StemCell Therapy

With the current corona virus pandemic in the United States and world wide, there are many scientists working very diligently to come up with an effective vaccine to reduce the significant healthcare impact of this virus. They are also evaluating and working on the various treatments options for the many people who have been infected with this virus. Therefore, I believe it is timely at this time to again review the importance of our human immune system and vaccines that can provide herd immunity.

Human Immune System The overall function of our human immune system is to prevent or limit infection. The primary job of our immune system is to distinguish between our normal, healthy cells and possible other dangerous cells, such as viruses and bacteria that may come into our blood stream. Our immune system is always on duty to look for and recognize these possible infectious viruses and bacteria. The immune system looks closely at these potentially infectious cells to do all it can to prevent us from getting an infection.

Know that we rely on our immune system every day to help us fight off infections and keep us healthy. Our immune system contains numerous cell types that either circulate throughout the body or reside in our particular body tissues. Each cell type plays a unique role, with different ways of performing their function to fight off infections. Further, many world wide medical and scientific researchers are working diligently at this time to develop a vaccine to effectively prevent the corona virus.

Vaccines When we receive a vaccine in our body, our powerful human immune system notes that this is a foreign potentially dangerous substance and promptly begins to make antibodies to fight it off. Here is the true positive impact of vaccines on USA health today. Our federal government reports that because of USA children receiving the recommended childhood immunizations, around 20 million illnesses and more than 40,000 deaths are prevented, resulting in approximately $70 billion in health care savings. Vaccinations are effective primarily due to two factors. First, once a person is immunized against a specific disease producing organism, the rate of that disease, as well as its associated asymptomatic carrier state, is decreased. Second, when a large population is immunized, unvaccinated individuals may also benefit from a reduced risk of exposure to these disease producing organisms.

Herd Immunity Herd immunity is a form of indirect protection from infectious disease that occurs when a sufficient percentage of a population has become immune to an infection, whether from vaccination or from previous infections, thereby reducing the likelihood of infection for individuals who lack immunity. Following is a brief review of the two ways we can receive herd immunity.

So, how do we achieve herd immunity? There are two ways this can happen. 1. We can develop resistance naturally. When our body is exposed to a virus or bacteria, it makes antibodies to fight off the infection. When we recover, our body keeps these antibodies, and then our body will defend against another infection of this type. 2. Vaccines will also build herd immunity. They make your body think a virus or a bacteria has infected it. You dont get sick, but your immune system still makes protective antibodies. The next time your body meets that bacteria or virus, it is ready to fight it off. Perhaps the greatest example the effectiveness of vaccines is the fact that the Salk vaccine essentially eliminated polio in the United States.

EDITORS NOTE: Dr. Jim Surrell is the author of The ABCs For Success In All We Do and the SOS (Stop Only Sugar) Diet books.Contact Dr. Surrell by email at sosdietdoc@gmail.com.

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Talk with the Doc: The human immune system and 'herd' immunity - Marquette Mining Journal

When you think about protein, you probablyworry about getting enough to repair muscle tissue after a tough workout, to help your body build lean, strong muscles and lose weight while boosting your natural calorie burn. All that's true but protein also serves another critical function in the body: It helps power your immune system, stoking the cells that you need to fight off infection, both bacterial and viral, and keep your guard up against illness of all kinds.

Protein plays an important role in powering your body'sT-cells, the agentsthat go out and attack opportunistic invaders that can get into your bloodstream and cause infection, and if you lack adequate protein intake, it can impair immune reaction, studies have found. Adiet low in protein leavesyou open to fatigue, weakness, and low immune response, all the more reason you need to get your essential amino acids from the food you eat (which is better than supplements). Meanwhile, your body is just as happy to get its full complement of protein from plants.

Proteins make up the framework of your cells, including the cells of the immune system and just about every other. But you don't have to worry if you're eating mostly plant-based foods, since the source of protein is less important than getting a full array of essential amino acids, specifically the 9 ones your body can't make enough of on its own.

In rare cases of protein deficiency (very seldom in a healthy US population other than those patients being treated with chemo), your immune system can stall, but the more frequent scenario of eating too much protein can also dampen downyour immune system by overtaxing your kidneys, which can't flush it fast enough. Americans, while obsessed with eating enough protein, are likely to eattoo much, according to experts. On average weeat up to twice as much protein as they need, about 100 grams a day when 60 is closer to the average that most people should get. The latest studies show thatthe right amount of protein is critical for your immune system to be healthiest.

In hospitals where patients lack appetite and treatments can zap their immunity, especially when someone is on chemotherapy for cancer, they are often given arginine, an amino acid that contains the most nitrogen of any, and has been shown to help boost immunity and speed up healing, according to the latest research.Another amino acid, glutamine, travels in your blood cells to offer your intestinal cells curative effects, which can prevent microbial contamination from the food you eat. But for most of us, supplements are not the answer, a healthy diet with a variety of vegetables, grains, legumes, fruits, nuts, and seeds will do it.

"Most healthy adults should aim to get around .8 to 1.2 grams of protein per kilogram of body weight per day, or roughly 55 to 80 grams of protein for a 150 lb adult," saysKatie Mikus, Manager of Scientific Affairs for Glanbia,which makes a plant-basedsupplementcalled Gold Standard 100% Plant with 24 grams of protein and4 Grams of Naturally Occurring Glutamine. For the right amount of protein for your size, activity level, age, and gender, check out this handy calculator here."Those looking to build or maintain muscle mass may wish to consume as much as 2.2 grams of protein per kilogram body weight per day," she adds.

When it comes to protein quality, look for protein sources that are easily digested and contain all 9 essential amino acids. Essential amino acids are those that must be consumed through whole foods or supplements because the body cannot make sufficient quantities to meet demand.

The richest plant sources of proteins tend to be legumes like soybeans, chickpeas, and beans and whole grains like quinoa and amaranth as well as certain vegetables, nuts, seeds and fruit. For a complete list of the best sources of plant-based proteins, see the 20 top vegetables for protein, compiled by The Beet.

Many plant-based proteins are "incomplete,"meaning they lack one or more of the 9 essential amino acids your body can't make on its own. "Complimentary incomplete plant proteins can be combined to create a complete protein. For example, grains tend to be low in lysine and high in methionine and cysteine, whereas legumes tend to be high in lysine and low in methionine and cysteine," Mikus explains. "So combining rice and beans will give you a complete protein, or peanut butter and whole wheat bread are examples of complementary proteins that make a complete protein when eaten together."

Complimentary plant proteins dont necessarily have to be eaten together as long as you consume protein from a variety of plant sources throughout the day. For more on how to get your complete proteins, see The Beet's story on perfect plant-based proteins.

But rather than worry about getting all 9 essential amino acids at one sitting, simply eat a varied plant-based diet throughout the day and your body can take care of the rest. One easy way is to combinerice and beans,but you can also just make sure to get a variety ofplant-based foodsand be sure to include legumes like chickpeas in your lunch salad. You don't have to eat all the building blocks at once, as nutritionists once thought since your body has the extraordinary ability to assemble them into the necessary proteins to operate at peak performance.

Eating to support a healthy immune system is as simple as following the basic principles of healthy eating. Your best bet: Consume a variety of foods and try to fill half your plate with fruits and vegetables, and make at least half of the grains you eat whole grains. Try to limit processed foods, excess sodium, added sugars, and saturated fats which drive up inflammation. In addition to proper nutrition and hydration, getting adequate sleep, minimizing and managing stress, and incorporating regular physical activity are all healthy lifestyle choices that help support a healthy immune system.

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Eat Protein to Boost Your Immune System. Here's How Much You Need - The Beet

Scientists have used artificial intelligence to reveal an aggressive form of pancreatic cancer that is more likely to respond to immunotherapy, in the most extensive analysis of the immune landscape of these tumours to date.

Pancreatic neuroendocrine cancer starts in cells that produce hormones such as insulin. Once it spreads, only one in four people will survive for more than five years, and new treatment options are desperately needed.

The new study found that a particularly aggressive type of these tumours can evade immune attack by hijacking the immune systems response to viral infections, and reveals possible targets for immunotherapy for this rare, hard-to-treat form of pancreatic cancer.

Next, the researchers plan to translate their findings into new clinical trials to test the possible benefit of immunotherapies in those patients most likely to respond.

Scientists at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust, working with colleagues at the University and Hospital Trust of Verona, Italy, used AI and genetic analysis to study 207 tumour samples from patients with pancreatic neuroendocrine tumours for the levels of 600 immune-related genes.

Comparing four separate forms of the disease, they found that samples of the most aggressive form, known as metastases-like primary tumours, saw changes in activity of 74 immune-related genes, compared with changes in only 12 immune system genes in the more benign insulinoma-like tumours.

The study was published in the journal Gut today (Tuesday), and was funded by the NIHR Biomedical Research Centre at The Royal Marsden and The Institute of Cancer Research (ICR), the ICR itself, and by Italian charities including the AIRC Foundation for Cancer Research.

The scientists found that 83 per cent of aggressive, metastatic-like tumours contained particularly high levels of a gene called TLR3, part of a damage-alert system that mimics the infection response triggered by viruses, drawing immune cells to the tumour.

This damage response is related to a form of programmed cell death that occurs when theres not enough oxygen which can happen inside metastatic-like tumours, which tend to be larger in size.

The researchers believe that by hijacking the damage response through TLR3 which helps flag tumour cells to the immune system cancer cells can escape from the immune system, leading to the tumours ability to grow and evolve.

The ICR, a charity and research institute, is raising the final 2 million for its revolutionary new Centre for Cancer Drug Discovery, dedicated to overcoming cancers ability to evolve resistance to treatment.

Importantly, the ICR team also studied the presence of known targets for existing immunotherapies in all four kinds of pancreatic neuroendocrine tumours.

They found that the most aggressive type had the highest levels of an immune marker known as PD-L1, which suggests they can be targeted with immunotherapies designed to take the brakes off the immune system so it can attack tumour cells, known as checkpoint inhibitors.

Immunotherapy treatments have been shown to work very well in some tumour types but they dont work for everyone and have only shown modest benefits in this form of pancreatic cancer, so it is important to be able to identify the patients who are most likely to benefit from immunotherapy.

The researchers now hope their results will lead to clinical trials to test the benefit of immunotherapies, either alone or in combination with other treatments, for patients with the metastatic-like form of pancreatic neuroendocrine tumours.

Dr Anguraj Sadanandam, Team Leader in Systems and Precision Cancer Medicine at The Institute of Cancer Research, London, said:

Our new study offers an important basis from which to start developing new treatment strategies for a rare form of cancer, which starts in the hormone-producing cells of the pancreas.

We found that there is a complex interplay between cancer and immune cells in the most aggressive type of pancreatic neuroendocrine tumours, which suggests immunotherapy could work for patients with this form of the disease.

Our findings could help to pick out those patients most likely to benefit from immunotherapy and were keen to translate our work into clinical trials to test the benefit of different immunotherapeutic strategies to tackle this hard-to-treat form of pancreatic cancer.

Professor Paul Workman, Chief Executive of The Institute of Cancer Research, London, said:

Pancreatic cancers have some of the poorest survival rates so its hugely encouraging to see such an extensive study of the immune landscape of a rare form of pancreatic cancer, looking at the underlying biology to inform the best way forward in treating the disease.

Its fascinating to see a mechanism unveiled by which these tumours develop the activity of a highly distinct set of immune-related genes, as this could not only underlie the immune escape of these tumours, but also feed into their ability to evolve one of the biggest challenges in cancer research and treatment today.

Immunotherapy has transformed the outlook for a range of different cancer types, and I look forward to seeing these new findings progress to clinical trials, which might lead to a more personalised way of treating people with pancreatic neuroendocrine tumours.

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Hard-to-treat pancreatic cancer hijacks immune system and could be targeted with immunotherapies - PharmiWeb.com

Magnetude Jewelry Fall 2020

MT AIRY, Md. (PRWEB) September 01, 2020

In a fall like no other, Magnetude Jewelry finds itself with the right product at the right time. Interchangeable fashion jewelry pendants and necklaces that allow one to change the stone based on mood and occasion is already a hot fashion trend, but in a year where everybody is looking for strategies to boost and improve the immune system, Magnetudes second key ingredient is about what the products are made of: Neodymium magnets.

Most people dont realize that their electrical energy is diminished by EMFs and can decrease their immunity, explains Magnetude co-founder Dr. Tracey Diner, DC. Wearing Magnetude Jewelry along with other healthy regiments like vitamins, good diet, and exercise, help us build up a stronger resistance to viruses and germs.

EMFs come from many sources in this high-tech age, including cell phones, Wifi, cell towers, and other electronic activity. Dr. Diner, a wellness doctor, and her partner Candice Loren, a noted artist and jewelry designer, started this company to pursue their joint passions for unique design and better health.

Magnetude Jewelry incorporates the most powerful healthy Neodymium magnets, energy elements of infrared, negative ion, and germanium in all of their interchangeable necklaces, bracelets, and earrings. These energy frequencies help to replenish the cellular function that EMFs destroy. With the fall flu season about to start and the expected second wave of COVID-19 on the horizon, innovative ways to stay healthier are at a premium.

Magnetude Jewelry should be worn all the time, so it has been designed with thousands of combinations to match any clothing the wearer chooses. There are product lines for men and pets, and this month Dr. Diner says she is launching a childrens line because children are at higher risk from EMFs, absorbing up to 10 times that of adults.

For further information about Magnetude Jewelry and the science behind it, visit http://www.MagnetudeJewelry.com.

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FALL 2020 - Magnetude Jewelry Fashion Line Supports the Immune System - PR Web

Wells: Is there any downside of giving people plasma, even if you dont know if its going to be specifically helpful to them?

Hamblin: There theoretically shouldnt be, but there could, and that is the reason that you dont just authorize these things, that you have an FDA to make sure that something is safe and effective ...

Kola: It seems like people have antibodies within three months of them having COVID-19. And I definitely had antibodies back in May when I was given an antibody test, but then, given the news out of Hong Kong, it looks like those antibodies might wane over time? When I imagine the plasma, am I imagining blood that has actual antibodies in it, or does it have the memory of how to make antibodies? Whats actually in the plasma?

Hamblin: Thats a great question Youre just getting the antibodies themselves. The act of producing them will involve the white blood cells that should be taken out of plasma

Wells: Theyre the things that make the antibodies ... and that do have the memory of how to make them?

Hamblin: Right When you transmit plasma, youre not teaching someone to make antibodies. Thats what happens by exposing them to the virus. Thats vaccination. Its called passive immunization, where you temporarily have these antibodies until your blood clears them out. Theyre gone, and youd theoretically have to get another transfusion.

Kola: So there would be the possibility that, having had COVID-19 in March, and maybe being called upon to donate plasma in October, my blood might not have the antibodies anymore that it had in May.

Hamblin: Yeah, that remains possible.

Kola: Wow.

Wells: Is that upsetting?

Kola: I think its like much to do with COVID: Just one of the sort of confusing complexities of it is that I know that I had the antibodies at one point. I cant know for sure that I have them now without another antibody test. And being someone who had it relatively early, my experience of the virus is myself and everyone around me learning about it almost in real time ...

Hamblin: Well, if it helps reassureI guess Katherine can explain the immunology here, because we had a whole episode on thisbut there is more to your bodys memory than just the presence of antibodies themselves. There are immune-messaging pathways such that even if you lost your antibodies, its possible that your body might be able to kind of quickly make new ones and call them back and have other ways of fighting off this virus so that, if you are reinfected, it is not so bad, even if you dont actively have the antibodies.

Kola: Can you explain how people like me who had COVID-19 and are hopeful about immunity should interpret the information from Hong Kong, because that was obviously, on the face of it, quite scary for people whove had an experience of COVID that they wouldnt wish to go through again.

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Listen: Plasma and Immunity - The Atlantic

A new test that provides information on the immune response to the novel coronavirus in patients who need to take immunosuppressive drugs has shown that these patients can achieve a good immune response to SARS-CoV-2 despite immunosuppression.

A research team from the University Hospital at Ruhr-Universitt Bochum (RUB Bochum, Germany) has developed the test which can be used to adapt immunosuppressive therapy individually during a COVID-19 infection, such as following an organ transplantation. The test is of great clinical relevance for transplant patients as it provides information that goes far beyond a pure antibody test.

Transplant patients are affected in several ways: in addition to the chronic illness that led to organ failure and subsequent transplantation, transplant patients need to take medications that suppress the defenses of their own immune system. Chronically ill patients with impaired immune defenses have an increased risk of suffering from a severe COVID-19 infection. It was previously unknown whether patients could develop a sufficient reaction against the new coronavirus under the influence of immunosuppressive drugs.

With the help of the test, the team demonstrated that transplant patients are very capable of achieving a good immune response despite immunosuppression. In addition to high antibody titres, large quantities of T lymphocytes, which are responsible for killing infected cells, were found in the current case study.

Until now, it has not been known whether our transplant patients are capable of forming a sufficient immune response to the new coronavirus, said Professor Timm Westhoff, Director of Medical Clinic I at Marien Hospital Herne, who led the team of researchers. The data obtained help us to deal with immunosuppression during the current pandemic. The test allows us to individually adjust immunosuppression when a patient is suffering from COVID-19.

Related Links:Ruhr-Universitt Bochum

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New COVID-19 Test Shows Patients with Suppressed Immune Systems Can Also Achieve Good Immune Response to SARS-CoV-2 - HospiMedica

How do you strengthen the immune system, the bodys natural defense against disease and infections, is a very common question. The answers often include regular exercise, an adequate amount of sleep, no smoking or excessive alcohol drinking, and of course, a healthy diet.

However, some of these are probably hard to implement during a pandemic. Stress levels are high and most people are simply trying to manage each day as best as they can. Spending a lot of time planning meals that have all food groups is practically impossible, so individual items that have copious amounts of vitamins, minerals, and antioxidants all in one may come in handy.

24/7 Tempo used the U.S. Department of Agriculture site to determine fall foods, and consulted a clinical nutritionist to identify the best fall superfoods that may help boost immunity.

Eating the right foods is not rocket science, and superfoods is not a scientific term. Its a marketing term used to describe foods that are nutritionally dense, although often there are also misconceptions about which fruits and vegetables fit that description. Not all foods are created equal, and you only think some foods are healthy when, in reality, they wreak havoc on your body.

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29 Fall Superfoods That Will Boost Your Immune System - MSN Money

Thursday, August 27, 2020

In this episode, Foley PartnersJudy WaltzandAntoinette Konskitalk withEdward Abrahams, the President of the Personalized Medicine Coalition, to discuss the issues facing personalized medicine and how the concepts underpinning the field may be applied to diagnose and treat COVID-19.

We encourage you to listen to thepodcast in its entirety.

Following is a transcript of this podcast. Please feel free to download aPDF version here.

Please note that theinterview copy below is not verbatim. We do our best to provide you with a summary of what is covered during the show. Thank you for your consideration, and enjoy the show!

Personalized or precision medicine is the field of medicine that finds the best treatment for each patient at the right time. Physicians use diagnostic tests, medical history, circumstances, and values, as well as information from prior patient therapies, to prevent disease and develop targeted therapies that can expedite a patient's treatment and recovery.

The Personalized Medicine Coalition, or PMC, is an advocacy and educational group that represents innovators, scientists, patients, providers, and payers to promote the understanding and adoption of personalized medicine concepts, services, and products. Dr. Edward Abrahams is the president of the PMC and has charted its growth from its original 18 founding members in 2004 to more than 200 members today.

I am pleased to have Ed as our guest to explore issues facing personalized medicine and how its concepts and emerging research may be applied to diagnose and treat COVID-19. Ed, thank you so much for being with us here today. Did I hit the mark on precision medicine? Is there anything you would like to add by way of introduction to yourself or the PMC?

I think you have defined personalized medicine very well indeed. Let me begin by noting, as you just did, that I have never met a patient who did not prefer getting the right medication the first time, rather than going through a process of trial and error because the right diagnosis could not be made in advance of selecting the right therapy.

The good news is that we have many more molecular diagnostics today to target the right treatments to the right patients at the right time, as is often said. But personalized medicine also promises lower costs for systems that incorporate the tests and treatments underpinning the field into their clinical work streams. This is very important. By becoming more efficient with targeted therapeutics and avoiding costly interventions that don't work, personalized medicine can help these systems save money, and, at the same time, provide better outcomes for individual patients.

In other words, and this is terribly important in today's context of constricted resources for health care, with personalized medicine, we can enjoy the benefits of innovation and reduce costs. But we have to be smart about how we develop these opportunities. At present, we have only anecdotal evidence that personalized medicine can deliver both clinical and economic benefits, which is why PMC is doing the research to demonstrate that even if individual therapies come with high price tags, as many in fact do, they can and will produce cost savings if we target them to only those patients who will benefit.

That, in brief, is the real promise of personalized medicine. We believe personalized medicine can provide tremendous value, not only to patients, but also to the systems and countries that in fact have the courage to implement it.

Thank you so much for that explanation and background on personalized medicine and how it is being used today to treat and prevent disease. Ed, for me, one of the highlights of the year is the publication of PMC's annual report that summarizes the key advances the industry has made over the past year. When will the 2020 edition be released, and can you give us a preview of what to expect?

Within the next eight weeks, the Personalized Medicine Coalition will publish the sixth edition ofThe Personalized Medicine Report. We used to call itThe Case for Personalized Medicine, but we now believe that the case has been made.

The report is our effort to define the field by explaining personalized medicine's opportunity, documenting its status, and discussing the challenges it faces. It's a widely read report that is written for laymen, particularly policymakers at federal agencies and on Capitol Hill.

The sixth edition will, for example, show that in 2008, there were only five personalized medicines, which we define as therapeutics with biomarker strategies on their labels, on the market. Today, there are over 250, so you can see there's been enormous progress over these past 10 years or so.

While most of these products are in oncology, we have also seen progress in other indications as well, including cardiovascular illness, depression, and especially rare diseases. The report will also show that today there are 75,000 genetic testing products on the market, up from fewer than 66,000 in 2016. In other words, this is an exploding field.

Also new in this report are discussions of how advanced analytics, artificial intelligence, and machine learning are yielding new insights about how other biological and environmental factors, in addition to genetics, influence a patient's disease risk and response to various treatments, thus opening the door to preventive medicine, one of personalized medicines most important if as yet unrealized promises.

The report documents how, by targeting effective treatments to those patients who benefit, personalized medicine can achieve key goals for patients and health systems. It can shift the emphasis in medicine from reaction to prevention with emerging technologies like liquid biopsies, which may be able to detect cancer before any symptoms occur. This is tremendously important and a great promise. It may reduce trial-and-error prescribing, which patients would absolutely love.

Personalized medicine can also cut the number of adverse drug reactions, which right now are the third or fourth largest cause of death in the United States. It can use cell-based or gene therapy to replace or circumvent molecular pathways associated with disease, thereby offering cures where none had existed before. It can reveal additional targeted uses for medicines and drug candidates. It will obviously increase patient adherence to treatment, as patients will be more likely to stay on medications that don't have dangerous side effects, for example.

Personalized medicine will also reduce high-risk invasive procedures, which it already has done in say, kidney transplants, for example. It will help move patient-physician engagement toward patient-centered care. And finally, as I mentioned, it could and should reduce the overall cost of health care.

The report makes the argument that outstanding challenges in regulation, reimbursement, and clinical adoption slow our efforts to capitalize on advances made possible by personalizing treatments. Overcoming these obstacles, as we write, will require a collaborative effort to keep up with the pace of progress in science and technology. And this is in fact the overall mission of the Personalized Medicine Coalition.

At the end of the dayand you mentioned this a bit in your commentsfor personalized medicine to be a success and available to patients, it has to be adopted by the clinicians. How does that happen, and are there obstacles to that success?

This is a key thrust of the Personalized Medicine Coalition because we are learning that clinical adoption is a much slower process than patients want and expect. For example, PMC will publish a study this week documenting that medically appropriate genomic testing is quite inconsistent across the United States.

That means, for example, that some patients in cancer are not getting available treatments they need. The study shows that coverage and reimbursement strategies are not the only barriers to personalized medicine, as you might expect. Other barriers include lack of awareness among providers and patients, not to mention socioeconomic factors, including distance and access issues.

In medicine, it doesn't necessarily follow that if you build it, they will come. There are many mediators along the way from discovery and development to adoption. We also know from another PMC-commissioned study of the value of genomic testing in cancer care, for example, that many patients who are eligible for effective targeted therapies, as determined by genomic sequencing of their tumor, still do not receive the best treatment option based on the results.

This practice gap can be attributed to the limitations in the availability and interpretation of test results, sample processing constraints, limited access to targeted therapies, and especially lagging awareness of the rapidly evolving field of personalized medicine among physicians and other providers.

We demonstrate in this study that if all patients who were eligible to receive a targeted treatment actually received it, the cost-effectiveness of genomic sequencing, which is sometimes alleged to be too high, would significantly improve. In short, along with public policy, we know that the downstream issues focused on clinical adoption are extremely important and must be addressed.

We are in a continuing debate with respect to drug pricing in the United States. How does that debate impact the future of personalized medicine and how would you address or make some recommendations as to how we price our drugs?

That's a very important question because as you know, the drug pricing debate has gripped public attention. But we are not considering all ramifications. The debate has particular implications for the development of personalized medicines, which tend to be more expensive but may together have a positive impact on the health care system and on overall costs.

We have to ensure that innovative products remain accessible, including to those who cannot afford them. But we also have to be careful not to remove the incentives to discover and develop those products in the first place, which I am afraid that price controlsno matter how they are implementedwould do. That is to say, they would stifle innovation. Drug development is a risky business. There are no guarantees. If we move or decrease the financial incentive to find new cures to unmet medical needs, it follows that we're going to see fewer interventions.

Late last month, President Trump issued an executive order to tie the prices paid for physician-administered drugs, many of which are personalized medicines, to those that are paid in other countries. That may be politically popular because those other countries pay less. But the policy, if implemented, will have disastrous unintended consequences for the development of say, new cell-based therapies, gene therapies, and targeted medicines that are only now reshaping health care in ways no one thought possible ten years ago.

This is so because there are incentives in place to encourage the development of groundbreaking therapies. It's important to understand that when a pharmaceutical company invests in, say, finding a one-shot cure for spinal muscular atrophya rare and debilitating disorder that affects fewer than 25,000 people in the United Statesit does so without any guarantee of success, and it does so also with very high up-front costs that must be recovered. If the company that develops the cure cannot get a return on its investment, it's unlikely to take these big risks upon which patients depend. Long story short, patients will suffer and the costs of providing carenot curesfor those patients will remain higher than they could be.

I'd like your opinion on a topic of current urgent and global concern. Today, we are challenged medically and economically with the COVID-19 pandemic. How have the principles of personalized medicine been applied to diagnosing and treating COVID-19?

I actually believe that the principles of personalized medicine that emphasize stratified responses, even when it comes to public health, have significant implications for diagnosing and treating COVID-19. Those principles, I believe, should inform future interventions to stem this terrible pandemic that has already killed over 170,000 people in the United States alone.

I don't think these principles are being adequately considered as part of the debate. PMC looks forward to introducing those principles, because they're so very important if we're going to effectively address this pandemic.

First, we have been very slow to develop and deploy real-time diagnosticsthe backbone of personalized medicine. These diagnostics give us the tools to determine who is at risk, so we don't have to put in place one-size-fits-all public health responses, including closing down whole economies, when that might not be necessary if we knew who had the disease or who was likely to get the disease.

To date, we have not been able to target long-term prevention and treatment plans to the most at-risk populations, which would be enormously helpful in reopening economies, which we would obviously like to do sooner than later.

Second, and equally important, we know that the coronavirus expresses itself differently among different populations. For example, older men, racial and ethnic minorities, and those with particular underlying conditions seem to be more vulnerable to disease. It behooves us, therefore, to understand the molecular and environmental reasons for this differentiated response, and to develop and deploy therapies and vaccines that are targeted to those who are in need.

Today, we are looking for one-size-fits-all solutions because there's an urgency to find one. But eventually, scientists in my opinion are going to recognize that, because not everyone responds the same, different medicines are going to have to be developed to treat COVID-19 and other viruses.

We've already seen this in AIDS, and so I don't think the coronavirus is going to be different. We have to be really smart about how we address this pandemic. By the way, on September 3rd, PMC is organizing a virtual seminar, titledCOVID-19 and Personalized Medicine: Current Status and Lessons Learned. It is free, and if you want to register, you can do so on ourwebsite.

Ed, thank you so much for being with us today, and as we wrap up, I'd like to invite you to make any closing remarks or comments on the topics we covered today.

I'd really like to thank you both for your loyal support to the Personalized Medicine Coalition, and for giving me the opportunity to discuss these very important issues with your audience. I hope people will pay attention to personalized medicine. We believe it represents the future, and we also believe that if we invest in it, if we come together collaboratively as a community, we can have a health care system that we deserve based upon the developments in science and technology, which have never been more promising. Again, thank you for your attention, and I look forward to working with you and everybody on this podcast to move this field forward. It's not going to happen by itself.

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COVID-19 & Healthcare: Personalized Medicine is the Future - The National Law Review

With the recent death of actor Chadwick Boseman, many may be wondering how a seemingly healthy adult is diagnosed with a disease often thought of as illness of older adults. Although colorectal cancer is most often diagnosed in people 50 years or older and incidence rates in this age group are, in fact, declining, the number of adults under 50 diagnosed with colorectal cancer is rising. According to the National Cancer Institute, approximately 5 percent of all new cases of colorectal cancer in the United States are among persons 15 to 39 years old.

African Americansbear a disproportionate burden of cancer. Studies have shown that those who are diagnosed with colorectal cancer at a young age have worse survival outcomes compared to young white patients.

With improvements in prevention, early detection and treatment, there are more than 1.5 million colorectal cancer survivors living in the U.S. Still, an estimated 53,200 people will die this year, making this disease the third most deadly cancer among men and women in the U.S. Approximately 147,950 people will be diagnosed in 2020. Thats one in 23 men and one in 25 women who will develop colon or rectal cancer, the two malignancies that make up colorectal cancer.

At UC San Diego Health, a comprehensive team of medical, surgical and radiation oncologists use the most advanced treatment options, such as laparoscopic surgery and personalized medicine. At Moores Cancer Center, patients can enroll in clinical trials specifically for colorectal cancer.

Oncologists with Moores Cancer Center are available to answer questions about this disease.

###

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Is 43 Too Young for Colon Cancer? UC San Diego Health Experts Available to Talk About Colorectal Cancer - Newswise

Nanotheranostics, integrating diagnostic and therapeutic functions by nanoplatform, exhibits a great potential in precision and personalized medicine, and also raises the requirement on multifunctional nanomaterials in pursuit of both good biocompatibility and high theranostic performances. The emergence of diverse multifunctional nanomaterials and advanced nanotechnologies unprecedentedly simulates the evolution of nanotheranostics, and enables the integration of multimodal imaging and therapeutic functions in a single theranostic nanoparticle for high-efficacy theranostics of diseases. In engineering of theranostic nanoplatforms, biocompatibility and multifunction are two most important factors which need to be considered. Among various nanotheranostics, multimodal imaging-guided photothermal therapy has attracted intensive attention owing to its less invasiveness and lower side effects compared with conventional radiotherapy and chemotherapy.

In a new article published in the Beijing-based National Science Review, scientists in Shenzhen University, China, hypothesize that controllable incorporation of biocompatible Se element into the lattice of Te nanostructures for construction of TeSex nano-alloys could intrinsically tune the inherent cytotoxicity of Te nanomaterials, enhance the biocompatibility of Te nanomaterials and extend their functions for biomedical applications. In this work, a series of TeSex nano-alloys with different Se incorporating proportions are synthesized to investigate their biocompatibility and develop their theranostic functions. It is determined that the toxicity of Te nanomaterials mainly comes from irreversible oxidation stress and intracellular imbalance of organization and energy, which is exterminated by the nano-alloying by incorporating a moderate proportion of Se (x=0.43). The synthesized TeSex nano-alloy exhibits extraordinarily high NIR-II-photothermal conversion efficiency (77.2%), 64Cu coordination and CT contrast capabilities, enabling high-efficacy photothermal therapy of cancer under the guidance of multimodal PT/PA/PET/CT imaging.

Several main advances are achieved. (1) Advanced TeSex nano-alloys are facilely constructed to intrinsically eliminate the inherent toxicity of Te nanomaterials by the moderate incorporation of biocompatible Se. (2) Advanced mechanisms for Te nanomaterial toxification and TeSex alloying detoxification are uncovered. (3) Advanced theranostic performances with ordinarily high NIR-II-photothermal efficiency and multimodal PT/PA/CT/PET imaging capability are achieved by proposed nano-alloying strategy.

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Biocompatible TeSex nano-alloys for PT/PA/CT/PET imaging-guided NIR-II-photothermal therapy - Science Codex

SARASOTA, Fla., Sept. 1, 2020 /PRNewswire/ --Transcendent Publishing today announced the release of Male 2.0: Cracking the Code to Limitless Health and Vitality by author Tracy Gapin, MD, FACS. Since its August release, the book has already reached Amazon bestseller status. Dr. Gapin, a men's health and performance expert and member of the American Urological Association, provides a meaningful impact for men's health with this leading-edge approach.

Over the past thirty years, there has been a relentless population-based decline in mens' testosterone levels by over thirty percent. We've also seen a dramatic increase in the incidence of obesity. Over seventy percent of men are either overweight or obese, which is directly tied to energy, productivity, and overall health and performance. This has led to a men's health epidemic for the 159 million men in the United States.

The Male Method described throughout Male 2.0 was developed to help men lose weight, regain energy, optimize their hormones, and regain peak performance. "We need to go beyond testosterone. We need to take an individualized, systems-based approach to optimize men's health, performance and longevity," says Tracy Gapin, MD, FACS. "Driven by the power of epigenetics, genetics, peptides, and wearable technologies, we have gained incredible insight into some of the most misunderstood aspects of men's health and longevity."

JJ Virgin, New York Times Bestselling author of The Virgin Diet & Sugar Impact Diet said, "As a thought leader in men's health, Dr. Gapin has provided the modern-day blueprint to help men optimize their health and regain their vitality. Every man should read this book."

Clete Walker, CEO of Vituro Health, a prostate health company, said, "Male 2.0 is a revolution for men's health. After my father was diagnosed with prostate cancer, I made it my mission to seek out potential new modalities, and this data-driven approach is the future."

Male 2.0: Cracking the Code to Limitless Health and Vitalityis available on Amazon and during the month of September the print version is available for free at The Gapin Institute. http://www.GapinInstitute.com

About Tracy Gapin, MD FACS:Dr. Gapin is board-certified Urologist, world renowned Men's Health & Performance Expert, Author, and Professional Speaker. Using state-of-the-art biometric monitoring, nutrition and lifestyle intervention, Dr. Gapin coaches Fortune 500 executives and evolutionary leaders of business, sports medicine, and high performance. He specializes in cutting-edge precision medicine with an emphasis on epigenetics, providing men with a personalized path to optimizing health & performance. http://www.GapinInstitute.comEmail: [emailprotected]

About Transcendent Publishing:Since 2012, Transcendent Publishing has specialized in offering a variety of publishing and design services for today's indie author. http://www.transcendentpublishing.com

CONTACT:Leann Spofford[emailprotected]Tel: (941) 524-4592

SOURCE Gapin Institute

Home – MMG

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Men's Health Expert Tracy Gapin, MD Unveils Male 2.0 with a Revolutionary Protocol to Conquer the Men's Health Epidemic - PRNewswire

A postdoctoral position is available at the Faculty of Medicine, University of Helsinki, Finland to work in the research group of Dr. Jing Tang (https://www.helsinki.fi/en/researchgroups/network-pharmacology-for-preci...). The position is part of an Academy of Finlands research project that aims to do network pharmacology modeling to provide the mechanism of action of drugs and drug combinations for a systems-level understanding of cancer. The Tang group combines computational methods to offer improved efficiency methods to identify more effective cancer treatments for personalized medicine. The Tang laboratory is based at Research Program in Systems Oncology (ONCOSYS) (https://www.helsinki.fi/en/researchgroups/research-program-in-systems-on...) at the Meilahti biomedical campus.

Role description:

We are seeking at least one postdoctoral researcher to work on the computational methods to develop network pharmacology models for predicting drug combinations. The project is focused on strategies for predicting potential drug combination and patient subclasses by constructing multipartite networks using drug response data. The primary goal of the project is to analyse drug sensitivity datasets to exploit drug-target interaction data to explore the biological mechanism of drugs. A key aim of the work is to propose drug combination regimens focusing on patient-derived drug response data along with the providing a biochemical and biophysical understanding of a drug combination. Hematological malignances and ovarian cancer are the available datasets for this project. The post holder will be responsible for planning and conducting computational research within the project under the supervision of Dr. Mohieddin Jafari, and Prof. Jing Tang.

The ability to work well within a collaborative team is critical for this position. You will work with unique datasets derived from large-scale experiments associated with a diverse range of projects in pharmacology and molecular biology. Salary will be commensurate with qualifications and experience based on the University guidelines. The full-time position start Jan 2021. A six-month trial period will be applied.

Key requirements:

We are seeking a creative and highly motivated individual with primary interest in network science and biomedical data mining. Candidates should have a PhD in bioinformatics, computational biology, statistics, computer science or other related disciplines. The ideal candidate will have experience in at least one of the aforementioned areas, and a strong interest in the others. Previous experience with biological networks, omics datasets, and expertise in related statistics and modelling are considered an advantage. Solid skills in scripting/programming (preferably R and Python) are essential prerequisites for this position. Excellent communication and presentation skills in English, good organisational skills, troubleshooting expertise and the ability to work effectively to tight deadlines are desirable.

Appointment details:

The position is available from October 2020 onwards, and can be started later upon agreement. It is a two-year fixed-term position, with a possibility of extension. Trial period of 6 months will be applied. The salary will be based on level 5 of the demands level chart for teaching and research personnel in the salary system of Finnish universities. In addition, the appointee will be paid a salary component based on personal performance with the overall starting salary amounting to approximately 3300-3600 EUR per month, depending on the qualifications and previous relevant research experience of the candidate.

Application details:

Please submit your application via the University of Helsinki Recruitment System by clicking the Apply for the position button below. Internal applicants (i.e. current employees of the University of Helsinki) should submit their applications through the SAP HR portal. If you need support with the recruitment system, please contact recruitment@helsinki.fi.

Please attach the following documents to your application as a single PDF file:

The deadline for applications is September 30th 2020. Interviews will be conducted either in person or online. For more information on the position, please contact Dr. Mohieddin Jafari (mohieddin.jafari(at)helsinki.fi) and Prof. Jing Tang (jing.tang(at)helsinki.fi).

The University of Helsinki (UH), founded in 1640, is a vibrant scientific community of 40,000 students and researchers. It is one of the leading multidisciplinary research universities and ranks among the top 100 international universities in the world. It is currently investing heavily in life sciences research. UH offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development.

Together with the Helsinki University Hospital (HUS) and the Helsinki Institute of Life Sciences (HiLIFE), the Faculty of Medicine, University of Helsinki, constitutes the Academic Medical Center Helsinki (AMCH). This medical center has been very successful in international comparisons, ranking among the top 10 medical campuses in Europe and among the top 50 globally.

Research Program in Systems Oncology (ONCOSYS) consists of basic, translational and clinical researchers who use cutting-edge measurement technology, patient data and AI methods in cancer research and oncology. The overall objective of ONCOSYS is to understand the underlying causes of cancer progression or treatment resistance, and to develop effective diagnostic, prognostic and therapeutic approaches.

Due date

30.09.2020 23:59 EEST

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Postdoctoral Researcher in Biological Network Modelling job with UNIVERSITY OF HELSINKI | 223494 - Times Higher Education (THE)

West Palm Beach, FL, Sept. 01, 2020 (GLOBE NEWSWIRE) -- Medical Practice Income (MPI), a subsidiary of USA Equities Corp. (OTC Link: USAQ), a company focused on value-based healthcare solutions and physician-directed digital medicine, is proud to announce the early success of the QHSLab launch in South Florida. Since launching the platform on June 30, 2020, 159 medical practices have provided 374 allergy patients with a QHSLab-generated allergen immunotherapy prescription, generating an estimated $664,608 in reimbursement revenue to these physicians practices.

There are over 450,000 primary care physicians, including licensed nurse practitioners, in the United States. Many are reporting higher rates of fatigue and burnout due to long hours, heavy patient caseloads, and declining practice revenue from a lack of healthcare reimbursements. Primary care physicians are particularly overwhelmed by the number of patients suffering from allergies, which often signal other health related and immune compromising concerns. Doctors need smart, digital medicine solutions that save time and money, while delivering the right treatment to patients that need it. With the addition of QHSLab, not only will physicians be better equipped to treat patients, but they will also be able to sustain their practices with ongoing revenue through healthcare reimbursements, generating new income per practice, per year.

Allergies alone are estimated to affect 1 in every 5 Americans and costs upwards of $18 billion in direct health and medical expenditures annually. It not only impairs quality of life, but is responsible for as much as $4 billion annually in lost productivity due to work and school absences. When over-the-counter allergy medication treatment is no longer successful, allergen immunotherapy is recommended. Allergen immunotherapy is usually prepared by allergy specialists however, today there is a published shortage of board-certified allergy specialists available to treat the number of allergy sufferers.1 Patients must now rely on their primary care provider to effectively manage their allergies. Through our AI-enhanced, physician-directed platform, MPIs QHSLab, were increasing the primary care physicians ability to effectively address their patients chronic conditions, while saving them time and potentially expensive visits to a specialist when not absolutely necessary, said Troy Grogan, President and CEO of Medical Practice Income, Inc and USA Equities Corp.

The Fall of 2020 is soon upon us, but this season will be even more alarming than usual due to the ongoing spread and impact of COVID-19. Fredric Pullen MD, FACS, an Allergy and Ear, Nose & Throat Specialist based in Palm Beach Gardens, FL shared the following insight regarding QHSLab: Its so much easier for busy primary care physicians to have a software system that can automatically generate the patients allergy formulas for their appropriate immunotherapy, based on their allergy test results. It saves time and potential error which is a definite plus for non-allergy specialist doctors, especially in the age of COVID-19.

For more information about Medical Practice Income, or to become a participating physician, please visit https://www.medicalpracticeincome.com/opportunities.

About USA Equities Corp (OTC Link: USAQ)

On December 20, 2019 USA Equities Corp entered into and consummated a share exchange with the former stockholders of Medical Practice Income, Inc. (MPI), a Florida corporation. As a result of the Share Exchange, MPI became our wholly-owned-subsidiary. We are focused on value-based healthcare solutions, clinical informatics and algorithmic personalized medicine including digital therapeutics, behavior based remote patient monitoring, chronic care and preventive medicine. The Companys intellectual properties, products and information service portfolio is directed towards prevention, early detection, management and reversal of cardio-metabolic and other chronic diseases. Our principle objectives are to develop proprietary software tools, devices, and approaches, providing more granular, timely, and specific clinical decision-making information for practicing physicians and other health care providers to address todays obese, diabetic and cardiovascular disease population and is located in West Palm Beach, Florida. For more information, visit http://www.MedicalPracticeIncome.com/discover.

Forward-Looking Statements

This press release contains forward-looking statements which are identified by words such as may, could, believes, estimates, targets, expects, or intends and other similar words that involve risks and uncertainties. These statements have not been based solely on historical facts but on USA Equities Corp current expectations about future events and results. You should consider that as such statements relate to future matters, they are subject to various inherent risks, uncertainties and assumptions that could cause actual results or events to differ materially from expectations described in the forward-looking statement. Various important factors could cause actual results or events to differ materially from the forward-looking statements that USA Equities Corp makes, including, but not limited to, the risk that software development and studies may be delayed and may not have satisfactory outcomes, the risk that costs required to continue our Software as a Service (SaaS) or to expand our operations will be higher than anticipated and other risks described in the Risk Factors section of our Annual Report on Form 10-K filed by USA Equities Corp with the SEC on February 21, 2020. Except where required by law, USA Equities Corp. has no intention to update or revise forward looking statements, or to publish prospective financial information in the future, regardless of whether new information, future events or any other factors affect the information contained in this presentation. None of USA Equities Corp Directors, Consultants, or any other person named with their consent in this presentation can assure you that any forward-looking statement or result expressed or implied by any forward-looking statement will be achieved.

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Medical Practice Income, Inc., a Subsidiary of USA Equities Corp. (USAQ), Announces the Early Success of QHSLab Launch in South Florida -...

SAN FRANCISCO, Aug. 31, 2020 /PRNewswire/ -- The global lab supplies marketsize is expected to reach USD 49.6 billion by 2027, expanding at a CAGR of7.1%,according to a new report by Grand View Research, Inc. Focus on R&D drives the demand for lab equipment market, thereby boosting the market growth.

In June 2019, the D.O.D's Defense Logistics Agency settled the bidding process for USD 312.0 million contracts, for lab equipment and supplies. There are instances of huge government spending in the category including White House's budget of 2020 that provides USD 134.0 billion for federal R&D, including significant investments in R&D facilities and equipment.

Key suggestions from the report:

Read 120 page research report with ToC on "Lab Supplies Market Size, Share & Trends Analysis Report By Product (Equipment (Autoclaves & Sterilizers, Lab Air Filtration System), Disposables (Tubes, Gloves)), By Region, And Segment Forecasts, 2020 - 2027" at: https://www.grandviewresearch.com/industry-analysis/laboratory-supply-market

Laboratories have emerged as multipurpose research facilities in which various types of testing mechanisms, research analogies, and novel developments are carried out. This has also led to an increase in the demand for lab equipment and supplies market. Furthermore, the trend of research-based studies has been gaining traction over the past decade. This has resulted in the development of new laboratories in academic institutes, thereby boosting the market growth.

Recently, clinical laboratories have also gone through major technological advancements. With intense R&D going in the field of the pathogenesis of diseases and personalized medicine, advanced diagnostics methods and tests are being implemented extensively. Technological improvements in instrumentation continue to bring real benefits that accrue from greater ease of use, increased capacity, speed of analysis, higher precision, operational efficiencies, enhanced reliability, improved safety, and numerous other intangibles.

Grand View Research has segmented the global lab supplies market based on product and region:

Find more research reports on Medical Devices Industry, by Grand View Research:

Gain access to Grand View Compass, our BI enabled intuitive market research database of 10,000+ reports

About Grand View Research

Grand View Research, U.S.-based market research and consulting company, provides syndicated as well as customized research reports and consulting services. Registered in California and headquartered in San Francisco, the company comprises over 425 analysts and consultants, adding more than 1200 market research reports to its vast database each year. These reports offer in-depth analysis on 46 industries across 25 major countries worldwide. With the help of an interactive market intelligence platform, Grand View Research helps Fortune 500 companies and renowned academic institutes understand the global and regional business environment and gauge the opportunities that lie ahead.

Contact:

Sherry JamesCorporate Sales Specialist, USAGrand View Research, Inc.Phone: +1-415-349-0058Toll Free: 1-888-202-9519Email: [emailprotected] Web:https://www.grandviewresearch.comFollow Us: LinkedIn| Twitter

SOURCE Grand View Research, Inc.

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Lab Supplies Market Size Worth $49.6 Billion By 2027 | CAGR: 7.1%: Grand View Research, Inc. - PRNewswire

Patients across the Valley will soon feel more connected to their healthcare providers thanks to a mobile app changing the way clinical documentation and data entry are performed. Bayless Integrated Healthcare, an Arizona leader in integrating mental and physical health, has announced a partnership with Seattle-based healthcare technology company, Saykara, to implement this new technology in its eight locations across the Phoenix area.

The amount of data entry providers must do is on the rise due to additional requirements from insurance companies and government agencies. During a typical appointment, providers must simultaneously converse with patients while filling out electronic health records on a computer, which creates the feeling that providers are disengaged and multi-tasking, rather than offering their full attention. The data entry workload can be so great that providers often bring it home to complete during evening hours, contributing to fatigue and burnout.

The technology from Saykara reverses this trend by utilizing artificial intelligence to automate the challenging and time-consuming aspects of clinical documentation. This frees providers from their computers and restores quality facetime with patients.

Whole person wellness defines everything that we do at Bayless, says President and CEO of Bayless Integrated Healthcare, Justin Bayless. We know that the patient/provider connection is a deeply important part of that equation, and we continuously invest in the tools and technologies to improve that relationship. The more our patients feel heard during their appointments, and the more focused our providers are on them rather than data entry, the better our delivery of personalized medicine and the better our patient outcomes.

At the start of an appointment and with the patients consent, the Bayless provider simply accesses the Saykara mobile app from their iPhone. As the provider and patient engage, the app interprets the conversation and translates it to the data required for the electronic health record, reducing administrative busywork down to mere minutes, rather than hours.

Nobody wants to feel like theyre taking a back seat to administrative busywork when visiting a healthcare provider. This is when were all at our most vulnerable, says President and COO of Saykara, Graham Hughes, MD. By automating clinical documentation, our technology helps ensure that the time shared between a patient and provider is undistracted and that a trusting bond is forged.

The introduction of this technology at Bayless comes at a time when healthcare providers are increasingly reporting burnout amid the COVID-19 pandemic and may help alleviate some of the pressures they face. The result is reduced fatigue in providers, increased facetime with patients and a more trusting and deeply connected relationship between providers and the people in their care.

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Bayless Integrated Healthcare deploys AI to improve patient care - AZ Big Media

Background:Rheumatoid arthritis (RA) is one of the leading chronic inflammatory rheumatism. First-line therapy with synthetic disease-modifying antirheumatic drugs (sDMARD) is insufficiently effective in 40% of cases and these patients are treated with biotherapies. The increased use of these drugs each year is becoming a public health issue with considerable economic burden. This cost is 20 times higher than that of sDMARD. However, among patients treated with biotherapies, clinical practice shows that about one third will not respond to the selected drug. In nonresponse cases, practitioners currently have no choice but to perform an empirical switching between different treatments, because no tool capable of predicting the response or nonresponse to these molecules is currently available.

Methods:The study is a prospective, phase III, controlled, multicenter, and randomized, single-blind (patient) clinical trial, including RA patients with a previous failure to anti-TNF therapies. The main objective is the analysis of the clinical and pharmacoeconomic impact after 6 months of treatment. Intervention arm: prescription of biotherapy (rituximab, adalimumab, abatacept) using SinnoTest software, a prediction software based on proteomic biomarkers. Control arm: prescription of biotherapy based on current practice, without the SinnoTest software (any biotherapy). In addition, a substudy will be carried out within this trial to generate a biobank and further analyze the proteomic profile of the patients and their modification throughout the study.

Discussion:This clinical trial study will be the first validation study of a biotherapy response prediction software, bringing personalized medicine into the management of RA. We expect that the findings from this study will bring several benefits for the patient and the Health Care System.

Trial registration:ClincalTrials.govNCT04147026. Registered on 31 October, 2019.

Keywords:Anti-TNF agents; Personalized medicine; Prediction models; Rheumatoid arthritis.

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Efficacy, safety and cost-effectiveness of a web-based platform delivering the results of a biomarker-based predictive model of biotherapy response...

~Program to Focus on Advances and Breakthroughs in MS Research, Diagnostics and Technology~

~Special Press Events Planned to Give Media Access to Key Leaders & Late Breaker Investigators~

MIDDLETON, Wis., Aug. 31, 2020 /PRNewswire/ -- The 8th Joint ACTRIMS-ECTRIMS Meeting, the largest international conference focused on Multiple Sclerosis (MS) research, will be held in a virtual format from September 11-13, 2020, with a special encore session featuring Late-Breaking News and a COVID-19 Session on September 26.

At this virtual conference MSVirtual2020 world class scientists, neurologists, clinicians and researchers from around the world will be presenting the latest research, clinical trial outcomes and technology and diagnostic advances in multiple sclerosis (MS).

Media registration, which is open to editors, reporters, producers, and active freelance writers and bloggers, will allow access to the full program including plenary sessions, invited speakers and platform presentations. Press Registration can be completed online here, or to expedite press registration, you can send a request directly to the Press Managers. They can be reached at: [emailprotected]and [emailprotected]. They are also available to arrange interviews with participating leaders, presenters and experts that you may wish to connect with.

The MSVirtual2020 program at a glance can be found here. Key topics will cover:

Keynote speakers will include:

MSVirtual2020 will be hosting a Newsroom on Newswise that will house various media materials including press releases, videos, infographics, bios & photos of leaders and speakers, and other assets. Newswise will also host a few Zoom press events for media only that will allow registered journalists to access and ask live questions to ACTRIMS-ECTRIMS leaders and late breaking investigators. The link to the MSVirtual2020 Newsroom is: here, or at the following link: https://www.newswise.com/home/actrims. The conference hashtag is: #MSVirtual2020.

MSVirtual2020 Press Events:

SOURCE Americas Committee for Treatment and Research in Multiple Sclerosis

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The 8th Joint ACTRIMS-ECTRIMS Meeting - MSVirtual2020 - To be Held September 11-13 With A Special Encore Session Featuring COVID-19 & MS and Late...

NEW YORK, Sept. 1, 2020 /PRNewswire/ -- Peloton (NASDAQ: PTON), the world's largest interactive fitness platform, today announced the formation of the Peloton Health and Wellness Advisory Council, which will work closely with the company as it continues to look at how it can positively impact the physical, mental and emotional wellbeing of its community of Members from around the world. Peloton will collaborate with the council, which includes five renowned doctors, researchers and other medical professionals from the fields of cardiovascular medicine, cardiopulmonary exercise, neurology and neuroscience, and draw on their knowledge and expertise to help inform product and content development, community-focused and social impact initiatives, research projects and more.

"We constantly hear from our Members that Peloton has not only profoundly impacted their physical, mental and emotional health, but has also helped them cope with issues ranging from neurodegenerative disease or cancer, to PTSD or post-partum depression," said William Lynch, president, Peloton. "With the addition of this esteemed Health and Wellness Advisory Council, which includes some of the best minds in medicine, we can leverage scientific research and medical expertise to help us better serve our community through our content, products and platform."

The Peloton Health and Wellness Advisory Council includes the following experts:

Cardiovascular MedicineSuzanne Steinbaum, MD:Dr. Suzanne Steinbaum is an attending cardiologist, specializing in prevention. She has recently opened a private practice in New York City, at the Juhi-Ash integrative health center encompassing heart health, wellness and prevention, as well as the effects of stress and inflammation on heart health. She is the founder and President of SRSHeart, a personalized lifestyle management program using anatomy, physiology, functional data, genetics and metabolism, along with technology to reach ultimate cardiovascular health. She has been the Director of Women's Cardiovascular Prevention, Health and Wellness at Mt. Sinai Heart in New York City, after being the Director of Women's Heart Health at Northwell Lenox Hill. Dr. Steinbaum is a Fellow of the American College of Cardiology and the American Heart Association. She is a National Spokesperson for the Go Red for Women campaign and chairperson of the Go Red for Women in New York City. She is on the New York City Board of the American Heart Association and on the Scientific Advisory Board of the Women's Heart Alliance.

NeurologyRichard S. Isaacson, MD:Richard S. Isaacson, M.D. is a Neurologist, clinician and researcher who specializes in Alzheimer's prevention and treatment. He previously served as Associate Professor of Clinical Neurology, Vice Chair of Education, and Education Director of the McKnight Brain Institute in the Department of Neurology at the University of Miami (UM) Miller School of Medicine. Prior to joining UM, he served as Associate Medical Director of the Wien Center for Alzheimer's disease and Memory Disorders at Mount Sinai. Dr. Isaacson specializes in Alzheimer's disease (AD) risk reduction and treatment, mild cognitive impairment due to AD and preclinical AD. His clinical research has shown that individualized clinical management of patients at risk for AD dementia is an important strategy for optimizing cognitive function and reducing risk of dementia. He has also published novel methods on using a precision medicine approach in real-world clinical practice. He has also led the development of Alzheimer's Universe (AlzU.org) a vast online education research portal on AD with results published in the Journal of the Prevention of Alzheimer's disease, Journal of Communication in Healthcare, Alzheimer's & Dementia: Translational Research & Clinical Interventions, and Neurology. With a robust clinical practice and broad background in computer science, m-Health, biotechnology and web-development, Dr. Isaacson is committed to using technology and lifestyle interventions (such as physical exercise and nutrition) to optimize patient care, AD risk assessment and early intervention.

Vernon Williams, MD:Vernon Williams, MD is the Founding Director of the Center for Sports Neurology and Pain Medicine at Cedars-Sinai Kerlan-Jobe Institute in Los Angeles, CA. Dr. Williams is a former Commissioner for the California State Athletic Commission and current Chair of Neurological Health for the Commission's Medical Advisory Committee, as well as a former two-term Chair of the American Academy of Neurology Sports Neurology Section. He serves as a neurological medical consultant to local professional sports organizations such as the Los Angeles Rams, Los Angeles Dodgers, Los Angeles Lakers, Los Angeles Kings and Los Angeles Sparks. He also assists local colleges and numerous high school and youth sports/club athletic teams in this capacity. Dr. Williams is a board-certified clinical neurologist with very specialized areas of subspecialty: Sports Neurology and Pain Medicine. He is actively engaged in researching and developing innovative and effective treatments and technologies that help people recognize symptoms of a neurological injury sooner so that the work of treating them can happen faster, and with less potential for permanent damage. He passionately advocates for optimization of Neurological Health across the lifespan for his patients and peak performance clients.

Cardiopulmonary ExerciseAimee M. Layton, PhD:Aimee Layton, PhD is an Assistant Professor of Applied Physiology in Pediatrics in the Division of Pediatric Cardiology and the Director of the Pediatric Cardiopulmonary Exercise Laboratory at Columbia University Medical Center / New York Presbyterian Hospital. Dr. Layton recently joined the pediatric cardiology team after being director of the adult pulmonary exercise laboratory for a decade. This cross discipline experience provides Dr. Layton with knowledge of both how the lungs and the heart respond to exercise and the role of disease and sports in both adults and kids. Dr. Layton's prior research investigated respiratory biomechanics, with publications in both diseased and healthy populations. Her new research focuses on bridging the gap between the lab and the home, in hopes of impacting kids' behavior and relationship with exercise. Dr. Layton is a respected expert in clinical exercise physiology and has lectured internationally on the topic. Beyond her research, Dr. Layton has been performing exercise testing and counseling for both patients with lung disease and patients with heart disease. She plays an important role as one of the lead exercise physiologists for Columbia University Medical Center in testing, exercise counseling and research.

NeuroscienceJay Alberts, PhD:As a Cleveland Clinic Scientist, Ph.D., Jay Alberts' research is aimed at understanding the structure-function relationships within the central nervous system and evaluating the impact of behavioral and surgical interventions to improve motor and non-motor function in Parkinson's disease, stroke, Alzheimer's and other neurological populations. Human studies are currently ongoing to address these basic and translational research questions. Dr. Alberts is developing and validating new methods of using exercise and augmented and virtual reality to engage patient populations remotely. He is currently leading two multi-site clinical trials investigating the role of exercise in slowing the progression of Parkinson's disease. Dr. Alberts has led multiple successful technology initiatives aimed at better understanding patient symptoms and communicating these symptoms to providers. He is currently building AR and VR applications as prescriptive digital therapeutic systems for neurological patients. To date, Dr. Alberts has written 100 peer reviewed articles, has had uninterrupted extramural funding since 1999 and holds 10 patents.

For more information about Peloton or the Peloton Health and Wellness Advisory Council, please visit http://www.blog.onepeloton.com.

About PelotonPeloton is the largest interactive fitness platform in the world with a loyal community of more than 2.6 million Members. The company pioneered connected, technology-enabled fitness, and the streaming of immersive, instructor-led boutique classes for its Members anytime, anywhere. Peloton makes fitness entertaining, approachable, effective, and convenient, while fostering social connections that encourage its Members to be the best versions of themselves. An innovator at the nexus of fitness, technology, and media, Peloton has reinvented the fitness industry by developing a first-of-its-kind subscription platform that seamlessly combines the best equipment, proprietary networked software, and world-class streaming digital fitness and wellness content, creating a product that its Members love. The brand's immersive content is accessible through the Peloton Bike, Peloton Tread, and Peloton App, which allows access to a full slate of fitness classes across disciplines, on any iOS or Android device, Apple TV, Fire TV, Roku TVs, and Chromecast and Android TV. Founded in 2012 and headquartered in New York City, Peloton has a growing number of retail showrooms across the US, UK, Canada and Germany. For more information, visit http://www.onepeloton.com.

SOURCE Peloton

http://www.pelotoncycle.com

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Peloton Introduces Its First-Ever Health And Wellness Advisory Council - PRNewswire

EAGAN, Minn., Sept. 01, 2020 (GLOBE NEWSWIRE) -- Predictive Oncology (NASDAQ: POAI), a knowledge-driven company focused on applying artificial intelligence (AI”) to personalized medicine and drug discovery, today announced that management, will present at the LD Micro's "LD 500" Virtual Investor Conference, on Wednesday, September 02, 2020 3:40 PM Eastern Time.

A live webcast of the presentation will be available to the public at https://www.webcaster4.com/Webcast/Page/2019/36691. The webcast will be archived for 90 days following the live presentation.

About Predictive Oncology Inc.

Predictive Oncology (NASDAQ: POAI) operates through three segments (Domestic, International and other), which contain four subsidiaries; Helomics, TumorGenesis, Skyline Medical and Skyline Europe. Helomics applies artificial intelligence to its rich data gathered from patient tumors to both personalize cancer therapies for patients and drive the development of new targeted therapies in collaborations with pharmaceutical companies. Helomics’ CLIA-certified lab provides clinical testing that assists oncologists in individualizing patient treatment decisions, by providing an evidence-based roadmap for therapy. In addition to its proprietary precision oncology platform, Helomics offers boutique CRO services that leverage its TruTumor, patient-derived tumor models coupled to a wide range of multi-omics assays (genomics, proteomics and biochemical), and an AI-powered proprietary bioinformatics platform to provide a tailored solution to its clients’ specific needs. Predictive Oncology’s TumorGenesis subsidiary is developing a new rapid approach to growing tumors in the laboratory, which essentially fools” cancer cells into thinking they are still growing inside a patient. Its proprietary Oncology Discovery Technology Platform kits will assist researchers and clinicians to identify which cancer cells bind to specific biomarkers. Once the biomarkers are identified they can be used in TumorGenesis’ Oncology Capture Technology Platforms which isolate and help categorize an individual patient’s heterogeneous tumor samples to enable the development of patient specific treatment options. Helomics and TumorGenesis are focused on ovarian cancer. Predictive Oncology’s Skyline Medical division markets its patented and FDA cleared STREAMWAY System, which automates the collection, measurement and disposal of waste fluid, including blood, irrigation fluid and others, within a medical facility, through both domestic and international divisions. The company has achieved sales in five of the seven continents through both direct sales and distributor partners. For more information, please visit http://www.Predictive-Oncology.com.

Forward-Looking Statements

Certain matters discussed in this release contain forward-looking statements. These forward-looking statements reflect our current expectations and projections about future events and are subject to substantial risks, uncertainties and assumptions about our operations and the investments we make. All statements, other than statements of historical facts, included in this press release regarding our strategy, future operations, future financial position, future revenue and financial performance, projected costs, prospects, plans and objectives of management are forward-looking statements. The words anticipate,” believe,” estimate,” expect,” intend,” may,” plan,” would,” target” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Our actual future performance may materially differ from that contemplated by the forward-looking statements as a result of a variety of factors including, among other things, factors discussed under the heading Risk Factors” in our filings with the SEC. Except as expressly required by law, the Company disclaims any intent or obligation to update these forward-looking statements.

Investor Relations Contact:

Hayden IR James Carbonara (646)-755-7412 james@haydenir.com

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Predictive Oncology Inc to Present at LD Micro's "LD 500" Virtual Investor Conference on Wednesday, September 02, 2020 3:40 PM Eastern Time...

Precision Medicine Market Trends, In-Depth Research on Market Size, Emerging Growth Factors, Global 2020 Trends and Forecasts 2025

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Precision Medicine Market Analysis By Distribution Channel, Region And Forecast From 2020 To 2025|Johnson & Johnson, IBM, GE Healthcare, Illumina,...