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What Vir Biotechnology, Inc. (VIR) Doesnt Want You to Know – The News Heater

August 28th, 2020 11:55 pm

Vir Biotechnology, Inc. (NASDAQ:VIR) went down by -5.86% from its latest closing price when compared to the 1-year high value of $75.00 and move down -82.48%, while VIR stocks collected -20.79% of loss with the last five trading sessions. Press Release reported on 08/20/20 that Vir Biotechnology Presents Data on VIR-2218 from Clinical Studies for the Treatment of Hepatitis B at the EASL Digital International Liver Congress(TM)

Vir Biotechnology, Inc. (NASDAQ:VIR) 4 of the analysts out of 7 who provided ratings for Vir Biotechnology, Inc. stocks as a buy while 0 as overweight, 1 rated it as hold and 1 as sell. The average price we get from analysts is $49.17 which is $2.9 above current price. VIR currently has a short float of 3.60% and public float of 109.09M with average trading volume of 1.27M shares.

VIR stocks went down by -20.79% for the week, with the monthly drop of -13.42% and a quarterly performance of 20.25%. The simple moving average for the period of the last 20 days is -18.00% for VIR stocks with the simple moving average of 32.99% for the last 200 days.

Many brokerage firms have already submitted their reports for VIR stocks, with Needham repeating the rating for VIR shares by setting it to Buy. The predicted price for VIR socks in the upcoming period according to Needham is $62 based on the research report published on August 20, 2020.

JP Morgan, on the other hand, stated in their research note that they expect to see VIR stock at the price of $26. The rating they have provided for VIR stocks is Underweight according to the report published on March 19, 2020.

Goldman gave Neutral rating to VIR stocks, setting the target price at $26 in the report published on March 13, 2020.

After a stumble in the market that brought VIR to its low price for the period of the last 52 weeks, Vir Biotechnology, Inc. was unable to take a rebound, for now settling with -45.20% of loss for the given period.

The stock volatility was left at 6.78%, however, within the period of a single month, the volatility rate increased by 10.34%, while the shares sank at the distance of -12.66% for the moving average in the last 20 days. In oppose to the moving average for the last 50 days, trading by +10.84% upper at the present time.

In the course of the last 5 trading sessions, VIR went down by -20.79%, which changed the moving average for the period of 200 days to the total of +209.72% of gains for the stock in comparison to the 20-day moving average settled at $49.83. In addition, Vir Biotechnology, Inc. saw 226.84% in overturn over the period of a single year with a tendency to cut further gains.

Reports are indicating that there were more than several insider trading activities at Vir Biotechnology, Inc. (VIR), starting from Pang Phillip, who sold 12,500 shares at the price of $50.95 back on Aug 19. After this action, Rushing now owns 29,777 shares of Vir Biotechnology, Inc., valued at $636,855 with the latest closing price.

Virgin Herbert, the EVP, Research & CSO of Vir Biotechnology, Inc., sold 7,900 shares at the value of $51.08 during a trade that took place back on Aug 11, which means that Virgin Herbert is holding 0 shares at the value of $403,563 based on the most recent closing price.

The current profitability levels are settled at -2144.35 for the present operating margin. The net margin for Vir Biotechnology, Inc. stands at -2158.98. Total capital return value is set at -62.52, while invested capital returns managed to touch -62.97. Equity return holds the value -81.10%, with -42.30% for asset returns.

Based on Vir Biotechnology, Inc. (VIR), the companys capital structure generated 0.27 points for debt to equity in total, while total debt to capital is set at the value of 0.27.

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Is Ibio Inc (IBIO) the Top Pick in the Biotechnology Industry? – InvestorsObserver

August 28th, 2020 11:55 pm

Ibio Inc (IBIO) is around the bottom of the Biotechnology industry according to InvestorsObserver. IBIO received an overall rating of 34, which means that it scores higher than 34 percent of all stocks. Ibio Inc also achieved a score of 21 in the Biotechnology industry, putting it above 21 percent of Biotechnology stocks. Biotechnology is ranked 31 out of the 148 industries.

Trying to find the best stocks can be a daunting task. There are a wide variety of ways to analyze stocks in order to determine which ones are performing the strongest. Investors Observer makes the entire process easier by using percentile rankings that allows you to easily find the stocks who have the strongest evaluations by analysts.

These scores are not only easy to understand, but it is easy to compare stocks to each other. You can find the best stock in an industry, or look for the sector that has the highest average score. The overall score is a combination of technical and fundamental factors that serves as a good starting point when analyzing a stock. Traders and investors with different goals may have different goals and will want to consider other factors than just the headline number before making any investment decisions.

Ibio Inc (IBIO) stock is trading at $2.58 as of 10:05 AM on Tuesday, Aug 25, a rise of $0.37, or 16.52% from the previous closing price of $2.21. The stock has traded between $2.21 and $2.63 so far today. Volume today is less active than usual. So far 21,135,227 shares have traded compared to average volume of 45,691,093 shares.

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Revel Health and Coriell Life Sciences Partner to Drive Members to Take Action for Medication Risks – PRNewswire

August 28th, 2020 2:56 am

MINNEAPOLIS, Aug. 25, 2020 /PRNewswire/ -- Revel Health, a Minneapolis-based next-gen healthcare technology company, and Coriell Life Sciences (CLS), a Philadelphia-based bioinformatics company and leading provider of genetic interpretation and reporting, today announced a partnership designed to drive healthier action for Medicare Advantage members in relation to how their genes impact the effectiveness and efficacy of prescribed medications.

Today, about one-fifth of medications prescribed to elderly patients are inappropriate, and the safety and efficacy of more than 200 drugs are known to be impacted by a person's genes. Coriell Life Sciences specializes in precision medicine through pharmacogenetics, or the study of how people respond differently to drug therapy based upon their genetic makeup,and offers genetic panel testing for medication response. The genetic panel testing aims to help members understand how medications impact them based on their DNA.

"We're excited to work with Coriell Life Sciences on this new initiative to empower members to take action to understand how medications personally impact them," said Jeff Fritz, CEO of Revel Health. "CLS is committed to helping members understand how their genes can impact a response to certain medications, and this commitment shows in their desire to use the latest tools and techniques in driving healthier action."

Utilizing Revel Connect, Revel Health's health action platform, CLS and Revel Health have partnered to communicate the genetic testing offering to members and build a multi-channel program aimed to drive members to take action to understand their personal medication risk.

Revel Health and CLS launched the first wave of a program in June to reach more than 22,000 Medicare Advantage members via a multi-channel approach including text, email, interactive voice (IVR) and mail to communicate the importance of DNA testing for medication efficacy and to drive members to work with CLS to get tested.

"Each year there are more than 275,000 deaths attributable to medication errors and the reality is that medications impact each of us differently based on our genetics," said Scott Megill, President and CEO at Coriell Life Sciences. "Our goal is to protect the most vulnerable, and Revel Health was a natural digital partner in helping us to deliver on this goal. Revel Health's platform has enabled us to communicate with vulnerable populations and grow their understanding of the impact of medications they're taking based on their genetics."

Revel Connect, Revel Health's platform uses data science, behavioral research, and multi-channel tools to investigate the social barriers and personal attributes that impact health plan members to take action to complete a DNA test. Then, based on each member's unique needs, Revel Health's advanced technology builds targeted multi-channel digital communications that prompt members to engage with resources and take health action in real time, ultimately driving healthier outcomes in relation to medication risk.

About Revel Health

Revel Health is a healthcare technology company that is reinventing health engagement to make it better through its industry-leading health action platform, Revel Connect. Revel Health helps healthcare organizations connect with members and patients in a personalized way to build better healthcare consumer experiences, drive positive health action, and improve health outcomes. Follow Revel Health onTwitter and connect with us onLinkedIn. Learn more about who we are and our approach by visiting us atRevel-Health.com.

About Coriell Life Sciences (CLS)Coriell Life Sciences (CLS) is a trusted advisor in genetic science. On the cutting edge of precision medicine, we partner with customers to provide actionable solutions, informed by genetic knowledge, to reduce healthcare costs and empower a healthier world. We bridge the gap between genetic knowledge and clinical application. Coriell Life Sciences sets the gold standard in genetic interpretation and reporting and offers the most comprehensive medication risk management program on the market. Visit coriell.com, email [emailprotected] or follow @CoriellLife.

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Global Genomic Medicine Market to Witness Heightened Growth During the Period 2017 2025 – Scientect

August 28th, 2020 2:56 am

The National Human Genome Research Institute definesgenomic medicine asan emerging medical discipline that involves using genomic information about an individual as part of their clinical care (e.g., fordiagnostic or therapeutic decision-making) and the health outcomes and policy implications of that clinical use. Genomic medicine is a type of precision medicine in which genomics, epigenomics and other related data is used to accurately aid in individual disease diagnosis. Genomic medicine has novel applications in the fields of oncology, pharmacology, rare and undiagnosed diseases, and infectious disease.Genomic medicine paves way for personalized medicine into clinics and has immense potential to reach the physicians and patients. Genomic medicine has been used for advanced sequencing in cancer pharmacogenomics, rare disorder diagnosis and for tracking of outbreaks of infectious diseases.

Genomic Medicine Market: Drivers & Restraints

Backed by government investments in precision medicine initiatives such as a multimillion dollar investment by President Obama in January 2015 which aims to improve how to treat and prevent a disease by laying emphasis on its genetic makeup is expected to boost the market growth. Clinical validity and utility of genomic medicine tests is a major issue witnessed in the global market. Also, lack of awareness among healthcare professionals, sluggish adoption of genome medicine, fluctuating regulatory landscape are the factors which could hamper growth of the global genomic medicine market.

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Genomic Medicine Market: Segmentation

The global genomic medicine market is classified on the basis of application type, end use and region.

Based on application, the global genomic medicine market is segmented into the following:

Based on end use, the global genomic medicine market is segmented into the following:

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Genomic Medicine Market: Overview

Genomic medicine is gaining momentum with expanding applications ranging from risk assessment and diagnosis in healthy individuals to genome-based treatment for patients with complicated disorders. Oncology is a major application of genomics medicine during cancer screening process as diagnostics for genetic and genomic markers. Oncology segment is expected to account for a major share in the global genomic medicine market. Genomic medicine is increasingly being used not only for research purpose but also in clinical applications. In clinical applications, genomic medicine will potentially enhance patient care.

Genomic Medicine Market: Region wise Overview

Geographically, global Genomic Medicine market is classified into regions viz. North America, Latin America, Western Europe, Eastern Europe, Asia Pacific Excluding Japan (APEJ), Japan, Middle East and Africa (MEA). Owing to the presence of large number of academic as well as research institutions in the U.S. which are working on genomic medicine to discover next-generation genomic medicines, North America region is projected to lead the global genomic market in terms of value during the forecast period. Also, the presence of several universities offering educational programs coupled with opportunities in scientific research of genomic medicine in the North America and Europe is expected to have positive impact on the regional markets. The genomic medicine concept still in its nascent stage is yet to receive an impetus from the emerging market which are anticipated to hold smaller shares in the global market.

Genomic Medicine Market: Key Players

The key research institutes in global genomic medicine market are BioMed Central Ltd., Cleveland Clinic, The University of Texas MD Anderson Cancer Center, The Manchester Centre for Genomic Medicine, Center for Genomic Medicine to name a few. The focus of the top players will be on the identification of effective drug candidates particularly in cancer treatment based on the molecular structure of tumors.

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Searching for more zzzs? There is a sleep app for that – WKTV

August 28th, 2020 2:56 am

As the global pandemic drags on, many of us are more stressed out than usual. And that often means scoring a lot less sleep at night.

"Trying to get good sleep while you're stressed out is like trying to make a half-court shot while blindfolded," said Michael Breus, a clinical psychologist in Los Angeles. Breus focuses on insomnia and high-performance sleep coaching, a three- to six-month program for CEOs, athletes and celebrities.

"You can do it, but it's really tough to pull off."

Let's say you have been feeling extra overwhelmed lately. That, Breus said, prompts your body to release cortisol, the primary stress hormone. This coincides with sugar (or glucose) entering the bloodstream, which elevates your blood pressure.

Next thing you know, Breus said, your muscles tense up, your heart pumps faster and your brain kicks into overdrive. It's the old fight-or-flight response you learned about in grade school. In other words, your body is now in survival mode.

That is what makes falling asleep very tricky.

When that stress persists week after week, the body adjusts to the higher cortisol levels. This continues to prevent you from getting quality shut-eye but can also lead to serious problems like heart disease, hypertension, diabetes and depression, according to Breus.

Enter these sleep-focused apps.

We use apps for just about everything, so why not use them to help us out when it comes to sleep, right? Perhaps. It depends on what type of sleep issue you are having, since Breus said there are 88 different sleep disorders.

"I think that apps will be helpful for people to manage stress, become educated and learn about their sleep environment," Breus said.

When looking for an app, first consider what is keeping you from sleeping and what the app is going to address. Do you need to quiet your noisy environment, ease your stress levels or address a diagnosed condition?

Make sure to think of it as a tool, not as a stand-alone solution that can solve your unique situation. And keep in mind, it's best to place the phone face down so the screen light doesn't bother you. For most of the apps, you can also download content and put your phone in airplane mode, so you won't receive calls or texts while attempting to snooze.

Here are some expertly curated apps, chosen by Breus and New York City-based psychologist Joshua Tal, who specializes in treating sleep disorders.

If your sleep issues persist, make sure to consult with your doctor for personalized medical advice. Many medical professionals are offering telehealth services during the pandemic.

Subscribe to CNN's Sleep, But Better Newsletter: Want the best sleep of your life? Sign up for our newsletter series for helpful hints to achieve better sleep.

Some relaxation apps lull you into dreamland with sounds of the Amazon rainforest or monitor your sleep habits throughout the night. Others incorporate meditation to help reduce stress levels before bedtime. And some, designed specifically for insomniacs, require a prescription.

"I usually recommend nature and white-noise apps for clients that have a snoring bed partner or loud noises outside," Tal said.

Portal ($29.99 per year), for example, is an app that uses immersive 3D sounds -- think gentle waves in Hawaii, a log fire in Switzerland or a whale encounter in Tahiti -- as a way to help you get ready for bed.

"It can be a good wind-down, pre-bedtime activity," Tal said.

Other noise-blocking apps include White Noise Generator, Relax Melodies and myNoise.

Breus said he's impressed with Pzizz ($9.99 per month), an app that uses binaural beats, with two different frequencies played in each ear. Plus, there is a man's voice encouraging you to relax. Don't worry: You can mute this if you'd like. The user can also schedule bedtime reminders, as well as nap reminders.

BrainTap Pro ($9.99 per month), another mobile app that Breus recommended, is designed to retrain the brain and also incorporates binaural beats. This one combines those beats with guided visualization, 10-cycle holographic music (a sonic technology that produces a 360-degree sound environment) and isochronic tones, which are equal-intensity pulses of sound followed by moments of silence. It's all meant to create a balanced brainwave state.

Headspace and Calm, recommended by Tal, offer sleep mediations and relaxation exercises.

Headspace ($12.99 per month) includes sleepcasts, a 45-minute audio recording (think of it as a bedtime story) that uses sound, breathing exercises and visualization to help put you in a tranquil mood.

There are also sleep music, wind-down activities, soundscapes and guided exercises to help with waking up in the night. The 45- to 55-minute audio sessions aim to help you visualize a calm scene.

The Calm app ($69.99 per year) is similar. Users choose from more than 100 hours of soothing music, guided meditations and narrated sleep stories by celebrities like Kelly Rowland, Lucy Liu and Matthew McConaughey.

Likewise, Restflix ($7.99 per month), which Breus recommended, is a streaming service with hundreds of hours of sleep meditations, bedtime stories, serene landscapes, binaural beats and nature sounds to help people develop better sleep habits.

Tal said sleep-tracking apps such as Sleep Cycle, Sleep Genius, Sleep Score and Pillow can be helpful for those with mild sleep issues as a way to improve sleep environment and regimen. These apps certainly won't give you the results you'd get by visiting a traditional sleep center, but they can help identify patterns.

When it comes to complicated sleep issues like insomnia and sleeplessness, Breus said, online digital coaching options offer a targeted approach, help pinpoint problems and have great data supporting them.

Somryst, a nine-week prescription digital therapeutic for chronic insomnia, which will be commercially available in the third or fourth quarter of 2020, must by prescribed and monitored by a licensed health care provider. It uses technology to deliver cognitive behavioral therapy for insomnia digitally through a smartphone or a tablet.

Similar to traditional face-to-face CBT-I, Somryst uses tailored sleep restriction and consolidation; stimulus control; and personalized cognitive restructuring to improve insomnia symptoms. Along with that, there is a clinician-facing dashboard to track patient treatment and progress.

Cognitive behavioral therapy for insomnia has been recommended as the first-line treatment for chronic insomnia since 2016 by the American College of Physicians and the American Academy of Sleep Medicine.

"Somryst is the first FDA market authorized prescription digital therapeutic intended to treat patients age 22 years of age and older with chronic insomnia and the only FDA authorized therapeutic that delivers guideline recommended first-line treatment for chronic insomnia," said Dr. Yuri Maricich, chief medical officer at Pear Therapeutics, the company that created Somryst.

Whether you need to block out that barking dog next door or need help coaxing your mind to slow down, there is certainly an app to address the issue. But don't be discouraged if it's tough to figure out right away. Sleep is complicated, said Breus, and there are many reasons a person could have insomnia like stress or work schedule. Apps will never cover all these factors or even most of them.

"An app may be designed for one or two aspects of a person's problem," he said, "but none of these are personalized, like a person would have in a session with a therapist."

Seeking help from a sleep psychologist first can be the best approach so that a specialist pinpoints the problem and guides you toward the right apps.

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Global Medical Wellness Market to Witness Increased Revenue Growth Owing to Rapid Increase in Demand – Scientect

August 28th, 2020 2:56 am

Wellness describes itself as complete physical mental and social well-being. It comprises all the components used to lead a healthy life. Wellness is multidirectional and constitutes social, emotional, physical, spiritual, intellectual and emotional wellbeing. According to National Wellness Institute, two more component of wellness includes cultural and environmental wellness. Mental health and well-being are an integral and essential component of health. Wellness goes further than disease or disability and highlights the maintenance and improvement of health and well-being of the person. Wellness includes activities that improve health, enhance the quality of life and increase the levels of well-being of the person. Different types of wellness include workplace wellness, wellness tourism, lifestyle wellness and others. In order to help prevent disease, reduce stress, and enhance the overall quality of life Global Wellness Institute (GWI) organizes e Global Spa & Wellness Summit (GSWS) annually, that brings together leaders and visionaries to discuss various aspects of health and wellbeing.

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Nowadays, people are focusing on preventive, proactive aspects of wellness, wellness economy incorporates industrial sector that enables consumers to incorporate wellness into their lives. Consumers are inclining towards preventive measures to prevent diseases and maintain good health. The key sector of wellness includes wellness tourism, fitness, complementary & alternative medicine, lifestyle wellness, rejuvenation and spa industry, workplace wellness and others.

Wellness is self-responsibility and is opening new opportunities for wellness market as due to increase in geriatric population, rise in disease population due to sedentary lifestyle, new research on wellness procedures using alternative medicines, expansion of consumer base and wellness industries, tourism is growing, that will incorporate wellness into travel, shift of consumers towards personal care products are some of the factors that will drive the medical wellness market. The awareness about medical wellness will help consumers, spread wellness to homes and their workplace and help the right way to exercise, include healthy eating in their diet, focus on preventive and personalized health and others. Lack of awareness about medical wellness, rise in products and services of wellness industry, lack of workforce and others are some of the factors restraining the market growth.

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The global medical wellness market is segmented on basis of wellness sector, distribution channel and geography:

Segment by Wellness Sector

Segment by Distribution Channel

The global medical wellness market is segmented into wellness sector and distribution channel. Based on the wellness sector, the medical wellness market is segmented into complementary and alternative medicine, beauty care and anti-aging (surgical and non-surgical), preventative and personalized medicine, healthy eating, nutrition and weight loss, rejuvenation and others. The beauty care and anti- aging segment will dominate the wellness market due to rise in number of aesthetics procedures and increase in number of beauty care wellness sectors. Based on the end user, the medical wellness market is segmented as franchise and company owned outlets. The global medical wellness market is going to increase significantly is near future due to shift of consumers towards proactive approaches and include wellness in day to day life

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By regional presence, the global medical wellness market is segmented into five broad regions viz. North America, Latin America, Europe, Asia-Pacific, and the Middle East & Africa. North America market is expected to dominate in terms of revenue share, owing to the high availability of advanced products and services, wellness tourism, expenditures growth, , increasing penetration of leading companies in the region along with increase in patient population. Significant economic development has led to an increase in healthcare availability in Asia Pacific region, growing number of multi-specialty care centers, rejuvenation and fitness centers and penetration of global players in Asia is expected to fuel the medical wellness market

Some of the major players in medical wellness market are Enrich Hair & Skin Solutions, VLCC Wellness Center, Guardian Lifecare, Healthkart, WTS International, The Body Holiday, Bon Vital, Biologique Recherch, MINDBODY Inc., Massage Envy, ClearCost Health, Golds Gym International, Inc., World Gym, Spafinder Wellness 365, Kaya Skin Clinic, Body master and others

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Medical Bioinformatics Market shares and strategies of key players – BioSpace

August 28th, 2020 2:56 am

Bioinformatics involves the development and application of novel informatics techniques in the field of biology. It improves the methods of storing, organizing, retrieving and analyzing biological data. Major activity in bioinformatics is to develop software tools in order to generate useful biological knowledge database. In molecular biology, bioinformatics techniques such as signal processing allow extraction of useful results from large amount of raw data. In the field of genetics it helps in sequencing, annotating genomes and to observe mutations. Bioinformatics study acts a biological literature and developmental data bank for biology related data.

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Similarly, biomedical informatics is an emerging discipline which defines the study of inventions and implementation of structures, algorithms to improve communication, understanding and managing the medical information. The National Center for Toxicological Research (NCTR) conducts research in bioinformatics and chemo informatics. The bioinformatics tools were created for analysis and integration of genomics, proteomics, metabolomics datasets and transcriptomics.

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The growth of global medical bioinformatics market is driven by increasing initiatives and funding, use of bioinformatics in drug discovery and biomarkers. The market is expected to offer opportunities with the introduction and adoption of upcoming technologies such as cloud computing and other sequencing technologies. The global medical bioinformatics market can be segmented by tools approved from Food and Drug Administration (FDA) or European Federation for Medical informatics (EFMI) for further research process.

Medical Bioinformatics market is based on the tools, application and end users.

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The global medical bioinformatics market can be segmented based on types of tools and the list of bioinformatics tools approved by FDA are as follows:

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The global medical bioinformatics market can be segmented by application as follows:

The global medical bioinformatics market can be segmented by end user as follows:

Medical bioinformatics market is segmented into five major regions: North America, Europe, Latin America, Asia Pacific, and Rest of World. North America leads the market followed by the European nations in terms of revenue. Globally, the medical bioinformatics market growth is expected to increase with the demand in development of generic drug development and mode of sequencing the genes in order to have prevalence from various diseases. In 2015, Department of Biomedical Informatics was inaugurated at Harvard Medical School. This was initiated in order to bring quantitative methods and technological development to biomedicine engineering research. According to Harvard Medical School, Department of Biomedical Informatics (DBMI) and research associates planned to break the wall of autism by detecting the disorder in newborns using the same standard of testing device used to check for hearing impairment. According to Food and Drug Administration, collaboration with National Center for Toxicological Research has driven the demand and use of bioinformatics tools such as predicting patient-specific treatment outcomes with in silico tools. Latin America and Asia Pacific regions are anticipated to be the emerging markets in the global medical bioinformatics market during the forecast period. The effective guidelines from EFMI reports the promotion of high standard application and development in medical bioinformatics. Increase in patient population base and rising disease incidences in the Asia Pacific region is expected to fuel the use of bioinformatics tools for research and tests, which is projected to propel the demand in global medical bioinformatics market in the forecast period.

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The key players in the global medical bioinformatics market develop bioinformatics tools, and software which is used in drug designing, sequencing methods. Some of the top players in the global medical bioinformatics market are Optra HEALTH, Affymetrix, Inc., Thermo Fisher Scientific Inc., Illumina, Inc., QIAGEN, Paraxel, Station X and others.

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M2GEN Announces the Launch of its Oncology-Focused Bioinformatics Support Services – PRNewswire

August 28th, 2020 2:56 am

TAMPA, Fla., Aug. 25, 2020 /PRNewswire/ --M2GEN announced today the launch of its oncology-focused Bioinformatics Support Services. Leveraging the results and knowledge gained from the ORIEN Avatar Program, an extensive, unique and ever-growing oncology clinico-genomics dataset, the M2GEN Bioinformatics team provides bioinformatics support services adhering to best-in-class standards.

M2GEN offers the following bioinformatics services: Paired Tumor and Germline Whole Exome Sequencing (WES) analysis with Panel of Normals (PoN) filtering, Tumor-Only Whole Exome Sequencing (WES) analysis with Virtual Normal (VN) somatic mutation classification, and Tumor-Only RNA Sequencing (RNA-Seq) analysis. Pipeline analysis is WES and RNA-Seq capture kit agnostic, and uses the most up to date human genome reference (GRCh38/hg38) and gene build (Gencode V32). All bioinformatics services are performed in HIPAA compliant and HI Trust certified cloud solutions.

M2GEN Bioinformatics Support Services utilize one of the largest Panel of Normals (PoN) available for high-quality somatic mutation calling. Over 20,000 germline samples from cancer patients inform the segregation of somatic and germline variants, and identify recurrent sequencing artifacts. In addition, the Avatar germline sequencing data is leveraged as a Virtual Normal (VN) cohort during Tumor-Only analysis, allowing for superior somatic mutation classification when patients' matched normal biospecimens are unavailable.

M2GEN's Bioinformatics Support Services are led by an experienced team of bioinformatics and computational biology experts trained at world-renowned scientific institutions such as Baylor College of Medicine Human Genome Sequencing Center, Memorial Sloan Kettering Cancer Center, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Sanger Institute and Columbia University.

"M2GEN now provides next generation sequencing analysis pipelines to customers in academia and biopharma industry. Our end-to-end bioinformatics solutions and pipelines are tuned for large-scale oncology multi-omics studies that allow our customers to dedicate more time to results interpretation and discovery," said Oliver Hampton PhD, Vice President of Bioinformatics & Biostatistics at M2GEN.

"M2GEN continues to expand its portfolio of data solutions, services, and technologies to be the best partner possible for its clients as we transform cancer care together and make precision medicine a reality," said Helge Bastian, PhD, President & CEO of M2GEN. "M2GEN's bioinformatics services enable researchers in academic and pharmaceutical research worldwide to gain the most meaningful molecular insights in oncology. These molecular insights will accelerate the development of novel and more effective patient specific therapies, turning cancer into a manageable condition, or better still a curable disease."

About M2GEN

M2GEN is an oncology-focused health informatics solutions company with the mission to help patients get access to the best treatments by leveraging clinical and molecular data to accelerate the discovery, development and delivery of tailored and more personalized therapies. M2GEN's approach is to transform cancer care through identifying the genome analysis of patient-derived tumor specimens, and translating new molecular insights combined with clinical insights into individual therapeutics and / or diagnostic tools. For more information, visitM2GEN.com.

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Whole Exome Sequencing Market Industry Size, Growth, Analysis and Forecast to 2026 Eurofins Scientific Group, F. Hoffmann-La Roche AG, Bio-Rad…

August 28th, 2020 2:55 am

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Waking up to fatigue in the veterinary clinic – American Veterinary Medical Association

August 28th, 2020 2:54 am

Much is known about compassion fatigue and its emotional toll on veterinary professionals. Less understood is how fatigue caused by insufficient sleep harms veterinarians, veterinary technicians, and veterinary assistants. Veterinary staff members may be tired after a demanding shift in the clinic, especially now with the added rigors of managing the coronavirus pandemic. And yet there appears to be little acknowledgement within the profession that such conditions are as much a danger to workplace safety as any infectious disease.

Sleep is a function of age, according to the National Institutes of Health, so while teens need at least nine hours of sleep each night, adults require between seven and eight hours. Fatigue occurs when a person doesnt sleep enough hours appropriate to their age group.

Signs of fatigue are hard to ignore. Lethargy. Irritability. Difficulty focusing. Chronic fatigue is a far more serious condition, described by the Mayo Clinic as unrelenting exhaustion that rest doesnt remedy, and may be a symptom of an underlying medical condition, including cancer or anemia.

Even the regular, run-of-the-mill fatigue attributable to working long hours and inadequate sleep is a health threat. A study cited by the nonprofit National Safety Council, which advocates for occupational safety, found that workers who reported less than five hours of sleep were three times as likely to be injured on the job as workers who reported seven or more hours of sleep.

Jenny Burke, NSC senior director of impairment practice, likened sleep deficiency to alcohol consumption. The effects of losing just two hours from an eight-hour sleep schedule are similar to drinking three beers. Most of us would not drink three beers and drive home, right? But were essentially doing that same thing when we take two hours away from a normal night of sleep, Burke said.

When NSC surveyed more than 500 human resource officers about recognizing signs of fatigue in staff members, approximately 50% reported employees had fallen asleep at work, 57% said employees missed work because they were tired, and a third reported workplace injuries and near misses caused by fatigued employees. These are just the incidents employers are noticing, said Burke, adding that fatigue costs the U.S. economy $400 billion annually.

So essential is sleep to physical and mental well-being that the Centers for Disease Control and Prevention classifies insomnia and other sleep disorders as a public health epidemic. We know theres a significant amount of the population that suffers from sleep apnea and doesnt even know it, Burke explained. Only 11% of actual sleep disorders are diagnosed and treated, so that leaves 89%roughly 70 million peoplewho have a sleep disorder and dont know it.

Little is known about fatigue and its impacts within the veterinary profession, which in recent years has turned its attention to improving the mental health and well-being of its members. Its worth noting that fatigue is linked to depression, diminished psychological and emotional health, and burnout. Human medicines experience in this area may be instructive to veterinarians, veterinary technicians, and veterinary assistants.

For starters, human health care professionals have been arguing over the effects of fatigue on physician performance and decision-making for more than three decades. In 1984, 18-year-old Libby Zion died in a New York state hospital as a consequence of mistakes made by overworked physicians. Five years later, the state passed legislation mandating that residents could not work in excess of 80 hours a week or for more than 24 consecutive hours. In 2003, the Accreditation Council for Graduate Medical Education adopted similar standards for U.S. medical schools.

I dont think clinics know what to do when they hire ER veterinarians, so they give them these crazy schedules, like overnights Friday, Saturday, and Sunday. Lets see how long you can do that.

Dr. Armelle de LaForcade, executive secretary, American Academy of Veterinary Emergency and Critical Care

The debate reignited in 2017 when the ACGME lifted the 16-hour cap for first-year residents, allowing them to work a 28-hour shift.

This past April, as the COVID-19 virus swept across the nation, the CDC stated fatigued and overworked health care workers can jeopardize their own health and safety, such as increasing their susceptibility to infectious diseases, needle sticks, work-related muscle injuries, and burnout, as well as committing patient care errors.

Then in May, the American Academy of Sleep Medicine warned that physician burnout is a serious and growing threat to the medical profession. While the prevalence is unknown, the academy cited recent estimates of physician burnout approaching 50% or more, with midcareer physicians at highest risk. Sleep deprivation due to shift-work schedules, high workload, long hours, sleep interruptions, and insufficient recovery sleep have been implicated in the genesis and perpetuation of burnout, the AASM stated.

It is the position of the American Academy of Sleep Medicine that a critical need exists to evaluate the roles of sleep disruption, sleep deprivation, and circadian misalignment in physician well-being and burnout. Such evaluation may pave the way for the development of effective countermeasures that promote healthy sleep, with the goal of reducing burnout and its negative impacts such as a shrinking physician workforce, poor physician health and functional outcomes, lower quality of care, and compromised patient safety.

Long hours and little downtime are also a challenge for fourth-year veterinary students in the clinical training phase of their education. In 2019, the Student AVMA updated its duty-hour guidelines with proposals that students work no more than 80 hours a week, work no more than 24 consecutive hours in continuous on-site duty, and be provided with breaks when they are on call. SAVMA does not have the authority to enforce these guidelines but encourages all AVMA Council on Educationaccredited institutions to consider following them.

Emergency and critical care is one sector of veterinary medicine where the effects of fatigue are the most acute. Despite high demand for veterinarians and veterinary technicians to staff emergency rooms and intensive care units, veterinary practices are struggling to retain staff members and fill these high-paying positions, said Dr. Armelle de LaForcade, executive secretary for the American Academy of Veterinary Emergency and Critical Care.

Reasons for the shortage vary, explained Dr. de LaForcade, a faculty member at the Cummings School of Veterinary Medicine at Tufts University, and include job-related stress, dealing with difficult clients, and a lack of professional development in veterinary emergency and critical care that doesnt require a residency.

Then you add to all of that having to work five overnights in a row. It takes you a day and a half to recover, but by then, youre back at work.

Staffing adjustments that account for these stressors are not commonplace in veterinary medicine, Dr. de LaForcade noted. Yet such a model is needed, one that allows staff members time to recover from overnight work. I dont think clinics know what to do when they hire ER veterinarians, so they give them these crazy schedules, like overnights Friday, Saturday, and Sunday, she said. Lets see how long you can do that. But clinics have nothing else to go by and believe that if you chose emergency medicine, then you must enjoy working nights.

Dr. de LaForcade wonders about the health costs of working second or third shift in the veterinary emergency sector. We dont know, she said. There are models in other professions that show the level of fatigue you get from working off-cycle from the rest of the world. Theres studies that show you are more prone to illness and other health issues.

Ideally, Dr. de LaForcade said, the ACVECC and Veterinary Emergency and Critical Care Society would partner with the AVMA or other veterinary organization on a study to identify a staffing plan that encourages longevity in veterinary emergency and critical care.

Most of us would not drink three beers and drive home, right? But were essentially doing that same thing when we take two hours away from a normal night of sleep.

Jenny Burke, senior director of impairment practice, National Safety Council

We need to look at practices that are retaining people and figure out what theyre doing differently, she said. I suspect theyre doing something like three days on, four days off, which is crazy compared to other veterinary fields, but the ER has so many stressors that that might be what you need.

Like their colleagues in emergency and critical care, large animal veterinarians are well acquainted with fatigue. The on-call shifts, hours on the road, and handling patients weighing hundreds of pounds can easily wear a person down.

Fatigue is a very real issue for equine practitioners because our clients appreciation is often measured by our availability to them, said Dr. Cara Rosenbaum, who works at a four-doctor referral hospital and ambulatory center in Wauconda, Illinois.

You may only be working 8 to 5, but then youre on the phone till 8 oclock at night answering client questions, she said.

Dr. Rosenbaum prepared herself as best she could for the demands of a career as an equine practitioner. As a student at Cornell University College of Veterinary Medicine, she was mindful of the importance of personal care and helped start a student wellness initiative at the veterinary college. After graduating in 2017, she interned at an equine hospital for a year before hiring on as an associate at the Wauconda practice the following year.

She quickly discovered there was more to learn, such as setting boundaries with clients and not being at their beck and call. Dr. Rosenbaum, who is a member of the American Association of Equine Practitioners Wellness Committee, says shes also respecting her sleep more.

I can tell the difference between being burned out and when Im fatigued, Dr. Rosenbaum said. When Im a little bit burnt out, if I get away from work and get on my kayak for two hours or get the dog to the dog park, I feel better. But when Im fatigued, I can do all the things I enjoy, and I still wake up the next morning not wanting to go back to work.

I think we forget that there is a physical part to being a large animal practitioner that contributes to fatigue, she continued. Ive had one shoulder surgery already, and if it starts hurting after having to haul a hundred pounds of equipment out of the truck each time for six appointments, it just exhausts you in a whole different way.

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Diversity, equity, inclusion efforts approved by Board, House – American Veterinary Medical Association

August 28th, 2020 2:54 am

The AVMA Board of Directors at its July 29 virtual meeting committed to retaining an outside diversity, equity, and inclusion consultant to help identify areas of greatest need, set priorities, and use resources most effectively. The Board of Directors also approved in concept the establishment of a profession- and industrywide commission to examine DEI issues affecting veterinary medicine.

Two days later, the AVMA House of Delegates approved a recommendation to the Board in support of the Boards commitments to make veterinary medicine more diverse, equitable, and inclusive. The move, during the regular annual session of the HOD held virtually July 30-31, caps off months of increasing interest and discussion in the veterinary profession on how to address systemic racism in light of the killings of George Floyd and other Black individuals earlier this year and the resulting protests and movement for social justice.

The recommendation asks the Board to implement the following actions:

The resolution passed with 92.3% support.

Earlier, the Board had approved hiring a DEI consultant. The goal was to define the consultants scope of work and identify candidates by Sept. 15. The Board also approved exploring the establishment of a professionwide commission to examine DEI issues affecting the profession. A consensus on the concept is expected by Oct. 1.

The outside expert will advise the AVMA on several suggested initiatives and projects, including many raised by the DEI affinity groups, led by the Multicultural VMA. These include areas of self-assessment, accessibility for all AVMA members to join and grow within AVMA leadership, accountability and transparency, gathering and analyzing member data, expanding membership and organizational commitments, and considering additional financial and structural commitments to improve DEI in veterinary medicine.

Dr. Janet Donlin, AVMA CEO, addressed the HOD at the beginning of the session.

This is your association, and we are committed to making sure everyone feels welcome, included, and an important part of this great profession, she said. Recent events have given us an opportunity to pause and reflect, to listen and to learn, and to consider what more we can do. We are committed to ensuring our profession is infused with an inclusive and diverse culture so everyone feels welcome, respected, and valued so we can best serve members, teams, communities, and clients.

Dr. Rena Carlson, outgoing AVMA Board chair, addressed the encounter on the Capitol steps between U.S. Reps. Alexandria Ocasio-Cortez, D-N.Y., and Ted Yoho, R-Fla., a veterinarian, during which Rep. Yoho reportedly directed a sexist remark toward Rep. Ocasio-Cortez.

Weve heard from many AVMA members, both women and men alike, about this matter. We hear you, and we are listening.

On Friday, July 24, the AVMA posted a statement on Facebook clearly reaffirming our values and what we stand for: that such behavior, whenever it happens, is inappropriate and unacceptable. We stressed our expectation that our memberswhatever their current role may beshould demonstrate professionalism to others at all times and uphold the dignity and respect of the veterinary profession. I understand that some are not satisfied with our statement because it doesnt directly condemn Rep. Yoho. However, we need to be clear on this as well: None of us were on those steps when this encounter occurred.

So were faced with two members of Congress offering very different characterizations of what happened on the Capitol steps. In the interest of fairness and without that firm knowledge of how the interaction transpired, we find it challenging to make a specific statement about Rep. Yohos behavior or words.

Dr. Carlson continued: For many of us, this type of language is far from new. We vividly remember our own personal experiences, from small sexist comments to those that hurt us to abuses that left us harmed and forever changed. When these encounters are reported, that memory and pain returns. The language reported in the news does not reflect what we stand for. Abusive language and misogynistic behavior have no place in veterinary medicine or society as a whole. The AVMA will continue to stand by our values and reiterate that derogatory and abusive language, when it happens, undermines our progress toward gender equity.

We must move forward together. Our profession is strong because its unified. What we can do together as a unified veterinary community is to learn from this and reflect on ways we should conduct ourselves and show respect to one another. And I firmly believe this lesson applies to all of usmyself, all of you, Representative Yoho, and everyone else who represents this great profession.

Also at the HOD meeting, Dr. Douglas Kratt, incoming AVMA president, made remarks on and introduced a video put together by 10 affinity organizations with a focus on diversity, equity, and inclusion: the Association of Asian Veterinary Medical Professionals, BlackDVM Network, Latinx VMA, Multicultural VMA, National Association for Black Veterinarians, Native American Veterinary Association, Pride Veterinary Medical Community, Pride Student VMC, Veterinarians as One for an Inclusive Community for Empowerment, and Womens Veterinary Leadership Development Initiative.

The video included testimonials from some of the hundreds who had submitted experiences of discrimination in the profession. Examples include a white professor at a veterinary college showing pictures of himself posing as a Mexican and another in blackface during a lecture. The person who recounted the latter incident reported it, but nothing happened. Another example was witnessing a veterinarian in the clinic telling a difficult pet, Dont make me George Floyd you.

Dr. Carol G. Ryan, Missouri delegate, said, I think a lot of times when we hear problems like this, if were not involved, we think they go away, but the other option is to face it head on, and thats what we need to do. If I dont hear things like that, I dont know theyre going on.

Dr. Christina V. Tran, president of the Multicultural VMA, told JAVMA News, The results from the AVMA HOD July 2020 session represent a significant shift in AVMAs previous prioritization of issues involving diversity, equity, and inclusion. We hope that forward progress will continue in a timely fashion and that these sustained efforts will be appropriately supported by the AVMA and made transparent to its membership and all stakeholders. There is more work to be done, and we anticipate broad participation and active collaboration between the AVMA and the veterinary community.

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From cats and dogs to lions and bears, this Redding veterinarian did a lot in 44 years – Record Searchlight

August 28th, 2020 2:54 am

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Dr. Ken Haynes is retiring as a veterinarian from the Dana Park Veterinary Hospital.(Photo: Mike Chapman/Record Searchlight)

Redding veterinarian Ken Haynes sawa variety of patients in his almost half-century-long career.

In addition to cats and dogs, the formerowner ofDana Park Veterinary Hospital treated birds, rabbits, ferrets, chinchillas, snakes, a beaver, bear cubs, mountain lion cubs and a Canadian lynx.

But mostly cats and dogs.

After 44 years in practice 33 of which were in Redding, Haynes, 68, retired from veterinary medicine on Wednesday.

He spent a lot of thattime emotionally supporting thebipeds who brought his patients to hisclinic, too. Pet ownersare very emotionally attached to their pets,"he said. "You help fix the pets, and you help fix the people. You get a two-fer.

Haynes recalled a particular case thatstymied him: TheTarantula from Torrance.I had no idea what to do for a sick tarantula. Im pretty sure I didnt have any tarantula classes in school.

The pet owner told Haynes the spiderwas listless and wasnt eating. Haynestook his word for it, called an entomologist for advice and treated the arachnid.

Otherwise his days at the office werepretty routine, he said.Ive got a few dog bite stories, but theyre better (told) in person. The stories come with hand signals.

Photos courtesy of the Facebook group Carr Fire Pet Rescue and Reunion. Redding Record Searchlight

Haynes sold his practice in December 2018. Since then, he opted to work part time at Dana Park.The workload wasnt much lighter than when he workedfull time,he said. It kind of squeezed five days of work into three days, but it gave me four days to recover.

In June 2019, he and his wifeChris Haynessold their house in Millville. Theymoved up to Dunsmuir with their dog and two cats.

I still love the job, but Im 68 years old, and my wife and I would like to take off and travel, and see what the other side looks like, he said. We just think its time (to retire).

The couple intended to vacation in Europe this summer, but canceled their plans due to risk of exposure during the coronavirus pandemic.

Instead, they will go to Colorado to do some fishing, Ken Haynes said. Well go back to some old places we used to go as a family, when I was a kid. Then Ill come back and get my second knee fixed. And then I dont know what Im going to do.

He will miss his former employees, he said. They made our hospital what it is today.

Haynes believes his patients and their people are in good hands. Were blessed with some very talented and competent veterinarians in this area, he said. Ive really enjoyed the relationship with my colleagues here in Redding.

Haynes said he wants to stay involved in veterinary medicine, eventually working part time again. But right now, Ill just relax and enjoy for a few months.

Ken and Chris Haynes moved from Manhattan Beach to Millville in 1987 with their two kids: Trevor (4) and Meaghan (2.5). Michael, now a third-year veterinary student in Sydney, Australia, was born in Redding in 1989.

While Haynes worked as a vetin Manhattan Beach, Redding was where he first owned his own practice. He bought Hilltop Veterinary Hospital in 1987 from retiring vet Charlie Clinkenbeard.

It wasnt long before hispractice outgrew the facility, he said. We built Dana Park Veterinary Hospital in 2002. We wanted a facility that was modern and designed to be comfortably for the employees and pets.

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When not in the office, Haynes made house calls to North State non-profits.

Up until 2015, he volunteered for Turtle Bay Exploration Park and its previous manifestation, the Carter House Museum.

One of his Turtle Bay patients was the parks rattlesnake, he said. They stay pretty healthythank goodness.

Haynes also treatedTimber the beaver, a park resident since2014. Hesbeen in for sutures twice. I think he gets himself cut on sticks.

Healso volunteered vet services and home care for Shasta Wildlife Rescue and Rehabilitation (SWRR) animals until about 2015. Among his SWRR patients were mountain lion cubs anda Canadian lynx.

The lynxwas found in Castle Crags State Park, wandering around a campground, he said. It was somebodys pet. The canines had been removed. She was declawed.

One patient who went home with Haynes: A12-pound bear cub, brought to a French Gulch residents home by their dog. "(It) couldnt stay at the clinic overnight," Haynes said. "It still needed to be bottle-fed."

More animal stories:

The Haynes' childrenhelped care for his SWRR patients includingorphaned squirrels, raccoons and other animals, Chris Haynes said. He (Ken) brought home a baby rat once. It kind of freaked me out, but the kids loved him. It was a wonderful life for the kids.

When the Carr and Camp firesdestroyed parts of Shasta and Butte counties in 2018, displacingtens of thousands of people and their pets,Haynes and his colleagues opened Dana Park's doors. They took inas manypets as they could, he said, until the facility was "overly-full with animals."

Two yearslater, Haynes hopes people will treat each other with the same compassion they showed each other during the fires. I would just like people to see the good in everyone and be kind, he said. Have grace.

Those who want to send Haynes a well wish can post on https://bit.ly/2Yilmxq, Chris Haynes said.

Jessica Skropanic is features reporter for the Record Searchlight/USA Today Network. She covers lifestyle andentertainment stories, andweekly arts featured.a.t.e. Followher on Twitter @RS_JSkropanicand on Facebook. Join Jessica in theGet Out! Nor Calrecreation Facebook group. To support and sustain this work, please subscribe today. Thank you.

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Amazon and Congo Basin Focus of New Emerging Infectious Disease Research Center – UC Davis

August 28th, 2020 2:54 am

The perimeters of the Amazon and Congo Basin forests are highly vulnerable to new and emerging infectious diseases. A new research center, the EpiCenter for Emerging Infectious Disease Intelligence, will focus on these two regions to advance understanding of how viruses emerge and spill over from wildlife to humans. The research aims to improve global preparedness and response for when such events occur.

This work is supported by the National Institutes of Healths National Institute of Allergy and Infectious Diseases, or NIAID, which awarded the University of California, Davis, School of Veterinary Medicine $8 million over five years to lead center activities.

The center will be funded under NIAID grant U01AI151814. The award is one of 10 research centers and a coordinating center made by NIAID to establish a network of Centers for Research in Emerging Infectious Diseases, or CREID, around the globe where emerging and re-emerging infectious disease outbreaks are likely to occur.

Multidisciplinary teams of investigators in the program will conduct pathogen/host surveillance, study pathogen transmission, pathogenesis and immunologic responses in the host, and will develop reagents and diagnostic assays for improved detection for important emerging pathogens and their vectors.

Our center brings together leading experts in emerging infectious disease surveillance with a One Health approach, said lead principal investigator Christine Kreuder Johnson, director of the EpiCenter for Disease Dynamics at the UC Davis One Health Institute. When the world emerges from the COVID-19 pandemic, we need to be sure to not let our guard down. We need to expand international collaborations in infectious disease research that integrate human, animal and environmental health.

Johnson said the center aims to help prevent the spread of emerging diseases by advancing our understanding of how environmental change brings about infectious diseases.

We hope this effort will facilitate new and exciting research in infectious disease with partners around the world," she added.

The center will initiate work to investigate emerging threats with implementing partners in Peru and Uganda. Research in these highly biodiverse regions offers the ability to examine the initial and subsequent stages of viral emergence, starting with animal-to-human spillover in forested areas, and progressing to human-to-human spread in areas along the forest periphery to more urbanized areas where epidemics can take off.

Team members consist of epidemiologists, virologists, entomologists and wildlife veterinarians who have pioneered techniques for surveillance at the animal-human interface. They have investigated Zika and dengue outbreaks in Latin America, Africa and Asia; ebolavirus outbreaks in Africa; and coronaviruses in Asia and Africa.

Surveillance and virus characterization will focus on emerging and re-emerging viral threats in the region, as well as on new viruses that could emerge to cause another pandemic.

The team will draw on their broad experience of collaborating with local and international partners to strengthen infectious disease surveillance and enable rapid responses to outbreaks.

You need look no further than COVID-19 to see why we should care about viral emergence that doesnt necessarily begin on U.S. soil, said co-principal investigator Lark Coffey, an associate professor in the Department of Pathology, Microbiology and Immunology at the UC Davis School of Veterinary Medicine. We know COVID-19 came from a nonhuman species in China and circumnavigated the globe in less than four months. With this project, one major contribution will be improving surveillance capacities in places that could benefit from enhanced detection in the environment and diagnoses in people.

The program will ramp up surveillance for emerging viral threats in these high priority regions, including pathogen X, to help prepare for future epidemics and potential pandemics. The team will focus on collecting and analyzing samples from bats, primates, mosquitoes, rodents and other animals that commonly share viral pathogens with humans. Team members will also work with local clinics and communities to optimize surveillance of human populations at high risk of zoonotic spillover.

This project will look specifically at zoonotic RNA viruses that are a major threat to people. That includes filoviruses like Ebola and Marburg, which can cause severe hemorrhagic disease, and arboviruses, like Zika and dengue that are spread by mosquito vectors.

Weve learned from COVID-19 that we need to be in the best position to prevent and halt pandemics, and Im proud that UC Davis continues to lead in this work, said Michael Lairmore, dean of the School of Veterinary Medicine. Our prior experience and One Health approach will ensure that we maximize the impact of the EpiCenter for Emerging Infectious Disease Intelligence.

The team includes well-established scientific partnerships fostered over more than a decade through the USAID PREDICT program, led by the UC Davis One Health Institute, along with the Uganda Viral Research Institute in Uganda and Pontificia Universidad Catlica in Peru. Activities will build on research implemented by co-principal investigator Tierra Smiley Evans on emerging pathogens in collaboration with the Gorilla Doctors program in Uganda, and longstanding research of mosquito-borne viruses in Peru, with co-principal investigators Chris Barker and Amy Morrison in the School of Veterinary Medicine at UC Davis, and Mariana Leguia at Pontificia Universidad Catlica del Per.

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Wildfires: The University Responds – UC Davis

August 28th, 2020 2:54 am

AT A GLANCE

From putting out the fires to caring for injured people and animals, to providing emergency housing for colleagues and their families UC Davis is responding to the horrific spate of wildfires in a big way.

As of this morning (Aug. 25), UC Davis had provided shelter for 15 households, a total of more than 40 people, faculty, staff and students and family members, most of them having had to evacuate, others who lost their homes.

The campus Fire Department as of Monday morning (Aug. 24) had contributed nearly 700 person-hours to firefighting efforts in Southern California and locally, for example, on the LNU Lightning Complex, where a UC Davis engine crew assisted on structure protection and backfiring operations around Vacaville and Winters last week.

Cal Fire reported this morning that the LNU complex had covered 352,913 acres across five counties Lake, Napa, Solano, Sonoma and Yolo and was 27 percent contained.

With fires of that size and hot spots all over the state, the UC Davis Fire Department has been going nonstop.

No sooner had a four-person crew on Brush Truck 34 returned to campus from the LNU complex Sunday night (Aug. 23), after having first worked on fires in the Angeles National Forest, than the truck was back on the road the next morning, returning to the LNU with a fresh crew, assigned to 24-hour shifts in Winters.

Monday, the UC Davis Medical Center was treating four people in intensive care for burns suffered in the Northern California wildfires and still keeping up with the coronavirus pandemic.

Read how UC Davis is responding to poor air quality, a result of the smoke from wildfires.

The School of Veterinary Medicine was taking care of four-legged patients: more than 1,000 in the field and more than two dozen in the Veterinary Medical Teaching Hospital. Officials said they are purposely trying to do most of their first aid in the field, because they are forced by the pandemic to limit hospital capacity.

Today, the Veterinary Emergency Response Team deployed a four-person team one faculty veterinarian and two resident veterinarians, and one student on a search and rescue operation in the Vacaville foothills. The team also performed wellness examinations on animals sheltered in place, treating 170 sheep, 100 cows and 40 pigs.

Read more about the veterinary schools response to the wildfires.

UC Davis put out the welcome mat Friday, offering short-term emergency housing for campus affiliates including faculty, staff and registered students and their families who had been impacted by evacuations or lost their homes due to the wildfires.

Student Housing and Dining Services, Real Estate Services and Human Resources Shared Service Organization, or SSO, are all involved in the project. SSO staff answered calls 12 hours day, Friday through Monday, and is now back to regular business hours (8 a.m.-5 p.m.), with UC Davis affiliates needing assistance still invited to call: 530-754-4772.

For campus affiliates who need somewhere to stay until evacuation orders are lifted and they can return home, the university is offering stays of up to five days. For campus affiliates who have lost their homes, the university can help explore options for longer-term housing solutions.

Stebbins Cold Canyon Reserve, a popular place to hike, is closed until further notice, to allow time for damage assessment and repairs.

UC Davis sustained losses, too, as the LNU Lightning Complex struck four of the universitys natural reserves: Quail Ridge, Stebbins Cold Canyon, Cahill Riparian Preserve and McLaughlin Natural Reserve, all in the vicinity of Lake Berryessa west of Davis.

With access limited, officials had not yet been able to assess the full extent of the damage to facilities and research projects. Shane Waddell, though, has seen some of what happened at Quail Ridge, where he is the reserve director. Fire claimed his home and eight tent cabins.

More posts and photos from last week.

His family evacuated last Tuesday night (Aug. 19), while he stayed behind to monitor the fire. As the flames drew closer, he decided to leave but not until he had told his neighbors on the Quail Ridge peninsula it was time to depart for their own safety.

Peggy Fiedler, executive director of the UC Natural Reserve System, said UC reserve managers and stewards up and down the state had been absolutely heroic in their efforts to save life and property.

Read more about what happened at the UC Davis reserves and four other UC reserves.

Follow Dateline UC Davis on Twitter.

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How To Know When Its Time To Say Goodbye To Your Dog – DogTime

August 28th, 2020 2:54 am

(Picture Credit: Getty Images)

The thought of our dogs dying is something that we pet parents have a lot of difficulty with. But the reality is that, unlike your children or anyone else youve helped raise and take care of, your dog will probably not outlive you.

Even more sobering, you may end up facing a difficult decision about when to end the life of this precious friend and family member. Some dogs do pass peacefully on their own, but in many cases, the will to survive keeps a dog going long past the point of experiencing good quality of life.

While recent advances in veterinary medicine are nothing short of amazing, remember that just because you can prolong your pets life doesnt mean its in your dogs best interest to do so.

Most of the factors around aging and death are beyond our control, but the one thing you are able to do for your dog is alleviate undue pain and suffering. Arguably, no other decision you make about your dog will be as difficult as the one to euthanize, but in so many cases, its the only humane option.

If theres ever a time to put your dogs welfare ahead of your own needs, this is it. While the idea of living without your beloved pet can be devastating, the thought of them suffering should feel even worse.

So in considering what to do, ask yourself the following questions:

(Picture Credit: Getty Images)

You may find that everyone feels free to tell you what to do, but the responsibility for this choice is yours. This can be more difficult if you have a significant other whos also attached to your dog, and you disagree about the next steps. However, it can still weigh heavily on a single person.

People often say, Youll know when its time. In many cases thats true, but not always. But remember that no matter what people tell you, choosing euthanasia is not playing God any more than providing medical treatment to save a life is.

Your veterinarian is trained to save lives. Thats what they do, and thats why you go to them. But all they can do is delay, not prevent. No vet should make you feel guilty for choosing not to pursue treatment, even if you can afford it.

If your vet is advising euthanasia and youre reluctant, closely examine your own motives and see if theyre for your benefit or the dogs.Most people believe its better to euthanize your dog a day too early rather than a day too late.

Euthanasia ensures that youll be able to be with your dog at the moment they pass, so theyre not alone. While you dont have to be present, keep in mind that dogs often look to their most beloved humans when theyre fearful, and it may be quite traumatic for your furry friend if youre not with them.

That said, it may be best for kids or those who cannot remain calm to not stick around, or else they may make a stressful situation even worse for a frightened dog and other humans who are present.

Before your dog gets to the point where euthanasia is a consideration, and youre still fairly calm, write a list of what gives them a good quality of life. Decide how many of those points they can be without in old age and still enjoy their life.

For example:

Thats seven points. How many points do you think your dog needs to enjoy life, even if theyre not in pain?

If you believe they can maintain quality of life with four of those seven, then you know it may be time to consider euthanasia if they lose the ability to keep three of those points.

Promise yourself that youll consider other factors, such as pain, the kind of senility that causes fear, and a lack of bodily function and control that may cancel out any items on the list.

Next, decide how much money you can afford to spend on veterinary care. Make a decision, write it down, and stick to your plan when your emotions are off the chart.

If your dog is suffering, then theyve already lost most of the joy that comes from being a dog. The emotions surrounding this decision are mixed and complicated. To do whats best for our dogs, we need to realistically assess the criteria without allowing emotion to overwhelm the decision-making process.

Have you ever decided when to end your dogs suffering? How did you make your decision? Let us know in the comments below.

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Leman Conference goes virtual with extensive speaker lineup – Feedstuffs

August 28th, 2020 2:54 am

The Allen D. Leman Swine Conference is an annual educational event for the global swine industry. It is internationally acclaimed for bringing science-driven solutions to the complex challenges facing the industry. Each year hundreds of participants from over 20 countries, including swine veterinarians and other professionals working in swine production and animal health management,attend the Leman Swine Conference. This year the conference is moving on-line and will take place Sept. 19-22.

The conference will include more keynote speakers than in previous years. The conference themes include markets, the impact of COVID and lessons learned, how to prepare for emerging diseases, and how to enhance your operation's value-added strategy.

"This year more than ever we felt strongly that we needed to have the Leman Conference. In May, we made the decision to move to an on-line format given the uncertainties we were anticipating due to COVID-19. If the Leman Conference was just presentations by experts, it would be relatively easy to create. The Leman Conference has always been much more, it is a gathering of a broad slice of the industry, from inputs to production to processing, with presentations that provoke further discussions, in hallways during the meeting and at gatherings beyond the meeting. It attempts to be always cognizant of the current circumstances of the industry, presenting diverse responses to challenges including novel diseases, labor shortages and now the disruptions in marketing challenges due to the various effects of Covid-19," saidprofessor Montse Torremorell, DVM, PhD, chair of the Leman Conference planning team in the University of Minnesota College of Veterinary Medicine's Department of Veterinary Population Medicine.

"Our aim is to create that online platform, welcoming not only our customary guests but a wider community of both presenters and participants who will have the opportunity to join us from their preferred location around the world. We hope that the flexibility of the platform we have chosen will allow an even broader participation in the conference and we hope that the community created by this conference will continue to meet the broadening of the swine industry. For once, we will have many talks translated to Spanish and Portuguese," Torremorell added.

From the 70+ talks and events we have prepared for you, here are the highlights:

Main program (Sept 21-22)

Keynotes:

Myrl Mortenson, David Wade, and Tara Donovan, Hanor

Michelle Kromm, Vice President of Animal Health and Welfare of Jennie-O and veterinarian for Hormel Foods

Gordon Spronk, Pipestone System and Clayton Johnson, Carthage Veterinary Services

Sessions:

Pre-conference program (Sept 19-20)

And dont miss the fun social events, engaging sessions and surprises!

For more information and registration, visit: https://ccaps.umn.edu/allen-d-leman-swine-conference

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Sneezes send dog to the owner’s rescue | Community | times-news.com – Cumberland Times-News

August 28th, 2020 2:54 am

DEAR DR. FOX: We have a 3-year-old female German shepherd/whippet mix who rushes to my husbands side every time he sneezes! She appears to be concerned about him when he sneezes. M.S., South Bend, Indiana

DEAR M.S.: Thanks for sharing how your dog responds to a sneeze. She may interpret the sound as a sign of distress many dogs are highly empathic.

Animals can get confused around humans making different sounds, some of which mimic the paralanguage of animal sounds indicating various emotional states and intentions. I know of dogs who bark when their human companion coughs or sneezes, possibly thinking the human is barking at something and giving a warning.

Many dogs give a deep sigh or two when they lie down to rest, much like we do; when I lie down and sigh next to our dog, she will often sigh in response. A baby crying in the crib often upsets dogs and cats living in the same home.

One sound in particular that can upset animals is the screaming of excited children, which I never allowed my children to engage in, especially around animals. Such high-pitched sounds can upset animals, since they are analogous to primal alarm signals. These sounds could make them more defensive and likely to snap, scratch or flee if the screamers get close.

There are reports of cats and dogs who have been stressed during this pandemic with children being at home all day. Many animals seek refuge away from these insensitive noisemakers, whose parents are either oblivious or think loud children are cute and spirited.

On a more humorous note, I am allergic to our local newspaper, and have several sneezes soon after I open the pages. The only one to complain is my wife. Our cat and dog ignore me!

Why many dogs are fearful

A recent essay was published in Scientific Reports by University of Helsinki researcher Dr. Jenni Puurunen and her colleagues, entitled Inadequate socialization, inactivity and urban living environment are associated with social fearfulness in pet dogs.

Data were collected on almost 6,000 companion dogs, varying in age from 2 months to 17 years, using a behavioral survey completed by their humans to assess how they responded to unfamiliar dogs and humans. It was found that fearful dogs had been socialized less during puppyhood, were small in body size, tended to be female and/or neutered and participated less frequently in training and other activities. They also found a novel association between the living environment of the dog and social fearfulness: Dogs living in a more urban environment were more likely afraid of dogs and strangers. There also were differences among breeds.

Another zoonotic disease to watch for

Vesicular stomatitis virus primarily affects horses, donkeys and mules, but cattle, hogs and people are also susceptible. The disease can spread like wildfire if flies that spread it arent controlled and animals that have it arent isolated.

An outbreak of vesicular stomatitis virus that reached Kansas in mid-June has now spread to 10 counties, according to the Kansas Department of Agriculture, and Missouri recorded its first case of the year this week. Cases have also been documented in Arizona, Nebraska, New Mexico, Oklahoma and Texas. Kansas Animal Health Commissioner Justin Smith urged horse owners to prioritize insect control to limit the further spread of disease. (Full story at agriculture.ks.gov)

Cat in U.K. recovers from coronavirus infection

The U.K.s Animal and Plant Health Agency confirmed a SARS-CoV-2 infection in a cat believed to have contracted the infection from its owners, who had confirmed cases of COVID-19, and both the cat and its owners have recovered. The cats preliminary diagnosis was feline herpes virus, but the cat was tested for infection with the novel coronavirus as part of a study. The data overall continue to suggest that cats may become infected by their owners if their owners have COVID-19, but there is no suggestion that they may transmit it to owners, said veterinarian James Wood, head of the University of Cambridges veterinary medicine department. (Full story at CNN.com)

Dogs trained to sniff coronavirus hit 94% success rate

It took about a week to train eight scent-detection dogs to differentiate saliva and mucus samples from people with and without COVID-19, say scientists at Germanys University of Veterinary Medicine Hanover. The dogs achieved about a 94% success rate when both types of samples were used in the pilot study. (Full story at dw.com)

Send all mail to animaldocfox@gmail.com or to Dr. Michael Fox in care of Andrews McMeel Syndication, 1130 Walnut St., Kansas City, MO 64106. The volume of mail received prohibits personal replies, but questions and comments of general interest will be discussed in future columns. Visit Dr. Foxs website at DrFoxOneHealth.com.

We are making critical coverage of the coronavirus available for free. Please consider subscribing so we can continue to bring you the latest news and information on this developing story.

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‘The Incredible Dr. Pol’ Reveals Why He Won’t Allow Some Clients To Appear on the Show – ‘We See That Way Too Much’ – Showbiz Cheat Sheet

August 28th, 2020 2:54 am

Now in its 17th season, Nat Geo Wilds The Incredible Dr. Pol only seems to get more popular with every season.

And its star, Dr. Jan Pol, 77, doesnt show any signs of slowing down, either, in all the farm visits and clients he sees on a daily basis.

The popular veterinarian will see anyone who comes through his clinics doors. And many of those clients agree in advance to appear on his reality show.

There are situations, however, where the animal doctor has had to refuse to allow certain clients to be on the program. Heres why.

RELATED:The Incredible Dr. Pol: Catch Up With Dr. Emily and Whats New for the Popular Veterinarian

The reality show started its current season in July 2020, and wraps up in September. The season after this one, the 18th season, will likely begin in the new year.

Speaking with Animal Radio in April 2020, Dr. Pol opened up about his experience as a country veterinarian.

Considering whether he preferred working with larger animals or smaller ones,the vet expressedthat I guess because I was born and raised on a dairy farm, I do like the bovine/equine part of it. But I do like the small animals because it allows us to do so much more.

The small animals they have more diseases, he explained. The horse can be a pet, but we have a lot of Amish here, and for them, the horse is a tool. And for the farmer the cow is a source of income.

RELATED:The Incredible Dr. Pol: When Dr. Pol Retires, Who Will Run His Veterinary Clinic?

A former crew member on the show opened up about the challenges of filming on the reality show. Particularly, he touched on filming around large farm animals.

Its nearly impossible to work, he wrote on a previous website of Dr. Pols. My hands are slippery wet and there is a constant stream of sunscreen-filled sweat running into my eyes. I can see sweat pouring from the faces of Dr. Brenda and the farmer . . .

One of the most incredible things about Dr. Brenda and Dr. Pol is their tenacity to perform veterinary medicine in any condition imaginable, he continued. They are relentless in their efforts, be it 105 degrees in the shade or -10 degrees in the snow. . . Their passion for animals and medicine is evident in every case they see. Its an honor and a privilege to work with these doctors on a daily basis.

While many of the doctors clients give their consent to have their case appear on the program, sometimes the vet has to decline their appearances. It turns out that not that many clients actually make it to the small screen, mostly because so many of the cases are repetitive and routine.

Probably one in 10 at the most, Dr. Pol in 2018 told Reality Blurred.

If a client wants to be filmed, Dr. Pol explained that their file is tagged so he knows when he walks in to the clients room, the film crew is going to be there. Then they put the extra lights on in the exam room, and we just walk in and do our work. The cameras always in the way because the rooms are not that big.

Other times, the doctor has to refuse to have the clients case broadcast, mostly to spare their feelings in difficult situations.

This happens mostly, Dr. Pol said, when people are not taking care of the animal, and we see that way too much. We dont want to say,Okay, look at this. We dont want anybody to look bad, to be honest with you. And sometimes, yes, you see it a little bit. But we dont dwell on it; we dont make it so obvious that it makes the owner feel bad or anything.

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Veterinarian residing in Truckee pleads guilty to tax evasion – South Tahoe Now

August 28th, 2020 2:54 am

A world-renown veterinarian living in Truckee leaded guilty today to one count of tax evasion.

Jack Ray Snyder, 63, was indicted in 2018 after it was alleged he failed to report significant income and filed false tax returns between 2012 and 2014. Besides the income discrepancy, Snyder was charged with deducting non-deductible personal expenses and overreporting his property taxes.

During these years Snyder was the Doctor of Veterinary Medicine at UC Davis's Center for Equine Health and was known around the world as a prominent equine surgeon. In 2014 the university sued the former professor for making more than $1 million in outside income while working for the school. The university claimed the money should have gone to them, and that Snyder went to great lengths to hide it.

In 2008, Snyder was the veterinarian for the Beijing Olympics.

According to the plea agreement, Snyder failed to report significant income for tax years 2011, 2012, 2013 and 2014. Each year, Snyder underreported his income to his tax preparer and took deductions for expenses that were not deductible business expenses. For the 2011 tax year, Snyder earned outside income as an equine veterinarian in addition to his salary as a professor at the University of California, Davis. He endorsed outside client payment checks to directly pay credit card bills. He failed to report $212,953 in income for the 2011 tax year. According to the plea agreement, the additional tax due for 2011, 2012, 2013, and 2014 tax years was $134,497.

This case is the product of an investigation by the Internal Revenue Service Criminal Investigation. Assistant U.S. Attorney Roger Yang is prosecuting the case.

Snyder is scheduled to be sentenced by U.S. District Judge William B. Shubb on Nov. 16. Snyder faces a maximum statutory penalty of five years in prison and a $100,000 fine. The actual sentence, however, will be determined at the discretion of the court after consideration of any applicable statutory factors and the Federal Sentencing Guidelines, which take into account a number of variables.

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Gene Therapy in Dogs Shows Progress for Krabbe Disease Treatment – Science Times

August 28th, 2020 2:54 am

An effective gene therapy for Krabbe disease treatment done in dogs might lead to a potential approach for the same disease in human children, a new study suggests.

A research team, led by the University of Pennsylvania, details an effective gene therapy procedure used in dogs to lasting effects, highlighting the potential for a similar approach to children. The methods and results of their studies are published in the latest Journal of Clinical Investigation (JCI).

(Photo: Steve Parsons - Pool/Getty Images)FRIMLEY, ENGLAND - MAY 22: Image released on May 27, A newborn baby in the maternity ward at Frimley Park Hospital in Surrey on May 22, 2020, in Frimley, United Kingdom.

Also known as infantile Krabbe disease or globoid cell leukodystrophy, Krabbe disease is a rare and often fatal condition that affects about one in 100,000 infants. Most children who are Krabbe disease carriers face death before they are two years old.

While the disease presents itself differently among asymptomatic infants, some of the most common Krabbe disease symptoms include irritability, limb stiffness, seizures, feeding, vomiting, and feeding difficulties. In its early stages, doctors often mistake Krabbe disease symptoms as those of cerebral palsy.

Krabbe disease falls under lysosomal storage diseasesan umbrella of about 50 rare and hereditary conditions caused by defects in lysosomal functions. Lysosomes are small containers of enzymes in cells. One gene, GALC, is responsible for encoding an enzyme that digests lipids in the body. For Krabbe disease carriers, a mutation in the GALC causes the buildup of lipids, leading to deformed development of the myelin sheath, which coats neurons, impairing nerve cell signaling.

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"This disease has no good therapy," said senior author Charles Vite from the University of Pennsylvania's School of Veterinary Medicine. He further explained that they have been examining the disease in dogs since the 1990s, noting that the shift to a novel gene therapy gave them the chance to treat the diseaseto a big effect on the nervous system.

An existing Krabbe disease treatment involves a bone marrow transplant within the first month after birth has been found to prevent symptoms in about 30 percent of infants. But the procedure is not without risks, with Vite stressing the need for a new treatment in a press release from the University of Pennsylvania.

Canines that are Krabbe disease carriers are from Penn Vet's Referral Center for Animal Models of Human Genetic Disease, allowing the investigation of new therapies. To start dampening the symptoms of the condition, researchers identified the introduction of a healthy GALC gene to the canine brain as an important part of the procedure.

To achieve the requirement, they used a particular vector, the AAV9 vector, to deliver the healthy GALC gene. The vector in the study was previously used in experimental gene therapies for neurological diseases, noting that it seems to be the best candidate for approval from the Food and Drug Administration (FDA).

Another consideration in the study is the location for gene delivery. Researchers decided to send the gene by injecting it through the spinal fluid located at the back of the head. Vite notes that the spinal fluid offers the optimal delivery route of the gene to the brain.

RELATED: Is Coronavirus Attacking the Central Nervous System?

Canine participants that received that high-dose therapy displayed health myelination in the brain cells. Furthermore, gene therapy also had a positive effect on myelin development, even for parts of the peripheral nervous system.

"That was a huge surprise for us... that injecting a gene therapy in the spinal fluid can positively affect both the central and the peripheral nervous system was really exciting," Vite commented.

Check out more news and information onMedicine and Healthon Science Times.

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