StemCell Therapy

While genetics can play a significant role, the picture is much bigger.

If a man has type 1 diabetes, there is a 1 in 17 chance that his child may also get it. The oddsreduceto 1 in 25 if the woman has it, and the child is born before she is 25. Type 2 diabetes has astronger linkto genetics than type 1. Genes also playsome rolein conditions like hypertension and heart ailments. And just like these illnesses, mental health issues also have some degree of heritability. However, the stigma associated with mental health makes the heredity and its implications more difficult to navigate.

Recently, actor Rhea Chakraborty said in an interview that late actor Sushant Singh Rajputs mother had lived with depression. Sushant, who was found dead in his Mumbai apartment in June, reportedly by suicide, was living with mental health issues as well. In the aftermath of the incident, there have been discussions on how Sushants mental health struggles could have been hereditary. But what do we really know about the link between genes and psychiatric disorders?

There have been numerous studies in the past and ongoing to study these links. Astudyby Consortium on the Genetics of Schizophreniapinned the heredity of schizophrenia at 31% to 44% in nuclear and extended families respectively. When bipolar disorder was included in this, the heritability increased to 37% in nuclear families. And when it came to depression, in the same study, the heritability dropped to 34% in nuclear families and 20% in extended families.

Otherstudiessay that the chances of a person developing schizophrenia if a biological parent has the condition are 13 in 100, and for bipolar disorder, its around 30 in 100. Studies have also been done on identical twins, and have found that if one sibling has schizophrenia, theres a 40-50% chance the other will develop it, because they share the same genetic makeup. Alzheimers dementia is another disease known forhigh heritability.

Dr Sanjeev Jain, officer-in-charge of the Molecular Genetics laboratory and a professor of Psychiatry at the National Institute of Mental Health Sciences, (NIMHANS) in Bengaluru, points out that most things including looks are inherited from biological parents. Mental illness is not very different that way. The only thing is that we have not been able to figure out the precise mechanism by which the causal genes get triggered. Besides, people tend to forget that if there is a 10% chance you will develop a mental health condition due to heredity, there is also a 90% chance that you wont. Till date, we have not been able to predict mental illness, because it does not only depend on the genes, he says.

Dr Sanjeev has been involved in many research and molecular diagnostics projects on neuropsychiatric disorders including Obsessive Compulsive Disorder (OCD), alcoholism, dementia and schizophrenia for several years. He, along with his colleague, Dr Biju Viswanath, Associate Professor of Psychiatry at NIMHANS, are conducting a study Accelerator program for Discovery in Brain disorders using Stem cells(ADBS) using clinicalinvestigations, modern human genetics, and stem cell technology" at NIMHANS. The study has been on since 2016.

Dr Biju says that while there's a 60-70% risk of developing a psychiatric illness contributedby genes, there are several other factors that cannot be discounted. Dr Hema Tharoor, a psychiatrist associated with Chennai-based Schizophrenia Research Foundation (SCARF), points out that it is ultimately the gene-environment interaction that determines whether a person could develop a mental health issue.

There are studies, for instance, that look at siblings wherein one parent had schizophrenia but only one child developed it, and the other two did not. And its not just sociologicalfactors that playa major role in determining ones mental health, it is also things like the antenatal and postnatal care of the mother, low birth weight, infections during pregnancy, that determine the risk of developing these disorders in the persons life too, she explains.

One 2011study, for instance, found that the risk for schizophrenia increased with certain obstetric complications, famines, migrant status, and advanced paternal age. Severe pregnancy and perinatal complications also accounted for environmental risks.

Further, Dr Sanjeev points out, its very difficult to separate genetics and culture. At any point of time, you are expressing only a third of your genes. Different genes will express themselves at different points of time. Only when that expression crosses a threshold does it become a disease.

Besides, we simply dont know all the genes that contribute to the risk of developing a psychiatric disorder or illness. In the case of Alzheimers, studies haveimplicated215 potential causative genes. However, the study by the Psychiatric Genomics Consortium said that these only explain a small proportion of genetic variance, meaning that yet undiscovered genes remain. This is the case with other mental health issues and psychiatric disorders as well.

Even so, experts say it is not necessary that everyone who carries the risk increasing genes will develop the illness its just that the genes could increase the susceptibility of an individual to getting it, and the trigger threshold for the onset could be lower. So, for instance, if someone is at a higher risk to develop OCD due to heredity, and they have also been through trauma in childhood, it could cause early onset. But its also possible that they do not develop it at all, depending on the other factors, Dr Biju says.

Several illnesses like breast cancer and leukaemia have been proven to have a high heredity factor. In some cases, gene therapies have been devised to correct or replace certain genes that could cause some illnesses. However, this is not the case with mental illnesses. The study of the brain and mind is harder because you cant just do a biopsy of the brain, says Dr Sanjeev. However, the advantage to figuring out the genomic links to mental health is that once we know the cause, we can have better drugs to treat them. Most of the ones we use now are decades old.

Dr Biju similarly says, As a doctor, you want to see your patients health improve. Say, 50% of the patients get better with psychiatric medication, but the remaining struggle. But we do not know why the medication is not working. So, if we can understand how the illness or disorder originates by identifying the genes, you can identify the mechanisms; and then we can move to more effectivetreatments.

Dr Abhishek ML, a psychiatrist and a research faculty at Bengaluru-based Indian Institute of Science (IISc), says that another hope in studying the heredity of mental health issues is early preventability. Dr Hema adds, If we can establish the endophenotypes (the neurobehavioral traits that quantify genetic susceptibility to developing a psychiatric disorder), then it becomes a preventable risk. Special care can be taken then in, say, antenatal or postnatal care.

However, Dr Abhishek cautions that this sort of technology should be accompanied by destigmatising mental health, lest it leads to profiling of persons living with certain mental health conditions and impinging of their rights.

Read more:
Understanding mental health and its heredity: What experts know so far - The News Minute

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Four aging dams on the Klamath River are coming down. Their completion between 1921 and 1964 brought hydroelectric power to Northern California. It also blocked hundreds of kilometers of fish habitat, causing chinook salmon to effectively disappear from the upper river basin. But the removal of dams is no guarantee the fish will return, so a team of wildlife researchers hopes it can coax the fish to repopulate the river by exploiting a new discovery about salmon genetics.

The Klamath was once the third-largest salmon-producing river in the United States, and its fish are still prized by Indigenous tribes that live along its winding path. In the Klamath, as in many other rivers, chinook salmon come in two main types: spring-run and fall-run. Spring-run fish start their migration from the rivers estuary four to six months before their fall-run cousins, and their return spawning run takes them farther up the river. Over time, however, human activities including mining, agriculture, and dam construction all but swept spring-run fish from the upper Klamath. Today, only the fall run of chinook salmon is large enough to support fishing.

Though dam removal has yet to beginthat wont come for at least another yearJohn Carlos Garza and Anne Beulke are already investigating how to replenish spring-run chinook in the upper reaches of the Klamath River Basin. Garza is a geneticist with the US National Oceanic and Atmospheric Administrations Southwest Fisheries Science Center and a researcher at the University of California, Santa Cruz, where Beulke is pursuing doctoral studies. Their research was motivated by a mystery of salmon behavior.

People have long recognized spring- and fall-run patterns, but scientists couldnt actually explain what caused this distinction. We found these curious patterns again and again, Garza says, even though they were the same type of salmon. Once they acquired the technology to quickly sequence fish DNA, however, the scientists started analyzing the genes of salmon that spawned at different times. We found a single region in the genome thats responsible for the difference between early- and late-migrating fish, Garza says. This led them to wonder whether they could re-create the missing spring-run salmon by crossing fall-run salmon with those that have the early-migration gene.

Garza and Beulke are now preparing to apply their discovery. They plan to crossbreed and release hatchery-raised spring-run chinook from the nearby Trinity River with fall-run chinook from the Klamath. When the fish return to the hatchery once more to spawn, theyll crossbreed them again with more fish from the Klamath. With every generation, youll get fish with a higher percentage of their ancestry from the Klamath River, he says.

Ideally, Garza and Beulke should begin their project this September to take advantage of the 2020 spawning season. Their work was scheduled to start in March, but stakeholder agencies have been slow to agree. The current pandemic may influence their schedule, too. I cant even get into the lab right now, Beulke says.

Although other plans have proposed reintroducing spring-run fish from nearby rivers, Garzas method has the advantage of preserving the evolutionary history of the Klamath River fish. During his analyses, Garza noticed that some fall-run salmon included genetic descendants of the Klamaths earlier spring-run fish. Crossing spring- and fall-run fish from within the river, then, would enable new spring-run generations to also preserve the adaptive genetic patterns of their Klamath ancestors.

At this point, I like Carloss approach, says Kathleen OMalley, a geneticist at Oregon State University. Its a great opportunity to test the connections between a genomic region and run timing. There are a lot of variables, she adds, but its certainly a worthwhile project. It may take more years than anticipated, though, to actually get enough data points.

Garza is comfortable taking the long view. This is a process that occurs naturally, he says. Were just accelerating things. Within 10 years, we could have thriving spring-run chinook salmon populations.

After all, the dams have been up for 100 years.

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Coming Home to the Klamath - Hakai Magazine

CHICAGO--(BUSINESS WIRE)--Please replace the release with the following corrected version due to multiple revisions.

The updated release reads:

BASE10 AND DNA LINK COVID-19 ANTIBODY TEST YIELDS PROMISING RESULTS

DNA Links Serology Test Showed High Degree of Sensitivity and Specificity for Detecting COVID-19 IgG Antibodies

BASE10 Genetics, Inc. (BASE10) announced the results of an independent study that showed 95% sensitivity and 100% specificity for SARS-Co-V-2 IgG antibodies using AccuFind COVID19 IgG test by DNA Link, Inc. The study was performed at John Hopkins University.

BASE10 offers a COVID-19 Tracking and Recovery Program that assists employers in launching testing and monitoring strategies for COVID-19. The company has been working to incorporate antibody testing to track the full life cycle of SAR-Co-V-2.

Having a reliable COVID-19 antibody test solution is important to our clients in understanding how the virus has affected their specific population. Our team and DNA Link have worked hard these past months to reach this important milestone, says Dr. Michael Fang, BASE10 CEO.

The two companies now plan additional studies with a selected number of BASE10 clients to further meet regulatory compliance and improve clinical usability. We want to work very closely with regulatory bodies in everything we do, while making sure good tests are available to patients and their providers at the right place and time, says Elizabeth Freund, BASE10s VP of Innovation.

Solid science is a valuable commodity in these times of uncertainty, and we are committed to provide the scientific rigor of AccuFind COVID19 IgG to the world, says Dr. Jong-Eun Lee, CEO of DNA Link. We look forward to continuing to gain traction with BASE10 on this important mission.

_____________________

About BASE10 Genetics, Inc.

BASE10 is a precision medicine company based in Chicago. BASE10s proprietary platform identifies precision diagnostics technologies with high potential for improving health outcomes, and creates turnkey disease management solutions to be deployed at scale for insurance payors.

Media inquiries: media@base10genetics.com

About DNA Link, Inc.

Established in 2000, DNA Link is a genomics company based in Korea. The company produces high-quality genomic data through up-to-date technologies, discovers biomarkers for molecular diagnostics and precision medicine. DNA Link strives to lead personalized medicine and new drug target identification.

Media inquiries: ikjun.choi1@gmail.com +82-10-6291-6180

Continued here:
CORRECTING and REPLACING BASE10 and DNA Link COVID-19 Antibody Test Yields Promising Results - Business Wire

Sign up here for our daily coronavirus newsletter on what you need to know, and subscribe to our Covid-19 podcast for the latest news and analysis.

Novo Nordisk A/S, the Danish drugmaker, is exploring whether a new class of medicines that helps people lose weight and control diabetes also has potential in fighting Covid-19.

Research shows people afflicted by obesity and diabetes often fare worse in trying to overcome SARS-CoV-2. Now initial analysis of electronic medical records shows that GLP-1 drugs, which help patients keep blood sugar levels in check, could be a very meaningful therapy in helping people with diabetes battle Covid-19, Novo Chief Scientific Officer Mads Krogsgaard Thomsen said in an interview. He pointed to evidence the virus attacks cells that produce the hormone insulin.

The early indication is that the GLP-1 class is actually beneficial in Covid-19, he said. Thats not unexpected because this is the class of agents that target the risk factors for bad Covid-19 outcomes.

Novo shares recouped earlier losses to trade down 0.2% at 11:40 a.m. in Copenhagen.

GLP-1 drugs include Novos Ozempic for diabetes and Saxenda for obesity. Sales of such drugs, which also include Eli Lilly & Co.s Trulicity and AstraZeneca Plcs Bydureon, totaled more than $11 billion last year, according to a report from Grand View Research.

Novo, the worlds biggest maker of diabetes drugs, is studying the role such medicines could play as researchers and governments rush to find treatments to combat the coronavirus. The U.S. last month cleared use of convalescent plasma -- which uses blood from people who have recovered from Covid-19 to help those currently infected -- on an emergency basis for some cases.

That added to a growing list of therapies available to doctors. In May, regulators granted emergency authorization to the Gilead Sciences Inc. antiviral drug remdesivir, while dexamethasone, a widely available generic anti-inflammatory drug, has shown life-saving promise.

Patients with Covid-19 can suffer from an inflammatory condition in which the immune system overreacts to the virus, causing damage that is worse than the infection itself. Studies show that semaglutide, the key ingredient in Ozempic, dampens systemic inflammation in people with diabetes and obesity, Thomsen said.

Novo is carrying out further studies and will make the results public if it can substantiate the preliminary data, he said. Thomsen added that theres no clinical evidence that GLP-1 drugs have an antiviral effect on Covid-19.

More from

Novo has bet on GLP-1 drugs including Ozempic, forecast by analysts to generate $3.4 billion in sales in 2020. Saxenda is expected to cross $1 billion in sales this year. The company expects regulators to decide whether to approve semaglutide in obesity at the end of next year, or the middle of 2021 if it decides to use a priority review voucher, Thomsen said.

Research indicates that obese and overweight people are at high risk of suffering severe cases of Covid-19, with a French study last month finding that only one in 10 who end up in intensive care with the disease were in a range of healthy weight. Another report in August highlights concerns future vaccines for Covid-19 could be less effective for individuals with obesity due to a weakened immune response.

Obesity, hypertension and diabetes are big risk factors for bad outcomes, according to Thomsen. But it is also so that the virus puts further stress on your cardiometabolic condition.

(Updates with shares in fourth paragraph, obesity drug timeline in ninth paragraph, research in tenth paragraph)

Before it's here, it's on the Bloomberg Terminal.

View original post here:
Drugs That Fight Diabetes and Obesity May Treat Covid-19 - Bloomberg

Just because you have type 2 diabetes doesnt mean you cant ever let anything sweet pass your lips again. With a bit of strategizing, there are ways you can satisfy your cravings from time to time.

According to the American Diabetes Association (ADA), if you have diabetes, you can absolutely include sweets and desserts in your diet, as long as theyre part of a healthy eating plan and you dont overindulge. The ADA also recommends working with a registered dietitian, a certified diabetes care and education specialist (CDCES), or another diabetes healthcare professional to help you formulate an eating plan thats right for you.

When you eat or drink carbohydrates, such as sugar, starch, and fiber, your body breaks them down into glucose, raising levels in your blood, according to the ADA. If you have type 2 diabetes, your body isnt able to use insulin efficiently to move this glucose from your blood into cells, where its used for energy. So its important to take steps to make sure your glucose levels dont spike too high.

You also want to make sure you eat healthy foods that are nutritious and high in vitamins, minerals, and fiber, and avoid or eat only small amounts of foods that contain unhealthy ingredients such as added sugar, high amounts of sodium, and unhealthy fats.

Many sweets, including cakes, cookies, and candy, tend to be highly processed and chock-full of added sugar, refined flour, and saturated fats, which is why they should be enjoyed in reduced portion sizes as an occasional treat.

Try these tips from diabetes nutrition experts to include sweet treats in your healthy eating plan.

1. Allow yourself the occasional treat. Deprivation isnt likely to work, says Karen Lau, a registered dietitian and CDCES at Joslin Diabetes Center in Boston. Completely eliminating treats from your diet may backfire, and you may end up craving those foods more, notes Lau.

2. Plan ahead. Consider how many carbs youre getting in your meal, not just in your dessert, says Tami Ross RD, CDCES, author of What Do I Eat Now? A Guide to Eating Well with Diabetes or Prediabetes and a spokesperson for the Association of Diabetes Care and Education Specialists (ADCES). That total number should factor into your calculation of what you will eat on days you have dessert or a sweet snack.

Make sure the meal is balanced with other foods. Cut out carbs from the main dish, and save it for dessert instead, says Lau. For example, if youre planning to have dessert, skip the bread, pasta, or side of mashed potatoes at dinner.

3. Be mindful of sugar-free foods. Kristen Smith, RDN, a spokesperson for the Academy of Nutrition and Dietetics, suggests choosing foods that dont list sugar in the ingredients and have sugar substitutes instead. But keep in mind that these foods are often still made with flour and other carbohydrate-containing ingredients, says Smith.

4. Pay attention to what you drink. You probably know that regular soda, juice, and fruit punch are loaded with sugar, but sports drinks, energy drinks, and bottled tea can also raise blood glucose. Plus, these sugary drinks can contain as many as several hundred calories in just one serving, according to the ADA.

Healthier options to help you stay hydrated while still giving your taste buds a treat include seltzer water with slices of lemon or lime or water infused with fruit, says Veronica Brady, PhD, an advanced practice registered nurse at MD Anderson Cancer Center and assistant professor of nursing at The University of Texas Health Science Center in Houston. She is also a spokesperson for ADCES.

5. Swap out ingredients. In the kitchen, use whole-grain flours, such as wheat or oat, or versions made from nuts, such as almond flour, to help with blood sugar control, advises Smith. You can also look for recipes that use fruit or fruit puree to reduce or eliminate sugar, says Smith.

6. Designate a sweet treat day. Depending on how well your diabetes is managed and what you and your diabetes management team decide is best for you, you can decide how many days you can budget in per week or month to indulge your sweet tooth.

7. Focus on fruit. Not only is fruit delicious enough to satisfy your sweet tooth, but it has the added bonus of being healthier, because it has fewer carbs and no added sugar, compared with processed sweets, explains Smith. Plus, fruit has fiber, which is helpful, because it takes longer to digest and is less likely to cause a rapid rise in blood sugar, she adds.

That said, its still important to watch portion size and sugar content when eating fruit. If youre making a smoothie, for instance, youll want to stick to about 4 to 6 ounces rather than drinking a giant tumbler of it, notes Dr. Brady. And if youre snacking on dried fruit or using it in a recipe, make sure you take into account how much sugar it contains: Just 2 tablespoons of raisins or dried cherries can contain as many as 15 grams of carbohydrates.

Some great ways to enjoy fruit:

8. Pick something you really like. Rather than settling for something that you might not like as much just because its labeled low sugar, eat smaller portions of something you love, notes Lau. Not only will eating what you prefer leave you feeling more satisfied, but opting for the diabetes-friendly version may also prompt you to eat more than you should.

9. Take a few bites and make them last. Split that piece of cake with a friend, or just have half of a large cookie. The first few bites are often what you enjoy most, notes Ross. Try to stick to two or three bites, and practice mindfulness about what youre eating.

The next time you take a bite of a treat, try this: Eat more slowly, think about what youre eating, and savor the taste, suggests Brady.

10. Freeze bite-size treats. One great way to have portion-controlled sweets on hand is to freeze bite-size Halloween candies, says Brady. Eat one of these slowly for a treat, she says.

11. Keep temptation out of sight. Ask family members to be supportive and help you stay healthy by not eating sweets in front of you or bringing cookies or candy into the house. Store ice cream at the back of the freezer, and dont put sweets in front or at eye level in the pantry, where you can see them, suggests Smith.

12. Identify your cravings. Are there circumstances where youre more likely to be tempted? Think about what makes you crave sweets, says Smith. Are you often influenced by a TV show or commercial? Be mindful of activities that might spark a craving, advises Smith. If you know youre always tempted when you pass a certain restaurant or billboard, for instance, try to avoid going that way.

13. Dont be too hard on yourself. You dont need to always aim for 100 percent, notes Lau. Instead, she recommends striving to strictly follow your diabetes diet at least 80 percent of the time and allowing yourself the occasional indulgence.

Excerpt from:
How to Satisfy a Sweet Tooth if You Have Type 2 Diabetes - Everyday Health

The "United Kingdom Diabetes Market, By Continuous Glucose Monitoring (CGM), Blood Glucose (SMBG) Device, Insulin Pen, Insulin Pump, Reimbursement Company Analysis & Forecast" report has been added to ResearchAndMarkets.com's offering.

The report provides a complete analysis of the United Kingdom Insulin Devices Market.

United Kingdom Diabetes Market expected to reach USD 4.33 Billion by the year 2025

The market of Insulin Pen, Insulin Pump, Continuous Glucose Monitoring (CGM) Device and Self Monitoring Blood Glucose Device are growing due to the rising awareness for diabetes in the United Kingdom.

In the United Kingdom, there are more than a million people diagnosed with diabetes, and the number continues to grow. Diabetes is one of the biggest health challenges the United Kingdom is facing today. The growing health crisis and its complications will increase awareness of the risks, improve self-management among people with diabetes, bring about wholesale changes in lifestyle and improve access to integrated diabetes care services.

The National Service Framework (NSF) program is improving services by setting national standards to drive up service quality and tackle variations in care. In 2019, The Association of British HealthTech Industries (ABHI) had launched a diabetes section, enabling diabetes technology companies to work together in the first forum of its kind. The ABHI group is for any health technology company with an interest in diabetes care, from CGM and insulin pumps to apps.

Key Topics Covered

1. Introduction

2. Research & Methodology

3. Executive Summary

4. Market Dynamics

4.1 Growth Drivers

4.1.1 Rising Diabetes Mellitus in an Aging Population

4.1.2 Rising prevalence of diabetes in various age groups

4.1.3 Benefits of Insulin Pump over Multiple Daily Injection

4.1.4 Lifestyle-Compatible Treatment Options and Technological Advancement in Insulin Pump Devices

4.2 Challenges

4.2.1 Technological advancements in insulin infusion devices

4.2.2 Blood Glucose Meter Accuracy Problem

4.2.3 Low Compliance of Glucose Monitoring & Inadequate Reimbursement for SMBG Supplies

4.2.4 Safety Issues in Insulin Pump Devices

4.2.5 Difficulties Associated with the Pump

4.2.6 Adherence

5. United Kingdom Diabetes Market

6. United Kingdom Diabetes Population

6.1 United Kingdom Diabetes Population & Forecast

6.2 Type 1 & Type 2 Diabetes Population and Forecast

7. Market Share Analysis - United Kingdom Diabetic

7.1 By Types

8. Continuous Glucose Monitoring Market (CGM) - United Kingdom Market & Users

8.1 CGM Market by Components

8.1.1 Glucose Sensor Market & Forecast

8.1.2 CGM Transmitter Market & Forecast

8.2 United Kingdom - CGM User (2011-2025)

8.3 CGM Reimbursement in United Kingdom

9. Blood Glucose Device (SMBG) - United Kingdom Market & Users

9.1 Market

9.1.1 Type 1 & Type 2 (Diabetes)

9.2 Test Strips Market and Forecast

9.2.1 Type 1 & Type 2 (Diabetes)

9.3 Lancet Market and Forecast

9.3.1 Type 1 & Type 2 (Diabetes)

9.4 Meter Market and Forecast

9.4.1 Type 1 & Type 2 (Diabetes)

9.5 Blood Glucose Device (SMBG) Users and Forecast

9.5.1 Type 1 & Type 2 (Diabetes)

9.6 Reimbursement of Blood Glucose Devices in United Kingdom

10. Insulin Pen - Market & User

10.1 Insulin Pen User

10.1.1 Disposable Insulin Pen Users

10.1.2 Reusable Insulin Pen Users

10.1.3 Smart Insulin Pen Users

10.2 Insulin Pen Market

10.2.1 Disposable Insulin Pen Market

10.2.2 Reusable Insulin Pen Market

10.2.3 Smart Insulin Pen Market

10.3 Insulin Pen Needle Market

10.4 Reimbursement Policies

11. Insulin Pump - Market & Users

11.1 Insulin Pump Market & Forecast

11.1.1 Type 1 & Type 2 (Insulin Pump Market & Forecast)

11.2 Insulin Pump Users

11.2.1 Type 1 & Type 2 (Insulin Pump User & Forecast)

11.3 Differentiation Points of Insulin Pump Products in the United States

11.3.1 Animas Vibe

11.3.2 Medtronic 530G with Enlite

11.3.3 Insulet OmniPod

11.3.4 Tandem t: slim

11.3.5 Roche Accu-Chek Combo

11.4 Training Model for Patients & HCP - of Medtronic, Animas, Insulet Corp. & Tandem Diabetes Care

11.4.1 Medtronic

11.5 Insulet Corporation

11.5.1 Training Structure for New Patients - Insulet Corporation

11.6 Animas Corporation

11.6.1 Training Modules for New Patients

11.6.2 Training Modules for HCP (Health Care Professional)

Story continues

11.7 Tandem Diabetes Care

11.8 Reimbursement Policies on Insulin Pump

12. Insulin Pen - Company Analysis

12.1 B. Braun Melsungen AG

12.1.1 Overview

12.1.2 Initiatives & Recent Developments

12.1.3 Revenue

12.2 Eli Lilly

12.3 Artsana S.p.A.

12.4 BD

12.5 Novo Nordisk A/S

12.6 Owen Mumford Ltd.

12.7 Ypsomed AG

13. Insulin Pump - Company Analysis

13.1 Medtronic

13.1.1 Overview

13.1.2 Insulin Pump - Product Details

13.1.3 Insulin Pump - Latest Development & Trends

13.1.4 Revenue

13.2 Insulet Corporation

14. SMBG - Company Analysis

14.1 LifeScan Inc.

14.1.1 Overview

Read more:
United Kingdom Diabetes Market 2020-2025 Featuring Analysis of Companies Involved in Insulin Pens, Insulin Pumps, SMBG and CGM -...

For decades, two costly medical conditions have been rising on similar trajectories in America: obesity and type 2 diabetes (T2D). Over the last 40 years, adult obesity rates have more than doubled, with a similar rise in individuals with T2D. The link between these two conditions is further suggested by the fact that 70 percent of Americans are now living with obesity or overweight, and 90 percent of all T2D patients have obesity or overweight.

We also know there are strong medical connections between obesity and T2D. As an individuals BMI (body mass index) rises, their risk of developing prediabetes and type 2 diabetes also increases. This is especially true with increases in visceral, or abdominal, fat which is less responsive to insulin. The first line of treatment for T2D generally focuses on glycemic control, often with medications that promote weight gain.

Examining the connection between weight and T2D gives reason to look at more than glycemic control.

Going Beyond Simply Controlling Glucose Levels

Addressing obesity for patients with diabetes, however, enables the clinician to do more than simply control glucose levels: they can treat the underlying insulin resistance that drives T2D. Choosing medications that promote weight loss like GLP-1 agonists and SGLT-2 inhibitors over medications that promote weight gain like insulin and sulfonylureas can improve weight status providing added benefit to diabetes treatment. Unfortunately,two-thirds of people with obesity remain undiagnosed. Medical professionals cite lack of time as a major reason for why they dont discuss weight treatments with their patients, although patients who do receive obesity counselling from physicians trained in obesity medicine report receiving a higher quality of care.

More informed and effective obesity care translates to better diabetes prevention and care. Clinicians evaluating treatment for T2D should also consider obesity treatments ranging from lifestyle interventions to anti-obesity medications to bariatric surgery. For example, the risk of diabetes is reduced by 58 percent with a five to ten percent reduction of weight through lifestyle changes.

A Range of Cost-Effective Interventions

Bariatric surgery, typically associated with obesity treatment, can offer significant benefits for patients with T2D. Noted as a cost-effective intervention by the International Diabetes Foundation, bariatric surgery results in remission for most patients with T2D. Recently,a study published in the New England Journal of Medicine, compared an intensive lifestyle intervention to bariatric surgery and found similar improvements in weight loss and metabolic profile in patients with T2D.

All clinicians can guide patients towards better health outcomes when they understand the connection between obesity and diabetes. The Obesity Medicine Association(OMA) offers a wealth of resources that can help advance that understanding, including specialized continuing education tracks focused on managing adiposity-related diseases and the role of weight management in the treatment of diabetes.OMAs virtual fall conference, OvercomingObesity 2020, will highlight the latest research and best practices related to obesity. Additional OMA resources include The Obesity Algorithm, Obesity Treatment Proficiency Badges and American Board of Obesity Medicine (ABOM) preparation materials.

Health care professionals who embrace an approach to T2D treatment through medical, surgical and especially combined obesity interventions have the potential to make meaningful improvements for patients on multiple fronts.

For more obesity medicine resources or to become an OMA member, visit:www.obesitymedicine.org.

Nicholas Pennings, DO is board certified in Family Medicine and Obesity Medicine and is a fellow of the Obesity Medicine Association (OMA). He is an associate professor and chair of family medicine at Campbell University School of Osteopathic Medicine (CUSOM) and also serves as the director of the Campbell University Health Center. As a champion for advancing the education of current and future health professionals, particularly as it relates to obesity, Dr. Pennings is an executive director of clinical education for the Obesity Medicine Association. He has also infused obesity education into the medical school curriculum at CUSOM and has developed an online obesity education rotation through the OMA for clinicians in training.

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Improve diabetes prevention and care through obesity treatment - Medical Economics

Diabetes mellitus is an increasingly common disease in the United States and is one of the leading causes of death. It is more than just elevated glucose levels. Type 2 diabetes mellitus, as part of the metabolic syndrome, is often accompanied by obesity, hyperlipidemia and hypertension. It is a complex metabolic disease and is considered a heart disease equivalent.

Diabetes has such a huge impact on cardiovascular health that over a decade ago, the FDA started requiring cardiovascular outcomes data for any new antihyperglycemic drugs. While we have known for many years that improved glycemic control decreased cardiovascular risk, we did not have specific data that any particular drug decreased the incidence of cardiac morbidity or mortality. Now, several newer diabetes drugs have been shown to decrease the risk of either hospitalization due to cardiac events or cardiac death. This has changed the way pharmaceutical companies have been marketing their drugs and it has changed the way people look at diabetes.

People other than endocrinologists, that is. Endocrinologists have always treated diabetes as a cardiometabolic disease. As a matter of fact, the American Diabetes Associations (ADA) Standards of Medical Care in Diabetes includes a whole section on managing cardiac risk. For years, endocrinologists have been treating hyperlipidemia and hypertension as part and parcel of their diabetes management.

Ask an endocrinologist how many times they have started a patient on a statin after that patient had been told by other physicians that his cholesterol is normal. Or worse, how often another physician stops the patients statin because his level is good. Too many. Ive even had patients refuse statin therapy because their cardiologist told them they dont need it.

Patients with diabetes comprise a large portion of the population that endocrinologists see. There is now a push to create a new specialty, a new fellowship in cardiometabolic medicine. Most endocrinologists Ive communicated with are asking why? Why do we need this new separate fellowship? Isnt this what weve been doing all along?

If the argument is that there arent enough endocrinologists to go around (see my earlier post), then the answer isnt training more people in a different specialty, the answer is creating more endocrinologists. The answer is making endocrinology more attractive to medical students and residents.

Why go into endocrinology when our healthcare system rewards people for procedures and not cognitive work? It is my hope that the new CMS physician fee schedule and the new visit codes will correct some of this. In addition, we need more funding for endocrinology fellowship programs.

Only about 300 new endocrinologists complete training each year, meanwhile 1.5 million new cases of diabetes are diagnosed in the same time frame. Wouldnt it save the healthcare system millions of dollars to better compensate endocrinologists for managing diabetes and its comorbidities in order to decrease the need for cardiac testing and procedures and to prevent hospitalizations for cardiac events?

Diabetes is definitely a cardiometabolic disease. But we dont need a whole other specialty to start managing it. Endocrinologists have been at the front line of this all along.

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Cardiometabolic Health Fellowships: The Answer or Part of the Problem? - Endocrinology Network

Western eating habits have made their way to other countries, and an increase in diabetes is the unfortunate result.

September 5, 2020 by Diabetes Knowledge Leave a Comment

Worldwide rates of diabetes among the 65-plus population are on the rise, and have increased dramatically in the past 40 years. The US, China, and India have the highest rates of diabetes around the world. Diabetes puts seniors at a much higher risk for chronic wounds including life-threatening diabetic foot ulcers.

Diabetic foot ulcers can progress from an irritation on the bottom of the foot to a gangrenous limb. This would require amputation. Amputation, especially in developing countries is a result of diabetic foot ulcers. Wound experts can monitor the feet of diabetic patients for signs of a foot ulcer. Generally starting out as a red sore on the bottom of the foot. But seniors in developing countries dont always have easy access to wound care experts, making diabetes an even bigger threat to their overall quality of life.

A rise in diabetes is costly for any nations healthcare system. Threatening to reverse progress in countries like India and China. In both countries, many seniors rely on family members for care, and dont have access to expert wound care. Experts also estimate that both countries have high rates of undiagnosed cases, meaning that patients could be at risk for diabetic foot ulcers and not know it.

Patients in India are put further at risk for diabetic foot ulcers because of faulty footwear. However, one study found to be the cause of ulcers in one-fifth of patients.

The causes of diabetes in the U.S. are well known fast food and diets high in sugar provide an obvious explanation. But Western eating habits have made their way to other countries, and an increase in diabetes is the unfortunate result. Even in Japan, with a global reputation for a healthy diet, has also seen a dramatic spike in diabetes in the past few decades. This is due in part to the aging population the likelihood of developing diabetes increases with age. Along with the westernization of the Japanese diet.

In the Marshall Islands, a small group of islands near the Philippines, scientists have had a chance to study a dramatic dietary shift in a small population. Today, many locals subsist almost entirely on pre-packaged, imported food. As a result, over a quarter of the adult population suffers from diabetes.

It wasnt always this way. In the past, the Marshallese diet consisted mostly of seafood and local produce, and unsurprisingly, diabetes was practically non-existent. Researchers believe the introduction of white rice into the local diet may have started the trend toward more carbohydrate-rich, processed foods.

What can we learn from countries with especially low rates of diabetes? Italy has one of the lowest rates of diabetes in Europe, which tracks with recent studies. Research suggests that the Mediterranean diet is the best for lowering the risk of diabetes and obesity. A diet rich in healthy fats, in foods like fish and olives, as well as plenty of fresh produce. Seniors in long-term care may not have easy access to Mediterranean cuisine, but keeping those rough guidelines in mind can help seniors in long-term care make healthier choices and keep their diabetes symptoms in check.

Previously published on diabetesknow

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Bengaluru: An analysis of over 1,30,000 adults from 21 countries over nearly a decade has indicated a high risk of diabetes linked with the consumption of white rice. The risk is most prominent for the South Asian population, according to findings from a new, large-scale, long-term study.

The study was an international collaboration between researchers from various countries including India, China, and Brazil in Asia, North and South America, Africa and Europe.

Led by Bhavadharini Balaji of the Population Health Research Institute, Hamilton Health Sciences and McMaster University, Canada, the study was a part of the institutes Prospective Urban Rural Epidemiology (PURE) project.

The findings were published in the Diabetes Care journal in its September issue.

White rice is milled rice that has its germ (the part that sprouts), bran (hard outer layer), and husk (outer covering) removed. The polishing of rice further results in a bright and shiny appearance. While white rice has an appealing appearance and can be stored longer, the milling and polishing process remove nutrients such as vitamin B.

White rice has been linked to an outbreak of beriberi in Asia, caused by vitamin B-1 deficiency. It also causes the blood sugar levels to spike upon consumption due to its high glycemic index.

Globally, 42.5 crore people currently have diabetes, and this number is expected to increase to 62.9 crore by 2045, according to the International Diabetes Federation.

Studies have alluded to risk of diabetes associated with white rice for a few decades now, although findings have been contradictory. A 2012 study found that each extra serving of white rice increased the risk for diabetes by 11 per cent.

However, findings change depending on which country studies were conducted in. For example, a study of over 45,000 participants in Singapore found no substantial increase in diabetes was associated with white rice consumption.

Most such studies were limited to single countries. To beat this barrier, the authors of the new study extended it to 21 nations Argentina, Bangladesh, Brazil, Canada, Chile, China, Colombia, India, Iran, Malaysia, occupied Palestine territory, Pakistan, Philippines, Poland, South Africa, Saudi Arabia, Sweden, Tanzania, Turkey, United Arab Emirates, and Zimbabwe.

However, the South Asian population seems to show a pattern with white rice consumption and diabetes, despite a number of other lifestyle factors that increase the disease risk.

South Asians are genetically more predisposed to get diabetes, so there are both lifestyle as well as biological reasons for the high diabetes incidence, said Bengaluru-based physician Dr Gowri Kulkarni.

To understand the link between white rice and diabetes in South Asia, the researchers compared the data from India, Bangladesh, and Pakistan with the rest of the world.

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The study involved 132,373 individuals between the ages of 35 and 70, from these 21 countries, who were monitored for nine and a half years. Of these, 6,129 developed diabetes over the course of the study.

Participants were considered if they consumed more than one cup or 150g of cooked rice a day. Overall, the average white rice consumption was 128g a day among the study participants.

However, the team found that the highest consumption of white rice was seen in South Asia at 630g a day, followed by South East Asia at 239g and China at 200g per day. High consumption of rice resulted in lower consumption of other foods like wheat, fibre, red meat, and dairy products.

Carbohydrates make up nearly 80 per cent of calories consumed in many South Asian countries. Since the 1970s, carbs have become increasingly polished and refined as well, losing a lot of nutrition in the process.

Rapid urbanisation and economic development, especially in low- and middle-income countries, have led to a dramatic change in dietary intake and increased physical inactivity, which are related to the obesity epidemic.

Talking about the findings, Mumbai-based nutritionist Priya Kathpal said, I wouldnt say every white rice-eating family would have a diabetic person in their family A lot depends on the quantity of rice eaten, what its eaten with, and how frequently.

Also read:Brainwaves study can tell if a worker can handle crisis situation, IIT Madras research says

China and India are two of the worlds largest countries where rice is the staple food. Both also lead in the incidence of diabetes. However, the researchers found that there wasnt a significant association with white rice consumption and diabetes in China.

There could be many reasons for this, apart from other lifestyle factors. The scientists believe that the kind of rice the Chinese eat (sticky rice) could make a difference.

In India, studies have shown that during the last four to five decades of replacing hand-pounded rice with industrially milled white rice, the prevalence of diabetes in urban areas in India increased from 2 per cent in the 1970s to 25 per cent in 2015, and in rural areas from 1 per cent to 1416 per cent, respectively. White rice is considered to be one of the many main drivers of the trend, which followed improved socioeconomic growth and lifestyle modifications.

Studies have shown that substituting white rice with unpolished brown rice decreases the glycemic response by 23 per cent and the fasting insulin response by 57 per cent in overweight Asian Indians, but consumers do not tend to prefer brown rice due to its inconvenience of longer cooking duration, greater chewing difficulty, and lack of visual appeal.

Several patients that Ive asked to switch to brown rice have faced difficulty, as everyones grown up eating white rice, said Kathpal.

Taste is a huge factor, and brown rice often doesnt taste the same as white with vegetable curries and dals. Sometimes, white rice alternatives like even millets can be more expensive or not as easily available too, she said.

Doctors and dieticians are hesitant to recommend diets that are more expensive and less easily available even if they are healthier, as patients tend not to adopt them successfully.

A daily diet should always be easy to maintain and easily available. Only then can it be sustainable, said Kulkarni. Indians in general have poor protein intake in diet, and this has to do with available resources and choices. Most calories are from carbohydrates as they are cheap.

According to the researchers, in countries where rice is consumed the most or as a staple, the risk of increased diabetes among the public can be lowered by substituting white rice with alternate forms of healthier rice versions and adding more legumes or pulses to food.

Also read:One drink? Or two? Forget the guidelines, less is always better

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White rice linked to diabetes, especially in South Asia, says 21-nation study done over 10 yrs - ThePrint

Cypress resident Anne Imber takes a photo with her son Tristan Edgar, who was diagnosed with Type 1 diabetes in 2009 at the age of 12.

Cypress resident Anne Imber takes a photo with her son Tristan Edgar, who was diagnosed with Type 1 diabetes in 2009 at the age of 12.

Photo: Courtesy Of Anne Imber / Provided By Kimberly Pace, 9th Wonder

Cypress resident Anne Imber takes a photo with her son Tristan Edgar, who was diagnosed with Type 1 diabetes in 2009 at the age of 12.

Cypress resident Anne Imber takes a photo with her son Tristan Edgar, who was diagnosed with Type 1 diabetes in 2009 at the age of 12.

Cypress mother advocates with Beyond Type 1 DKA Campaign to differentiate diabetes symptoms from viruses like COVID-19

Excessive thirst, frequent urination, unexplained weight loss and exhaustion. If Cypress mother Anne Imber and her son had known what these symptoms might indicate, he could have been treated sooner for the serious health complications from his undiagnosed Type 1 diabetes.

Type 1 diabetes is a chronic autoimmune condition that causes the bodys immune system to mistakenly attack the insulin-making beta cells of the pancreas, explained Dr. Daniel DeSalvo, pediatric endocrinologist at Baylor College of Medicine and Texas Childrens Hospital.

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If a person with diabetes isnt receiving insulin, then they can develop a life-threatening condition called diabetic ketoacidosis, or DKA. It causes stomach pain, nausea, vomiting, tiredness, lethargy, sometimes it can cause rapid or heavy breathing, and if its severe it can lead to the point of confusion or even unconsciousness, DeSalvo said.

DeSalvo is on the science advisory board for Beyond Type 1, a nonprofit focused on building awareness and support for people with Type 1 and Type 2 diabetes worldwide.

Among the organizations initiatives is to prevent the development of DKA by educating people about the warning signs of Type 1 diabetes.

Imber became a Beyond Type 1 volunteer after her sons diabetes diagnosis and has been advocating on behalf of the DKA Campaign.

Texas was actually one of the first states to adopt the Beyond Type 1 DKA Campaign, Imber said. We have a really passionate group of diabetes advocates in the Houston area, and especially in the Cypress area, because we have a Type 1 diabetes school advocacy group.

One factor that can lead to the delayed diagnosis of Type 1 diabetes is the symptom similarities to some viral illnesses such as the flu or a stomach virus, DeSalvo said. During the COVID-19 pandemic, making people aware of Type 1 diabetes telltale symptoms is of vital importance.

On HoustonChronicle.com: Ventilation expert reveals how Texas schools can stop the spread of COVID in classrooms

Its an issue that Imber knows all too well.

Imber said her son Tristan was 12 years old when he and his sister contracted the swine flu in 2009 during the H1N1 pandemic.

My daughter immediately bounced back, Imber said. She was on the mend in two days. My son, he went down with the swine flu and then he never recovered his full energy that hed had before. He started suffering from extreme exhaustion. He started having a lot of weight loss.

There were many factors that Imber thought might be at play he was slimming due to a growth spurt; he had started running cross-country; and, of course, hed just been sick with the swine flu.

He would come home incredibly exhausted, falling asleep, and I really attributed it to the swine flu his recovery from the swine flu just not taking the path that his sister had taken, Imber said.

He continued to go downhill over the next month, losing 20 pounds in just four weeks. Hed tell his mom he was starving but was too nauseous to eat. He became more emotional than usual, Imber said. She knew something was wrong, so she made a Friday appointment with a pediatrician.

They knew immediately how bad it was, but they wanted us to come back Monday morning for a fasting blood glucose (test), she said.

Halloween happened to fall on that weekend. Thank god he did not eat his candy, Imber said. He was waiting for his braces to come off on Tuesday.

By Tuesday morning, his pediatrician had called to relay his diagnosis Type 1 Diabetes.

They realized Tristan had been going into phases of DKA because of his untreated condition.

Because he was running cross-country, his blood sugar would go really high and then it would drop again because of the activity, Imber said. So, it was a really unusual case and thats one of the reasons it took so long to manifest in really obvious terms of, something was seriously wrong.

Imber believes something as simple as an informational poster in the doctors office waiting room, like the ones distributed by the DKA campaign, could have tipped them off sooner.

He hadnt been sharing the excessive thirst and the frequent urination because 12-year-old boys dont do that with their moms; they dont talk about those things, she said. And I know had he been sitting in that office at that time with the DKA Campaign poster there, he would have been able to say, Mom, Ive been having these symptoms and that wouldve really prompted us to get immediate help Friday versus waiting until Tuesday to seek out support for him.

Nowadays, Imber said a DKA diagnosis warrants immediate hospitalization; but at the time, doctors felt the severity level of Tristans condition was low enough to treat him outside of a hospital. Imber said her son was fortunate to not have experienced the organ failure that some do from DKA. She knows of several cases in which lives have been lost because of an incorrect or delayed diagnosis. If her son had not been diagnosed in a timely manner, Imber doesnt doubt he wouldve ended up in the hospital.

We were lucky that he did not incur that seriousness of it, but we immediately saw relief from being able to be treated with the insulin under the care of an endocrinologist, and then started that learning process on how to manage it with the insulin dosing since his pancreas was no longer able to provide that hormone to regulate his food intake, Imber said.

Imber had attributed several of Tristans diabetes symptoms to the residual effects of his flu recovery a relatively common misidentification among people with undiagnosed diabetes, she said.

When its flu season, youll see a lot of people struggling and thinking, It is just the flu, but in reality there are some symptoms that really stand out that frequent urination, that excessive thirst that really differentiate from a flu symptom, Imber said.

The COVID-19 pandemic presents similar challenges for the diagnosis of Type 1 diabetes and DKA, explained Beyond Type 1 Leadership Council Member Michelle Berman.

We are seeing many families protecting themselves and wanting to avoid visits to doctors or the hospital, Berman said. And on top of that, if they arent armed with the knowledge of the warning signs, they also arent taking action when they appear. We really want families to get to the hospital or contact their physician right away, in spite of COVID or in addition to looking for the COVID warning signs. Type 1 diabetes does not stop just because theres a pandemic.

Berman serves as the National Family Advocate for the DKA Campaign.

Her child was diagnosed with Type 1 diabetes in 2007. She took him to the doctor after hed fainted from what she thought was abnormal blood pressure. After his diagnosis, Berman felt frustrated that shed never been made aware of the warning signs for Type 1 diabetes.

Berman learned of the Beyond Type 1 organization in 2016.

So, I partnered with Beyond Type 1 as a family advocate and began working on partnerships with the American Academy of Pediatrics and individual chapters in each state, Berman said. Together, Beyond Type 1 and the AAP partnered and brought awareness to families. Currently, I think theres 25 states across the country that partnered with Beyond Type 1 and disseminated materials warning signs, posters, fliers and handouts to families at well visits.

The campaign began its push to disseminate the information in November of 2016 and has distributed the material in 25 states to more than 28,000 pediatric offices serving over 90 million patients a year, according to Berman.

And thats just phase one.

With a grant from the Helmsley Charitable Trust Foundation, we were able to expand the campaign into phase two, into 10 states across the country, Berman said.

Phase two targets the general public, schools and businesses such as gyms.

In February of this year, the National Association of School Nurses partnered with Beyond Type 1 with the awareness campaign, and so thats been very exciting to expand beyond the pediatricians, Berman said. With the school nurses, were raising awareness of the warning signs, really to be distributed to tens of thousands of school nurses nationally in the United States. So, weve been really thrilled with the awareness and partnerships with this campaign.

For more information or to get involved, visit http://www.beyondtype1.org/dkacampaign or email dka@beyondtype1.org. Find Beyond Type 1 on social media: @beyondtype1.

mfeuk@hcnonline.com

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Cypress mother advocates with Beyond Type 1 DKA Campaign to differentiate diabetes symptoms from viruses like COVID-19 - Chron

LEONARDTOWN, MD (September 3, 2020) The St. Marys County Health Department is pleased to announce that the Overdose Response Program, Tobacco Cessation Program and Diabetes Prevention Program will be offered virtually for community members this Fall.

Overdose Response Program

The Overdose Response Program provides free training, open to anyone who would like to learn how opioids affect the body, how to recognize the signs of opioid overdose, and how to care for someone who may be experiencing an overdose until emergency help arrives. Participants can receive an overdose response kit via scheduled curb-side pickup that includes naloxone (Narcan) a life-saving medication that may be able to restore the breathing of someone who has overdosed on opioids.

Next Session: Wednesday, September 30, 2020, from 6:00 7:00 p.m.Learn moreor register at:www.smchd.org/overdose

Tobacco Cessation Program

The Tobacco Cessation Program is free and that takes place over the course of 8 weeks (weekly 1 hour sessions). Participants learn behavioral modifications, stress management, and other techniques to help them quit using tobacco products.

Next Series: Tuesdays, September 15, 2020November 10, 2020 from 5:306:30 p.m. Learn moreor register at:www.smchd.org/tobacco

Diabetes Prevention Program New!

The Diabetes Prevention Program helps participants establish and stick with positive lifestyle changes, such as healthy eating habits, physical activity and positive stress management, which can prevent or delay the onset of Type 2 diabetes. This free program includes 16 weekly sessions, followed by monthly sessions for ongoing support from a lifestyle coach.

Next Series: September 25, 2020 September 24, 2021 from 2:00 3:00 p.m.Learn more or register at:www.smchd.org/dpp

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Virtual Programs Announced for Overdose Response, Tobacco Cessation and Diabetes Prevention - The Southern Maryland Chronicle

Thousands of diabetes patients in the U.K. have been given hope that their illness could be put into remission by a soup-and-shake diet plan being offered by the National Health Service (NHS).

Those with Type 2 diabetes, which is more likely to affect people who are obese or overweight, are being encouraged to take up the low-calorie liquid diet after a trial involving 5,000 people showed that almost half of the participants saw their diabetes go into remission after a year.

Around 12.3 million people in the U.K are at risk of developing Type 2 diabetes, while in the U.S., one-third of Americans could be on their way to developing the disease, with 84 million Americans having pre-diabetes, a condition where people have higher than normal levels of blood sugar, according to the Center for Disease Control (CDC).

Around 10 percent of the U.S. population has diabetes, according to the CDC.

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Diabetes is also expected to cost the NHS 10 billion a year.

The year-long diet plan is being offered by the NHS to an initial 10 areas of England and only those who have been diagnosed with the condition in the last six years will be considered for the scheme.

Participants will be provided with diet replacement products such as shakes and soups for three months alongside support with exercise plans as well as managed plans to reintroduce ordinary, nutritious food.

Professor Jonathan Valabhji, NHS national clinical director for diabetes and obesity said: "This is the latest example of how the NHS, through our Long Term Plan, is rapidly adopting the latest evidence-based treatments to help people stay well, maintain a healthy weight and avoid major diseases.

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"There has never been a more important time to lose weight and put their Type 2 diabetes into remission, so it's good news for thousands of people across the country that practical, supportive measures like this are increasingly available on the NHS."

It comes as Public Health England data revealed that those with diabetes were more vulnerable to the COVID-19 virus, with a third of people who died in hospital with COVID-19 also having diabetes.

A new study published by the University of North Carolina showed that people with obesity are 113 percent more likely to be admitted to hospital with coronavirus and 74 percent more likely to need intensive care treatment.

Bev, who was one of the first patients to benefit from the diets during trials, said: "My goal for the first eight weeks of the low-calorie diet was to lose 5 percent of my body weight which I achieved in six weeks and in total I've lost over 10kgs, my Type 2 diabetes is now in remission and I no longer have to take any medication I am over the moon.

"Since the low-calorie diet program, my mindset has totally changed for the better and I look at food differently now my shopping habits are far healthier and, when I eat out, I'll go for a healthier option. The program has taught me moderation."

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Britain Begins Diabetes Trial After 50 Percent Recover Within One Year - Newsweek

For people who are struggling with diabetes, a late-breaking research has found out that it can be prevented or even be reversed by losing weight.

The research was presented on Monday at ESC Congress 2020.

In 2019, approximately 463 million people worldwide had diabetes, of which the vast majority (around 90 per cent) had Type 2 diabetes. It doubles the risk of coronary heart disease, stroke and death from cardiovascular complexities. Obesity is the main modifiable cause of Type 2 diabetes, while genetic make-up may also identify individuals with a greater likelihood of developing the condition.

"Because we are born with our genes, it might be possible to pinpoint early in life who has a high chance of developing diabetes during their lifetime," said principal investigator Professor Brian Ference of the University of Cambridge, UK, and the University of Milan, Italy.

"We conducted this study to find out if combining inherited risk with current body mass index (BMI) could identify people at the highest risk of developing diabetes. Prevention efforts could then concentrate on these individuals," Ference added.

The study included 445,765 participants of the UK Biobank. The average age was 57.2 years and 54 per cent were women. Inherited risk of diabetes was assessed using 6.9 million genes. Height and weight were measured at enrolment to calculate BMI in kg/m2. Participants were divided into five groups according to the GC of diabetes. They were also divided into five groups according to BMI.

Participants were followed-up until an average age of 65.2 years. During that period, 31,298 developed Type 2 diabetes.

Those in the highest BMI group (average 34.5 kg/m2) had an 11-fold increased risk of diabetes compared to participants in the lowest BMI group (average 21.7 kg/m2). The highest BMI group had a greater likelihood of developing diabetes than all other BMI groups, regardless of genetic risk.

"The findings indicate that BMI is a much more powerful risk factor for diabetes that genetic predisposition," said Professor Ference.

The investigators then used statistical methods to estimate whether the likelihood of diabetes in people with a high BMI would be even greater if they were overweight for a long period of time. They found that the duration of elevated BMI did not have an impact on the risk of diabetes.

Professor Ference said: "This suggests that when people cross a certain BMI threshold, their chances of diabetes go up and stay at that same high-risk level regardless of how long they are overweight."

He noted that the threshold is likely different for each person and would be the BMI at which they start to develop abnormal blood sugar levels.

"The findings indicate that most cases of diabetes could be avoided by keeping BMI below the cut-off which triggers abnormal blood sugar. This means that to prevent diabetes, both BMI and blood sugar should be assessed regularly. Efforts to lose weight are critical when a person starts to develop blood sugar problems," said Ference

"It may also be possible to reverse diabetes by losing weight in the early stages before permanent damage occurs," he added.

Continued here:
Diabetes can be prevented, or even be reversed - here's how - DNA India

Prediabetes could lead to type 2 diabetes in future - Know its symptoms and causes  |  Photo Credit: iStock Images

New Delhi: Type 2 diabetes has already reached epidemic levels around the world, with millions of people suffering from the condition. While the condition is very common, it is not completely curable, and can only be managed with the help of a healthy diet, regular physical activity and medicines. At the same time, diabetes can increase the risk of other health conditions like heart and kidney problems, if not managed well. In the wake of the COVID-19 pandemic that the world is struggling with right now, people with diabetes have been listed in the 'high-risk' category for risk of infection and complications due to coronavirus.

While many people know about type 2 diabetes, its causes and symptoms, very few are aware of prediabetes a condition that could be the onset of type 2 diabetes. Here is all you need to know about this condition its symptoms, and causes, and how you can keep yourself safe and healthy.

Prediabetes is a condition where your blood sugar or blood glucose levels are high, but not high enough to be termed as type 2 diabetes.

People who develop type 2 diabetes eventually, have prediabetes first. If prediabetes is not checked, it can transpire into type 2 diabetes within about 10 years, experts suggest. People who have prediabetes are at a high risk of developing type 2 diabetes in their life.

Prediabetes is very common, and it does not necessarily mean that one will suffer from type 2 diabetes. Unlike type 2 diabetes, prediabetes is reversible and can be managed with a healthy diet, regular physical activity, and some lifestyle changes.

While there is no particular cause of type 2 diabetes or prediabetes known, certain factors such as family history, genetics, and lifestyle are known to play a role. Obesity, especially around the abdomen, is considered an important factor for the pancreas to not produce insulin, or for the cells in the organs to not use it.

It is important to understand that prediabetes often does not show any signs or symptoms of the condition. Therefore, regular tests, especially for people who re aware that they are at high risk of developing the condition based on the causes listen above, are extremely vital.

Some uncommon symptoms of prediabetes include -

The bottom line is that a healthy diet comprising of high-fibre, nutrient and mineral-rich food, and a healthy lifestyle that comprises of mindfulness and regular exercise is important to stay healthy and keep the risk of diseases at bay, including prediabetes and type 2 diabetes.

Disclaimer: Tips and suggestions mentioned in the article are for general information purposes only and should not be construed as professional medical advice. Always consult your doctor or a professional healthcare provider if you have any specific questions about any medical matter.

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Prediabetes could lead to type 2 diabetes in future - Know its symptoms and causes - Times Now

Coffee can help reduce the risk of developing type 2 diabetes but just filtered coffee, rather than boiled coffee. New research study from Chalmers University of Innovation and Ume University, both in Sweden, show that the option of preparation method influences the health effects of coffee.

Numerous previous studies have actually shown a connection between high coffee intake and a minimized risk of establishing type 2 diabetes. Now, a research study from Chalmers University of Innovation and Ume University, offers new insight into this connection, using an unique approach to help distinguish between the effects of filtered coffee and boiled coffee.

We have identified specific molecules biomarkers in the blood of those taking part in the study, which indicate the intake of different sorts of coffee. These biomarkers are then used for analysis when calculating type 2 diabetes risk. Our results now clearly show that filtered coffee has a positive effect in terms of reducing the risk of developing type 2 diabetes. But boiled coffee does not have this effect, says Rikard Landberg, Professor in Food Science at Chalmers, and Affiliated Professor at the Department of Public Health and Clinical Medicine at Ume University.

With making use of these biomarkers, the researchers had the ability to show that people who drank 2 to 3 cups of filtered coffee a day had a 60% lower threat of establishing type 2 diabetes than people who drank less than one cup of filtered coffee a day. Consumption of boiled coffee had no effect on the diabetes risk in the research study.

Filtered coffee is the most common approach of preparation in many places, including the US and Scandinavia. Boiled coffee in this case refers to an alternative method of coffee preparation often used in Sweden and some other nations, in which coarse ground coffee is simply added straight to boiling water and left to brew for a couple of minutes. All the information used in the research originated from a group of Swedish subjects and was gathered in the early 1990s.

According to Rikard Landberg, many individuals incorrectly think that coffee has only unfavorable impacts on health. This could be since previous research studies have shown that boiled coffee increases the threat of heart and vascular diseases, due to the existence of diterpenes, a type of particle found in boiled coffee.

But it has been shown that when you filter coffee, the diterpenes are captured in the filter. As a result, you get the health benefits of the many other molecules present, such as different phenolic substances. In moderate amounts, caffeine also has positive health effects, he says.

The question is whether diterpenes likewise negatively affect sugar metabolic process and are therefore the cause of why boiled coffee does not help decrease the threat of diabetes, in the way that filter coffee does. The scientists still can not say the specific nature of the link.

Numerous other types of coffee preparation were not specifically examined in the research study, such as instant, espresso, cafetire, and percolator coffee. These kinds of coffee were not typical amongst the Swedish research study population when the data was collected.

However considered that espresso coffee, from traditional espresso machines or the now popular coffee-pods, is also brewed without filters, Rikard Landberg believes the health effects could therefore resemble boiled coffee, in regards to the threat of type 2 diabetes. Coffee made in a cafetire, or French press, is prepared in a comparable method to boiled coffee, so it may also not have the positive impact of reducing type 2 diabetes danger. It is uncertain whether instantaneous coffee, the most popular enter the UK, would be more similar to filtered or boiled coffee in this regard.

However the researchers are careful to note that no conclusions can be drawn yet regarding these other preparation techniques. Rickard Landberg likewise stresses that the health effects of coffee do not depend exclusively on if it is filtered or not. They likewise differ with how the coffee beans, and the drink in general, are handled.

To differentiate the diabetes risk for boiled and filtered coffee, a new strategy called metabolomics was used, in combination with timeless dietary surveys. Metabolomics makes it possible to identify the blood concentration of specific particles from a given food or drink and utilize that as an unbiased measurement of consumption instead of simply depending on self-reported consumptions from the questionnaires, which are prone to big mistakes.

Metabolomics is a fantastic tool, not just for capturing the intake of specific foods and drinks, but also for studying the effects that that intake has on peoples metabolism. We can derive important information on the mechanisms behind how certain foods influence disease risk, says Lin Shi, Postdoctoral researcher and the lead author of the study.

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Filtered Coffee can help slow the risk of developing type 2 diabetes - Drew Reports News

One sign to note is having sweet-smelling pee.

A person with uncontrolled diabetes may have blood glucose levels that are dangerously high, and as the body tries to get rid of the extra glucose in the urine it can cause a sweet smell, according to Medical News Today.

The site adds: People with sweet-smelling urine due to diabetes may notice other symptoms, including exhaustion, extreme thirst, appetite changes and unexplained weight loss.

Its important to note other conditions can cause a persons pee to smell.

READ MORE:How to live longer: Consume this spice to reduce heart disease risk and inhibit cancer

Smelly pee accompanied with lower back pain, pain when peeing and blood in pee can be caused by kidney stones, says the NHS.

And smelly pee accompanied by yellow skin and eyes (jaundice, tummy pain, nausea and vomiting can be a sign of liver failure.

But this isnt the only way a persons pee can be affected.

Polyuria is a condition where the body urinates more than usual and can be triggered by Type 2 diabetes.

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A person may also pass excessive or abnormally large amounts of urine each time they urinate.

Polyuria is defined as the frequent passage of large volumes of urine more than three litres a day compared to the normal daily urine output in adults of about one to two litres, explains Diabetes.co.uk.

It is one of the main symptoms of diabetes (both type 1 and type 2 diabetes) and can lead to severe dehydration, which if left untreated can affect kidney function.

The most common sign of polyuria is producing abnormally large volumes of urine at regular intervals throughout the day and night.

The charity adds: Having some of the signs and symptoms of diabetes doesnt mean you definitely have the condition, but you should always contact your GP, just to make sure.

A healthy diet and keeping active will help you manage your blood sugar level, says the NHS.

It advises you eat a wide range of foods, including fruit, vegetables and some starchy foods like pasta, to keep sugar, fat and salt to a minimum, and to eat breakfast, lunch and dinner every day - do not skip meals.

It also advises you do 2.5 hours of activity a week.

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Type 2 diabetes symptoms: The sign in your urine you could have the chronic condition - Express

Wearing face maskswith reading glasses is now worry-free-thanks to The University of Wisconsin and YouTube's Lennon Rodgers, who posted a do-it-yourself (DIY) hack in his channel that demonstrates the step-by-step procedure for people to create their own 'Badger Seals.' The university's innovation will help prevent hot steam from human breath exiting the mask and fogging-up lenses in the process.

Many people who wear reading and shaded glasses, together with the required face masks, who stroll around the streets and public areas, are bothered by the fog that it causes to the lenses. This fog is bothersome as it requires users to remove and clean the glasses to clear-up vision.

The American Academy of Opthalmology (AAO)recognizes this dilemma for people who wear prescription glasses because this is considered to be a potential danger when walking, driving, and other essential actions are visually impaired due to the lenses' fog.

The University of Wisconsin-Madison College of Engineering releases a reporton the "mask fitters" that prevent people from fogging up their glasses. The university referred to this as the "Badger Seal" and shared the step-by-step procedure on various Open Document sources in Google Slidesand PDFs.

David Rothamer and Scott Sanders spearheaded this design for the public to use and create on their own. The researchers and engineers even provided 3D images available for 3D printing for ease of creation.

ALSO READ: CDC: COVID-19 Vaccines Will Administer on 'Day of the Dead' as Experts Fear the Rush

The Badger Seal is a soft and flexible mask fitter frame that locks the mask in place, significantly improving the cover's seal in a person's face. The currently available face masks are fitted for the general public and do not cater to specific facial shapes.

This leaves some people to have some gaps for air to enter and escape, thus defeating the purpose of protection against viruses, prominently, the Novel coronavirus, or COVID-19.

The University of Wisconsin promises that this design will enhance a 3-layer face mask's protection more effectively. Badger Seals can also be manufactured cheaply and easily by people who have no experience creating various designs.

Here is a rundown of the components needed to create a DIY Badger Seal right at your home's comforts.

Tools:

Materials

The researchers, along with Lennon Rodgers, created instructional videos that demonstrate the Badger Seals' creation and function. There are three types of seals (A, B, and C) to choose from according to your preference and material availability.

The three types of Badger Seals offer the same design of frames but are intended for different face sizes and materials. Type A is designed for the average facial size with the tie-on design, Type B is intended for those with slightly bigger face size (those with beards), and Type C is intended for those who will utilize earloops for easier installation.

ALSO READ: Elon Musk Gets German Minister's Full Support in Trip to Berlin Gigafactory Despite Anti-Tesla Protests

This article is owned by Tech Times

Written by Isaiah Alonzo

2018 TECHTIMES.com All rights reserved. Do not reproduce without permission.

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WATCH: This Badger Seal Hack Promises a Fog-Free Experience While Wearing Face Masks; Vision Impaired No More - Tech Times

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Global Tissue Ablation Market 2020 by Company, Regions, Type and Application, Forecast to 2025Boston Scientific, Abbott, Johnson & Johnson,...