrow stem cells and promote their release into the bloodstream. This blood is then drawn and stored.

The patient is then given a strong dose of more chemotherapy, most often in a hospital setting, for up to 11 days.

During that time, immune cells are either dramatically weakened or killed entirely.

Finally, the patients stored stem cells are infused back into the body, learning to leave the nervous system intact.

The process can be strenuous.

Patients must take antibiotics to fight off infections while their immune systems are suppressed.

They must also stay in the hospital for weeks at a time while their immune system rebuilds.

A recent study said that the average hospital stay after the stem cell infusion lasted between 10 and 160 days.

That may be a small price to pay to stop a chronic illness, especially for individuals diagnosed young.

Theres also the matter of the real price as in dollars.

I think [the reason] people are leaving the country has to do with cost, said Bebo. Im aware of many people who although they have to fight tooth and nail to get it, can get their insurance company to cover most or all the costs of this procedure in the U.S. Its expensive.

The cost is in the six-figure range. Healthline previously reported that it could be done in the United States for about $125,000.

Its a lot cheaper to go to Mexico or Russia to get HSCT therapy, where they will perform the therapy for a fraction of the cost, said Bebo.

There are also caveats to the treatment, dependent on the MS diagnosis.

Broadly speaking, there are two major types of MS: relapsing and progressive.

Relapsing, the more common form, is identified by intermittent attacks or exacerbations in which symptoms will worsen for a period and then dissipate.

As the disease progresses, the exacerbations get worse and the overall disability of the person increases.

Bebo describes progressive MS as a slow, steady progression of disability. Its less common but significantly more difficult to treat.

What little evidence we have at this point suggests that people with progressive MS dont respond to HSCT, said Bebo.

Typical drug regimens for relapsing MS, called disease modifying therapies (DMTs), also tend to be less effective for progressive MS.

This gap, as Bebo puts it, in treatment between progressive and relapsing MS may be driving medical tourism abroad.

Against doctors recommendations, patients may still elect to travel abroad to seek out HSCT for progressive MS.

New drugs, such as Ocrevus (ocrelizumab), have been approved more recently by the FDA for the treatment of progressive MS.

HSCT treatment isnt without risks.

Its not a trivial procedure and has been known for its serious mortality risk.

A study from 2017 concluded that while the procedure showed significant benefit against MS progression, the overall transplant-related mortality rate was about 2 percent.

As the procedure has improved, so have mortality rates. An older 2002 study of 85 MS patients treated with HSCT documented seven deaths in the group a mortality rate of about 8 percent.

I think there are still many neurologists who remember the older studies, the high risk of mortality, said Bebo, and until there is a rigorous, well-controlled study that documents the effectiveness and mortality risk, then I think some neurologists are going to be hesitant to recommend the therapy.

But Bebo and his colleagues at the MS society are also enthusiastic about the growing interest and research being done on HSCT.

I do see the neurology community being more accepting of this approach than they have in the past.

However, he emphasizes that HSCT isnt an MS panacea.

Depending on the diagnosis, the procedure must find its way into established therapy methods.

While HSCT is available in the United States today, it could still be years before its easily accessible and affordable.

We really look forward to the day when we have results from a really well-controlled, rigorous clinical trial to really tell us once and for all whats the full benefit of this, what are the full risks, and who is the person most likely to benefit from it, said Bebo.

Until then, people living with MS may choose to seek out treatment abroad, where the chance at a permanent cure may already be available.

In the race against a chronic illness, the U.S. medical system may just be moving too slowly for the young and the desperate.

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Multiple Sclerosis and Russian Treatments

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Stem-Cell Craze Spreads in Russia | WIRED

March 30th, 2020 5:46 am

MOSCOW While scientists worldwide are only studying stem cells, dozens of Russian clinics and beauty salons claim they are already using both adult and embryonic stem cells to treat everything from wrinkles to Parkinson's disease to impotence.

Scientists warn that while stem cells are still being researched in laboratories, treatment by clinics claiming to use stem cells may cost patients their health and fortunes. Moreover, they say, even though it's illegal, enforcement is lax and no one knows if the injections patients are getting contain stem cells.

When Svetlana Galiyeva found a clinic offering to treat her multiple sclerosis with embryonic stem cells, she grabbed the opportunity. Twenty-thousand dollars later she is still in a wheelchair and desperate. And there is no proof her injections had anything to do with stem cells.

Stem cells are the building blocks of the human body immature cells that can grow into bone, muscle and other tissues. They are plentiful in the embryo and fetus and are believed to be more versatile than stem cells from adult bone marrow and fat. But embryonic stem cells are controversial because they involve destruction of human embryos.

In leading clinics around the world, most stem-cell research is limited to the lab dish and animals. In Russia, however, it's a different story.

Galiyeva, a 40-year-old gynecologist in the Ural Mountains city of Perm, developed multiple sclerosis nine years ago. She gradually lost control over her muscles and was enduring nearly constant muscle spasms, leaving doctors pessimistic about her ability to recuperate.

"I understood what was awaiting me. It was either death or ...," Galiyeva said by telephone from Perm.

Driven to despair, Galiyeva traveled to a Moscow clinic for a series of injections that her doctors said were embryonic stem cells, costing her about $20,000 a huge sum in a country where the average monthly salary equals about $300.

Initially, her body nearly rejected the treatment with a 104 degree fever. Her limbs then regained some sensation, but that didn't last.

"Continuing that treatment was useless," she said bitterly.

Things didn't end there. She says her condition has improved after a new series of injections, said to contain adult stem cells, at Beauty Plaza, a private clinic in Moscow that advertises stem-cell treatments for a variety of diseases. She still cannot walk, but can stand unaided for brief periods, she said.

Meanwhile, hundreds of patients are rushing to Russian clinics and beauty salons that claim to offer embryonic stem-cell therapy for a range of diseases as well as cosmetic therapy.

Dr. Roman Knyazev's Cellulite, a clinic in central Moscow, advertises injections of stem cells from aborted fetuses into thighs, buttocks and stomachs to help women get rid of cellulite and look younger.

Yelena, a 37-year-old Moscow entrepreneur, says they worked for her. "After giving birth my belly was hanging like a rag and I had lots of stretch marks. Now it's all gone," she said after shelling out $2,850 for injections at Knyazev's clinic. She declined to give her last name.

But experts say the procedure carries potentially dangerous side effects.

"No one has been given any licenses for injecting (stem cells) these are only experiments. This is all being done at their own risk. This is all illegal," said Vladimir Smirnov, director of the Institute of Experimental Cardiology, who runs an adult stem-cell bank.

He said he knew of several state research institutes attempting occasional experimental treatment using adult stem cells from bone marrow and fat. Many other clinics, however, run with little regulation as to what they advertise and inject, Smirnov said.

Scientists say cultivating and isolating stem cells requires skill and expensive equipment that the clinics do not necessarily have. Therefore, what is claimed to be stem cells may be anything from a fetal tissue extract to skin cells. Some clinics reportedly use animal stem cells.

"If I was a patient, I wouldn't want that to be done on me.... The risks are potentially very high," said Joshua Hare, director of the cardiovascular section at the Johns Hopkins Institute for Cell Engineering in Baltimore.

Andrei Yuriyev, deputy head of the Federal Health Care Inspection Service, said the law permits only extraction and storage of stem cells not their use in treatment. Yuriyev said his service is investigating nearly 20 cosmetic clinics that claim to practice stem-cell therapy.

But with such vaguely defined regulations, dozens of clinics continue operating.

Dr. Alexander Teplyashin, head of Beauty Plaza, says he has used adult stem cells from patients' or donors' fat and bone marrow to treat diabetes, vision disorders and other diseases. He acknowledges that what he's doing is technically not permitted.

"We are taking advantage of the loopholes in the law ... what is not forbidden is allowed," he told The Associated Press at his clinic in downtown Moscow.

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Global Myocardial Fibrosis Market Insights, Forecasts to 2026 : Merck, Evotec AG, Miragen Therapeutics, TRACON Pharmaceuticals – Global Industry News…

March 30th, 2020 5:46 am

Global Myocardial Fibrosis Market 2020 provides in-depth analysis of the current and upcoming market and synopsis of product type, specification, product innovation, and production analysis considering major key factors, like Cost, Revenue, Gross, and Gross Margin and provides the entirely analysis of Myocardial Fibrosis Market using manufacturing process, price analysis and SWOT analysis (Strength, Weakness, Opportunities, and Threat) is examined in this study report.

This market understand repository presents readers with an encyclopedic evaluation of the global Myocardial Fibrosis market. Each aspect of the global Myocardial Fibrosis market is assessed in thorough detail in the report to provide a 360-degree review of the markets workings for interested parties. The past, present, and future growth trajectory of the Myocardial Fibrosis Market are assessed in the report, with detailed analysis of the historical trajectory of the market providing a solid database for reliable predictions regarding the Myocardial Fibrosis Market future.

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Company Coverage (Company Profile, Sales Revenue, Price, Gross Margin, Main Products, etc.): Merck, Evotec AG, Miragen Therapeutics, TRACON Pharmaceuticals, Daewoong Pharmaceutical, Galectin Therapeutics GTx, Invivosciences, Lead Discovery Center, MandalMed

Segmentation By Product Type and analysis of the Myocardial Fibrosis Market:Small Molecule Therapeutic Modality, Protein Therapeutic Modality, Peptide Therapeutic Modality, Endoglin Antibody Therapeutic Modality, Stem Cell Therapeutic Modality, Rna Therapeutic Modality, Other

Segmentation By Application and analysis of the Myocardial Fibrosis Market:Hospital, Clinics, Research Laboratories

Overview of the Report: The report begins with a market overview and moves on to cover the growth prospects of the markets. Global Myocardial Fibrosis industry 2020 is a comprehensive, professional report delivering market research data that is relevant for new market entrants or established players. Key methodologies of the organizations working in the business sectors and their effect included for the report. Moreover, the main player's revenue share, business overview, and analysis in the Myocardial Fibrosis market are available in the report.

Do You Have Any Query Or Specific Requirement? Ask Our Industry Expert: https://www.syndicatemarketresearch.com/inquiry/myocardial-fibrosis-market

Geographical Segmentation And Analysis Of The Myocardial Fibrosis Market

Regionally, the market is divided into North America, Latin America, Europe, Asia Pacific, and the Middle East and Africa. In which North America ruled the global Myocardial Fibrosis market in 2019.

North America (USA, Canada, & Mexico)South America (Brazil, Argentina)Asia-Pacific (China, Japan, Korea, India, Indonesia, & Australia)Europe (Turkey, Germany, Russia, UK, Italy, France)The Middle East and Africa (GCC Countries & Egypt)and the rest countries of each region

Key Questions Answered In The Report Include:

What will the growth rate and market size be in 2026?What are the key factors driving the global Myocardial Fibrosis market?What are the key market trends impacting the growth of the global Myocardial Fibrosis market?What are the challenges to market growth?Who are the key vendors in the global Myocardial Fibrosis market?What are the market opportunities and threats faced by the vendors in the global Myocardial Fibrosis market?Growing factors affecting the market shares of the EMEA, Americas, and APAC.What are the key outcomes of the five forces analysis of the global Myocardial Fibrosis market?

What the Report has in Store for you?

Industry Size & Forecast: The industry analysts have offered historical, current, and estimated projections of the industry size from the value and volume point of view

Future Opportunities: In this section of the report, Myocardial Fibrosis participants are provided with the information on the future prospects that the Myocardial Fibrosis industry is likely to offer

Industry Trends & Developments: Here, authors of the report have talked about the major trends and developments taking place in the Myocardial Fibrosis marketplace and their estimated impact on the overall growth

Study on Industry Segmentation: Detailed breakdown of the key Myocardial Fibrosis industry segments including product type, application, and vertical has been done in this portion of the report

Regional Analysis: Myocardial Fibrosis vendors are offered crucial information about the high growth regions and their respective countries, thus helping them to invest in profitable regions

Competitive Landscape: This unit of the report throws light on the competitive scenario of the Myocardial Fibrosis industry by focusing on the key strategies taken up by the vendors to consolidate their presence in the Myocardial Fibrosis business.

The study report includes the following chapters:

Chapter 1, describe market overview, market opportunities, market driving force, market risks, and Myocardial Fibrosis product scopeChapter 2, profile the top manufacturers of Myocardial Fibrosis, with sales, revenue, price, and global market share of Myocardial Fibrosis in 2019 and 2020Chapter 3, the Myocardial Fibrosis competitive situation, sales, revenue and global market share of leading manufacturers are analyzed decisively by landscape contrastChapter 4, the Myocardial Fibrosis breakdown data are shown at the regional level, to show the sales, revenue, and growth by regions, from 2020 to 2025Chapters 5, 6, 7, 8 and 9, to break the sales data at the country level, with sales, revenue, and market share for key countries in the world, from 2020 to 2026Chapters 10 and 11, to segment the sales by type and application, with sales market share and growth rate by type, application, from 2020 to 2026Chapter 12, Myocardial Fibrosis market forecast, by regions, type, and application, with sales and revenue, from 2020 to 2026Chapter 13, 14 and 15, to describe Myocardial Fibrosis sales channel, distributors, customers, research findings and conclusion, appendix and data source

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Global Myocardial Fibrosis Market Insights, Forecasts to 2026 : Merck, Evotec AG, Miragen Therapeutics, TRACON Pharmaceuticals - Global Industry News...

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Global Cell Culture Market 2020 Valuable Growth Prospects and Upcoming Trends till 2025 – The Fuel Fox

March 30th, 2020 5:46 am

The latest report entitled Global Cell Culture Market Growth 2019-2024 provides a detailed evaluation of the business vertical which contains a detailed evaluation of the business vertical. An exceptionally workable estimation of the present industry scenario has been delivered in the report, highlighting regional market scope, product-market various applications, market size according to a specific product, sales and revenue by region, manufacturing cost analysis, industrial chain, market effect factors analysis, market size forecast for 2020 to 2025 time-period, and more. The report discusses industry top manufacturers along with their companys profiles, financial analysis, overview, market revenue, by geographical regions.

Top companies in the global Cell Culture market: Thermo Fisher , PromoCell , Merck Millipore , GE Healthcare , BD , Corning , HiMedia , Takara , CellGenix , Lonza , ,

On the basis of region, the market is categorized into the following regions: Americas (United States, Canada, Mexico, Brazil), APAC (China, Japan, Korea, Southeast Asia, India, Australia), Europe (Germany, France, UK, Italy, Russia, Spain), Middle East & Africa (Egypt, South Africa, Israel, Turkey, GCC Countries)

DOWNLOAD FREE SAMPLE REPORT: https://marketandresearch.biz/sample-request/99495

The research study demonstrates a complete view of the global Cell Culture market by diversifying it in terms of product type, application, and region. Moreover, the report revises the market share held by the key players and forecast their development in the upcoming years. It offers a better understanding of the market competitors, key trends, product innovations, market size value/volume (regional/country level, industry segments), and market share of top players/products. A comprehensive analysis of the market dynamics that is all-inclusive of market drivers, restraints, and opportunities is part of the report.

Market segment by type covers: Classical Media & Salts , Serum-free Media , Stem Cell Media , Others , ,

Market segment by applications can be divided into: Biopharmaceutical Manufacturing , Tissue Culture & Engineering , Gene Therapy , Other , ,

Further analysts have analyzed the production and consumption of the market. Here the analysis of the production, revenue, gross margin of its main manufacturers and the unit price with respect to production has been presented. With respect to consumption, the report analyzes the consumption volume, consumption value, sale price, import and export in different regions from 2014 to 2020. The study also gives a prediction of its production and consumption in the coming 2020-2025. Additionally, down, upcoming advancements and changes in the global Cell Culture are further expected to fuel the growth of the global market during the forecast period of 2020-2025.

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Here Are Some Key Takeaways From The Global Cell Culture Report:

Customization of the Report:This report can be customized to meet the clients requirements. Please connect with our sales team ([emailprotected]), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on +1-201-465-4211 to share your research requirements.

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Global Cell Culture Market 2020 Valuable Growth Prospects and Upcoming Trends till 2025 - The Fuel Fox

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Cell Sorting Market 2020 to Witness Exponential Growth. Top Growing Companies are Breathalyzers, Akers Biosciences Inc., Alcohol Countermeasure…

March 30th, 2020 5:46 am

In this Cell Sorting market report, breakdown and estimations of important industry trends, market drivers, market restraints, market size, market share and sales volume have been explained very well. This global market report gives CAGR value fluctuation during the forecast period of 2020-2027 for the Healthcare industry that helps in estimating investment and costing. To take decisions of growing or lessening the production of goods depending on the general market conditions and demand, plentiful information accompanied with deep Cell Sorting market insights plays a supportive role. Most recent and established tools and techniques are utilized exceptionally to make the report outstanding.

Cell sorting market is expected to experience market growth at a rate of 7.87% in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market to account to USD 502.27 million by 2027. Due to the wide-scale acceptance of cell sorting techniques as a method of increasing the understanding of tissues and cell samples, market players have developed specialized reagents designed for each individual application of cell sorting methods.

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The major players covered in the Cell Sorting Market report are Abcam plc, Sepmag, BD, Beckman Coulter, Inc., Bio-Rad Laboratories, Inc., Sony Biotechnology Inc., Miltenyi Biotec, Thermo Fisher Scientific Inc., Sysmex Partec GmbH, On-chip Biotechnologies. Co., Ltd., Cytonome/ST, LLC, Union Biometrica, Inc., Luminex Corporation, pluriSelect Life Science UG (haftungsbeschrnkt) & Co. KG, STEMCELL Technologies Inc., TERUMO BCT, INC., Cellular Highways, Abgenex, among other players domestic and global. Market Share data is available for Global, North America, Europe, Asia-Pacific, Middle East & Africa and South America separately. DBMR analysts understand competitive strengths and provide competitive analysis for each competitor separately.

Market Analysis and Insights:Global Cell Sorting Market

In February of 2019, Institute of Life Sciences announced that they had developed a modernized magnetic cell separation kit designed for its application in various research-based and medical applications. This kit termed as QuikSort has been developed to improve the cost-effectiveness of the cell sorting instruments and kits currently commercialized in the market where Abgenex will be responsible for its commercialization. The kit has been based on the patented technology and will be responsible for the separation of only specific cells

Cell sorting is defined as that technology field which enables isolation of cells from the tissue sample based on their type. This technology invokes differentiation of cells based on the different size, shape, surface protein expression amongst various others. This technology results in the growth of these cells in a clump that does not consist of any adhesion.

There has been a renewed level of focus from the healthcare industry on furthering their understanding of human tissues and cells, this focus has essentially given rise to an increased level of consumption for different varieties of research based products, solutions and technologies consisting of cell sorting techniques of research. Along with the growing volume of research activities, the significant growth witnessed by the pharmaceutical and biotechnology organizations resulting in enhanced consumption rate for research based products and solutions are all factors expected to drive the growth of cell sorting market in the forecast period of 2020 to 2027.

This market report provides details of market share, new developments, product pipeline analysis, impact of domestic and localised market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, product approvals, strategic decisions, product launches, geographic expansions, technological innovations in the market. To understand the analysis and the market scenario contact us for anAnalyst Briefour team will help you create a revenue impact solution to achieve your desired goal.

Global Cell Sorting Market Scope and Market Size

Cell sorting market is segmented on the basis of technology, product & service, application and end user. Each individual segments growth is analysed and these insights are subsequently considered before providing you with the market overview which can help you in understanding and identification of your core applications in the broad market.

Based on technology, cell sorting market consists of gradient centrifugation, cell markers-based and sorting on microchips. Cell markers-based segment is further segmented as fluorescence-based droplet cell sorting, magnetic-activated cell sorting (MACS) and micro-electromechanical systems (MEMS)-Microfluidics. Fluorescence-based droplet cell sorting is further sub segmented into jet-in-air cell sorting and cuvette-based cell sorting.

Cell sorting market has been segmented based on product & service into cell sorters, cell sorting reagents & consumables and cell sorting services. Cell sorters have been sub-segmented on the basis of price range into high-range cell sorters (above USD 300,000), mid-range cell sorters (USD 200,000-USD 300,000) and low-range cell sorters (below USD 200,000).

On the basis of applications, cell sorting market has been segmented as research applications and clinical applications. Research applications segment consists of immunology & cancer research, stem cell research, drug discovery and others.

Cell sorting market has also been categorized into research institutes, medical schools & academic institutions, pharmaceutical & biotechnology companies and hospitals & clinical testing laboratories on the basis of end user.

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Cell Sorting Market Country Level Analysis

Global cell sorting market is analysed and market size information is provided by country, technology, product & service, applications and end user as referenced above.

The countries covered in the market report are U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific in the Asia-Pacific, Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa as a part of Middle East & Africa, Brazil, Argentina and Rest of South America as part of South America.

North America will be responsible for having the largest market share in the cell sorting market, whereas Asia-Pacific will hold the highest growth rate. This position of North America is due to the availability of advanced healthcare infrastructure, focus of the market players in the region to advance the levels of cancer research and improvements in therapeutics development processes. Whereas, Asia-Pacific is experiencing high prevalence of chronic diseases such as HIV, cancer and other applicable disorders resulting in lucrative opportunities for market growth in the forthcoming period.

The country section of the report also provides individual market impacting factors and changes in regulation in the market domestically that impacts the current and future trends of the market. Data points such as new sales, replacement sales, country demographics, disease epidemiology and import-export tariffs are some of the major pointers used to forecast the market scenario for individual countries. Also, presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands impact of sales channels are considered while provided forecast analysis of the country data.

Healthcare Infrastructure growth Installed base and New Technology Penetration

Cell sorting market also provides you with detailed market analysis for every country growth in healthcare expenditure for capital equipments, installed base of different kind of products for cell sorting market, impact of technology using life line curves and changes in healthcare regulatory scenarios and their impact on the cell sorting market. The data is available for historic period 2010 to 2018.

Competitive Landscape and Cell Sorting Market Share Analysis

Cell sorting market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, company strengths and weaknesses, product launch, clinical trials pipelines, product approvals, patents, product width and breadth, application dominance, technology lifeline curve. The above data points provided are only related to the companies focus related to cell sorting market.

TTP plc in April 2019 announced that they had invested approximately USD 2.2 million to improve the pace of commercialization for their Highway 1, companys bench-top cell sorting instrument. The instrument is developed to meet the various requirements such as improvements in cell sorting operations of different applications such as cell therapies, liquid biopsy diagnostics and high-throughput drug discovery amongst various others. The instrument has been based on the companys Vortex-Actuated Cell Sorting technology and will be commercialized by Cellular Highways which has been established as a spin-off of TTP plc

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Cell Sorting Market 2020 to Witness Exponential Growth. Top Growing Companies are Breathalyzers, Akers Biosciences Inc., Alcohol Countermeasure...

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From Coronovirus to the Green New Deal – The Bullet – Socialist Project

March 30th, 2020 5:46 am

Environment March 30, 2020 Richard Sandbrook

When we have dealt with the coronavirus crisis, we need to address the climate emergency. We have learned a lot from handling the pandemic that will help in tackling climate change.

Having learned these lessons, one hopes that recovery from the pandemic-recession would be the ideal time to leap to a green economy. Carbon emissions have fallen, as has consumption, and fracking and oil-sands production are no longer economically viable. [Canadian Crude has dropped from $52 a year ago to $8.50 today.] The battle against the coronavirus has demonstrated the importance of public goods such as health services and unemployment benefits and the centrality of collective action in an emergency. To reverse the economic slump, create good jobs and decarbonize the economy, we could massively invest in green energy and green infrastructure.

We could do so. It makes good sense to do so. Many people might now be willing to support such measures. But the problem is that global heating is primarily a political problem. Even with existing technologies, let alone those that will be available within five years, we could attain a carbon-neutral economy in a decade or two. The 2017 book Drawdown: The Most Comprehensive Plan Ever Proposed to Reverse Global Warming presents a hundred ranked solutions to global warming, drawing on the work of about 200 scientists. Climate activists and scientists have reason and evidence-based projections on their side, but power structures and the culture of possessive individualism buttress the existing carbon-intensive system.

The problem is not that we dont know what to do, but that we dont do it. What we should do is implement a Green New Deal that combines socioeconomic transformation with ecological protection. This is rapidly becoming the defining position of the broad left, as ably presented by Naomi Klein in a recent book On Fire: The (Burning) Case for a Green New Deal. But achieving such a goal is fraught with political dangers and obstacles. We need to reckon with these now in order to avoid the shoals. The passage is inevitably perilous.

It is widely believed, at least by those under 40, that only a mass movement creating a lot of disruption can prevail on governments to take climate change seriously. Few readers of The Bullet would disagree. And this is an era of mass protests, many successful. In 2019, these protests occurred on every continent and across 114 countries, in the global south and north. But forming a mass movement, though a difficult challenge by itself, is just the beginning. In a turbulent and polarized era, spontaneity must give way to strategic planning.

Recently, the climate movement has gained considerable momentum. The ramping up of campaigns to divest from carbon stocks, the climate strikes organized by school students throughout the world, the worldwide protests of Extinction Rebellion and other groups. The flurry of dire reports on climatic trends all these events have brought climate issues to the forefront in rich countries. In the US, there is evidence of a cultural shift that has fossil fuel companies running scared. And media outlets are also reporting more and more urgently on climate issues, in some cases (for example UKs The Guardian) adopting the phrases climate crisis or climate emergency in reportage. We are making progress, and the struggle to banish the coronavirus shows what can be done in an emergency. But much more needs to be done.

Reversing global warming at this late stage requires deep changes in production, distribution and consumption. You dont need to be a socialist to accept this statement; it is common sense. If we had seriously responded two or three decades ago, when the science of climate change was already established, more minor actions might have sufficed. A robust and progressive carbon tax, if instituted then, might have been enough. But remediation at this point demands more radical measures.

Consider the magnitude of the challenge. The safe concentration of CO2 in the atmosphere is 350 ppm. In February, readings recorded 413 and 414 ppm. According to NASA, this concentration is higher than its been in 3 million years. Although there is a lag between high concentrations and climate heating, that heating will come even if we achieve a carbon neutral economy. The challenge is not just net-zero emissions but drawing carbon out of the atmosphere. And to hold warming to under 2C (the maximum tolerable change), according to the well-known estimate of the Intergovernmental Panel on Climate Change (IPCC), requires cutting carbon emissions in half in a decade and attaining net-zero by 2050. And that in a time when emissions were rising (until the coronavirus-induced recession).

This urgency has given rise to the advocacy of a Green New Deal (GND), Green Marshall Plans, and Just Transitions. The Leap Manifesto, the forerunner of these programs in Canada, contained most of the elements. They included a transition to 100% renewable energy by 2050, the building of a more just society in the process, the enactment of higher, and new forms of, taxes, and a grassroots movement to back the needed changes and to deepen democracy.

Although Green New Deals (the most popular formulation) vary in their ambition from one iteration to another, the logic is the same. Ecological transformation cannot be achieved without deep economic and social changes, both as an end (to cut emissions) and as a means (to win popular support). The transition to a net-zero carbon economy must be just and systemic to be effective.

Famously or infamously, the GND sponsored by Alexandria Ocasio-Cortez and Ed Markey in the form of a resolution in the US House of Representatives in 2019, follows this logic. Denounced as a socialist plot, the plan is closer to a Rooseveltian New Deal for the 21st century. It calls for a 10-year national mobilization to achieve 100% renewable energy, giant investments in infrastructure and a carbon-free economy, and jobs for all who want to work. Accompanying the transition are measures that are mainstream in Western welfare states: universal healthcare, free higher education, affordable housing, enhanced labour rights, a job guarantee, and remedies for racism. Enforcement of anti-trust laws would, if successful, weaken the economic and political power of oligopolies. We can argue about the degree of systemic change that is needed. Any effective plan, however, must garner support through a vision of a better life, not just fear.

Conservatives, especially right-wing populists, have become climate-deniers, partly on the grounds that combatting climate change is a socialist Trojan horse. They are certainly right that the GND is a progressive project, but whether it is necessarily a socialist project is debatable. It depends partly on ones definition of socialism. For the sake of unity in a diverse movement, that debate is one we should avoid.

Regardless of ones position, we can agree the stakes are high. Powerful interests will lose out, and they will resist.

The deep economic and tax changes required to drastically cut emissions will saddle major corporations and wealthy individuals with major losses in assets, income and power. As reported in the Globe & Mail on 12 Feb 2020, Canadas banking regulator says the financial sector should assume the transition to a low-carbon economy will be sharply negative. A few brief illustrations suggest why.

These threats to the profitability and even survival of major corporations add up to a major challenge to plutocracy.

Plutocracy is a term now widely used, in this neoliberal era, to describe the fusing of economic with political power in Western liberal democracies. The result is that economic and other policies are skewed to the advantage of the top one per cent. This idea is so widely accepted that even economists, mainly the maverick variety such as Paul Krugman, employ the concept.

Its applicability, however, should not be restricted to degraded liberal democracies such as the US and the UK, but extended to authoritarian cases such as Russia and China. In the latter cases, political power has encroached on economic power, a reversal of the process in the West. But the outcome is similar: a power structure highly resistant to the major changes proposed by Green New Deals. True, some investors are attracted to the investment opportunities offered by the green economy. However, the threat to key industries may cast climate activists not as benign tree-huggers, but as security threats.

Even a cursory Google search uncovers disconcerting evidence that security services view climate activists as threats to national security. In the United Kingdom, an anti-extremism briefing issued by the government to all schools and other institutions in late 2019 included environmental groups and anti-racism organizations along with neo-Nazi and Islamist groups in the list of suspects. Greenpeace, Extinction Rebellion, Sea Shepherd, Stop the Badger Cull, PETA and a vegan organization all respectably non-violent in tactics appeared. Readers were advised to be aware of the symbols employed by extremist groups and report any concerns to counter-terrorism police.

In Canada, documents released under Freedom of Information Act revealed that, during the era of Conservative government under Stephen Harper, the two main counter-terrorism agencies regarded environmental and indigenous activists as extremists. Security and police services regularly monitored these activists. Security agencies regarded protests and opposition to Canadas resource-based economy, especially oil and gas, as national-security threats (Guardian, Feb 14, 2013). The National Observer, an award-winning digital newspaper specializing in human-rights issues, reported in 2016 and 2017 that surveillance of environmental activists (which includes indigenous activists) was undertaken by the RCMP (the national police force), Canadian Security and Intelligence Service, provincial police forces and, in some large cities, municipal police forces. Jeffrey Monaghan, a Carleton University criminologist studying espionage, identifies a petro-security apparatus linking security agencies to energy corporations in Canada. This collaboration flows from the alleged threat to critical infrastructure posed by environmental activists. So the warning signs are there.

Its a safe bet that climate activists, albeit engaged in legitimate non-violent action, are under surveillance in plutocracies both western and eastern. And thats in a time of relative calm. Perhaps thats just par for the course in what has been dubbed surveillance capitalism. What is troubling is that the means of surveillance facial recognition and tracking of individuals via their cell phones is now far advanced. Should it come to a crackdown, security agencies will already know who is involved in climate activism and where they live. Civil disobedience will be seen as extremism.

What makes this outcome probable is that the climate crisis is not a stand-alone crisis; it is part of a multi-dimensional crisis of neoliberalism. This unbridled variety of capitalism has fostered problems it is unable to solve. That of course is one reason why the Green New Deals normally advocate social and economic, in addition to ecological, transformation. The Green New Deal is an alternative to neoliberalism, though not necessarily to capitalism. It is a reasonable and just response. That matters little, however, in a context increasingly characterized by dislocation, insecurity and polarization. The multidimensional crisis threatens disorder and therefore property rights. The deeper the disorder and polarization, the more likely a right-wing reaction becomes.

We might describe the simultaneous crises in various ways. They afflict the countries of the global south even more than the north, but here Im narrowing my attention to the latter. In the West in particular, three trends are asserting themselves:

These trends in tandem produce a treacherous environment.

Consider the robotics revolution. The significance of this technological shift is best understood in the context of recent history.

Neither digitalization nor the more recent sharing economy lived up to its early promise of ushering in shared prosperity or more flexible working arrangements. Instead, the neoliberal age has seen inequality and insecurity rise to new levels. This story is well known. The gig economy with its precarious and poorly paid jobs has expanded to encompass one-third of all jobs in the US, according to some estimates. Millennials in particular have had trouble finding good jobs, as well as being saddled with high debts from post-secondary education. Moreover, the economic collapse of 2008 dealt a heavy blow to many in the middle and working classes. Their recovery took years, and it is now threatened by the recession induced by the coronavirus pandemic in 2020.

The fourth industrial revolution of robotics is wreaking further insecurity. The higher productivity wrought by artificial intelligence could lead to a greener, more egalitarian future where available work is shared and working hours shrink. But that will not happen automatically, especially in societies already characterized by inequality, precarious employment and weak democracy.

The employment impact during the next 30 years is likely to be major. Artificial intelligence, as it well understood, displaces workers not just in routine activities in the industrial and service sectors, but in professional occupations as well. A 2017 report by the McKinsey Global Institute estimates that just over half of the waged tasks in 2017 could be done by robots and computers by 2050. In the next decade, 14 per cent of the global workforce will lose their jobs according to the institutes mid-way estimate. The job loss in industrial countries such as the US, Japan and China are much higher than the world average. These estimates, of course, simply tell us what could happen, given technological developments, not what will happen. Political trade-offs and union power, where it exists, may intercede to save jobs. Nonetheless, a lot of people in good jobs as well as bad are going to be out of work.

Economists are confident that the economy will develop new jobs to replace those that are lost: in the longer run. There will be a lag. And will those who lose their jobs be qualified for the tech-savvy, knowledge-based jobs that do emerge? Perhaps if the governments were willing to invest heavily in retraining people for the new economy. However, we cant expect that expensive path to be taken in plutocracies responsive to the demands for the wealthy for lower taxes. We are more likely to see, in many Western countries, further marginalization and inequality.

You dont need to be a rocket scientist, or even a political scientist, to foresee the political dynamics of the unfolding crisis of neoliberalism. Social stress is rising. A growing sense of marginalization and precarity is likely to produce higher anger and resentment, especially at times of recession.

Simultaneously unless we respond swiftly global heating will precipitate extreme weather events that wreak widespread damage. More extensive heat waves, floods, droughts, fresh-water shortages, inundations of coastal cities and islands, falls in agricultural and fishing yields and declines in human health are rendering certain regions uninhabitable while inducing panic.

The consequent population movements add another element of instability. The global south, suffering a more extreme climatic shift than in the north, will witness a growing stream of climate migrants to join the existing refugees displaced by war and disorder. Estimates of the numbers of climate migrants vary, but the most frequent estimate is 150-200 million by 2050. This total includes temporary as well as permanent migrants, and those who are internally displaced as well as cross-border migrants. At the minimum, several millions will join political refugees in heading for sanctuary in Europe, North America and Australia in recurrent waves.

These migrants are the victims of a climatic shift for which they bear virtually no responsibility. The rich countries, having generated most of the carbon in the atmosphere, have an ethical duty to be generous in their reception of these migrants. And yet. The movement of just a million migrants to Europe in 2015-2016 amplified support for right-wing populist parties throughout the continent. The new waves are likely to be far more numerous.

The political danger is clear. With threats to property posed by mass movements and the radical policies of the Green New Deal, concentrated economic power may ally with reactionary political forces. Conservatives feeling under threat from social movements and generalized anxiety will be tempted to turn to reactionary political forces as a means of re-establishing order and safeguarding power and property (as in the 1930s). Hitherto climate-deniers on the right may see in the unfolding of climate change an unparalleled opportunity: to appeal to the ethno-nation, casting migrants and immigrants and their elite enablers as the enemy.

The situation is the more dangerous owing to the decline of democratic institutions. Trust in government has declined during the past two decades world-wide according to numerous surveys. The Edelman Trust Barometer 2020, which surveyed population in 28 countries in late 2019, concluded that a global trust crisis is deepening. More than half the population of developed liberal democracies felt that democracy is losing its effectiveness and 56 per cent believed that capitalism does more harm than good. The far right thrives on declining trust, fear and lies.

Fortress America or Fortress Europe is the opposite of the Green New Deal. It means restricting liberal freedoms, closing borders, blaming aliens, repressing dissent and regulating national economies while safeguarding existing property rights and ethnic and class hierarchies. It involves abandoning the global south to its fate and reversing globalization. Fascism has no viable answer to the climate crisis or the socioeconomic crisis except repression.

Our future could indeed be dark, but our task is to ensure that what could happen, doesnt happen. Within limits, we can make history.

Reversing climate change is a hard sell in societies where right-wing populists have gained a following among the less-educated and more rural elements of the population. Climate change is as much a threat to these elements as to cosmopolitan elites, but the former do not see it that way. Climate change has become entangled in political polarization. Conservative populists have cast climate change as a hoax allowing governing elites to impose new taxes, expand state intervention and welcome new waves of migrants. The populist message resonates with those who feel left behind. Inequality, the exodus of good jobs, and a loss of status in multicultural societies generate resentment, anger and mistrust. Populists have shaped this anger; the left has not.

How then can the climate movement break through the class division? How can they dispel the mistrust to expand their support beyond affluent urbanites and the more highly educated? The only feasible strategy is one that attacks inequality and precarity together with global warming. Hence the importance of the Green New Deal. It envisions a more desirable and feasible future than that offered by nationalist populists.

The GND provides a vision of universal well-being to counter the hateful message of ethno-nationalism. We all the people are vulnerable to climate change, and thus must work in unison. We have a common enemy threatening our future: an economic system that is out of control. We can win the struggle by making a just transition to a net-zero carbon economy through measures that also create an egalitarian, secure and democratic society. That story-line may not work, but its the best available.

But can we forge a broad coalition of progressive forces animated by this vision? Unity and coherence are key. Civil society encompasses a variety of social movements, each with its own agenda, whether social, economic, or ecological. Furthermore, the movements operate at different levels. Some are local, some regional or national, and others transnational. Consequently, there is a cacophony of voices: how do we make them into a choir, singing the same hymn? Presumably, a political party tries to organize and channel the demands. Which party, however?

That raises the issue of the political hue of the GND. Naomi Klein contends, and I agree, that the climate movement is inherently a movement of the left. It seeks social and economic change to achieve its climate objectives. But what left? The fact is that the left has never been good at creating unity (unlike the right); some factions seem more engaged in attacking back-sliders in their own camp than engaging with the real enemy. Achieving an accord is a major challenge.

Can this change, as the threat from the far right escalates? The coalition, to be successful, would surely need to unite most climate activists with left liberals, human-rights defenders, trade unions, social democrats, socialists, indigenous activists, and identity-based groups seeking justice. Perhaps the most fruitful coalition-building strategy is to articulate a powerful vision but offer a program that remains vague in details about the future sustainable society.

But we can all agree that, in means as well as ends, the Green New Deal is a democratic project. Democracy, unfortunately, does not now favour the project of halting global heating. When given the opportunity, electorates throughout the world have voted against, or even rebelled against (as with the gilets jaunes in France), carbon taxes and other inconvenient climate measures. Political polarization and widespread alienation are having this effect. Democracy is thus a gamble, but a necessary one. Only if the Green New Deal is popular will it succeed. Yet if the polarization deepens, the struggle will ultimately be waged between a democratic and egalitarian new deal and an increasingly authoritarian, ultra-nationalist populism.

Finally, we need to counter ethno-nationalism with progressive internationalism. The fight for a Green New Deal cannot be exclusively fought at the national level. Climate change is a global issue and requires global cooperation. I cannot broach the many issues surrounding a progressive international order here. But one contentious issue open borders as part of a just transition does require comment.

Presumptive admission of climate migrants to apparent havens in North America, Europe and Australia is ethically admirable. The emissions that have caused the crisis in the global south have emanated largely from the global north (in addition to China and India more recently). But presumptive admission would likely be politically disastrous. It would provide the Far Right with an issue it could exploit.

If open borders is a policy that is right in principle but disastrous in practice, one is obliged to discuss other options. Winning power or influence is crucial for our success. Certainly, we must support a generous immigration policy. But that will not be enough to fulfill our moral obligation. Major transfers from the rich countries to the global south for mitigating climate change are critical. The Paris Agreement obliges rich countries to make financial and other transfers, but governments have shirked their obligations. A Green New Deal must include provisions for a generous immigration policy (though not presumptive admission for all), together with major transfers of green technologies and financial resources to the beleaguered populations of the global south. Even those pragmatic measures, however, may not be enough to stem the popular appeal of Fortress Europe and Fortress America.

The climate movement, with its allies, is called upon to make history at a critical juncture. The threat posed by climate change is more complex and, in the longer term, more deadly than that posed by the corona virus. But the pandemic has shown what can be done in an emergency. Can we harness the lessons weve learned? Whether we succeed cannot be foretold, and a livable and just world hangs in the balance.

Richard Sandbrook is Professor Emeritus of Political Science, University of Toronto.

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From Coronovirus to the Green New Deal - The Bullet - Socialist Project

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The human DNA is littered with fossils of viruses past that attacked us. And lost – Telegraph India

March 30th, 2020 5:44 am

English naturalist Charles Robert Darwins seminal book On the Origin of Species by Means of Natural Selection went to press in 1859. That was 40 years before the concept of viruses was introduced to the world of science by Russian botanist Dmitri Ivanovsk. It took another century for viral researchers to decipher the genetic make-up of these infectious agents, to find out how they replicate and spread disease.

Darwin shunned and ridiculed after the publication of his book would probably be amazed to know that viruses such as the Covid-19 are considered living evidence of his theory of evolution.

If Charles Darwin reappeared today, he might be surprised to learn that humans are descended from viruses as well as from apes, British microbiologist Robin Weiss wrote in the journal Retrovirology. He was referring to fragments of retroviruses close cousins of the coronavirus found in the human genome.

These fragments are the fossils of a number of killer viruses, including several novel reassortments of influenza or coronaviruses that ravaged humans on a large scale in the past. These so-called endogeneous retroviruses (ERVs) are actually trophies of ancient molecular battles between viruses and their human hosts one which the humans eventually won. Some 8 per cent of human DNA represents fossil retroviral genomes, pointed out Weiss in his seminal research paper in 2010.

When competing groups of scientists in different parts of the world fully mapped the human genome in 2003, they found something they had never anticipated: bits that have no known function. Many scientists termed these seemingly inert shards junk DNA that littered our bodies. In the following decade, however, geneticists realised that some of those bits were actually endogenous retroviruses, fossils of defeated viruses that managed to invade our bodies but were disabled by our immune system. In Darwinian terms, in the struggle for existence our immune system got better of them and there was survival of the fittest through natural selection. Instead of getting buried as mineralised relics, these viruses reside within our DNA as bits of genetic code carrying records of millions of years but forever disabled, with no power to make us sick.

The discovery of the human genome as a living document of ancient and now extinct viruses prompted the emergence of a new field called palaeovirology. Two of its proponents, Michael Emerman and Harmit S. Malik, at the Fred Hutchinson Cancer Research Center in Seattle, US, define palaeovirology as the study of extinct viruses (called palaeoviruses) and the effects these agents have had on the evolution of their hosts. In other words, indirect evidence of these viral fossils can help reconstruct the past and offer clues on how to fight emerging viral epidemics or pandemics.

Malik grew up in Bombay and studied chemical engineering at the Indian Institute of Technology there. He studies evolving proteins and the genetics of evolutionary conflict embedded in the molecules, which has helped him uncover previously unrecognised sources of conflict.

As a pioneer palaeovirologist, Malik is fascinated by the constant battle being waged between humans and viruses for hundreds of thousands of years. In the course of his study, he found telltale imprints in our genome that narrate the story of how viruses infected our cells, how sometimes we have fought back by changing our protein and how sometimes viruses evaded them to get an upper hand. This evolutionary cat-and-mouse game has shaped our defence against viruses.

Palaeovirologists have also studied how similar viruses have attacked our close relatives, the primates chimpanzees and gorillas and compared how we have fared in these battles. For instance, the virus that leads to to the killer disease Aids in humans does not have much of an effect on chimps. What makes chimps relatively immune to this scary virus? Malik and Emerman found the clue to this mystery in an endogenous retrovirus called Pterv found in chimps (and other apes) but not in humans. They surmised that the retrovirus may have infected both humans and chimps about 4 million years ago. We learnt to stave off the virus while the chimps were hit by an epidemic. A gene called Trim 5 alpha is believed to have helped humans make a protein to purge the virus.

Malik and his colleagues reconstructed a part of the Pterv through computer modelling and found that while Trim 5 alpha helped us prevent the entry of the virus, it made us vulnerable to the HIV virus that causes Aids. However, the monkey version of the gene helps protect the apes from HIV and Aids. They concluded that if we can develop a therapy based on the Trim 5 alpha protein, it could defeat HIV. Research on drugs based on such evolutionary principles, however, is few and far between

Scientists have been studying several resurrected palaeoviruses like Pterv through evolution-guided reconstruction procedures. In 2005, researchers at the US Centers for Disease Control and Prevention (CDC), reconstructed the influenza virus that caused the 1918-19 flu pandemic, which killed as many as 50 million people worldwide. According to CDC, the research provides new information about the properties that contributed to its exceptional virulence. The natural emergence of another pandemic virus is considered highly likely by many experts, and therefore insights into pathogenic mechanisms can and are contributing to the development of prophylactic and therapeutic interventions needed to prepare for future pandemic viruses, says a CDC release.

The rapid evolution of viruses and emergence of the new coronavirus Covid-19 has once again shown that viruses evolve by the same means as humans. Many of these viruses hop from animals to humans and evolve, swapping genetic material in and out of respective genomes. Thats why we can have immunity to a virus weve had in the past, but get seriously affected by one our body has never seen before.

Somewhere, Darwin must be feeling vindicated that his theory is so starkly exposed in a viral machinery.

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The human DNA is littered with fossils of viruses past that attacked us. And lost - Telegraph India

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The distorted idea of ‘cool’ brain research is stifling psychotherapy – The Next Web

March 30th, 2020 5:44 am

There is always a well-known solution to every human problem neat, plausible, and wrong.From Prejudices (1920) by H L Mencken

There has never been a problem facing mankind more complex than understanding our own human nature. And no shortage of neat, plausible, and wrong answers purporting to plumb its depths.

Having treated many thousands of psychiatric patients in my career, and having worked on the American Psychiatric Associations efforts to classify psychiatric symptoms (published as the Diagnostic and Statistical Manual of Mental Disorders, or DSM-IV and DSM-5), I can affirm confidently that there are no neat answers in psychiatry. The best we can do is embrace an ecumenical four-dimensional model that includes all possible contributors to human functioning: the biological, the psychological, the social, and the spiritual. Reducing people to just one element their brain functioning, or their psychological tendencies, or their social context, or their struggle for meaning results in a flat, distorted image that leaves out more than it can capture.

The National Institute of Mental Health (NIMH) was established in 1949 by the federal government in the United States with the practical goal of providing an objective, thorough, nationwide analysis and reevaluation of the human and economic problems of mental health. Until 30 years ago, the NIMH appreciated the need for this well-rounded approach and maintained a balanced research budget that covered an extraordinarily wide range of topics and techniques.

But in 1990, the NIMH suddenly and radically switched course, embarking on what it tellingly named the Decade of the Brain. Ever since, the NIMH has increasingly narrowed its focus almost exclusively to brain biology leaving out everything else that makes us human, both in sickness and in health. Having largely lost interest in the plight of real people, the NIMH could now more accurately be renamed the National Institute of Brain Research.

Read: [How tech is helping brain-injured patients with decision-making]

This misplaced reductionism arose from the availability of spectacular research tools (eg, the Human Genome Project, functional magnetic resonance imaging, molecular biology, and machine learning) combined with the naive belief that brain biology could eventually explain all aspects of mental functioning. The results have been a grand intellectual adventure, but a colossal clinical flop. We have acquired a fantastic window into gene and brain functioning, but little to help clinical practice.

The more we learn about genetics and the brain, the more impossibly complicated both reveal themselves to be. We have picked no low-hanging fruit after three decades and $50 billion because there simply is no low-hanging fruit to pick. The human brain has around 86 billion neurons, each communicating with thousands of others via hundreds of chemical modulators, leading to trillions of potential connections. No wonder it reveals its secrets only very gradually and in a piecemeal fashion.

Genetics offers the same baffling complexity. For instance, variation in more than 100 genes contributes to vulnerability to schizophrenia, with each gene contributing just the tiniest bit, and interacting in the most impossibly complicated ways with other genes, and also with the physical and social environment. Even more discouraging, the same genes are often implicated in vulnerability to multiple mental disorders defeating any effort to establish specificity. The almost endless permutations will defeat any easy genetic answers, no matter how many decades and billions we invest.

The NIMH has boxed itself into a badly unbalanced research portfolio. Playing with cool brain and gene research toys trumps the much harder and less intellectually rewarding task of helping real people.

Contrast this current NIMH failure with a great success story from NIMHs distant past. One of the high points of my career was sitting on the NIMH granting committee that funded psychotherapy studies in the 1980s. We helped to support the US psychologist Marsha Linehans research that led her to develop dialectical behavior therapy; the US psychiatrist Aaron T Becks development of cognitive therapy; along with numerous other investigators and themes. Subsequent studies have established that psychotherapy is as effective as medications for mild-to-moderate depression, anxiety, and other psychiatric problems, and avoids the burden of medication side-effects and complications. Many millions of people around the world have already been helped by NIMH psychotherapy research.

In a rational world, the NIMH would continue to fund a robust psychotherapy research budget and promote its use as a public-health initiative to reduce the current massive overprescription of psychiatric medication in the US. Brief psychotherapy would be the first-line treatment of most psychiatric problems that require intervention. Drug treatments would be reserved for severe psychiatric problems and for those people who havent responded sufficiently to watchful waiting or psychotherapy.

Unfortunately, we dont live in a rational world. Drug companies spend hundreds of millions of dollars every year influencing politicians, marketing misleadingly to doctors, and pushing pharmaceutical treatments on the public. They successfully sold the fake marketing jingle that all emotional symptoms are due to a chemical imbalance in the brain and therefore all require a pill solution. The result: 20% of US citizens use psychotropic drugs, most of which are no more than expensive placebos, all of which can produce harmful side-effects.

Drug companies are commercial Goliath with enormous political and economic power. Psychotherapy is a tiny David with no marketing budget; no salespeople mobbing doctors offices; no TV ads; no internet pop-ups; no influence with politicians or insurance companies. No surprise then that the NIMHs neglect of psychotherapy research has been accompanied by its neglect in clinical practice. And the NIMHs embrace of biological reductionism provides an unintended and unwarranted legitimization of the drug-company promotion that there is a pill for every problem.

A balanced NIMH budget would go a long way toward correcting the two biggest mental-health catastrophes of today. Studies comparing psychotherapy versus medication for a wide variety of mild to moderate mental disorders would help to level the playing field for the two, and eventually reduce our massive overdependence on drug treatments for nonexistent chemical imbalances. Health service research is desperately needed to determine best practices to help people with severe mental illness avoid incarceration and homelessness, and also escape from them.

The NIMH is entitled to keep an eye on the future, but not at the expense of the desperate needs of the present. Brain research should remain an important part of a balanced NIMH agenda, not its sole preoccupation. After 30 years of running down a bio-reductionistic blind alley, it is long past time for the NIMH to consider a biopsychosocial reset, and to rebalance its badly uneven research portfolio.

This article was originally published at Aeonby Allen Frances and has been republished under Creative Commons.

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CMSS: 800000 physicians across 40 specialties continue to support travel and gathering restrictions – YubaNet

March 30th, 2020 5:44 am

March 27, 2020

Dear President Trump, Vice President Pence, and Ambassador Birx:

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Thank you for actively engaging the health care communityparticularly the nations physicians and the organizations that represent themin addressing the COVID-19 pandemic in the United States.

As more than 800,000 physicians across more than 40 specialties in medicine, we continue to support travel and gathering restrictions to slow the transmission of coronavirus disease 2019 (COVID-19). Physicians, other health professionals, and staff are putting themselves in harms way without adequate personal protective equipment or necessary tools (such as ventilators) as well as with no proven treatment or vaccine for the virus.

Significant COVID-19 transmission continues across the United States, and we need your leadership in supporting science-based recommendations on social distancing that can slow the virus. Our societies have closely adhered to these measures by moving our staff to fulltime telework and canceling in-person meetings (including annual meetings). These actions have helped to keep physicians and other health professionals in health care facilities, including hospitals, and reduce the risk of spreading COVID-19.

Statewide efforts alone will not sufficiently control this public health crisis. A strong nationwide plan that supports and enforces social distancingand recognizes that our health and our economy are inextricably linkedshould remain in place until public health and medical experts indicate it can be lifted.

Federal, state, and local governments should only set a date for lifting nationwide social distancing restrictions consistent with assessments by public health and medical experts. Lifting restrictions sooner will gravely jeopardize the health of all Americans and extend the devastation of the COVID-19 pandemic.

Again, thank you for actively engaging the nations physicians and the organizations that represent them. We appreciate your considering these comments and welcome an opportunity for further dialogue.

Sincerely,

Council of Medical Specialty Societies

American Academy of Allergy, Asthma & ImmunologyAmerican Academy of DermatologyAmerican Academy of Family PhysiciansAmerican Academy of Hospice and Palliative MedicineAmerican Academy of NeurologyAmerican Academy of OphthalmologyAmerican Academy of Orthopaedic SurgeonsAmerican Academy of PediatricsAmerican Academy of Physical Medicine and RehabilitationAmerican Association of Clinical EndocrinologistsAmerican College of CardiologyAmerican College of Emergency PhysiciansAmerican College of Medical Genetics and GenomicsAmerican College of Obstetricians and GynecologistsAmerican College of Occupational and Environmental MedicineAmerican College of PhysiciansAmerican College of Preventive MedicineAmerican College of RadiologyAmerican College of RheumatologyAmerican College of SurgeonsAmerican Epilepsy SocietyAmerican Gastroenterological AssociationAmerican Geriatrics SocietyAmerican Medical Informatics AssociationAmerican Psychiatric AssociationAmerican Society of AnesthesiologistsAmerican Society for Clinical PathologyAmerican Society of Colon and Rectal SurgeonsAmerican Society of HematologyAmerican Society of NephrologyAmerican Society for Radiation OncologyAmerican Society for Reproductive MedicineAmerican Thoracic SocietyAmerican Urological AssociationAssociation for Clinical OncologyInfectious Diseases Society of AmericaNorth American Spine SocietySociety of Critical Care MedicineSociety of Gynecologic OncologySociety of Hospital MedicineSociety of Interventional RadiologySociety of Nuclear Medicine and Molecular ImagingSociety of Thoracic SurgeonsSociety for Vascular Surgery

Founded in 1965 as the Tri-College Council, CMSS was created to provide an independent forum for the discussion by medical specialists of issues of national interest and mutual concern.Founding members were the American College of Obstetricians and Gynecologists, the American College of Physicians, and the American College of Surgeons.In 1967, as other specialty societies joined, CMSS adopted its current name.Today,43 societies with more than 790,000 U.S. physician membersare members of CMSS. CMSS is a 501(c)(3) not-for-profit association incorporated in the state of Illinois. http://www.cmss.org

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Nanoparticles in Biotechnology and Pharmaceuticals Market 2020 | Growing Rapidly with Significant CAGR, Leading Players, Innovative Trends and…

March 29th, 2020 3:56 am

New Jersey, United States:The Nanoparticles in Biotechnology and Pharmaceuticals Market is carefully researched in the report while largely concentrating on top players and their business tactics, geographical expansion, market segments, competitive landscape, manufacturing, and pricing and cost structures. Each section of the research study is specially prepared to explore key aspects of the Nanoparticles in Biotechnology and Pharmaceuticals market. For instance, the market dynamics section digs deep into the drivers, restraints, trends, and opportunities of the Nanoparticles in Biotechnology and Pharmaceuticals Market. With qualitative and quantitative analysis, we help you with thorough and comprehensive research on the Nanoparticles in Biotechnology and Pharmaceuticals market. We have also focused on SWOT, PESTLE, and Porters Five Forces analyses of the Nanoparticles in Biotechnology and Pharmaceuticals market.

The main players featured in the Nanoparticles in Biotechnology and Pharmaceuticals market report are:

Leading players of the Nanoparticles in Biotechnology and Pharmaceuticals market are analyzed taking into account their market share, recent developments, new product launches, partnerships, mergers or acquisitions, and markets served. We also provide an exhaustive analysis of their product portfolios to explore the products and applications they concentrate on when operating in the Nanoparticles in Biotechnology and Pharmaceuticals market. Furthermore, the report offers two separate market forecasts one for the production side and another for the consumption side of the Nanoparticles in Biotechnology and Pharmaceuticals market. It also provides useful recommendations for new as well as established players of the Nanoparticles in Biotechnology and Pharmaceuticals market.

Nanoparticles in Biotechnology and Pharmaceuticals Market by Regional Segments:

The chapter on regional segmentation describes the regional aspects of the Nanoparticles in Biotechnology and Pharmaceuticals market. This chapter explains the regulatory framework that is expected to affect the entire market. It illuminates the political scenario of the market and anticipates its impact on the market for Nanoparticles in Biotechnology and Pharmaceuticals.

Analysts who have authored the report have segmented the market for Nanoparticles in Biotechnology and Pharmaceuticals by product, application and region. All segments are the subject of extensive research, with a focus on CAGR, market size, growth potential, market share and other important factors. The segment study provided in the report will help players focus on the lucrative areas of the Nanoparticles in Biotechnology and Pharmaceuticals market. The regional analysis will help the actors to strengthen their position in the most important regional markets. It shows unused growth opportunities in regional markets and how they can be used in the forecast period.

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Highlights of TOC:

Overview: In addition to an overview of the Nanoparticles in Biotechnology and Pharmaceuticals market, this section provides an overview of the report to give an idea of the type and content of the study.

Market dynamics: Here the authors of the report discussed in detail the main drivers, restrictions, challenges, trends and opportunities in the market for Nanoparticles in Biotechnology and Pharmaceuticals.

Product Segments: This part of the report shows the growth of the market for various types of products sold by the largest companies.

Application segments: The analysts who have authored the report have thoroughly evaluated the market potential of the key applications and identified the future opportunities they should create in the Nanoparticles in Biotechnology and Pharmaceuticals.

Geographic Segments: Each regional market is carefully examined to understand its current and future growth scenarios.

Company Profiles: The top players in the Nanoparticles in Biotechnology and Pharmaceuticals market are detailed in the report based on their market share, served market, products, applications, regional growth and other factors.

The report also includes specific sections on production and consumption analysis, key results, key suggestions and recommendations, and other issues. Overall, it offers a complete analysis and research study of the Nanoparticles in Biotechnology and Pharmaceuticals market to help players ensure strong growth in the coming years.

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Agricultural Biotechnology Market 2020 | Growing Rapidly with Significant CAGR, Leading Players, Innovative Trends and Expected Revenue by 2026 -…

March 29th, 2020 3:56 am

New Jersey, United States:The Agricultural Biotechnology Market is carefully researched in the report while largely concentrating on top players and their business tactics, geographical expansion, market segments, competitive landscape, manufacturing, and pricing and cost structures. Each section of the research study is specially prepared to explore key aspects of the Agricultural Biotechnology market. For instance, the market dynamics section digs deep into the drivers, restraints, trends, and opportunities of the Agricultural Biotechnology Market. With qualitative and quantitative analysis, we help you with thorough and comprehensive research on the Agricultural Biotechnology market. We have also focused on SWOT, PESTLE, and Porters Five Forces analyses of the Agricultural Biotechnology market.

Global Agricultural Biotechnology Market was valued at USD 35.6 Billion in 2018 and is projected to reach USD 74.92 Billion by 2026, growing at a CAGR of 9.70% from 2019 to 2026.

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The main players featured in the Agricultural Biotechnology market report are:

Leading players of the Agricultural Biotechnology market are analyzed taking into account their market share, recent developments, new product launches, partnerships, mergers or acquisitions, and markets served. We also provide an exhaustive analysis of their product portfolios to explore the products and applications they concentrate on when operating in the Agricultural Biotechnology market. Furthermore, the report offers two separate market forecasts one for the production side and another for the consumption side of the Agricultural Biotechnology market. It also provides useful recommendations for new as well as established players of the Agricultural Biotechnology market.

Agricultural Biotechnology Market by Regional Segments:

The chapter on regional segmentation describes the regional aspects of the Agricultural Biotechnology market. This chapter explains the regulatory framework that is expected to affect the entire market. It illuminates the political scenario of the market and anticipates its impact on the market for Agricultural Biotechnology.

Analysts who have authored the report have segmented the market for Agricultural Biotechnology by product, application and region. All segments are the subject of extensive research, with a focus on CAGR, market size, growth potential, market share and other important factors. The segment study provided in the report will help players focus on the lucrative areas of the Agricultural Biotechnology market. The regional analysis will help the actors to strengthen their position in the most important regional markets. It shows unused growth opportunities in regional markets and how they can be used in the forecast period.

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Highlights of TOC:

Overview: In addition to an overview of the Agricultural Biotechnology market, this section provides an overview of the report to give an idea of the type and content of the study.

Market dynamics: Here the authors of the report discussed in detail the main drivers, restrictions, challenges, trends and opportunities in the market for Agricultural Biotechnology.

Product Segments: This part of the report shows the growth of the market for various types of products sold by the largest companies.

Application segments: The analysts who have authored the report have thoroughly evaluated the market potential of the key applications and identified the future opportunities they should create in the Agricultural Biotechnology.

Geographic Segments: Each regional market is carefully examined to understand its current and future growth scenarios.

Company Profiles: The top players in the Agricultural Biotechnology market are detailed in the report based on their market share, served market, products, applications, regional growth and other factors.

The report also includes specific sections on production and consumption analysis, key results, key suggestions and recommendations, and other issues. Overall, it offers a complete analysis and research study of the Agricultural Biotechnology market to help players ensure strong growth in the coming years.

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Verified market research partners with the customer and offer an insight into strategic and growth analyzes; Data necessary to achieve corporate goals and objectives. Our core values are trust, integrity and authenticity for our customers.

Analysts with a high level of expertise in data collection and governance use industrial techniques to collect and analyze data in all phases. Our analysts are trained to combine modern data collection techniques, superior research methodology, expertise and years of collective experience to produce informative and accurate research reports.

Contact us:

Mr. Edwyne FernandesCall: +1 (650) 781 4080Email: [emailprotected]

Tags: Agricultural Biotechnology Market Size, Agricultural Biotechnology Market Trends, Agricultural Biotechnology Market Forecast, Agricultural Biotechnology Market Growth, Agricultural Biotechnology Market Analysis

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Threat Intelligence Market Size, Growth Analysis, Opportunities, Business Outlook and Forecast to 2026

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Global Agriculture Biotechnology Market Expected to Witness the Highest Growth with ADAMA Agricultural Solutions, Vilmorin, Bayer, Biocentury…

March 29th, 2020 3:56 am

Global Agriculture Biotechnology Market 2019, this report is prepared by in-depth analysis of historical data. The report forecasts the market size by the end of 2026 at an impressive CAGR provided by Reports and Reports. The report offers detailed outline of Agriculture Biotechnology Market and vital market trends. The prime agenda of this report is to provide a detailed analysis of the global, regional and country-level market size, market growth, market status, forecast, sales analysis, value chain optimization, trade regulations, recent developments, opportunities analysis, and importance of the global and national market players, competitive environment, expansion, acquisition, partnerships and technological innovations. The prime market segments considered to prepare this report are key players, regional segments, type and application.

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The Agriculture Biotechnology market report provides a detailed analysis of global market size, regional and country-level market size, segmentation market growth, market share, competitive Landscape, sales analysis, impact of domestic and global market players, value chain optimization, trade regulations, recent developments, opportunities analysis, strategic market growth analysis, product launches, area marketplace expanding, and technological innovations.

The major players covered in Agriculture Biotechnology Market are: ADAMA Agricultural Solutions, Vilmorin, Bayer, Biocentury Transgene, Certis, Dow AgroSciences, Eurofins, Evogene, Global Bio-chem Technology, Syngenta, KWS Saat, Marina Biotech, Monsanto.

Agriculture Biotechnology Industry 2020 Global Market Research report presents an in-depth analysis of the Agriculture Biotechnology market size, growth, share, segments, manufacturers, and technologies, key trends, market drivers, challenges, standardization, deployment models, opportunities, future roadmap and 2026 forecast. The report additionally presents forecasts for Agriculture Biotechnology market revenue, consumption, production, and growth drivers of the market.

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Regions and Countries Level Analysis:

The important regions, considered to prepare this report are North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Colombia), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa). The region wise data analyses the trend, market size of each regions Agriculture Biotechnology Market.

Table of Content (TOC)

Chapter 1: Product definition, type and application, Global market overview;

Chapter 2: Global Market competition by company;

Chapter 3: Global sales revenue, volume and price by type;

Chapter 4: Global sales revenue, volume and price by application;

Chapter 5: United States export and import;

Chapter 6: Company information, business overview, sales data and product specifications;

Chapter 7: Industry chain and raw materials;

Chapter 8: SWOT and Porters Five Forces;

Chapter 9: Conclusion.

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List of Tables and Figures

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Conclusively, this report is a one stop reference point for the industrial stakeholders to get Agriculture Biotechnology Market forecast of till 2026. This report helps to know the estimated market size, market status, future development, growth opportunity, challenges, growth drivers of by analyzing the historical overall data of the considered market segments.

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Scientist says anti-epilepsy drug can be repurposed for Covid-19, writes to ICMR to test it – ThePrint

March 29th, 2020 3:56 am

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New Delhi:A leading scientist at the International Centre for Genetic Engineering and Biotechnology (ICGEB) in New Delhi has found that valproic acid, an anti-epilepsy drug, can be repurposed and used for acute cases of Covid-19.

The scientist, Neel Sarovar Bhavesh, has written to the director general of the Indian Council of Medical Research (ICMR), the apex body in the field, to test valproic acid at the National Institute of Virology in Pune or any ICMR lab to find a quick solution to the coronavirus crisis.

The ICGEB is part of the research consortium working to find a cure and vaccine for Covid-19.

Valproic acid is an approved drug, whose patent expired recently. It is sold under brand names such as Depacon and Stavzor to treat epilepsy. The University of California has also validated the ICGEBs research findings it lists valproic acid as one of the molecules for repurposing and testing for use against the Covid-19 virus.

Also read: AI identifies potential drugs and a DNA vaccine in the works latest on Covid-19

Bhavesh, the head of transcriptional regulation at ICGEB, told ThePrint: We have performed high-throughput virtual screening (HTVS) of 1.2 million small molecules from the four databases, and later performed Energy calculation and molecular binding simulation. We found that valproic acid CoA may be repurposed to inhibit the RNA-dependent RNA polymerase of the virus.

We have written to the DG ICMR to test this molecule on cell culture and animal testing facilities, in combination with potent binding blocking molecules. Currently no one in India outside the NIV and ICMR has access to the Covid-19 virus, Bhavesh said.

About 1,100 strains of the novel coronavirus have been sequenced from around the world. We (in India) have around 700 confirmed positive cases, but only two virus sequences are available at the NIV. These sequences are different from each other, he explained.

Bhavesh revealed that after the publication of the ICGEB research, multinational pharmaceutical company GlaxoSmithKline contacted them.

However, Bhavesh said theres an urgent need for cooperation from government bodies like the ICMR and the NIV in terms of giving researchers access to the virus strains in India to test on.

There should be synchronisation in testing and developing. If NIV or any another research institution finds success, lots of patients can be cured and saved. The need of the hour is to find the solution. The NIV must cooperate with other institutions more generously, he said.

A day before, Union Biotechnology Secretary Renu Swarup also said in an interview that early solutions for the novel coronavirus can be found from repurposed drugs, and that developing new drugs would take time.

Also read: Old drugs, new trials hopes pinned on HIV, malaria, ebola, TB vaccines to fight Covid-19

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20 Indian institutes working to find Covid-19 vaccine, IITs focused on portable ventilators – ThePrint

March 29th, 2020 3:56 am

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New Delhi: Over 20 research institutes are working overnight to develop vaccines for the treatment of the highly infectious novel coronavirus, said a top government official.

The National Institute of Virology (NIV), Pune, and the Indian Council of Medical Research (ICMR) are among these research institutes.

According to Renu Swarup, Secretary, Department of Biotechnology (DBT), which functions under the Ministry of Science and Technology, the government has received over 7,000 tech-based proposals from private companies and individuals across the country to fight Covid-19.

In an interview to ThePrint, Swarup further said the government is dealing with several aspects from scaling up production of low-cost Covid-19 testing kits and ventilators to expediting research for the development of vaccine to fight the novel coronavirus.

We are working on several aspects right now. First is scaling up the manufacturing capacity of those start-ups and incubators, who have made low-cost testing kits and ventilators. They got early approval from the NIV and ICMR also. Eight to nine companies are in the process to get approval for their kits and ventilators, said Swarup.

We are also supporting those companies who got approval for commercial production of testing kits and ventilators. Besides, all IIT-incubators have been asked to focus on research and development of portable ventilators, on genome sequencing and on isolation of the strain of the novel coronavirus from blood samples, she added.

Also read: How do you test for coronavirus? All you want to know about testing kits, process, results

Swarup said IIT-Kanpur and IIT-Roorkee incubation centers are working on making portable ventilators.

We are also supporting three indigenous companies in scaling up their manufacturing capacity of providing ventilators at a fast pace. A Mysuru-based firm is also ramping up its capacity to make more ventilators. It is working with the NITI Aayog, DBT, DRDO (Defence Research and Development Organisation) to manufacture more ventilators, she said.

The DBT is also supporting private companies to procure local components to manufacture ventilators because there is a problem in sourcing them from outside now (in the wake of the lockdown), she added.

An ICMR official told ThePrint ventilators and testing kits are extremely essential if the outbreak reaches the third stage.

India, with less than 1 lakh intensive care units and a bed ratio of 1:1,000, will be at risk if outbreak reaches the third stage. The unique nature of the disease requires 3-4 week of recovery and 21-day ventilator support, said the official.

Ventilators are the next level weapon after a test kit, which is required in sufficient numbers in case of a mass outbreak, he added.

Swarup said the coronavirus research consortium, which has experts from the ICMR, DBT, NIV, are working to develop a vaccine for Covid-19.

We are researching new molecules for treatment. We are researching repurposed drugs to treat patients. More than 45 drugs have been identified that may be effective and research is going on. Several DBT institutions are working to see which formulations can work effectively against Covid-19, she said.

We are also sharing our research with international consortium, which are working on vaccine development. But in any case, it will take time. They are at the animal trial stage and it will reach stage three of human trail not before year end, she added.

Over 7,000 technological solutions were received by the government as part of its COVID-19 Solution Challenge.

Under the initiative, individuals and companies can submit their tech-based ideas for strengthening the fight against coronavirus.

Several tech giants such as Microsoft, Intel, Amazon, Google have pitched ideas for making artificial intelligence-based solutions to detect suspected cases of coronavirus using the ICMR data. Ideas to manufacture low-cost ventilators, low-cost test kits and herbal sanitisers also came, the DBT secretary told ThePrint.

Swarup said all these ideas are being vetted.

A committee headed by K. VijayRaghavan, principal scientific adviser to the government, is evaluating the ideas and the DBT will support the selected research proposal, she added.

The DBT has also invited proposals from companies working in the field of research and development to manufacture ventilators, testing kits, for which it will provide the required funding, the DBT secretary added.

Also read: By failing to scale up testing coronavirus, India may have lost crucial time

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GREEN VISION BIOTECHNOLOGY CORP. : Other Events, Financial Statements and Exhibits (form 8-K) – marketscreener.com

March 29th, 2020 3:56 am

Item 8.01 Other Events.

Green Vision Biotechnology Corp. (the "Company") hereby announces that it isrelying the order of the Securities and Exchange Commission, Release No.34-88318, dated March 4, 2020 for the extension of the filing deadline of itsAnnual Report on Form 10-K, for the year ended December 31, 2019. There was anoutbreak of Coronavirus in China at the end of January, 2020. In order to avoidthe risk of the virus spreading, the Chinese government required enterprises todelay the resumption of work and production, this included City lockdown, travelsuspension, operation suspension, 14-days quarantine, and the work from home.The Company has major operation in Jinzhong, Shanxi and abided by the governmentrule to suspend operation since late January 2020. This has hindered theprogress of performing audit procedures so as to express an appropriate auditopinion for the audit of the Company. Because of the government order to suspendoperation, the Company's accounting staff could not access to the physicalrecords of the Company which cause a delay in providing the relevant informationto the Company's independent public accountant so as to perform the requiredaudit procedures.

The delay to provide responses to auditor inquiries also effected thehardworking of the Company's management because it took more time to collect theappropriate information, access and locate relevant documents, and re-arrangevarious resources. The aforementioned and the subsequent delays relating to thecompletion of audit procedures have caused the filing of the Form 10-K on orbefore April 15, 2020 to become impossible. The Company expects to file theannual report on Form 10-K on May 15, 2020.

Item 9.01 Financial Statements and Exhibits.

Edgar Online, source Glimpses

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Treatment gets five out of Intensive Care – Dominican Today

March 29th, 2020 3:54 am

At least five patients, including some doctors, have overcome the critical state of health in which they had fallen due to the coronavirus and been moved from the Intensive Care units to normal hospital wards, after undergoing an expensive treatment that is producing good results.

Of the patients who have responded adequately to treatment, there are four from Santiago: Dr. Daniel Rivera, president of the Board of Directors of the Unin Mdica Clinic, urologist Fausto Hernndez, ex-governor Jos Izquierdo and patient Juan Ramn. In Santo Domingo, the political leader of San Pedro de Macors, Senator Jos Hazim, while Dr. Felix Antonio Cruz Jiminin has presented significant improvement, although he is still in intensive care with mechanical respiration, admitted to the General Hospital of the Plaza de health.

The details were offered by the Minister of Public Health, Rafael Snchez Crdenas, on the eighth day of the virtual press conference to report the updates to the Covid-19.He said it is a non-over-the-counter medicine that is applied intravenously and is applied to critically ill patients with complicated pneumonia.

A drug used in the treatment of arthritis patients has been applied to these patients.It is tocilizumab, a biological medicine, which is supplied through the High-Cost Medicines Program of the Ministry of Public Health.

Tocilizumab (Actemra) is a biologic medication approved to treat rheumatoid arthritis (RA) in adults, polyarticular juvenile rheumatoid arthritis (JRA), and the systemic form of juvenile idiopathic arthritis (JIA) in children. It isused to suppress the immune system in autoimmune diseases.

Biological drugs are artificial and manufactured using genetic engineering techniques and are closely related to a protein that the body produces naturally.

Dr. Snchez Crdenas reported that there are nine doctors registered with the virus, of whom four were in the process of their work, and others were infected on a cruise or airplane trip, and about three nurses.

He recalled that the highest risk of death is in people over 60 years old and people with co-morbidities, so he called people to take more extreme care of older adults.

Cross-testsThe Minister of Public Health, Rafael Snchez Crdenas, announced that from yesterday the trial would begin with cross-tests at the Dr. Defill National Laboratory, in order to speed up the confirmation of Covid-19 cases.

THE PROCESSSnchez Crdenas revealed that starting today, Saturday, rapid tests of up to 15 minutes will be made, through blood collection obtained from the pulpejo, with patients who have tested positive for other types of tests, to confirm their effectiveness, and then put them into service.

The testsThe effectiveness of rapid tests can be as high as 95%, and the PCR tests, which are being applied in the laboratory, are a specific test with 95% effectiveness, said Crdenas.Those 15-minute rapid tests, of which there are already samples in the country, will be tested today with patients.

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Treatment gets five out of Intensive Care - Dominican Today

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Rheumatoid Arthritis Diagnosis Tests Market to Witness Comprehensive Growth by 2017 2025 – Daily Science

March 29th, 2020 3:54 am

Cutting Equipment Market Scope of the Report:

The global market for Cutting Equipment is expected to grow at a CAGR of roughly xx% over the next five years, will reach xx million US$ in 2029, from xx million US$ in 2018, according to a new study. This report focuses on the Cutting Equipment in global market, especially in North America, Europe and Asia-Pacific, South America, Middle East and Africa. This report categorizes the market based on manufacturers, regions, type and application.

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Rheumatoid Arthritis Diagnosis Tests Market to Witness Comprehensive Growth by 2017 2025 - Daily Science

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Evaluating the Treatment of Acute Gout Flares in the Emergency Department – Rheumatology Advisor

March 29th, 2020 3:54 am

With the rise in number of opioid addictions, alternative long-term care and acute flare management for gout should be further addressed, according to a letter to the editor published in Arthritis Care & Research.1

Researchers previously reported on the diagnosis and treatment of acute gout flares in a 541 consecutive emergency department (ED) visits over a 7-year period.2 They indicated that among patients who visited the ED for an acute gout flare, 35% received an opioid (oxycodone/acetaminophen) and 52% received a prescription for an opioid. According to another study, opioids were prescribed more than 50% of the time in the ED for acute gout flares3; however, the researchers pointed out that the use of analgesia alone does not treat gouty inflammation.

Researchers of this study noted that treatment programs need to consider that gout is a long-term, chronic disease that requires continuous management; the possibility that acute flare-ups can occur must be considered. Research is necessary to address if the use of opioids for acute gout flares in the ED is warranted as well as to establish evidence-based guidelines for treating gout flares.

[T]he clinical importance of this study is that it will increase discussion about the treatment of acute gout flares in the ED and beyond, the investigators concluded.

Disclosure: Several study authors declared affiliations with the pharmaceutical industry. Please see the original reference for a full list of authors disclosures.

References

1. Schlesinger N, Brunetti L. Treatment of acute gout flares in the emergency department [published online February 14, 2020]. Arthritis Care Res (Hoboken). doi:10.1002/acr.24166

2. Oster A, Bindman AB. Emergency department visits for ambulatory care sensitive conditions: insights into preventable hospitalizations. Med Care. 2003;41:198-207.

3. Dalal DS, Mbuyi N, Shah I, Reinert S, Hilliard R, Reginato A. Prescription opioid use among acute gout patients discharged from the emergency department [published July 2, 2019]. Arthritis Care Res. doi:10.1002/acr.23928

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Evaluating the Treatment of Acute Gout Flares in the Emergency Department - Rheumatology Advisor

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BREAKING: Tolicizumab (Actemra) shown to be more effective than hydroxychloroquine in treating coronavirus patients, Italian doctors say -…

March 29th, 2020 3:54 am

For the past two weeks now, weve been talking about hydroxychloroquine as the wonder drug in the fight against the deadly coronavirus. Two anti-malaria drugs hydroxychloroquine and chloroquine are shown to be effective in treating COVID-19 patients after controlled clinical study conducted by doctors in France shows that a combo of Hydroxychloroquine and Azithromycin (Z-Pak) cures 100% of coronavirus patients within 6 days of treatment.

However, according to doctors treating coronovirus patients in Italy, Tolicizumab, a drug used to treat moderate to severe rheumatoid arthritis, has been shown to be more effective than hydroxychloroquine.Tolicizumab is so effective that the FDA gives green lights to Phase III Tocilizumab Trial for COVID-19 pneumonia. In a related report, Italian doctors said that a 101-year-old Italian man who survived the 1918 Spanish flu pandemic and World War II, recovered from COVID-19.

In another report, scientists claim Tocilizumab has been shown to help cure 95 percent of critically ill coronavirus patients in China. Tocilizumab, which is marketed as Actemra, is taken by patients with rheumatoid arthritis toreduce inflammation.Chinese doctors gave it to 20 patients during the peak of of coronavirus epidemic.Nineteen of the patients were discharged within 14 days despite being critically ill.Actemra has now been approved for use in China and for trials in the US

In response to a question from another doctor on hydroxychloroquine, Dr. Giusppe Galati, an Italian doctor, said in a tweet: Dear@DrLuizSilva1despite the large noise on social media. Here in Flag of Italy they are trying several combinations of antiviral included the combination HCQ + azithro. Infectivologist refer little benefit. The unique drug which is causing impressive improvement is#Tolicizumab.

Tocilizumab, also known as atlizumab, is an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of arthritis in children. It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R).

Dear Giuseppe @GiuseppeGalati_ Are the patientes being treated with HCQ an Azithronycin in Italy ? What are the results? Do you start these medicarions as soon as the symptoms begin or late in the courso of disease ?

Dr. Luiz Silva (@DrLuizSilva1) March 20, 2020

The FDA approved the double-blind, randomized phase III clinical trial of the oncology supportive care drug tocilizumab (Actemra) for use in combination with standard of care for the treatment of hospitalized adult patients with severe COVID-19 pneumonia, according to Genentech (Roche), the manufacturer of the interleukin-6 receptor antagonist.

Genentech is also working with the Biomedical Advanced Research and Development Authority (BARDA), a part of the US Health and Human Services Office of the Assistant Secretary for Preparedness and Response (ASPR), to evaluate tocilizumab combined with standard of care versus placebo plus standard of care. In a press release,Genentech said it is providing 10,000 vials of tocilizumab to the United States Strategic national stockpile for potential future use as determined by the US Department of Health and Human Services.

We thank the FDA for rapidly expediting the approval of this clinical trial to evaluate Actemra in critically ill patients suffering from pneumonia following coronavirus infection and were moving forward to enroll as quickly as possible, Alexander Hardy, chief executive officer of Genentech, said in the press release.

Conducting this clinical trial in partnership with BARDA and providing Actemra to support the national stockpile, through the efforts of Secretary Azar and HHS, are important examples of how the US government the biotechnology industry and healthcare communities are working together in response to this public health crisis, added Hardy.

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