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With On-Site Clinics on the Rise, Employers See Productivity and Cost Savings – Occupational Health and Safety

June 23rd, 2020 8:45 am

With On-Site Clinics on the Rise, Employers See Productivity and Cost Savings

On-site clinics are increasingly popular in workplaces, and for good reason. Not only do employees need to monitor their physical and ergonomic health, employers save money by protecting their workers.

Benefits and wellness leaders are increasingly adding on-site natural care clinics to workplaces as a way to further drive a culture of health and wellbeing among employees. Growth forecasts for worksite health offerings are bullish, with the biggest growth area being mid-sized employers (200-500 employees). As the popularity of this offering increasesand employers of all sizes, employees and health professionals work together to focus on preventionemployees experience positive health outcomes and decreased medical expenses.

Designed to reduce employee injury but also enhance employee health and increase productivity, on-site clinics have been known to bridge the gap between information and taking action in one's health, often resulting in reduced stress, improved mental, movement and physical wellbeing.

On-site clinics come in several forms and most recently include complementary and integrative healthcare such as chiropractic, educational and motivational services; balance and workstation assessment; and chair massages. Employees are empowered to engage as the provider, and offering the services has no out-of-pocket cost to them.

While the costs of risk management related to employee health and wellbeing are typically regarded as business overheads, business, operations, benefits and wellness leaders should consider the positive impacts of this long-term investment.

Reduced Healthcare Costs and Injuries

According to a recent survey, disabling workplace injuries cost U.S. companies more than $55 billion per year. Musculoskeletal conditions and poor health habits drive nearly 33 percent of these costs. Workers in construction, manufacturing, healthcare, leisure and hospitality, transportation, retail and professional and business services are at the greatest risk of these injuries. It is in these industries where the repetitive nature of the job can have a negative impact on workers physical health.

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Teens’ technology use and mental health: New report from the Connected Learning Lab provides insight into Youth Connections for Wellbeing – PR Web

June 23rd, 2020 8:45 am

We found that misplaced fears are deflecting attention from other real concerns, resulting in missed opportunities for leveraging technology and online communication to address adolescent mental health problems.

IRVINE, Calif. (PRWEB) June 23, 2020

With or without physical separation due to COVID-19, youth are using social media to connect and support each other, according to a report released today. Three leading researchers have just published Youth Connections for Wellbeing, an integrative review paper that illuminates how teens support each other through digital media during times of stress and isolation.

Leveraging their expertise across the fields of cultural anthropology, developmental psychology, and clinical psychology, scholars Mimi Ito, Candice Odgers, and Stephen Schueller discuss the potential of digital media to support youth wellbeing.

The work underlying the paper was completed prior to the COVID-19 global pandemic. The physical isolation that has resulted from shelter-in-place orders has yielded a seismic shift, making it even more critical to understand and leverage technology in a way that benefits youth.

The position paper summarizes current knowledge and redirects the conversation about adolescent social media use and wellbeing in three ways that are particularly relevant today:

1. Refocusing the debate over the relationship between youth social media use and wellbeing to reflect existing evidence, varied youth perspectives and backgrounds.

2. Identifying teen vulnerabilities and assets that may influence problematic and healthy social media engagement.

3. Suggesting opportunities where youth social engagement might mitigate vulnerabilities and leverage assets.

In the position paper Ito, Odgers, and Schueller highlight the need to move beyond the simple question of whether more time spent using social media causes mental health problems in adolescents. Instead, people should consider the specific forms of social media engagement that amplify or mitigate mental health risks for different adolescents. The team integrates findings from existing large-scale reviews, the voices of youth who have grown up on social media, and a systematic review of digital mental health apps available for youth.

The team finds that adolescents online risks often mirror offline vulnerabilities. They note that it is particularly important for messages, interventions, and strategies to be targeted and tailored to the most vulnerable youth and those underserved by traditional mental health services.

A number of relevant findings, opportunities, and benefits are outlined in the paper, including:

For example, one student interviewed shared how they experienced a supportive community online, saying: I think a lot of my mutuals on Instagram, they're very open to being emotionally vulnerable on Instagram, so they'll actually say, I'm not doing fine. I like it because it's a very nice community, just spreading love whether it be through comments or someone will actually say through messages like, Are you okay?

A freshman adjusting to life away from family shared how online connections made her feel close to them: My mother just started using Messenger. I taught her how to use it. And so she texts me here and there. She's like, Good morning, or, How are you doing?, and then we FaceTime. Then my siblings, we use Instagram because that's where we're mostly at. We send each other videos and memes, and then we kind of comment just to make our day.

Given the rising rates of mental health concerns among young people in the U.S., Ito, Odgers, and Schueller encourage a sense of urgency in focusing research, investment, and public attention on how digital spaces and tools can be better designed and used to support youth's mental health.

The paper, which was supported by Pivotal Ventures (https://www.pivotalventures.org/), a Melinda Gates Company, was published by the Connected Learning Lab at the University of California, Irvine, and is available at https://youthwellbeing.online/ReportRelease.

About the Authors

Mimi Ito is a learning scientist and a cultural anthropologist of technology use, examining children and youths changing relationships to media and communications. She is Director of the Connected Learning Lab, Professor in Residence and John D. and Catherine T. MacArthur Foundation Chair in Digital Media and Learning at the University of California, Irvine.

Candice Odgers is a developmental psychologist who studies adolescent mental health and how digital technologies can be leveraged to understand and support wellbeing. She is the Co-Director of the Child and Brain Development Program at the Canadian Institute for Advanced Research, a Professor of Psychological Science at University of California, Irvine, and a Research Professor at Duke University.

Stephen Schueller is a clinical psychologist and mental health service researcher who focuses on using technology to expand access to and improve the accessibility of mental health services. He is an Assistant Professor of Psychological Science at the University of California, Irvine, and an Adjunct Assistant Professor of Preventive Medicine at Northwestern University, Feinberg School of Medicine.

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From warning on dexamethasone to HCQ: Latest on Covid-19 treatment, vaccines – Hindustan Times

June 23rd, 2020 8:45 am

More than 8.4 million people have contracted the coronavirus disease (Covid-19) and 453,290 have died across the world in nearly six months after it was first reported from Chinas Wuhan late last year.

Around 10 potential vaccines are now undergoing trials in humans, in the hope that a shot to prevent infection can become available in coming months. And even before any vaccines have been proven to work, several countries have already begun making deals with pharmaceutical companies to order doses.

The World Health Organization (WHO) hopes hundreds of millions of doses of coronavirus vaccine can be produced this year and 2 billion doses by the end of 2021, chief scientist Soumya Swaminathan said on Thursday.

The WHO is drawing up plans to help decide who should get the first doses once a vaccine is approved, she said.

Priority would be given to frontline workers such as medics, those who are vulnerable because of age or other illness, and those who work or live in high-transmission settings such as prisons and care homes.

Here are all the latest updates you need to know about Covid-19 vaccines:

Caution on dexamethasone

Dexamethasone, a cheap steroid that can help save the lives of patients with severe Covid-19, should be reserved for serious cases in which it has been shown to provide benefits, the World Health Organization (WHO) has warned.

Mike Ryan, the head of the WHOs emergencies programme, said the drug should only be used in those serious cases where it has been shown to help.

It is exceptionally important in this case, that the drug is reserved for use in severely ill and critical patients who can benefit from this drug clearly, Ryan said during a briefing.

Trial results announced on Tuesday by researchers in Britain showed dexamethasone, a generic drug used since the 1960s to reduce inflammation in diseases such as arthritis, cut death rates by around a third among the most severely ill coronavirus patients admitted to hospital.

The research body involved in the trial was the same one which found evidence that HCQ (Hydroxychloroquine) was not extremely effective on all Covid-19 patients.

That makes it the first drug proved to save lives in fighting the disease. However, some doctors were cautious, citing possible side-effects and asking to see more data.

Volunteers lining up to be infected

Thousands are signing up to take part in a high-stakes experiment willing to deliberately expose themselves to the coronavirus to test a potential vaccine, should researchers decide to proceed.

Known as human-challenge studies, these tests can hasten research by placing volunteers in the path of the virus, rather than waiting for accidental exposure.

Pascal Soriot, chief executive officer of drugmaker AstraZeneca Plc, said the controversial approach may become necessary at some point as the disease ebbs in some cities, making it harder to evaluate shots in the more conventional way.

The company is working with the University of Oxford on one of the most advanced vaccines against the virus.

The initiative is organized by 1DaySooner, a group that advocates on behalf of people who want to join challenge studies. The organisation has held discussions with potential partners and vaccine manufacturers in a bid to start production of the virus, said Josh Morrison, one of its founders.

More than a quarter of the volunteers are in Brazil, where the coronavirus is spreading fast.

Morrison said 1DaySooner has contacted vaccine developers planning final-stage studies there to suggest they consider people on its list for conventional studies, too.

Proponents note that the approach was used safely for diseases such as malaria, typhoid, cholera as well as the flu. Some experts are calling for a cautious approach.

Caution towards polio vaccine for Covid-19

Indian scientists have responded cautiously to a suggestion by global researchers that the oral polio vaccine be tested for Covid-19 treatment, saying it is a testable idea based on a sound scientific concept but may offer only limited protection against the infection.

With a vaccine for Covid-19 at least a year away, scientists say repurposing already safe and effective vaccines is the way to go for immediate relief against Covid-19.

The repurposed vaccines could include the oral polio vaccine (OPV) and the Bacillus CalmetteGuerin (BCG) used against tuberculosis, both part of the immunisation given to Indian children.

It is worth conducting a clinical trial, said Ram Vishwakarma, director of the CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM) in Jammu.

A study was published last week by an international team of researchers in the journal Science. The researchers, including Shyamasundaran Kottili and Robert Gallo from the University of Maryland School of Medicine in the US, said the OPV should be tested to see if it might protect people from the SARS-CoV-2 virus.

They noted that the vaccine used to prevent poliomyelitis infections has been around since the 1950s, and is found to provide some protection against other viral infections.

Hydroxychloroquine wont stop coronavirus deaths

WHOs top scientist has said its now been definitively proven that the cheap malaria drug hydroxychloroquine the drug favoured by President Donald Trump doesnt work in stopping deaths among people hospitalised with the new coronavirus.

But Dr Soumya Swaminathan said there could still be a role for the drug in preventing people from catching Covid-19 in the first place and noted that clinical trials testing hydroxychloroquines role in this are ongoing.

Swaminathan said in a press briefing on Thursday that there is still a gap in determining whether hydroxychloroquine has a role at all in the prevention or minimising the severity of the illness in early infection or even in preventing it.

The UN health agency announced this week that it is suspending the hydroxychloroquine arm of its own trial testing various experimental therapies for Covid-19, referring to previous results from a large UK trial and a separate analysis of the evidence on the drug.

The other drugs being tested by WHO, including treatments used in the past for Ebola and AIDS, are still being pursued.

(With agency inputs)

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From warning on dexamethasone to HCQ: Latest on Covid-19 treatment, vaccines - Hindustan Times

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Achilles Therapeutics doses first patient in Phase I/II Study in advanced non-small cell lung cancer – GlobeNewswire

June 23rd, 2020 8:45 am

Achilles Therapeutics doses first patient in Phase I/II Study in advanced non-small cell lung cancer

Stevenage, UK 23 June 2020 Achilles Therapeutics (Achilles), a clinical stage biopharmaceutical company developing personalised cancer immunotherapies, today announced that it has dosed the first patient in a Phase I/II CHIRON study of a clonal neoantigen T cell (cNeT) therapy in patients with advanced non-small cell lung cancer (NSCLC). In May 2020, Achilles dosed the first patient with cNeT in its Phase I/II THETIS study in recurrent or metastatic malignant melanoma.

Achilles precision tumour-infiltrating lymphocyte (TIL) therapy uses cutting edge genomics to selectively target patient specific clonal neoantigens targets which are believed to be present on all tumour cells this approach has the potential to transform the treatment of cancer.

The CHIRON study is an open-label, multi-centre Phase I/II trial evaluating the safety, tolerability and clinical activity of cNeT therapy as a single dose in adult patients with advanced metastatic NSCLC. The trial is expected to recruit approximately 40 patients and report interim data in the first half of 2021. Recruitment is ongoing across sites in the UK, with additional sites to open in the US and Europe. Link to Study.

The cNeT dosing of the first patient with NSCLC marks another important milestone for Achilles. Our opportunity to serve patients is tremendous as NSCLC remains one of the most prevalent and poorly served of the solid tumours, said Dr Iraj Ali, CEO of Achilles Therapeutics. As with our melanoma study, the CHIRON study is an entirely personalised cell therapy designed to be exquisitely specific and effective and has the potential to help us fundamentally change how certain cancers are treated.

We have been working closely with the Achilles team to design and set up this study across the UK, and are delighted to be dosing the first NSCLC patient with this innovative experimental cell therapy here at University College London Hospital (UCLH), the lead clinical site, said Dr Martin Forster, Associate Professor in Medical Oncology and Study Chief Investigator.

Achilles is developing personalised T cell therapies for solid tumours targeting clonal neoantigens: protein markers unique to each patient that are present on the surface of all cancer cells. Using its PELEUS bioinformatics platform, Achilles can identify clonal neoantigens from each patients unique tumour profile which are present on every cancer cell. Achilles uses its proprietary process to manufacture T cells (cNeT) which exquisitely target a specific set of clonal neoantigens in each patient. Targeting multiple clonal neoantigens that are present on all cancer cells, but not on healthy cells, reduces the risk that new mutations can induce immune evasion and therapeutic resistance, and allows individualised treatments to target and destroy tumours without harming healthy tissue.

- Ends -

Notes for Editors:

About Achilles Therapeutics

Achilles Therapeutics is a clinical stage, biopharmaceutical company developing personalised T cell therapies targeting clonal neoantigens: protein markers unique to the individual that are expressed on the surface of every cancer cell. The Company has two ongoing Phase I/II studies, the THETIS study in patients with recurrent or metastatic malignant melanoma and the CHIRON study in patients with advanced non-small cell lung cancer (NSCLC). Achilles uses DNA sequencing data from each patient, together with the proprietary PELEUS bioinformatics platform, to identify clonal neoantigens specific to that patient, and then develop personalised T cell-based therapies specifically targeting those clonal neoantigens.Achilles was founded in 2016 by lead investor Syncona Ltd and in September 2019 the Company raised 100M in an oversubscribed Series B financing led by RA Capital, cornerstoned by Syncona and joined by new investors including Forbion, Invus, Perceptive Advisors and Redmile Group. For further information please visit the Companys website at:www.achillestx.com

About Lung CancerLung cancer, which forms in the tissues of the lungs, usually within cells lining the air passages, is the leading cause of cancer death worldwide. Each year, more people die of lung cancer than die of colon, breast and prostate cancers combined. The two main types of lung cancer are non-small cell and small cell. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for about 85% of all cases. The five-year survival rate for patients diagnosed in the United States with any stage of lung cancer is estimated to be 18%.

About TRACERxThe TRACERx (TRAcking Cancer Evolution through therapy (Rx)) is a translational research study, led by Achilles founder, Professor Charles Swanton, aimed at transforming our understanding of cancer evolution and take a practical step towards an era of precision medicine.

Despite major advances in the understanding of cancer biology and the translation of these findings into novel therapeutics, the majority of patients with advanced melanoma fail to derive durable clinical benefit from existing standard-of-care therapies. Through integrative analysis of genomic and immunological landscapes, the TRACERx study seeks to address this. Tumour specimens and peripheral blood are studied in highly relevant contexts at multiple stages of a patients treatment journey, from potentially curative resections of locally-advanced disease, through to biopsies of lesions responding or refractory to systemic therapies in the setting of advanced disease.

Wherever possible, analyses will be performed in a longitudinal manner, allowing serial assessment of anti-tumour immunity, tumour-specific genomics and their interaction. Key objectives of the study include determination of spatial and temporal changes in immunological, genomic and transcriptomic landscapes, identification of novel molecular drivers, immunotherapeutic targets and assessment of the impact of cytotoxic, immune-modulatory and targeted therapies on both the tumour microenvironment and peripheral blood.

Further information:

Achilles TherapeuticsDr Iraj Ali Chief Executive Officer+44 (0)1438 906 906media@achillestx.com

Julia Wilson Head of Communications+44 (0)7818 430877j.wilson@achillestx.com

Consilium Strategic CommunicationsMary-Jane Elliott, Sukaina Virji, Melissa Gardiner+44 (0) 203 709 5000achillestx@consilium-comms.com

US Investor Relations - Solebury Trout Lee Stern +1 646-378-2922 lstern@troutgroup.com

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Why a wellness routine is your top priority amid the pandemic and how to start – KSL.com

June 23rd, 2020 8:45 am

NEW YORK (CNN) As states gradually reopen even as the pandemic wears on, many of us are concerned about our health and well-being. Especially now, with some continuing to stay at home and social distance while others join the throngs at nationwide Black Lives Matter protests, it may even be a priority.

From state to state, the loosening of restrictions vary, and within our local communities, the reality is that not only do people have different ideas on what constitutes social distancing but for many others still, in the face of racial inequality, the desire to create social change far outweighs the potential risk of spreading or catching the virus.

It's all the more reason to make sure we're taking the best care of ourselves to fortify against the disease. But while living a healthy life may be a desired goal, how to achieve it is another story.

Even if you're someone whose healthful habits were perfected to a tee during pre-pandemic times, you may find yourself struggling to engage in even the most basic self-care in these increasingly unpredictable days.

That's where a wellness routine can come in handy.

I'm not talking about a spa escape every so often or even regular massages or chef-prepared meals (though all of that may sound really nice). I'm talking about creating your own personalized routine that will benefit you physically and emotionally, one that simply requires a regular commitment to yourself.

Creating a wellness routine allows you to shift from diet culture and adopt healthy habits that easily fit into your daily lifestyle. What's more, having a routine allows you to focus on health goals by creating structure and organization, which can be particularly beneficial when things seem out of your control, like life during an unprecedented pandemic and simultaneous upheaval as people fight against social injustice.

In fact, predictable routines, or ritualistic behavior "developed as a way to induce calm and manage stress caused by unpredictability and uncontrollability, heightening our belief that we are in control of a situation that is otherwise out of our hands," according to researchers at Tel Aviv University.

"We need an internal structure because our external lives have become totally unstructured and that triggers anxiety and stress," said Robin Foroutan, a New York City-based integrative medicine dietitian and spokesperson for the Academy of Nutrition and Dietetics.

"In the beginning, we thought this was going to be a little break; a couple of short weeks, and then we'd resume life as we knew it. Now we know that probably is not going to be the case. We don't know how long this will last, but we can find ways to stay steady and structured on the inside amidst the chaos outside."

Engaging in a wellness routine with a focus on good nutrition, exercise, sleep and stress management can boost our health and well-being and strengthen our immunity during a time when we may need it most.

And while social obligations, travel and other commitments typically make it challenging to start new habits, being stuck at home without these distractions provides an opportune time to start creating a wellness routine that is accessible, doesn't require a lot of money and is something that you can count on during this uncertain time and in the future, too.

Health experts say it's important to create a manageable routine that you can stick with as part of a lifestyle not something overly ambitious that you can't sustain. One way to do that is to start small and build upon it, as you feel comfortable.

Here are some tips to get started in creating your personal wellness routine.

"Most people feel better when they are going to bed and waking up at consistent times, eating regular meals and snacks and getting a steady dose of exercise, said Marysa Cardwell, a registered dietitian, nutrition therapist and certified personal trainer based in Salt Lake City, Utah.

For sleep: Everyone's sleep schedule is different, and that's OK, as long as you stick to your natural circadian rhythms, experts say. That means going to sleep when the sun is setting (or a bit later) and waking up when sun is rising (or a little later, according to your individual needs).

Aiming for seven to nine hours of sleep is key, as it helps to "reduce the stress hormone cortisol and your adrenal load," Cardwell said.

Getting adequate sleep also bodes well for engaging in other healthful behaviors by going to bed at a reasonable hour, you'll be less likely to engage in nighttime eating or mindless eating in front of the TV, and you're more likely to wake up early and start exercise, Cardwell explained.

For eating: Setting regular meal times, and taking a break to eat your food mindfully is key, Cardwell advised, but when you actually eat is up to you. "Some do well on three meals per day with an afternoon snack; others prefer three smaller meals and three snacks."

Regardless of the pattern you choose, aim to eat at least every four hours, which prevents blood sugar from crashing and can lead to overeating. For example, if you're eating three meals and one afternoon snack, you might choose to eat breakfast at 8 a.m., lunch at 12 p.m., a snack at 4 p.m. and dinner at 7 p.m.

Taking a few deep breaths, enjoying the wonderful smells of the food you are about to eat and chewing food really well can all help make mealtime a healthful ritual, Foroutan explained.

Additionally, dinnertime can become a daily social ritual by sharing the meal with family or friends, advised Jen Scheinman, a Denver-based registered dietitian nutritionist and owner of Jen Scheinman Nutrition, a virtual nutrition coaching practice. "Even a Zoom dinner with a friend if you're by yourself can help you feel connected."

For fitness: Pick a time that you're most likely to stick with. That might mean taking a morning walk before your day gets started, or scheduling your favorite fitness class on your calendar so you won't forget.

"I shut my day down with a run or yoga at around 5:30 p.m. That's my last thing for the day. The more you can make it a routine, the less you have to think about it," Scheinman said.

Planning what you will eat and how you will exercise means that you are more likely going to do what you intend to do, which will ultimately help you achieve your health goals. For example, planning meals in advance means you'll be less likely to reach for quick sugary snacks when you run out of energy. It also helps to limit shopping trips.

"Not only does planning your meals ahead of time help cut down on the number of times you're going to the grocery store, but it can also help reduce food waste and ensure you have meals that were intentionally picked to fit your nutritional goals," said Denver-based registered dietitian nutritionist Kelli McGrane.

For food: Eating a nutrient-rich breakfast sets the stage for making other healthful choices throughout the day.

Choose protein-rich breakfasts like egg whites, cottage cheese or smoked salmon on a bagel; Greek yogurt, smoothies with low-fat milk, high fiber cereals with milk or peanut butter on whole wheat toast.

Scheinman recommended preparing breakfast foods ahead of time, like making overnight oats with milk. "It makes the breakfast routine less daunting."

For lunch and dinner, Cardwell encouraged a fist-size portion of protein, such as fish, chicken or beans; a fistful of carbohydrates like whole wheat pasta or brown rice; and a half plate of veggies. This will help meet your micronutrient needs, as well as fiber. Use fats sparingly, as a condiment, to make your food taste better, but limit fried foods and saturated fat, Cardwell advised.

For snacks, choose protein and carb combos, like cheese with crackers, sliced fruit with peanut butter, nuts and seeds with dried fruit or Greek yogurt. Pairing protein with carbs "helps keep your blood sugar level stable, and helps you stay fuller longer," Cardwell said.

Scheinman recommended using the weekends for batch cooking, like making chili or soups, which you can freeze to enjoy later in the week. Washing and chopping veggies and fruit during the weekend can also save you time during the week.

For fitness: Pick a fitness activity that inspires you and is doable. There are a lot of fitness apps offering free trials and online Zoom fitness classes, so you can use this time as an opportunity to try something new. Cardwell recommended aiming for at least 30 minutes per day, if possible.

If you are looking for a simple at-home cardio workout, MaryAnn Browning, founder and CEO of Browningsfitness in New York, recommended jumping jacks, high knees, butt kicks, burpees and switch jumps during which you'll jump to turn 180 degrees and then back again for 15 seconds each. Then repeat the circuit five to 10 times, depending on what you can handle.

For at-home fitness essentials, Browning recommended getting a set of yellow, green and red resistance bands, which can be used for back, bicep, triceps, shoulders and leg work. She also recommended looped bands to go around the calves or thighs, which strengthen the glutes and can help prevent knee and back injuries.

If you want to weight train but don't have equipment, anything that will give you muscle tension will be beneficial, such as jugs of water, books or even your children. "I use my kids I'll do planks and have them sit on me ... or I'll do leg presses while letting them do airplane," Cardwell said.

And don't forget to keep moving throughout your day. Tracking apps like Lose It! are a good way to see how normal daily activities can all count toward our daily fitness goals.

"Dancing with your kids or partner, yard work, house projects, sex and cleaning are all trackable activities. Doing these activities with intention and extra vigor all count towards a healthy lifestyle," said Cardwell, who is also a contributing dietitian for Lose It!

For sleep: Engage in a bedtime routine where you can quiet down and prepare for sleep. "Turn off electronics, including the TV, iPad, and cell phones an hour before bedtime," Scheinman advised. This helps to reduce exposure to blue light, which "the brain perceives as daylight, so your brain is not quite getting the signal that it's nighttime and melatonin is not produced."

Unplugging also prevents you from checking one more email or scrolling through social media while in bed, which can be stimulating and interfere with sleep, Scheinman explained.

Most experts recommended engaging in a morning ritual that brings you pleasure. "Starting your day with the same routine each morning can bring steadiness and calm to the rest of the day. You are starting from a more grounded and positive place, versus waking up; grabbing the phone and checking the news and getting stressed out," Foroutan said.

"The morning is a nice time to start integrating things you didn't have time for previously like taking the dog for a longer walk in the morning, making a nice cup of coffee you can sit and enjoy or engaging in a meditation practice," Scheinman added.

"It sets the day off with a healthy intention, with a sense of comfort. ... I know this is what I do," Scheinman said.

Foroutan enjoys waking up and writing down three things she is grateful for. "Starting the day with a thought about gratitude can be really centering. Writing it down does something extra it solidifies the thought and intention. Not every day is good but there's something good in every day. Even if it's one small thing that gives you a sense of gratitude that's really grounding and it can help shift your perspective."

Stretching your body after you wake up or doing a sun salutation can help to get your blood flowing and your body moving in the morning.

It's also important to prioritize self-care. "Make stress relievers like enjoyable activities a non-negotiable right now," Cardwell said. That may include knitting, taking an extra-long shower or bath, reading, taking a tea break, enjoying a glass of wine or calling family members. Even better, schedule these stress relievers into your day just like mealtimes and other obligations.

"We're taking stock of what's important ... and (our) health is important. Doing these things now can help you deal with the stress of right now," Cardwell said.

It can also keep you healthy and feeling good well into the future, too. That's a gift from quarantine life if there ever is one.

The-CNN-Wire & 2018 Cable News Network, Inc., a Time Warner Company. All rights reserved.

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Global Healthcare Nanotechnology (Nanomedicine) Market 2020 with (Covid-19) Impact Analysis: Business Outlook, Future Growth and Regional Forecasts…

June 22nd, 2020 5:47 am

Researchstore.biz, after comprehensive analysis, has introduced a new research study titled Global Healthcare Nanotechnology (Nanomedicine) Market 2020 by Company, Type and Application, Forecast to 2025, which highlights developments, industry challenges that competitors are facing along with gaps and opportunities available in the market. The report includes the data about the product in the market, marketing patterns pursued by the business, top players, up and coming trends. The report provides an assessment of the market and contains important insights, historical data, and industry-validated market data. The report covers market evolution, overview, value chain, trade scenario, market size, market segmentation, and competitive scenario. Information as per the market segments such as geographies, products, technologies, applications is given in the report.

The report presents insightful analyses of the market and has a comprehensive understanding of the global Healthcare Nanotechnology (Nanomedicine) market industry analysis and forecast 2020-2025 and its commercial landscape. Critical aspects such as impacting factors and competitive landscape are showcased with the help of vital resources, such as charts, tables, and infographics. The complete value chain and downstream and upstream essentials are scrutinized in this report. It additionally seriously explored the global Healthcare Nanotechnology (Nanomedicine) market development pattern based on regional order. Marketing strategies and different channels have been listed here.

DOWNLOAD FREE SAMPLE REPORT: https://www.researchstore.biz/sample-request/47548

NOTE: Our analysts monitoring the situation across the globe explains that the market will generate remunerative prospects for producers post COVID-19 crisis. The report aims to provide an additional illustration of the latest scenario, economic slowdown, and COVID-19 impact on the overall industry.

Key companies profiled in the market report are Amgen, Merck & Co, UCB, Teva Pharmaceuticals, Sanofi, Abbott, Stryker, Celgene, Roche, Biogen, SmitH& Nephew, Takeda, Gilead Sciences, Endo International, Leadiant Biosciences, Johnson & Johnson, Pfizer, Ipsen, Kyowa Hakko Kirin, 3M Company, and more in terms of company basic information, product introduction, application, specification, production, revenue, price and gross margin (2015-2020), etc.

Differentiation of the market based on types of product: Nanomedicine, Nano Medical Devices, Nano Diagnosis, Other

Differentiation of the market based on types of its application: Anticancer, CNS Product, Anti-infective, Other

Geographically, this report studies the top producers and consumers in these key regions: North America (United States, Canada and Mexico), Europe (Germany, France, United Kingdom, Russia and Italy), Asia-Pacific (China, Japan, Korea, India, Southeast Asia and Australia), South America (Brazil, Argentina), Middle East & Africa (Saudi Arabia, UAE, Egypt and South Africa). Here each geographic segment of the Healthcare Nanotechnology (Nanomedicine) market has been independently investigated along with pricing, distribution, and demand data for geographic market.

What Insights Does The Healthcare Nanotechnology (Nanomedicine) Market Report Provide To The Readers?

Moreover, the report focuses on the key global Healthcare Nanotechnology (Nanomedicine) market manufacturers and aims to define, describe and analyze the sales volume, value, market share, market competition landscape, SWOT analysis, and development plans in the next few years. Moreover, for forecasting, regional demand & supply factors, recent investments, market dynamics including technical growth scenario, consumer behavior, and end-user trends, and production capacity are taken into consideration. It also covers a short outline of the dealers, distributors, and suppliers.

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Blindness (2008 film) – Wikipedia

June 22nd, 2020 5:45 am

2008 film directed by Fernando Meirelles

Blindness is a 2008 English-language thriller film and an adaptation of the 1995 novel of the same name by Portuguese author Jos Saramago about a society suffering an epidemic of blindness. The film was written by Don McKellar and directed by Fernando Meirelles, with Julianne Moore and Mark Ruffalo as the main characters. Saramago originally refused to sell the rights for a film adaptation, but the producers were able to acquire it with the condition that the film would be set in an unnamed and unrecognizable city. Blindness premiered as the opening film at the Cannes Film Festival on May 14, 2008, and the film was released in the United States on October 3, 2008.

A young Japanese professional suddenly goes blind in his car at an intersection, his field of vision turning white. A passerby offers to drive him home, then steals his car. His wife returns home and takes him to an ophthalmologist who can identify nothing wrong and refers him for further evaluation.

The next day, the doctor goes blind, and recognizes that it must be caused by a communicable disease. Around the city, more citizens are struck blind, causing widespread panic, and the government organizes a quarantine for the blind in a derelict asylum. When a hazmat crew arrives to pick up the doctor, his wife lies that she has also gone blind in order to accompany him.

In the asylum, the doctor and his wife are first to arrive and agree they will keep her sight a secret. They are joined by several others, including the driver, the thief, and other patients of the doctor. The "white sickness" has become international, with hundreds of cases reported every day. The government is resorting to increasingly ruthless measures to try to deal with the epidemic, refusing aid to the blind.

As more blinded people are crammed into what has become a concentration camp, overcrowding and lack of outside support cause hygiene and living conditions to degrade. The doctor serves as the representative of his ward, and his sighted wife does what she can to assist her fellow inmates without revealing her ability. Anxiety over the availability of food undermines morale and introduces conflict between the prison's wards, as the soldiers who guard the camp become hostile.

A man with a handgun appoints himself "king" of his ward, and takes control of the food deliveries, first demanding the other wards' valuables, and then for the women to have sex with their men. Several women reluctantly submit to being raped. One of the women is killed by her assailant, and the sighted woman retaliates, killing the "king" with a pair of scissors. In the ensuing chaos, the building catches fire, with many inmates dying. The survivors who escape the building discover that the guards have abandoned their posts, and they venture into the city.

Society has collapsed, with the city's population reduced to an aimless, zombie-like struggle to survive. The sighted woman leads her husband and a few others from their ward in search of food and shelter. She discovers a well-stocked basement storeroom beneath a grocery store, barely escaping with aid from her husband when the throng around her smell the fresh food she is carrying.

The doctor and his wife invite their new "family" to their apartment, where they establish a mutually supportive long-term home. The next day, just as suddenly as his sight had been lost, the driver recovers his sight. They celebrate, their hope restored.

Secondary characters include:

Meirelles chose an international cast. Producer Niv Fichman explained Meirelles' intent: "He was inspired by [Saramago's] great masterwork to create a microcosm of the world. He wanted it cast in a way to represent all of humanity."[12]

The rights to the 1995 novel Blindness were closely guarded by author Jos Saramago.[8] Saramago explained, "I always resisted because it's a violent book about social degradation, rape, and I didn't want it to fall into the wrong hands." Director Fernando Meirelles had wanted to direct a film adaptation in 1997, perceiving it as "an allegory about the fragility of civilization". Saramago originally refused to sell the rights to Meirelles, Whoopi Goldberg, or Gael Garca Bernal.[13] In 1999, producer Niv Fichman and Canadian screenwriter Don McKellar visited Saramago in the Canary Islands; Saramago allowed their visit on condition that they not discuss buying the rights. McKellar explained the changes he intended to make from the novel and what the focus would be, and two days later he and Fichman left Saramago's home with the rights. McKellar believed they had succeeded where others had failed because they properly researched Saramago; he was suspicious of the film industry and had therefore resisted other studios' efforts to obtain the rights through large sums of money alone.[14] Conditions set by Saramago were for the film to be set in a country that would not be recognizable to audiences,[15] and that the canine in the novel, the Dog of Tears, should be a big dog.[16]

Meirelles originally envisioned doing the film in Portuguese similar to the novel's original language, but instead directed the film in English, saying, "If you do it in English you can sell it to the whole world and have a bigger audience."[11] Meirelles set the film in a contemporary large city, seemingly under a totalitarian government, as opposed to the novel that he believed took place in the 1940s (actually, the book is more likely to take place in the 80s or later, as evident by the fact that the characters stumble upon a store with modern appliances like microwave ovens and dishwashers, and referral to AIDS as a feared disease). Meirelles chose to make a contemporary film so audiences could relate to the characters.[16] The director also sought a different allegorical approach. He described the novel as "very allegorical, like a fantasy outside of space, outside the world", and he instead took a naturalistic direction in engaging audiences to make the film less "cold."[17]

Don McKellar said about adapting the story, "None of the characters even have names or a history, which is very untraditional for a Hollywood story. The film, like the novel, directly addresses sight and point of view and asks you to see things from a different perspective." McKellar wrote the script so audiences would see the world through the eyes of the protagonist, the doctor's wife. He sought to have them question the humanity of how she observes but does not act in various situations, including a rape scene. He consulted Saramago about why the wife took so long to act. McKellar noted, "He said she became aware of the responsibility that comes with seeing gradually, first to herself, then to her husband, then to her small family, then her ward, and finally to the world where she has to create a new civilization." The screenwriter wrote out the "actions and circumstances" that would allow the wife to find her responsibility.[7] While the completed script was mostly faithful to the novel, McKellar went through several drafts that were not. One such saw him veer away from the novel by creating names and backstories for all the characters. Another significantly changed the chronology. Only after these abortive attempts did McKellar decide to cut the backstories and focus primarily on the doctor and his wife. He attempted to reconnect with what originally drew him to the novel: what he called its "existential simplicity". The novel defines its characters by little more than their present actions; doing the same for the adaptation became "an interesting exercise" for McKellar.[14]

McKellar attended a summer camp for the blind as part of his research. He wanted to observe how blind people interacted in groups. He discovered that excessive expositional dialogue, usually frowned upon by writers, was essential for the groups. McKellar cut one of the last lines in the novel from his screenplay: "I don't think we did go blind, I think we are blind. Blind but seeing. Blind people who can see, but do not see." McKellar believed viewers would by that point have already grasped the symbolism and didn't want the script to seem heavy-handed. He also toned down the visual cues in his screenplay, such as the "brilliant milky whiteness" of blindness described in the novel. McKellar knew he wanted a stylistically adept director and didn't want to be too prescriptive, preferring only to hint at an approach.[14]

Meirelles chose So Paulo as the primary backdrop for Blindness, though scenes were also filmed in Osasco, Brazil; Guelph, Ontario, Canada; and Montevideo, Uruguay. With all the characters aside from Julianne Moore's character being blind, the cast was trained to simulate blindness. The director also stylized the film to reflect the lack of point of view that the characters would experience. Meirelles said several actors he talked to were intimidated by the concept of playing characters without names: "I offered the film to some actors who said, 'I can't play a character with no name, with no history, with no past. With Gael (Garca Bernal), he said, 'I never think about the past. I just think what my character wants.'"[18]

By September 2006, Fernando Meirelles was attached to Blindness, with the script being adapted by Don McKellar. Blindness, budgeted at $25 million as part of a Brazilian and Canadian co-production, was slated to begin filming in summer 2007 in the towns of So Paulo and Guelph.[19] Filming began in early July in So Paulo and Guelph.[20] Filming also took place in Montevideo, Uruguay.[21] So Paulo served as the primary backdrop for Blindness, being a city mostly unfamiliar to U.S. and European audiences. With its relative obscurity, the director sought So Paulo as the film's generic location. Filming continued through autumn of 2007.[8]

The cast and crew included 700 extras who had to be trained to simulate blindness. Actor Christian Duurvoort from Meirelles' City of God led a series of workshops to coach the cast members. Duurvoort had researched the mannerisms of blind people to understand how they perceive the world and how they make their way through space. Duurvoort not only taught the extras mannerisms, but also to convey the emotional and psychological states of blind people.[8] One technique was reacting to others as a blind person, whose reactions are usually different from those of a sighted person. Meirelles described, "When you're talking to someone, you see a reaction. When you're blind, the response is much flatter. What's the point [in reacting]?"[22]

Meirelles acknowledged the challenge of making a film that would simulate the experience of blindness to the audience. He explained, "When you do a film, everything is related to point of view, to vision. When you have two characters in a dialogue, emotion is expressed by the way people look at each other, through the eyes. Especially in the cut, the edit. You usually cut when someone looks over. Film is all about point of view, and in this film there is none."[22] Similar to the book, blindness in the film serves as a metaphor for human nature's dark side: "prejudice, selfishness, violence and willful indifference."[8]

With only one character's point of view available, Meirelles sought to switch the points-of-view throughout the film, seeing three distinct stylistic sections. The director began with an omniscient vantage point, transited to the intact viewpoint of the doctor's wife, and changed again to the Man with the Black Eye Patch, who connects the quarantined to the outside world with stories. The director concluded the switching with the combination of the perspective of the Doctor's Wife and the narrative of the Man with the Black Eye Patch.[7]

The film also contains visual cues, such as the 1568 painting The Parable of the Blind by Pieter Bruegel the Elder. Allusions to other famous artworks are also made. Meirelles described the intent: "It's about image, the film, and vision, so I thought it makes sense to create, not a history of painting, because it's not, but having different ways of seeing things, from Rembrandt to these very contemporary artists. But it's a very subtle thing."[8]

Prior to public release, Meirelles screened Blindness to test audiences. A screening of his first cut in Toronto resulted in ten percent of the audience, nearly 50 people, walking out of the film early. Meirelles ascribed the problem to a rape scene that takes place partway through the film, and edited the scene to be much shorter in the final cut.[23] Meirelles explained his goal, "When I shot and edited these scenes, I did it in a very technical way, I worried about how to light it and so on, and I lost the sense of their brutality. Some women were really angry with the film, and I thought, 'Wow, maybe I crossed the line.' I went back not to please the audience but so they would stay involved until the end of the story."[11] He also found that a New York City test screening expressed concern about a victim in the film failing to take revenge; Meirelles ascribed this as a reflection of what Americans have learned to expect in their cinema.[23]

Focus Features acquired the right to handle international sales for Blindness.[24] Path acquired UK and French rights to distribute the film,[25] and Miramax Films won U.S. distribution rights with its $5 million bid.[26] Blindness premiered as the opening film at the 61st Cannes Film Festival on May 14, 2008,[27] where it received a "tepid reception".[28] Straw polls of critics were "unkind" to the film.[29]

Blindness was screened at the Toronto International Film Festival in September 2008 as a Special Presentation.[30] The film also opened at the Atlantic Film Festival on September 11, 2008,[31] and had its North American theatrical release on October 3, 2008.

Despite being on a number of critics top 10 lists for 2008, the film has received mixed reviews overall, with a 44% approval rating on review aggregator Rotten Tomatoes based on 156 reviews, and the average rating is 5.2 out of 10.[32]

Screen International's Cannes screen jury which annually polls a panel of international film critics gave the film a 1.3 average out of 4, placing the film on the lower-tier of all the films screened at competition in 2008.[33] Of the film critics from the Screen International Cannes critics jury, Alberto Crespi of the Italian publication L'Unit, Michel Ciment of French film magazine Positif and Dohoon Kim of South Korean film publication Cine21, all gave the film zero points (out of four).[33]

Kirk Honeycutt of The Hollywood Reporter described Blindness as "provocative but predictable cinema", startling but failing to surprise. Honeycutt criticized the film's two viewpoints: Julianne Moore's character, the only one who can see, is slow to act against atrocities, and the behavior of Danny Glover's character comes off as "slightly pompous". Honeycutt explained, "This philosophical coolness is what most undermines the emotional response to Meirelles' film. His fictional calculations are all so precise and a tone of deadly seriousness swamps the grim action."[34] Justin Chang of Variety described the film: "Blindness emerges onscreen both overdressed and undermotivated, scrupulously hitting the novel's beats yet barely approximating, so to speak, its vision." Chang thought that Julianne Moore gave a strong performance but did not feel that the film captured the impact of Saramago's novel.[35] Roger Ebert called Blindness "one of the most unpleasant, not to say unendurable, films I've ever seen."[36] A. O. Scott of The New York Times stated that, although it "is not a great film, ... it is, nonetheless, full of examples of what good filmmaking looks like."[37]

Stephen Garrett of Esquire complimented Meirelles' unconventional style: "Meirelles [honors] the material by using elegant, artful camera compositions, beguiling sound design and deft touches of digital effects to accentuate the authenticity of his cataclysmic landscape." Despite the praise, Garrett wrote that Meirelles' talent at portraying real-life injustice in City of God and The Constant Gardener did not suit him for directing the "heightened reality" of Saramago's social commentary.[38]

Peter Bradshaw of The Guardian called it "an intelligent, tightly constructed, supremely confident adaptation": "Meirelles, along with screenwriter Don McKellar and cinematographer Cesar Charlone, have created an elegant, gripping and visually outstanding film. It responds to the novel's notes of apocalypse and dystopia, and its disclosure of a spiritual desert within the modern city, but also to its persistent qualities of fable, paradox and even whimsy." [39] "Blindness is a drum-tight drama, with superb, hallucinatory, images of urban collapse. It has a real coil of horror at its centre, yet is lightened with gentleness and humour. It reminded me of George A Romero's Night of the Living Dead, and Peter Shaffer's absurdist stage-play Black Comedy. This is bold, masterly, film-making."[40]

The Boston Globe's Wesley Morris raved about the leading actress: "Julianne Moore is a star for these terrible times. She tends to be at her best when the world is at its worst. And things are pretty bad in "Blindness," a perversely enjoyable, occasionally harrowing adaptation of Jos Saramago's 1995 disaster allegory. [...] "Blindness" is a movie whose sense of crisis feels right on time, even if the happy ending feels like a gratuitous emotional bailout. Meirelles ensures that the obviousness of the symbolism (in the global village the blind need guidance!) doesn't negate the story's power, nor the power of Moore's performance. The more dehumanizing things get, the fiercer she becomes."[41]

The film appeared on some critics' top ten lists of the best films of 2008. Bill White of the Seattle Post-Intelligencer named it the 5th best film of 2008,[42] and Marc Savlov of The Austin Chronicle named it the 8th best film of 2008.[42]

Meirelles screened the movie privately for Saramago. When the movie ended, Saramago was in tears, and said: "Fernando, I am as happy to have seen this movie as I was the day I finished the book."[43]

The film has been strongly criticized by several organizations representing the blind community. Dr. Marc Maurer, President of the National Federation of the Blind, said: "The National Federation of the Blind condemns and deplores this film, which will do substantial harm to the blind of America and the world."[44] A press release from the American Council of the Blind said "...it is quite obvious why blind people would be outraged over this movie. Blind people do not behave like uncivilized, animalized creatures."[45] The National Federation of the Blind announced plans to picket theaters in at least 21 states, in the largest protest in the organization's 68-year history.[46] Jos Saramago has described his novel as allegorically depicting "a blindness of rationality". He dismissed the protests, stating that "stupidity doesn't choose between the blind and the non-blind."[47]

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The Public Pulse: Wrong decision on masks; Example of white blindness; 11-Worth closing – Omaha World-Herald

June 22nd, 2020 5:45 am

Ricketts wrong on masks

I read with horror the June 18 article about Gov. Pete Ricketts recent threat to withhold funding to local governmental agencies if they require the wearing of face masks in public buildings.

I had hoped that our elected governor would, in this time of national crisis, be acting in the best interests of taxpayers and the electorate. I cannot defend this on any rational or scientific basis.

As a retired M.D., I have spent my life wearing face masks to protect the public. The same people who are denying the usefulness of masks would be horrified and indignant if they walked into an operating room to find their doctors and nurses without face masks. There is no question at all that using masks saves lives, and people who refuse to wear them are putting others at risk for serious illness or death.

I have spent 40 years of my professional life wearing a mask to protect my patients, and now that I am over the age of 60 and therefore at higher risk for serious illness or death, it is appalling that members of the public and our elected governor will not take this simple step to protect me.

The wearing of face masks is simple science and public health. The fact that it has become foolishly and recklessly politicized in this crisis is undermining our recovery and return to normalcy. It shows a profound lack of good judgment and responsibility.

Elizabeth McInerney, Omaha

Poor choices in Senate race

Running for office is exhausting, so is being an elected official. If we expect our elected officials to show good judgment in a time of crisis, then they need to prove through the campaign process that they are up to the job. I appreciate the time, effort and money that Mr. Janicek has put into his campaign; however, with a president who sometimes acts like a racist misogynist, this mistake by Mr. Janisek just shows he is not ready for elected office.

It is too bad because Sen. Sasses graduation speech also showed poor judgment and poor leadership, and he has not shown responsibility for his mistake.

I will be writing in Jane Raybould for the office.

Problem and solution

I am all for people raising their voices at injustice, and I hope we are seeing a true movement to right the wrongs in our country. But I dont think were focusing on the right problem.

Racism is a cancer in our society, and Id like to remind everyone that it isnt restricted to one group or another. (Ive had racism directed at me several times and Im white). Its despicable. Police brutality is terrible, but it isnt restricted to the police either. Id have to say that, statistically speaking, there are fewer bad actors in the police force than in the general population.

If we the people did a better job of policing ourselves, however, maybe we could de-escalate police violence. Maybe if we behaved ourselves, we could defund the police because we no longer need them at their current level. We want to blame the police, but they are not the heart of the problem. We seem to want someone else to solve our problems, wait for them (whoever they are) to act, blame everyone but ourselves. That has to stop. The police departments need to clean up their act, of course, but I also think maybe we owe the police an apology for our own behavior.

We have to take responsibility for our own actions. We have to act as a society to right the wrongs and do our best to bring everyone out of desperate situations. Level society. I dont believe anyone is really sorry for this, but stupid enough to believe the shade of someones skin, their gender, the shape of their eyes or any other external attribute has anything to do with the content of their character. Each of us is either honorable or were not.

The message from kneeling

To Craig M. Barnhart (June 14 Pulse): I genuflect when I enter my church, and kneel during the service. Those being knighted kneel before their king or queen. I knelt when I asked my wife to marry me. None of these, I believe, demonstrates the betrayal or cowardice that you wrote about.

Initially, Kaepernick sat during the anthem, which I did think was disrespectful. Since disrespect was not his goal, he then visited with a military veteran about how to protest with respect; the veteran recommended he kneel.

You may not like it, but it is not disrespectful.

A tainted tax

Former Democrat President Woodrow Wilson was a racist, even by the standards of the early 1900s. Not only did he resegregate the federal government, but he was also a vocal supporter of the KKK.

In 1913, President Wilson signed the Revenue Act into law and thus, the collection of income taxes was born.

Since everything else under the sun can be massaged to be illegitimate due to their racist roots these days, income taxes must be banned.

Evan Trofholz, Columbus, Neb.

Malcolm X Foundations great work

Last weekend, during my weekly video chat with my adult son in Denver, I shared that I was going to participate in a virtual training meeting for non-black allies of Black Lives Matter, live-streamed from the Malcolm X Memorial Foundation. I reminded him of my participation in the Cooperative Urban Teacher Education program in the years just after the period of racial unrest in the late 1960s, and the lifelong influence of that experience on my own commitment to civil rights and social justice causes in Omaha.

My son, though born and raised in Omaha in a household, arts community and church that embraced diversity and inclusion, not only was unaware of the Malcolm X historical site but surprised me by saying, I always admired Malcolm X, but I didnt know he was from Omaha! As we address the issues that have brought our country and community to face the consequences of systemic racism, it is crucial that the citizens of Omaha learn about the legacy of our native son Malcolm X, the Malcolm X Memorial Foundation and the outstanding work it is doing.

The strategy session on Sunday was well-organized, informative and thought-provoking. An opportunity was provided to register for a three-session course to continue our training. The foundation website and Facebook page offer a wealth of resources with background information, history, upcoming events and lectures, and much more. Please research this neglected historical gem, plan a visit to the lovely building and grounds, and take advantage of the events planned to help educate and unify our community.

Example of white blindness

Allen Thomsens June 19 Pulse comments regarding the closing of the 11-Worth restaurant give a perfect window into white blindness. Mr. Thomsen upends his whole argument in his last paragraph. Everyone connected to this restaurant, customers and employees alike, has been irreparably harmed. This is blamed on a stupid, thoughtless Facebook posting, and a menu named after a Civil War general. How in the world has this harmed the demonstrators? (Italics added).

That stupid, thoughtless Facebook post encouraged using lethal force against protesters. Stupid and thoughtless hardly seem strong enough adjectives to describe Tony Juniors comments. And that menu item named after a Civil War general? Mr. Thomsen forgot to mention that the general was the commander of the Confederate Army, a man who used his significant military prowess to try and destroy the very Constitution he had pledged to defend, at the cost of hundreds of thousands of lives, and for the sole purpose of protecting the institution that enslaved millions.

How in the world has this harmed the demonstrators, asks Mr. Thomsen. The answer is, in every conceivable way! It is the public and private expression of such contempt for the lives of not only blacks but those of all the marginalized groups in our society.

To describe the customers and employees of 11-Worth being irreparably harmed by the demonstrators is not just laughable, it is obscene. The only harm they have encountered is from Mr. Caniglias unwillingness to apologize for the racist remarks of his son and his own use of a disgusting, racist symbol of oppression on his menu. Tell me, Mr. Caniglia, would you eat in a restaurant that had a dish named after Mussolini on the menu?

Rev. Richard Lane Bailey, Plattsmouth, Neb.

11-Worth closing

The Caniglia family restaurants have been a mainstay in the Omaha community for many years. My wife and I and friends went to the 11-Worth Caf for breakfast on Sunday mornings many times over the past several years, and it was always crowded. We even enjoyed waiting for a table while we chatted with others who were white, black and shades in between. The food was great and in large portions and not expensive. The wait staff was friendly and efficient and also white, black and shades in between.

We were waiting for the coronavirus to slow down before returning and are now very disappointed that we never will.

One never knows if a peaceful protest will actually be peaceful and safe. Just the threat of violence can be damaging to businesses where they occur. So, to protest organizer David Mitchell and your followers, you were successful in winning your feud with the Caniglia family, putting a good and popular restaurant out of business and making a number of good people unemployed. I bet youre proud of yourselves.

Don Sachs, Council Bluffs

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Diabetic Retinopathy poses a real threat of blindness if untreated – KTBS

June 22nd, 2020 5:45 am

Cataracts are not the only threat to the eyes of a diabetic. Brenda Teele found several other conditions pose a threat, like glaucoma and diabetic retinopathy.

Willis Knight Eye Institute ophthalmologists Christopher Shelby, M.D. and Wyche Coleman, M.D. explained the risks.

The biggest issue with our diabetics is making sure the retina is okay, said Shelby.

While theres often talk about cataracts in a diabetic, theres an even bigger threat to their vision. Cataracts are easy meaning that we can cure that. A five ten minute surgery we take the cataract out put a new lens in theyre doing great. The issue is with their retina, Shelby said.

Doctor Shelby says, because of high glucose levels in a diabetic, bleeding and scaring can occur in the back of the eye, And that can lead to further visual damage.

You know it really doesnt matter if you get the cataract out if you still have a lot of retinal problems. Your retina is like the film on the camera and your cataract is like the lens on the camera, said Coleman.

Dr. Wyche Coleman says its a condition known as diabetic retinopathy. One of the things that we see is that even if the sugar gets tightly controlled, the diabetic retinopathy can progress over time, Coleman said.

And so that scaring can pull on the retina causing traction which could eventually lead to retinal detachment, Shelby explained.

A person diagnosed with Type 2 diabetes is encouraged to get an eye exam immediately.

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A telling example of blindness and privilege – Opinion – The Register-Guard

June 22nd, 2020 5:45 am

TuesdayJun16,2020at12:01AM

Don, I have read your columns and enjoyed your contributions ever since Comic News was in print. But, wow: todays Forgive the rookies column was such a shocking example of white cluelessness that it took my breath away.

You missed the boat so widely that I urge you to apologize before you become a viral hashtag. Please, at least run this by more Black leaders and friends.

I know you didnt intend this, but please understand that your column is a telling example of blindness and privilege. Do you see how you are speaking for blacks, telling them from your place of safety and privilege how they should respond?

Your point about rookie cops was a valid one. But then you took it too far: You actually advised George Floyds family to forgive and you quoted Rev. Dr. Martin Luther King Jr., appropriating him, assuming you knew that he would agree with you! Please do not tell anyone who has been disenfranchised or abused how or when to forgive.

What whites need to be doing right now is listening: shutting up, stepping away from the podium, and listening.

Black voices matter. Black feelings matter.

Heather Henderson, Eugene

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Toxic plant that can cause blindness and third degree burns thriving in Scotland – Daily Record

June 22nd, 2020 5:45 am

Scotland is experiencing a surge in the spread of toxic Giant Hogweed Britains most dangerous plant.

Giant Hogweed is reportedly thriving in lockdown as a result of mild weather and restrictions on maintenance due to Covid-19.

The invasive species contains a sap which can cause extreme third degree burns and blindness if it has contact with eyes, and can even prove fatal to dogs and other animals.

In Dumfries, crime author Karl Drinkwater spotted and 12ft high stem of the plant while walking with his girlfriend near the River Nith.

He told the Record: It seems like the best approach is just to educate people, and for parents to educate their kids, so that people recognise it and are careful around it.

Volunteers armed with herbicide, weedkiller, help maintain the plant across the country.

If left unkept, the plant can thrive especially along Scotlands rivers and coastal routes.

Stuart Brabbs, from the charity Ayrshire River Trust, has been involved in the strategy to maintain it on the River Ayr but says a lack of funding and the constraints of Covid-19 and Brexit have made the plant more difficult to keep at bay.

Stuart told the Record: Its a dangerous plant if you come into contact with it or even brush against it.

It reacts with the sunlight and can cause severe burns.

If someone goes to cut it or takes a strimme r to it they could run the risk of getting it in their eyes which in some cases can cause blindness.

The seed bank for this plant is enormous and can contain around 50-60 thousand seeds which remain viable in the ground for years.

If you have a control plan and then stop, within a short space of time it will grow rapidly.

This year we have received no funding.

"There has also been a spread at the Tarbolton Landfill where it is spreading out of control since the landfill went into receivership."

Giant Hogweed was introduced to Scotland by horticulturists in the 19th Century but it soon spread out of control.

It can often be referred to as giant cow parsley due to its similarities with parsley stalk.

Stuart added: We felt we were heading towards eradication in Ayrshire but theres only so much a charity can do.

I have started hearing reports for the first time of sightings along to coastline of Troon.

We would encourage everybody to avoid contact with this plant.

I think it is possible that Covid 19 will also impact environmental strategies and charitable organisations like ourselves as funding has been noticeably diverted away from environmental actions towards community initiatives tackling hardship.

He continued: Nationally this is a huge problem until SEPA and the Scottish Government tackle it.

Invasive species is one of the things that causes downgrades in our rivers.

Its spreads fast and it will only get worse.

Stuart also believes complications with funding due to Brexit will leave the control strategies in jeopardy.

He said: We will not be able to apply for European funding and that will leave us to the Scottish and UK Government, Im very concerned about that.

For charities and environmental strategies who tirelessly to control invasive species theres uncertainty.

You can report a sighting of Giant Hogweed here.

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Foundation Fighting Blindness to Host Virtual VISIONS 2020 Conference – Yahoo Finance

June 22nd, 2020 5:45 am

The national conference will be held virtually on June 25-27, providing the latest in science and research, practical adapting and thriving, and an opportunity to connect with others who are visually impaired

COLUMBIA, Md., June 16, 2020 /PRNewswire/ --The Foundation Fighting Blindness,the world's leading organization searching for treatments and cures for inherited retinal diseases, will host its VISIONS 2020 national conference virtually on June 25-27, 2020. This new approach to the biennial event will be a free virtual experience, providing a wide range of science and research presentations, practical adapting and thriving sessions, and an opportunity to connect individuals who are affected by visual impairments from across the country.

Participants of Virtual VISIONS 2020 are invited to join live for the opening presentation, "Mission Possible! What's Next for Gene Therapy?" presented by Dr. Shannon Boye, associate professor at University of Florida, and Dr. Ben Yerxa, chief executive officer at the Foundation Fighting Blindness. Paul Karos will serve as the keynote speaker presenting, "Building a Life Beyond Retinal Diseases," sharing his story of living with a visual impairment.

Additional Virtual VISIONS 2020 presentations will include:

"Our new virtual approach to VISIONS 2020 will still allow our Fighting Blindness community to come together and learn about the tremendous progress being made by Foundation funded scientists and clinical researchers," says Ben Yerxa, PhD, chief executive officer at the Foundation Fighting Blindness. "We look forward to bringing this one-of-a-kind virtual experience to our community."

Virtual VISIONS 2020 sponsors include Gold Partner & Accessibility Underwriter, Spark Therapeutics; and Silver Partners, Biogen and Genentech; and Bronze Partners, AGTC, Ora Clinical and Janssen.

To register for Virtual VISIONS 2020 or learn more, visit FightingBlindness.org/VISIONS2020.

About the Foundation Fighting BlindnessEstablished in 1971, the Foundation Fighting Blindness is the world's leading private funding source for retinal degenerative disease research. The Foundation has raised more than $760 million toward its mission of accelerating research for preventing, treating, and curing blindness caused by the entire spectrum of inherited retinal diseases including: retinitis pigmentosa, age-related macular degeneration, Usher syndrome, and Stargardt disease. Visit FightingBlindness.org for more information.

Media Contacts:Chris Adams Vice President, Marketing & Communicationscadams@fightingblindness.org (410) 423-0585

View original content to download multimedia:http://www.prnewswire.com/news-releases/foundation-fighting-blindness-to-host-virtual-visions-2020-conference-301077328.html

SOURCE Foundation Fighting Blindness

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Prevent Blindness Warns Public About the Impact of Firework Injuries to Healthy Eyesight – PR Web

June 22nd, 2020 5:45 am

Prevent Blindness urges the public to celebrate the 4th of July safely this year and avoid using fireworks.

CHICAGO (PRWEB) June 17, 2020

Every year, thousands of Americans are injured due to fireworks, specifically during the 4th of July holiday period. And, according to a recent study, Assessment of Firework-Related Ocular Injury in the US in JAMA Ophthalmology, more than 34,000 firework-related ocular injuries were seen in U.S. emergency departments during the 19-year study period. Ocular burns were the most frequent type of eye injury from fireworks, and bottle rockets were a common firework type that disproportionally caused serious ocular injury, including ruptured globe.

Prevent Blindness, the nations oldest volunteer eye health and safety non-profit organization, urges all consumers to celebrate the holiday safely without using fireworks. Children are at higher risk for injuries from fireworks. The most recent report from the U.S. Consumer Product Safety Commission stated that children 10 to 14 years of age had the highest estimated rate of emergency department-treated, fireworks-related injuries, while older teens, 15 to 19 years of age, had the second highest estimated rate.

According to the American Pyrotechnics Association, Massachusetts is the only state that bans all consumer fireworks, while Illinois, Ohio and Vermont allow only wire or wood stick sparklers and other novelty items. Across the country, many ordinances vary within each state and between different municipalities.

Due to the COVID-19 pandemic, many public displays of fireworks have been cancelled. For those that are still being held, Prevent Blindness warns that anyone who attends a professional display must still be cautious, as accidents and injuries may also occur due to the erratic or unpredictable nature of fireworks.

Prevent Blindness offers alternative ideas to celebrate the holiday safely:

There are so many ways for families to celebrate Independence Day safely without using fireworks, said Jeff Todd, president and CEO of Prevent Blindness. We urge everyone to avoid fireworks and spend the 4th of July with family and friends, instead of in the emergency room.

For more information on the dangers of fireworks, please call Prevent Blindness at (800) 331-2020, or visit http://www.PreventBlindness.org/fireworks.

About Prevent Blindness Founded in 1908, Prevent Blindness is the nation's leading volunteer eye health and safety organization dedicated to fighting blindness and saving sight. Focused on promoting a continuum of vision care, Prevent Blindness touches the lives of millions of people each year through public and professional education, advocacy, certified vision screening and training, community and patient service programs and research. These services are made possible through the generous support of the American public. Together with a network of affiliates, Prevent Blindness is committed to eliminating preventable blindness in America. For more information, or to make a contribution to the sight-saving fund, call 1-800-331-2020. Or, visit us on the Web at http://www.preventblindness.org or facebook.com/preventblindness.

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COVID-19 Impact on Global Vision Care Market Report 2020, Industry Trends, Share, Size and Forecast Till 2025 – Medic Insider

June 22nd, 2020 5:45 am

A new research report by IMARC Group, titled Vision Care Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2020-2025, estimates that the global vision care market reached a value of US$ 60.9 Billion in 2019. Looking forward, IMARC Group expects the market value to reach US$ 72.3 Billion by 2025, at a CAGR of 2.8% during 2020-2025. Eyes are a type of sensory organs which provide vision and help human beings to process visual details. It is essential to take care of the eyes as they are sensitive to trauma, inflammation and infection which can further result in blindness. Good vision plays a vital role in performing various activities such as writing, reading and watching TV among others. It also has a significant effect on the several abilities of a person which include developmental learning, communication and work. Poor vision can impact the day-to-day life of an individual and can also give rise to the symptoms of depression and anxiety.

Request for a sample copy of this report: https://bit.ly/2YVksqh

Market Drivers/Constraints:

There has been a significant rise in the usage of electronic devices such as personal computers, laptops, smartphones and tablets among other devices. As a result, the prevalence of vision-related problems has increased which acts as one of the major factors driving the growth of the market.

There has been a shift towards contact lenses since they have emerged as a better alternative to eye glasses on account of enhanced comfort and vision. This, in turn, has contributed towards an augmented demand for a better vision care across the globe.

Some of the other factors which are positively influencing the growth of the global vision care market include growing brand awareness, changing lifestyles, rising pollution and increasing consciousness among consumers about the importance of a healthy vision.

However, there are a large number of counterfeit products available in the market which can lead to a further damage to the vision. This is one of the primary obstacles which is impeding the growth of the market.

Buy full report with detailed TOC and list of figures and tables: https://bit.ly/2zR6MnI

Insights on Market Segmentation:

Breakup by Product Type

1. Glass Lenses

2. Contact Lenses

3. Intraocular Lenses

4. Contact Solutions

5. Lasik Equipment

6. Artificial Tears

Based on product type, the market has been segmented into glass lenses, contact lenses, intraocular lenses, contact solutions, Lasik equipments and artificial tears. Currently, glass lenses dominate the market owing to the rising prevalence of eye disorders.

Breakup by Distribution Channel

1. Retail Stores

2. Online Stores

3. Clinics

4. Hospitals

On the basis of distribution channel, the market has been segregated into retail stores, online stores and clinics. Amongst these, retail stores hold the majority of the market share and represent the most popular distribution channel.

Breakup by Region

1. North America

2. Europe

3. Asia Pacific

4. Latin America

5. Middle East and Africa

On a geographical front, North America enjoys the leading position in the global vision care market. This can be attributed to the increasing demand for disposable contact lenses along with the rising cases of glaucoma, cataracts and diabetic retinopathy across the region. North America is followed by Europe, Asia Pacific, Latin America, and Middle East and Africa.

Competitive Landscape:

The market is highly fragmented with the presence of numerous small and large manufacturers who compete in terms of prices and quality. Some of the leading players operating in the market are:

Johnson & JohnsonCooperBausch (Valeant Pharmaceuticals)EssilorNovartis AG

About Us

IMARC Group is a leading market research company that offers management strategy and market research worldwide. We partner with clients in all sectors and regions to identify their highest-value opportunities, address their most critical challenges, and transform their businesses.

IMARCs information products include major market, scientific, economic and technological developments for business leaders in pharmaceutical, industrial, and high technology organizations. Market forecasts and industry analysis for biotechnology, advanced materials, pharmaceuticals, food and beverage, travel and tourism, nanotechnology and novel processing methods are at the top of the companys expertise.

Contact Us

IMARC GroupUSA: +1-631-791-1145Email: [emailprotected]Website: https://www.imarcgroup.comFollow us on twitter: @imarcglobal

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Google builds AI agent that learns to generalize to new environments by ignoring distractions – VentureBeat

June 22nd, 2020 5:45 am

In a study earlier this year accepted to the Genetic and Evolutionary Computation Conference (GECCO) 2020, Google researchers investigate the properties of AI software agents that employ self-attention bottlenecks. They claim that these agents not only demonstrate an aptitude for solving challenging vision-based tasks, but that theyre better at tackling slight modifications of the tasks, due to their blindness to details that might confuse them.

Inattentional blindness is the phenomenon that causes a person to miss things in plain sight; its a consequence of selective attention, a mechanism thats believed to enable humans to condense information into a form compact enough for decision-making. Luminaries like Yann LeCunassert it can inspire the design of AI systems that better mimic the elegance and efficiency of biological organisms.

The Google researchers proposed agent AttentionAgent aims to devote most of its attention to task-relevant elements, ignoring distractions. To achieve this, the system segments input images into patches and relies on a self-attention architecture to vote on patches and elect a subset. The elected patches guide AttentionAgents actions as it keeps apprised of changes in the input data, tracking how important factors evolve over time.

In experiments, the team showed that AttentionAgent learned to attend to a range of regions in the images. For instance, they trained it to survive on a level within VizDoom, a digital research environment built on the first-person shooter game Doom, even in environments with walls, floor textures, and signage that it hadnt encountered before. And on the CarRacing game within OpenAIs Gym, a toolkit for developing and comparing reinforcement learning algorithms, AttentionAgent learned to drive during a sunny day and transfer its skills to driving at night, on a rainy day, in a different car, with brighter or darker scenery, and in the presence of visual artifacts. Perhaps more impressively, training in CarRacing required 1,000 times fewer parameters the variables internal to the system that inform its predictions than conventional methods that fail to generalize.

Despite the encouraging results, the researchers note AttentionAgent has serious limitations. It doesnt generalize to cases where dramatic background changes are involved, for example; an agent trained on the CarRacing with a green grass background failed to generalize when the background was replaced with distracting YouTube videos. When the background was replaced with uniform noise, the agent attended to random patches of noise. And while training an agent from scratch with the noisy background enabled it to get around the track, its performance was mediocre.

To motivate future, improved work in selective attention, the researchers released a suite of car racing tasks that involve environmental modifications. Its now available in open source on GitHub. The simplistic method we use to extract information from important patches may be inadequate for more complicated tasks, wrote coauthors Yujin Tang, a research software engineer at Google, and David Ha, a staff research scientist at Google Research in Tokyo. How we can learn more meaningful features, and perhaps even extract symbolic information from the visual input will be an exciting future direction.

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Scientists Uncover Immune Cells That May Help Those Suffering From Allergies and Asthma – SciTechDaily

June 22nd, 2020 5:44 am

These microscopic critters are hard to avoid, which means nearly everyone has been exposed.

Study opens up new path to research to fighting allergic diseases.

The world is full of house dust mites. Do some cleaning, and youll probably stir some up. While everyone has immune cells capable of reacting to common allergens like house dust mites, most of us have no allergic symptoms.

Still, many people do react with the typical allergic symptoms: sneezing, a runny nose, and itchy, swollen nasal passages. Others have a much more severe reaction: a life-threatening asthma attack.

To treat the root cause of allergies and asthma, researchers need to know exactly what sets these patients apart from healthy individuals.

In a new Science Immunology study, published on June 12, 2020, scientists at La Jolla Institute for Immunology (LJI) offer a clue to why non-allergic people dont have a strong reaction to house dust mites. Theyve uncovered a previously unknown subset of T cells that may control allergic immune reactions and asthma from ever developing in response to house dust mites and other possible allergens.

We discovered new immune cell subsets and new therapeutic opportunities, says Grgory Seumois, Ph.D., instructor and director of LJIs Sequencing Core and co-leader of the new study. This new population of cells could be one, out of many unknown mechanisms, that explains why healthy people dont develop inflammation when they breathe in allergens.

The study highlights the power of unbiased single-cell genomics approaches to uncover novel biology, says LJI Professor Pandurangan Vijayanand, M.D. Ph.D., senior author of the new study.

The study builds on the Vijayanand labs expertise in linking gene expression to disease development. The team also took advantage of the Immune Epitope Database, an LJI-led resource that houses information on how the immune system interacts with allergens like house dust mites.

Why house dust mites? These microscopic critters are hard to avoid, which means nearly everyone has been exposed. Even in people without a house dust mite (HDM) allergy, the immune system is likely to react in some way as it learns to recognize HDM molecules. This makes HDM a useful model for studying what causes allergies and asthma attacks.

The LJI team used a technique part of the genomic revolution arsenal of tools, called single-cell RNA-seq (or single cell transcriptomics) to see exactly which genes and molecules specific T cells produce in response to HDM allergens. They tested cells from four groups of people: people with asthma and HDM allergy, people with asthma but no HDM allergy, people with only HDM allergy, and healthy subjects.

Their analysis suggests that a subset of helper T cells, called interleukin (IL)-9 Th2 expressing HDM-reactive cells, is more prevalent in the blood of people with HDM-allergic asthma compared with those who are only allergic to HDM. Further analysis suggested that those IL9-TH2 cells are enriched in a group of molecules/genes that increased the cytotoxic potential of those cells. In other words, those specific T cells could kill other cells and drive inflammation.

In contrast, another subset of T cells stood out in the non-allergic subjects. These T cells express an interferon response signature and were enriched for a gene that encodes a protein called TRAIL. The work done by Seumois and his colleagues suggest that TRAIL could be important because it could dampen the activation of helper T cells.

This finding may mean that people with this specific cell population could have less T-cell driven inflammation in response to HDM allergens. At last, this could provide a clue to why some people develop allergies and asthma while others do not.

Now if functional studies confirm this dampening effect, were curious if there is a way to boost the activation of these T cells or induce their proliferation in asthmatic or allergic populations, says Seumois. Can we act on those cells very early on, before asthma has developed?

For example, genomics studies like this one may someday help identify children at risk of developing asthma and allergies. Early detection could open the door to preemptively acting on immune cells before development of allergy and asthma.

While Seumois emphasizes that there is much more work to be done, he says the transcriptomic method used for this study could accelerate future asthma and allergy research. This is the first large-scale, single-cell, RNA-seq transcriptomic analysis for LJI, says Seumois. Now that we have developed the bench know-how and analysis pipeline, it could be applied to many diseases.

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Reference: Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma by Grgory Seumois, Ciro Ramrez-Sustegui, Benjamin J. Schmiedel, Shu Liang, Bjoern Peters, Alessandro Sette and Pandurangan Vijayanand, 12 June 2020, Science Immunology.DOI: 10.1126/sciimmunol.aba6087

The study, titled Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma, was supported by the National Institutes of Health (grants U19AI100275, U19AI135731, R01HL114093, S10RR027366 and S10 RR027366) and the William K. Bowes Jr. Foundation

Additional study authors included Ciro Ramrez-Sustegui, Benjamin J. Schmiedel, Shu Liang, Bjoern Peters and Alessandro Sette.

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Experts Reversed T-Cells from Attacking Autoimmune Disease Patients to Protecting Them, Here’s How – Science Times

June 22nd, 2020 5:44 am

The immune systemis made up of cells and chemicals that fight infection or microbes that enter the body. B- and T-lymphocytes, also known as a memory cell, keep a record of every microbe that it has ever defeated.

This means that once the microbe enters the body again, the immune system can quickly destroy the microbes before it can multiply and make the host sick.

However, in response to an unknown trigger, the immune system begins to produce antibodies that perceive other cells and tissues in the body as a threat and attack them. This is what autoimmune disordersdo to the human body.

Although some of them, such as allergies, can sometimes be treated, several autoimmune conditions like multiple sclerosis (MS) remains incurable.

According to the researchers, their new study shows how to stop the immune system from attacking the body's cells- or nerves in the case of multiple sclerosis. They give the immune system an ever-increasing doses of the same molecule that it is attacking.

They have taken it a step further to show how this process works in the white blood cells. They revealed the complex mechanisms that made the switch of T-cells from one that attacks cells of autoimmune disease into something that protects it. They also learned how to make reactive T-cells tolerant.

The researchers were able to develop T-cells that can recognize different parts of the molecules made by antigens. The T-cells then start to multiply in order to attack the invaders.

This means that T-cells went from being in a resting state to a highly activated state by switching immune response, which helps them attack pathogens.

So when a person gets cured of the infection, these T-cells become memory T-cellsgiving the person a lifelong immunity.

In autoimmune diseases, T-cell starts to develop myelin basic protein, as an insulating coating that surrounds nerve cells, as an antigen. They attack the nervous system, which makes MS sufferers lose control over their muscles. This is where the new study comes in, as they try to correct this.

Read Also: [WATCH] Scientists Develop 'Nanosponges' That Attract and Neutralize Coronavirus to Render Them Ineffective

In their study, the authors found that T-cells became less reactive after being exposed to gradually increasing doses of the myelin basic protein. This progressive exposure made them weaker and converted them from attacking to protecting.

This switch happened because the immune system is regulated by two types of genes that tell it to attack and silences it to stop going out of control.

Repetitive exposure to the myelin basic protein allowed T-cells to remember to inhibit its receptor from attacking when they encountered that same specific myelin basic protein fragment. When inhibitory genes weakened the signal inside the T-cells, they would also stop receiving the signal telling them to attack nerve cells.

Presently, autoimmune diseases are treated using immunosuppressive drugs. However, using these drugs make the patient more prone to cancers and other infections as they suppress the whole immune system.

Trials using antigen therapy are already underway on patients with MS and Grave's disease. Short-term preliminary clinical trials showed both diseases started to have positive results.

Read more: Coronavirus Has Gone Through 6 Mutations Since January Suggesting Vaccine Development May Become a Cyclical Work: Study

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Evolution of the immune system and modern lifestyle have left us vulnerable to coronavirus – iNews

June 22nd, 2020 5:44 am

As we shelter behind closed doors, the Sars-CoV-2 virus causing Covid-19 has spread like no other disease before. In just a few months, from its identification in December 2019, more than a third of humanity was living under some form of lockdown. It is, to use the clich of 2020, unprecedented.

The Covid-19 pandemic has undeniably and dramatically exposed many weaknesses in human society. But it has also revealed that, despite the enormous advances we have made in medical science and technology, humans are just as vulnerable as any other organism to a novel disease. We are equipped with a very effective immune system that keeps us all alive, but that system has to learn to identify new invaders, and to react appropriately. Our naive immune system renders us all vulnerable to Covid-19, and in some people the overreaction of the immune system in response to the virus, a cytokine storm, can be fatal.

Our immune system, in all its complexity, is an evolved feature. It is an adaptation that, through natural selection, has been shaped and refined to combat disease. But there are subtler aspects of our evolutionary heritage at play during this pandemic. In the modern world of our own creation some of these aspects, so central to our global dominance as a species, can also conspire against us.

Evolution has equipped humans with large and complex brains capable of abstract thought, innovation, language and qualities we term intelligence. The evolved structure of our brain and the thought processes it allows also help us to be social, living and working collectively. Together, these features have allowed humans to achieve truly incredible things. At the same time, some of these features have rendered us horribly and uniquely vulnerable topandemics.

Social behaviour was essential during our evolutionary past, when our ancestors were far more likely to be the hunted than the hunter. Grouping for defence, and using the power of groups to keep safe and extend our diet, went hand-in-hand with evolutionary changes, and larger social units became possible. This accelerated greatly when we latched onto the idea of agriculture. Released to some extent from a foraging existence, human societies expanded, our skulls, dentition and metabolism evolved, technological advances flowed and ever larger settlements became possible. The supercity of the modern world is the culmination of this simultaneous expansion and concentration of humanity. Technology, arising from our unparalleled ability for innovation allows for such control over our environment that sometimes tens of millions of people are able to live a high-rise, high-density lifestyle, literally on top of each other. But high-density urban living provides the perfect conditions for a disease to spread.

The modern lifestyle hugely increases the number of people we have contact with, both socially and when we are crammed together in offices, streets and train carriages. Our social behaviour is now a threat, our conversations a liability. The primary defensive strategy in the face of Covid-19 is to actively and continually oppose our evolutionary heritage and, rather than group together for defence, we must defend ourselves by isolation.

Social distancing is affecting most parts of our daily lives at a local level, but we have also distanced globally. Our large and innovative brains dreamed of flight long before we invented the jet engine and shrank the world. The problem is that our ability to fly is also shared by any diseases we carry with us.

Gathering together people from far and wide for long periods in cramped airports and flying them all over the world is a wonderful dispersal mechanism for a virus like Sars-Cov-2. It is evolution that gave us all the innovative power of our brain, and it is our brain that has allowed us to create a globalised, interconnected world. If viruses had hands they would be have been rubbing them together in anticipatory glee when the Wright brothers took to the air.

Our cerebral evolutionary legacy laid the track for this pandemic but evolved aspects of our bodies arent always helping either. We have a wonderful ability to lay down fatty reserves, and for many of us the modern world is a landscape of caloric potency and opportunity.

Obesity is a major health risk any way you look at it, but it is also emerging as a risk factor for complications arising from Covid-19. The simple evolutionary story of obesity, often repeated, is that we are famine-adapted creatures living in a world of feast. The thrifty gene hypothesis as it is known is a seductive and popular idea, not least because of the implication that getting fat is somehow not our fault.

But it has proved difficult to support. Thrifty genes have been identified, in South Pacific islanders for example, but globally the evidence suggests that obesity cannot be put down to a Boy Scout metabolism, always prepared for famine.

Another evolutionary explanation is that, a few million years ago, the predation risk to our ancestors decreased. Evolved upper limits to fat storage were no longer so restrained by having to run away and they changed upwards not by natural selection but by a process called genetic drift (the drifty gene hypothesis). Whether we are thrifty or drifty, echoes of the mismatch between our evolutionary past and the calorie-filled modern world we have created are being heard.

Beneath our thin veneer of civilisation, far away from the dazzle and glare of our achievements, humans are vulnerable animals. Covid-19 has changed that. It has found itself the perfect host, a species with a powerful evolutionary double-hit of highly social behaviour and an innovative brain, leading to dense urban living and global travel.

The very nature of the modern world, building as it does on our evolutionary heritage, is our weakness in this pandemic. But just as our brain power helped us to get into this, it will also be our way out.

Unfit for Purpose: When Human Evolution Collides with the Modern World by Adam Hart (Bloomsbury Sigma, 16.99) is out now

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Dr. Roach: Does vitamin D have an effect on immunity? – The Detroit News

June 22nd, 2020 5:44 am

Keith Roach, To Your Health Published 6:07 p.m. ET June 19, 2020

Dear Dr. Roach: My wife and I are 74 and in good health. Recently, I started reading about vitamin D and its effect on the immune system. We both had a vitamin D blood test for the first time ever, despite having almost yearly blood tests for the past 40 years. My level was 32 nanograms per milliliter, and hers was 22. She is now taking 50,000 IU of vitamin D weekly on doctors orders. Her blood level is considered insufficient, and mine is barely over the optimal level, although the optimal extends to 100 ng. We have both taken multivitamins for years. How did we get so low, and are our are immune systems compromised? What levels should we be trying to achieve?

E.

Dear E.: Vitamin D has many effects on different tissues of the body, but the data showing definitive benefit to treatment mostly comes from its effect on bone.

Most of the bodys immune cells have the receptor for vitamin D, but evidence that treatment of low vitamin D improves immune function is scant. Randomized trials have examined the effect of vitamin D on upper respiratory infections and tuberculosis, but the benefit was limited to people with VERY low vitamin D levels (less than 10 ng/mL). Studies are ongoing to evaluate the effect of vitamin D supplementation on infection in general, but since very low levels should be treated anyway from the standpoint of bones, there is currently no indication to treat low vitamin D solely in order to prevent or treat infection.

The target level of vitamin D remains controversial. Most experts recommend levels between 20 and 50, which is usually achievable with vitamin D3 doses of 800-2,000 IU daily (I prefer daily to weekly dosing).

Dear Dr. Roach: This 83-year-old male has lost three contemporaries recently to lung diseases: pneumonia, COPD and cancer. Now, the public has been thoroughly educated on the hazards to lung health, such as cigarette smoking, coal mining and asbestos handling. And diet and exercise are promoted for such things as cardiovascular, gastrointestinal and musculoskeletal health, but Ive never seen comparable advice for lung health. Are there any exercises to perform, substances to inhale or foods to eat that will promote my lungs longevity?

R.J.B.

Dear R.J.B.: Humans have enormous lungs if spread out, the surface area of a lung is roughly the size of a tennis court! In a healthy person, lung function rarely, if ever, limits performance. Over time, lung function slowly decreases, and a reasonable goal would be to slow that decrease. Mostly, that means avoiding factors that damage the lung: These are cigarette smoke; other lung irritants such as cooking smoke; indoor and outdoor air pollution; the occupational hazards you mention; and radon in the home. Get your house checked if you live in an area where this is likely; find out where at tinyurl.com/CDC-radon.

There are some proactive steps you can take. One is to reduce your likelihood of infection. Getting your flu shot yearly and your pneumonia vaccines when recommended will help. Serious infection can cause permanent loss of lung function. Diet, especially fruits, have been correlated to improved lung function. Regular, moderate exercise has likewise been shown to slow lung function loss and it certainly helps muscles including the muscles needed to breathe. It also allows cells to get better at extracting oxygen from the blood.

Readers may email questions to ToYourGoodHealth@med.cornell.edu.

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New Cancer Therapies found in the Gut – Innovation Origins

June 22nd, 2020 5:44 am

A pioneering new clinical collaboration between a Cambridge start-up specialised in gut bacteria, and Cancer Care UK, is hoping to transform the approach to treating malignant tumours. Founded in 2016, Microbiotica has received backing from several venture capital funds to conduct its research trials with Cambridge University Hospitals.

The complexity of gut bacteria, known as the microbiome, has become increasingly evident, and its role has been recognised in a host of inflammatory diseases, as well as mental diseases such as depression. In recent years faecal transplants have already been used to treat antibiotic-resistant Clostridioides Difficile infections, that have caused many deaths among hospital patients withcompromised immune systems.

Even more intriguing, however, have been advances in understanding the role played by the microbiome in shaping our immune response to cancer and cancer treatments. The microbiome varies from one individual to another, and in combination with their genes, it is believed to be one of the major causes of why one patient might respond well to treatment, while another suffers debilitating side-effects.

Just like the human genome, the race is on to map the genomes of different species of gut bacteria in order to understand how they can be weaponised against cancer and other diseases. Faecal transplants, which in a small number of cases have caused death by also transplantingincurable pathogens, have long been viewed as a necessary but primitive approach that are only a prelude to far more effective outcomes. Given the sheer complexity of the endeavour, it is no surprise that research is coming of age at a time when huge advances have been made in machine learning and computing power.

Each of us is host to trillions of bacteria in our guts, weighing up to 2.5 kilos, Mike Romanos, CEO, and himself a seasoned researcher, explained to Innovation Origins. Those trillions are on average made up of two to three hundred species out of a possible 1300 or so, with EastAsians having noticeably rich and varied microbiomes and Americans of European descent having the most limited.

Analysing the genomes of these bacteria, as well as their many sub-strains, in order to understand how they interact and modulate our immune system is only part of the challenge. Before that can be done, it requires technology that can extract, isolate, and sequence the genomes ofsamples, while keeping fragile cultures alive at a scale and speed that makes Microbiotica an outlier in its field.

Thanks to a decade of pioneering work by Trevor Lawley at the Sanger institute, which is famous among other things for sequencing 40% of the human genome, we were well ahead of the game at the outset, said Romanos. His research made it possible to isolate the individual bacteria and sequence their entire genomes.

Microbiotica boasts the worlds biggest dataset of gut bacteria species together with their genome sequences, and it has also discovered previously undetected bacteria. Combined with its technological knowhow it can now conduct rigorous and unrivalled research at an industrial scale. It is able to take faecal samples from patients participating in clinical trials in many different areas of medicine, and use its databank to produce analyses that are 100% accurate.

We can conduct shotgun sequencing from stool samples, and map the gut bacteria and its entire genome for individual patients in short time, in a way our rivals simple cant, Romanos added. We have done plenty of benchmarking, and discovered our rivals are often missing up tohalf the gut bacteria in their research.

In an ongoing trial with Genotech, the company has already successfully discovered biomarkers in patients suffering from IBD which can determine whether they will respond positively to certain treatments. The latest oncology collaboration with Cancer Care UK and CambridgeUniversity Hospitals, aims to build on this type of research, and take it a step further.

Some cancers manage to hide from the immune system by triggering what are known as checkpoints in the immune system, thereby switching off an attack directed against them. In recent years a number of new cancer treatments have been developed known as checkpoint inhibitors. One such example is Pembrolizumab. These drugs can restore the immune system and direct it to attack the cancer. Inoperable cancers have been treated very effectively as a result, sometimes withcomplete remission.

Successful immune responses, however, occur in only 30% to 50% of the patients treated, depending on the cancer. It is now hoped that during treatment, co-therapies developed by the likes of Microbiotica, could broaden the effectiveness of these drugs by either finding new ways tomodulate immune responses, or by enabling the selection of patients ahead of treatment who it is known will respond well by identifying key biomarkers that determine their immune response.

Microbiotica was also cofounded by Cambridge Professor, Gordon Dougan, who has previously been a key player in major drug developments with pharmaceutical giants such as GSK. A former WHO advisor and world authority on epidemics and vaccine developments, he has also given his personal take on the current epidemic. According to Ramonos, they are also assessing whether they might have a role to play in helping to stratify patient responses to COVID-19 and future treatments, which have already been shown to be highly individualistic.

There is no shortage of potential partners and investors. The current oncological research being pioneered by Microbiotica is partly funded by venture capital, in particular Cambridge Innovation Capital, which is all too well aware that one checkpoint inhibitor drug alone, known asKeytruda, has an annual revenue of 10 billion dollars. Hence a treatment developed by Microbiotica that could broaden the effectiveness and application of this and other similar drugs, would immediately be able to tap into huge revenue streams.

It is hoped that one of the principal outcomes of Microbioticas collaboration with Cancer Care UK and Cambridge University Hospitals will be to identify specific gut bacterial signatures, and better understand how they assist or reduce the efficacy or side effects of treatments in individual patients.

The clinical studies will involve thousands of patients, making it one of the most rigorous ever conducted in this new area of medicine. In addition to identifying biomarkers, they will also be aiming to cultivate new co-therapies using live bacterial products, derived from the microbiome, which will directly assist the potency of other treatments and diminish, or entirely prevent, some of the often debilitating side effects. The cancers targeted by the research will include melanoma, nonsmall cell lung cancer, and renal cancer.

Visit link:
New Cancer Therapies found in the Gut - Innovation Origins

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