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Baylor Genetics and Rice University form partnership to create a first-of-its-kind solution for the university to resume in-person classes for the fall semester despite the COVID-19 pandemic

HOUSTON, Aug. 13, 2020 /PRNewswire/ --Baylor Genetics, a clinical diagnostics laboratory known for genetic testing and precision medicine, and Rice University, a private, comprehensive research university located in Houston, Texas, have partnered together to create a first-of-its-kind, total turnkey solution for the university to resume in-person classes for the fall semester despite the COVID-19 pandemic.

"For Baylor Genetics and Rice University, this partnership represents a moon-shot opportunity to benefit students, faculty, and staff," stated Kengo Takishima, President and Chief Executive Officer at Baylor Genetics. "It is imperative families have peace of mind as they send their children to college and we've set an aggressive goal of serving as a blueprint for other academic institutionsand, more broadly, society."

Many universities nationwide have been strongly impacted by the pandemic and have announced changes to the fall semester. One of the major changes is universities going fully online for the semester. Fortunately, Rice has been able to overcome many challenges brought on by COVID-19 thanks to its partnership with Baylor Genetics.

"In terms of learning online, I found that it wasn't that intuitive and effective for my own learning style. In addition to that, it is my senior year and I wanted to get one last taste of the community that I have come to grow and love here," said Victor Nguyen, a senior at Rice University, in an interviewreleased by the university. "Being on campus again feels a little bit more of what we are used to, even though we live in a new reality. It's closer to normal so it's exactly what we were hoping for."

This partnership entails Baylor Genetics providing support for temperature checks, on-campus sample collection and transport logistics, processing of samples, and customized results reporting for individuals via email. Nearly 60,000 screening tests will be performed by Baylor Genetics with a turnaround time of 48 hours or less.

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In addition to large-scale surveillance testing, the partnership includes population management reporting. This custom reporting system delivers population data to assist policymakers at Rice with managing the campus community and by aiding in intelligent decision making.

"Testing by itself is not enough," said Kevin Kirby, Rice University's Vice President for Administration."What matters is how we use that information to act quickly to isolate, treat, contact trace, and quarantine those affected. A systematic approach is the best practice for creating an environment that will mitigate the spread of COVID-19."

In addition, data tracking will provide the university with specific trends and infection rates on buildings, facilities, and housing throughout the campus. This innovative approach is part of Rice's strategy to prevent cross-contamination and ensure the safety of its faculty, students, and staff. There are plans to extend the partnership with symptomatic testing in the near future.

"This opportunity is a chance to demonstrate that we can operate safely in such a difficult time," said Chad Shaw, Ph.D., Sr. Director of the Baylor Genetics Innovation Lab, Adjunct Professor of Statistics at Rice University, and Professor in the Department of Molecular and Human Genetics at Baylor College of Medicine, "As a Houstonian and a member of both the Baylor and Rice faculty, I am excited by the opportunity to serve my community to find a thoughtful and creative way to overcome the COVID challenge. It takes commitment, grit, and a team effort."

The program began the week of Aug. 3 with college staff, graduate students, and orientation coordinators. For students, testing is broken down into three phases and will begin Aug. 15. There will be no charge to faculty, studentsor staff for the on-campus testing.

For members of the Rice community that are confirmed positive for the coronavirus (SARS-CoV-2), Rice will follow the Centers for Disease Control and Prevention contact-tracing protocols to identify others who have had significant contact with those tested positive.

Baylor Genetics' test for COVID-19 has one of the highest sensitivity (true positive rate) and specificity (true negative rate) rates for identifying active coronavirus infection. All precautions, policies, and guidelines have been put in place with one goal in mind continue education in the safest, most effective way possible.

Media Contact:Jamie LimEmail: pr@baylorgenetics.com

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Baylor Genetics and Rice University Form COVID-19 Screening Partnership for the Fall Semester; Partnership Aims for 'Moon-Shot' 48-Hours-or-Less...

Image: Breast cancer cell. Credit: Anne Weston, Francis Crick Institute.

UK scientists have discovered three new genetic changes that increase the risk of breast cancer in men, in the worlds largest genetic study of the causes of male breast cancer to date.

Researchers, largely funded by Breast Cancer Now, identified three common variations in DNA that predispose men to developing breast cancer, bringing the total known number to five.

All three genetic variants are known to be linked to female breast cancer but scientists at The Institute of Cancer Research, London, and Queens University Belfast found the changes to have a greater effect on breast cancer risk in men than in women.

The study involved 1,380 men with breast cancer, primarily from the Breast Cancer Now Male Breast Cancer Study based at The Institute of Cancer Research (ICR). The team found that three genetic changes, called rs9371545, rs554219 and rs78540526, increased the risk of developing breast cancer in men by approximately 47, 45 and 61 per cent respectively.

The researchers then analysed over 170 SNPs known to affect risk in women, finding significant overlap in the genetic risk factors for the disease in men. The results suggest male and female breast cancer may have a very similar genetic basis a discovery which could in future lead to new preventive treatments for men and women.

The study also found that men at the highest genetic risk were almost four times more likely to develop breast cancer than those at lowest risk.

Breast Cancer Now described the discovery as a major step forward in our understanding of male breast cancer, calling for greater awareness of the disease in men and for research into the shared genetic causes of male breast cancer and the most common form in women (ER+), to develop risk-reducing drugs and other interventions to prevent more cases among those at increased risk.

The study was funded by Breast Cancer Now and Queens University Belfast, and is published in the Journal of the National Cancer Institute.

While breast cancer in men is very rare, around 370 men are diagnosed with the disease every year in the UK, and around 80 men lose their lives each year.

There are a number of different treatments for breast cancer in men depending on the features of the tumour, including surgery, hormone therapy, radiotherapy, chemotherapy and targeted drugs all of which were first developed to treat the disease in women.

More than 95 per cent of all breast cancers in men are oestrogen receptor (ER) positive compared to up to 80 per cent of cases in women meaning that they contain proteins called oestrogen receptors and can be stimulated to grow by the hormone.

Men with a strong family history of breast cancer among female relatives are known to be at greater risk, and around 10 per cent of male cases are caused by mutations in the BRCA2 gene. But the exact causes of the disease in men are not yet understood, and, for years, there has been considerable debate about whether male and female breast cancer are distinct from one another.

While mutations in genes such as BRCA2 can increase the risk of breast cancer by a great deal, these faults are relatively rare and major research has shown that single-letter changes to our DNA code (called Single Nucleotide Polymorphisms or SNPs) also influence cancer risk.

With up to 15 million places where SNPs can exist across our genome, these changes are relatively common.

In a major new genetic analysis pooling data from multiple studies worldwide, researchers led by Dr Nick Orr at the Breast Cancer Now Research Centre at The Institute of Cancer Research (ICR) and at Queens University Belfast compared the genomes of 1,380 men with breast cancer to 3,620 men without.

The scientists discovered three new SNPs that were significantly associated with an increased risk of breast cancer in men: one on chromosome 6 (rs9371545) and two on chromosome 11 (rs554219 and rs78540526).

The researchers then investigated the extent of the shared genetic causes of the disease in men and women by evaluating 172 regions in the genome linked to female breast cancer, for an association with male breast cancer.

The team found a strong correlation between the genetic risk factors of male and female breast cancer, with 20 per cent of SNPs that influence (increase or decrease) the risk of breast cancer in women also having an effect on male breast cancer risk.

The study also observed some important differences, with some SNPs carrying a greater increase in risk for women than for men or vice versa, and some SNPs also changing the risk in opposite directions for men than for women.

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Having identified this overlap, the researchers then investigated how well a DNA test (313 SNP risk score), which was designed to estimate breast cancer risk in women, worked for men.

They found there was nearly a four-fold increase in risk between men in the highest genetic risk category and those in the lowest (OR= 3.86), and that the distribution of cases across risk categories was similar to that observed in women.

The findings add to the major discovery in 2012 from the Breast Cancer Now Male Breast Cancer Studyby the same authors, that a single change in the genetic code of a gene called RAD51B can increase the risk of breast cancer in men by up to 50 per cent.

It is hoped that the discovery of new locations in the genome linked to male breast cancer could now enable scientists to identify the biological mechanisms that cause the disease to develop in men, and could ultimately lead to the development of new preventive drugs for those at high risk.

While further research would be needed, the authors also suggest the findings could in future help to develop more precise risk testing for men carrying BRCA2 mutations, enabling them to understand whether they are at additional or lower risk due to other genetic changes, which could help guide decisions around any risk-reducing steps.

Lead author Dr Nick Orr, who led the research at the ICR, and the Patrick G. Johnston Centre for Cancer Research at Queens University Belfast, said:

There has been much debate about whether breast cancers in women and men are distinct from one another. Our study has shown, for the first time, that the genetic factors influencing susceptibility to male breast cancer and the most common type of female breast cancer are much more alike than they are different.

Our findings suggest that the underlying biology that affects how breast cancer develops and grows are probably similar in men and women. This means that advances in prevention and treatment for the disease may be of benefit to all patients, irrespective of their gender.

Dr Simon Vincent, Director of Research, Services and Influencing at Breast Cancer Now, which funded the study, said:

This study, which shows more of a similarity between the genetic causes of the disease in men and women than previously thought, is a major step forward. Our knowledge of breast cancer in men is limited, because male breast cancer is rare which makes it difficult to collect enough tissue or blood samples to research and understand the disease. Research like this is critical to improving our understanding of the disease in men and we hope the Breast Cancer Now Male Breast Cancer Study will continue advancing our knowledge.

We now look forward to further research into the shared genetic causes of male breast cancer which could lead to developing risk reducing treatments and interventions to help prevent more cases among those at increased risk in the future.

The Breast Cancer Now Male Breast Cancer Study is the largest collection of DNA and tumour samples from men with breast cancer in the world, with over 1,000 men who have been diagnosed participating, as well as over 1,000 men without breast cancer. Based at the ICR, the study was established in 2008 to pinpoint the genetic, environmental and lifestyle causes of breast cancer in men.

Jo Tridgells husband John died in January 2017 after being diagnosed with breast cancer in November 2015. John took part in several research projects, including the National Male Breast Cancer Study led by the ICR. Commenting on the new research, Jo said:

When my husband John was going through treatment, it was always a question mark for me whether breast cancer in men warranted different drugs than that in women. This new study shows that the disease is genetically similar irrespective of your sex, so that feels like a real breakthrough knowing that treatment courses could be the same. Any research that helps us to understand how breast cancer risk can be monitored and the disease prevented in future is of vital importance to families like ours.

Read more here:
Scientists discover three new genetic variants linked to male breast cancer - The Institute of Cancer Research

LONDON--(BUSINESS WIRE)--Technavio has been monitoring the animal genetics market and it is poised to grow by USD 1.79 billion during 2020-2024, progressing at a CAGR of 7% during the forecast period. The report offers an up-to-date analysis regarding the current market scenario, latest trends and drivers, and the overall market environment.

Technavio suggests three forecast scenarios (optimistic, probable, and pessimistic) considering the impact of COVID-19. Please Request Free Sample Report on COVID-19 Impact

Frequently Asked Questions-

The market is concentrated, and the degree of concentration will accelerate during the forecast period. Animal Genetics Inc., AquaGen AS, Aviagen Group, Coperatie Koninklijke CRV u.a., Genetic Veterinary Sciences Inc., Genus Plc, Hendrix Genetics BV, Neogen Corp., Topigs Norsvin, and Zoetis Inc. are some of the major market participants. To make most of the opportunities, market vendors should focus more on the growth prospects in the fast-growing segments, while maintaining their positions in the slow-growing segments.

Animal Genetics Market 2020-2024: Segmentation

Animal Genetics Market is segmented as below:

To learn more about the global trends impacting the future of market research, download a free sample: https://www.technavio.com/talk-to-us?report=IRTNTR40040

Animal Genetics Market 2020-2024: Scope

Technavio presents a detailed picture of the market by the way of study, synthesis, and summation of data from multiple sources. Our animal genetics market report covers the following areas:

This study identifies the increase in consumption of animal-derived food products as one of the prime reasons driving the animal genetics market growth during the next few years.

Animal Genetics Market 2020-2024: Vendor Analysis

We provide a detailed analysis of vendors operating in the animal genetics market, including some of the vendors such as Animal Genetics Inc., AquaGen AS, Aviagen Group, Coperatie Koninklijke CRV u.a., Genetic Veterinary Sciences Inc., Genus Plc, Hendrix Genetics BV, Neogen Corp., Topigs Norsvin, and Zoetis Inc. Backed with competitive intelligence and benchmarking, our research reports on the animal genetics market are designed to provide entry support, customer profile and M&As as well as go-to-market strategy support.

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Animal Genetics Market 2020-2024: Key Highlights

Table of Contents:

PART 01: EXECUTIVE SUMMARY

PART 02: SCOPE OF THE REPORT

PART 03: MARKET LANDSCAPE

PART 04: MARKET SIZING

PART 05: FIVE FORCES ANALYSIS

PART 06: MARKET SEGMENTATION BY SOLUTION

PART 07: CUSTOMER LANDSCAPE

PART 08: GEOGRAPHIC LANDSCAPE

PART 09: DECISION FRAMEWORK

PART 10: DRIVERS AND CHALLENGES

PART 11: MARKET TRENDS

PART 12: VENDOR LANDSCAPE

PART 13: VENDOR ANALYSIS

PART 14: APPENDIX

PART 15: EXPLORE TECHNAVIO

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Technavio is a leading global technology research and advisory company. Their research and analysis focuses on emerging market trends and provides actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions. With over 500 specialized analysts, Technavios report library consists of more than 17,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavios comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios.

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Insights on the Global Animal Genetics Market 2020-2024 | COVID-19 Analysis, Drivers, Restraints, Opportunities and Threats | Technavio - Business...

Findings and methods developed can be used to screen large populations and high-risk individuals at a cost less than Rs 5000, according to the release

Findings of the first-ever research capturing the polygenic risk score for South Asia populations for coronary artery disease were recently published in the Journal of the American College of Cardiology (JACC).

Conducted by MedGenome Labs, in collaboration with researchers from Broad Institute of MIT and Harvard; Massachusetts General Hospital, Boston; Narayana Health, Bangalore; Eternal Hospital, Jaipur; Madras Medical Mission, Chennai; KMCH, Coimbatore and a few other institutes, the study on Indian population validates a novel CAD-PRS (coronary artery disease-genome-wide polygenic risk score) to precisely predict the risk of developing a coronary artery disease/myocardial infarction (MI) using a persons genetic makeup.

Knowing the polygenic risk is important to individuals with a family history of CAD, hypertension, diabetes, high cholesterol level, smoking habits, alcohol consumption, stressful lifestyle, as CAD results from a combination of these factors. A poor lifestyle and high polygenic risk could be a fatal combination and may result in early-onset CAD.

Such findings and methods developed can be used to screen large populations and high-risk individuals at a cost less than Rs 5000.

Looking at all the available scientific evidence and our study results we are convinced that there exists a good opportunity to combine both clinical and genetic risks (polygenicrisk score based) and significantly improve the primary prevention of coronary artery disease (CAD). We firmly believe that incorporatingvalidated genetic risk scores would help in better stratification of high-risk individuals if implemented at population level,said Dr Vedam Ramprasad, CEO, MedGenome Labs.

This unique study is based on the principle of Genome-wide Polygenic Risk Score (PRS) which usesa genome-wideanalysis of an individual to quantify the risk of developing heart disease.

It was conducted on the south Asian population in 1800 confirmed CAD cases and 1163 control samples from five centres across the country with a median age between 54 and 55 years. The findings of this study have helped develop a CAD PRS that integrates information from millions of sites of common DNA variation into a single metric that can be calculated from birth and validate a scalable polygenic score framework in India. This finding lays the scientific and operational foundation for clinical implementation not just for CAD but for other diseases.

CAD PRS is a powerful genetic predictor that can be used to identify individuals at increased risk for CAD. It provides a quantified risk score based on ones genetic makeup and predicts a patients risk for having an acute coronary event, such as a heart attack, before symptoms appear. CAD PRS is an important new risk factor to help physicians stratify high-risk patients and better guide treatment decisions and lifestyle interventions, said Dr Sekar Kathiresan, CEO, Verve Therapeutics and Professor of Medicine, Harvard Medical School, Cardiology Division, Massachusetts General Hospital.

According to a research paper published in theJournal of Genetics, the estimated prevalence of CAD disease in India is about 10.5 per cent of the population which extrapolates to a burden of about 32 million affected individuals. Over and above, the incidence of cardiac disorders has increased from 2 per cent to 10.5 per cent of the urban population in the past few years and early age of onset is a new countrywide trend.

South Asians no matter where they stay in India or any other country always have higher cases of CAD than Caucasians. Even if our body structure is much leaner, smaller and thus comparatively lower food consumed compared to Caucasians, we still end up with CAD. So, it can be considered that South Asians have some genetic issue that is causing high CAD cases and hence we need to identify these genetic factors so that we are able to manage the disease in our population, said Dr Ajit Mullasari, Director, Adult Cardiology, Madras Medical Mission.

The virtual press conference and announcement was also supported by several eminent cardiologists from across the country Dr Ramesh Seshadri, Dr Julius Punnen, Dr Varun Shetty, Dr Bagirath Raghuraman from Narayana Institute of Cardiac Science, Bangalore, Dr.Pradeep Narayan, RTIIS, Kolkata, Dr Rajendra N.S, Narayana Hospital, Mysore and Dr Rajeev Gupta, EHCC Jaipur.

Excerpt from:
Experts develop genetic risk score to predict heart disease in South Asia - Express Healthcare

The study is the first comprehensive attempt to determine the genetic relatedness of the Gujjars and Ladakhis to populations within India and elsewhere in the world

The Union Territories of Jammu and Kashmir (J&K) and Ladakh in North India, withtheir wide variety of landscape,are a congruence of several languages and cultural practices. The region is believed to have served as a corridor for ancient human migrations between the Indian subcontinent and North-East Asia, Eurasia and Africa.

The populations in the region offer a unique opportunity to investigate the past anthropological and demographic events which might have shaped the extant human population diversity. In a new study, scientists at the Department of Biotechnologys Centre for DNA Fingerprinting and Diagnostics (DBT-CDFD) have sought to decipher the genetic diversity encompassed by Gujjars from the Jammu region of J&K and the Ladakhi populations.

A previous study had found that the two communities Gujjars and Ladakhis exhibited lower genetic affinity towards other populations in their geographical proximity. To better understand the genetic diversity in these populations, a battery of DNA markers located on autosomes, Y-chromosome and the mitochondrial genome were employed.

The principal coordinate and cluster analysis based on autosomal DNA markers indicated Gujjars and Ladakhis were genetically distant to each other as well as to other reference populations of India, which was in concordance with Y-chromosomal analysis.

The genetic affinity of Gujjars in the Jammu region to Pashtuns in the Baghlans and Kunduz provinces of Afghanistan and Pashtuns and Sindhis in Pakistan indicated their past genetic relatedness and a common ancestry. On the other hand, Ladakhis were found to be genetically close to Chinese (Uighurs and Han) and Nepalese (Magar) populations, which might be due to their close geographic proximity.

Y-haplogroup (which represent a group of individuals who have inherited a common set of markers)-based studies suggested that the Gujjars are less diverse as compared to Ladakhis. The presence of many rare haplogroups in Ladakhis portrays rich accumulation of male-mediated contribution in the past.

The mitochondrial DNA analysis supported the findings that the Gujjars are less genetically diverse as compared to Ladakhis, which perhaps may be due to the endogamous cultural practices in this group (where they marry within a specific community or caste or group). The Y-chromosomal and mitochondrial analysis showed higher genetic differentiation among males than females indicating patrilocality among these populations.

The present study is the first comprehensive attempt to determine the genetic relatedness of the Gujjars and Ladakhis to populations within India and elsewhere in the world and would help in gaining deeper insights into genetic diversity and demographic settlement in this part of the world.

The researchers, Mugdha Singh, Anujit Sarkar, Devinder Kumar and Madhusudan R Nandineni, have published a paper in Scientific Reports titled `The genetic affinities of Gujjar and Ladakhi populations of India. (India Science Wire)

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New study sheds light on genetic affinities of Gujjars and Ladakhis - Down To Earth Magazine

Newswise The protein Connexin 26 has been previously identified as being directly sensitive to Carbon dioxide and linked to conditions such as KIDS syndrome and deafness.

Thanks to a 686,956grant from the BBSRC, researchers from the School of Life Sciences at the University of Warwick will investigate the role of Connexin 26 (Cx26) in the control of breathing

They will highlight whether carriers of certain mutations of Cx26 are more likely to suffer from a reduced respiratory drive, and ability to regulate breathing

The relationship between the Cx26 gene and ability to regulate Carbon dioxide is to be explored by researchers from the School of Life Sciences, at the University of Warwick, thanks to a 686,956grant, from the BBSRC.

Professor Nicholas Dale, from the School of Life Sciences at the University of Warwick has previously identified that the protein Connexin 26 (Cx26) is directly sensitive to Carbon Dioxide (CO2).

Cx26 protein can have different mutations, which have previously been linked with KIDS syndrome, and deafness, this shows that both types of mutation can cause Cx26 to lose sensitivity to CO2.

Thanks to a 686,956grant from the BBSRC, researchers from the School of Life Sciences at the University of Warwick hope that their project, New tools for investigating connexin26 hemichannel function in physiological systems, may be able to directly identify a link between how Cx26 responds to CO2and its ability to control breathing. In the long term this could lead to understanding of how gene mutations interfere with this, and could help to develop new tests and treatments for breathing problems such as sleep apnoea.

Cx26 can respond to CO2in two different ways. This research aims to allow researchers to pin down which one of these two ways is involved in the control of breathing. To do this they will exploit how the Cx26 gene evolved from fish to man. Using the sequenced genome of Lungfish, researchers have previously researched Cx26 in the lungfish, which is closely related to the first existing species that crawled from water onto land and are air breathing. When studying the lungfish Cx26 protein researchers found that the lungfish Cx26 had only one way of responding to CO2, because the protein is slightly different, and has a long extension of 24 amino acids on one end of it.

Researchers plan to exploit this extension as a genetic tool, and hope that adding the extension of amino acids from lungfish Cx26 to human Cx26 will result in a subunit that can co-assemble with the native protein to remove one form of signalling. If this can be proven, researchers can look at breathing and see the extent to which one form of signalling contributes to breathing. If established it will lead to ways of treating the defects in the Cx26 molecule in humans carrying Cx26 mutations.

Professor Nicholas Dale, from the School of Life Sciences at the University of Warwick comments:

We hope that by the end of this four year project we can definitively establish how Cx26 controls breathing, and give new insight into how mutations of this key molecule could lead to altered control of breathing in humans.

If all goes well, in the long term it could provide new ways to diagnose breathing problems such as sleep apnoea, and introduce new clinical management strategies for Cx26 patients with mutations that affect CO2sensitivity to improve their quality of life.

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Genetic mutation may hold answers to controlled breathing - Newswise

GREENVILLE, S.C.--(BUSINESS WIRE)--Premier Medical Laboratory Services (PMLS) announces today that they have been named one of the Top Genetic Diagnostic Companies of 2020 by Healthcare Tech Outlook, a leading national healthcare publication. The designation, earned by the Greenville, SC laboratory, comes with recognition for their providing the most advanced diagnostic testing solutions with accuracy and efficiency through employing the latest in science and technology.

One of the reasons PMLS was selected by the publication is that they are a highly complex laboratory with various types of test offerings to address many medical diagnostic needs. From COVID-19 PCR tests, antibody testing, pharmacogenomics, advanced cardiovascular testing, and their womens health & wellness and diabetes panels, all of PMLS tests are performed under one roof with cutting-edge laboratory equipment, providing a quick turnaround of results for physicians and patients.

We are honored to be designated as a top genetic diagnostic company of 2020 by Healthcare Tech Outlook, said Kevin Murdock, Founder of Premier Medical Laboratory Services. Our team of scientists and laboratory personnel is continually focused on providing the most advanced solutions to diagnostic testing demands, and to helping physicians provide top-level care to their patients.

Along with titling PMLS a top genetic diagnostic company, Healthcare Tech Outlook noted that Premier Medical Laboratory Services MDDiabeticPro panel includes the revolutionary DIABETESpredict test, which is a first of its kind predictive genetic test for type 2 diabetes developed in collaboration with world leading doctors and scientists of Harvard and MIT. The DIABETESpredict test is expected to mark a new era in diabetes prevention and care through evaluating the risk of the disease onset by examining individual genetic profiles and is currently available to the US through PMLS.

Along with their MDDiabeticPro panel, the article also recognizes PMLS full respiratory pathogen panel and GI panel, as well as their cardiovascular panel MDHeartPro, which more accurately depicts a patients overall heart health than a standard lipid panel that is often used by other laboratories. All of these testing services are conducted at PMLSs 40,000 sqft COLA and CLIA regulated laboratory in Greenville, South Carolina alongside their recently added portfolio of COVID-19 related tests.

By employing the latest in laboratory equipment, added staff and a highly advanced laboratory information management system, OnGen, PMLS has been able to expand their testing capacity and add quality PCR and antibody testing for COVID-19 to their diagnostic testing services. Additionally, the article explores how PMLS has found solutions to overcome COVID-19 supply chain shortages in coordination with their sister company, CPT Medical, who makes their own viral transport media and specimen collection kits.

Healthcare Tech Outlook states, PMLS is a highly sophisticated and top of the line advanced diagnostics lab with robust diagnostic services.

To read the full article, please visit this link: https://bit.ly/2POMkYW.

For more information about Premier Medical Laboratory Services, please visit http://www.PreMedInc.com or call 1.877.335.2455.

ABOUT PREMIER MEDICAL LABORATORY

Premier Medical Laboratory Services (PMLS) is a CLIA and COLA regulated laboratory based in Greenville, South Carolina focused on providing clinically meaningful results to medical practitioners. Premier Medical Laboratory Services offers a variety of highly specialized tests including: the only Type II Diabetes molecular predisposition test available in the U.S., advanced cardiovascular testing, hereditary cancer screening, carrier screening, womens health panels, pharmacogenomics, serum allergy testing, blood wellness, Hepatitis C genotyping, respiratory pathogens, gastrointestinal pathogens, and more. In addition to its specialty programs, Premier Medical Laboratory offers a comprehensive testing menu of general chemistry, immunoassay, and hematology tests. The company also is proud to offer a patient friendly billing policy.

For more information, please visit http://www.PreMedInc.com or call 1.877.335.2455.

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Premier Medical Laboratory Services Named Among Top Genetic Diagnostic Companies of 2020 by Healthcare Tech Outlook - Business Wire

Inherited mutations in a gene that keeps nerve cells intact was shown, for the first time, to be a driver of a neuropathy known as Charcot-Marie-Tooth (CMT) disease. This finding is detailed in a study led by researchers in the Perelman School of Medicine, which published inNeurologyGenetics, an official journal of the American Academy of Neurology.

The findings, thanks to siblings treated at Penn since the late 1980s, present a clearer picture of the diseases genetic underpinnings that could inform the development of gene therapies to correct it.

The mutations in the gene known as dystonin (DST) add to a growing list of malfunctions found to cause their type of CMT, known as CMT2, which is defined by the loss of the nerve fibers, or axons, in the peripheral nerve cells. The researchers also showed that these mutations affect two key protein isoforms, BPAG1-a2 and BPAG1-b2, that are involved in nerve fiber function. Mutations in other isoforms of the same protein were previously tied to a blistering skin disease.

There are more than 100 mutations found to be associated with CMT, with likely many more out there.Past studies from Penn researchers haveidentified some of these mutations by studying patients treated at Penn Medicine.

We are determined to fill in the blanks of this giant jigsaw puzzle, says senior authorSteven S. Scherer, a professor of neurology. This latest paper is but one of many examples of where breakthroughs have happened between patients and the doctors at Penn and the support of different organizations and institutions to bring it all together."

Read more at Penn Medicine News.

Continued here:
New genetic cause of an inherited neuropathy discovered | Penn Today - Penn Today

This article was originally published here

Oncol Lett. 2020 Sep;20(3):2829-2839. doi: 10.3892/ol.2020.11843. Epub 2020 Jul 9.

ABSTRACT

The present study aimed to elucidate the genetic features of multiple lung cancer (MLC) and identify effective molecular markers for diagnosis using next generation sequencing (NGS). The present data may also inform patient treatment and prognosis. A total of 35 lesions were obtained from 17 patients with MLC. Based on lesion histology and NGS, 13 cases of multiple primary lung cancer (MPLC) were identified and 4 cases were classified as intrapulmonary metastasis (IPM). All 4 patients with IPM exhibited an epidermal growth factor receptor (EGFR) mutation and synchronous mutation of at least one tumor suppressor gene. The frequency and percentage of EGFR mutations, accompanied with tumor suppressor genes, were significantly higher in patients with IPM compared with MPLC. Furthermore, a high EGFR-heterogeneity score and male sex were risk factors of IPM occurrence. There were significant differences in mean EGFR mutation abundance alone, mutations of tumor suppressor genes and mutations of EGFR combined with tumor suppressor genes between patients with adenocarcinoma (ADC) and adenocarcinoma in situ (AIS). In conclusion, histological characteristics combined with genetic alterations may be an effective method for the diagnosis of MPLC and IPM, and NGS may serve as a useful diagnostic tool. MLC exhibited unique molecular characteristics, including higher rates of EGFR mutations, EGFR driver mutations accompanied with tumor suppressor gene mutations and the absence of anaplastic lymphoma kinase mutations, which may help distinguish between patients with MPLC or IPM. The present study hypothesized that the mean frequency of EGFR mutations, mutations of tumor suppressor genes and mutations of both EGFR and tumor suppressor genes may serve an important role in the development of AIS to ADC. The results of the present study highlight the potential underlying mechanisms of lung ADC development, which may assist with future elucidation of effective treatments to prevent the progression of lung cancer.

PMID:32782601 | PMC:PMC7400153 | DOI:10.3892/ol.2020.11843

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Genetic features and application value of next generation sequencing in the diagnosis of synchronous multifocal lung adenocarcinoma - DocWire News

Bengaluru: MedGenome Lab has conducted a first-ever study on Indian population that validates a novel CAD-PRS (coronary artery disease-genome-wide polygenic risk score) to precisely predict the risk of developing a coronary artery disease/myocardial infarction (MI) using a persons genetic makeup.

MedGenome collaborated with researchers from Broad Institute of MIT and Harvard; Massachusetts General Hospital, Boston; Narayana Health, Bangalore; Eternal Hospital, Jaipur; Madras Medical Mission, Chennai; KMCH, Coimbatore and a few other institutes to conduct this first-ever research capturing the PRS of disease for South Asia populations and its findings are now published in the Journal of the American College of Cardiology (JACC).

Dr. Vedam Ramprasad, CEO, MedGenome Labs said Looking at all the available scientific evidence and our study results we are convinced that there exists a good opportunity to combine both clinical and genetic risks (polygenic risk score based) and significantly improve the primary prevention of coronary artery disease (CAD)."

The unique study is based on the principle of Genome-wide Polygenic Risk Score (PRS) which uses a genome-wide analysis of an individual to quantify the risk of developing heart disease.

It was conducted on the south Asian population in 1800 confirmed CAD cases and 1163 control samples from five centres across the country with a median age between 54 and 55 years.

The findings of this study have helped develop a CAD PRS that integrates information from millions of sites of common DNA variation into a single metric that can be calculated from birth and validate a scalable polygenic score framework in India.

This finding lays the scientific and operational foundation for clinical implementation not just for CAD but for other diseases. Such findings and methods developed can be used to screen large populations and high-risk individuals at a cost less than 5000 INR.

Knowingly, the polygenic risk is important to individuals with a family history of CAD, hypertension, diabetes, high cholesterol level, smoking habits, alcohol consumption, stressful lifestyle, as CAD results from a combination of these factors. A poor lifestyle and high polygenic risk could be a fatal combination and may result in early-onset CAD.

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Experts develop a breakthrough genetic risk score for Heart Disease in South Asia - ETHealthworld.com

This article was originally published here

Breast Cancer Res Treat. 2020 Aug 9. doi: 10.1007/s10549-020-05859-0. Online ahead of print.

ABSTRACT

PURPOSE: To define the prevalence and risk factors of anxiety and examine rates and predictors of psychotherapy and integrative medicine service use in breast cancer survivors on aromatase inhibitors (AIs).

METHODS: Observational study of patients with histologically confirmed stage 0-III hormone receptor-positive breast cancer taking a third-generation AI at the time of enrollment. Patients completed self-report measures of anxiety and utilization of psychotherapy and integrative medicine services at a single time-point. We used multivariate logistic regression analyses to identify factors associated with anxiety and receipt of anxiety treatment services.

RESULTS: Among the 1085 participants, the majority were younger than 65 years of age (n = 673, 62.0%) and white (n = 899, 82.9%). Approximately one-third (30.8%) reported elevated anxiety ( 8 on the anxiety subscale of the Hospital Anxiety and Depression Scale). Of patients with elevated anxiety, only 24.6% reported receiving psychological counseling, 25.3% used integrative medicine services, and 39.8% received either type of treatment since their diagnosis. Patients with an education level of high school or less were less likely to receive psychological counseling (AOR, 0.43, 95% CI 0.19-0.95) and integrative medicine services (OR 0.30, 95% CI 0.12-0.72) than patients with higher levels of education.

CONCLUSIONS: Anxiety is common in breast cancer patients treated with AIs yet the majority of anxious patients do not receive evidence-based treatment, even when these treatments are available. Better systematic anxiety screening and treatment initiation are needed to reduce disparities in care by education level.

PMID:32772224 | DOI:10.1007/s10549-020-05859-0

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Receipt of psychological counseling and integrative medicine services among breast cancer survivors with anxiety - DocWire News

One of the many untold effects of the COVID-19 pandemic is the toll it is taking on patients without COVID. During the initial wave of COVID cases, staying home was universally urged to protect people from exposure to the infection, but, in the process, many people ignored serious medical issues that should have sent them to their provider or an emergency room. One survey found that almost one-third of people admitted to delaying or avoiding emergency care even though they needed it. While access and affordability continue to be a huge problem in healthcare, many today are wondering if it is safe to see the doctor for routine visits yet.

Join Kris Kington Barker as she hosts the program from homeamid concerns about the spread of theCOVID-19 virus. She will be speaking with Susan Polk, owner of Susan Polk InsuranceAgency and Lindsey Faucette,DO, FAAFP, Chief Medical Officer at SLO Health-Family and Integrative Medicine as they discuss how COVID-19 is impacting healthcare access, utilization and insurance coverage for non COVID care.

You are invited to listen, learn and participate in the conversationtoday, Thursday, between 1-2 pm. Call in and be part of the discussion at(805) 549-8855 or email questions to voices@kcbx.org.

Broadcast date: 8/13/20

Central Coast Voices is sponsored by ACTION for Healthy Communities in collaboration with KCBX and made possible through underwriting by Joan Gellert-Sargen.

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Central Coast Voices: COVID-19 and its impact on non COVID care - KCBX

Your doctor diagnoses you with high blood pressure, orders various tests and sends you home with a prescription to keep it under control.

Thats the old-school model of a typical healthcare experience.

UCI Health, with its emphasis on evidence-based integrative health, is new-school, with world-class specialists who treat the immediate symptoms of heart disease and other conditions, as well as the mind and spirit of patients.

In addition to running traditional tests, integrative health doctors and nurses also conduct sophisticated diagnostic assessments and examine patients health history and lifestyle in depth including diet, exercise habits and other factors to devise a treatment plan.

Its a whole-person approach, says Dr. Ailin Barseghian, who specializes in preventive cardiology and integrative heart health at UCIs Susan Samueli Integrative Health Institute.

An assistant clinical professor in the School of Medicine, she is one of many physicians who will be offering this integrative approach to wellness at UCI Health Newport Beach, a multispecialty medical office opening in August in the Newport Center business complex surrounding Fashion Island.

The emphasis on integrative health at the new clinic, located at 2161 San Joaquin Hills Road, is being spearheaded by UCI Health cardiologist Shaista Malik, executive director of the Susan Samueli Integrative Health Institute and founding associate vice chancellor for integrative health at UCIs Susan and Henry Samueli College of Health Sciences.

UCI Health Newport Beachs services will include integrative cardiology, gastroenterology, dermatology and pain management, along with such therapies as acupuncture, massage, naturopathic medicine, mindfulness and yoga.

Reducing risk factors

With advanced testing and other supportive treatments, Barseghian says, we can personalize care for each individual and help reduce their risk factors for cardiovascular disease.

To be sure, traditional cardiologists also recommend that patients improve their diets, exercise a certain number of times each week and make other lifestyle changes, she says, but with integrative cardiology, we work as a team that includes an exercise specialist, a dietitian and other therapists to help guide people.

With a patient who has high blood pressure, for example, the goal is to get to the root of the problem, Barseghian explains: We assess nutrition and fitness, as well as sleep patterns and any possible stressors such as whether someone is going through a divorce or a difficult time on the job to see if theres an underlying cause. We might also try acupuncture, which studies show can lower blood pressure if a regular regimen is maintained.

Whats different about UCI Health Newport Beach, she adds, is that specialty care and most integrative health services are available in one location. The clinic is 7,000 square feet and will employ 13 non-provider staff members, with about five providers working each day.

Its certainly a unique resource in this area, Barseghian says. Some of these complementary therapies, like acupuncture, arent new. Were just including them when it comes to assessing the overall health of our patients.

Dedicated physicians

Barseghian, who graduated from New York Medical College, did most of her training at UCI. She completed an internal medicine residency and cardiovascular disease fellowship at UCI Medical Center, followed by a fellowship in interventional cardiology at Lenox Hill Heart and Vascular Institute in New York City.

Shes been on the faculty at UCI for five years and currently is seeing patients at the Susan Samueli Integrative Health Institute in Costa Mesa, UCI Health Tustin and the UCI Health Cardiovascular Center in Orange.

When I did my general cardiology training here, she says, I linked up with Dr. Malik. She had already started the preventive cardiology program, and I focused my training on that. She was my mentor.

Stress management, Barseghian notes, is an important element of integrative cardiology.

For instance, she says, its not uncommon to see blood pressure or a heart rate change based on stressors, especially prolonged or situational stress. And those are hard to manage with traditional pharmaceutical therapy, because the stressor still can surpass the medication benefit. So the focus then becomes finding ways to manage that stress to avoid a surge in blood pressure.

I love my work, Barseghian continues. In medicine, the biggest drive is your connection with your patients and having the opportunity to help and guide them. As an interventional cardiologist, I put in stents and treat heart attacks, and I see the disease progression. Being able to concentrate on prevention from the integrative standpoint just gives me more tools beyond the traditional pharmacological one.

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Treating mind, body and spirit - UCI News

RENO, Nev. Nevada ENT and Hearing Associates announced Aug. 3 that Dr. Keely Chevallier joined the Reno-based practice.

According to an Aug. 3 press release, Dr. Chevallier, a Nevada native, comes from David Grant Medical Center at Travis Air Force Base, where she served as an Active Duty Air Force officer for four years, most recently as the Officer in Charge of the combined ENT, Audiology and Speech Language Pathology Clinic, and the Surgical Champion for the Hospitals Informatics Steering Committee.

She served a tour in Afghanistan in 2018 as the only NATO forces ENT in the country. During this time, she took care of patients including U.S. Service Members, NATO forces and Afghan troops, providing care for traumatic injuries, respiratory failure and all diseases of the ears, nose, and throat.

Dr. Chevallier received a Bachelor of Arts in integrative biology from University of California, Berkeley. She received her Doctor of Medicine degree from University of Colorado, School of Medicine in Aurora, Colorado and completed her residency in Otolaryngology/Head and Neck Surgery at University of Utah Hospital in Salt Lake City, Utah.

Dr. Chevallier has been a member of the Alpha Omega Alpha Medical Honor Society since 2009 and has been board certified with the American Board of Otolaryngology since 2017.

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People: Keely Chevallier joins Nevada ENT and Hearing Associates - Northern Nevada Business Weekly

Cannabis with THC levels over 10 per cent became the strongest predictor of success in treating migraine- and headache-related pain.

For the first time, researchers have focused on dried cannabis flower as treatment for headaches and migraines.

Published in the Journal of Integrative Medicine, the study examined, in real time, the associations between different product characteristics and changes in symptom intensity following cannabisuse.

Interestingly, results showcased that flower was, indeed, effective for migraines, but the specifics of the cannabis plant (gender, age and combustion methods) may decrease effectiveness.

One key finding determined that cannabis with tetrahydrocannabinol (THC) levels over 10 per cent became the strongest predictor of success in treating migraine- and headache-related pain with cannabis.

Additionally, the C. indica strain offered greater success with individuals in the study over its C. sativa counterpart. Overall, for those seeking migraine relief and for healthcare professionals looking to treat those who have headaches, the study could be an important conversation starter for better outcomes against pain.

Results of the study offer insight into how cannabis looks to not only alleviate, but could eliminate, migraine pain for some users. With more than 94 per cent of users experiencing symptom relief within two hours, the study has brought to light deeper conversations around cannabis role in pain and quality-of-life for those experiencing headache-related disorders.

The research joins another study that looked into the prolonged use of cannabis for individuals who suffer migraines. Published in May in Brain Sciences, the study found that frequent cannabis use decreased migraine frequency.

Another study found that frequent cannabis use decreased migraine frequency. / Photo: iStock / Getty Images PlusiStock / Getty Images Plus

These findings indicate that MC [medical cannabis] results in long-term reduction of migraine frequency in more than 60 per cent of treated patients and is associated with less disability and lower anti-migraine medication intake.

Cannabis and CBD have attracted interest in migraine treatments in the last few years with organizations looking to alternative medicine to offer a needed solution for those who dont want to use opioids.

The Migraine Research Foundation gave Dr. Nathaniel Schuster from the University of California San Diego funding for his research on cannabis in 2018. Additionally, the American Headache Society and the American Migraine Foundation have both expressed the need for more research around cannabis and CBD for migraine relief.

The FreshToast.com, a U.S. lifestyle site that contributes lifestyle content and, with their partnership with 600,000 physicians via Skipta, medical marijuana information to The GrowthOp.

Want to keep up to date on whats happening in the world of cannabis?Subscribeto the Cannabis Post newsletter for weekly insights into the industry, what insiders will be talking about and content from across the Postmedia Network

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What a new study reveals about cannabis and migraines - The GrowthOp

Yoga improves symptoms of generalized anxiety disorder, a condition with chronic nervousness and worry, suggesting the popular practice may be helpful in treating anxiety in some people.

Led by researchers at NYU Grossman School of Medicine, a new study found that yoga was significantly more effective for generalized anxiety disorder than standard education on stress management, but not as effective as cognitive behavioral therapy (CBT), the gold standard form of structured talk therapy that helps patients identify negative thinking for better responses to challenges.

Generalized anxiety disorder is a very common condition, yet many are not willing or able to access evidence-based treatments, says lead study author Naomi M. Simon, MD, a professor in the Department of Psychiatry at NYU Langone Health. Our findings demonstrate that yoga, which is safe and widely available, can improve symptoms for some people with this disorder and could be a valuable tool in an overall treatment plan.

For the study, 226 men and women with generalized anxiety disorder were randomly assigned to 3 groupsCBT, Kundalini yoga, or stress management education, a standardized control technique.

After three months, both CBT and yoga were found to be significantly more effective for anxiety than stress management. Specifically, 54 percent of those who practiced yoga met response criteria for meaningfully improved symptoms compared with 33 percent in the stress education group. Of those treated with CBT, 71 percent met these symptom improvement criteria.

However, after six months of follow-up, the CBT response remained significantly better than stress education (the control therapy), while yoga was no longer significantly better, suggesting CBT may have more robust, longer-lasting anxiety-reducing effects. The results were published online August 12 in JAMA Psychiatry.

The study involved an evidence-based protocol for CBT treatment of generalized anxiety disorder, including psychoeducation, cognitive interventions (focused on identifying and adapting maladaptive thoughts and worrying), and muscle relaxation techniques.

Kundalini yoga included physical postures, breathing techniques, relaxation exercises, yoga theory, and meditation and mindfulness practice.

The stress management education control group received lectures about the physiological, psychological, and medical effects of stress, as well as the antianxiety effects of lifestyle behaviors, such as reducing alcohol and smoking, and the importance of exercise and a healthy diet. Homework consisted of listening to educational material about stress, nutrition, and lifestyle.

Each treatment was administered in groups of 3 to 6 participants, over weekly 2-hour sessions for 12 weeks with 20 minutes of daily homework assigned.

According to researchers, generalized anxiety disorder is a common, impairing, and undertreated condition, currently affecting an estimated 6.8 million Americans. While most people feel anxious from time to time, it is considered a disorder when worrying becomes excessive and interferes with day-to-day life. CBT is considered the gold standard first-line treatment. Medications, including antidepressants and sometimes benzodiazepines, may also be used. Yet, not everyone is willing to take medication, which can have adverse side effects, and there are challenges with accessing CBT for many, including lack of access to trained therapists and long waitlists.

Many people already seek complementary and alternative interventions, including yoga, to treat anxiety, says Dr. Simon. This study suggests that at least short-term there is significant value for people with generalized anxiety disorder to give yoga a try to see if it works for them. Yoga is well-tolerated, easily accessible, and has a number of health benefits.

According to Dr. Simon, future research should aim to understand who is most likely to benefit from yoga for generalized anxiety disorder to help providers better personalize treatment recommendations.

We need more options to treat anxiety because different people will respond to different interventions, and having more options can help overcome barriers to care, she says. Having a range of effective treatments can increase the likelihood people with anxiety will be willing to engage in evidence-based care.

Along with Dr. Simon, other authors of this study are Stefan G. Hofmann of Boston University; David Rosenfield at Southern Methodist University in Dallas; Susanne S. Hoeppner and Eric Bui of Massachusetts General Hospital, Harvard Medical School in Boston; Elizabeth A. Hoge of Georgetown University Medical Center in Washington, D.C.; and Sat Bir S. Khalsa of Brigham and Womens Hospital, Harvard Medical School in Boston.

Funding for the work came from the National Center for Complementary and Integrative Health grants R01 AT007258 and R01 AT007257 to Dr. Simon and Dr. Hofmann.

Ashley WelchPhone: 212-404-3511ashley.welch@nyulangone.org

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Yoga Shown to Improve Anxiety, Study Finds | NYU Langone News - NYU Langone Health

According to latest research report on Global Health Coaching Market report provides information related to market size, production, CAGR, gross margin, growth rate, emerging trends, price, and other important factors. Focusing on the key momentum and restraining factors in this market, the report also provides a complete study of future trends and developments in the market.

The Health Coaching report contains all the details of the expected market dynamics and new market opportunities due to the COVID-19 outbreak. Stratagem Market Insights tried to cover all the market analysis of annual economic growth in the latest report on the Health Coaching market.

According to analysts, the growth of the Health Coaching market will have a positive impact on the global platform and will witness gradual growth over the next few years. This report study incorporates all the market growth and restraining factors along with the important trends mentioned between 2020 and 2025.

Request Sample Copy of this Report @ https://www.express-journal.com/request-sample/168077

Market segmentation:

The Health Coaching market has been segmented into a variety of essential industries including applications, types, and regions. In the report, each market segment is studied extensively, taking into account market acceptance, value, demand, and growth prospects. Segmentation analysis allows customers to customize their marketing approach to make better orders for each segment and identify the most potential customers.

Global Health Coaching Market Segmentation by Application:

Global Health Coaching Market Segmentation by Product:

Competitive Landscape

This section of the report identifies various major manufacturers in the market. It helps readers understand the strategies and collaborations players are focusing on fighting competition in the marketplace. The comprehensive report gives a microscopic view of the market. The reader can identify the manufacturers footprint by knowing about the manufacturers global revenue, the manufacturers global price, and the manufacturers production during the forecast period.

The major manufacturers covered in this report:

Regional Insights of Health Coaching Market:

In terms of geography, this research report covers almost all major regions around the world such as North America, Europe, South America, Middle East, Africa, and the Asia Pacific. Europe and North America are expected to increase over the next few years. Health Coaching markets in the Asia-Pacific region are expected to experience significant growth during the forecast period. Advanced technology and innovation are the most important characteristics of North America and the main reason why the United States dominates the world market. The Health Coaching market in South America is also expected to expand in the near future.

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Important Facts about Health Coaching Market Report:

Questions Answered by the Report:

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Global Health Coaching Market Potential Growth, Share, Demand and Analysis of Key Players- Research Forecasts to 2025 - Express Journal

By Deepali Singh

Are acidity and constipation causing you discomfort? Experts list a few self-help techniques to get respite

All that late-night bingewatching and midnight snacking has not only caused our sleeping patterns to go haywire, but its also one of the reasons for more and more people complaining about stomach-related ailments.

A sedentary lifestyle coupled with irregular eating hours and poor dietary patterns are reasons enough for the rise in several tummy issues such as bloating, acidity and constipation, says Dr Roy Patankar, gastroenterologist and director of Zen Multi Speciality Hospital, Chembur.

With limited physical activity, lesser access to fresh vegetables and fruits, increase in consumption of junk food, late-night snacking and anxiety related to Covid-19, peoples lifestyle has undergone a major change in these times, says Dr Patankar. If there are serious symptoms such as black coloured stool, weight loss, vomiting or unexplained pain that lasts for too long or the problem persists for more than 48 hours, then we suggest tele-consultations with the doctor. However, before you rush to the doctor, a few self-help techniques might come in handy to keep your digestive system in top order.

Eat right

Apart from keeping a whole lot of health problems at bay, a nutritious diet consisting of vegetables, fruits, nuts, seeds and whole grains are recommended to keep your stomach in order too. To combat acidity issues, Luke Coutinho, holistic lifestyle coach, Integrative Medicine suggests alkaline foods such as cucumber, fennel seeds, coriander seed tea and kokum infused water. He also suggests lukewarm water for constipation problems and adequate fibre, as that helps form the bulk of the stool. Certain spices such as asafoetida, cumin, and bishops weed are known to have carminative properties; they reduce the gas-forming ability of food, he adds. Abstaining from excess tea and coffee is a good idea as it makes our system acidic, he adds. While including raw food is good, overdoing it in the name of fibre isnt advised, as it can irritate the walls of our digestive system. Sugar and junk foods also alter the ratio of good and bad bacteria in the gut and feed the bad bacteria. They can also cause inflammation of the gut linings, he adds.

With the rainy weather being a good excuse to binge on fried snacks, a common scenario is to reheat the oil for cooking. But reheating the oil again and again can generate a lot of free radicals thereby leading to inflammation or exacerbating already existing inflammation, and therefore, should be avoided, says Coutinho.

At times, overdoing the good stuff may also lead to trouble. According to Dr Patankar, consuming large quantities of raw garlic and ginger which some people have been doing to strengthen their immune system can also play havoc with the digestive system.

Some basic rules

Drinking adequate amounts of water and focusing completely on meals without multi-tasking are also good habits to inculcate for a healthy digestive system. Coutinho also suggests smart fasting to reset your digestive system. It gives our digestion space and opportunity to heal, cleanse, and recover, he adds. By far, a lifestyle change of 12-hour gap between dinner and next days meal is one of the most effective lifestyle changes ever made for acidity, constipation, bloating and indigestion.

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THAT FIRE IN YOUR BELLY - Mumbai Mirror

In addition to low-glycemic fruits and veggies, as part of your balanced diet, it's important to include plenty of fiber and a variety of macronutrients.

"Getting enough fiber each day is essential for healthy blood sugar levels," says Frances Largeman-Roth, RDN, nutrition expert and author of Smoothies & Juices: Prevention Healing Kitchen. "Adults should get 25 to 35 grams each day, but most of us fall short. If you spread it out to five meals (including snacks) a day, that's 5 grams of fiber per meal."

However, if you're struggling to maintain a consistent nutrient intake (fiber or otherwise), one great solution is a greens powder, which includes dried, powdered forms of various vegetables, fruits, and other nutritious ingredients.* One study found that adding a vegetable powder to a high-carbohydrate diet helped buffer the short-term glucose and insulin response.*

mindbodygreen's organic veggies+, in particular, was designed to help support healthy blood sugar. In addition to a number of nutritious leafy greens and veggies, it features a fiber blend of flaxseed and inulin.

"It also provides cinnamon bark, which promotes healthy blood sugar balance by slowing the breakdown of carbohydrates during digestion,*" Jessica Cording, M.S., R.D., CDN, previously told mindbodygreen. In fact, some studies suggest that cinnamon promotes healthy blood sugar by increasing insulin sensitivity, or making insulin more efficient at moving glucose into cells.*

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3 Expert-Backed Ways To Support Healthy Blood Sugar Levels - mindbodygreen.com

More than 500 clinical trials are under way world-wide in the race to find an effective treatment for Covid-19. Everybody wants it; nobody has ityet. But one of the most promising therapies for Covid-19 patients uses medicinal signaling cells, or MSCs, which are found on blood vessels throughout the body.

In preliminary studies, these cells cut the death rate significantly, particularly in the sickest patients. With a powerful 1-2-3 punch, these cells eliminate the virus, calm the immune overreaction known as a cytokine storm, and repair damaged lung tissuea combination offered by no other drug. This type of regenerative medicine could be as revolutionary as Jonas Salks polio vaccine.

In one pilot study in March, doctors at Mount Sinai Hospital in New York treated a dozen severely ill Covid-19 patients on ventilators with MSCs. Two infusions modulated their hyperactive immune systems, and 83% of those patients survived. With such promising results, the team at Mount Sinai and the supplier of the cells, Mesoblast Ltd., won Food and Drug Administration clearance and National Institutes of Health funding to conduct a randomized trial on 300 patients. The first patients in the trial received the treatment in early May.

A July 10 article in the Lancet reported on 13 critically ill Covid-19 patients also treated with MSCs. Eleven of the 13 patients livedan 85% survival rate, which mirrors the results from Mount Sinai. The number of virus-fighting T-cells rose even as inflammation fell, suggesting that these cells can control the immune response as needed. In addition, chest X-rays showed that the drug repaired lung tissue, in some cases within 48 hours.

Healing tissue is essential because the cytokine battle with the Covid-19 virus is so vicious that it punches holes in the delicate lung membranes, allowing the virus to flood into the bloodstream and body cavities. These holes must be repaired, as virus leaks create some of the complications not usually associated with respiratory infectionsblood clotting, heart attacks, stroke and multiple organ failure, which cause about 40% of Covid-19-related deaths. Blood-vessel density, and thereby the number of MSCs, decreases as we age, gain weight or develop diseases, which may explain why the elderly and those with chronic health conditions are faring worst.

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The Treatment That Could Crush Covid - The Wall Street Journal