StemCell Therapy

Diabetic Neuropathy Therapeutics Market has witnessed continuous growth within the past few years and is projected to grow even more throughout the forecast period (2020 2027). The analysis presents a whole assessment of the market and contains Future trends, Current Growth Factors, attentive opinions, facts, historical information, and statistically supported and trade valid market information.

The report, titled Global Diabetic Neuropathy Therapeutics Market defines and briefs readers about its products, applications, and specifications. The research lists key companies operating in the global market and also highlights the key changing trends adopted by the companies to maintain their dominance. By using SWOT analysis and Porters five force analysis tools, the strengths, weaknesses, opportunities, and threats of key companies are all mentioned in the report. All leading players in this global market are profiled with details such as product types, business overview, sales, manufacturing base, competitors, applications, and specifications.

You Can Request A Demo Version of Report Before Buying (Higher Preference For Corporate Email ID User): https://www.worldwidemarketreports.com/sample/141541

Abbott Laboratories, Hoffmann-La Roche Ltd, Eli Lilly and Company, Johnson & Johnson, GlaxoSmithKline Plc, Lupin Limited, Glenmark Pharmaceuticals Limited, Depomed Inc., Astellas Pharma Inc, Pfizer Inc of the major organizations dominating the global market.(*Note: Other Players Can be Added per Request)

1. Industry outlookThis is where youll find the current state of the Diabetic Neuropathy Therapeutics industry overall and where its headed. Relevant industry metrics like size, trends, life cycle, and projected growth included here. This report comes prepared with the data to back up your business idea. On a regional basis, the Global Diabetic Neuropathy Therapeutics market has been segmented into Asia-Pacific, North America, Europe, Latin America, and the Middle East and Africa.

2. Target marketThis target market section of study includes the following:

User persona and characteristics: It includes demographics such as age, income, and location. It lets you know what their interests and buying habits are, as well as explain the best position to meet their needs.

Market size: How big is the potential Diabetic Neuropathy Therapeutics market for your business? It brings to light the consumption in the Diabetic Neuropathy Therapeutics industry by the type and application.

3. Competitive analysisDiscover your competitors. The report lets you know what youre up against, but it also lets you spot the competitions weaknesses. Are there customers that are underserved? What can you offer that similar businesses arent offering? The competitive analysis contains the following components:

Direct competitors: What other companies are offering similar products and services? Which companies are your true competitors?

Competitor strengths and weaknesses: What is your competition good at? Where do they fall behind? Get insights to spot opportunities to excel where others are falling short.

Barriers to entry: What are the potential pitfalls of entering the Diabetic Neuropathy Therapeutics market? Whats the cost of entry? Is it prohibitively high, or easy to enter?

The window of opportunity:Does your entry into the Diabetic Neuropathy Therapeutics industry rely on time-sensitive technology? Do you need to enter early to take advantage of an emerging market?

4. ProjectionsLikewise, We offered thoughtful, not hockey-stick forecasting.

Market share:We have given the consumption behavior of users. When you know how much can your future customers spend, then only youll understand how much of the Diabetic Neuropathy Therapeutics industry you have a chance to grab, and here we came up with real stats and numbers.

Impact Analysis of COVID-19:The complete version of the Report will include the impact of the COVID-19, and anticipated change on the future outlook of the industry, by taking into account the political, economic, social, and technological parameters.

Finally, It is one report that hasnt shied away from taking a critical look at the current status and future outlook for the consumption/sales of these products, by the end users and applications. Not forgetting the market share control and growth rate of the Diabetic Neuropathy Therapeutics Industry, per application. Most noteworthy, this market analysis will help you find market blind spots.

About WMR

Worldwide Market Reports is your one-stop repository of detailed and in-depth market research reports compiled by an extensive list of publishers from across the globe. We offer reports across virtually all domains and an exhaustive list of sub-domains under the sun. The in-depth market analysis by some of the most vastly experienced analysts provide our diverse range of clients from across all industries with vital decision making insights to plan and align their market strategies in line with current market trends.

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See the original post:
Diabetic Neuropathy Therapeutics Market: Forecast With Size, Share, Analysis, Rising Demand and Opportunity Outlook: Abbott Laboratories, Hoffmann-La...

The novel, Blindness, by Portuguese Nobel Laureate Jos Saramago, is strikingly prescient about a sweeping illness. The plot revolves around a mysterious epidemic because of which people suddenly turn blind.

It starts with a person driving his car who turns blind while waiting at a traffic signal. He pleads to be taken home and a man, on the pretext of helping, takes him home but soon after runs away with his car. The contagion spreads rapidly and all those affected by the epidemic are quarantined in an asylum. The novel follows seven people, who do not have names but only descriptions: the doctor, the doctors wife, the girl with the dark glasses, etc. Lack of equitable delivery of food, inhospitable and unhygienic living conditions, police brutality and apathy of power structures lead to panic among the blind. They are on the brink of starvation. Seven characters escape the asylum and enter the city where they came from only to find that everybody in the city has become blind. Lacking any support, the country plunges into utter despair before resurrection happens quite magically.

Also read | Whos afraid of a virus wolf?

Apart from the obvious connections with the pandemic, there are other, numerous and allegorical ways in which Saramagos world resonates with contemporary India.

Consider for example, the case of blindness regarding the number of migrant workers. The governments own data sources are inconsistent and are a massive underestimate. The office of the Chief Labour Commissioner stated that there are 26 lakh migrants while various estimates, including the Economic Survey, put this number above 8 crore people. The anonymity of the workers has been reinforced as governments have not kept records of who they are and where they are working. This lack of accountability has given a free rein to the complex web of contractors and sub-contractors to exert various forms of exploitation. The migrant workers, like the characters in Blindness, have been rendered nameless in this unequal power gambit.

Then, there is the blindness about hunger and deaths. On June 30, Prime Minister Narendra Modi announced free food grains for National Food Security Act (NFSA) beneficiaries till November. While it is a welcome move, it yet again excludes those without ration cards. As per estimates of Meghana Mungikar, Jean Drze, and Reetika Khera, roughly 10 crore eligible beneficiaries continue to be excluded under the NFSA . This is because the central government is still using 2011 Census data and hence underestimates NFSA coverage. Moreover, migrants and many self-employed workers do not have ration cards. At a time when the warehouses of the Food Corporation of India have 2.5 times the buffer stock norms, not universalising rations is inexplicable.

Also read | Getting cash transfers out of a JAM

Two petitions concerning food and income support for migrants were summarily dismissed by the Supreme Court of India during lockdown. The Court finally took suo motu cognisance of the crisis after 20 senior lawyers wrote a letter to the Chief Justice of India to intervene. The Solicitor General, Tushar Mehta, representing the Union of India, has submitted that there has been no death in the Shramik trains because of lack of water and food, and all deaths took place due to earlier illnesses. On May 15, Union Minister of Railways Piyush Goyal at Bennett University said, We have gone through the entire three months without a single person starving. In reality, there have been at least 850 non-COVID deaths due to an unplanned lockdown. Indian Railway Protection Force Service data show that there have been 80 deaths in Shramik trains alone between May 9 and May 27; most of these are due to starvation and financial distress. Numerous ground reports indicated the extent of hunger. As in Stranded Workers Action Network (SWAN) reports covering more than 34,000 workers, 50% had just one day of rations left and 64% had less than 100 when they reached out during the lockdown. In such light, the combination of falsehoods and measured silence by the governing institutions and the judiciary indicate that they have been afflicted by Saramagos imaginary epidemic of blindness that refused to see the gravity of the crisis.

As rising cases of COVID-19 suggest, the lockdown did not curb the spread of the virus. It was a unilateral decision taken, apparently, to buy time to create health-care facilities. However, the governments hubris backfired. The resilience and the perseverance of the migrants exerting their fundamental right to return pushed the government to respond this time. The SWAN report says: While a part of the governments slow response is due to the lack of empathy towards workers, a part is also the result of inefficiencies resulting from unilateral decision-making. Consequently, the government has created an archive of distress and a museum of misery. The maze of obfuscating travel orders and the opacity surrounding train schedules was as if the migrants were made to play a cruel game of snakes and ladders. The lucky ones took the metaphorical ladder to the train only to find themselves hungry and fighting with fellow migrant travellers to get food. Even among them, most have had to pay for travel forms, pay bribes and face police brutality. The resemblances with the plight of those in Saramagos novel are uncanny. The unlucky ones stayed back, some evicted from their rented spaces, waiting anxiously for their illusory chance to come. As a character says in the Saramago novel, ... you have to wait, give it time, its time that rules, time is our gambling partner on the other side of the table and it holds all the cards of the deck in its hand, we have to guess the winning cards of life, our lives.

Full coverage | Lockdown displaces lakhs of migrants

Unlike Saramagos fictional world, such systemic and structural blindness has no magical cure. After continued hostility that workers were forced to endure, it is difficult to pin down the precise analytical reasons for the diverse expressions from migrants. Some have been resolute about returning immediately while some are unable to return home without earnings. Surveys cannot do full justice to understanding these amalgam of expressions and would at best create reductive categories. We definitely do not need piecemeal platitudes coming from the central government. We need many corrections such as stronger adherence to constitutional values, transparency and accountability from the government and the judiciary. And, not just those in power but also those who elect them need to collectively treat the epidemic of blindness that has eroded our moral core where we do not feel uneasy in seeing the hardships of marginalised communities.

Rajendran Narayanan teaches at Azim Premji University and has been a SWAN volunteer

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The pandemic is about eyes shut - The Hindu

A hand sanitiser is being recalled after it was found to contain potentially lethal chemicals that are highly toxic to humans and can catch fire.

Thealert was issued on July 7 by The Chartered Trading Standards Institute for Shield Hand Sanitiser Gel.

Not only is the product ineffective at killing bacteria or viruses, but contains the toxic substance methanol that can be a fire risk, the alert warns.

Made in the UK, the 100ml gel is packaged in a plastic bottle and is available with a black or white self-closing cap.

The alert states: "Consequently, it does not kill bacteria or viruses, which could then reach the user, increasing the risk of infection.

"The product does contain methanol (measured value: 3.4%), which is acutely toxic to the central nervous system and the eye.

Follow all coronavirus updates on our live blog here

"Ingestion or contact with methanol leads to blindness and death.

"Furthermore, the presence of methanol is not accompanied by the corresponding hazard pictograms and warnings.

"Users have therefore no information on the toxicity and flammability of the product, which in the presence of an ignition source, could lead to a fire."

The news of the recall comes as tens of thousands of people in "high-risk" jobs will be tested for coronavirus despite having no symptoms as part of a new government scheme.

People including taxi drivers, cleaners and shop assistants will be involved in the pilot announced by the Department of Health and Social Care today.

See the rest here:
Toxic hand sanitiser urgently recalled over fears it can cause blindness - Mirror Online

Taking in archival imagery, conservation objects, and photographs of plant activists, visual artist Liz Orton dissects the field of botany to invite us to look at nature in a more profound way.

According to botanists, todays extinction crisis is partly a problem of plant blindness. We dont see or know plants in the way we see and know animals, and they are going extinct at 500 times the natural rate, writes photographer Liz Orton.

Her ongoing work, Herbarium of Extinction, revolves around this statement, questioning in a variety of visual forms the reason for this blindness. That is, while botany originated in prehistory as herbalism with the efforts of early humans to identify and later cultivate edible, medicinal and poisonous plants, these efforts to calatogue plants led in the 18th century to the binomial system, approaching plants according to their only biological aspects.

This system remains in use to this day, with the consequence to alter our emotional proximity to plants. In a poetic way, Orton introduces the notion of attachment and memory that we are lacking for the flora by including to her series objects that used to belong to her mother a framed photograph of plants, a brush such as those used to clean nails after gardening, a dictionary open to the entry E as in extinction. Thats a personal story around lost and care, how you might use representation if you want to retrieve or recover something, she says.

Delving into the past of her subject, she was also triggered by the latin naming of plants associated to the binominal system. You could say in a way that botany was one of colonialisms agents of operation, she notes. To convey such an abstract concept, Orton worked with ancient botanical collections that have been digitised. Using available images of endangered specimens, she cleaned them, manipulated them, ultimately takes it one step further away from the plant itself. And by doing so, she also appropriates the process of digital repatriation - the return of items of cultural heritage in a digital format to the communities from which they originated to subtly point at imperialism. And what, if not imperialism, turned us to think of the world as always more accessible and available, in other words, consumable?

As an engaging counterpoint, portraits of plant activists and experts interacting with plants round off the series. Nature tends to be designated as a passive, static, backdrop across which the body works. And I was more interested in like the idea of the exchange between the body and the plant, Orton explains. I often told to the people, lets let the plant make the first move. The result is a gentle choreography of leaves and arms, branches and bodies, flowers and hands that arouse a curiosity to carefully look at nature again. With something else than our eyes.

--------------

Liz Orton is a visual artist working with photography, text and film to explore the relationship between images, knowledge and authorship. Her work engages widely with archives, both real and imagined, to explore the tensions between personal and scientific forms of knowledge.

Laurence Cornet is a writer and curator based in Paris focusing on cultural and environmental issues. She is also the editorial director of Dysturb.

--------------

This article is part of our feature series Photo Kernel, which aims to give space to the best contemporary practitioners in our community. The word Kernel means the core, centre, or essence of an object, but it also refers to image processing.

See more here:
The Alarming Phenomenon of Plant Blindness - PHmuseum

Associative freedom is often entirely absent from popular discourse about liberalism and our political debates, perhaps because liberals have come to take it entirely for granted.

Overall, the liberal ideal is a diverse, pluralistic society of autonomous people guided by reason and tolerance. The dream is harmonious coexistence. But liberalism also happens to excel at generating dissensus, and some of the major sociopolitical controversies of the past few years should be understood as conflicts not between liberalism and something else but between parties placing emphasis on different liberal freedomschiefly freedom of speech, a popular favorite which needs no introduction, and freedom of association, the under-heralded right of individuals to unite for a common purpose or in alignment with a particular set of values. Like free speech, freedom of association has been enshrined in liberal democratic jurisprudence here and across the world; liberal theorists from John Stuart Mill to John Rawls have declared it one of the essential human liberties. Yet associative freedom is often entirely absent from popular discourse about liberalism and our political debates, perhaps because liberals have come to take it entirely for granted.

For instance, while public universities in America are generally bound by the First Amendment, controversial speakers have no broad right to speak at private institutions. Those institutions do, however, have a right to decide what ideas they are and arent interested in entertaining and what people they believe will or will not be useful to their communities of scholarsa right that limits the entry and participation not only of public figures with controversial views but the vast majority of people in our society. Senators like Tom Cotton have every right to have their views published in a newspaper. But they have no specific right to have those views published by any particular publication. Rather, publications have the rightboth constitutionally as institutions of the press, and by convention as collections of individuals engaged in lawful projectsto decide what and whom they would or would not like to publish, based on whatever standards happen to prevail within each outlet.

When a speaker is denied or when staffers at a publication argue that something should not have been published, the rights of the parties in question havent been violated in any way. But what we tend to hear in these and similar situations are criticisms that are at odds with the principle that groups in liberal society have the general right to commit themselves to values which many might disagree with and make decisions on that basis. Theres nothing unreasonable about criticizing the substance of such decisions and the values that produce them. But accusations of illiberalism in these cases carry the implication that nonstate institutions under liberalism have an obligation of some sort to be maximally permissive of opposing ideasor at least maximally permissive of the kinds of ideas critics of progressive identity politics consider important. In fact, they do not.

Associative freedom is no less vital to liberalism than the other freedoms, and is actually integral to their functioning. There isnt a right explicitly enumerated in the First Amendment that isnt implicitly dependent on or augmented by similarly minded individuals having the right to come together. Most people worship with others; an assembly or petition of one isnt worth much; the institutions of the press are, again, associations; and individual speech is functionally inert unless some group chooses to offer a venue or a platform. And political speech is, in the first place, generally aimed at stirring some group or constituency to contemplation or action.

Ultimately, associative freedom is critical because groups and associations are the very building blocks of society. Political parties and unions, nonprofits and civic organizations, whole religions and whole ideologiesindividuals cannot be meaningfully free unless they have the freedom to create, make themselves part of, and define these and other kinds of affiliations. Some of our affiliations, including the major identity categories, are involuntary, and this is among the complications that makes associative freedom as messy as it is important. Just as the principle of free speech forces us into debates over hate speech, obscenity, and misinformation, association is the root of identity-based discrimination and other ills. The Supreme Courts decision in Bostock v. Clayton County banning employment discrimination on the basis of LGBTQ identity last month was a huge step forward, but in practice, workers of all stripes often lack the means and opportunity to defend themselves from unjust firingsall the more reason for those preoccupied with cancel culture and social mediadriven dismissals to support just-cause provisions and an end to at-will employment.

What about the oft-repeated charge that progressives today intend to establish group rights over and above the rights of the individualthat, specifically, minorities and certain disadvantaged groups are to be given more rights than, and held as superior to, white people? If this were the case, the critics of left illiberalism would truly be onto something: Individual rights are, again, at the center of liberal thought.

But that divergence isnt anywhere to be found in any of the major controversies that have recently captured broad attention. A minority chef who says she wants to be paid as much as her white colleagues has not said that white people are inferior; an unarmed black man under the knee of a policeman and begging for his life is not asking to be conferred a special privilege. The goal is parity, not superiority. The heart of the protests and cultural agitation weve witnessed has clearly been a desire to see minorities treated equallysharing the rights to which all people are entitled but that have been denied to many by societys extant bigots and the residual effects of injustices past.

Ultimately, its the realities of our collective past that make the notion that progressives are dragging the country toward illiberalism especially ridiculous. Over the course of two and a half centuries in this country, millions of human beings held as property toiled for the comfort and profit of already wealthy people who tortured and raped them. Just over 150 years ago, the last generation of slaves was released into systems of subjugation from which its descendants have not recovered. August will mark just 100 years since women were granted the right to vote; Black Americans, nominally awarded that right during Reconstruction, couldnt take full advantage of it until the passage of the Voting Rights Act in 1965. The litany of other inequities and crimes our country has perpetrated and continues to perpetrate against Native Americans, immigrants, religious and sexual minorities, political dissidents, and the poor is endless. All told, liberal society in the U.S. is, at best, just over half a century old: If it were a person, it would be too young to qualify for Medicare.

See the original post:
The Willful Blindness of Reactionary Liberalism - The New Republic

Here are five things you need to know about the coronavirus outbreak this Monday evening. We will have another update for you on Tuesday morning.

The 1.57bn emergency support package unveiled today for the culture sector has been warmly welcomed by many arts leaders but it will not be enough to save every job, Culture Secretary Oliver Dowden has said. We do not yet know how the money will be divided but the government's priority is to preserve "crown jewels". One theatre has offered an insight into how it will apply social distancing.

Coronavirus restrictions may have eased but sandwich chain Pret A Manger is the latest High Street company to announce shop closures and job cuts as it struggles to cope with the pandemic. Pret is reliant on sales from commuters and lunchtime office workers - both sources of revenue acutely hit by the lockdown.

No new deaths of people with coronavirus have been reported by Public Health Wales for the first day since March. However, BBC Wales health correspondent Owain Clarke points out that given the way the figures are compiled - tagged on to the actual date of death once reported - there have been previous days where the statistics show no Covid-19 deaths had occurred in Wales.

Northern Ireland is seeing a major easing of lockdown restrictions today. Barbers, hairdressers, tattoo parlours and nail salons are now allowed to reopen. Visiting rules at hospitals and care homes have also been eased, meaning many people can visit loved ones for the first time in months.

Three partially sighted and blind people have asked for others to be "understanding" as they try to navigate shops and High Streets in a socially distanced UK. Sue Baker, Reverend Simon Stokes and Mark Smith spoke of their experiences in the city of Norwich and said social distancing was taking away their independence.

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Continued here:
Coronavirus: Arts job fears, NI lockdown eases and coping with blindness - BBC News

A hand sanitiser is being recalled after it was found to contain potentially lethal chemicals.

The alert was issued yesterday (July 7) by The Chartered Trading Standards Institute for Shield Hand Sanitiser Gel.

Not only is the product ineffective at killing bacteria or viruses, but it contains the toxic substance methanol and is believed to be a fire risk.

Made in the UK, the 100ml gel is packaged in a plastic bottle and is available in different colour, with a black or white self-closing cap.

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It has reportedly been sold online, particularly via eBay.

The alert, classed as serious, says: "The product contains an insufficient amount of ethanol and propan-2-ol (measured values: ? 0.05% and ? 0.1%, respectively).

"Consequently, it does not kill bacteria or viruses, which could then reach the user, increasing the risk of infection.

"The product does contain methanol (measured value: 3.4%), which is acutely toxic to the central nervous system and the eye.

"Ingestion or contact with methanol leads to blindness and death.

"Furthermore, the presence of methanol is not accompanied by the corresponding hazard pictograms and warnings.

"Users have therefore no information on the toxicity and flammability of the product, which in the presence of an ignition source, could lead to a fire."

If you have seen or heard anything you think we should know about, or in relation to this, please contact the Kent Live newsdesk by email at kentlivenewsdesk@reachplc.com.

Alternatively, you can get in touch with us via our Facebook page or on Twitter @kentlivenews.

Original post:
Toxic hand sanitiser urgently recalled over blindness and death fears - Kent Live

We all love monsoons - hot and piping pakoras, long drives and the earthy scent of petrichor. But this lovely weather is also associated with a host of water and foodborne diseases including malaria, jaundice, leptospirosis, flu and diarrhoea. Not just this, the rainy season also invites a host of eye infections.As we all know, among eye infections, conjunctivitis is the most common one. Doctors report a sharp rise in eye infection during this humid weather. Three common types of eye infectionsConjunctivitisCommonly known as pink eye, conjunctivitis is the most common type of eye infection. Common symptoms include red eyes, discharge from the eyes. The infection can be easily spread from one person to another by touch.

KeratitisKeratitis is the infection of the cornea. The infection is caused by injury to the eyes caused due to unhygienic routine of contact lens. If left unattended, the infection can even lead to blindness.

TrachomaTrachoma is caused by bacterium chlamydia trachomatis. The infection is responsible for blindness in almost 1.9 million people across the globe. The blindness caused by trachoma is irreversible. It can be caused through direct touch or towels and flies that have come in contact with the eyes or nose of an infected person.

Other sources of contamination can include soil, uncooked meal and unwashed vegetables.

Tips to prevent eye infections- Wash your hands with soap and water frequently.

- Separate your towels, linens, clothes and bedsheets from other people in the family.

- Do not wear contact lenses while swimming. If you use them by mistake, get a new pair.

- Maintain good contact lens hygiene. Wash your hands thoroughly before wearing and taking off lenses.

- If you are trekking or cycling through the forest, wear protective eye gear.

- Take a bath from warm water if you get drenched in rain.

- If you feel any discomfort in eyes, seek medical help. Do not self-medicate.

- If you have already caught the infection, here are some tips to follow

- If you have already caught the infection, wear glasses or a face shield.

- Use boiled or filtered water to wash your eyes.

Read the original here:
3 types of eye infections and tips to prevent them during monsoon - Times of India

PITTSBURGH (KDKA) The Food and Drug Administration is recalling hand sanitizers with methanol, a hazardous ingredient.

And poison control centers are getting calls.

I do know poison control centers around the country have been, says Dr. Tony Pizon of The Pittsburgh Poison Center.

The FDA is also seeing hand sanitizers labeled as containing ethanol, or ethyl alcohol, but theyre contaminated with methanol. This type of alcohol can be used as a pesticide, a solvent or fuel.

It can be absorbed through the skin but is more dangerous if ingested.

There is a chance of absorbing it through your skin or inhaling the fumes that can cause minor toxicity, says Dr. Pizon. If youre just using hand sanitizer like using hand sanitizer, youre not likely to develop toxicity.

You need to be careful, it being around children and pets because we know ingesting the product is much more serious, says Dr. Matthew Stripp, AHN Director of Toxicology.

Methanol can cause nausea, vomiting, headache, seizures, coma and more.

There have actually been a couple of deaths reported, Dr. Pizon said. There have been several cases of blindness reported, as well.

The body tends to turn this type of alcohol, which is different than the alcohol and wine, beer, and liquor, it turns it into a toxic byproduct. And that can make your blood acidic, and it can do damage to your brain, Dr. Stripp said.

Luckily, methanol poisoning, if caught early, can be treated with IV fluids and medicines.

The end treatment would be dialysis to remove the methanol and the metabolites that caused the blindness, says Dr. Pizon.

Washing your hands with soap and water should be your first choice. If thats not possible, use hand sanitizer. But shop safely. You cant see or smell methanol.

The common feature among the tainted products?

Largely made in Mexico. Those would be the ones to avoid, Dr. Pizon said. Reputable brands made in the United States are really the way to ensure safety.

The FDA has recalled three products and has advised against using 13 others.

For a complete list, click here and here.

Read this article:
Some Hand Sanitizers On The Market May Be Dangerous - CBS Pittsburgh

The "Diabetic Retinopathy Market - Growth, Trends, and Forecasts (2020 - 2025)" report has been added to ResearchAndMarkets.com's offering.

Certain factors that are driving the market growth include the rising prevalence of diabetes and blindness due to the same, growing geriatric population base, increasing technological advancements in diabetic retinopathy surgical instruments.

There is an increasing burden of diabetic retinopathy across the globe. As stated by the International Diabetes Federation (IDF), the global prevalence of DR from 2015 to 2019 was around 27%. The lowest prevalence was in Europe at 20.6% and South East Asia at 12.5% and highest in Africa at 33.8%, Middle East and North Africa 33.8%, and the Western Pacific region at 36.2%.

Hence, the rising prevalence of DR, along with the growing awareness and concern over it, are expected to drive the market growth over the forecast period.

Key Market Trends

Proliferative diabetic retinopathy is Expected to Hold Significant Market Share in the Type Segment

Proliferative diabetic retinopathy (PDR): PDR is the most advanced stage of diabetic retinopathy. At this stage, circulation problems deprive the retina of oxygen. As a result, new, fragile blood vessels can begin to grow in the retina and into the vitreous, the gel-like fluid that fills the back of the eye. The new blood vessels may leak blood into the vitreous, clouding vision.

Symptoms include progressive loss of vision, particularly in those who are not properly followed or treated. The major risk factors for PDR include the duration of diabetes, since 30-34 years of diabetes increase the risk of retinopathy by 65%, according to the reports published by the Columbia University. Hence, the rising prevalence of diabetes is directly contributing to a further increase in the prevalence of PDR.

North America Dominates the Market and Expected to do Same in the Forecast Period

Over the past decade, the prevalence of diabetes in North America has increased. People with diabetes are at risk for diabetic retinopathy. Diabetic retinopathy is the leading cause of new cases of blindness among adults aged 20 to 74 years in the United States. More than 100 million U.S. adults are now living with diabetes or prediabetes, according to a new report published by the Centers for Disease Control and Prevention (CDC). Hence with the increasing number of people living with diabetes is expected to contribute to market growth across the entire region.

Competitive Landscape

The global Diabetic Retinopathy market is moderately competitive and consists of a few major players. Companies like Alimera Sciences, Allergan plc, BCN Peptides, Genentech, Glycadia Pharmaceuticals, Kowa Group, Novartis AG, Oxurion N.V., Regeneron Pharmaceuticals Inc, among others, which hold the substantial market share in the Diabetic Retinopathy market.

Key Topics Covered

1 INTRODUCTION

1.1 Study Deliverables

1.2 Study Assumptions

1.3 Scope of the Study

2 RESEARCH METHODOLOGY

3 EXECUTIVE SUMMARY

4 MARKET DYNAMICS

4.1 Market Overview

4.2 Market Drivers

4.2.1 Rising Prevalence of Diabetes and Blindness due to the Same

4.2.2 Growing Geriatric Population Base

4.2.3 Increasing Technological Advancements in Diabetic Retinopathy Surgical Instruments

4.3 Market Restraints

4.3.1 Lack of Skilled Ophthalmologists

4.3.2 Extended Approval Time for Drugs

4.4 Porter's Five Force Analysis

4.4.1 Threat of New Entrants

4.4.2 Bargaining Power of Buyers/Consumers

4.4.3 Bargaining Power of Suppliers

4.4.4 Threat of Substitute Products

4.4.5 Intensity of Competitive Rivalry

5 MARKET SEGMENTATION

5.1 By Type

5.1.1 Proliferative Diabetic Retinopathy

5.1.2 Non-proliferative Retinopathy

5.2 By Management Approach

5.2.1 Anti-VEGF Drug

5.2.2 Intraocular Steroid Injection

5.2.3 Laser Surgery

5.2.4 Vitrectomy

5.3 Geography

5.3.1 North America

5.3.2 Europe

5.3.3 Asia-Pacific

5.3.4 Middle-East & Africa

5.3.5 South America

6 COMPETITIVE LANDSCAPE

6.1 Company Profiles

6.1.1 Alimera Sciences

6.1.2 AbbVie Inc. (Allergan plc)

6.1.3 BCN Peptides

6.1.4 Genentech

6.1.5 Glycadia Pharmaceuticals

6.1.6 Kowa Group

6.1.7 Novartis AG

6.1.8 Regeneron Pharmaceuticals Inc

6.1.9 Oxurion N.V.

7 MARKET OPPORTUNITIES AND FUTURE TRENDS

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World Diabetic Retinopathy Market 2020-2025 - Rising Prevalence of DR Along With Growing Awareness and Concerns - ResearchAndMarkets.com - Yahoo...

WALTHAM Mass., July 07, 2020 (GLOBE NEWSWIRE) -- Apellis PharmaceuticalsInc., (NASDAQ:APLS), a global biopharmaceutical company pioneering targeted C3 therapies, today announced that it completed enrollment in the Phase 3 DERBY and OAKS studies investigating intravitreal pegcetacoplan (APL-2), a targeted C3 therapy, for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). GA causes blindness and is a progressive complement-driven eye disease1,2 that affects approximately five million people globally.3,4 There are no approved therapies for GA.

Completing enrollment in the Phase 3 DERBY and OAKS studies is a critical milestone that moves us one step closer to bringing the first treatment for geographic atrophy to patients. We are extremely grateful to all patients participating in these groundbreaking studies, said Federico Grossi, M.D., Ph.D., Chief Medical Officer of Apellis. People living with GA need a treatment and we believetargeting the complement system at C3 with pegcetacoplan has the potential to control the excessive complement activation that drives the irreversible growth of GA lesions that cause blindness. We look forward to seeing top-line results in the third quarter of 2021.

A total of 1,259 patients are enrolled in DERBY and OAKS, which are pivotal randomized Phase 3 studies designed to compare the efficacy and safety of intravitreal pegcetacoplan with sham treatment in patients with GA secondary to AMD. The primary objective of the studies is to evaluate the reduction in growth of GA lesion size, measured by fundus autofluorescence (FAF) at month 12 compared to baseline.

Geographic atrophy leads to irreversible vision loss, a decline in the quality of life, and remains a major unmet need for our patients. Achieving this critical milestone reflects the importance of bringing this targeted C3 therapy to our GA patients. I want to thank my co-investigators for completing the enrollment of DERBY and OAKS, especially during the ongoing pandemic. I look forward to seeing the results next year with the hope that pegcetacoplan willenable clinicians to treat this debilitating disease,said Jeffrey S. Heier, MD, Principal Investigator of the DERBY study and Co-President & Medical Director,Director of Retinal Research,Ophthalmic Consultants of Boston.

In July 2018, the U.S. Food and Drug Administration (FDA) granted pegcetacoplan Fast Track Designation for the treatment of GA. The Phase 3 DERBY and OAKS studies were initiated based on positive results from the Phase 2 FILLY study, which showed that monthly pegcetacoplan treatment resulted in a 29% (p=0.008) reduction in the rate of GA lesion growth compared to sham injections at 12 months.

For more information about the DERBY and OAKS studies, visit http://www.clinicaltrials.gov: (NCT03525600) and (NCT03525613).

About Pegcetacoplan (APL-2)Pegcetacoplan is the only investigational targeted C3 therapy in late-stage clinical trials. It is designed to control excessive complement activation, which can lead to the onset and progression of many serious diseases. Pegcetacoplan is a synthetic cyclic peptide conjugated to a polyethylene glycol polymer that binds specifically to C3 and C3b.Apellis is evaluating pegcetacoplan in several clinical studies including geographic atrophy (GA), paroxysmal nocturnal hemoglobinuria (PNH), cold agglutinin disease, and C3 glomerulopathy. Pegcetacoplan was granted Fast Track designation by the U.S. Food and Drug Administration (FDA) for the treatment of GA and the treatment of PNH. For additional information regarding our clinical trials, visithttps://apellis.com/our-science/clinical-trials/.

About Geographic Atrophy (GA) GA is an advanced form of age-related macular degeneration (AMD), the leading cause of blindness. Excessive complement activation drives the irreversible lesion growth in GA5, and C3 is the only target to precisely control complement overactivation. Pegcetacoplan, studied in early and late-stage trials comprising a total of approximately 1500 patients, is the only targeted C3 inhibitor being evaluated in patients to control lesion growth in GA.6

GA lesions affect the central portion of the retina, known as the macula, which is responsible for central vision. GA is progressive and irreversible, leading to central visual impairment and permanent loss of vision. Based on published studies, approximately one million people have GA inthe United States and 5 million people have GA globally.1,2 There are currently noapproved treatments for GA.

About DERBY and OAKSDERBY (621 patients enrolled) and OAKS (638 patients enrolled) are Phase 3, multicenter, randomized, double-masked, sham-controlled studies to compare the efficacy and safety of intravitreal pegcetacoplan with sham injections in patients with GA secondary to AMD. The primary objective of the studies is to evaluate the efficacy of pegcetacoplan compared to sham injection in patients with GA secondary to AMD assessed by change in the total area of GA lesions from baseline as measured by fundus autofluorescence (FAF).

About FILLYThe FILLY study was a 246-patient, Phase 2, multicenter, randomized, single-masked, sham-controlled clinical trial evaluating pegcetacoplan in patients with GA secondary to AMD conducted at over 40 clinical sites in the United States, Australia and New Zealand. Pegcetacoplan was administered as an intravitreal injection monthly or every other month (EOM) for 12 months, followed by six months of monitoring after the end of treatment. The primary efficacy endpoint was the change in GA lesion area from baseline to month 12 compared to sham.

In this study, pegcetacoplan met its primary endpoint of reducing the growth rate of the GA lesion (measured as square root transformation of GA lesion area) compared to sham after 12 months of treatment. Pegcetacoplan administered monthly via intravitreal injection showed a 29% (p=0.008) reduction in the rate of GA lesion growth compared to sham after 12 months of treatment. With every other month administration of pegcetacoplan, a 20% (p=0.067) reduction was observed compared to sham. Statistical significance was defined as p<0.1 for this study.

Pegcetacoplan was generally well-tolerated in the Phase 2 FILLY trial. Over the full 18-month study period, a total of 26 cases of exudative AMD were reported by the investigators. These were seen more frequently in the pegcetacoplan-treated patients (18 in the monthly treatment group, 7 in the every other month treatment group and 1 in the sham control group). No negative impact on visual acuity was observed. The results of the FILLY study were published in Ophthalmology, the journal of the American Academy of Ophthalmology.

About ApellisApellis Pharmaceuticals, Inc.is a clinical-stage biopharmaceutical company focused on the development of novel therapeutic compounds for the treatment of a broad range of life-threatening or debilitating autoimmune diseases based upon complement immunotherapy through the inhibition of the complement system at the level of C3. Apellis is the first company to advance chronic therapy with a C3 inhibitor into clinical trials. For additional information about Apellis and pegcetacoplan, please visithttp://www.apellis.com.

Apellis Forward-Looking StatementStatements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements relating to the implications of preliminary clinical data. The words anticipate, believe, continue, could, estimate, expect, intend, may, plan, potential, predict, project, should, target, will, would and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: whether the companys clinical trials will be fully enrolled and completed when anticipated; whether preliminary or interim results from a clinical trial will be predictive of the final results of the trial; whether results obtained in preclinical studies and clinical trials will be indicative of results that will be generated in future clinical trials; whether pegcetacoplan will successfully advance through the clinical trial process on a timely basis, or at all; whether the results of the companys clinical trials will warrant regulatory submissions and whether pegcetacoplan will receive approval from the FDA or equivalent foreign regulatory agencies for GA, PNH, CAD, C3G or any other indication when expected or at all; whether, if Apellis products receive approval, they will be successfully distributed and marketed; and other factors discussed in the Risk Factors section of Apellis Quarterly Report on Form 10-Q filed with theSecurities and Exchange CommissiononApril 29, 2020and the risks described in other filings that Apellis may make with theSecurities and Exchange Commission. Any forward-looking statements contained in this press release speak only as of the date hereof, and Apellis specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise.

Media Contact:Mark Dolemedia@apellis.com617.997.3484

Investor Contact: Sam Martin/Maghan MeyersArgot Partnerssam@argotpartners.com/maghan@argotpartners.com212.600.1902

_______________________________________

1 Weber, BHF, Issa, PC, et al. The Role of the Complement System in Age-Related Macular Degeneration. Dtsch Arztebl Int 2014; 111(8): 1338. 2 Heesterbeek, TJ, Lechanteur YTE, et al. Complement activation levels are related to disease stage in AMD. Invest Ophthalmol Vis Sci. 2020;61(3):18. 3 Rudnicka AR, Jarrar Z, Wormald R, et al. Age and gender variations inage-related macular degenerationprevalence in populations of European ancestry: a meta-analysis. Ophthalmology 2012;119:571580.4 Wong WL, Su X, Li X, et al. Global prevalence ofage-related macular degenerationand disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health 2014;2:e106116.5 Seddon, JM, Rosner, B. Validated prediction models for macular degeneration progression and predictors of visual acuity loss identify high-risk individuals. Am J Ophthalmol 2019;198:223261. 6Yates, JRW, Sepp T, et al. Complement C3 Variant and the Risk of Age-Related Macular Degeneration. N Engl J Med 2007;357.

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Apellis Completes Enrollment in Two Phase 3 Studies of the Targeted C3 Therapy, Pegcetacoplan, in Patients with Geographic Atrophy (GA) -...

Inherited retinal diseases marketis expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market to account to an annual growth rate of 4.40% in the above-mentioned forecast period. The growing awareness amongst the physicians and patients regarding the benefits associated with the usage of inherited retinal diseases has been directly impacting the growth of inherited retinal diseases market.

The inherited retinal diseases market document provides CAGR values along with its fluctuations for the definite forecast period. Pharmaceutical industry can achieve great benefits with this inherited retinal diseases market research report which brings market and competitive landscape clearly into the focus and assist to make better decisions. Thus, the all-inclusive market information and data of the inherited retinal diseases market document will surely grow business and improve return on investment (ROI). Market definition included in the report provides the scope of particular product with respect to the driving factors and restraints in the market. The key research methodology used here by DBMR research team is data triangulation which involves data mining, analysis of the impact of data variables on the market, and primary validation.

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The major players covered in the inherited retinal diseases market report are American Society of Gene & Cell Therapy, Spark Therapeutics, Inc., Invitae Corporation., The Choroideremia Research Foundation Inc, American Council of the Blind, Foundation Fighting Blindness, Guide Dogs for the Blind, Inc., Fighting Blindness, FIGHTING BLINDNESS CANADA, Lighthouse Guild, The RDH12 Fund For Sight, Sofia Sees Hope, Retina International, Usher Syndrome Coalition, VisionServe Alliance among other domestic and global players. Market share data is available for global, North America, Europe, Asia-Pacific (APAC), Middle East and Africa (MEA) and South America separately. DBMR analysts understand competitive strengths and provide competitive analysis for each competitor separately.

Some of the Main regions covered in this report are

This Inherited Retinal Diseases report includes the Market Dynamics which analyzes the drivers and restraints of the market and takes into account the various factors such as market obstacles, logistics, political and regulatory constraints or policy support. The most relevant factors are identified and qualitatively described in this Section.

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Global Inherited Retinal Diseases Market Scope and Market Size

Inherited retinal diseases market is segmented on the basis of type, treatment type and distribution channel. The growth amongst these segments will help you analyse meagre growth segments in the industries, and provide the users with valuable market overview and market insights to help them in making strategic decisions for identification of core market applications.

Based on type, inherited retinal diseases market is segmented into leber congenital amaurosis (LCA), retinitis pigmentosa, choroideremia, stargardts disease, and achromatopsia.

Inherited retinal diseases market has also been segmented based on treatment type such as gene therapy treatment, and symptomatic treatment.On the basis of distribution channel, the inherited retinal diseases market is segmented into hospital pharmacies, and retail pharmacies.

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1. Comprehensive quantitative analysis of the industry is provided for the period of 2019-2026 to assist stakeholders to capitalize on the prevailing market opportunities.2. Comprehensive analysis of the factors that drive and restrict the market growth is provided in the report.3. Comprehensive quantitative analysis of the industry is provided for the period of 2019-2026 to assist stakeholders to capitalize on the prevailing market opportunities.4. Extensive analysis of the key segments of the industry helps in understanding the trends in types of Inherited Retinal Diseases across global.5. To get a comprehensive overview of the Inherited Retinal Diseases market.

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Global Inherited Retinal Diseases Market Research & Clinical Advancements by 2027| Invitae Corporation., The Choroideremia Research Foundation...

For the second straight day, Catawba County Public Health Wednesday (July 8) reported 35 new cases of COVID-19, increasing the total to 1,081, with 14 deaths. Hospitalizations dropped to 16, from a pandemic high of 20 on Tuesday (July 7). 492 patients had recovered from the coronavirus in Catawba County and there had been 3,686 negative test results.

Catawba County Public Health is investigating a newly identified outbreak of COVID-19 at Abernethy Laurels in Newton, where three residents and two staff members have tested positive for the virus. The facility is informing patients, their family members, and staff about the situation.

This is the sixth congregate care facility outbreak identified in Catawba County. In a congregate living setting, a COVID-19 outbreak is defined as two or more laboratory-confirmed cases. The facility previously responded to an outbreak that involved three individuals. That outbreak has since resolved.

The Caldwell County Health Department reported 29 new cases of COVID-19, increasing the overall total to 555, with six deaths. 16 Caldwell County coronavirus patients were hospitalized and at least 301 had recovered.

A third COVID-19 outbreak has been confirmed in Caldwell County. Two employees at Hickory Falls Health and Rehabilitation tested positive for COVID-19. Eight more positive cases were reported at Brockford Inn Assisted Living. The facility currently has 40 residents and 18 employees who have tested positive for the virus. In congregate living settings, an outbreak of COVID-19 is defined as two or more laboratory-confirmed cases within 28 days.

15 new cases of COVID-19 were reported in Burke County Wednesday, increasing the overall total to 1,116, with 20 deaths. There were seven people hospitalized with the coronavirus in Burke County, and at least 851 patients had recovered.

Wednesday's media briefing from Burke County included an update from North Carolina Department of Health and Human Services regarding hand sanitizer safety. A news release was sent out to warn residents about methanol-contaminated hand sanitizers. Methanol is a toxic alcohol that can cause blindness and/or death when absorbed through the skin or when swallowed. No alcohol-based hand sanitizers should ever be ingested.

Manufacturers and distributors are working on a voluntary recall of products that have a significant amount of methanol. There has been an increase in products manufactured in Mexico that are labeled to contain ethanol, whish is normal alcohol used in hand sanitizer, but was tested positive for methanol contamination. Get more details at this link: https://www.ncdhhs.gov/news/press-releases/public-health-risk-associated-methanol-contaminated-hand-sanitizers

The North Carolina Department of Health and Human Services on Wednesday reported 138 cases of COVID-19 in Alexander County, two more than the previous update issued by county health officials. Through Wednesday, there had been one coronavirus-related death in Alexander County.

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Thursday COVID-19 Update: Two More Outbreaks Reported In Hickory Metro, New Cases Added In All Counties - WHKY

If we could start 2020 all over again, the world would be satisfied if the big worry was wildfires and whether or not cat litter had a Non-GMO Project label.

Instead, we got a coronavirus from Wuhan, China, and a COVID-19 disease that isn't stopping any time soon.But science marches on, and we also have machine learning helping to grow artificial organs.

The human retina has a very limited capacity for regeneration. Any progressive loss of neurons, such as in glaucoma, inevitably leads to complete loss of vision. There is nothing a physician can recommend to halt it. But science is on the case. In a recent study, a neural network capable of recognizing retinal tissues during the process of differentiation does so without the need to modify cells, making it ideal for growing retinal tissue for developing cell replacement therapies to treat blindness and conducting research into new drugs.

Credit: MIPT Press Office

That's more complex than it reads at first. In multicellular organisms, the cells making up different organs and tissues start the same, but then acquire distinct functions and properties in the course of development. Stem cells have the potential to become any kind of cell, they undergo differentiation by producing proteins specific to certain tissues and organs.

The most advanced technique for replicating tissue differentiation in vitro relies on 3-D cell aggregates called organoids. Since organoid-based differentiation closely mimics natural processes, the resulting tissue is very similar to the one in an actual biological organ. Some of the stages in cell differentiation toward retina have a stochastic (random) nature, leading to considerable variations in the number of cells with a particular function even between artificial organs in the same batch. The discrepancy is even greater when different cell lines are involved. As a result, it is necessary to have a means of determining which cells have already differentiated at a given point in time. Otherwise, experiments will not be truly replicable, making clinical applications less reliable, too.

To spot differentiated cells, tissue engineers use fluorescent proteins. By inserting the gene responsible for the production of such a protein into the DNA of cells, researchers ensure that it is synthesized and produces a signal once a certain stage in cell development has been reached. While this technique is highly sensitive, specific, and convenient for quantitative assessments, it is not suitable for cells intended for transplantation or hereditary disease modeling.

To address that pitfall, the authors of the recent study proposed an alternative approach based on tissue structure. No reliable and objective criteria for predicting the quality of differentiated cells have been formulated so far. The researchers proposed that the best retinal tissues, those most suitable for transplantation, drug screening, or disease modeling, should be selected using neural networks and artificial intelligence.

The team trained a neural network - a computer algorithm that mimics the way neurons work in the human brain - to identify the tissues in a developing retina based on photographs made by a conventional light microscope. The researchers first had a number of experts identify the differentiated cells in 1,200 images via an accurate technique that involves the use of a fluorescent reporter. The neural network was trained on 750 images, with another 150 used for validation and 250 for testing predictions. At this last stage, the machine was able to spot differentiated cells with an 84% accuracy, compared with 67% achieved by humans.

"Our findings indicate that the current criteria used for early-stage retinal tissue selection may be subjective. They depend on the expert making the decision. However, we hypothesized that the tissue morphology, its structure, contains clues that enable predicting retinal differentiation, even at very early stages. And unlike a human, the computer program can extract that information!" states Evgenii Kegeles of the Moscow Institute of Physics and Technology. "This approach does not require images of a very high quality, fluorescent reporters, or dyes, making it relatively easy to implement. It takes us one step closer to developing cellular therapies for the retinal diseases such as glaucoma and macular degeneration, which today invariably lead to blindness. Besides that, the approach can be transferred not just to other cell lines, but also to other human artificial organs."

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Neural Networks Growing Artificial Organs Is The 2020 We Expected Decades Ago - Science 2.0

But however well-intentioned, there are complications that come with works that aim to use colorblind casting to highlight people of color who wouldnt otherwise be represented. Creators may cast blind, thinking their job done, failing to consider that a Black man cast as a criminal or a Latina woman cast as a saucy seductress even when cast without any regard to their race can still be problematic. One kind of blindness can lead to another.

And then theres also the Hamilton problem. The show may place diverse bodies on the stage, but productions that would subvert a narrative traditionally owned by white characters must not just tag in actors of color but reconsider the fundamental way the new casting changes the story. In Hamilton, the revision of American history is dazzling and important, but it also neglects and negates the parts of the original story that dont fit so nicely into this narrow model. The characters relationship to slavery, for example, is scarcely mentioned, because it would be incongruous with the triumphant recasting of our countrys first leaders. (The Hamilton star and creator Lin-Manuel Miranda responded to this criticism this week, calling it valid.)

The trouble of a colorblind production might not be the casting itself, but the fact that the casting may still erase the reimagined characters identities. (If Willy Loman is Black, wouldnt he have a more complex understanding of the American dream?) Careless colorblind casting in animated roles, in live-action roles on TV, movies or the stage assumes that identities amount to nothing and that all experiences are transferable, which is far from the reality.

In a 1996 speech, the playwright August Wilson spoke out against colorblind casting overall, saying:

To mount an all-Black production of a Death of a Salesman or any other play conceived for white actors as an investigation of the human condition through the specifics of white culture is to deny us our own humanity, our own history, and the need to make our own investigations from the cultural ground on which we stand as Black Americans. It is an assault on our presence, and our difficult but honorable history in America; and it is an insult to our intelligence, our playwrights, and our many and varied contributions to the society and the world at large.

Wilson called not for colorblind casting, but for institutions that invite art by and for people of color, to tell their own stories and not simply ones adapted for them. He doesnt call for blindness, but visibility: people of color seen on stages and behind the curtains. This applies to all art forms people of color should be on movie screens, on the TV and in recording booths giving voice to stories about them.

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Hamilton, The Simpsons and the Problem With Colorblind Casting - The New York Times

Burnley wore a one-off all white fourth strip in the win over West Ham United on Wednesday night.

The Clarets have produced the strip after the Premier League flagged a colour clash between the two sides.

Burnleys home and away strips are a natural clash with the Hammers claret and blue kit while the Turf Moor sides green third kit has been deemed a clash by the Premier League system, which does take into account the impact on colour blind viewers.

The league try to ensure four different colours between the two teams - outfielders and goalkeepers - to ensure a contrast.

This includes avoiding a clash of red and green where possible, something that assists viewers watching the game who are colour blind.

The Premier League said Burnley were notified last summer in advance of the season starting that a new kit would be required and a white strip was agreed.

Burnley were able to play in green at Aston Villa as there was sufficient contrast on Villas shirt whereas West Hams is deemed all Claret - hence the change.

And the Clarets have a 100 per cent record in their new kit after Jay Rodriguez's goal gave them all three points.

Colour blindness, or colour vision deficiency, is one of the worlds most common genetic conditions but it is under-recognised and poorly understood. Worldwide, about 320 million people have some form of colour blindness and in the UK there are almost three million colour-blind people. Men are more likely to be colour blind than women, as approximately one in 12 men (8 per cent) inherit red/green colour blindness but only 1 in 200 (0.5%) of women do.

As a result colour-blindness leads to issues in football for people who are colour-blind, including kit clashes between players, goalkeepers, match officials, the playing surface; equipment such as match balls; venues, information and also TV coverage of the match itself.

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Why Burnley wore a white kit in their Premier League match with West Ham - Accrington Observer

Diabetes can affect many parts of your body, including your skin. When diabetes affects the skin, its often a sign that your blood sugar (glucose) levels are too high. This could mean that:

You have undiagnosed diabetes, or pre-diabetes

Your treatment for diabetes needs to be adjusted

If you notice any of the following warning signs on your skin, its time to talk with your doctor.

This skin condition often begins as small raised solid bumps that look like pimples. As it progresses, these bumps turn into patches of swollen and hard skin. The patches can be yellow, reddish, or brown.

You may also notice:The surrounding skin has a shiny porcelain-like appearance

A dark patch (or band) of velvety skin on the back of your neck, armpit, groin, or elsewhere could mean that you have too much insulin in your blood. This is often a sign of prediabetes.The medical name for this skin condition is acanthosis nigricans.

Often causing darker skin in the creases of the neck, AN may be the first sign that someone has diabetes.

When this develops on the fingers, toes, or both, the medical name for this condition is digital sclerosis.

On the hands, youll notice tight, waxy skin on the backs of your hands. The fingers can become stiff and difficult to move. If diabetes has been poorly controlled for years, it can feel like you have pebbles in your fingertips.

Hard, thick, and swollen-looking skin can spread, appearing on the forearms and upper arms. It can also develop on the upper back, shoulders, and neck. Sometimes, the thickening skin spreads to the face, shoulders, and chest.

In rare cases, the skin over the knees, ankles, or elbows also thickens, making it difficult to straighten your leg, point your foot, or bend your arm. Wherever it appears, the thickened skin often has the texture of an orange peel.

This skin problem usually develops in people who have complications due to diabetes or diabetes that is difficult to treat.

Its rare, but people with diabetes can see blisters suddenly appear on their skin. You may see a large blister, a group of blisters, or both. The blisters tend to form on the hands, feet, legs, or forearms and look like the blisters that appear after a serious burn. Unlike the blisters that develop after a burn, these blisters are not painful.

Large blisters like this one can form on the skin of people who have diabetes.

The medical name for this condition is bullosis diabetricorum. Sometimes, its called diabetic bullae.

People who have diabetes tend to get skin infections. If you have a skin infection, youll notice one or more of the following:Hot, swollen skin that is painful

Has it been a year or longer since your last period, and do you get several yeast infections each year? Its possible that you have diabetes or pre-diabetes.

Having high blood sugar (glucose) for a long time can lead to poor circulation and nerve damage. You may have developed these if youve had uncontrolled (or poorly controlled) diabetes for a long time.

Poor circulation and nerve damage can make it hard for your body to heal wounds. This is especially true on the feet. These open wounds are called diabetic ulcers.

If you have diabetes, you should check your feet every day for sores and open wounds.

This skin condition causes spots (and sometimes lines) that create a barely noticeable depression in the skin. Its common in people who have diabetes. The medical name is diabetic dermopathy. It usually forms on the shins. In rare cases, youll see it on the arms, thighs, trunk, or other areas of the body.

Diabetic dermopathy: This 55-year-old man has had diabetes for many years.

The spots are often brown and cause no symptoms. For these reasons, many people mistake them for age spots. Unlike age spots, these spots and lines usually start to fade after 18 to 24 months. Diabetic dermopathy can also stay on the skin indefinitely.

When these bumps appear, they often look like pimples. Unlike pimples, they soon develop a yellowish color. Youll usually find these bumps on the buttocks, thighs, crooks of the elbows, or backs of the knees. They can form anywhere though.

These bumps appear suddenly and clear promptly when diabetes is well-controlled.

When these bumps appear, they often look like pimples. Unlike pimples, they soon develop a yellowish color. Youll usually find these bumps on the buttocks, thighs, crooks of the elbows, or backs of the knees. They can form anywhere though. No matter where they form, they are usually tender and itchy. The medical name for this skin condition is eruptive xanthomatosis.

Whether this skin condition is associated with diabetes is controversial. We know that most people who have granuloma annulare do not have diabetes. Several studies, however, have found this skin condition in patients who have diabetes. One such study found that people with diabetes were most likely to have granuloma annulare over large areas of skin and that the bumps came and went. Another study concluded that people who have granuloma annulare that comes and goes should be tested for diabetes.

This skin condition causes bumps and patches that may be skin-colored, red, pink, or bluish purple.

If you have diabetes, youre more likely to have dry skin. High blood sugar (glucose) can cause this. If you have a skin infection or poor circulation, these could also contribute to dry, itchy skin.

These develop when you have high fat levels in your blood. It can also be a sign that your diabetes is poorly controlled.The medical name for this condition is xanthelasma.

Many people have skin tagsskin growths that hang from a stalk. While harmless, having numerous skin tags may be a sign that you have too much insulin in your blood or type 2 diabetes.

These growths are most common on the eyelids, neck, armpit, and groin.

Diabetes can cause many other skin problems. Most skin problems are harmless, but even a minor one can become serious in people who have diabetes. A board-certified dermatologist can recognize skin problems due to diabetes and help you manage them.

ImagesImage 1: Image Courtesy of Clark C. Otley, MD. All Rights Reserved

Images 3, 7, 8, 9: Used with permission of the American Academy of Dermatology National Library of Dermatologic Teaching Slides.

Image 2 from DermNetNZ

Some images used with permission of Journal of the American Academy of Dermatology

Images 5, 6 and 10: Getty Images

ReferencesCohen Sabban, EN. Cutaneous manifestations of diabetes mellitus from A to Z. Focus session presented at: 74th Annual Meeting of the American Academy of Dermatology; March 4-8, 2016; Washington D.C.

Duff M, Demidova O, et al. Cutaneous manifestations of diabetes mellitus. Clinical Diabetes. 2015;33:40-8.

Kalus AA, Chien AJ, et al. Diabetes mellitus and other endocrine disorders. In: Wolff K, Goldsmith LA, et al. Fitzpatricks Dermatology in General Medicine (seventh edition). McGraw Hill Medical, New York, 2008:1461-70.

McKinley-Grant L, Warnick M, et al. Cutaneous manifestations of systemic disease. In: Kelly AP and Taylor S. Dermatology for Skin of Color. (first edition). The McGraw-Hill Companies, Inc. China, 2009:481-4.

Morgan AJ and Schwartz RA. Diabetic dermopathy: A subtle sign with grave implications. J Am Acad Dermatol. 2008;58:447-51.

Yosipovitch G, Loh KC, et al. Medical pearl: Scleroderma-like skin changes in patients with diabetes mellitus. J Am Acad Dermatol. 2003;48:109-11.

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Diabetes: 12 warning signs that appear on your skin

Doctor making blood sugar test in clinic. Blood sugar measurement in a medical clinic

Its enough that SARS-CoV-2, the virus that causes Covid-19, can cause pneumonia, kidney failure, blood clots, arrhythmias and even heart attacks, but the potential that the virus may also lead to onset of diabetes provides a new set of implications and potential complications for survivors.

A recent report in Nature details the rationale and proposed mechanisms behind the ability of the virus to damage specialized cells in the pancreas that make insulin, otherwise known as beta cells, contained in surrounding specialized cells (islets).

When beta cells are destroyed, and the body is unable to manufacture insulin, a person develops elevated blood sugar, known as hyperglycemia, which effectively switches the body to an alternate pathway for energy using ketones and ketone bodies as a primary source. Using ketones bodies for energy will trigger a dangerous state where the body produces harmful acids, leading to diabetic ketoacidosis (DKA), which can be fatal if left untreated.

Whats clear is that diabetes is already recognized as a key risk factor for developing severe Covid-19, and persons with this condition have a higher risk of death.

But new research is emerging that the virus not only causes a more severe course in diabetics, but may also trigger onset of the condition in a subset of patients. The potential for a crush of patients with new onset diabetes (Type 1) may be a new reality that the medical community is yet to face.

Clinicians are now seeing previously well people with no history of diabetes who have suddenly developed new onset diabetes after being infected with SARS-CoV-2, along with the dangerous complication, DKA, in which people develop acid in their blood stream, accompanied by rapid breathing, which can lead to shock and death.

If we look back at patients who developed SARS back in 2002-2003, there is a linkage with development of autoimmune conditions such as type 1 diabetes. We also know that many organs which play a role in regulation of blood sugarthe liver, pancreas, kidneys, small intestine and adipose tissue (fat) have a large number of ACE-2 receptors, the receptor on the surface of cells that the virus attaches to using its spike protein. Thats said, the basis for onset of ketosis-prone diabetes following infection with influenza or herpes has been previously reported in the medical literature.

Additional research recently published using miniature lab grown pancreases also suggests that the virus may cause diabetes by injuring the specialized cells, beta cells, that regulate blood sugar.

That said, other researchers have been less convinced about the strength of the connection between Covid-19 and new onset or worsening of diabetes.

We need to keep an eye on diabetes rates in those with prior COVID-19, and determine if rates go up over and above expected levels, said Naveed Sattar, a metabolic-disease researcher at the University of Glasgow, UK in the Nature report.

Clearly, more rigorous studies will be necessary to more definitively establish this link.

That said, a new collaborative research endeavor, the CovDiab Registry, was recently established by a group of researchers to study the presentation and spectrum of illness of patients with newly developed diabetes or complications related to existing diabetes.

The Registry will be useful, the researchers believe, in order to determine not only causes, but whether the diabetic state as a result of Covid-19 is permanent. Another goal will also be to look at those who are pre-diabetic and determine whether Covid-19 accelerates the pathway to Type 2 DM.

In fact, a letter published last month in theNew England Journal of Medicineand signed by an international group of 17 leading diabetes experts involved in the CoviDiab Registry project, announced the establishment of the Global Registry of new cases of diabetes in patients with COVID-19.

Clinical observations thus far demonstrate a bi-directional relationship between Covid-19 and diabetes. On the one hand, diabetes is associated with increased risk of Covid-19 severity and mortality. Between 20 and 30% of patients who died with Covid-19 have been reported to have diabetes. At the same time, new-onset diabetes and life threatening metabolic complications of pre-existing diabetes such as DKA have also been in people with Covid-19.

"Diabetes is one of the most prevalent chronic diseases and we are now realizing the consequences of the inevitable clash between two pandemics, said Francesco Rubino, Professor of Metabolic Surgery at King's College London and co-lead investigator of the CoviDiab Registry project in a press release. Given the short period of human contact with this new coronavirus, the exact mechanism by which the virus influences glucose metabolism is still unclear and we don't know whether the acute manifestation of diabetes in these patients represent classic type 1, type 2 or possibly a new form of diabetes."

One research group at Weill Cornell Medicine in New York City believes that the virus may directly damage the pancreas itself. Using so called organoids, miniature artificial lab- grownorgans, Shuibing Chen and her team demonstrated that the virus can infect beta cells (which make insulin) a portion of which die. The virus seems to also induce production of cytokines which can trigger whats believed to be an inflammatory response that can lead to death of beta cells.

We certainly dont have all the answers just yet. While the organoid study does add some strength to the premise that SARS-CoV-2 may either cause or make existing diabetes worse, this research is still not enough to establish a definitive link, let alone causation.

Its certainly possible that SARS-CoV-2 could produce a heightened inflammatory state which could inhibit the ability of the pancreas to accurately detect glucose and release insulin, while diminishing the capacity and ability of the liver to sense insulin. The end result could potentially lead to diabetes. That said, severe fatigue and muscle atrophy or breakdown could place people at risk for pre-diabetes into a diabetic state.

Long term studies will be essential to better understand the multiple potential mechanisms involved. Stay tuned!

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Can Covid-19 Trigger The Onset Of Diabetes? - Forbes

Study after study has shown that excessive consumption of highly processed carbs and sugar can put a person at risk of developing type 2 diabetes. The trick is finding satisfying substitutes for that soda and white bread. We suggest the following.

Replacing Sugar In Your Diet

A discussion regardingweight loss or a healthier body normally prompts a discussion on how to reduce sugar consumption.Even eatingfruits and vegetables has prompted healthy exchanges among experts.

As such, here are reasonsto cut back on sugar, and substitutes for it:

Replace sugar with natural sources

Despite the controversy over whether natural sugar is any less harmful than the processed kind, the least complicatedway to cut back on sugar is byreplacing it with a natural alternative. Jaggery, for example, can be added to both tea and coffee.

Opt for detox water over sodas

A 2010 Diabetes Care study found that those who drank sugar-laden drinks, 1 to 2 servings a day, had a 26 percent greater chance of developing diabetes than those who drank one serving or less a month. Drink detox water instead, which is made by infusing water with crushed fruits and vegetables for some added flavor.

Bag the can

Canned fruits usually contain syrup, which also has sugar. Instead, buy fresh fruitsfor a healthier alternative.

Hide the sugar bowl

Dont want sugar? Then remove it from the dining table. Out of sight, out of ....

Munch on whole foods

A 2007 Archives of Internal Medicine study conducted among Chinese women found that those who ate foods containing highly processed carbohydrates had a 21 percent greater chance of developing type 2 diabetes than those in the group who ate whole foods.Additionally, theyalso keep you feeling satedfor longer, helping you avoid munching on those snacks sitting on top of your trefrigerator.

Both white and brown sugar came from either the sugarcane or sugar beet plant but they have different properties. Pixabay

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Carbs, Sugar and Threat of Diabetes: Reduce Consumption, Reduce Type 2 Risk - Medical Daily

Hyperglycemia occurs when a person with diabetes has too much sugar in their bloodstream. The underlying cause of hyperglycemia is due to a loss of insulin producing cells in the pancreas or when the body develops resistance to insulin. The condition can become dangerous when blood glucose levels stay high for extended periods of time which could lead to the development of long-term complications. Eating the right kinds of food to help stabilise blood sugar levels is well known but what about certain drinks.

Diabetes insipidus is a rare form of diabetes that is not related to blood sugar-related diabetes mellitus but does share some of its signs and symptoms saidDiabetes.co.uk.

The websitecontinued: Diabetes insipidus is simply excessive urination and complications thereof, caused by an antidiuretic hormone called vasopressin.

Diabetes insipidus leads to frequent urination, and this is the most common and clear symptom.

A secondary symptom is increased thirst, as a result of passing so much water and if this is not met, then dehydration can occur which can lead to cracked skin, fatigue, confusion, dizziness and unconsciousness.

There are a variety of factors which contribute to the onset of type 2 diabetes but one of the most common is consuming a large amount of calories throughout the day, especially from added sugars which are found in many foods and, notably, in beverages.

Diabetics are strongly advised to monitor their calorie intake which is often overlooked by the drinks consumed.

Diabetics are recommended to minimise their calories and opting for pure, plain water which contains zero calories is always the best option.

Water does not raise a persons blood sugar levels and studies have shown that when a diabetic has too high a blood glucose level, drinking water enables more glucose to be flushed out of the bloodstream.

Experts agree that water should be the main source of hydration for type 2 diabetes.

If youre consistently dehydrated on a daily basis, you might even be compensating with higher insulin levels than youd need if your body was getting the water it needed, said Diabetes Strong.

The health site added: Its the simple issue of severe dehydration causing the glucose in your bloodstream to become extremely concentrated, and then quickly diluting it with plenty of fluids.

Water actually does far more for our bodies than we realise.

Water aids digestion, lubricates joints, helps flush waste products and performs a host of other important tasks in our body.

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Type 2 diabetes: The best drink to consume to help lower blood sugar - Express