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If youre like me during the COVID-19 pandemic, your TV viewing habits have consisted of two guilty pleasures: reality TV and, of late, the return of live sports.

Terry Bradshaw is synonymous with live sporting events, as hes helped set up NFC matchups on FOXs NFL coverage since 1994. A Pro Football Hall of Famer, four-time Super Bowl-winning quarterback and broadcast icon, Bradshaw is adding reality TV star to his resume with his new show, The Bradshaw Bunch, premiering on hayu Canada on Friday, Sept. 18.

I caught up with Bradshaw ahead of the premier of his new show, which will release new episodes for stream or download every Friday, in anticipation of the Week 2 NFL schedule to find out what hes looking for, what players he loves to watch and how playing in his era compares to playing now.

Sportsnet: Did you ever think youd be doing a reality show?

Terry Bradshaw: Well, actually, this is my second reality show.

I did a show with NBC called Better Late Than Never, which is about a bunch of old actors and football players and boxers George Foreman, Henry Winkler, William Shatner and a young comedian named Jeff Dye. We travel around the country, and we did that show for two years and then thought we were going back out. NBC pulled the plug on it. And that was it. So, I have done one before this one.

This show was brought to me by Jason Ehrlich, who was executive producer of Better Late Than Never. He had come to a birthday party and he had seen my three girls and how they interacted with me and how much fun we had together. Light bulb went off.

I said, OK, lets do this. Away we went.

SN: Weve all consumed more TV during the pandemic. What are you watching? What reality shows do you watch?

TB: Duck Dynasty was pretty much it. Thats the only reality show I watch. Im not a reality guy. Im an old movies guy. I like to watch old movies. My wife, she likes to watch old movies. We love documentaries and we love sporting events. So glad they are back.

SN: On your NFL show on FOX, youve got a couple of co-hosts who have done some reality shows themselves. Have they weighed in?

TB: Howie thinks its going to be a hit. Jimmy thinks the same thing. He thinks its going to be funny. Michael Strahan was kind of surprised that I would do something like this, but he thinks it will be good.

All of them are very, very encouraging. Theyre very polite because theyre really good friends. Now, the show airs Friday, though. By Sunday, when I get there Sunday, they may go, T.B., what were you doing? They might be getting ready to rib me waiting for me in my parking spot on Sunday. But otherwise, everybodys asking, Whens the show? Whens it going to be on?

And its about my family. They know my family. They know my grandkids. So, you know, theyre very supportive right now.

SN: The reality show that you help bring to us as viewers is the NFL. Looking at the star character of the league, Patrick Mahomes and his big arm, you have something in common with him: when you played you were known for your arm talent. How do you evaluate the way guys like Mahomes can spin it now?

TB: I think Mahomes has got a good arm. He doesnt have a howitzer, but he can throw it. Hes very good in traffic. Great peripheral vision, throws it from all angles, very accurate, good under pressure, quick release. Tremendous talent.

Weve got other guys. The guy who played against him in Week 1, Deshaun Watson. He can really spin it and probably spin it a little better than Patrick. Hes not Patrick Mahomes, but is awfully good. Weve got Ben Roethlisberger who can really throw.

But the face of our league is, youre right, Patrick Mahomes from Kansas City. That is just a special talent and fun to watch any time. Hes one of the few players that I know, hes on television, Im watching that. Of course, my wife is a Kansas City Chiefs fan, so I have to be careful when Im on the air. Stay off of our boy, she says, because he sent her a signed helmet. And so, you know what that means. He bought my mouth.

SN: But I mean, the Pittsburgh Steelers helped you buy your house. So how does that work?

TB: Exactly.

Well, she knows for a fact that if it went between Pittsburgh and Kansas City, youre history. Thats where you draw the line. Lets not get crazy here. I mean, I spent 14 years at this organization. We won a lot of Super Bowls.

SN: If you had to build the perfect QB from the guys playing right now you could Frankenstein it up how would you build it?

TB: I would start with the strength of Roethlisberger.

I would follow that up with Tom Brady. I mean, theres so many guys that have the clutch gene. He is very much clutch. Hes great in the fourth quarter. Hes great in overtime. Its just amazing. I probably take Bradys calmness under pressure.

Ill take Drew Brees for accuracy. Escape ability, athleticism and the wow factor is Mahomes.

Three out of the four quarterbacks have strong arms. Probably fans would have no idea the strongest arm of all of them Brady believe it or not has a very strong arm.

Ive got a pretty good answer. You take those four players; I got a pretty good quarterback. Yeah, you win some games there.

SN: Youre in your 70s. Youve got so much energy, but you mentioned Tom. Hes 43 now and still playing. Can you imagine that?

TB: Yes, I can imagine playing nowadays at that age as much as I love playing. Had I not gotten hurt, my goal was to play and last to 40. I missed that target as I was 33.

But I missed it by seven years. So, I cant imagine. But I also understand it. Why not? Listen to what a young man does. A kid does. He dreams of playing in the NFL. Its his passion. And he gets there, and the dream comes true. And then its, I want to win championships and that comes true. And theres just nothing greater in life. Experiencing your dream unfold in front of you. And you have tremendous success at what you envision is the greatest job in the world, playing quarterback in the National Football League.

So, yeah, I certainly can get it. Why would you want to retire when youre doing what you want to do? You love what you want to do. You have a good team around you. So, youre competitive and youre making tons of money. Why give that up? So, I dont blame him whatsoever. I got hurt. And once it was over, you cant go back. Im proud of what hes doing and all of what hes doing. There is not many guys willing to do what he is doing this, you know, vegetable ice cream and stuff like that.

God bless him for that. Sounds like horrible, horrible ice cream. If Im eating ice cream, Im eating real, peach ice cream. Thats the real deal.

SN: Absolutely (laughs). Is todays game easier for quarterbacks now than when you played?

TB: Yeah, absolutely.

Professional football in Canada or in the National Football League, to play the position of quarterback, its not easy to handle the pressure, block everything from your mind, separate coverages, deliver the ball without realizing that people are hanging all over you.

Ive got one of the greatest pictures, most exciting pictures I have of myself: just all you see are people and at the very top of my hand with the football coming out of my hand and you can hardly see me.

That is the coolest picture I have ever seen. I just love that it shows me that Im oblivious to whats around me. And thats what you have to have to play quarterback.

It is easier to play in the sense that when I played in the 70s, you could get hit, you could get body slammed. You didnt have a suspension helmet, early part of my career, no chinstraps. I mean, the rules were changed back in the late 70s. It slowly started changing to where you couldnt jab or jam a receiver at the line of scrimmage up to five yards. Get your hands off of it as opposed to bump-and-run all over the football field.

So, its a totally different game. The game you see today in the NFL is the old AFL of the 60s. Thats why Ive often said 40, 50 times passing is the reason they did it because passing the football is exciting. And the NFL of the first 70 years from the first day, up to about 78, was just hard run, run, run, play action, run, run. Boring.

And the merger of the AFL and NFL was predominantly because the AFL was gaining. They were garnering ratings, taking them away from CBS, and it was because their brand of football was exciting. It was really fun to watch.

And what youre seeing today is the 60s of the AFL, especially in the last year. Its so much fun to watch.

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Q&A: Terry Bradshaw on the perfect QB, Bradys longevity and reality TV - Sportsnet.ca

In a study published in the US National Library of Medicine National Institutes of Health, the effect of ginger on the lipid levels was investigated.

The study noted, 45 patients in the treatment group and 40 patients in the placebo group participated in this study".

There was a significant reduction in triglyceride, cholesterol, low-density lipoprotein (LDL), very low-density lipoprotein, levels of before and after study separately in each group," it continued.

Mean changes in triglyceride and cholesterol levels of the ginger group were significantly higher than the placebo group.

Mean reduction in LDL level and increase in high density lipoprotein level of ginger group were higher than the placebo group, but in VLDL level of placebo was higher than ginger."

READ MORE:Best supplements for the heart - the 2p capsules to protect against heart disease

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How to live longer: A spice known to help curb cancer growth and boost longevity - Express

While there are few studies demonstrating the exact benefits of drinking celery juice, a lot of research points to how celery and its seeds can promote healthy living.

A study published in 2013 investigated whether the chemical 3-n-butylphthalide (3nB) in celery seed extract has antihypertensive properties.

Thirty participants with high blood pressure took part, and each consumed a capsule containing 75 milligrams of celery seed extract, twice a day for six weeks.

After this time, the participants experienced a significant decrease in blood pressure.

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High blood pressure can lead to serious problems such as heart attacks and strokes.

But according to the researchers, 3nB may lower blood pressure by reducing the buildup of fatty deposits within the arteries and increasing the elasticity of artery walls.

Celery may also benefit a persons cholesterol levels.

High cholesterol is when a person has too much of a fatty substance called cholesterol in their blood.

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Too much cholesterol can block the blood vessels and make a person more likely to have heart problems or a stroke.

But a 2014 study investigated the effects of celery leaf extract on the cholesterol levels of rats fed a high-fat diet.

The rats were fed celery leaf extract for 30 days, after which they showed a significant decrease in low-density lipoprotein (LDL) or bad cholesterol when compared to rats that didnt receive the extract.

Celery contains some beneficial antioxidants, one being luteolin.

The researchers found rats that were continuously treated with luteolin had reduced brain cell damage and improved learning and memory.

A different review published in 2015 looked at the effect of different plant chemicals on rodents with Alzheimers disease.

Researchers found apigenin, another antioxidant found in celery, limits damage to a variety of brain processes.

This could delay and slow the progression of Alzheimers disease.

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How to live longer: The juice that could ward off high blood pressure and boost longevity - Express

SAN FRANCISCO, Sept. 16, 2020 /PRNewswire/ -- A leading authority and author on aging partners with an award-winning tech journalist for the new monthly podcast, What's Next: Living Longer, Better, Smarter launching today. The hosts, Mary Furlong, a successful entrepreneur in the $8.3 trillion longevity economy, and former CBS, Bloomberg and public radio reporter, Fred Fishkin, will offer fresh perspectives into the worlds of technology and aging by interviewing notable thought leaders on a variety of topics focused on adults age 50+.

"We are delighted to be partnering with technology media expert Fred Fishkin to highlight trends in the longevity market," said Mary Furlong, the executive producer of the What's Next Longevity conferences which offer a platform for entrepreneurs to build sustainable brands. "Fred and I worked together 20 years ago through our CBS partnership and are pleased to be leveraging our knowledge base and distribution to bring a fresh set of perspectives around healthy aging using technology."

"Mary is a leading voice and advocate for seniors, longevityand I have to say it living longer, better and smarter!" said Fred Fishkin, who is re-teaming with Furlong after having worked with her at Third Age in the late 90s. "It is an opportunity to bring the depth of her knowledge to the growing number of people who have been turning to podcasts for news and entertainment. And the guests we will have on and the topics we have plannedcovering the intersection of technology, longevity and agingwill be very exciting."

The podcast topics will include: changes in Medicare for telemedicine since COViD-19, the impact on older voters in the 2020 election, the innovative tech solutions to address social isolation in seniors and a holiday gadget gift guide for the age 50+ crowd. The first podcast is a tribute to the late author (Passages) and aging icon, Gail Sheehy, who passed away on August 24 at age 83. Mary Furlong (Turning Silver Into Gold) shares her memories of her friend along with authors and friends of Gail, Ciji Ware (Landing by Moonlight, Rightsizing Your Life) and Sherri Snelling (A Cast of Caregivers). What's Next: Living Longer, Stronger, Better podcast will be available on: Anchor, Pocket Casts, Radio Public, Spotify, Spreaker, PodcastAddict, PodChaser. Google Play, iTunes and iHeartRadio and many other podcasting outlets..

According to a report from Infinite Dial 20, 55% of the U.S. population roughly 155 million people has listened to a podcast. Among those, listeners age 55+ make-up 20% of the entire podcast audience. According to Nielsen, podcast listeners are more likely to follow companies and brands on social media they hear about on podcasts and 69% agreed that podcast ads made them aware of new products or services.

About Mary Furlong Mary is the President and CEO of Mary Furlong & Associates, and is a leading authority on the longevity marketplace. She is an author, educator, and serial entrepreneur, and she has helped to guide the business and marketing strategies of leading corporations, emerging companies and nonprofits. Interested sponsors can learn more at: maryfurlong.com

About Fred Fishkin Fred is an award-winning journalist who has worked with CBS Radio, Bloomberg and NPR, and has hosted a long-running daily radio and online report on consumer technology. He also works with Princeton University and the faculty chair of autonomous vehicle engineering on a regular podcast focused on using technology to provide mobility for all. Find more of Fred's work at http://www.techstination.com and http://www.smartdrivingcar.com.

Media Contact: Mary Furlong - (925) 323-0312, 247587@email4pr.com Fred Fishkin Fishkin@techstination.com

View original content to download multimedia:http://www.prnewswire.com/news-releases/new-podcast-presents-power-player-interviews-at-intersection-of-longevity-and-technology-301132098.html

SOURCE Mary Furlong Associates

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New Podcast Presents Power Player Interviews at Intersection of Longevity and Technology - Stockhouse

The link between the foods we eat and the length of our life expectancy is firmly established. Eating healthily can bolster your defences against a host of chronic diseases, not least heart disease - a major killer worldwide. Extensive research has extolled the virtues of healthy eating.

Health bodies routinely advocate eating a diet that is full of fruits and vegetables, whole grains, nuts, fish, poultry, and vegetable oils.

For good reason too. In a study published in The Journal of nutrition, people with diets consistent with a healthy dietary pattern had a 31 percent lower risk of heart disease, a 33 percent lower risk of diabetes, and a 20 percent lower risk of stroke.

Much emphasis is placed on the foods we eat but less is understood about the frequency of our eating habits.

Speaking to the Express.co.uk, Dr Sarah Brewer, Medical Director of Healthspan and Author of Live Longer, Look Younger, shed some light on the current research in this area.

READ MORE:How to live longer: Consume this spice to reduce heart disease risk and inhibit cancer

"Restricting your calorie intake can significantly extend your lifespan, although you may argue that life quality is reduced," she said.

Unfortunately, as Dr Brewer explained, you need to restrict calorie intake to 60-70 percent of your normal daily needs to prolong your lifespan by 30-50 percent.

This can be a tall order, especially if you have a mentally and demanding lifestyle.

However, eating every other day (i.e. fasting one day, and eating what you like the next) appears to produce similar effects with health benefits starting within as little as two weeks, noted Dr Brewer.

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This insight comes from researchers writing in the journal Medical Hypotheses.

As Brewer reported, the researchers suggested this strategy might improve insulin resistance, asthma, allergies, infections, autoimmune diseases (eg asthma, rheumatoid arthritis), osteoarthritis, heart problems and menopausal symptoms.

It may also delay, prevent or improve neurological conditions such as Alzheimer's, Parkinson's and multiple sclerosis.

Rethinking your eating habits should not come at the cost of regular exercise, however.

"Exercise can partially reverse the effects of the ageing process on physiological functions and preserve functional reserve in the elderly," said Dr Brewer.

Numerous studies have shown that maintaining a minimum quantity and quality of exercise decreases the risk of death, prevents the development of certain cancers, lowers the risk of osteoporosis and increases longevity.

One notable study involving more than 10,000 men found that exercise reduced the number of age-related deaths from all causes by almost a quarter - even if exercise was not started until middle age, reported Dr Brewer.

"In particular, deaths from coronary heart disease were reduced by 41 percent and risk of stroke reduced by 50 percent," she said.

Regular exercise has also been shown to prevent diabetes, with the protective effect appearing strongest in those with the highest risk, said Dr Brewer.

"Both the Finnish Diabetes Prevention Study and the Diabetes Prevention Program found that changes in lifestyle of high-risk overweight subjects with impaired glucose tolerance reduced the risk of type 2 diabetes by 58 percent," she reported.

Furthermore, exercise appears to reduce the risk of certain cancers, especially those of the colon, rectum and uterus, she added.

According to the NHS, adults should do at least 150 minutes (two hours and 30 minutes) of moderate-intensity aerobic activity, such as cycling or fast walking, every week.

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How to live longer: How often you should eat to extend your life expectancy - Express

Date published: September 19 2020

Guenther Steiner says that, in deciding who will drive for Haas next season, he and the team are thinking beyond 2021.

The American team currently has two seats free for next year, with neither Romain Grosjean nor Kevin Magnussen being offered new deals as of yet.

With Sergio Perez and Nico Hulkenberg available, as well as a number of younger drivers, there are a number of options for the team. As many as 10, Steiner recently claimed.

There are close to 10 [options], he told Autosport.

It is amazing what is around at the moment. Thats why you see me very calm. Because there are only 20 seats, and we have got 10 potential people which could do the job, which is good.

Two of them we have got already.

Get your hands on the official Haas 2020 collection via the Formula 1 store

In the eyes of many, Perez and Hulkenberg are the two best options, with both having proved themselves to be excellent midfield drivers on the grid.

However, while they may be the best for next season, with new regulations on the horizon, Steiner is thinking ahead to beyond then.

I dont want to go through all the criteria but it needs to be a package, and we need to see what do we want to do in the future, he said.

Were not just thinking about next year. Then, if youre short on thinking, it is pretty easy: you try to get the fastest guy as quickly as possible in.

But we are thinking about the next five years after we have signed our Concorde Agreement now. So, we want to build up again, that we are getting back to the results that we had in 2018.

That takes a bit more time to think it through: financially, talent, its a lot of things coming into play. And that is where we are. As I said, we are in no hurry.

In terms of younger drivers, the team has both Pietro Fittipaldi and Louis Deletraz in its ranks. Whats more, due to the close relationship with Ferrari, Mick Schumacher and Robert Shwartzman are genuine possibilities.

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Guenther Steiner favouring longevity in driver selection | PlanetF1 - PlanetF1

Certain non-obvious daily habits can interfere with longevity and increase your risk of cancer. Oncologist Robert Thomas, who teaches in Cambridge, warned about this, reports the Daily Mail.

Image via: pixabay.com If the toast is burnt during preparation, the doctor advises against eating it. Under the influence of high temperatures in foods containing starch and sugar, acrylamide compounds are formed, which are considered toxic. They threaten DNA damage and put a significant strain on the immune system, increasing the risk of cancer. Although one burnt toast will not harm your health, it is worth considering if such a dish is constantly included in the diet.

Fresh blackberries are good anti-carcinogenic agents. However, a berry bought in a store does not have such pronounced properties, it can also contain pesticides and toxins.

Vegetable chips are not the best substitute for potato chips, the oncologist warned, since they are about as harmful. Such healthy snacks are often made from beets and carrots, where the sugar is even higher and the level of acrylamides is higher, which threatens cancer.

For cheese lovers, it is better to choose blue, it contains a lot of bacteria that are beneficial to the body. Also, the product has a positive effect on the work of the digestive tract.

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Burnt toast and vegetable chips: Oncologist named subtle habits that increase the risk of cancer and interfere with longevity - The Times Hub

Sept. 20, 1883: John Appleton (1804-1891) of Bangor, chief justice of the Maine Supreme Judicial Court, retires after serving 20 years and 11 months in that role, longer than any other chief justice in Maine history.

A New Hampshire native, the Bowdoin College graduate was admitted to the bar in that state, then moved back to Maine to practice law in Dixmont, Sebec and Bangor. He was appointed as a Maine Supreme Judicial Court associate justice in 1852, then became chief justice in 1862.

Appleton influenced the development of Maine law greatly. His treatise The Rules of Evidence, Stated and Discussed, published in 1860, set a template on that subject that became a national model. He was also noted for his embrace of free-market capitalism and opposition to government loans or tax breaks for businesses.

In December 2019, Chief Justice Leigh Saufley completes her 18th year as chief justice, a time in that office second only to that of Appleton. She announces in April 2020 that she will step down later in the year to become dean of the University of Maine School of Law. As a result, Appletons longevity record remains intact.

Sept. 20, 1993: Victoria Vicky Van Meter (1982-2008) of Meadville, Pennsylvania, who began flying airplanes at age 10, becomes at age 11 the youngest girl ever to fly across the United States from east to west when she flies a Cessna 172 from Augusta to San Diego, California, taking five days to make the trip. Her record is later broken.

The following year, at age 12, Van Meter becomes the youngest female pilot to make a trans-Atlantic flight when she files a Cessna 210 from Augusta to Glasgow, Scotland.

Van Meter later graduates from Edinboro University in Pennsylvania with a bachelors degree in criminal justice, then becomes a Peace Corps worker in Moldova, a former part of the Soviet Union. In 2008, having battled depression and resisted taking medication, she dies from a self-inflicted gunshot wound.

A statue of her in the Augusta State Airports terminal building commemorates her 1993 transcontinental achievement.

Joseph Owen is an author, retired newspaper editor and board member of the Kennebec Historical Society. Owens book, This Day in Maine, can be ordered at islandportpress.com. To get a signed copy use promo code signedbyjoe at checkout. Joe can be contacted at: [emailprotected]

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On this date in Maine history: Sept. 20 - Press Herald

Advertisers arent looking for vanilla placements anymore. What they seek is a higher engagement, top-of-the-mind recall value and the consistent reach through one medium.

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Theres hardly any property on TV other than Bigg Boss on Colors that offers this valuable assortment to brands. According to industry experts, despite being the costliest property on Indian television, brands get as high as 3X to 5X ROI in terms of media value on Bigg Boss.

Top media planners said what Bigg Boss offers isnt just high viewership because of high entertainment value, but also seamless content integration and longevity as it runs for more than three months and over 100 episodes. The upcoming season starts on October 3.

Longevity wins the race

Soumit Deb

Media experts suggest what makes Bigg Boss an attractive proposition is its longevity and entertainment value. Bigg Boss is one of the biggest properties in the Hindi Entertainment space for more than a decade now. What makes it big is obviously the celebrity anchor and the longevity of the show with 100 plus episodes. All brands associated with Bigg Boss are the ones that realise that the longevity will help them grow their viewership and increase the recall value, says Soumit Deb, General Manager, MediaCom.

What we could figure from the third-party data is that the presenting sponsor always gets 3x media value. I believe thats why most of them come back, otherwise, why anyone would come back year after year, he added.

Mahesh Shetty

Mahesh Shetty, Head, Network Sales, Viacom18, says when advertisers see that the money they have invested got 5x returns in terms of media value, it becomes a lucrative buy. He said brands like Vivo, Lays and Dabur benefited a lot last year.

Seamless content Integration

A large part of this success has to be attributed to how seamlessly integration is done without compromising with the content. Shetty said, they work on brand briefs and then have to balance the brands demand along with the viewers. Theres a lot of to and fro and we have a team as a part of the sales team which conceptualises ideas as different brands have different needs and focuses on delivering the value to the partnered brands. It is a fine balance, our objective is to deliver value to both the viewer and the advertiser and there are times when the brands come up with good ideas, he said.

Citing an example, he said Vivo wanted to amplify their phones video-recording facility, so we got one of the housemates Shefali Bagga, who happens to be a news anchor, to record edgy interviews with some of the housemates, which were recorded on the Vivo phone and the features of the phone were amplified over there. At the same time, great content was created. The ideal mix is when you make great content and at the same time amplify brand properties.

Kishan Kumar MS

Kishan Kumar MS, Chief Growth Officer and South, Head, Wavemaker India, said, Snapdeal has used Bigg Boss beautifully to leverage the offline and online audiences. It depends on how well you leverage the platform. We have seen that FMCG brands that have stories to tell with synergies to the show have benefitted. Nippon Paint was the first brand to completely redesign the Bigg Boss house for Tamil and that worked well for us, he added.

Rising number of brand associations

In the last few years, there have been some memorable brand integrations on the show. Such associations include the Vodafone caller of the week, and Appy Fizz Zone, Garnier Mens Face Wash, Clean and Dry and Maruti Suzuki Swift.

Mohit Joshi

Mohit Joshi, MD, India, Havas Media Group, says, Bigg Boss is a strong platform and has grown well over the years. The number of brand associations has increased and rightfully so. In the 2006 first season, we had extensively used Reckitt Benckiser products in the show. The integration was seamless and was very well appreciated. Over the years I have seen many more integrations happening. We had also integrated the Hyundai Eon in Big Boss' task once.

This season, Mobile Premier League is the Presenting Sponsor of the reality series and Dabur Dant Rakshak Ayurvedic Paste and Tresemme are the Powered by Sponsors.

According to Deb, the brands that are ready to invest would benefit the most with Bigg Boss. From a sponsor point of view, a lot many things happen in the house. It is not only about placements but many other things happen inside the house like a branded task. So each brand picks up elements from the house. This helps the brands recall and amplifies it. So the winner here clearly is the one who invests that kind of money on the show.

With so many sponsors up for grabs, when we asked Shetty whether there are any criteria for selecting these sponsors, he said, It depends on the category, for example, HUL is our partner. They have a plethora of brands but they associate just one. It depends on who closed the deal first for that category and at the best possible price. At times there are also categories that make a lot of sense from a content point of view for us and for those we take a call accordingly.

Info@BestMediaInfo.com

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Why brands turn to Bigg Boss despite being arguably the costliest property - Best Media Info

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EAST RUTHERFORD If things had worked out the way they were supposed to for the New York Jets, Frank Gore wouldnt have started a single game for them this season.

But a hamstring injury to LeVeon Bell in the season-opener changed things. And when the Jets host the San Francisco 49ers on Sunday at MetLife Stadium, theyll be relying on Gore to carry most of the running load against one of the best defenses in the NFL. And the 37-year-old expects to deliver.

I always prepared like I was the guy, just because you never know what happens in this league, said Gore, who is in his 16th NFL season. Thats why I go out every day on the practice field and prepare like I do. If my number gets called, I want to be ready.

It feels almost fitting that Gore will get this opportunity against his former team, the 49ers.

Gore has found a place among the greatest running backs in NFL history with a combination of durability and relentlessness. It all started with the 49ers in 2005, where he spent the first 10 years of his career.

Gore still has love for the 49ers. His profile picture on Twitter is a red and gold No. 74, with the 49ers logo on it, honoring the retirement of Joe Staley, the offensive tackle who spent so many years blocking for Gore.

Gore said this weekend that he plans to retire with the 49ers if he ever does decide to retire.

New York Jets running back Frank Gore (21) looks on prior to the game against the Buffalo Bills at Bills Stadium.[RICH BARNES/USA TODAY SPORTS](Photo: Rich Barnes, Rich Barnes-USA TODAY Sports)

But when he takes the field at MetLife Stadium, Gore will put all those feelings to the side and do everything in his power to beat his former team.

I want to win, Gore said. Especially with us coming off a loss last week. I want us to look a lot better than last week, as an offense, as a team. And thats doing whatever it takes to win. It could be the 49ers, Seattle, whatever. I just want to get a win.

The 49ers will surely be doing all they can to make it a difficult day for Gore, too. But what Gore was able to accomplish with the 49ers he had his best seasons in San Francisco, including all five of his Pro Bowl selections still lingers more than six years after he last played for the organization.

"I love Frank Gore, 49ers coach Kyle Shanahan told reporters as he prepared to play the Jets. I think he's one of the best running backs to ever play. I think he's one of the more underrated running backs to ever play. His longevity and his numbers now have finally given him a little bit more attention that is past due.

Gore passed Barry Sanders last fall, becoming the third-leading rusher in NFL history. He trails only Walter Payton and Emmitt Smith. Shanahan never coached him in San Francisco. But as a young quality control coach for the Buccaneers, Shanahan remembers watching Gores film from the University of Miami, and what he saw in 2004 left an impression even before Gore started marching toward history.

FILE - In this Dec. 18, 2005, file photo, San Francisco 49ers running back Frank Gore, left, is tackled by Jacksonville Jaguars defender Mike Peterson, right, during the second quarter of an NFL football game in Jacksonville, Fla. Gore took his first NFL snaps as a pro with the 49ers in 2005 in what seems like a lifetime ago for the NFL's third-leading rusher. It all comes full circle for the 37-year-old Gore on Sunday, Sept. 20, 2020, when his New York Jets host the team with which he began his career 16 years ago. (AP Photo/Phil Coale, File)(Photo: The Associated Press)

My first year in the league I remember watching his [film] in Tampa, just coming out of Miami just studying him, Shanahan said. I loved him then, I loved him every year. He runs so hard. The guys that run that hard very rarely can play to his age, which just shows how dedicated he is, how much of a football player he is and obviously extremely talented, but he's a special dude."

Relentlessness is one of the things that makes Gore special. Hes never liked sitting out preseason games. And at age 37, hes not particularly thrilled with the weekly maintenance plan that has him sitting out every Thursday practice as a rest day.

Jets coach Adam Gase has been a vocal supporter of Gore since he had the chance to coach him with the Dolphins in 2018. And while hell be mindful of Gores carries on Sunday, hell also knows that keeping his workload down will be easier said than done.

I have an idea, Gase said. But last time I had an idea, it just went a little sideways and we [the Dolphins] were playing Chicago, next thing I know he looked like he lost about 15 pounds in that game. I try to be smart as far as managing his carries and his reps, trying to get those other guys involved and then at the same time, you know, Frank likes to get in a rhythm so he wont like standing over there too long.

Gore had 15 carries for 101 yards for the Dolphins against the Bears that day, his 44th career game with 100 or more yards. He had his 45th and most recent 100-plus-yard last year with te Bills, going for 109 yards on 17 carries. If the Jets hope to beat the 49ers, it would help a lot of Gore could eclipse 100 yards for the 46th time in his career.

The Jets announced Saturdaythat they have signed linebacker Alec Ogletree from the practice squad to the active roster for Sunday's game. They also elevated two players to the active roster: running back Josh Adams and wide receiver Josh Malone.

Ogletree has started all 93 games he's appeared in during a seven-year NFL career, including 13 last year with the Giants. He was added to the Jets' practice squad in earlier this month and wasn't on the roster for the season-opener in Buffalo. It's unclear what role he'll play with the Jets, but he could start.

Avery Williamson ramped up his practice this week, but it's unclear if he'll be able to play after missing Week 1 with a hamstring injury. Ogletree and Neville Hewitt are the only healthy inside linebackers on the roster.

Adams and Malone have now both been elevated from the practice squad to the active roster for the second time, and will be able to return to the practice squad without passing through waivers -- one ofthe rule changes for playing this season during the pandemic.

But if the Jets want either on the active roster for a third time later this season, they won't be able to elevate them: they'll have to sign them to a player contract and they'll have to pass through waivers to return to the practice squad.

Andy Vasquezis the Jetsbeat writer for NorthJersey.com. For unlimited access to all Jets analysis, news, trades and more, pleasesubscribe todayanddownload our app.

Email:vasqueza@northjersey.comTwitter:@andy_vasquez

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NY Jets' Frank Gore, 37, gets a chance to prove he's still got it on Sunday vs. 49ers - NorthJersey.com

STEAMBOAT SPRINGS The Howelsen tunnel along the Yampa River Core that connects Yampa Street with Howelsen Hill will be closed from Monday, Sept. 21, to Thursday, Sept. 24, for scheduled maintenance.

The tunnel was built of concrete culvert sections, and the joint sealing the sections together no longer holds water. Contractors will inject an epexoy resin into the joints to reseal the area and prevent water from seeping into the tunnel.

Signs will help reroute Core Trail users to Yampa Street between Fifth and 10th streets.

Readers around Steamboat and Routt County make the Steamboat Pilot & Todays work possible. Your financial contribution supports our efforts to deliver quality, locally relevant journalism.

Now more than ever, your support is critical to help us keep our community informed about the evolving coronavirus pandemic and the impact it is having locally. Every contribution, however large or small, will make a difference.

Each donation will be used exclusively for the development and creation of increased news coverage.

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Yampa River Core Trail tunnel near Howelsen closed until Friday - Steamboat Pilot and Today

The World Health Organization (WHO) said health care workers make up about1 in6 cases of coronavirus around the world and more than a third of cases in some countries.

While health workers represent less than 3% of the population in the large majority of countries and less than 2% in almost all low- and middle-income countries, around 14% of COVID-19 cases reported to WHO are among health workers, the health agency said in a statement Thursday.

Our country is in a historic fight against the Coronavirus. Add Changing America to your Facebook or Twitter feed to stay on top of the news.

In some countries, the proportion can be as high as 35%, the WHO said, noting that COVID-19 has exposed health workers and their families to unprecedented levels of risk and thousands have lost their lives globally.

The WHO noted that its data was limited as its not possible to determine whether medical front line workers were infected in the workplace or in their community setting. The numbers could also be skewed because health workers are typically prioritized for testing.

The pandemic has also placed tremendous psychological stress on health care workers battling the virus on the front lines. In addition to the physical risk, the WHO said a recent review found one in four health workers reported experiencing depression and anxiety during the outbreak, and one in three suffered insomnia.

During a news briefing marking World Patient Safety Day, WHO Director-General Tedros Adhanom Ghebreyesus urged governments to address the threats health workers face and announced the launch of the Health Worker Safety Charter. The charter includes steps to better protect workers and improve their mental health.

The COVID-19 pandemic has reminded all of us of the vital role health workers play to relieve suffering and save lives, Tedros said. No country, hospital or clinic can keep its patients safe unless it keeps its health workers safe.

READ MOREABOUT THE CORONAVIRUS PANDEMIC IN AMERICA

UNIVERSITY OF PITTSBURGH SCIENTISTS FIND ANTIBODY THAT NEUTRALIZES CORONAVIRUS

WHEN IS THE COVID VACCINE COMING? HERES WHERE THE BEST CANDIDATES ARE RIGHT NOW.

WHO REPORTS THERE WAS A RECORD-BREAKING ONE-DAY INCREASE IN CORONAVIRUS CASES ON SUNDAY

MAJORITY OF AMERICANS FEAR POLITICAL PRESSURE WILL RUSH CORONAVIRUS VACCINE

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Health workers make up 1 in 7 reported coronavirus infections, WHO says | TheHill - The Hill

Genome Editing/Genome Engineering Market Research Report by Technology (Antisense, Crispr, Talen, and Zfn), by Application (Cell Line Engineering, Diagnostic Applications, Drug Discovery & Development, and Genetic Engineering) - Global Forecast to 2025 - Cumulative Impact of COVID-19

New York, Sept. 18, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Genome Editing/Genome Engineering Market Research Report by Technology, by Application - Global Forecast to 2025 - Cumulative Impact of COVID-19" - https://www.reportlinker.com/p05953106/?utm_source=GNW

The Global Genome Editing/Genome Engineering Market is expected to grow from USD 4,901.67 Million in 2019 to USD 14,012.67 Million by the end of 2025 at a Compound Annual Growth Rate (CAGR) of 19.13%.

Market Segmentation & Coverage:This research report categorizes the Genome Editing/Genome Engineering to forecast the revenues and analyze the trends in each of the following sub-markets:

Based on Technology, the Genome Editing/Genome Engineering Market studied across Antisense, Crispr, Talen, and Zfn.

Based on Application, the Genome Editing/Genome Engineering Market studied across Cell Line Engineering, Diagnostic Applications, Drug Discovery & Development, and Genetic Engineering. The Genetic Engineering further studied across Animal Genetic Engineering and Plant Genetic Engineering.

Based on Geography, the Genome Editing/Genome Engineering Market studied across Americas, Asia-Pacific, and Europe, Middle East & Africa. The Americas region surveyed across Argentina, Brazil, Canada, Mexico, and United States. The Asia-Pacific region surveyed across Australia, China, India, Indonesia, Japan, Malaysia, Philippines, South Korea, and Thailand. The Europe, Middle East & Africa region surveyed across France, Germany, Italy, Netherlands, Qatar, Russia, Saudi Arabia, South Africa, Spain, United Arab Emirates, and United Kingdom.

Company Usability Profiles:The report deeply explores the recent significant developments by the leading vendors and innovation profiles in the Global Genome Editing/Genome Engineering Market including Creative Biogene, Crispr Therapeutics, Editas Medicine, Epigenie, Eurofins Scientific SE, Genscript Biotech, Horizon Discovery Group PLC, Integrated DNA Technologies, Inc., Intellia Therapeutics, Inc., Lonza Group AG, Merck & Co., Inc., New England Biolabs, OriGene Technologies, Inc., Oxford Genetics Ltd., Precision Biosciences, Sangamo Therapeutics, Synthego Corporation, Thermo Fisher Scientific Inc., Transposagen Biopharmaceuticals, Inc., and Vigene Bioscience Inc..

FPNV Positioning Matrix:The FPNV Positioning Matrix evaluates and categorizes the vendors in the Genome Editing/Genome Engineering Market on the basis of Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) that aids businesses in better decision making and understanding the competitive landscape.

Competitive Strategic Window:The Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies. The Competitive Strategic Window helps the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. During a forecast period, it defines the optimal or favorable fit for the vendors to adopt successive merger and acquisition strategies, geography expansion, research & development, and new product introduction strategies to execute further business expansion and growth.

Cumulative Impact of COVID-19:COVID-19 is an incomparable global public health emergency that has affected almost every industry, so for and, the long-term effects projected to impact the industry growth during the forecast period. Our ongoing research amplifies our research framework to ensure the inclusion of underlaying COVID-19 issues and potential paths forward. The report is delivering insights on COVID-19 considering the changes in consumer behavior and demand, purchasing patterns, re-routing of the supply chain, dynamics of current market forces, and the significant interventions of governments. The updated study provides insights, analysis, estimations, and forecast, considering the COVID-19 impact on the market.

The report provides insights on the following pointers:1. Market Penetration: Provides comprehensive information on the market offered by the key players2. Market Development: Provides in-depth information about lucrative emerging markets and analyzes the markets3. Market Diversification: Provides detailed information about new product launches, untapped geographies, recent developments, and investments4. Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, and manufacturing capabilities of the leading players5. Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and new product developments

The report answers questions such as:1. What is the market size and forecast of the Global Genome Editing/Genome Engineering Market?2. What are the inhibiting factors and impact of COVID-19 shaping the Global Genome Editing/Genome Engineering Market during the forecast period?3. Which are the products/segments/applications/areas to invest in over the forecast period in the Global Genome Editing/Genome Engineering Market?4. What is the competitive strategic window for opportunities in the Global Genome Editing/Genome Engineering Market?5. What are the technology trends and regulatory frameworks in the Global Genome Editing/Genome Engineering Market?6. What are the modes and strategic moves considered suitable for entering the Global Genome Editing/Genome Engineering Market?Read the full report: https://www.reportlinker.com/p05953106/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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Genome Editing/Genome Engineering Market Research Report by Technology, by Application - Global Forecast to 2025 - Cumulative Impact of COVID-19 -...

Early in the morning of August 31st, 2020, as Salisha Odum owner/operator of Salishas Delicious Organic Produce, readied her daughter for online school, they both responded immediately to the sound of a plane flying close, at low altitude, to their house and fields.

The plane flew back and forth several times over the course of an hour, and by the third pass, Salisha said the unknown chemicals settled on the land.

Thats when I smelled the chemicals. And then I kind of got sick and dizzy and you know, wasnt feeling good at that time either we were out taking videos because what had happened in the past we wanted to get some footage if we could, Odum said.

Salishas photo records show a plane she traced back to Frey Spray LLC.

The Ally contacted Frey Spray owner Jerry Frey. He denied the allegation.

We werent flying over her house and we werent spraying over her house. Her field was a long ways away and no one else complained next door, Frey said in a phone interview.

Frey Spray LLC

Jerry Frey and Frey Spray are busy, with upwards of seven farm contracts a day, covering 600 acres on average, flying every day during the growing season.

They also spray 11,000 acres for the Churchill County Mosquito, Vector, and Noxious Weed Abatement District. The yearly contract for combatting mosquitos nears $100,000 annually.

Jerry is on the frontline of combatting vector-borne illness like malaria, dengue fever, and West Nile virus. If Zika virus were to arrive in Nevada, Jerry would probably be among the first to know.

Records obtained through the Nevada Department of Agriculture show that the Frey plane was spraying two pesticides on August 31: Fastac CS Insecticide and Yuma 4E Insecticide. Fastac CS is a class 3A insecticide, meaning in part that it is a pyrethroid.

As well as the effects suffered by Salisha, in more recent studies (by the Agency for Toxic Substances and Disease Registry), this class of insecticides are shown to be possibly carcinogenic at higher levels of exposure. And the Yuma 4E in the class 1B, comes with warnings on its label:

Harmful If Absorbed Through Skin. Causes Moderate Eye Irritation Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application.

Frey Spray works as far afield as Battle Mountain, Minden/Gardnerville, Yerrington, Winnemucca, and Lovelock.

I asked Jerry Frey about sprays he was using on that day Salishas Delicious Organic Produce farm was allegedly sprayed: Yeahthat would take a long time to do (to describe) We use a horrible variety of that we go with whatever the EPA approves and calls for.

How many agents does Frey use?

Probably close to 100. We try to keep it confined to just a few and thats about as few as we can get; we could enlarge it and go to 200.

We asked if Jerry had any concerns about working so closely with all of these chemicals.

Theyve eliminated a lot of the caustic chemicals we just have to spray more often now, because they just left very weak products on the market. So everyone just has to spray more often. There never used to be this much spraying . . . So its just a matter of who controls the lawmaking, how far they can think ahead.

Jerry addresses permethrins (pesticides naturally derived from chrysanthemums) and pyrethroids (the chemically derived pesticides used in industrial agriculture).

Before Christ they discovered that certain extract other chrysanthemum plants killed worms real good, killed a lot of bugs real good. So of course were in the day and age we are now we reverse engineer it and we manufacture it by the gallon, thousands of gallons and a little bit does a lot.

And if youre sitting on your kitchen table in the gallon jug of this falls over and starts glugging out It could run onto a baby, a brand new born baby and not harm it at all. The salt shaker full of salt is more toxic than what is in that jug when we lean on those products a lot. Theyre called pyrethroids. And permethrins. The pyrethroids are the reverse-engineered. Weve been doing it for years Its just been a wonderful product. And they took a lot of nasty products off the marketthe press made them sound more nasty than they were but we dont care. So [the press has] a job to do. Alarms to ring anyway.

Salishas Delicious Organic Produce and the Challenges faced by Organic Farmers

Churchill County is a leading agricultural region in the state and home to 672 farms and ranches. Nearly $200 million in agricultural products are sold a year. Sixty-three percent of the farms are smaller than 49 acres.

Salisha is/was one of two certified organic farmers in the county at the time of press and is literally surrounded by industrial operations that hulk in size compared to the scale of her organic farm.

According to the USDA, 4 percent of all food sales in the nation are organic.

To achieve United States Department of Agriculture (USDA) organic certification, farmers must pass regular tests through the course of three years, showing their soil has no herbicide or pesticide residues. Farmers seeking organic certification have to keep their farms, records and practices open to examining inspectors throughout the entire course of the three-year process.

Organic crop and production practices are based on: soil building through composting; use of organic non-genetically modified seeds; crop rotation to keep soil biomes healthy and diverse (as well as to help mitigate pests); pest management relying on the PAMS (prevention, avoidance, monitoring, and suppression) strategy, which is achieved through natural means only, except for a small list of USDA-approved synthetic pesticides.

According to the USDA, organic production is achieved through a combination of practices which promote ecological balance, and conserve biodiversity [while] avoiding use of synthetic fertilizers, sewage sludge, irradiation, and genetic engineering.

All of this with the aim to sustain and regenerate the very systems that raise nutritious wholesome food.

Conventional farming, also known as industrial agriculture, became more popular and widely practiced after WWII, largely in efforts to drive food yields and production up.

Synthetic chemical insecticides and pesticides are permitted and regulated through the Environmental Protection Agencys guidelines. Genetically modified organisms, irradiation, and the use of sewage sludge are permissible in the practices of conventional farming.

Monocropping is also part of the industrial system, allowing for huge yields and productions of produce for human consumption, as well as fodder crops for animal feed. Many of the animals to which the fodder is fed are confined in large-scale farming operations (also known as CAFOs: confined animal farming operations), where they are living in unnaturally dense containment.

The animals are fed grain diets heavily supplemented by hormones for quick fattening and medications to stave off infections, sicknesses and diseases wrought by living in such unnatural proximity.

To treat industrial-scale fields, heavy and specialized machinery like giant tractor systems, airplanes, and helicopters are used to enable large-scale operations.

These practices were introduced with the goal to feed the world and eradicate hunger.

On June 16, 2016, Salisha said Frey Spray wrongly treated her property with glyphosate, an active ingredient in the herbicide Roundup. Salisha sued Frey; and the parties settled out of court.

Weve had problems with [Salisha] before and had to go to court. And we never were proven to be wrong there, said Jerry Frey about the glyphosate incident.

Salisha recalls the preliminary court hearing.

Judge Stockard advised the Freys that they were not going to win in court, because we had forensic evidence . . . [positive tests for glyphosate] from the Nevada Department of Agriculture, and so they decided that they would go ahead and settle out of court and thats what we did.

It was only in late 2019 that Salisha was recertified USDA organic, after enduring that three-year period of glyphosate residues diminishing enough in her soils to regain the organic stamp.

Spraying these pesticides on a certified organic farm is a catastrophic event. Testing is underway at Salishas farm, but if these chemicals are present, she would lose her certification.

If Salisha were a conventional farmer, she would have to wait 30-60 days after insecticidal spraying for human consumption of these crops.

As an organic farmer, these same crops have to rest for at least 120 days for the current round of insecticide residue to diminish enough into the soil. To be organically saleable, the USDA must test the soil.

All of this disruption happened with only a couple weeks remaining at Salishas primary farmers market in Reno.

Salishas other main outlet, the Fallon Food Hub, now has a serious shortage of organic vegetables.

Planning for Next Season

As Salisha thinks ahead to her next growing season, she awaits the latest round of test results to decide her next course of action regarding the alleged spray-over of her farms, which could mean possible litigation.

Now are the days of big harvest. Many crops are coming in, and lots of sales will be made. Meanwhile, Salishas turned the water off. She has chalked-up the rest of 2020 as a loss.

A lot of work I put in is pretty much wasted Its my preference not to buy food at the store if I dont have to, because if I can go out there and know whats in the product and its got my work in there too, you know, its even better I agree with my customers that my food tastes the best. I truly believe that thats what got me into this in the first place, is wanting to have good food.

All Im really worried about is being an organic farmer and feeding people good food. I mean, thats what I do in life, you know.

Salishas Delicious Organic Produce in Churchill County is a microcosm of organic farming in the United States. Clouds of prohibited chemical agents surround organic farms. Salisha says one farmers gold is another farmers poison.

I mean, if you look at the list of the toxicity on this stuff, its utterly crazy that anybody would even think about putting it on food this is a problem that I know that the United States is facing and its probably not just my farm whos has to go through things like this. And so Im hoping that maybe we can just bring awareness to whats actually going on, and maybe also bring awareness to [the sprayers] as to the effects that it has on people

Once youve been actually exposed to these chemicals, then you can honestly say, I know this is not good for me.

This stuff is poison. And I dont understand why today we call things that are poison, not poison. Back when I was a kid, we put a skull and crossbones on poison. You dont see that anymore. And to me, thats a scary thing.

Anthony Postman writes about agriculture, sustainability and the environment for the Ally. Support his work.

Originally posted here:
Alleged Pesticide Spraying of organic farm in Fallon highlights the differences between organic and conventional agriculture - The Sierra Nevada Ally

Organoids, which originate from stem cells, are a tool with great potential for modeling tissue and disease biology. The idea is to build miniature tissues and organs that accurately resemble and behave like their real counterparts. But there have been limitations to their development. A new study has taken organoids a step further by inducing intestinal stem cells to form tube-shaped epithelia with an accessible lumen and a similar spatial arrangement of crypt- and villus-like domains to that in vivo. These mini-intestines also retain key physiological hallmarks of the intestine and have a notable capacity to regenerate.

The work is published in Nature in the paper titled, Homeostatic mini-intestines through scaffold-guided organoid morphogenesis.

Organoids could complement animal testing by providing healthy or diseased human tissues, expediting the lengthy journey from lab to clinical trial. Beyond that, organoid technology may hold promise, in the long-term, to replace damaged tissues or even organs in the future. For example, by taking stem cells from a patient and growing them into a new liver, heart, kidney, or lung.

So far, established methods of making organoids come with considerable drawbacks: stem cells develop uncontrollably into circular and closed tissues that have a short lifespan, as well as non-physiological size and shape, all of which result in overall anatomical and/or physiological inconsistency with real-life organs.

Now, scientists from the group led by Matthias Ltolf, PhD, professor at EPFLs Institute of Bioengineering, have found a way to guide stem cells to form an intestinal organoid that looks and functions just like real tissue. The method exploits the ability of stem cells to grow and organize themselves along a tube-shaped scaffold that mimics the surface of the native tissue, placed inside a microfluidic chip.

The researchers used a laser to sculpt the gut-shaped scaffold within a hydrogel, a soft mix of crosslinked proteins found in the guts extracellular matrix supporting the cells in the native tissue. Aside from being the substrate on which the stem cells could grow, the hydrogel thus also provides the form or geometry that would build the final intestinal tissue.

Once seeded in the gut-like scaffold, within hours, the stem cells spread across the scaffold, forming a continuous layer of cells with its characteristic crypt structures and villus-like domains. Then came a surprising result: the scientists found that the stem cells arranged themselves in order to form a functional tiny gut.

It looks like the geometry of the hydrogel scaffold, with its crypt-shaped cavities, directly influences the behavior of the stem cells so that they are maintained in the cavities and differentiate in the areas outside, just like in the native tissue, said Ltolf. The stem cells didnt just adapt to the shape of the scaffold, they produced all the key differentiated cell types found in the real gut, with some rare and specialized cell types normally not found in organoids.

Intestinal tissues are known for the highest cell turnover rates in the body, resulting in a massive amount of shed dead cells accumulating in the lumen of the classical organoids that grow as closed spheres and require weekly breaking down into small fragments to maintain them in culture. The introduction of a microfluidic system allowed us to efficiently perfuse these mini-guts and establish a long-lived homeostatic organoid system in which cell birth and death are balanced, said Mike Nikolaev, a graduate student and the first author of the paper.

The researchers demonstrated that these miniature intestines share many functional features with their in vivo counterparts. For example, they can regenerate after massive tissue damage and they can be used to model inflammatory processes or host-microbe interactions in a way not previously possible with any other tissue model grown in the laboratory.

In addition, this approach is broadly applicable for the growth of miniature tissues from stem cells derived from other organs such as the lung, liver, or pancreas, and from biopsies of human patients. Our work, explained Ltolf, shows that tissue engineering can be used to control organoid development and build next-gen organoids with high physiological relevance, opening up exciting perspectives for disease modeling, drug discovery, diagnostics, and regenerative medicine.

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Intestinal Organoid Built That Looks and Functions Like Real Tissue - Genetic Engineering & Biotechnology News

On Sept. 15, Dr. Frances Arnold, a Nobel Laureate in Chemistry and the Linus Pauling Professor of Chemical Engineering at California Institute of Technology, gave the fall John R. and Donna S. Hall Engineering Lecture to over 700 participants over Zoom.

The lecture covered the concept of directed evolution, for which Arnold was awarded the 2018 Nobel Prize in Chemistry. Directed evolution uses lab technologies that create mutations in a pre-selected gene. These genes are then used to manufacture the mutated enzymes, which are then tested for function. Enzymes that help facilitate the reaction are selected and the process continues until the scientist is satisfied with the results.

The Hustler spoke with Dr. Frances Arnold on a Sept. 15 Zoom call about how she overcomes roadblocks, what inspires her and her advice to students.

Vanderbilt Hustler: What is a concept that still amazes you to this day?

Dr. Frances Arnold: Evolution, I think its amazing that such a simple engineering process can solve such complex problems. Were just at the beginning of this whole idea that you can reprogram the biological world, and use evolution to do it. Its mind-boggling. Youre lucky youre young. Youre going to see such incredible advances, such amazing things that you can do with biology.

When you face a roadblock in a project, what is the first thing you do?

It depends how big the roadblock is. If its an important problem, and Ive got to get over it, I find other ways to solve the same problems. Just as often I say, its not really worth getting over that roadblock, lets turn right and see whats over there.

Especially for engineers, this is one of the treasures of being an engineer. Were trying to make things that nobody has made before. Were trying to understand where we can go with, say, reprogramming the biological world. So, if you cant do one thing, there are 500,000 other things that you can do, so I think its important to adapt to roadblocks.

Could you talk about what motivated you to go into chemical engineering? You got your undergraduate degree in mechanical engineering and aerospace engineering at Princeton; what guided you after you had that strong foundation?

When I was a mechanical engineer, I wanted to engineer the most complicated things on the planet, and to me, that was an airplane or rocket ship. I took this job in Brazil and was looking at ethanol fuels and engineering something like biofuels. I realized that human engineering complexity is the tiniest fraction of the complexity of the biological world and not nearly as elegant. I love how a bird flies. There are very different solutions to the same problem, but the biological solutions are so amazing.

So, I decided to go into chemical engineering as a graduate student, mainly to try to do biofuels research, but of course, that was the end of that. Reagan was the new president. Cars were getting long again, and no one cared about energy efficiency. But it was the beginning of the DNA revolution, so I said, there is a whole new world of biological engineering that Im going to be part of. Chemical engineering was a great way to combine chemistry, biology and engineering.

At that time, was chemical engineering fairly separated from the biological sciences?

Chemical engineering has a long history of dealing with biological processes, but they werent doing it using genetic engineering, they were doing it at the process design level ethanol plants and agriculture and food science and things like that. But what happened starting in the later [19]70s and early [19]80s is that these new techniques of recombinant DNA technology started to become available.

I and other people realized that you could solve engineering problems at the level of the catalyst. If you could design a better catalyst, you could solve all sorts of process problems. We took the long history of chemical engineering and grew this new protein engineering out of it.

What do you see as the future of the enzymes you are making?

I dream of the day that all the synthetic chemists will be replaced by bacteria. (laughs) It makes me popular in the chemistry circles. Think about it, if you could just genetically encode all these transformations, you could take renewable resources to anything you want.

You worked at the forefront of the variety of disciplines, chemistry, biology, engineering as well as agriculture. Is there anything you are more interested in learning more about?

Im learning more about everything everyday. I take on new jobs, Im on the board of directors of Alphabet [Google parent company], so Im learning about antitrust suits. The world is a fascinating place. Theres lots of science, but theres lots of other interesting and important things to learn about. Im always listening to seminars and getting ideas, it never stops.

Beyond science, in college, what were some of the things that formulated the perspectives you have today?

That was my problem. I became a mechanical engineer because that had the fewest number of requirements. Then I could take Russian, Italian, French, economics and development. At Princeton, its a very liberal arts school, but also a good engineering school. I was able to learn a lot of different things and explore different ideas.

I think thats very important as a young person because you never know where your inspiration will come from. I also took a lot of time off. I lived in Spain, Italy, Brazil. You never know when something is going to be useful to you later on.

One problem with the educational system is that it is more eye-closing than eye-opening.

How are you able to go beyond calculations and keep an open mind in the sciences and engineering?

All I have to do is remember all the people who told me that what I was doing was a total waste of time. One group said it was impossible; another it wasnt worth doing anyway. These were top scientists, and they really thought they knew. So, I think we all should be humble in thinking what is worth doing and thinking we know the answers because all sorts of crazy surprises come up.

[Students] go and think everything is known. Will there be room for me? Will I be able to make fundamental advances? I felt that same way when I was an undergrad and yet there is so much that is unknown. There is so much gold out there to discover and uncover if you dont close your eyes to it. One problem with the educational system is that it is more eye-closing than eye-opening.

One problem with the educational system is that it is more eye-closing than eye-opening.

What has been your favorite class to teach?

I love teaching my biomolecular engineering class. I have a debate with a rational designer, another faculty member at Caltech, who rationally designs complex molecules and I am the evolutionist. We just throw tomatoes at each other across the room, and students love it. They see the debate in real-time and then they have to make a decision of who is right and who is wrong. Are they both right? When do I use one method versus the other? Thats a fun one.

Do you look more to biology or chemistry when facing a problem?

It really depends. If we are looking for new chemistry to do a chemical reaction that a human has invented, you start with chemistry. What is the mechanism? Is there a protein that looks remotely like this? So, you are inspired by the chemistry. On the other hand, if you want to understand how evolution works, there is no chemistry in that. It is much more in the biology side.

I run a big research group now and almost all the problems are brought in by students and postdocs. My job is to be an editor of ideas rather than the generator of ideas. They are all going to have their own training and way of looking at it and I try not to close their eyes.

At what point did you become interested in preserving the environment?

I was already interested in alternative energy coming out of college. That was part of the environmental problem, but it was more about stability and sustainability. How can we become independent from the Middle East? So, it was also political. As my career has gone on, I see the tremendous destruction that we are doing to the planet. It just becomes worse and worse, so I have become much more interested in trying to limit environmental degradation.

How are you able to carry out such wide-ranging projects?

They are not my ideas. The insect pheromone (Provivi) was my former students who said, I want to take these methods I learned at Caltech and use them on a really important problem. So, that came out of that. That is the wonderful thing about having a technology that is simple to use. Directed evolution is really simple and fundamentally powerful.

All sorts of people will use it for really interesting things, and then I can take at least some tiny amount of credit. Evolution is everything in the biological world. It is not surprising that it has many applications in biotechnology.

How did you get interested in teaching and what inspires you to continue teaching?

I wanted to have no boss. That was the driving force to get me into academics. I have had lots of jobs over my lifetime, and the one thing I really didnt like was having a boss. I went into academics so that I could do what I was interested in. It is a lot of responsibility because you have to do something interesting, otherwise you get booted out.

I wanted to plot my own course. I probably wouldnt have chosen to teach, but I really like working with grad students. I like working with a team and I learned how to do that over the course of my career, so that teaching became more enjoyable as I got better at it.

Do you have advice for undergrad students pursuing engineering or chemistry?

Id like them to know that the horizon is wide open. The field is wide open. There is so much more to do and discover. It is a great way to use your creativity to solve big problemsto do something good for the planet.

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Q&A: Nobel Laureate in Chemistry Dr. Frances Arnold speaks to The Hustler about her inspiration and advice to students - The Vanderbilt Hustler

How seriously does one take Dr Li-Meng Yan? And how seriously does one take the paper Unusual Features of the Sars-CoV2 Genome Suggesting Sophisticated Laboratory Modification Rather Than Natural Evolution and Delineation of its Probable Synthetic Route, published by her and co-authors, under the aegis of the Rule of Law Society and the Rule of Law Foundation, New York, on September 14? As the title suggests, the paper claims the coronavirus was man-made, in a laboratory.

The paper was uploaded on open-source research repository Zenodo, run by CERN, and was reported by Hindustan Times on Wednesday (bit.ly/33uFyy4). It wasnt as widely reported as Dr Yans comments in Loose Women, a segment of a TV show hosted by a UK TV channel, on which she pretty much said the same thing, albeit without any of the scientific arguments -- unsubstantiated ones -- presented in the paper.

Heres what that paper claimed:

One, ZC45, a bat virus, or a closely related variant or mutant, bears a striking similarity with Sars-CoV2, as shown by genome sequencing, with a 94%-100% similarity of key viral proteins.

The spike protein of Sars-CoV2 is essentially a trimer (essentially three parts) each of which has an S1 and S2 part with a furin cleavage site at the boundary between the two. Other research has already established that the human cellular enzyme furin cleaves, or breaks, the S1 and S2 unit at the cleavage site, and that the S1 unit then attaches to the ACE receptor, another protein found on the surface of most human cells. This binding then facilitates the entry of the viral protein into human cells. The virus ability to bind with the receptor, and the presence of the cleavage site that responds to a cannon human enzyme, are the reasons Covid-19 is as infective as it is.

Click here for complete coverage of the Covid-19 pandemic

Both the furin cleavage site, and the binding ability of the spike protein with the ACE2 receptor arent natural, the paper argued.

In their preface to this scientific hypothesis, the authors also claim that the process of creating such a virus in a laboratory could take only six months. They ask for further research and investigation into the origin of the virus. Even if their hypothesis is subsequently proven erroneous, this is a recommendation that no can argue with the origin of the virus needs to be investigated, not so much to assign blame (although there will be some that too), but to prepare for the next virus and the next pandemic.

Dr Yan, currently in the US, where she fled to in late April, is a virologist who used to work at the University of Hong Kong School of Public Health, and who has for long claimed that China knew of the virus and the fact that human-to-human transmission of the infection was happening, long before it let on. Her claims on the virus being man-made are more recent.

Interestingly, a March paper in Nature titled The Proximal Origin of Sars-Cov2, authored by Kristian G Andersen of Californias Scripps Research Institute, argued, again picking on the same two distinctive features of Sars-CoV2, that the virus was natural. The viral protein showed a high affinity to bind with the receptor, they said, but this interaction wasnt ideal or optimal. In plain English this meant that if anyone had set out to engineer the virus, they would have picked the ideal binding relation, not just another optimal one. The paper also said that there were other coronaviruses that had similar cleavage sites and that this wasnt unique to Sars-CoV2.

However, the two papers differ in one significant aspect. The one published in Nature said the genetic data irrefutably show that Sars-CoV2 is not derived from any previously used virus backbone. Dr Yans said (again, without substantiation that) a genomic sequence analysis reveals that ZC45, or a closely related bat coronavirus, should be the backbone used for the creation of Sars-CoV2.

Also read|Over 5,000 Indians died in West, East Asian countries amid Covid-19 pandemic: Govt informs Parliament

Dr Yans claims are also being seen through a political lens, with scientists in the US pointing out that the two non-profits that published the paper were linked to Steve Bannon, former Trump adviser and former executive chairman of the far-right Breitbart News, casting aspersions on the studys findings.

Clearly, only further research and investigation can shed light on the origin of the virus which has thus far infected 29,927,685 and killed 942,564 around the world. India ended Wednesday with 5,115,846 cases and 83,230 deaths.

But as Vivek Wadhwa, a columnist for this paper, a top technology thinker, and distinguished fellow at Harvard Law Schools Labor and Worklife Program, said in a recent article in Foreign Policy: If genetic engineering wasnt behind this pandemic, it could very well unleash the next one. Thats because, genetic engineering with all its potential for good and bad has become democratised, Wadhwa wrote.

Thanks to a technological revolution in genetic engineering, all the tools needed to create a virus have become so cheap, simple, and readily available that any rogue scientist or college-age biohacker can use them.

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Covid-19: What you need to know today - Hindustan Times

The Boston Cannabis Board yesterday approved a proposal by the city's first medicinal-marijuana dispensary, on Milk Street, to add recreational pot to its offerings and approved a number of proposed pot shops from East Boston to Roslindale.

The votes by the board do not mean the shops can now open - they still need to win approval from the Massachusetts Cannabis Control Commission, which can prove a lengthy process.

However, Patriot Care, which won city approval for its medical dispensary at 21 Milk St. after promising it would not seek to add "adult use" products, will get an expedited review for its shop because it already has approval to sell medical marijuana.

In its vote yesterday, the city board set several conditions on its approval, including that the new shop sell recreational pot only on an appointment basis for its first six months and that it would have to return to that model if, starting in the seventh month, lines start forming outside. Also, the shop can't sell "pre-rolled cannabis products," has to set a minimum order of $35, and has to include educational information about marijuana in each products.

Also yesterday, the board approved:

The board rejected a proposal by Dragon Vapors, LLC for a pot shop at 354-358 Chestnut Hill Ave. in Brighton and deferred until October a vote on a proposal by New Dia LLC for a pot shop that would share space in the building housing the Cask and Flagon across from Fenway Park.

The board approved a proposal by Beacon Compassion, Inc. for a medical dispensary at 1524 VFW Parkway in West Roxbury - it would go in the basement of the building that already houses a liquor store and a sex-toys shop.

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Recreational pot wins nod in Downtown Crossing and across the city - Universal Hub

Its early days, says the Good Food Institute (GFI), but microbial fermentation is rapidly emerging as the third pillar in the alternative protein industry [alongside cell-cultured and plant-based]," attracting $435m in investment capital in 2020 alone.

Right now, producing protein whether from peas and soybeans or cows and chickens is resource-intensive and time-consuming, requiring large amounts of land, energy and water, says the GFI, which has just released a 72-page reporton fermentation in the alternative protein industry, arguing that itspotential is still largely untapped.

Put another way, it takes years to grow animals, and months or years to grow plants, while microbes can double their biomass in a matter of hours, as Natures Fynd CEO Thomas Jonas recently observed: Microbes are pretty damn efficient. They make great protein and they do it really fast.

Many microorganisms also offer innately high protein content (over 50% by dry weight) coupled with extraordinarily fast and self-sufficient growth, requiring only simple and inexpensive nutrient feedstocks, noted the GFI.

Fermentation-based products can also be manufactured from a distributed network of local production facilities using a fraction of the land, water, and inputs required to raise and feed animals with the added appeal of consistent quality, a lack of price volatility, and security of supply (plus it does not require killing animals on an industrial scale).

While many food ingredients, from enzymes (chymosin, a coagulating enzyme used in cheese production) to sweeteners (Reb M), vitamins (B12, Riboflavin), and colors (beta carotene) have been made via microbial fermentation for years, investment in a new wave of fermentation players focused on the alternative protein industry has exploded over the past two years.

Approaches vary, with some startups using synthetic biology (so-called precision fermentation) to write DNA sequences that can be inserted into microorganisms to instruct them to produce substances currently produced by mammals, from whey and casein proteins (Perfect Day), egg white (Clara Foods), and collagen (Geltor) to proteins found in human breast milk (Triton Algae Innovations).

Other are deploying precision fermentation to produce components that are found in plants, but can be produced more efficiently via fermentation. For example, Impossible Foods uses a genetically engineered yeast strain to produce its flagship meaty-tasting and red-colored ingredient leghemoglobin - heme - which is found in nodules attached to the roots of nitrogen-fixing plants such as soy.

A third group of companies (using so-called biomass fermentation) such as Natures Fynd,Meati Foods, Brewed Foods (Plentify), Air Proteinand Noblegen are growing naturally occurring organisms from protists and bacteria to extremophiles that are inherently high in protein.

Globally, fermentation companies devoted to alternative proteins received more than $274m in venture capital funding in 2019 and $435m in the first seven months of 2020 from investors such as Bill Gates-backed Breakthrough Energy Ventures, Temasek and Horizons Ventures to major CPG and ingredients players such as Kellogg, ADM, Danone, Kraft Heinz, Mars and Tyson.

By mid-2020, 44 fermentation companies focused on alternative proteins had formed around the globe, while several of the worlds largest food and life science companies, including DuPont, Novozymes, and DSM, have also been developing fermentation-derived product lines and solutions tailored to the alternative protein industry, said GFI.

But they're still just scratching the surface, argued report authors Dr Liz Specht and Nate Crosser.

While fermentation has a rich history of use in food, as the modern era has demonstrated, its innovative potential is still largely untapped.

The vast biological diversity of microbial species, coupled with virtually limitless biological synthesis capabilities, translates to immense opportunity for novel alternative protein solutions to emerge from fermentation-based approaches.

Fermentation is a key means of producing animal-origin-free growth factors for cell-cultured meat production, with firms such as ORF Genetics, Richcore, and Peprotech now working in this space.

While some of the strain development work to identify and optimize microbes with potential in this segment uses tools such as gene editing and genetic engineering, noted the GFI, vast progress is also possiblethrough simple adaptation and breeding strategies powered by advanced genomic insights.

The urgency of the moment calls for bold research to explore novel hosts that could significantly outperform the incumbents.

More work is also needed to identify more cost effective or sustainable feedstocks (for the microbes) via converting waste products or agro-industrial byproducts into high-quality protein biomass, says the GFI, noting that the extremophile microorganism developed by Natures Fynd, for example, exhibits wide metabolic flexibility and therefore suitability to diverse feedstocks.

The organism used byAir Protein,meanwhile, uses components found in the air - notably carbon dioxide as feedstock.

This is just the beginning: The opportunity landscape for technology development is completely untapped in this area. Many alternative protein products of the future will harness the plethora of protein production methods now available, with the option of leveraging combinations of proteins derived from plants, animal cell culture, and microbial fermentation.

Dr. Liz Specht, associate director of science and technology, The Good Food Institute

But what about price?

According to the GFI, there is reason to believe that fermentation can achieve price parity with most products through a combination of approaches including increasing scale, improving volumetric productivity (better yields), and prolonging continuous bioprocessing (the longer a process runs continuously at its peak in steady-state growth, the more efficient the overall run will be because the cells are continuously harvested from their maximum productivity).

Fermentation is not just valuable in its own right, offering competitive prices, unparalleled functionality and scalability, and validated mechanisms for establishing and ensuring safety; it stands to revolutionize the entire alternative protein industry, with spillover applications in both plant-based products and cultivated meat.

In 2019, fermentation companies raised over 3.5 times more capital than all cell-cultured meat companies combined.

One aspect of the technology that is less explored in the report is consumer perception, which is less of an issue for companies using microbes to produce ingredients consumers already recognize such as whey or collagen, but could present novel challenges for companies making new-to-the-world ingredients, as Lever VC managing partner Nick Cooney told FoodNavigator-USA in a recent interview.

Consumer acceptance is definitely something we think about in the alternative proteins space when were evaluating companies, and I do think there will be an increased challenge for companies producing novel proteins.

Clearly, bacteria-sourced protein is not something youd find in Grandmas kitchen cupboard, Brewed Foods co-founder Dr Jonathan Gordon, told Food Navigator-USA.

But its not some kind of sci-fi fantasy either, he stressed:The notion of consuming bacteria has become very well established thanks to probiotics, although in our case, the bacteria are not live, but are fully deactivated, so theyre entirely dead, and non spore-forming.

KarunaRawal, CMO at Natures Fynd, added: What we found was that consumers just want to know what it is [the protein source], they dont like it when companies cloud things in[euphemistic]language, and we dont want to confuse anyone.

But Id say were in a different time to when Quorn[a soil micro-organism described on pack as mycoprotein]came to market and since then, the notion of good bacteria, and fermented products have become very mainstream and the landscape has changed.

The GFI breaks the market down into three segments:

Perfect Day,a startup producing milk proteins via microbial fermentation (minus the cows), recently expanded its Series C round from a previously-announced $140m, up to $300m through a new tranche led by CPP Investments and bolstered by long-time supporters Temasek and Horizons Ventures.

The cash injection -bringing its cumulative funding to over $360m -was announced as Berkeley, Calif.-based Perfect Day revealed a series of incremental improvements in recent months enabling it to increase the efficiency of its production process, substantially reducing costs two years ahead of expectations.

While Perfect Day is a b2b company, it recently moved into the b2c space via spinoff The Urgent Company, which is focused on consumer brands, beginning with animal-free ice cream Brave Robot.

Plentify a novel protein sourced from a strain of bacteria that naturally produces high levels of protein is more efficient to produce than plant-based proteins, and compared to animal husbandry, is ludicrously efficient,"claims Brewed Foods co-founder Dr Jonathan Gordon.

The obvious advantage here is the incredible compactness of production. You can basically use waste products to fuel the process. We can produce tons of protein in an incredibly small footprintconsistently and efficiently.

"Protein production is also the primary purpose of the process[whereas most plants harvested for protein also contain large quantities of starch, oil or other components that producers need to find a market for, both for economic and sustainability reasons].

Air Protein(which utilizes single-cell organisms called hydrogenotrophs first studied by NASA in the 1960s),is using components found in the air - notably carbon dioxide - as a low-cost feedstock.

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Microbes, the third pillar in the alternative protein industry: 'The rationale is simple: Fermentation is just more efficient' - FoodNavigator-USA.com

The Reverse-Flash spent his life trying to destroy the Flash, and his efforts have made the speedster the most despicable villain in the DC Universe.

WARNING: The following contains spoilers for The Flash #761, by Joshua Williamson, Howard Porter, Hi-Fi and Steve Wands, on sale now.

Lex Luthor, Sinestro, and the Joker are thought of as some of the best villains in comic books. An often overlooked supervillain, Eobard Thawne's Reverse-Flash has proven time and again that he's not only a formidable nemesis of the Flash but thathehas the powers to affect and alter the entire DCU. The level of cruelty and downright brutality the Reverse-Flash displays makes him one of the greatestvillains.

Reverse-Flashwas created byJohn BroomeandCarmine Infantino and first appeared in The Flash #139 in 1963.Thawne comes from the 25th Century in which all mistakes have been eradicated and technology has allowed humans to achieve perfection. Through genetic engineering, Thawne's birth was guided to control everything from his I.Q. to the color of his eyes and hair. After studying the Speed Force and becoming obsessed with Barry Allen, Thawne decides that he'll dowhatever it takes to become like Barry Allen.

Related: The Flash: Reverse-Flash's Secret Superpower Is Absolutely Devious

When Thawne's parentsgave him a little brother to help with his socialization, Thawne goesback in time toerase his baby brother from existence and then kills his parents when they try and interfere with his research. When he's jilted by a love interest who has a fiance, Thawne not onlykills the fiance but erases him from the timeline altogether. When she still won't go out with him, he goes back in time to when she was a little girl and shakes her so violentlythat she becomes brain damaged and is institutionalized. Now his younger self will never have the opportunity to meet her.

Thawne is avillain that if you wrong him, he'll kill you, your best friend, your family, and erase any trace of you from existence. During the "Flashpoint" storyline, Thawne is the only person to know that Barry Allen completely messed up the timeline. Barry went back in time to prevent Thawnefrom killing his mother, thereby creating a new timeline. Thawne helpsBarry realize what he did not because Thawne wants to see everything go back to normal. Thawne wants Barry to have to make the choice of either leaving the timeline screwed up or letting Reverse-Flash kill his mother. Thawne is able to mentally torture people on a level that is seldom seen in comic books.

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The Flash Shows Why the Reverse-Flash Is DC's Greatest Nemesis - CBR - Comic Book Resources