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Case Western Reserve University-led team develops new approach to treat certain neurological diseases – Mirage News

July 3rd, 2020 8:41 pm

A team led by Case Western Reserve University medical researchers has developed a potential treatment method for Pelizaeus-Merzbacher disease (PMD), a fatal neurological disorder that produces severe movement, motor and cognitive dysfunction in children. It results from genetic mutations that prevent the body from properly making myelin, the protective insulation around nerve cells.

Paul Tesar, professor of genetics and genome sciences, School of Medicine

Using mouse models, the researchers identified and validated a new treatment target-a toxic protein resulting from the genetic mutation. Next, they successfully used a family of drugs known as ASOs (antisense oligonucleotides) to target the ribonucleic acid (RNA) strands that created the abnormal protein to stop its production. This treatment reduced PMDs hallmark symptoms and extended lifespan, establishing the clinical potential of this approach.

By demonstrating effective delivery of the ASOs to myelin-producing cells in the nervous system, researchers raised the prospect for using this method to treat other myelin disorders that result from dysfunction within these cells, including multiple sclerosis (MS).

Their research was published online July 1 in the journal Nature.

The pre-clinical results were profound. PMD mouse models that typically die within a few weeks of birth were able to live a full lifespan after treatment, said Paul Tesar, principal investigator on the research, a professor in the Department of Genetics and Genome Sciences at the School of Medicine and the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics. Our results open the door for the development of the first treatment for PMD as well as a new therapeutic approach for other myelin disorders.

Study co-authors include an interdisciplinary team of researchers from the medical school, Ionis Pharmaceuticals Inc., a Carlsbad, California-based pioneer developer of RNA-targeted therapies, and Cleveland Clinic. First author Matthew Elitt worked in Tesars lab as a Case Western Reserve medical and graduate student.

PMD is a rare, genetic condition involving the brain and spinal cord that primarily affects boys. Symptoms can appear in early infancy and begin with jerky eye movements and abnormal head movements. Over time, children develop severe muscle weakness and stiffness, cognitive dysfunction, difficulty walking and fail to reach developmental milestones such as speaking. The disease cuts short life-expectancy, and people with the most severe cases die in childhood.

The disease results from errors in a gene called proteolipid protein 1 (PLP1). Normally, this gene produces proteolipid protein (PLP) a major component of myelin, which wraps and insulates nerve fibers to allow proper transmission of electrical signals in the nervous system. But a faulty PLP1 gene produces toxic proteins that kill myelin producing cells and prevent myelin from developing and functioning properly-resulting in the severe neurological dysfunction in PMD patients.

PMD impacts a few thousand people around the world. So far, no therapy has lessened symptoms or extended lifespans.

For nearly a decade, Tesar and his team have worked to better understand and develop new therapies for myelin disorders. They have had a series of successes, and their myelin-regenerating drugs for MS are now in commercial development.

In the current laboratory work, the researchers found that suppressing mutant PLP1 and its toxic protein restored myelin-producing cells, produced functioning myelin, reduced disease symptoms and extended lifespans.

After validating that PLP1 was their therapeutic target, the researchers pursued pre-clinical treatment options. They knew mutations in the PLP1 gene produced faulty RNA strands that, in turn, created the toxic PLP protein.

Additional team members included Lilianne Barbar, Elizabeth Shick, Yuka Maeno-Hikichi, Mayur Madhavan, Kevin Allan, Baraa Nawash, Artur Gevorgyan, Stevephen Hung, Zachary Nevin, Hannah Olsen, Daniela Schlatzer, David LePage, Weihong Jiang and Ronald Conlon from Case Western Reserve University School of Medicine; Berit Powers, Hien Zhao, Adam Swayze and Frank Rigo from Ionis Pharmaceuticals; and Midori Hitomi from Cleveland Clinic.

This research was supported by grants from the National Institutes of Health, New York Stem Cell Foundation and European Leukodystrophy Association. Philanthropic support was provided by the Geller, Goodman, Fakhouri, Long, Matreyak, Peterson and Weidenthal families and the CWRU Research Institute for Childrens Health.

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Personalized Cancer Drugs Market Expected to Witness a Sustainable Growth over 2025 – 3rd Watch News

July 3rd, 2020 8:41 pm

Global Personalized Cancer Drugs Market: Snapshot

Genetic sequencing has proven that no two cancer cases are absolutely identical, heavily depending on genetic profiles of the patients, which defines their immunity power. But frequently, several promising pipeline drugs fail to reach the market for not being commonly useful for the masses. In this scenario, a small but increasing number of personalized cancer drugs are allowed by the FDA for the treatment of particular mutations. Nearly one third of cancer drugs are prescribed off-label, as it provides help to the patients immediately. These targeted agents are directed at specific molecular feature of the cancer cells and hence produce greater effectiveness with significantly less toxicity.

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The global market for personalized cancer drugs market is gaining traction from increased government support for precision-medicine. For example, in June 2016, the U.S. National Cancer Institutes revealed its plans to enroll thousand patients in a trial called NCI-MATCH, which is aimed at matching patients to twenty possible compounds on the basis of their genetic abnormalities. Along the similar lines, The American Society of Clinical Oncology has also announced a registry termed as TAPUR, collecting data on the fate of patients who receive personalized cancer drugs off-label.

Another factor driving the global personalized cancer drugs market is the falling cost of genetic sequencing, which is enabling the quick approval of drugs for off-label clinical trials on patients in need across the world.

Personalized Cancer Drugs Market: Overview

Personalized drugs, or customized drugs, are tailored to suit the needs of individual patients. Earlier, various patients suffering from the same type of disease were given the similar treatment plan. However, it became evident to physicians that a particular treatment worked differently for different patients, mainly owing to a varied genetic makeup. The concept of personalized medicine is based on the analysis of etiology of disease in individual patients and offers treatment that is more efficient, predictable, and precise.

Cancer is a common chronic disease and a major cause of fatality around the globe. The development of personalized cancer drugs has gained pace as they have relatively fewer side effects compared to standard drugs. Personalized cancer drugs target a specific protein or gene responsible for the growth and survival of a cancer type.

Personalized Cancer Drugs Market: Trends and Opportunities

The personalized cancer drugs market is primarily fueled by the rising prevalence of various cancer types such as lung cancer, breast cancer, prostate cancer, melanoma and leukemia, and colorectal cancer. According to the Surveillance, Epidemiology, and End Results Program sponsored by the National Cancer Institute (NCI), an estimated 13,397,159 people in the United States were affected with various cancer types in 2011. Moreover, in 2014, around 1,666,540 new cancer cases were diagnosed in the country, with nearly 585,720 deaths resulting from cancer. The personalized cancer drugs market is also driven by several advantages associated with this new treatment therapy and ongoing developments in the field of genetic science.

On the flip side, high cost associated with the genetic testing of patients and tumor samples may serve as a growth restraint on the market for personalized cancer drugs. In addition to this, the lack of insurance plans to cover these tests in developing nations of Asia Pacific and Rest of the World hampers the market to some extent. This can be attributed to low per capita income and poor reimbursement scenario.

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Personalized Cancer Drugs Market: Geographical Assessment

From a geographical perspective, the personalized cancer drugs market has been broadly segmented into Europe, Asia Pacific, North America, and Rest of the World (RoW). The market for personalized cancer drugs is led by North America. The chief factors responsible for the regions lead position are aggressive research and development activities, technical advancements, higher affordability for expensive treatments and therapies, and greater healthcare awareness. Europe is also a key market for personalized cancer drugs owing to significant funding from several governments and the growing penetration by U.S.-based companies.

Asia Pacific holds immense promise for players in the personalized cancer drugs market, powered mainly by Japan. The regional market is likely to be fueled by the presence of a large pool of cancer patients and improving healthcare infrastructure. The growth of the APAC personalized cancer market can also be attributed to the rapidly evolving medical tourism industry. In the RoW segment, Mexico, Brazil, Russia, and South Africa represent potential markets.

Personalized Cancer Drugs Market: Competitive Landscape

Some of the key players competing in the personalized cancer drugs market are F. Hoffmann-La Roche Ltd., Pfizer Ltd., Cell Therapeutics, Inc., H3 Biomedicine, Inc., bioTheranostics, GlaxoSmithKline, and Abbott Laboratories. Zelboraf (vemurafenib) by F. Hoffmann-La Roche Ltd. and Xalkori (crizotinib) by Pfizer Ltd. are some notable targeted drugs for the treatment of cancer.

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Genetically modified mosquitoes could be released in Florida this summer – WFLA

July 2nd, 2020 1:47 pm

(THE CONVERSATION) This summer, for the first time, genetically modified mosquitoes could be released in the U.S.

On May 1, 2020, the company Oxitec received anexperimental use permitfrom the U.S. Environmental Protection Agency to releasemillions of GM mosquitoes(labeled by Oxitec as OX5034) every week over the next two years in Florida and Texas. Females of this mosquito species, Aedes aegypti, transmit dengue, chikungunya, yellow fever and Zika viruses. When these lab-bred GM males are released and mate with wild females, their female offspring die. Continual, large-scale releases of these OX5034 GM males should eventually cause the temporary collapse of a wild population.

However, as vector biologists, geneticists, policy experts and bioethicists, we are concerned that current government oversight and scientific evaluation of GM mosquitoes do not ensure their responsible deployment.

Genetic engineering for disease control

Coral reefs that can withstand rising sea temperatures,American chestnut treesthat can survive blight andmosquitoes that cant spread diseaseare examples of how genetic engineering may transform the natural world.

Genetic engineering offers an unprecedented opportunity for humans to reshape the fundamental structure of the biological world. Yet, as new advances ingenetic decodingandgene editingemerge with speed and enthusiasm, the ecological systems they could alter remain enormously complex and understudied.

Recently, no group of organisms has received more attention for genetic modification than mosquitoes toyield inviable offspringor make themunsuitable for disease transmission. These strategies hold considerable potential benefits for the hundreds of millions of people impacted bymosquito-borne diseaseseach year.

Although the EPA approved the permit for Oxitec, state approval is still required. A previously planned release in the Florida Keys of an earlier version of Oxitecs GM mosquito (OX513) waswithdrawn in 2018aftera referendum in 2016indicated significant opposition from local residents. Oxitec has field-trialed their GM mosquitoes inBrazil, the Cayman Islands, Malaysia and Panama.

Thepublic forumon Oxitecs recent permit application garnered 31,174 comments opposing release and 56 in support. The EPA considered these during their review process.

Time to reassess risk assessment?

However, it is difficult toassess how EPA regulatorsweighed and considered public comments and how much of theevidence used in final risk determinationswas provided solely by the technology developers.

The closed nature of this risk assessment process is concerning to us.

There is a potential bias and conflict of interest when experimental trials and assessments of ecological risk lackpolitical accountabilityand are performed by, or in close collaboration with, the technology developers.

This scenario becomes more troubling with afor-profit technology companywhen cost- and risk-benefit analyses comparing GM mosquitoes to other approachesarent being conducted.

Another concern is thatrisk assessmentstend to focus on only a narrow set of biological parameters such as the potential for the GM mosquito to transmit disease or the potential of the mosquitoes new proteins to trigger an allergic response in people and neglect other importantbiological,ethicalandsocialconsiderations.

To address these shortcomings, the Institute for Sustainability, Energy and Environment at University of Illinois Urbana-Champaign convened a Critical Conversation on GM mosquitoes. The discussion involved 35 participants from academic, government and nonprofit organizations from around the world with expertise in mosquito biology, community engagement and risk assessment.

A primary takeaway from this conversation was an urgent need to make regulatory procedures more transparent, comprehensive and protected from biases and conflicts of interest. In short, we believe it is time to reassess risk assessment for GM mosquitoes. Here are some of the key elements we recommend.

Steps to make risk assessment more open and comprehensive

First, an official, government-funded registry for GM organisms specifically designed to reproduce in the wild and intended for release in the U.S. would make risk assessments more transparent and accountable. Similar to the U.S.database that lists all human clinical trials, this field trial registry would require all technology developers to disclose intentions to release, information on their GM strategy, scale and location of release and intentions for data collection.

This registry could be presented in a way that protects intellectual property rights, just as therapies entering clinical trials are patent-protected in their registry. The GM organism registry would be updated in real time and made fully available to the public.

Second, a broader set of risks needs to be assessed and an evidence base needs to be generated by third-party researchers. Because each GM mosquito is released into a unique environment, risk assessments and experiments prior to and during trial releases should address local effects on the ecosystem and food webs. They should also probe the disease transmission potential of the mosquitos wild counterparts andecological competitors, examine evolutionary pressures on disease agents in the mosquito community andtrack the gene flowbetween GM and wild mosquitoes.

To identify and assess risks, a commitment of funding is necessary. The U.S.EPAs recent announcementthat it would improve general risk assessment analysis for biotechnology products is a good start. But regulatory and funding support for an external advisory committee to review assessments for GM organisms released in the wild is also needed;diverse expertise and local community representationwould secure a more fair and comprehensive assessment.

Furthermore, independent researchers and advisers could help guide what data are collected during trials to reduce uncertainty and inform future large-scale releases and risk assessments.

The objective to reduce or even eliminate mosquito-borne disease is laudable. GM mosquitoes could prove to be an important tool in alleviating global health burdens. However, to ensure their success, we believe that regulatory frameworks for open, comprehensive and participatory decision-making are urgently needed.

This article was updated to correct the date that Oxitec withdrew its OX513 trial application to 2018.

[Deep knowledge, daily.Sign up for The Conversations newsletter.]

This article is republished from The Conversation under a Creative Commons license. Read the original article here:https://theconversation.com/genetically-modified-mosquitoes-could-be-released-in-florida-and-texas-beginning-this-summer-silver-bullet-or-jumping-the-gun-139710.

The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.)

Brian Allan,University of Illinois at Urbana-Champaign;Chris Stone,University of Illinois at Urbana-Champaign;Holly Tuten,University of Illinois at Urbana-Champaign;Jennifer Kuzma,North Carolina State University, andNatalie Kofler,University of Illinois at Urbana-Champaign

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Outlook into the Cell Culture Protein Surface Coating Global Industry to 2025 – Featuring PerkinElmer, Promega & Qiagen Among Others -…

July 2nd, 2020 1:46 pm

DUBLIN--(BUSINESS WIRE)--The "Cell Culture Protein Surface Coating Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2020-2025" report has been added to ResearchAndMarkets.com's offering.

The global cell culture protein surface coating market is currently experiencing strong growth. Looking forward, the publisher expects the market to grow at a CAGR of around 12% during 2020-2025.

A cell culture protein surface coating helps in enhancing the adhesion and proliferation of different cells, such as leukocytes, neurons, epithelial and fibroblasts, in vitro isolation and cultivation process.

The inner surface of a flask or petri dish is generally coated with extracellular matrix or proteins like laminin, collagen, fibronectin and vitronectin. Cell culture enables researchers to grow animal or plant cells in a favorable artificial environment, which further assists in understanding the roles of proteins in cell attachment, migration and function. It also aids in developing model systems for research, studying cellular functions, stem cell research, drug discovery and genetic engineering.

Owing to the growing prevalence of chronic diseases, the interest of scientists and various biotechnology companies in cancer and stem cell research is escalating around the world. Stem cells are effective in treating cancer, brain diseases, cell deficiency therapy, and cardiovascular diseases. This represents one of the significant factors, which is strengthening the global cell culture protein surface coating market growth.

Apart from this, the adoption of 3D cell cultures has increased in recent years, which has also contributed to market growth. A 3D cell culture refers to a process that assists in growing biological cells in a controlled environment, wherein these cells can interact with their surroundings. Furthermore, inflating income levels and increasing healthcare expenditures are projected to strengthen the market growth in the upcoming years.

Companies Mentioned

Key Questions Answered in this Report:

Key Topics Covered:

1 Preface

2 Scope and Methodology

3 Executive Summary

4 Introduction

4.1 Overview

4.2 Key Industry Trends

5 Global Cell Culture Protein Surface Coating Market

5.1 Market Overview

5.2 Market Performance

5.3 Market Forecast

6 Market Breakup by Protein Source

6.1 Animal-derived Protein

6.2 Human-derived Protein

6.3 Synthetic Protein

6.4 Plant-derived Protein

7 Market Breakup by Type of Coating

7.1 Self-Coatings

7.2 Pre-Coatings

8 Market Breakup by Application

8.1 Scientific Research

8.2 Industrial Production

9 Market Breakup by Region

9.1 North America

9.2 Asia Pacific

9.3 Europe

9.4 Latin America

9.5 Middle East and Africa

10 SWOT Analysis

10.1 Overview

10.2 Strengths

10.3 Weaknesses

10.4 Opportunities

10.5 Threats

11 Value Chain Analysis

12 Porters Five Forces Analysis

12.1 Overview

12.2 Bargaining Power of Buyers

12.3 Bargaining Power of Suppliers

12.4 Degree of Competition

12.5 Threat of New Entrants

12.6 Threat of Substitutes

13 Price Indicators

14 Competitive Landscape

14.1 Market Structure

14.2 Key Players

14.3 Profiles of Key Players

For more information about this report visit https://www.researchandmarkets.com/r/v7pik4

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Outlook into the Cell Culture Protein Surface Coating Global Industry to 2025 - Featuring PerkinElmer, Promega & Qiagen Among Others -...

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The Future of Sports – Bleacher Report

July 2nd, 2020 1:46 pm

Each night, around 7 o'clock, I drift off into a little daydream. This has been the case for weeks now. My beloved Mets are jogging onto the grass at Citi Field, taking their positions; their ace, Jacob deGrom, making a beeline to the mound. I am up out of my seat, applauding, gazing out onto the field. I look up to the sky, and that's it, really. The scene tends to slip away from there. I look down to see the gates of my apartment's window guard and the emptied streets of Manhattan beyond them. I really am clapping, but it's got nothing to do with baseball. It's in support of local nurses and doctors at work or changing shifts. Across New York City, this ritual plays out night after night (the clapping for health care workersnot the Mets fantasies, I don't think).

There's a crossing of wires at play, like my precious sports memories are mingling with the signatures of my life during the COVID-19 eraclapping, quarantining, boredom. Will it stay this way? For a while, at least, I think it will.

As MLB, the NBA and other leagues near their returns, I find myself fascinated by questions pertaining to the virus and the ways it will ripple through our leagues. How many players will contract it? How will leagues' models evolve as they move forward? Even for mea lifelong overcommitted fan who sends excessive, neurotic text threads (unresponded to) during regular-season gamesI think most of the drama in sports will come not from daily games but from daily tests results. This is the virus overpowering the once-invincible sports machine.

Already, so much of the mystique of sports has been lost. I miss the steady, circular rhythm of leagues in-season, the way they appeared day after day, overlapping only a few sacred times a year as if choreographed by the moon instead of computers and marketing teams. I miss the shameless self-importance of teams playing no matter what. (Spring training continued for 10 days after the first cases of COVID-19 appeared in Florida.) It was simply more fun back when we could view athletes as impervious superheroes rather than as bored video-gamersor, worse, as medical patients. There is something uncomfortable about having seen a dominant, intimidating player like Rudy Gobert briefly exposed as reckless and unhygienic. Games will return soon enough, but what about the underlying myths that lend them relevance and depth?

The NBA's bubble-based return, set for July 30, cuts against team fandomso driven by proximityby moving everyone to Disney World. It admits that the game could go on without us, the fans, rowdy old faithful, by playing in near silence. Game rules are changing, too, yielding to the virus' demands. There are smaller coaching staffs to protect older people from exposure, and expanded rosters for when the inevitable happens. Every league is making compromises: MLB might ban its most endearing prop, the sunflower seed, and tweak its most fundamental, unique feature, the nine-inning game.

These leagues are right to weigh these measures and to take them. They are preventing tragedies, not creating them. But the bending of tradition makes me wonder about the future of sports, about how things just changed overnight, and how they might change again in 10 years or 50. Maybe that will be the enduring impact of COVID-19 when it comes to sportsthat it opened the gates to change.

Naturally, this is where things get strange. Stick it out anyway. Consider the ways that fans and leagues are already adapting to this odd time, this time of no sports, and then imagine what comes next, and what after that. One small bit of innovation leads to an unpredictable new one, and on it goes. Very quickly, this evolution brings us into the realm of science fiction.

We might be there already. While games were on hold, the public embraced something that in the past seemed both silly and dystopian: game simulations. Las Vegas offered sim-game betting lines; we hosted virtual Madden watch parties right here at B/R. They were and are an obvious placeholder for real sports. Still, their popularity made me curious about their power down the road, if animated graphics improve enough to match real sports. Technologically speaking, could that day be coming? I asked an expert.

Nicholas Bostrom is a professor at Oxford and a pioneer of the simulation theory, which posits that we may be living in a knockoff version of Earth created by a more advanced (real-life) society. (Assuming that computers will someday be able to produce unlimited realistic simulations of life, we might be wise, he suggests, to already "think that we are likely among the simulated minds rather than among the original biological ones.") Bostrom published Are You Living in a Computer Simulation? way back in 2003. Today, few are better equipped to tell us about the future of sims. So, Professor, how good can they get?

"Eventually we will have completely realistic virtual reality simulations that would be indistinguishable from physical reality," he says. "I don't see why in theory you couldn't have a purely artificial creature that was competing against another in a way that would create a sports event."

You might be wondering what the point of this would be once sports return. Well, consider the NBA's most exhausting debate topic: load (or injury) management. Back when there were regularly scheduled games, we wasted much time meditating on the notion of, say, Kawhi Leonard taking a night off, letting his teammates dominate the lowly Cavaliers or Knicks in front of a crowd that paid to see him play. It's obvious that if there were fewer games, the need to skip some of them would decrease. Fewer games would also soothe another of the league's concerns: players' lack of sleep amid a busy travel schedule.

Simulations could merge these issues and resolve them at once. Why not simulate lopsided games like Clippers-Cavs, providing rest for Leonard and everybody else involved? Each year, each team could sim 10 or 12 games, allowing a 70- or 72-game schedule for playersalready a desired ballparkand a full 82-game slate for the league's partners, like TV networks and casinos, who would package the simulated visuals and box scores.

Maybe this idea seems a little far out, but the NBA rarely minds. It is already welcoming the ideas of the future, from the four-point shot to aerospace revolution.

Indeed, Commissioner Adam Silver has long seen supersonic flight as the key to a truly global league. With it, Portland could face Sydney and return four hours later, in time for bed. We already have an Atlantic Division with teams from America's Northeast; how about adding a Transatlantic Division featuring Brazil, Spain and Nigeria? For now, the problem is a logistical one. "Under existing airline technology, the planes aren't fast enough to at least play in the current framework of our regular season," Silver told USA Today in 2017. Fortunately, with help from Elon Musk, Richard Branson and more, supersonic jets are on their way. Just one of many game-changers to come.

Robots have perfected three-point shooting and will someday make flawless floor-spacers. Salaries paid in cryptocurrency will provide a cap loophole and threaten the league's financial structure. Augmented reality on-screen willsomehowincrease complaints about players' shot selection. Advanced tracking through biometric data will grow into a major concern regarding personal privacy. How much should bidding teams know about a free agent's body? Who gets to dictate the right body fat percentage for somebody else or whether a balky ankle is strong enough to play on? And, as the Wall Street Journal once asked: If a fan gains access to a player's medical status and uses it to wager on a game, is that insider trading? (If the answers to these questions seem like a privacy violation, then consider how quickly athletes' COVID-19 test results became expected public information, even though they're irrelevant so long as sports are on hold. If there is already a demand to know whether Ezekiel Elliott, a running back, is experiencing an inability to smell, then there's no doubting the future demand for intimate insight about his legs.)

Yes, the future can seem vast and spookythough not to Thomas Frey. Frey is an author and member of the Association of Professional Futurists. His job is to burst with ideas, and he's bursting all right, riffing on the future of medicine, tech, sports, you name it. He envisions not only the events of the future but also the issues that will counter those eventsthe future's future. "Drone racing is kind of a hot area right now," he says, "but my sense is that the drone racing eventually gets so fast that you can't even see it, and so I'm not sure that sport sticks around." Dang. What else? Frey wants to elevate existing sportsthe ones played on the groundthrough the control and reduction of gravity. (Think NFL meets Quidditch or Slamball with no need for trampolines.) He wonders about anti-aging, tooin this case, what 3,000-year lifespans might mean for athletic primes.

Other revolutions are impossible to imagine playing out (unless you happen to be a member of the APF). "We're close to reviving extinct species like woolly mammoths," Frey notes, before pondering the cruelty of secluding them from other, natural-born animals. An idea strikes him. "Creating a sport with woolly mammoth riders going around the trackthat would seem bizarre today," he says. "But I would definitely pay to go see that."

Of course, there is not only the matter of tweaking (or inventing) sports, but also that of tweaking the players themselves. One of Frey's favorite topics is genetic engineeringthe process of tinkering with human genes before birth. "We're reinventing people. We're making people more durable. We're giving rights to CRISPR [the bio-tech giant], who will give us superbabies who grow up to be superhumans," he says. OK then. Frey thinks it's inevitable that, someday, we'll be able to genetically manufacture superior athletes: bigger, faster, smarterto an uncanny degree. He wonders about "downloading the human brain" and uploading it into the mind of another person. In time, if this all gets easy and silly enough, a supertoddler could have the basketball IQ of LeBron James. (Just imagine the recruiting violations that would follow.)

Bostrom has explored genetic engineering as well. "The enhancement options being discussed," he wrote in 2003, "include radical extension of human health-span, eradication of disease, elimination of unnecessary suffering" and more. A superhuman ability to ward off illnesssay, a coronaviruswould certainly come in handy. So too would advancements that eliminate athletic limitations. Imagine how a perfect set of knees would have changed the careers of Greg Oden, Brandon Roy and others; imagine Shaquille O'Neal with a sprinter's endurance; imagine Jimmer Fredette at 7'3".

Sounds pretty greator actually it sounds like it would look pretty great, visually. But would this be good for sports? Is it ethical? Or the right spirit? And how would this impact the lives of the athletes we love?

Every tech innovation takes something away from the humans it replaces or (ostensibly) aids. Flawless three-and-D bots entering the NBA would not only change the game but also eliminate dozens or hundreds of lucrative jobs. Supersonic travel, alluring as it may be, could have untold effects on passengersespecially international-league athletes, flying overseas day after day. Genetic engineering could draw a devastating, permanent line between the haves and the have-nots.

When it arrives in full force, Frey says, crafting a given attribute"20/10 vision, a perfect heart"may well cost tens of thousands of dollars. There's no telling what else will be at the disposal of fortunate young athletes then (though Frey, of course, has some ideas, including advanced VR headsets).

Already, financial inequality pervades all of sports. Young basketball players need to be able to cover the costs of trainers and AAU travel teams to earn recognition; it's probably not a coincidence that the children of well-off former players are entering the league at a higher rate than ever. Young baseball players need not only training but also equipment, toomitts, balls, bats, helmets, cleats. (Cleveland pitcher Mike Clevinger recently blamed these costs for the sport's declining popularity among young athletes.) Golf, football, hockeyevery major sport operates behind a financial barrier to entry. In 2018, The Atlantic noted that "just 34 percent of children from families earning less than $25,000 played a team sport at least once a day in 2017, versus 69 percent from homes earning more than $100,000." (Those numbers came from a study by the Aspen Institute, which found that the gap was rapidly growing.)

Imagine a world in which the NBA MVP is an 8'6" trust-fund kid. It seems awfully shallow. Could a souped-up superhuman celebrate the award with the same tenderness as Kevin Durant did in 2014? Even if they did, would we bother to cry along with them? There is no great story in sports without long odds and a dash of relatability.Genetic engineering would destroy the enduring notion of the underdog. It would dull the sweetness of our games, the unpredictability, the misery, the reward. What, then, would be left?

"I'm not particularly excited about sports enhancements," Bostrom says, speaking broadly. "We shouldn't make the mistake of thinking everything that makes the sport easier or makes performance better makes the sport more enjoyable. I think we should think of these things more as, You're designing a game. Think creatively about what would make the most fun game. It's not always the easiest thing."

So far, leagues have mostly welcomed new tech as it arrives, a concerning trend. Consider the modern obsession with instant replay.

Think back to the men's NCAA title game last April. With the season on the line, the ball was knocked out of a Texas Tech dribbler's hands and flew out of bounds. For anybody who has ever picked up a basketball and played a game on any level, it was instantly recognizable as Tech's ball. But after several minutes of replaywhich included referee consultant Gene Steratore saying, "At times, guys, I will tell you, when you start running replay really, really slow, you get a little bit of distortion in there as well, so you've gotta be cognizant to that," suggesting that looking more closely may bring us further from the truththe ball was given to Virginia, the underlying logic being that the most important thing is to get the call right. Is it? What about the flow of the game, the sanity of the viewer, the unspoken understandingsI knocked it out; it's your ballthat run between players and fans, deepening the sport?

This, I will always believe, is the good stuff. Even Bostromwho is so technical that he at one point connects sports fandom to ancient Greek war and says, "You can speculate that, from an evolutionary point of view, being able to detect small differences in fitness would be valuable"agrees these intangibles are worth protecting. Even at the cost of, say, letting simulations run wild.

"You can't predict how an actual game will play out just by sort of measuring the circumference of the biceps and the speed on the treadmill of the athletes," Bostrom says. "And I think if you could predict it, in some sense it could reduce interest. It's not the same as seeing the struggle, the human spirit, the grit, the audience cheering them on."

The question, then, is not so much whether replay or sims or any other technical advance are helpful or efficient but whether we have the ability to recognize when they are aiding sports versus when they are harming them, and when the time is right to rein them in.

"Rather than just allowing everything that makes the performance better," Bostrom says, "we should think more about changes that make the game more fun and rewarding for both the players and the audience."

Are we doing this now? It's hard to say. The COVID-19 pandemic is accelerating change and the acceptance of change. It is clouding the rule-changing thought process. Already, long-standing traditions and powerful illusions have been altered across sports. After years of debate within baseball about the designated hitter, it will be implemented leaguewide as part of MLB's plan for a safe return. It is but a footnote to a much more complex story, which is fine. But also, how does the DH protect anybody from the coronavirus?

The NBA's bubble league will introduce its own oddities, though not everyone will be there to experience them firsthand. Several players have already tapped out of the NBA reboot, some fearing the virus, some having tested positive for it, some unwilling to separate from their loved ones. Others are sitting out so they can focus on social justice reform after expressing concerns that basketball could detract from those efforts. For those traveling to Disney World, it will be a lonely undertaking. Players themselves "are not permitted to enter each other's hotel rooms." Card games, if they do occur, will be monitored closely, and decks will be swapped out frequently.

Every league is drawing its own unprecedented game plan. The NFL is planning to cover the seats closest to the sidelines to keep fans away from players (though the league of course will advertise on the tarp). The NHL will reportedly route its action through two hub cities, Toronto and Edmonton. The measures that college sports will need to takeassuming anybody is on campus come Septemberfigure to be the most drastic of all.

Tech innovation will accompany each return: temperature screenings, artificial crowd noise, broadcasting from home. As quarantine warps our collective sense of time, it feels as though we've known these quirks forever. But not long ago they would have seemed quite strange, impossible, unwelcome, like somebody somewhere out there was toying with our settings.

Leo Sepkowitz joined B/R Mag in 2018. Previously, he was a Senior Writer at SLAM Magazine. You can follow him on Twitter: @LeoSepkowitz.

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Viewpoint: Conservation isn’t enough. We need technology to blunt the impacts of climate change – Genetic Literacy Project

July 2nd, 2020 1:46 pm

As a species, humans are fortunate in their adaptive capacity. The technologies that make us better equipped to live in a warming world heating, air conditioning, drinking water infrastructure, and the like are part and parcel to modernity, accessible to much, though still too little, of the global population. While we can expect these technologies to become more widespread in emerging economies, there will certainly be a multitude of socioeconomic and political challenges to overcome.

Non-human nature, by contrast, is sharply limited in its capacity to adapt to climate change, and even the best-case mitigation scenarios will put massive pressure on ecosystems. In a 2C world, a full25 percentof species are at risk of regional extirpation (double that in a 4.5C world). Already, climate-related local extinctions have occurred in hundreds of species. These impacts are terrifying and poorly understood. There have been and will continue to be ecosystem thresholds that we cant predict such as the massive pine beetle outbreaks that decimated drought-stricken western forests and biodiversity loss could be worse than projected.

The time is ripe for a conversation about how humans could help adapt the natural world through more direct forms of intervention, a conversation that does not sit comfortably with the values of traditional environmentalism, which regard such intervention with reflexive wariness.

To date, the conservation community has been understandably focused on protecting habitat and reducing emissions to shield non-human life from the impacts of climate change. And while adaptation in the natural world is not a new concept there have beennumerous studies and recommendationsmade in this space direct, technology driven interventions such as translocation, genetic modification, biocontrols, and the use of human infrastructure to support ecosystems have not been part of the mainstream conversation.

Traditional conservation approaches are no longer enough

Climate change will amplify ecosystem stressors like disease, habitat degradation, and invasive species, and indeed already has. Research shows that the effectiveness of disease resistance genes may vary depending on the climate.Big blue-stem, the dominant grass species in tallgrass prairie ecosystems, had higher infection rates when exposed to larger but more infrequent precipitation events, and longer periods of drought. Pathogens may also shift their range as a result of changing conditions, as may also be true ofneedle blight, a fungal disease that impacts ponderosa pine.

Restoring degraded habitat is becoming more challenging as a result of climate change.Elkhorn Slough National Estuarine Research Reserve, one of the largest tracts of tidal salt marsh on the West Coast, is the subject of ongoing research to determine the most effective way to restore and maintain the landscape in the face of sea level rise.

Invasive species are another threat being amplified by climate change. Many invasives are able to spread faster as the growing season is extended by earlier spring snowmelt and later fall frost onset. These harmful species are sometimes better able to match shifts in season timing than native species,for example, the invasive plant speciespurple loosestrifeis now blooming in Massachusetts much earlier than its native counterparts. This resilience can be a serious problem as it enhances the ability of invasives to outcompete native species.

On top of amplifying existing stressors, climate change is also triggering more direct impacts in especially vulnerable ecosystems. Already, the majority of tropical coral reefs are projected tosuffer significant losseseven if global warming is limited to 1.5C. The Great Barrier Reef suffered unprecedented bleaching events in 2016 and 2017, whichdamaged two thirdsof the reef, and is in the midst ofyet another the third in five years leaving little time for recovery.

Likewise, kelp forests are being decimated by aseries of connected eventstriggered by warming temperatures. These ecosystems already weakened by marine heatwaves are being devoured by booming populations of sea urchins, precipitated by warmer waters. In northern California, more than 90 percent of bull kelp was lost along 217 miles of coastline, and huge losses have also occurred off the coast of Japan, the Aleutian Islands, and Tasmania.

We need to employ intentional and direct interventions in addition to existing strategies to ensure we pursue every opportunity to prevent biodiversity loss.

Extensive terrestrial impacts are occurring as well. Globally, insect populations have plummeted, and worsening climate change could mean some40 percentof all insect species could go extinct in the coming decades. This will negatively impact the numerous insectivores that depend on them as a food source, and it threatens agricultural sectors dependent on pollinators.

While mitigating climate change and minimizing these existing stressors will be critical first steps to ensuring ecosystems are best able to withstand the worsening impacts of climate change, they are no longer enough to counter the magnitude of the threat. We need to employ intentional and direct interventions in addition to existing strategies to ensure we pursue every opportunity to prevent biodiversity loss.

Translocation

As climate change begins to shift habitats and change the range that species occupy, protected lands and wildlife corridors though critical tools wont always be sufficient. While some species are able to traverse rugged landscapes and cover vast distances, the same cannot be said for many other plants and animals. Amphibians, small mammals, and other species that are endemic to isolated areas are especially vulnerable. If species are not able to naturally disperse as their ranges shift in a changing climate, wildlife managers may need to take a more active role in physically introducing them into new areas.

Historically, wildlife managers have focused on restoring species to their past ranges, and have reintroduced captive-bred individuals to boost endemic populations. But translocation can be used for more than these past practices. It can be used to move species that are unable to disperse naturally, or else can be used as a form of ecological correction by introducing a species to fill a void created by a local extinction of a different species.

The practice is controversial, as people worry that a translocated species will become invasive in its new habitat (or transfer new pathogens) and decimate the ecosystem as a result. Predator translocation is often the most expensive and controversial of these efforts, though it is also often one of the most valuable in terms of improving ecological health by controlling herbivore populations and slowing the spread of wildlife disease.

While there is a risk of unforeseen consequences, there have also been success stories. For example, in England,the marbled white butterflywas successfully translocated to previously unoccupied habitat and was able to establish a viable population without impacting other endemic species. And theAldabra giant tortoisewas introduced to Mauritian islands to replace an extinct Mauritian tortoise species and successfully fulfilled the same seed-dispersal and vegetation-control role the original species filled.

Genetic modification

Restoration efforts will be limited as a result of climate change. Setting funding aside for restoring sand dunes damaged by hurricanes and forests damaged by wildfires will help. But restoring ecosystems to their previous state may no longer be sufficient in some areas. As impacts worsen and vulnerable species are not able to adapt quickly enough on their own, scientists may be able to prevent local extinctions by intervening via genetic modification either through genetic selection or engineering.

TheAmerican Chestnutis a paradigmatic example of a species that will most likely requiregenetic modificationbefore recovery efforts can be successful. These trees once grew up to 100 feet tall and had 10 foot diameter trunks. But in the early 1900s an imported fungus decimated the native Eastern chestnut forests wiping out 99.9 percent of the species and over 100 years later the species still hasnt recovered. That may change. By inserting a gene from wheat into a wild chestnut embryo, scientists are striving to give the vulnerable trees the ability to produce enzymes that detoxify the fungus, and these efforts have already begun to prove successful as modified experimental trees are able to withstand infection.

The black-footed ferret, another example, is extremely vulnerable to Sylvatic plague and suffers from a severe lack of genetic diversity. While captive breeding programs have been successful, these limitations make it difficult to establish populations in the wild. Genetic modification may make it possible to reintroduce lost genetic diversity and convert the vaccine for the Sylvatic plague into a permanent inheritable trait.

Genetic modification offers a host of opportunities to strengthen species that are being wiped out by worsening climate impacts as well. In forested areas damaged by bark beetle outbreaks and severe fires, it would be more effective to reforest with trees that are genetically predisposed to withstand infestations (or drought, or disease, depending on the threats identified in the region). Similar strategies are being employed across many tropical reefs, as scientistscultivate resilient lines of coralin the hopes that they will prove more resistant to the warmer temperatures and increased ocean acidification.

Such strategies could help ensure restoration investments are more secure against future impacts, highlighting the need for the field of conservation genetics as a backstop to the risk of future extinctions. Scientists can bank genetic material, map genomes, and reprogram tissue culture cells for genetic rescue efforts. TheSan Diego Zoo Institute for Conservation Researchhas a genetic bank with over 10,000 living cell cultures, oocytes, sperm, and embryos representing nearly 1,000 taxa, and theSvalbard Global Seed Vaultholds over one million seed varieties in order to protect cultivated and wild plant biodiversity.

Human made infrastructure to support ecosystem function

Human infrastructure also has a role to play in conservation, especially for helping species adapt to changing precipitation patterns. In areas where changing precipitation patterns lead to more extreme rainfall events, certain manmade infrastructure can help manage runoff in order to avoid soil erosion in sensitive habitats, and can help protect the habitat of vulnerable species. For example, albatross in Tasmania are struggling to survive as chicks are killed bywarmer temperaturesand nests are washed away by sea-level rise and more frequent and severe precipitation events. Scientists are transportingartificial nestsmade of concrete and coconut fiber by helicopter to the nesting sites in order to increase the chicks chances of survival. So far, scientists have found that pairs using the artificial nests had a 20 percent higher success rate than those using natural nests.

In ecosystems hit especially hard by drought we may be able to transport additional water to help maintain function. InKenya, arid landscapes are predisposed to extended periods with little precipitation, but climate change is exacerbating poor land management to extend these dry periods even further which could spell disaster for vulnerable wildlife. Further, lack of water increases conflict between wildlife and people as ranchers struggle to support their own herds. By installing boreholes, water pipes, strategic dams, and other human made infrastructure to bring water from aquifers to the surface and manage current supply, land managers can help ensure wildlife are able to survive changing precipitation patterns.

Biocontrols

Failed biocontrol efforts are often given as cautionary tales against ecosystem intervention. In the early 2000s, the US releasednon-native beetlesto control the spread of an invasive plant called tamarisk. At the time, managers believed the beetle would only inhabit a limited range and would not be able to disperse widely an assumption that proved untrue. The beetle did spread, with the unforeseen cost of decimating the habitat of the endangered southwestern willow flycatcher. There are numerous other stories, such as the extreme failures of cane toad introduction in Australia, and mongoose introduction in Hawaii.

But while there are risks associated with biocontrol interventions, there have also been remarkable success stories. The gypsy moth, which was first brought to the US to breed with the native silkworms, escaped through an open lab window in 1868 and began to decimate deciduous trees across North America. Afungus, found to infect the moths, was discovered in Japan and brought back to the US, and eventually a strain of the fungus was found to effectively spread through the moth population. A coordinated program calledSlow the Spread Program (STS)was funded by Congress in 2000 and has reduced the spread of gypsy moths by more than 70 percent.

Using pathogens and predator species to control the increased spread of invasive species in the face of a changing climate raises several red flags. The thought of a disease jumping host species is almost as frightening as climate change itself, especially given the rapid spread of COVID-19, which scientists believe originated in a live animal market. But biocontrols have been used extensively in agriculture, and highly specialized pathogens and predator species are unlikely to expand beyond the intended target. Scientists are continuing to look for new tools to expand the use of biocontrols beyond the agriculture sector to the natural environment.

Expanding options for conservation

Healthy ecosystems increase human adaptive capacity. Healthy insect populations support the agriculture sector, healthy wetlands provide flood control and clean water, healthy forests provide stable long term carbon storage, and healthy oceans offer a critical source of protein for many developing countries. But as we observed above, humans are unique in our capacity to augment ecosystem services via direct, technology-driven interventions, which is why the impacts of climate change pose a far greater threat to wildlife and ecosystems than to people. Imported pollinators, engineered water infrastructure, and farmed seafood are just a few examples. We have only dimly begun to conceptualize the adaptive limits of the natural world, but we should employ all available tools to protect not just ourselves, but our non-human neighbors.

Lauren Anderson is a climate and energy analyst at the Breakthrough Institute. Follow her on Twitter @LaurenRAnders1. Zeke Hausfather is the Director of Climate and Energy at the Breakthrough Institute. Follow him on Twitter @hausfath

This article was originally published at the Breakthrough Institute and has been republished here with permission. Follow the Breakthrough Institute on Twitter @TheBTI

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Global Genome Editing/Genome Engineering Market 2020 By Components, Application, Leading Players, Industry Updates, Business Prospects, Forthcoming…

July 2nd, 2020 1:46 pm

The Global Genome Editing/Genome Engineering Market report offers users the detailed study of the market and its main aspects. There are different marketing strategies that every marketer looks up to in order to ace the competition in the Global market. Some of the primary marketing strategies that is needed for every business to be successful are Passion, Focus, Watching the Data, Communicating the value To Your Customers, Your Understanding of Your Target Market. There is a target set in market that every marketing strategy has to reach. Some of the important aspects analyzed in the report includes market share, production, key regions, revenue rate as well as key players. This Genome Editing/Genome Engineering report also provides the readers with detailed figures at which the Genome Editing/Genome Engineering Market was valued in the historical year and its expected growth in upcoming years. Besides, analysis also forecasts the CAGR at which the Genome Editing/Genome Engineering is expected to mount and major factors driving markets growth.

This study covers following key players:Thermo Fisher ScientificMerckHorizon DiscoveryGenscriptSangamo BiosciencesIntegrated Dna TechnologiesLonzaNew England BiolabsOrigene TechnologiesTransposagen BiopharmaceuticalsEditas MedicineCrispr Therapeutics

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A significant development has been recorded by the market of Genome Editing/Genome Engineering, in past few years. It is also for it to grow further. To analyze the Global Genome Editing/Genome Engineering Market, the analysis methods used are SWOT analysis and PESTEL analysis. To identify what makes the business stand out and to take the chance to gain advantage from these findings, SWOT analysis is used by marketers. Whereas PESTEL analysis is the study concerning Economic, Technological, legal political, social, environmental matters. For the analysis of market on the terms of research strategies, these techniques are helpful. Various important factors such as market trends, revenue growth patterns market shares and demand and supply are included in almost all the market research report for every industry.

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Market segment by Type, the product can be split intoCRISPRTALENZFN

Market segment by Application, split intoCell Line EngineeringAnimal Genetic EngineeringPlant Genetic Engineering

A systematized methodology is used to make a Report on the Global Genome Editing/Genome Engineering Market. For the analysis of market on the terms of research strategies, these techniques are helpful. All the information about the Products, manufacturers, vendors, customers and much more is covered in research reports. The market tends to be highly competitive in nature as the number of vendors present in the market is too high.

The Genome Editing/Genome Engineering market has its impact all over the globe. On Global Genome Editing/Genome Engineering industry is segmented on the basis of product type, applications, and regions. It also focusses on market dynamics, Genome Editing/Genome Engineering growth drivers, developing market segments and the market growth curve is offered based on past, present and future market data. The industry plans, news, and policies are presented at a Global and regional level.

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Soon we’ll be able to engineer the wild, can the policies keep up with the science? | TheHill – The Hill

July 2nd, 2020 1:46 pm

Humans have been able to genetically alter the world around them for thousands of years. With the domestication of dogs at least 14,000 years ago, genetically modified organisms (GMOs) have been a constant feature of human society; only recently have we gained the ability to perform these modifications at the molecular level.

Even more recently, gene drive technology has fundamentally added the ability of humans to modify wild organisms, not only domesticated organisms. With the ability to make rapid, permanent changes to wild species on the near horizon, we must act now to implement policies that will carefully regulate their use while allowing for vital scientific research to continue.

While GMOs have become fundamental to the farming industry, they always have the same limitation: they must be protected and maintained on farms, in pens, or other human-maintained environments. If released into the wild, GMOs find themselves out-competed by their naturally occurring cousins, since genetic modifications made to suit human tastes (think seedless watermelons) typically have a hard time surviving in the wild. An exception to this rule is the survival of invasive species when introduced into a different environment and have no natural competition in their new habitat.

Gene drive technology now makes it possible for humans to engineer species that are currently and will remain, wild such as the mosquito. Gene drive engineering can create an artificial selective pressure to transmit the gene drive from parent to offspring at a higher rate than would naturally occur.

Eventually, offspring with the gene drive replace the unaltered form of the organism, an overwhelming natural section that would normally favor the unaltered form. This profoundly new capability makes gene drives different from GMOs which are not designed to replace wild organisms and do not have the capability to overtake wild populations if accidentally released.

Because gene drives, as tools for the management and engineering of species in the wild, are intrinsically different from GMOs, it is not adequate to regulate them like other GMOs or rely only upon the framework of existing GMO regulations. We need a series of policy goals to prevent missteps in the deployment of this powerful tool.

It is unlikely that gene drives will see direct use in agricultural crops and animals, despite the agricultural application being the main concern of gene drive opposers. Such cultivated species are already under de facto genetic control by farmers who decide which animals to breed and which seeds are sown. As such, a gene drive in farmed species would be a very expensive and complex way to achieve something already possible through conventional agricultural methods.

It is, however, quite likely that gene drives will soon be used to control malaria, either to suppress malaria-carrying mosquito populations or genetically alter them such that they are unable to transmit malaria to humans. Should this public health application prove to be safe and beneficial, further applications of gene drives may soon follow. Another near-term application could be to control agricultural pest species such as leafhoppers or aphids in order to improve crop yield.

The management of human-influenced species with gene drives presents a potential flashpoint where conflicting economic and environmental interests intersect. We define human-influenced species as those that live and breed wild but are harvested heavily by humans. In other words, humans do not actively alter the environment of these species for agricultural purposes, but human harvesting activities have direct and indirect impacts on their population dynamics. Oceanic fish are an example of human-influenced species. These fish may live and travel across international and national territorial waters, and thus the release of a gene drive in these species would result in significant and competing economic interests. The ability of genes to drive fish to move from jurisdiction to jurisdiction presents a unique problem to international biodiversity protocols.

With the first release of gene drives for malaria control is likely to occur within the next 5-10 years, there is a need for immediate national regulation of gene drives and a need for broad international harmonization of gene drive regulation. While great care has been taken by researchers to safely and ethically advance malaria control gene drive research, explicit regulation is required to mitigate risks from future efforts and to hold all deployable gene drives to appropriate standards.

As we have experienced during COVID-19 with poorly functioning antibody tests, a loose regulatory environment can lead to products entering the market that have not been properly validated. In the case of gene drives, a loose regulatory environment could lead to irreversible damage to wild ecosystems.

The U.S. government should create nationally-mandated tiered registries of gene drive research. Coordinated, nationally-mandated registries would allow for the fast adoption of clear gene drive documentation. In time, the multiple national registries can hopefully be harmonized into a single international registry. These registries should be tiered in such a way that gene drives that are closer to possible deployment must report more detailed information than research projects that are in the exploratory phase.

As projects approach deployment, public transparency and independent review become more important considering the potential for gene drives to radically alter a wild environment. To realize the potential benefits of this technology, we now must act practically, proactively, and carefully to regulate their progress from small-scale research all the way through large-scale deployment.

Michael Montague, Ph.D. is a senior scholar and Amanda Kobokovich, MPH is a senior analyst at the Johns Hopkins Center for Health Security at the Bloomberg School of Public Health. The authors recently published a report Gene Drives: Pursuing Opportunities, Minimizing Risk.

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New Insights Into the Impact of Stochasticity in Gene Expression – Technology Networks

July 2nd, 2020 1:46 pm

A team of quantitative biology researchers from Northwestern Engineering and the Weinberg College of Arts and Sciences has uncovered new insights into the impact of stochasticity in gene expression, offering new evolutionary clues into organismal design principles in the face of physical constraints.

In cells, genes are expressed through transcription, a process where genetic information encoded in DNA is copied into messenger RNA (mRNA). The mRNA is then translated to make protein molecules, the workhorses of cells. This entire process is subject to bursts of natural stochasticity or randomness which can impact the outcome of biological processes that proteins carry out.

The researchers' new experimental and theoretical analyses studied a collection of genes in Drosophila, a family of fruit flies, and found that gene expression is regulated by the frequency of these transcriptional bursts.

It has been known for almost two decades that protein levels can demonstrate large levels of stochasticity owing to their small numbers, but this has never been empirically demonstrated in multicellular organisms during the course of their development, said Madhav Mani, assistant professor of engineering sciences and applied mathematics at the McCormick School of Engineering. This work for the first time identifies the role of randomness in altering the outcome of a developmental process.

A paper outlining the work, titled The Wg and Dpp Morphogens Regulate Gene Expression by Modulating the Frequency of Transcriptional Bursts, was published in the journal eLife. Mani is a co-corresponding author on the study along with Richard Carthew, professor of molecular biosciences in the Weinberg College of Arts and Sciences. Both are members of Northwesterns NSF-Simons Center for Quantitative Biology, which brings together mathematical scientists and developmental biologists to investigate the biology of animal development.

This study builds upon a recent paper in which the researchers studied the role of stochastic gene expression on sensory pattern formation in Drosophila. By analyzing experimental perturbations of Drosophilas senseless gene against mathematical models, the team determined the sources of the genes stochasticity, and found that the randomness appears to be leveraged in order to accurately determine sensory neuron fates.

The researchers applied that understanding to this latest study using a technique called single molecule fluorescence in situ hybridization (smFISH) to measure nascent and mature mRNA in genes downstream of two key patterning factors, Wg and Dpp, responsible for the organ development of fruit fly wings. In comparing the measurements to their data models, the researchers found that, while each genes pattern of expression is unique, the mechanism by which expression is regulated which the team named burst frequency modulation is the same.

Our results show that proteins levels of randomness are impacted by the physical structure of the genome surrounding the gene of interest by modulating the features of the software that control the levels of gene expression, Mani said. We developed an experimental approach to study a large collection of genes in order to discern overall trends as to how the stochastic software of gene regulation is itself regulated.

The observed patterns of gene regulation, Mani said, works like a stochastic light switch.

Lets say you are quickly flipping a light switch on and off, but you want more brightness out of your bulb. You could either get a brighter bulb that produced more photons per unit time, or you could leave the switch on more than off, Mani said. What we found is that organisms control the amount of gene expression by regulating how often the gene is permitted to switch on, rather than making more mRNAs when it is on.

Carthew, director of the Center for Quantitative Biology, added that this mode of gene expression regulation was observed for multiple genes, which hints at the possibility of a broader biological principle where quantitative control of gene expression leverages the random nature of the process.

From these studies, we are learning rules for how genes can be made more or less noisy, Carthew said. Sometimes cells want to harness the genetic noise the level of variation in gene expression to make randomized decisions. Other times cells want to suppress the noise because it makes cells too variable for the good of the organism. Intrinsic features of a gene can imbue them with more or less noise.

While engineers are excited by the ability to control and manipulate biological systems, Mani said, more fundamental knowledge needs to be discovered.

We only know the tip of the iceberg, Mani said. We are far from a time when basic science is considered complete and all that is left is engineering and design. The natural world is still hiding its deepest mysteries.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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If Biology Can Build It, They Will Come: Ginkgo Bioworks Is Laying The Foundation For The $4 Trillion Bioeconomy – SynBioBeta

July 2nd, 2020 1:46 pm

Imagine there was a single method for making just about any product in the worldplastics,food,medicine,data storage devices, evena brain-computer interfaces. Now imagine that this method was faster, cheaper, and more sustainable than conventional manufacturing. Sounds like science fiction, right?

Its not science fiction: itssynthetic biology, a field that uses biology as a manufacturing platform. Using the latest gene-editing techniques, synthetic biology can program yeast and bacteria into tiny cellular factories capable of making an endless range of products. Its also the driving force behindthe $4 trillion bioeconomy, with great promise for building a more sustainable and abundant world.

Compared to sectors like pharmaceuticals and industrial chemicals, synthetic biology is relatively young. About 150 companies on Crunchbase describe themselves using the term synthetic biology, although SynBioBeta tracks more than 700 companies in the field. These early adopters either manufacture their own products with synthetic biology or provide synbio tools and technologies to help other companies transform the way they make things.

Early innovators in synthetic biology have had to get creative to grow not just their own businesses, but the industry as a wholeand perhaps few companies have contributed more to the industrys growth than Ginkgo Bioworks.

Ginkgo Bioworks is in a class of companies like Genomatica,Arzeda,Conagen,Zymergen, andAmyrisAMRSthat provides biotech infrastructure and servicesthe back-end of the synthetic biology industry. Rather than produce final products itself, Ginkgo designs and engineers microbes for a wide range of customer needs, from cannabinoid-producing bacteria to yeast that ferment next-generation food proteins.

Inside of Ginkgo Bioworks.

While Ginkgo believes that its microbes could one day produce virtually any physical good, most of Ginkgos would-be customers have relied for decades on traditional petrochemical or agricultural means of production. But Ginkgo isnt waiting for the slow, gradual adoption of synthetic biology by old-world players. Instead, its bringing its biology-based approach to the market by creating its own demand.

Already,Ginkgo has announced three spin-outs and strategic investments:

In February 2019 GinkgolaunchedMotif Foodworks with a $90 million Series A, the largest in food tech history. This spin-out is using microbes to provide next-generation alternative proteins and other ingredients to food companies, showing the holistic view Ginkgo takes in the synthetic biology market. Ginkgo spun out Motif to develop and manufacture animal-free food ingredients, betting that plant-based meats and alternative dairy products would grow into a lucrative market. As part of this spin-out, a servicing agreement positioned Ginkgo as the provider of the microbes that Motif would use to manufacture its products.

Depending on the project, a subsidiary like Motif might have access to Ginkgos platform and technology at no cost. Alternatively, the investment may have dollars specifically earmarked for Ginkgos services, resulting in an immediate, new revenue-paying customer. Regardless of the initial financial arrangement, Ginkgo successfully created both a promising investment and a reliable future customer in one ambitious move.

Joyn Bio is a joint ventureannouncedin March 2018 and funded to the tune of $100 million by agricultural giantBayer, Ginkgo, and Viking Global Investors. The Joyn Bio venture carries technological benefits as well, with 100,000 of Bayers proprietary microbial strains being shared with Gingko. These strains can now be incorporated into Ginkgos internal metagenomics database. Even without explicit IP transfer, Ginkgo gets to flex its technological and commercial muscles in the context of a new industry.

In the pharmaceutical industry, Ginkgo has invested $80 million in its partner Synlogic, which will use Ginkgos cell programming platform to accelerate Synlogics pipeline of living medicines. Both companies believe that the ability to program living cells to sense and respond to treat complex diseases has great potential, possibly transforming the next generation of pharmaceuticals.

We have been working with Ginkgo for over two years now, said Aoife Brennan, Synlogic CEO. We initially started with a pilot project that went so well, we expanded our collaboration.

Brennan says Synlogic has really benefited as a company from working with Ginkgo. Having access to Ginkgos expertise and foundry services has allowed us to initiate more projects and to make sure that we are moving the best synthetic biotics into further development.

Brennan says that Ginkgo is not just a good collaborator, it also shares her companys values. Both of our companies share a passion for synthetic biology and making a positive impact on the world.

As Ginkgo seeks to attract customers in new markets, spin-outs and investments like Motif, Joyn Bio, and Synlogic demonstrate to other big players how synthetic biology is going to disrupt industries like food, agriculture, and pharmaand how synthetic biology can be used to transform their own businesses.

With this business model successfully piloted, Ginkgo has begun building a pipeline of promising biotech start-ups poised to be users of its microbial design platform. Partnering with start-up incubatorsY CombinatorandPetri, Ginkgo offers select start-ups access to its services in exchange for equity. The start-ups benefit from access to a technology stack that can save them large amounts of capital and time that would otherwise be sunk into building their own microbial design infrastructure.

Ginkgo Bioworks was the first life sciences company YC funded, back in 2014, Y Combinator partner Jared Friedman told me. We believed early on that what they were building would help power the next generation of synbio startups, and its been impressive to see them execute on that mission.

Friedman says that Ginkgo is making it cheaper and easier for new companies to get started by providing them with a platform that makes engineering biology easier.

We have a shared vision for the future, one in which bio startups are as easy to start as software startups, where founders dont have to spend years and millions of dollars booting up a genetic engineering lab, said Friedman. Were proud to be part of Ginkgos continuing work to make this the standard.

Further enhancing this early pipeline of start-ups which rely on Ginkgos platform, the company recentlyannouncedthe creation of a $350 million Ferment Fund. The Ferment Fund will spin out additional companies into promising markets identified by the Ginkgo team. Not only do these investments provide Ginkgo with a stake in promising biotech firms, but they also enable Ginkgo to support the growth of a synbio ecosystem reliant on its platform.

In a demonstration of the flexibility of the companys technology platform, as well as its commitment to help in the fight against the coronavirus, Ginkgo recently took several actions to help scale the research communitys response to the pandemic.

Ginkgo announcedConcentric, a program to offer COVID-19 testing at scale to support schools and businesses in their reopening strategies. Concentric can provide end-to-end, on-site testing services for organizations that seek to make testing available to their communities.

Testing is essential for understanding and stopping the spread of the virus, Ginkgo said in anop/ed. By repurposing its next-generation sequencing capacity to rapidly scale testing, Ginkgo hopes to turn the tide.

In March, Ginkgopledged$25 million of its research and development resources to help researchers battling the coronavirus. Ginkgo has used its DNA synthesis capabilities to make the viruss sequences freely available for use in R&D for diagnostics, therapeutics and vaccines. Ginkgo also is a part of aBerkeley Lightsconsortium for antibody discovery and testing, helping to scale up infrastructure for antibody lead optimization.

As synthetic biology start-ups grow, they will continue to lean on Ginkgos platform for microbial design, since developing in-house capabilities will appear increasingly redundant with each successful Ginkgo collaboration. In this way, Ginkgo will have created a robust ecosystem of companies modeled after its own Motif Foodworks, full of start-ups that excel at developing and biomanufacturing final products while they outsource their microbial design to the Ginkgo Bioworks mothership.

Follow me on Twitter at@johncumbersand@synbiobeta. Subscribe to my weekly newsletters onsynthetic biology. Thank you toMatthew Kirshnerfor additional research and reporting in this article. Im the founder ofSynBioBeta, and some of the companies that I write aboutincluding Ginkgo Bioworksare sponsors of theSynBioBeta conferenceandweekly digestheres the full list of SynBioBeta sponsors.

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If Biology Can Build It, They Will Come: Ginkgo Bioworks Is Laying The Foundation For The $4 Trillion Bioeconomy - SynBioBeta

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Panjab University commences UG/ PG admissions: Know how to apply – The Indian Express

July 2nd, 2020 1:46 pm

By: Education Desk | New Delhi | Updated: July 2, 2020 2:25:48 pm Panjab University admissions 2020: Apply at admissions.puchd.ac.in till August 8

Panjab University admissions 2020: The Panjab University (PU), Chandigarh has invited applications for admission to various UG/ PG courses for the academic session 2020-21. The interested candidates should apply online by August 8, 2020. The online window to apply for various varsity courses will be operational from July 8.

The weblink for filling of online admission for undergraduate/ certificate courses is ugadmissions.puchd.ac.in and for postgraduate/ diploma/ advance diploma/ postgraduate diploma courses is onlineadmissions.puchd.ac.in, read the varsity release.

READ | Heres what to expect from UGCs new guidelines

The candidates will have to appear in the entrance exam to secure a seat in their desired courses. The dates of the entrance exam will be announced later.

Eligibility: The candidates with a minimum of 50 per cent marks in the Bachelors programme can apply for the entrance examination. For category-wise minimum marks requirement, please check the official notification.

Age limit: There is no prescribed age limit for the UG, PG courses. For details, please check the official notification.

PU-CET: Check paper pattern

The dates of entrance exam will be announced soon. Candidates will have to answer 75 multiple choice-based questions within the duration of 1.5 hours. Each question will be of one mark each. For every wrong answer, 0.4 marks will be deducted.

Syllabus

MA Punjabi: Punjabi culture and literature, advanced Punjabi conversation, Punjabi dramas and plays, modern age Punjabi poets, culture and heritage, literature, fair and festivals, Punjabi language, grammar and Gurmukhi

MSc Mathematics: An MCQ-based test with 100 questions each for two hours duration will be conducted wherein candidates will be assessed on mathematical skills, mathematics education, general English language, reasoning and mental ability, and general awareness.

Read |As colleges prep to reopen, some campuses to act as isolated spaces, many to offer COVID scholarships

MSc Biochemistry: The syllabus includes essential molecules of life, proteins and enzymes, metabolism of carbohydrates, lipids, amino acids and nucleotides, cell biology, membrane Biology and Bioenergetics Human Physiology and Hormones, gene organisation, replication, DNA repair, transcription and gene expression, concepts in genetics, genetic engineering and biotechnology, and immunology

MA Hindi: Students will be asses on the basis of their knowledge of Hindi literature. Questions will be asked from Hindi language and culture heritage, literature, and modes and concepts of the language.

The admission form will be charged between Rs 300 to 600 as per courses. Meanwhile, the candidates seeking admission in the sports category shall along with admission form submit the certificate/ documents in the office of Campus Sports, PU.

The Indian Express is now on Telegram. Click here to join our channel (@indianexpress) and stay updated with the latest headlines

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Kiik: I would have liked for Kadai to continue at Health Board – ERR News

July 2nd, 2020 1:46 pm

Kiik said: "We met with Martin Kadai on Tuesday for an hour and a half and we spoke on a lot of topics. During the conversation he informed me that he had previously written a letter of resignation and was strongly considering it."

The social minister added he asked Kadai to reconsider his decision and he would have liked to see the head of the Emergency Medicine Department continue but Kadai stayed true to his decision.

Kiik expressed hope Kadai will find employment in the Estonian health care sector because he has made significant contributions to it over the last three years.

Kadai's last working day will be July 5.

Although Kadai did not directly state the reason for leaving, it is related to the recent events in the office, which also removed the head of the Health Board Merike Jrilo.

Jriloannounced her resignationon June 18 saying she was disappointed by comments made by social minister Tanel Kiik todaily newspaper Postimees(link in Estonian), referring to a lack of trust between the board and the government, as the reason for her resignation.

Answering a question on whether Kadai has another position lined up and if it could be the Ministry of Social Affairs, Kiik said: "Not to my knowledge."

Mari-Anne Hrma appointed acting director general of Health Board

Mari-Anne Hrma, head of the infectious disease monitoring and epidemic control department at the Estonian Health Board, is to become the Health Board's acting director general from Thursday.

Minister of Social Affairs Tanel Kiik said: "Mari-Anne Hrma has been participating in the work of the Health Board's crisis headquarters since the start of the coronavirus crisis, she has a good overview of the Health Board's objectives and operations and she is well informed about the entire health care system.

"Additionally, Hrma also has a strong professional background and the relevant expert knowledge of the health care field. I wish her strength in taking on this role of great responsibility during this critical time when then spread of the coronavirus has decelerated for the summer period, however, work at detecting new infections must continue and preparations need to be carried out for a possible new wave."

Hrma said: "Looking at statistics on the spread of the virus, we're currently in a more relaxed period; however, the Health Board is keeping a close eye on both domestic as well as foreign epidemiological developments.

"I deem it important that my crisis-weary colleagues be able to properly rest and recover this summer, which has also been made possible by the present situation. At the same time, we are making preparations together with the ministry and other agencies for the possibility of the coronavirus starting to spread more widely now that many states are relaxing their restrictions."

Hrma holds a master's degree in genetic engineering from the University of Tartu and is currently pursuing a doctorate in biomedicine at the University of Helsinki.

Hrma, who began work in her current position at the Health board in January 2020, is a member of the European Academy of Allergy and Clinical Immunology, Finnish Diabetes Research Foundation, editor for the journal Clinical and Translational Allergy and member of the European Foundation for the Study of Diabetes.

The new director general of the Health Board will be appointed by the Government Office's civil service committee for selection of top managers. Harma has been named acting director general of the Health Board until a new director general is appointed to office.

--

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Acharangenetics: Behavior Psychology As Gene Regulation Tool – Analysis – Eurasia Review

July 2nd, 2020 1:46 pm

Behaviour is satellite responses to its environment generated by our social brain the system which we consider as mind. Mind endeavour over persuasion on which behaviour develops. Our characters are responses of some hormones produce in the cell of different gland. The shift in concentration of hormones leads to change in character.

This article reviews various effects of hormones on our physiological status and hence behavioural responses. All the body hormones produced by body cell are actually controlled and managed by the genes present in the cell. As the brain (hypothalamus) sense any character or any situation it sends the response to various hormone glands and the glands synthesis the protein as per the command of active gene.

Depending upon the circumstances behavioural response shifts vary wisely. As the behaviour is controlled by the hormones, the genes which are modulating hormones synthesis must be switching off and on as per response from brain. Specific hormone for the specific task of behaviour is produced under the command of brain. We have tried to establish a relationship between behaviour and genes so that a new study should carry out in the motive to control the gene activity by the mode of behaviour psychology. The word Acharangenetics can be used to express the relation of behaviour psychology and genes. The wordAcharangeneticsis a compound word, form by combination of two words Acharan Hindi origin word meaning behaviour and the second word is genetics the study of heredity.

The strength of any construction is understood by its pillars which are multidisciplinary in nature. To hold its existence one has to focus on its sub fundamental phenomenon, that is, behaviour. According to psychology, behaviour comprises of satellite responses to its environment generated by our social brain (Frith, C. D., 2007) the system which we consider as mind. The conscious exercise of faculty and thought are considered very important for development of mind. Mind endeavour over persuasion on which behaviour develops. Psychological practice is very commonly performed by psychologist in order to provide counselling to a person living life with some non-productive state of mind (Strong et al., 1992).

Hence, counselling can help a person to generate positive psychology, and stabilize the social life of a person with any social psychological disturbance (Harris et al., 2007). Our characters are responses of some hormones produce in the cell of different gland. The shift in concentration of hormones leads to change in character. This article reviews various effects of hormones on our physiological status and hence behavioural responses. Body hormones produced by body cell are actually controlled and managed by the genes present in the cell. As the brain (hypothalamus) sense any character or any situation it sends the response to various hormone glands (Knobil, et al., 1980; Schally, et al., 1973) and the glands synthesis the protein as per the command of active gene.

Depending upon the circumstances behavioural response shifts vary wisely. As the behaviour is controlled by the hormones, the genes which are modulating hormones synthesis must be switching off and on as per response from brain. Specific hormone for the specific task of behaviour is producd as per program under the command of brain. We have tried to establish a relationship between behaviour and genes so that a new study should carry out in the motive to control the gene activity by the mode of behaviour psychology.

Counselling psychology is very much practice in the field of academic, in the field of sports for motivating sportsman and for helping the one who is trying to come back after injury (Webster et al., 2008) or in the area of medical for strengthening the depress state of the patients suffering from chronic diseases like cancer (Watson et al.,1988; Sheard, T., & Maguire, P., 1999), diabetes (Snoek et al., 2002) or in any chronic diseases (Karademas et al., 2009) that has harassed the health as well as the mental stability of patients. Moreover, it is widely used in people who are handling life defeat mentality (Silbert et al., 1991). They are found to be very much effective in uplifting the level of psyche.

In psychology, human nature and motivation have been discussed very extensively. Freud believed that behind every human activity there is the instinctual drive that works as a motivating factor that bring upon types of human behaviour. Psychology is a science of behaviour that is observable. It also means an objective science that depends on the experimental and observable data. All human action and behaviour are the outcome of the physiological and neurological reaction in the human body. This fact also reveals that human behaviours are nothing more than the way man responses to stimuli that come from the environment.

Behaviourists accept determinism in their version of psychology. They deem that every human response can be predicted in relation to the type of stimulus that triggers mans responses. Some of our motives to act are biological, while others have personal and social origins. We are motivated to seek food, water, and sex, but our behaviour is also influenced by social approval, acceptance, the need to achieve, and the motivation to take or to avoid risks, to name a few (Morsella, Bargh, & Gollwitzer, 2009).

Furthermore, during motivation our body gene regulation work on activation of genes that is good in handling stress. And there are some genes that are responsible for the production of dopamine a motivation molecule, that provides the drive and focus you need to accomplish your tasks in the most productive way. This hormone is primarily involved with the attention span, focus and motivation. It is a neurohormone that is released by the hypothalamus. Lack of dopamine in the body is associated with symptoms like fatigue, lack of focus, difficulty in concentrating, forgetfulness, insomnia and lack of motivation.

When dopamine isnt regulated properly, it can contribute to a dysfunctional pursuit of good feelings, such as occurs in addictions, or lead to a hyperactive state like Attention Deficit/Hyperactivity Disorder (ADHD). These conditions are generally associated with an increased risk of early death, rather than longevity, but the latest study suggests that risk genes for certain problems in some environments may be beneficial in other situations.

In humans, dopamine neurotransmission is influenced by functional polymorphisms in the dopamine transporter (DAT-1) and catechol-Omethyl transferase (COMT) genes. The COMT and DAT-1 genes was found in the ventral striatum and lateral prefrontal cortex during reward anticipation and in thelateral prefrontal and orbitofrontal cortices as well as in the mid-brain at the time of reward delivery, with carriers of the DAT-1-9 repeat allele and COMT met/met allele exhibiting the highest activation, presumably reflecting functional change consequent to higher synaptic dopamine availability.

The origin of motivation can be felt as either internal as push motivation or external as pull motivation. Push motivation is depicted in terms of biological variables arising in a persons nervous system and mind psychological variables that represent attributes of a persons mind, such as psychological needs. A person has the capability to channelize its motivation and stress hormones concentration by the mode of imagination. And if a person thought is responsible for its hormone concentration, then the person thought or imagination may affect an individual gene regulation. And this gene regulation is a background of push motivation.

Pull motivation is understood in terms of environmental variables that describe external sources of motivation, like incentives or goals. Our internal sources of motivation interact with external sources to direct behaviour (Deckers, 2014). Moreover, it may happen that this external effort implants an idea in a person which allows creating a thought process rising to an imagination.

Furthermore, this imagination leads to affect the body serum metabolite concentration and signalling metabolite modulates the process of gene regulation and gene expression. Hence, it will lead to regulation to the activity of stress handling and risk handling genes (Yashin, et al., 2012). And this leads to the production of hormones such as dopamine, oxytocinetc that are responsible to manage the level of external motivation or push motivation. This system can be observed in the field of extensive sports like boxing and rugby, where coach try to motivate the energy and skills of the player by mentoring with either using sound modulation or by some moral thought related to winning or losing.

Our evolutionary history also explains aspects of motivated behaviour, and our individual personal histories shed light on how our lifelong experiences shape our motives and determine the utility of goals and incentives.

Physiological needs like hunger, thirst, sex or some desire on the basis needs are also the biological beginnings that eventually manifest themselves as a psychological drive in a persons subjective awareness. These biological events become psychological motives. It is important to distinguish the physiological need from the psychological drive it creates because only the later has motivational properties.

The drive theory of motivation tells us that physiological needs originate in our bodies. As our physiological system attempts to maintain health, it registers in our brain a psychological drive to satisfy a physiological craving and motivates us to bring the system from deficiency toward homeostasis (Reeve, 2018). Likewise, the person who motivates themselves for the personal fitness must be channelizing their serum hormones effect. This desire might be helping them to initiate a program of self-caring; a necessity in order to keep up with personal health. As people are not under control for good diet or healthy life style; personal motivation is necessary. The biological need turns into a psychological motive when the drive to satisfy it interferes with our normal functioning by increasing tension until the need is satisfied.

Behavioural feature in relation to social interaction has performed wonders in the field of medical science. Some aspects are visible through the lenses of science but some are the trades of invisible energy. Placebo effect is among that invisible behavioural energy which has stuns the eyes of many thinkers. As per the Stimulus substitution models posit that placebo responses are due to pairings of conditional and unconditional stimuli (Montgomery et al., 1997). This Condition is either created by people or may be a natural place. The placebo effect has a very vital consequence on the synthesis of metabolites in body and in functioning of hormonal glands. Placebo effect gives rise in endorphin release (Levine et al., 1978) and drop down the symptoms of anxiety (Sternbach et al., 1968.), classical conditioning (Wickramasekera et al., 1980), and response expectancy (Kirsch, et al., 1985; Kirsch et al., 1990.).

However, Montgomery and Kirsch (1996) described data that are hard to reconcile with the hypothesis that placebo responses are mediated by such global mechanisms as anxiety reduction or the release of endogenous opioids. It has been found that it can be used as a local anaesthetic.

Genetics states that, what we express as a character, whether its behaviour or phenotype it is just a pre-programmed stimulus of genes on its switching circumstances. And the circumstances could be behavioural or environmental. The change may arise sooner or later, depends on the degree of gene regulation.

On the other hand, the arising of any action or the way someone conduct them self in response to others action is judge during psychological practice. It has been observed that the change in mood, action and development of thought triggers the secretion of different metabolite, by different gland present in different parts of brain and body. The effect of any action could be seen all over the body, such as; at the time of anger the whole body share the heat arise from anger; at the stage of happiness we can feel comfort and energetic and at the stage of meditation we can feel peace. These kicks off of anger can take place by others behavioural activity but its onset initiates the production of adrenaline and noradrenaline cortisol, which anger are causing hormones. Similarly, the state of happiness is the result of production of endorphins, dopamine and serotonin. Likewise, the action of meditation kicks off the production of all good hormones required by the body to be at peace.

The effect of these hormones on whole body can only be seen if these hormones are well distributed in the body cell. Whenever any hormone enters into cell it creates a signalling response which moves from cell cytoplasm to the nucleus. And nucleus is the place where the key genetic material which codes for the behaviour of cell the structural unit of organism.

Psychology and metabolism are mutually related to each other. Any change in psych will trigger the synthesis of different hormones or metabolite or its responsible for the alteration in concentration of metabolite or hormones. And in normal condition of outer environment, social environment and diet intake, the physiological status of a person is found to be normal. Hence, the metabolite concentration is also balanced. As soon as there is any change in the environment (social/environmental) of a person, metabolite and hormonal response changes. Hence there are vital changes in person behaviour or in its health status. There is certain situation where organism has to behave against their natural character. This situation is either created by the social environment or unpredictably. Table 1 listed some of the real life situation and various responses of body metabolism

Moreover, there are situation which are either created or present naturally and are responsible for generating some rare characters in organism. As in a situation for survival some people develop very high spirit to stay alive and start working against their nature. They are found to handle stress condition with an attitude of solving it and bring out anything good as per the things available. This can be the situation of specific activation of stress handling genes by the mode of gene regulation (Yashin, et al., 2012). This regulation tends to modulate behaviour in an organism as presented in Table 2. Hence, such people are found to be having great surviving skills and a behaviour of handling tough situation.

The character whichis in phenotype form or specific social behaviour is actually a command program of the genes present in our DNA. The happening of any behaviour and expression is basically the activity of genes. Hence, learning, expression or behaving could be on and off of genes activity. This on and off of genes is understand by the terminology of gene regulationLikewise, the metabolite or hormones are actually functional protein which produces bytaking the referencefrom the coded information, by various genes in DNA of an organism. Furthermore, the behaviour of person is more likely influenced by the metabolite and hormones. Hencehuman behaviour is more likely to be as concentration of different biochemical or its just based on switching on or switching off of different genes responsible for different character which are control by production of functional protein. Hence, whenever there is activation of any gene there is activation of a specific function which contributes in any biochemical reaction throughout the body. There arenumerous biochemical reactions going on in the bodyeachactually channelize by the metabolic protein produce by the activation of genes of an organism. Apparently, the origin of basic behaviour characteris trigger by genes e.g.in infant we can observe some facial expression and actionInfants are not taught about behaviour, some of them are basically inherited by birthwhich are trigger by genes.

Moreover,if any human psychological disorder generated either by environmental or social stress are responsible for the alteration of functional protein such as hormones and metabolites. Functional protein is only produce by the activation of genes. In a nutshell genes are responsible for behaviour psychology butbehaviour psychology also holds the capacity to influence the activity of genes. Therefore, behaviour psychology at its best possible organised way may have the efficiency to govern and channelizes the activity of genes. Hence, after recognising the complete relation between psychology and genes by the connection of metabolism we can elaborate new area of study either in the field of genetic engineering or in the field of behaviour psychology.Acharangenetics(Acharan + genetics) word can be used to express the relation of behaviour psychology and genes. The wordAcharangeneticsis a compound word, form by combination of two words Acharan a Hindi origin word meaning behaviour and the second word is genetics which is the study of heredity.

Research Questions: The research questions are:

> Can we effect gene regulation by the mode of behaviour psychology?

> Can we use behaviour psychology as a genetic regulation tool?

> As genes activation affect the behaviour and create a person personality characters, can it happen that moulding someones character results in gene regulation?

Answers to the Question

The behaviour of a person is the expression of genes. The change in behaviour by the action of word may generate such hormones which leads to the expression of different genes in the individual which codes for such protein that either alter or generate new character in an individual. Hence, the transformation of human behaviour from a child to a mature person could be response of expression of genes by certain behavioural activities. A talk between two people regarding certain mutual adjustment in behaviour could be another example of gene expression of desired characters by using concept of mutual understanding of requirements. Hence, psychology can be used as a tool for expression of specific genetic traits. If social interaction and genes both affect metabolism, then they might be interacting each other. Metabolic pathway is a connective link in many biological processes therefore; it may happen that there might be a relation between genetics and behavioural psychology. If behaviour psychology can affect genes activity, then we can use it as a tool for expression of specific genetic traits. Any effect to a person during social interaction create certain level of change in its hormones or functional protein concentration lifting the mood or results in stress conditions.

*About the authors: Rajan Keshri, Harpreet Kaur and Dr Gursharan Singh Kainth, Guru Arjan Dev Institute of Development Studies

REFERENCES

Table 1: Hormone Impact on Behaviour and Body at Different Stress Situation.

Table 2: Some Examples of Hormones and Their Effects on Human Body and Behaviour.

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Image of the Month: Locating molecular players in Batten disease – Baylor College of Medicine News

July 2nd, 2020 1:45 pm

Mutations in either protein CLN6 or CLN8 result in two forms of Batten disease with remarkably similar clinical features. It turns out, as recently shown by the laboratory of Dr. Marco Sardiello, that both proteins work together to equip lysosomes, the waste-disposal hubs of the cell, of the much needed enzymes that process cellular waste.

Batten disease is a family of 13 rare, genetically distinct conditions. Collectively, they are the most prevalent cause of neurodegenerative disease in children, affecting 1 in 12,500 live births in the U.S. One of the Batten disease genes is CLN6. How mutations in this gene lead to the disease has been a mystery, but a study led by researchers at Baylor College of Medicine and published in the Journal of Clinical Investigation reveals how defective CLN6 can result in Batten disease.

People with Batten disease have problems with their cells ability to clear cellular waste, which then accumulates to toxic levels, said first author Dr. Lakshya Bajaj, who was working on this project while a doctorate student in the Sardiello lab at Baylor. Bajaj is currently a post-doctoral associate at Harvard Medical School.

In cells, lysosomes process cellular waste. They are sacs containing enzymes, a type of proteins that break down waste products into its constituent components that the cell can recycle or discard. In Batten disease caused by mutations in CLN6, the lysosomes do not process waste effectively for unknown reasons. This results in waste accumulation. Batten disease is a type of lysosomal storage disorder. Although all types of cells can be affected by defects in lysosomal waste management, brain cells, neurons, are particularly susceptible.

Waste accumulation in neurons perturbs many cellular processes and eventually results in cell death. This leads to the progressive degeneration of motor, physical and intellectual abilities observed in Batten disease patients, Bajaj said.

The connection of CLN6 with Batten disease was a bit of a mystery. This protein is not found in lysosomes, but in the endoplasmic reticulum, a structure inside cells where proteins, including lysosomal enzymes, are made. The endoplasmic reticulum is separate from the lysosomes. So, how do defects in a protein located outside of the lysosomes interfere with lysosomal function?

The Sardiello lab had previously solved a similar mystery involving CLN8, another protein located in the endoplasmic reticulum and whose mutations also cause a type of Batten disease.

We showed that CNL8 assists on the exit of lysosomal enzymes from the endoplasmic reticulum en route to the lysosomes. When CLN8 is defective, the transport of enzymes from their place of synthesis to the final destination is deficient and the lysosomes end up having fewer enzymes to work with, said Sardiello, associate professor of molecular and human genetics at Baylor and corresponding author of this work.

The clinical manifestations of Batten disease caused by CLN8 mutations and those of Batten disease due to defective CLN6 are remarkably similar. This and other evidence led the researchers to suspect that CLN6 and CLN8 might be working together.

Their investigations revealed that CLN6 and CLN8 do interact with each other forming a molecular complex that collects lysosomal enzymes at the endoplasmic reticulum and mediates their trafficking towards the lysosomes.

We propose that CLN8 and CLN6 together herd the enzymes into a hub, a sort of bus stop. Then, CLN8 escorts the enzymes on the bus en route to the lysosomes, while CLN6 remains at the bus stop. CLN8 returns to the bus stop after delivering the enzymes, and they repeat the process, Bajaj said. When CLN6 is defective, the enzymes are not effectively herded into the bus stop and fewer are transported to the lysosomes.

The researchers are interested in finding whether other factors are involved in transporting enzymes to the lysosomes. For instance, whether there are other bus conductors or herders of lysosomal enzymes involved that, if defective, may also contribute to Batten disease.

Other contributors to this work include Jaiprakash Sharma, Alberto di Ronza, Pengcheng Zhang, Aiden Eblimit, Rituraj Pal, Dany Roman, John R. Collette, Clarissa Booth, Kevin T. Chang, Richard N. Sifers, Sung Y. Jung, Jill M. Weimer, Rui Chen and Randy W. Schekman. The authors are affiliated with one or more of the following institutions: Baylor College of Medicine; Texas Childrens Hospital; University of California, Berkeley; Sanford Research, Sioux Falls, South Dakota; and Sanford School of Medicine at the University of South Dakota.

This work was supported by NIH grants NS079618 and GM127492 and grants from the Gwenyth Gray Foundation, Beyond Batten Disease Foundation and NCL-Stiftung. This project was supported in part by IDDRC grant number 1U54 HD083092 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the Integrated Microscopy Core and the Proteomics Core at Baylor College of Medicine with funding from NIH (DK56338, and CA125123), CPRIT (RP150578, RP170719), the Dan L Duncan Comprehensive Cancer Center and the John S. Dunn Gulf Coast Consortium for Chemical Genomics.

By Ana Mara Rodrguez, Ph.D.

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Rapid deployment of smartphone-based augmented reality tools for field and online education in structural biology. – Physician’s Weekly

July 2nd, 2020 1:45 pm

Structural biology education commonly employs molecular visualization software, such as PyMol, RasMol, and VMD, to allow students to appreciate structure-function relationships in biomolecules. In on-ground, classroom-based education, these programs are commonly used on University-owned devices with software preinstalled. Remote education typically involves the use of student-owned devices, which complicates the use of such software, owing to the fact that (a) student devices have differing configurations (e.g., Windows vs MacOS) and processing power, and (b) not all student devices are suitable for use with such software. Smartphones are near-ubiquitous devices, with smartphone ownership exceeding personal computer ownership, according to a recent survey. Here, we show the use of a smartphone-based augmented reality app, Augment, in a structural biology classroom exercise, which students installed independently without IT support. Post-lab attitudinal survey results indicate positive student experiences with this app. Based on our experiences, we suggest that smartphone-based molecular visualization software, such as that used in this exercise, is a powerful educational tool that is particularly well-suited for use in remote education. 2020 International Union of Biochemistry and Molecular Biology.

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Eleven Faculty and Staff Proposals Receive Pitt Seed Funding – UPJ Athletics

July 2nd, 2020 1:45 pm

At the School of Health and Rehabilitation Sciences Wellness Pavilion at the Universitys Community Engagement Center in Homewood, members and neighborhood residents will learn to take control of their health.

A campuswide collaboration at the University of Pittsburgh at Johnstown aims to enhance awareness and engagement related to diversity and inclusion, create safe spaces and foster a supportive environment that extends to neighboring communities.

The School of Laws Immigration Law Clinic will establish an asylum clinic to provide forensic evaluations for asylum seekers, train health care providers to perform them and educate medical students about the process of asylum.

These are just a few of the 11 projects named 2020 Pitt Seed Grant recipients, which represent a wide range of research, initiatives, individuals and organizations within the University and the six goals within The Plan for Pitt.

Our call for proposals received a great responseand I congratulate this years grantees. Many of the projects funded this year reflect our continued commitment to social justice and active outreach to communities in need, said Ann E. Cudd, provost and senior vice chancellor. We have committed support to projects that reflect our deep interest in further exploring ways to evaluate teaching effectiveness, as well as to probe innovations in both the advising and remote learning spaces. All of this is important workand I am very excited to support these extremely interesting initiatives.

The Pitt Seed Project Initiative received more than 60 letters of intent and 45 total applications, including 30 from faculty and 15 from staff. Sixty-eight volunteers from various units across Pitt participated in reviewing grant applications. Their recommendations were reviewed and endorsed by Provost Cudd before being presented to and approved by Chancellor Patrick Gallagher.

The 11 proposal summaries and their designated points of contactare:

Brandon Barber, BioE design, innovation and outreach coordinatorSwanson School of Engineering

The purpose of the XProjects Applied Research XPloration (XARX) is to further develop the Pitt XProject programs internal research collaborations and explore new applications of ongoing research, while simultaneously providing students with cocurricular design/engineering experiences that go beyond the classroom. The diverse multidisciplinary teams employ a rigorous process and a proven suite of tools to navigate fast-paced project work, all while gaining practice with project management, prototyping and negotiating stakeholder-client relationships. This innovative approach to design education also creates an environment where students can gain the experience they need to more confidently approach and define complex problems.

April Belback, director for undergraduate advising and mentoringOffice of the Provost

The University ofPittsburghAdvisingCertification andTraining Program (Pitt-ACT)is a large-scale collaboration between the Office of the Provost Undergraduate Studies Academic Innovation Team, the Center for Teaching and Learning and undergraduate academic and advising units across the University. Designed for faculty and staff at Pitt who work with students in an advising and mentoring capacity, the project creates a suite of online onboarding and training materials to help standardize the practice of advising across Pitt.

Kevin Binning, assistant professorDepartment of Psychology in the Kenneth P. Dietrich School of Arts and Sciences

The proposed project will leverage existing institutional datasets to develop, validate and standardize new methods for assessing teaching effectiveness. In particular, the project will quantify the impact that particular instructors have on student outcomes, including subsequent retention, major choice and academic performance. This will be used to help Pitt improve by helping instructors understand the effectiveness of their teaching practices while also providing standardized benchmarks to evaluate the effectiveness of educational interventions.

Josh Cannon, scholar mentorUniversity Honors College

This project seeks to raise the number of National Science Foundation Graduate Research Fellowship Project (NSF GRFP) winners among Pitt's graduate and undergraduate (seniors) populations. The project collaborators will host a series of workshops that provide strategies and guidance on application preparation, as well as bring in faculty and advanced graduate students to provide their own insights and expertise to applicants. Scholars in the appropriate fields will provide draft review services for each application. The seed grant will support this project for the 2020-2021 and 2021-2022 academic years.

Vaughn Cooper, professorDepartment of Microbiology and Molecular Genetics in the School of Medicine

The EvolvingSTEM program addresses the critical need for engaging, equitable learning practices that support student success and promote a well-educated, diverse STEM workforce. Pitt Seed funding will support efforts to provide an after-school program to underserved students from the Pittsburgh Public School system at the Community Engagement Center in Homewoods modern laboratory space. Students will design, conduct and analyze their own bacterial evolution experiment under the guidance of Pitt undergraduate mentors. Student projects will utilize cutting-edge laboratory and computational techniques, including bioinformatic analyses of genomic DNA sequencing data.

Tuangtip Klinbubpa, associate professorDepartment of English at the University of Pittsburgh at Johnstown

This project is a campuswide, collaborative, multidisciplinary, personalized effort that will take place at Pitt-Johnstown and extend to the neighboring communities. The project aimsto enhance awareness and engagement related to diversity and inclusion,sustainably engage Pitt-Johnstown and the neighboring communities in promoting diversity and inclusionand create safe spaces and a supportive environment for all.

Lingfeng Liu, lab instructorDepartment of Chemistry in the Dietrich School of Arts and Sciences

We will bring ECoach, a personalized coaching tool developed at the University of Michigan, to Pitt. ECoach allows professors to personalize feedback to students to support success in large enrollment STEM courses.

Channing Moreland, Wellness Pavilion directorSchool of Health and Rehabilitation Sciences

The School of Health and Rehabilitation Sciences Wellness Pavilion is a student-led space inside The W.E.L.L (Wellness, Education, Living & Learning) at Pitts Community Engagement Center in Homewood. This community-engaged and interdisciplinary space was designed for Homewood and surrounding communities residents to feel heard and empowered to improve, maintain and take control of their health and wellness. To do so, the space provides free evidence-based health and wellness services and programs for residents across the lifespan. Moreover, the pavilion is committed to fostering healthy relationships between students, faculty, staff and community members via interprofessional collaborations and person-centered approaches to care. The Wellness Pavilion intends to maintain and initiate mutually beneficial partnerships within Homewood and surrounding communities to fortify University-specific strategic priorities. Community-based learning will occur at the pavilion, which will advance teaching practices, appeal to diverse applicants seeking admission and/or employment at the University and positively impact the student experience.

Joseph Samosky, assistant professorDepartment of Bioengineering in the Swanson School of Engineering

Classroom to Communityis forstudentswho want to creatively design andinvent solutions for real-worldproblems and needs.Space, resources and mentorship will be provided for students to learn powerfulhuman-centereddesign tools and methods, build bridges with community partners and create diverse teams fromdifferent backgrounds, majors and schools. Together we will co-createan engaging, multidisciplinary experience for students to explore, envision, share and learn from faculty partners and each other as they translate their ideas into something new in the world that benefits others.The projects ultimate goals are to foster a culture of innovation, agency and service; empower students to discover their creative potential; and become agents of positive change.

Sheila Velez Martinez, Jack and Lovell Olender Professor of Refugee, Asylum, and Immigration Lawand director of clinical programsSchool of Law

The Immigration Law Clinic and students and faculty at the School of Medicine are engaged in an effort to establish an asylum clinic that would provide forensic evaluations for asylum seekers. By documenting the physical and psychological sequelae of human rights abuses and submitting a medical-legal affidavit to court, physicians and students can make a difference in whether these individuals are granted asylum or other relief from deportation. The clinic will also train health care providers to perform asylum evaluations and educate medical students about the process of asylum and the role of health care providers in asylum. Shadowing asylum evaluations not only exposes students to the unique points of view of human rights atrocity survivors, but also allows them to observe and practice trauma-informed interviewing and cross-cultural communication.

Anna Wang-Erickson, assistant professor and associate directorInstitute for Infection, Immunity, and Inflammation in Children (i4Kids), Department of Pediatrics in the School of Medicine

Speaking and networking at conferences is crucial to career advancement, and these opportunities often create a need for occasional nonroutine dependent care. This burden disproportionately affects women and people early in their careers. This project aims to create University-wide infrastructure and policies to support the career and professional network development of faculty, staff, postdoctoral fellows and graduate students through occasional nonroutine dependent care support. Additionally, it will evaluate the efficacy and impact of the new infrastructure and policies to improve efforts in building professional networks and promoting work done at Pitt at the international level.

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POINT OF CARE MOLECULAR DIAGNOSTICS MARKET EXPECTATION SURGES WITH RISING DEMAND AND CHANGING TRENDS AGILENT TECHNOLOGIES INC., ABBOTT, F. HOFFMANN-LA…

July 2nd, 2020 1:45 pm

A comprehensiveGlobal Point of Care Molecular Diagnostics Marketanalysis report serves to be an ideal solution for better understanding of the market and high business growth. It has become the requisite of this rapidly changing market place to take up such marker report that makes aware about the market conditions around. This market report comprises of an array of factors that have an influence on the market and industry which are industry insight and critical success factors (CSFs), market segmentation and value chain analysis, industry dynamics, drivers, restraints, key opportunities, technology and application outlook, country-level and regional analysis, competitive landscape, company market share analysis and key company profiles.

Market Analysis:

TheGlobal Point of Care Molecular Diagnostics Marketis estimated to rise from the value of USD 627.6 million in 2017 to an estimated value of USD 1933.2 million by 2025, registering a CAGR of 15.1% during the forecast period of 2018-2025. This growth can be attributed to the rising cases of infectious diseases, and the growing demand for approved Point of Care Molecular Diagnostic tests.

Key Market Competitors:Few of the major competitors currently working on the Point of Care Molecular Diagnostics Market are Agilent Technologies Inc., Abbott, F. Hoffmann-La Roche Ltd., Illumina Inc., Hologic Inc., QIAGEN, Myriad Genetics, Cepheid, Genomic Health, GenePOC Inc., DxNA LLC., Binx Health Inc., Spartan Bioscience Inc., Biocartis, Beckman Coulter Inc., Johnson & Johnson Services Inc., Medtronic, Siemens Healthcare GmbH, Grifols S.A., Abaxis, Bayer AG, bioMrieux SA, Bio-Rad Laboratories Inc., Danaher, OraSure Technologies Inc., BD, Sysmex Corporation, Quidel Corporation, and Meridian Bioscience Inc.

Get Sample Report + All Related Graphs & Charts @https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-point-of-care-molecular-diagnostics-market

Global Point of Care Molecular Diagnostics Market,By Product (Assays & Kits, Instruments/Analyzers, Services & Software), Application (Respiratory Diseases, Sexually Transmitted Diseases, Hospital-acquired Infection, Oncology, Hepatitis, Others), Technology (Polymerase Chain Reaction, In-Situ Hybridization, Chips and Microarrays, Mass Spectrometry, Sequencing, Isothermal Amplification, Others), End-User (Physician Offices, Hospitals, Research Institutes, Others), Geography (North America, South America, Europe, Asia-Pacific, Middle East & Africa) Industry Trends & Forecast to 2025

Competitive Analysis:

The Global Point of Care Molecular Diagnostics Market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of Point of Care Molecular Diagnostics market for global, Europe, North America, Asia Pacific, South America and Middle East & Africa.

Market Definition:Global Point of Care Molecular Diagnostics Market

Point of Care Molecular Diagnostics is diagnostic equipment which is used to determine the cause of infectious disease causing agents. These machines/equipments help determine the accurate cause of these diseases in a timely manner, which is of utmost importance when dealing with these kind of diseases and also to implement the correct course of action.

The advancements and developments in the diagnostics market is attributed to the fact that the healthcare industry is focusing on detection and diagnosis in place of pharmaceuticals and medicines, to prevent the development of the diseases. This trend has directly affected the market growth and is helping the market to grow significantly.

North America had the highest revenue share of around 40% of the market.

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Market Drivers:

Market Restraints:

Segmentation:Global Point of Care Molecular Diagnostics Market

Key Developments in the Market:Global Point of Care Molecular Diagnostics Market

Key Insights in the report:

Market Segmentation:-

To comprehend Global Point of Care Molecular Diagnostics market dynamics in the world mainly, the worldwide Point of Care Molecular Diagnostics market is analyzed across major global regions.

Actual Numbers & In-Depth Analysis, Business opportunities, Market Size Estimation Available in Full Report.

Some of the Major Highlights of TOC covers:

Chapter 1: Methodology & Scope

Definition and forecast parameters

Methodology and forecast parameters

Data Sources

Chapter 2: Executive Summary

Business trends

Regional trends

Product trends

End-use trends

Chapter 3: Industry Insights

Industry segmentation

Industry landscape

Vendor matrix

Technological and innovation landscape

For More Insights Get Detailed TOC @https://www.databridgemarketresearch.com/toc/?dbmr=global-point-of-care-molecular-diagnostics-market

Point of Care Molecular Diagnostics Market report effectively provides required features of the global market for the population and for the business looking people for mergers & acquisitions, making investments, new vendors or concerned in searching for the appreciated global market research facilities. It offers sample on the size, offer, and development rate of the market. The Point of Care Molecular Diagnostics report provides the complete structure and fundamental overview of the industry market.

Note: If you have any special requirements, please let us know and we will offer you the report as you want.

About Data Bridge Market Research:

Data Bridge Market Researchset forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market. Data Bridge endeavors to provide appropriate solutions to the complex business challenges and initiates an effortless decision-making process.

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POINT OF CARE MOLECULAR DIAGNOSTICS MARKET EXPECTATION SURGES WITH RISING DEMAND AND CHANGING TRENDS AGILENT TECHNOLOGIES INC., ABBOTT, F. HOFFMANN-LA...

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Outlook on the Array Instruments Global Industry to 2025 – Featuring Affymetrix, Agilent Technologies & Arrayit Among Others -…

July 2nd, 2020 1:45 pm

DUBLIN--(BUSINESS WIRE)--The "Array Instruments Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2020-2025" report has been added to ResearchAndMarkets.com's offering.

The global array instruments market is currently witnessing strong growth. An array instrument is used in laboratories for quantitatively and simultaneously monitoring the expression of multiple genes. It contains numerous small representative tissue samples from hundreds of different cases, which are assembled on a single histologic slide.

The high-throughput approach of the array instrument aids in locating chromosomal expressions and mutations in a genotype, as well as measuring and detecting gene expressions at the messenger RNA (mRNA) or protein level. As a result, it finds applications in molecular and cell biology, genetics, molecular pathology, and for synthesizing and sequencing nucleic acids.

The increasing prevalence of chronic diseases, in confluence with the emerging need for their early detection and diagnosis, represents one of the key factors driving the global array instruments market growth. In addition to this, governments of several countries are investing in the improvement of healthcare facilities, which in turn, is positively influencing the demand for array instruments, especially in emerging economies.

Furthermore, these instruments can be incorporated with a wide range of technologies, owing to which they find applications in different areas of research, such as life sciences and drug discovery. For instance, deoxyribonucleic acid (DNA) microarrays are used for examining changes in gene expression by fluorescent labeling of complementary DNA, whereas tissue microarrays aid in identifying new diagnostic and prognostic markers and targeting cancer in human beings. Other than this, the introduction of advanced technologies, such as microarray-based comparative genomic hybridization (array CGH), is expected to bolster the market growth in the upcoming years. Looking forward, the publisher expects the market to register a CAGR of around 7% during 2020-2025.

Companies Mentioned

Key Questions Answered in this Report:

Key Topics Covered:

1 Preface

2 Scope and Methodology

3 Executive Summary

4 Introduction

4.1 Overview

4.2 Key Industry Trends

5 Global Array Instruments Market

5.1 Market Overview

5.2 Market Performance

5.3 Market Forecast

6 Market Breakup by Application

6.1 Molecular Biology

6.1.1 Market Trends

6.1.2 Market Forecast

6.2 Cell Biology

6.2.1 Market Trends

6.2.2 Market Forecast

6.3 Genetics

6.3.1 Market Trends

6.3.2 Market Forecast

6.4 Molecular Pathology

6.4.1 Market Trends

6.4.2 Market Forecast

6.5 Others

6.5.1 Market Trends

6.5.2 Market Forecast

7 Market Breakup by Technology

7.1 DNA Microarrays

7.1.1 Market Trends

7.1.2 Market Forecast

7.2 Protein Microarrays

7.2.1 Market Trends

7.2.2 Market Forecast

7.3 Cellular Microarrays

7.3.1 Market Trends

7.3.2 Market Forecast

7.4 Tissue Microarrays

7.4.1 Market Trends

7.4.2 Market Forecast

8 Market Breakup by End-User

8.1 Research and Development Laboratories

8.1.1 Market Trends

8.1.2 Market Forecast

8.2 Clinical Diagnostic Labs

8.2.1 Market Trends

8.2.2 Market Forecast

8.3 Agriculture Research Centers

8.3.1 Market Trends

8.3.2 Market Forecast

8.4 Veterinary Laboratories

8.4.1 Market Trends

8.4.2 Market Forecast

8.5 Forensic Centers

8.5.1 Market Trends

8.5.2 Market Forecast

8.6 Others

8.6.1 Market Trends

8.6.2 Market Forecast

9 Market Breakup by Region

9.1 North America

9.2 Asia Pacific

9.3 Europe

9.4 Latin America

9.5 Middle East and Africa

10 SWOT Analysis

11 Value Chain Analysis

12 Porters Five Forces Analysis

13 Price Indicators

14 Competitive Landscape

14.1 Market Structure

14.2 Key Players

14.3 Profiles of Key Players

For more information about this report visit https://www.researchandmarkets.com/r/f83v23

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Outlook on the Array Instruments Global Industry to 2025 - Featuring Affymetrix, Agilent Technologies & Arrayit Among Others -...

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In what does Cuba’s genetic study of patients recovered from COVID-19 consist of? – OnCubaNews

July 2nd, 2020 1:45 pm

Help us keep OnCuba alive here

The appearance at the end of 2019 of a new coronavirus and its rapid spread throughout the world until it became a pandemic, has put the scientific community to work with an intensity rarely observed.

Although currently the main international research is focused on the search for the vaccine, the mass immunization as the only way to stop such a contagious virus, another question arises from a characteristic of the virus, or rather how each person responds to the contagion: Why do some die from COVID-19 and others dont get to feel the slightest symptom?

The answer may lie in genetics; thats why Cuba launched a research that takes this factor into account in the response of those who suffered from the disease and those who have already been discharged.

According to the director of the National Center for Medical Genetics, Beatriz Marcheco, the project includes clinical-epidemiological, laboratory, basically hematological, immunological, and DNA studies.

The research began its clinical stage in early June, in the provinces of Pinar del Ro, Cienfuegos and Las Tunas, as well as the municipality of La Lisa, in Havana.

The study seeks to find out the blood group and factor of each individual and to study the subpopulations of lymphocytes that participate in the immune response, using flow cytometry and Elisa assays, explained the specialist in an interview with Granma daily.

Cuba studying genetic factors of patients recovered from COVID-19

After taking the blood sample, these are taken to the laboratories of the National Center for Medical Genetics to submit them to the tests related to the study, in which the Immunoassay Center also participatesthe Immunoglobulin g test is done there to identify if the person has specific antibodies against the SARS-CoV-2 virusand the Center for Molecular Immunology.

The results could help scientists to characterize all the factors related to the incidence of the disease, its lethality and clinical and therapeutic approach in each case.

If, for example, an individual is identified as being more vulnerable to symptoms or severity, strategies to prevent such severity could be applied with early therapeutic interventions, Marcheco added.

By identifying the genetic factors related to clinical severity, we will be taking a significant step at the same time in the objective of developing personalized treatments that respond to individual genetic characteristics, strengthening the implementation of population-based prevention strategies, she explained.

The studies we are conducting also allow us to appreciate how each person is recovering individually from a disease that strongly damages the immune system. Therefore, the research project contains actions that are part of the strategy of our health system in the post-COVID-19 stage of each patient, she said.

The screening also includes the study of a first-degree relative (mother, father, son or daughter, brother or sister) who lives with the positive case and was exposed to the virus, but had no symptoms nor was positive for COVID-19.

The study of these subjects can be very useful in identifying protective factors against the virus and that is also important in terms of prevention, the scientist concluded.

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In what does Cuba's genetic study of patients recovered from COVID-19 consist of? - OnCubaNews

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Why Every Person Reacts Differently to Diets – Bicycling

July 2nd, 2020 1:45 pm

The majority of nutritional advice is general, out of necessity, and some of it does apply to everyonelike eating more vegetables and drinking enough water.

But when it comes to more specific strategieslike how much to eat in order to lose or maintain weight and what you should be eating to achieve thatit can get tricky. New research suggests the issue is complicated because individuals can have different reactions to the amount and type of food compared to others eating the same quantity and meals.

In a small study published in the journal Nature Food, researchers served 19 volunteers four different types of meals comprised of foods ranging from heavy on fruits and vegetables to those typical of a fast food dinner. The people ate these meals over four three-day inpatient periods, which means compliance was closely monitored.

After analyzing urine through molecular profiling technology, researchers found different patterns of chemical composition, suggesting unique responses to the food based on how it was being metabolized. Also, even though everyone ate the same amount of calories, some people excreted more calories through their urine than others, researchers found.

This is because of the way each persons metabolic pathways are activated, a process often called metabolic flexibility, said study coauthor Jeremy Nicholson, Ph.D., professor and pro-vice chancellor of health sciences at Murdoch University in Australia.

Most nutritional advice is general, but we know that one size does not fit all, he told Bicycling. In the future, it will be normal to have individualized diets, but these will be informed by metabolism, not genetics. Thats because through your life, your dynamic phenotype [characteristics that change over time] is influenced not just by genes but also by lifestyle, diet, exercise, gut microbes, medications, and other factors.

In the same way that long-term health risks can be pinpointed through factors like these, it may be possible to tailor healthy eating advice in the same way, using molecular technology to understand an individuals metabolic flexibilityand tweak nutrition plans based on that, Nicholson said.

[Gravel! prepares you with everything you need to know to crush it, including the best gear, how to train, and much more!]

Until the day comes when insights like those become commonplace in a way thats commercially available, it may be helpful to understand that even with healthy foods, you may have a different response than someone else eating the exact same amount and diet.

And, as Nicholson noted, there are metabolic game changers like exercise and gut health that can change how you're reacting to foods, so making healthy changes to those could switch up your metabolic flexibility in the long run.

The bottom line? Its worth noting how you react to different foods, and realizing that everyone is differentwhat works for other people might not work for you. Meeting with a sports dietitian to get a plan thats tailored to you could be a good first step toward eating in a way that benefits your body specifically.

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