StemCell Therapy

LONDON--(BUSINESS WIRE)--Gyroscope Therapeutics Limited, a clinical-stage retinal gene therapy company, today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to GT005 for the treatment of geographic atrophy (GA) secondary to dry age-related macular degeneration (AMD). GT005 is an investigational one-time AAV-based gene therapy that is delivered under the retina and is intended to slow the progression of GA that can lead to blindness.

Fast Track designation was granted to GT005 for the treatment of people with GA who have specific mutations in their Complement Factor I (CFI) gene and low levels of the CFI protein in their blood. Enrolment in the Phase II EXPLORE study [NCT04437368] to evaluate GT005 in this group of people is underway.

Dry AMD is a life-altering diagnosis and there are currently no FDA-approved medicines available. Research suggests people with dry AMD who have certain CFI mutations that correlate with low CFI levels in the blood have a higher risk of developing AMD,1 said Nadia Waheed, M.D., MPH, Chief Medical Officer. We are pleased to receive Fast Track designation for our investigational gene therapy for this high-risk group. We look forward to working with the FDA as we advance our clinical programme evaluating the safety and effectiveness of GT005.

In addition to EXPLORE, Gyroscope also plans to initiate a second Phase II trial in 2020 that will evaluate GT005 in a broader group of people with GA.

The FDAs Fast Track programme streamlines the review of drugs for serious conditions without FDA-approved treatment options available. Fast Track designation gives applicants access to more frequent communication with the FDA throughout the review process, and the potential to apply for Accelerated Approval and Priority Review if relevant criteria are met, as well as Rolling Review, which means that completed sections of the Biologic License Application can be submitted for review before the entire FDA application is complete.

About Age-Related Macular Degeneration (AMD) and Geographic Atrophy (GA)

AMD is a leading cause of blindness affecting an estimated 196 million people globally.2 AMD typically affects people aged 50 and older, and causes a gradual and permanent loss of central vision that worsens over time.3 There are no approved treatments for the dry form of AMD, which is the most common, impacting approximately 90% of people with the disease.4 As dry AMD advances it leads to GA, an irreversible degeneration of retinal cells. This vision loss can be devastating, severely impacting a persons daily life as they lose the ability to drive, read, and even see the faces of loved ones.

Gyroscope estimates that nearly 3.5 million people in the United States and EU5 European countries have GA, and that more than 100,000 people with GA have certain CFI mutations that correlate with low CFI levels in the blood and a higher risk of developing AMD.5, 6, 7

About Gyroscope: Vision for Life

Gyroscope Therapeutics is a clinical-stage retinal gene therapy company developing and delivering gene therapy beyond rare disease to treat a leading cause of blindness, dry AMD. Our lead investigational gene therapy, GT005, is a one-time therapy delivered under the retina. GT005 is designed to restore balance to an overactive complement system by increasing production of the Complement Factor I protein. GT005 is currently being evaluated in a Phase I/II clinical trial called FOCUS and a Phase II clinical trial called EXPLORE.

Syncona Ltd, our lead investor, helped us create the only retinal gene therapy company to combine discovery, research, drug development, a manufacturing platform and surgical delivery capabilities. Headquartered in London with locations in Philadelphia and San Francisco, our mission is to preserve sight and fight the devastating impact of blindness. For more information visit: http://www.gyroscopetx.com and follow us on Twitter (@GyroscopeTx) and on LinkedIn.

References

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1 Kavanagh D, Yu Y, Schramm EC, et al. Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum factor I levels. Hum Mol Genet. 2015;24(13):3861-3870.2 Wong WL, Su X, Li X, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health 2014;2:e106116.3 National Eye Institute. Age-Related Macular Degeneration. https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/age-related-macular-degeneration.4 Centers for Disease Control and Prevention. Age-Related Macular Degeneration. https://www.cdc.gov/visionhealth/basics/ced/.5 Friedman DS, O'Colmain BJ, Muoz B, et al. Prevalence of age-related macular degeneration in the United States [published correction appears in Arch Ophthalmol. 2011 Sep;129(9):1188]. Arch Ophthalmol. 2004;122(4):564-572.6 Rudnicka AR, Kapetanakis VV et al. Incidence of late-stage age-related macular degeneration in American whites: systematic review and meta-analysis. Am J Ophthalmol 2015;160:85-93.7 Data on File.

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Gyroscope Therapeutics Granted FDA Fast Track Designation for GT005, an Investigational Gene Therapy for Dry Age-Related Macular Degeneration -...

BOTHELL, Wash., Sept. 21, 2020 /PRNewswire/ -- BioLife Solutions. (NASDAQ: BLFS)("BioLife" or the "Company"), a leading developer and supplier of a portfolio of class-defining bioproduction tools for cell and gene therapies, today announced it has entered into a definitive agreement to acquire SciSafe, a privately held multi-facility provider of biological materials storage to the cell and gene therapy and pharmaceutical industries. The transaction is expected to close on September 30th.

SciSafe had 2019 unaudited revenue of $6 million and positive EBITDA and is anticipated to be accretive during 2021.

Under the terms of the agreement, BioLife will pay $15 million in cash and $15 million in newly issued shares of BioLife common stock for 100% of the outstanding shares of SciSafe. SciSafe's shareholders are also eligible over the next four years to receive up to 626,000 additional shares of BioLife common stock based on the achievement of annual revenue milestones.

Mike Rice, Chief Executive Officer of BioLife Solutions, commented, "This acquisition enables BioLife to offer even more value to our cell and gene therapy customers through an established business with an excellent reputation, marquee customers and seasoned team. Through SciSafe, we are accelerating profitable growth by expanding into the high growth biostorage segment with a robust quality system, a scalable business model and strong financial performance. We anticipate several vertical integration cost synergies including using SciSafe facilities for cGMP storage of our biopreservation media products, leveraging our CBS facility to manufacture walk-in freezer rooms for SciSafe and deploying our evo Smart Shippers and evoIS cloud app for the thousands of annual inbound and outbound biologic materials shipments managed by SciSafe."

Garrie Richardson, President of SciSafe, remarked, "I'm thrilled to be joining forces with BioLife. With BioLife's stellar reputation in the cell and gene therapy market, key customer relationships, financial resources and commitment to fund our growth, the SciSafe team is poised to deliver significant high-margin incremental revenue to BioLife's growing enterprise."

Benefits of the Transaction

Entry into the fast-growing biostorage segment

Cross-selling opportunities

Potential vertical integration cost synergies

Financial Impact of SciSafe Acquisition

BioLife expects the acquisition of SciSafe to impact the Company's financial performance as follows:

About SciSafeFounded in 2010, SciSafe offers dedicated pharmaceutical and biological specimen storage in its four fully cGMP-compliant state-of-the-art sample management facilities. SciSafe has built flourishing relationships with over 300 of the world's leading and most admired organizations. Clients have repeatedly chosen to store their most valued and irreplaceable biological samples because they trust SciSafe to care for them as if they were their own. SciSafe values and respects its long-term client relationships. With over 60 years combined experience specifically in life sciences, SciSafe personnel fully appreciate the vital requirements of all areas of specimen storage and cold chain management. For more information, please visit http://www.scisafe.com.

About BioLife SolutionsBioLife Solutions is a leading supplier of a portfolio of class-defining cell and gene therapy bioproduction tools and services. Our tools portfolio includes our proprietaryCryoStorfreeze media and HypoThermosolshipping and storage media, ThawSTARfamily of automated, water-free thawing products, evocold chain management system, and Custom Biogenic Systemshigh capacity storage freezers. Services include SciSafe biologic and pharmaceutical materials storage. For more information, please visit http://www.biolifesolutions.com, and follow BioLife on Twitter.

Cautions Regarding Forward Looking Statements Except for historical information contained herein, this press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, but are not limited to, statements concerning the expected financial performance of the company following the completion of its acquisition of SciSafe, the expected synergies between the company and SciSafe, the company's ability to realize all or any of the anticipated benefits associated with the acquisition of SciSafe, the company's ability to implement its business strategy and anticipated business and operations, including following the acquisition of SciSafe, the potential utility of and market for the company's and SciSafe's products and services, guidance for financial results for 2020 and 2021, including regarding SciSafe's revenue, and potential revenue growth and market expansion, including with consideration to our acquisition of SciSafe. All statements other than statements of historical fact are statements that could be deemed forward-looking statements. These statements are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and assumptions that could cause actual results to differ materially from those described in the forward-looking statements, including among other things, uncertainty regarding unexpected costs, charges or expenses resulting from the company's acquisition of SciSafe or the 2019 acquisitions, charges or expenses resulting from the acquisition of SciSafe; market adoption of the company's products (including the company's recently acquired products) or SciSafe's products; the ability of the SciSafe acquisition to be accretive on the company's financial results; the ability of the company to implement its business strategy; uncertainty regarding third-party market projections; market volatility; competition; litigation; the impact of the COVID-19 pandemic; and those other factors described in our risk factors set forth in our filings with the Securities and Exchange Commission from time to time, including our Annual Report on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. We undertake no obligation to update the forward-looking statements contained herein or to reflect events or circumstances occurring after the date hereof, other than as may be required by applicable law.

Media & Investor RelationsRoderick de GreefChief Financial Officer(425) 686-6002rdegreef@biolifesolutions.com

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BioLife Solutions to Acquire SciSafe, a High-Growth Biostorage Service Provider to the Cell and Gene Therapy Industry - BioSpace

SOMERSET, N.J. (PRWEB) September 22, 2020

Catalent, the leading global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell and gene therapies, and consumer health products, today announced that George Buchman, Ph.D., Vice President, Preclinical & Process Development, Catalent Cell & Gene Therapy, will present at the World Vaccine Congress, which will take place virtually on Sept. 28 October 1, 2020.

On Sept. 30 at 4:05 p.m. EST, Dr. Buchman will present Next-Generation Vaccines and Oncolytic Viruses: Current Challenges and Future Promise, giving an overview of the benefits and limitations of oncolytic viruses as immunotherapies. His presentation will discuss the manufacturing and analytical considerations, as well as a collaborative study that evaluates a new technology to assess transfection efficiency.

Dr. Buchman joined Catalent through its acquisition of Paragon Gene Therapy in 2019. He has more than 30 years of experience in the biotech industry, and has held roles at companies including Life Technologies (now Thermo Fisher), Celera Genomics and Gene Logic. Dr. Buchman obtained a bachelors degree in biochemistry from Albright College, Reading, Pennsylvania, and a doctorate in biochemistry from University of Maryland.

For more information, please visit https://biologics.catalent.com/events/world-vaccine-congress/.

About Catalent Cell & Gene TherapyWith deep experience in viral vector scale-up and production, Catalent Cell & Gene Therapy is a full-service partner for adeno-associated virus (AAV) and lentiviral vectors, and CAR-T immunotherapies. When it acquired MaSTherCell, Catalent added expertise in autologous and allogeneic cell therapy development and manufacturing to position it as a premier technology, development and manufacturing partner for innovators across the entire field of advanced biotherapeutics. Catalent has a global cell and gene therapy network of dedicated, large-scale clinical and commercial manufacturing facilities, and fill-finish and packaging capabilities located in both the U.S. and Europe. An experienced partner, Catalent Cell & Gene Therapy has worked with industry leaders across 70+ clinical and commercial programs. For more information, visit biologics.catalent.com/cell-gene-therapy/

About CatalentCatalent is the leading global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell and gene therapies, and consumer health products. With over 85 years serving the industry, Catalent has proven expertise in bringing more customer products to market faster, enhancing product performance and ensuring reliable global clinical and commercial product supply. Catalent employs approximately 14,000 people, including around 2,400 scientists and technicians, at more than 45 facilities, and in fiscal year 2020 generated over $3 billion in annual revenue. Catalent is headquartered in Somerset, New Jersey. For more information, visit http://www.catalent.com

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Advantages of Oncolytic Viruses as Immunotherapies to be Discussed by Catalent Gene Therapy Expert at World Vaccine Congress - PR Web

LONDONandNEW YORK, Sept. 22, 2020 (GLOBE NEWSWIRE) -- MeiraGTx Holdings plc(Nasdaq: MGTX), a vertically integrated, clinical stage gene therapy company, today announced nine-month results from the ongoing Phase 1/2 clinical trial(NCT03252847) of AAV-RPGR, an investigational gene therapy for the treatment of X-linked retinitis pigmentosa (XLRP), will be presented in an oral session at the EURETINA 2020 Virtual Meeting taking place October 2-4, 2020.

Details of the presentation are listed below. Data is embargoed until the date and time of presentation.

Title: Phase 1/2 Clinical Trial of AAV-RPGR Gene Therapy for RPGR-Associated X-Linked Retinitis Pigmentosa: 9-month ResultsPresenter: Michel Michaelides, BSc MB BS MD(Res) FRCOphth FACSDate and Time: Saturday, October 3, 10:45am EDT (4:45pm CEST)Session: EURETINA Session 11: Late Breaking & Reviews

MeiraGTx and Janssen Pharmaceuticals, Inc. (Janssen), one of the Janssen Pharmaceutical Companies of Johnson & Johnson, are jointly developing AAV-RPGR as part of a broader collaboration to develop and commercialize gene therapies for the treatment of inherited retinal diseases.

In July 2020, MeiraGTx announced six-month data from the ongoing Phase 1/2 MGT009 clinical trial, which demonstrated AAV-RPGR was generally well tolerated and produced significant improvement in vision in the dose escalation phase of the trial.

About AAV-RPGRAAV-RPGR is an investigational gene therapy for the treatment of patients with X-Linked Retinitis Pigmentosa (XLRP) caused by mutations in the eye specific form of theRPGRgene (RPGRORF15). AAV-RPGR is designed to deliver functional copies of theRPGRgene to the subretinal space in order to improve and preserve visual function.MeiraGTxand development partner Janssen are currently conducting a Phase 1/2 clinical trial of AAV-RPGR in patients with XLRP with mutations inRPGRORF15. AAV-RPGR has been granted Fast Track and Orphan Drug designations by theU.S. Food and Drug Administration(FDA) and PRIME, ATMP and Orphan designations by theEuropean Medicines Agency (EMA).

About the Phase 1/2 MGT009 Clinical TrialMGT009 is a multi-center, open-label Phase 1/2 trial (NCT03252847) of AAV-RPGR gene therapy for the treatment of patients with XLRP associated with disease-causing variants in theRPGRgene. MGT009 consists of three phases: dose-escalation, dose-confirmation, and dose-expansion. Each patient was treated with subretinal delivery of AAV-RPGR in the eye that was more affected at baseline. The patients other eye served as an untreated control. In dose-escalation (n=10), adults were administered low, intermediate, or high dose AAV-RPGR. The primary endpoint was safety. Visual function was assessed at baseline, three, six, nine and 12 months with Octopus 900 full-field static perimetry and mesopic fundus-guided microperimetry (MP); mean retinal sensitivity, visual field modeling and analysis (VFMA; Hill-of-vision volumetric measure), and pointwise comparisons were examined.

About X-Linked Retinitis Pigmentosa (XLRP)XLRP is the most severe form of retinitis pigmentosa (RP), a group of inherited retinal diseases characterized by progressive retinal degeneration and vision loss. In XLRP, both rods and cones function poorly, leading to degeneration of the retina and total blindness. The most frequent cause of XLRP is disease-causing variants in theRPGRgene, accounting for more than 70% of cases of XLRP, and up to 20% of all cases of RP. There are currently no approved treatments for XLRP.

AboutMeiraGTxMeiraGTx(Nasdaq: MGTX) is a vertically integrated, clinical stage gene therapy company with six programs in clinical development and a broad pipeline of preclinical and research programs.MeiraGTx has core capabilities in viral vector design and optimization and gene therapy manufacturing, as well as a potentially transformative gene regulation technology. Led by an experienced management team,MeiraGTxhas taken a portfolio approach by licensing, acquiring and developing technologies that give depth across both product candidates and indications. MeiraGTxs initial focus is on three distinct areas of unmet medical need: inherited retinal diseases, neurodegenerative diseases and severe forms of xerostomia. Though initially focusing on the eye, central nervous system and salivary gland,MeiraGTxintends to expand its focus in the future to develop additional gene therapy treatments for patients suffering from a range of serious diseases.

For more information, please visitwww.meiragtx.com.

Forward Looking StatementThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including, without limitation, statements regarding the development and efficacy of AAV-RPGR, plans to advance AAV-RPGR into Phase 3 clinical trial and anticipated milestones regarding our clinical data and reporting of such data and the timing of results of data, including in light of the COVID-19 pandemic, as well as statements that include the words expect, intend, plan, believe, project, forecast, estimate, may, should, anticipate and similar statements of a future or forward-looking nature. These forward-looking statements are based on managements current expectations. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including, but not limited to, our incurrence of significant losses; any inability to achieve or maintain profitability, acquire additional capital, identify additional and develop existing product candidates, successfully execute strategic priorities, bring product candidates to market, expansion of our manufacturing facilities and processes, successfully enroll patients in and complete clinical trials, accurately predict growth assumptions, recognize benefits of any orphan drug designations, retain key personnel or attract qualified employees, or incur expected levels of operating expenses; the impact of the COVID-19 pandemic on the status, enrollment, timing and results of our clinical trials and on our business, results of operations and financial condition; failure of early data to predict eventual outcomes; failure to obtain FDA or other regulatory approval for product candidates within expected time frames or at all; the novel nature and impact of negative public opinion of gene therapy; failure to comply with ongoing regulatory obligations; contamination or shortage of raw materials or other manufacturing issues; changes in healthcare laws; risks associated with our international operations; significant competition in the pharmaceutical and biotechnology industries; dependence on third parties; risks related to intellectual property; changes in tax policy or treatment; our ability to utilize our loss and tax credit carryforwards; litigation risks; and the other important factors discussed under the caption Risk Factors in our Quarterly Report on Form 10-Q for the quarter endedMarch 31, 2020, as such factors may be updated from time to time in our other filings with theSEC, which are accessible on the SECs website atwww.sec.gov. These and other important factors could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent managements estimates as of the date of this press release. While we may elect to update such forward-looking statements at some point in the future, unless required by law, we disclaim any obligation to do so, even if subsequent events cause our views to change. Thus, one should not assume that our silence over time means that actual events are bearing out as expressed or implied in such forward-looking statements. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date of this press release.

Contacts

Investors:MeiraGTxElizabeth (Broder) Anderson (646) 860-7983elizabeth@meiragtx.com

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Media:W2O pureChristiana Pascale(212) 257-6722cpascale@purecommunications.com

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MeiraGTx Announces Data from Ongoing Clinical Trial of AAV-RPGR for the Treatment of X-Linked Retinitis Pigmentosa to be Presented at EURETINA 2020...

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Gene therapies are set to revolutionise healthcare by treating diseases at the genetic level. They address the underlying cause of disease and can restore a patient to normal or near normal health. As one-time, personalised treatments, gene therapies have the potential to transform current care pathways by offering eligible patients durable outcomes when successful.

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They offer a one-time intervention, when often the alternative is decades of chronic treatment and monitoring, benefitting both patients and carers. Health and social care systems could also benefit, when complex chronic care regimes can be eliminated or greatly reduced, with significant resources re-deployed across the health and social care system; pertinent in a post-covid-19 world. Of course, gene therapy, as well as the procedure needed to prepare patients to receive it, can have serious side effects and there must be a rigorous assessment of potential risks and benefits to identify the right patients for the treatment.

Additionally, the cost-effectiveness of gene therapies, depends very much on their capacity of delivery health and social savings over a patients lifetime. As many patients treated with gene therapies will be children and young adults, the treatment may deliver additional societal gains over decades.

There are currently over 950 companies worldwide developing Advanced Therapy Medicinal Products, with therapies being tested in 1052 clinical trials, as of Q3 2019.1 Many of these are gene therapies that may become available in the UK over the next five years.

Provision needs to be made urgently for aligned regulatory assessment, health technology appraisal and NHS managed introduction, both in terms of infrastructure as well as reallocated budget. Life science companies also have a responsibility to set value-based prices and should consider alternative payment models and risk share agreements in collaboration with the NHS and government to further ensure value and affordability.

Gene therapies are positive and disruptive technologies that require whole system change to ensure that a post-Brexit NHS is at the forefront of provision rather than lagging behind its European neighbours. There is a window of opportunity for the MHRA with renewed responsibilities in 2021, as well as the National Institute for Health and Care Excellence currently conducting its Methods Review to ensure both regulatory and appraisal systems are aligned for optimal assessment of modern medicines, including gene therapies.

NICEs review of the methods is highly significant as it will set the framework for how England and Wales will provide access to new and breakthrough medicines. Areas of focus should include wider recognition of gene therapies and their benefits, including the one-off treatment offer to patients, gains to the health and social care system, plus pragmatic ways to address inherent lifetime uncertainty.

Crucially, for paediatric and young adult patients, there is an additional challenge the NICE methods review needs to resolve. High economic discount rates used in the health economic assessment process by NICE has a prejudicial impact on the cost-effectiveness of treatments that are intended to offer benefits over decades, such as gene therapies. This issue can be easily addressed if Treasury guidance for utilising lower discount rates is adopted.

A successful NICE Methods Review would ensure that the UK has a fit-for-purpose medicines assessment process. This will help to achieve world-leading status for bringing new medicines such as gene therapy to patients and will sustain UK-based research and development investment. This should be prioritised as the end of the EU exit transition period approaches, to ensure the governments vision of a vibrant post-Brexit economy, fuelled by science and technology, allows the UK to lead the world in healthcare innovation.

1. Alliance for Regenerative Medicine. Quarterly regenerative medicine sector report Q3. 2019. Available at: https://alliancerm.org/?smd_process_download=1&download_id=5556 [Accessed 11 February 2020].

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Gene Therapy will the NHS lead or follow? - Health Service Journal

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When James Landon received a mantle cell lymphoma (MCL) diagnosis in 2017, he was told his disease was indolent, meaning it was slow growing and didnt need to be treated right away, especially since he was feeling fine.

But that changed in 2019. Landon, 50, an attorney in Tucson, Arizona, started to feel tired all the time. His physicians discovered that his white blood cell count was sky-high and his spleen was enlarged.

The first-line treatment for MCL has long been high doses of chemotherapy, often followed by a stem cell transplant. But when Landon traveled to The University of Texas MD Anderson CancerCenter in Houston to explore his options, he was offered an alternative: an experimental regimen combining the drugs Imbruvica (ibrutinib) and Rituxan (rituximab). Imbruvica blocks a protein called Bruton tyrosine kinase (BTK), which is a driver of MCL, and Rituxan is an antibody that targets overactive B cells of the immune system that have been implicated in the disease.

Five months after starting the combination four Imbruvica pills every morning and once-weekly infusions of Rituxan Landons positron emission tomography (PET) scan showed no evidence of disease. If he stays clear, hell undergo a short course of chemotherapy and then move to a maintenance therapy of one year of Ibrutinib and two of Rituxan.

Having this option has been fantastic, in my opinion, because the drugs so far have worked well for me, with no toxicity, says Landon, who adds that he has plenty of energy to work full time and play with his 10-year-old son.

BTK inhibitors and immunotherapy are among the newer therapeutic options for patients with MCL that are greatly improving the outlook for long-term survival. In addition to these targeted drugs, Tecartus (brexucabtagene autoleucel) the first cell-based gene therapy for MCL in patients who havent responded to or who have relapsed following other kinds of treatment was approved by the Food and Drug Administration (FDA) in July and is a one-time personalized treatment made from patients own immune cells.

We now have several good nonchemotherapy options for treating MCL, says Dr. Anthony Nguyen, a professor at the University of Nevada, Las Vegas School of Medicine and a medical oncologist at Comprehensive Cancer Centers of Nevada. We may be able to tell patients we can treat them without toxic chemotherapy, which can be reassuring, particularly for older patients.

MCL is a subtype of non-Hodgkin lymphoma (NHL) thats characterized by the overproduction of a protein called cyclin D1. In about 85% of patients, that overproduction is caused by a genetic abnormality called reciprocal chromosomal translocation, which can be detected with diagnostic testing of tumor samples. MCL accounts for about 6% of all NHL diagnoses and is more common in men than in women, according to the Leukemia & Lymphoma Society.

The standard first-line treatment for MCL is high-dose chemotherapy, often with a four-medicine regimen called hyper-CVAD, followed by a stem cell transplant with a patients own cells or with those from a donor. The regimen often puts patients into long-term remissions, but the side effects including nausea, mouth ulcers and kidney damage can be difficult or even dangerous, particularly for patients with other illnesses.

The newer medicines and cell therapy were approved by the FDA to treat patients with MCL who dont respond to chemotherapy and transplants or who relapse. But as physicians gain more experience with these therapies, theres a growing interest in using them earlier in the treatment process to not only improve the chances of long-term remissions, but also to improve the quality of life for patients by sparing them from harsh side effects.

The FDA approved the first BTK inhibitor to treat MCL, Imbruvica, in 2013, based on a study showing an overall response rate (meaning the disease responded to treatment) of 68% and a complete response rate (the disappearance of all signs of cancer) of 21%. The average period that patients lived without their disease progressing was more than a year, and side effects were mild stomach upset and fatigue.

The more recently approved BTK inhibitors Calquence (acalabrutinib) and Brukinsa (zanubrutinib) have improved on those response rates. Patients receiving Brukinsa in a late-stage trial, for example, had an overall response rate of 89% and a complete response rate of 59%.

Another targeted treatment, Venclexta (venetoclax) is also being studied in MCL. Venclexta targets the protein BCL2, which promotes cell survival and is abnormally elevated in MCL helping to drive progression of the disease. In a small trial of Venclexta, 75% of patients with relapsed MCL responded to the drug, 21% of whom had complete responses. Theres even more interest in studying BCL2 inhibition in combination with BTK blockers. In a recent study of Venclexta combined with Imbruvica, the median progression-free survival time was 29 months.

This is an extremely promising combination, says Dr. Abhijeet Kumar, assistant professor in the division of hematology and oncology at the University of Arizona College of Medicine. Kumar is an investigator in an ongoing trial of Venclexta and Imbruvica in MCL.

There is, however, a risk of increased side effects when targeted treatments are combined. Imbruvica can cause bleeding, for example, and both drugs can lower neutrophil (a type of white blood cell) counts. Venclexta is also known to cause tumor lysis syndrome, a rapid release of tumor cells into the bloodstream that can endanger the kidneys and other organs. Still, so far, the combination seems to be well-tolerated, Kumar says.

Another two-drug treatment for MCL that has generated enthusiasm among oncologists treating the disease is dubbed R-squared because it combines Rituxan with Revlimid (lenalidomide), a drug that works by boosting the immune systems T cells and natural killer cells, which work together to attack cancer.

In a study of R-squared in 38 patients with newly diagnosed MCL, the progression-free survival rate after three years was 80% and overall survival reached 90%. The response is durable, says Dr. Bijal Shah, an associate member in the department of malignant hematology at Moffitt Cancer Center and one of the study investigators. During the R-squared trial, patients typically stayed on the combination for three years and then took Revlimid alone as long as the disease remained stable.

Similar benefits have been seen with a combination of Velcade (bortezomib), Revlimid and chemotherapy, a regimen called VR-CAP. Velcade is a targeted drug that works by disrupting the growth of MCL cells and prompting them to die.

In a trial of patients with untreated MCL, adding Velcade to Revlimid and chemotherapy extended progression-free survival by 37%. The addition of Velcade more than doubled the median duration of response to 41 months.

Both R-squared and VR-CAP have moved into the frontline treatment setting, Shah says. With that, were able to see really pronounced clinical benefits. Weve seen very long remissions, he says.

Several other combination strategies also are being investigated for MCL, including some that incorporate the drug Treanda (bendamustine), which works by causing DNA damage to cancer cells. In one study, combining Treanda with Rituxan improved progression-free survival rates over chemotherapy in patients with MCL or indolent NHL. More than 15 studies are now underway combining Treanda with Rituxan and other MCL treatments.

Even though targeted and combination treatments have extended survival times in MCL, most patients eventually relapse. Now theres a new option for those patients: Tecartus, a personalized therapy made from a patients own immune cells. The one-time treatment was approved by the FDA to treat patients who have not responded or have relapsed following other kinds of treatment.

Tecartus is a chimeric antigen receptor (CAR)-T cell therapy similar to Yescarta (axicabtagene ciloleucel), a CAR-T cell therapy approved by the FDA in 2017 to treat some types of large B-cell lymphomas. Like Yescarta, Tecartus targets CD19, a protein thats prevalent in cancerous B cells. Tecartus is made by extracting T cells from the blood of the patient with MCL and genetically modifying those cells to recognize and attack the cancer. In addition, the cells are put through an enrichment process designed to prevent them from wearing down before they are infused back into the patient.

In the clinical trial that led up to the approval, 87% of patients responded to Tecartus and 62% went into remission. Side effects, which included the immune overreaction known as cytokine release syndrome and neurological events, were manageable during the clinical trial, says Dr. Michael Wang, a professor in the department of lymphoma and myeloma at The University of Texas MD Anderson Cancer Center and one of the clinical trial investigators.

Experience with previously approved CAR-T cell treatments led to the widespread use of anti-inflammatory medications such as interleuken-6 inhibitors and steroids to treat cytokine release syndrome, Wang says. We have a variety of supportive measures to manage the side effects, he says.

With the approval of Tecartus, Wang says oncologists can envision a flattening of the survival curve in MCL. Its an option for people who become resistant to targeted therapies and chemotherapy, he says. Its very possible we will be able to put some people into long- term remissions.

Bob Brixner, a 20-year survivor of MCL, has been watching all the new developments with interest. When he received an MCL diagnosis in 2000, he had no choice but to endure chemotherapy followed by a stem cell transplant with his own cells. When he relapsed in 2004, he was prescribed a more intense chemotherapy regimen, followed by a stem cell transplant from an unrelated donor.

Hes grateful the second treatment put him in a long-term remission, but he still remembers the brutal side effects, which included extreme fatigue and a bout with pneumonia. And with the transplants, my immune system didnt come back 100%, says Brixner, 70, a retired Chicago public schoolteacher. Nowadays if I catch a cold, instead of lasting a week, it will last three.

Brixner advises all newly diagnosed patients to ask a lot of questions about their treatment choices and to get a second opinion. I think its really important to be an informed patient, he says, especially since there are so many new choices. Some patients may not have to go through what I did, he says. Im delighted.

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Advances in the Treatment of Mantle Cell Lymphoma are Greatly Improving the Long-Term Outlook for Patients - Curetoday.com

Axovant Gene Therapies Ltd. (NASDAQ:AXGT) has announced the signing of a strategic partnership with leading Contract Development and Manufacturing Organisation, Viralgen.

Viralgen, which is leveraging AskBios tech platforms, has supported Axovants all manufacturing aspects of the AAV program, including large scale manufacturing, quality control, and fill-finish GMP-certified environment that has been tailored to bring therapies to the market quickly. As per the terms of the agreement, Axovant will get access to manufacturing resources of its AAV-based gene therapy programs with adequate capacity to support the development and eventual commercialization of the therapies. Axovant has is developing the AXO-AAV-GM1 for GM gangliosidosis and AXO-AAV-GM2 for GM2 gangliosidosis.

Gavin Corcoran, the Chief R & D Officer of the company, stated that they are pleased to collaborate with Viralgen, a leading manufacturer of AAV-based gene therapies. He said that the partnership will enable Axovant to produce their novel gene therapies that can improve or stabilize the course of GM1 and GM2 gangliosidoses on a commercial scale. The GM1 and GM2 gangliosidosis are two problematic pediatric diseases that do not have any approved treatment alternatives.

Corcoran said that the partnership with Viralgen offers the company access to a huge facility and experienced team that is focused on delivering tech that will speed up the development of life-saving therapies. He explained that the approach is important as the company continues to advance the AAV programs with data from the current Phase1/2 AXO-AAV-GM1 study expected in Q4 2020. The company is also expecting to file an IND clearance for AXO-AAV-GM2 before the end of this year.

Viralgen CEO Javier Garcia stated that they were delighted to partner with Axovant, and they are looking forward to offering priority access and support to advance AAV gene therapies for the devastating podiatric diseases. He added that the companys scalable and flexible production platform will be vital in complementing the development efforts of Axovant through commercialization from clinical trials.

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Axovant Gene Therapies Ltd. (NASDAQ:AXGT) Partners With Viralgen To Scale Production Of Its AAV Gene Therapies - BP Journal

Garner Insights has added a new report titled, Global Gene Therapy Market Professional Report 2026 to its vast repository of research reports. This is a thorough report focused on the current and future prospects of the Global Gene Therapy Market. The report offers data of previous years along with an in-depth analysis from 2020 to 2026 on the basis of revenue (USD Billion). Besides, the report offers a comprehensive analysis about the factors driving and restraining the growth of the market coupled with the impact they have on the demand over the forecast period.

The market is segmented into different sections such as: by product type, by technology type, by application, by end-users, by deployment mode, and by key geography. The report then employs market breakdown and data triangulation procedures to complete the overall market engineering process and arrive at the exact statistics for all segments and sub-segments. The report on the Global Gene Therapy Markethas been curated by analyzing the top players functioning in the market. In order to get an in-depth analysis of the market, the report carried out SWOT analysis, Porters five forces analysis, and Pestel analysis.

Request Sample Report of Global Gene Therapy Market @ (https://garnerinsights.com/Gene-Therapy-Market-Research-Global-StatusForecast-by-Geography-TypeApplication-2016-2026#request-sample)

The report is segmented as follows:

Top Key Players: Sangamo, Spark Therapeutics, Dimension Therapeutics, Avalanche Bio, Celladon, Vical, Advantagene

By Product Type:Ex vivo, In vivo

By Application:Cancer Diseases, Monogenic Diseases, Infectious Diseases, Cardiovascular Diseases, Others

By Regions:

This report forecasts revenue growth at the global, regional, and local levels and provides an analysis of the most recent industry trends from 2020 to 2026 in each of the segments and sub-segments.In addition, the report highlights the impact of COVID-19 on the Global Gene Therapy Market. Some of the major geographies included in the market are given below:

North America (U.S., Canada)Europe (U.K., Germany, France, Italy)Asia Pacific (China, India, Japan, Singapore, Malaysia)Latin America (Brazil, Mexico)Middle East & Africa

Request for Discount on report @ (https://garnerinsights.com/Gene-Therapy-Market-Research-Global-StatusForecast-by-Geography-TypeApplication-2016-2026#discount)

Key Questions Answered in the Report:

What is the current scenario of the Global Gene Therapy Market? How is the market going to prosper throughout the next 6 years?What are the emerging technologies that are going to profit the market?What is the historical and the current size of the Global Gene Therapy Market?Which segments are the fastest growing and the largest in the market? What is their market potential?What are the driving factors contributing to the market growth during the short, medium, and long term?What are the lucrative opportunities for the key players in the market?Which are the key geographies from the investment perspective?What are the major strategies adopted by the leading players to expand their market shares?Who are the distributors, traders and dealers of Global Gene Therapy market?What are sales, revenue, and price analysis by types and applications of market?

Full Description @ (https://garnerinsights.com/Gene-Therapy-Market-Research-Global-StatusForecast-by-Geography-TypeApplication-2016-2026#description)

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Impact of Covid-19 on Gene Therapy Market Trends by Countries, Type and Application | Sangamo, Spark Therapeutics, Dimension Therapeutics, Avalanche...

Management to Highlight Progress in Bone Marrow Transplant (BMT) and Chimeric Antigen Receptor T Cell (CAR T) Business Collaborations

Tel Aviv, Israel, Sept. 21, 2020 (GLOBE NEWSWIRE) -- Cellect Biotechnology Ltd. (NASDAQ: APOP”), a developer of innovative technology which enables the functional selection of cells facilitating safer and more efficacious cell and gene therapies, today announced that the leadership will be presenting at the Cell & Gene Meeting on the Mesa, which is being held from October 12th 16th. In addition to providing an overview of the Company, the management team will provide a progress update on the clinical and development programs and an overview of the Company’s business strategy. Management will be virtually meeting cell and gene therapy companies to support collaborations.

This is one of the most prestigious meetings for our industry, and despite it being virtual this year due to the COVID-19 pandemic, it will not dampen our enthusiasm” commented Dr. Yarkoni. We have successfully adjusted our operations, and we continue to make significant progress with our Israel and U.S.-based clinical trials. We are also taking meaningful steps to accelerate nearer-term revenue opportunities as we are collaborating with several partners that are looking to leverage our technology platform to help improve their products, especially in high-growth areas such as CAR T, NK (natural killers) and MSC’s. We are looking forward to sharing the progress we have made and also look forward to meeting with current and potential partners developing cell and gene therapies.”

To schedule a meeting with the Company’s Chief Executive Officer, Dr. Shai Yarkoni or Chief Operating Officer, Amos Ofer, please request a meeting through the meeting portal and/or contact the Company direct at shai@cellect.co or amoso@cellect.co. The presentation will be available on the Company’s website prior to the commencement of the meeting. The Cell & Gene Meeting on the Mesa is the sector’s foremost annual conference bringing together senior executives and top decision-makers in the industry to advance cutting-edge research into cures.

About Cellect Biotechnology Ltd.

Cellect Biotechnology (APOP) has developed a breakthrough technology, for the functional selection of cells that aims to improve the robustness, safety and efficacy of a variety of cell and gene therapies. The Company’s technology can be used by researchers, clinical community and pharma companies in a wide variety of applications including next generation Car T, NK, MSC and gene therapies.

The Company is also developing its own product that is an improved BMT which is in a current clinical trial for cancer treatment.

Forward Looking Statements

This press release contains forward-looking statements about the Company’s expectations, beliefs and intentions. Forward-looking statements can be identified by the use of forward-looking words such as believe”, expect”, intend”, plan”, may”, should”, could”, might”, seek”, target”, will”, project”, forecast”, continue” or anticipate” or their negatives or variations of these words or other comparable words or by the fact that these statements do not relate strictly to historical matters. For example, forward-looking statements are used in this press release when we discuss Cellect’s expectations regarding timing of the commencement of its planned U.S. clinical trial and its plan to reduce operating costs. These forward-looking statements and their implications are based on the current expectations of the management of the Company only and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. In addition, historical results or conclusions from scientific research and clinical studies do not guarantee that future results would suggest similar conclusions or that historical results referred to herein would be interpreted similarly in light of additional research or otherwise. The following factors, among others, could cause actual results to differ materially from those described in the forward-looking statements: the Company’s history of losses and needs for additional capital to fund its operations and its inability to obtain additional capital on acceptable terms, or at all; the Company’s ability to continue as a going concern; uncertainties of cash flows and inability to meet working capital needs; the Company’s ability to obtain regulatory approvals; the Company’s ability to obtain favorable pre-clinical and clinical trial results; the Company’s technology may not be validated and its methods may not be accepted by the scientific community; difficulties enrolling patients in the Company’s clinical trials; the ability to timely source adequate supply of FasL; risks resulting from unforeseen side effects; the Company’s ability to establish and maintain strategic partnerships and other corporate collaborations; the scope of protection the Company is able to establish and maintain for intellectual property rights and its ability to operate its business without infringing the intellectual property rights of others; competitive companies, technologies and the Company’s industry; unforeseen scientific difficulties may develop with the Company’s technology; the Company’s ability to retain or attract key employees whose knowledge is essential to the development of its products; and the Company’s ability to pursue any strategic transaction or that any transaction, if pursued, will be completed. Any forward-looking statement in this press release speaks only as of the date of this press release. The Company undertakes no obligation to publicly update or review any forward-looking statement, whether as a result of new information, future developments or otherwise, except as may be required by any applicable securities laws. More detailed information about the risks and uncertainties affecting the Company is contained under the heading Risk Factors” in Cellect Biotechnology Ltd.’s Annual Report on Form 20-F for the fiscal year ended December 31, 2019 filed with the U.S. Securities and Exchange Commission, or SEC, which is available on the SEC’s website, http://www.sec.gov, and in the Company’s periodic filings with the SEC.

Contact Cellect Biotechnology Ltd. Eyal Leibovitz, Chief Financial Officer http://www.cellect.co +972-9-974-1444

Or

EVC Group LLC Michael Polyviou (732) 933-2754 mpolyviou@evcgroup.com

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Cellect Biotechnology to Present at the 2020 Cell & Gene Meeting on the Mesa - Stockhouse

BOSTON, Sept. 22, 2020 (GLOBE NEWSWIRE) -- Ziopharm Oncology, Inc. (Ziopharm or the Company) (Nasdaq:ZIOP), today announced the appointment of J. Kevin Buchi to the Companys Board of Directors and as Chair of the Boards Audit Committee. Additionally, Ziopharm announced that, in response to the results from the Companys recent annual meeting of stockholders, Doug Pagn has resigned from the Board.

Mr. Buchi has deep life sciences industry experience, notably 15 years with Cephalon, including serving as its Chief Executive Officer during Cephalons acquisition by Teva Pharmaceuticals in 2011 for $6.8 billion. Subsequently, Mr. Buchi served as Chief Executive Officer of TertraLogic Pharmaceuticals, and more recently as Chief Executive Officer of Biospecifics Technologies, prior to his retirement.

We are delighted to welcome Kevin to our Board of Directors, said Scott Tarriff, Chairman of the Ziopharm Board of Directors. Kevin is an accomplished executive and director, whose extensive industry experience and business and financial acumen will complement the Board. We also wish to thank Doug for his many contributions since joining the Ziopharm Board in 2018, a critical time in the Companys history, while we exited a corporate partnership and established the foundation for our core programs today. Over the past year, we have added four strong directors to our Board, including James Huang in July and Dr. Chris Bowden and Heidi Hagen last year. Looking ahead, we expect our Board will continue to evolve to reflect the needs of our business as we evolve into a commercial-stage company.

Mr. Buchi added, This is an exciting time for Ziopharm, as the Company has established a broad portfolio of innovative clinical programs to treat solid tumors and a talented team to drive company-sponsored trials in all three core programs. I am delighted to begin collaborating with Laurence and his team, as well as the other members of Ziopharms Board of Directors.

Following the acquisition of Cephalon by Teva in 2011, Mr. Buchi served as corporate vice president of global branded products at Teva. Subsequently, he was CEO TetraLogic Pharmaceuticals and Biospecifics Technologies. In addition, Mr. Buchi currently serves as chairman of Dicerna Pharmaceuticals, and as a director of Amneal Pharmaceuticals and Benitec Biopharma Ltd. Mr. Buchi earned a B.A. in Chemistry from Cornell University and a Masters in Management, Accounting and Finance from the Kellogg School of Management at Northwestern University.

The Companys Board consists of eight directors, including seven non-executive directors. The Board will continue to actively review the Board membership to ensure the skills and experience of directors support the progress and future prospects of the business.

About Ziopharm Oncology, Inc.Ziopharm is developing non-viral and cytokine-driven cell and gene therapies that weaponize the bodys immune system to treat the millions of people globally diagnosed with a solid tumor each year. With its multiplatform approach, Ziopharm is at the forefront of immuno-oncology with a goal to treat any type of solid tumor. Ziopharms pipeline is built for commercially scalable, cost effective T-cell receptor T-cell therapies based on its non-viral Sleeping Beauty gene transfer platform, a precisely controlled IL-12 gene therapy, and rapidly manufactured Sleeping Beauty-enabled CD19-specific CAR-T program. The Company has clinical and strategic collaborations with the National Cancer Institute, The University of Texas MD Anderson Cancer Center and Regeneron Pharmaceuticals. For more information, please visit http://www.ziopharm.com.

Forward-Looking Statements DisclaimerThis press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts, and in some cases can be identified by terms such as "may," "will," "could," "expects," "plans," "anticipates," and "believes." These statements include, but are not limited to, statements regarding the growth of Ziopharm from a development-stage entity to a commercial-stage company, development of its clinical portfolio and research and development programs. Although Ziopharms management team believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of Ziopharm, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include among other things, changes in our operating plans that may impact our cash expenditures, the uncertainties inherent in research and development, future clinical data and analysis, including whether any of Ziopharms product candidates will advance further in the preclinical research or clinical trial process, including receiving clearance from the U.S. Food and Drug Administration or equivalent foreign regulatory agencies to conduct clinical trials and whether and when, if at all, they will receive final approval from the U.S. FDA or equivalent foreign regulatory agencies and for which indication; the strength and enforceability of Ziopharms intellectual property rights; competition from other pharmaceutical and biotechnology companies as well as risk factors discussed or identified in the public filings with the Securities and Exchange Commission made by Ziopharm, including those risks and uncertainties listed in Ziopharms Quarterly Report on Form 10-Q filed by Ziopharm with the Securities and Exchange Commission. We are providing this information as of the date of this press release, and Ziopharm does not undertake any obligation to update or revise the information contained in this press release whether as a result of new information, future events or any other reason.

Investor Relations Contacts:Ziopharm Oncology: Chris Taylor VP, Investor Relations and Corporate CommunicationsT: 617.502.1881E: ctaylor@ziopharm.com

LifeSci Advisors:Mike MoyerManaging DirectorT: 617.308.4306E: mmoyer@lifesciadvisors.com

Media Relations Contact:LifeSci Communications:Patrick BurseyT: 646.876.4932E: pbursey@lifescicomms.com

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Ziopharm Oncology Appoints Kevin Buchi to its Board of Directors - BioSpace

Indian Biotechnology Market Size, Share & Trends Analysis Report by Type (Healthcare, Crop Production and Agriculture, Industrial, Natural Resources & Environment, and Others) and Forecast 2020-2026

Indian biotechnology market is estimated to grow significantly at a CAGR of 8.1% during the forecast period. The increasing healthcare expenditure and increasing funding in cell-based research in the country are further supporting the biotechnology market in the country. The Government of India has taken some steps to promote cell harvesting techniques in the country and have set up numbers of stem cell banks throughout the country.

Report: http://www.omrglobal.com/requestogy-market

According to International Brand Equity Foundation (IBEF), the Indian healthcare market can increase three-fold to nearly $133.4 billion in 2022. The country is experiencing growth of around 22-25% in medical tourism. Various hospital chains such as Apollo Hospitals and Global Healthcare Enterprise are growing significantly in India due to a huge prevalence of cancer and related diseases. Private hospitals are expanding their business to provide a wide range of diagnostic tests and applications to a massive pool of cancer patients including foreign patients during medical tourism.

Browse for Full Report Description atwww.omrglobal.com/industrogy-market

The Indian biotechnology market is classified on the basis of type.

Based on type, the market is segmented into healthcare, crop production and agriculture, industrial, natural resources & environment, and others. The companies which are contributing to the growth of the Indian biotechnology market include Amgen Inc., Novo Nordisk A/S, CSL Ltd., Bristol-Myers Squibb Co., AstraZeneca PLC, Merck & Co., Inc., Johnson & Johnson Services Inc., and Pfizer Inc. The market players are considerably contributing to the market growth by the adoption of various strategies including new product launch, merger, and acquisition, collaborations with government, funding to the start-ups, and technological advancements to stay competitive in the market.

Market Segmentation

Indian Biotechnology Market by Type

Company Profiles

Report: http://www.omrglobal.com/report-ogy-market

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Indian Biotechnology Market Market scrutinized in the new analysis - WhaTech

There is a lot of talk about how cell and gene therapy are going to change medicine, so why have only a few of them reached the market?

Over the last decade, only 14 advanced therapy medicinal products (ATMPs) that is, cell and gene therapies have received approval in Europe. With four withdrawals, only 10 of them still have a valid marketing authorization.

That is a stark contrast with the fact that there have been over 500 clinical trials using ATMPs in the EU since 2009. But the reality is that its a bit too soon to be expecting results many of these technologies are brand new and decades-old discoveries are only just reaching the market. For example, the development of Strimvelis, approved in 2016, took more than 20 years. The approval of Chondrocelect in 2009 took nine years since its developer, TiGenix, was founded.

Holoclar initially seemed like an exceptional case: research and development started around 1996 and the first clinical results were published just a year later. But one of its developers, Graziella Pellegrini, reported the product was under development for a total of 25 years. So those excited about CRISPR therapies, based on a gene-editing technology that was only developed in 2012, will still have to wait.

If the time scale wasnt daunting enough, research and development also burns cash quickly.A big chunk of the total money invested goes into meeting the quality, safety, and efficacy standards set by the regulatory authorities. This step seems to represent one of the biggest challenges for developers.

In fact, when regulations for ATMPs were first released in Europe, it appeared that authorities and researchers were on different wavelengths. In 2007, new European Union (EU) regulations on advanced therapies came in, which added more, very frustrating years to the development, said Pellegrini. It seemed that we had to start from scratch.

Thanks to frequent stakeholder consultations, these requirements are constantly being simplified, following the EMAs goal of fostering development and expanding patient access. But even with dynamic regulations, some products may only be authorized at thenational level and not for the whole continent.

For example, there is a dedicated pathway to exceptionally approve and commercialize ATMPs only locally as hospital exemptions. This status includes several limitations: this designation is only for non-routine products and those custom-made for individual patients, and importing or exporting them is illegal which can lead to the dangerous practice of stem cell tourism.

It seems complicated enough to reach the market with a cell or gene therapy, but the struggle isnt over at that point. The EMA can still withdraw a marketing application due to safety issues or if the company doesnt apply (and pay) for a renewal of the marketing authorization after five years.

That was the case of Glybera, the first gene therapy to receive approval in Europe. Its developers decided to not renew its market authorization after the therapys commercial failure in Europe and difficulties reaching the US market. With a very small target market and a price of one million euros, it was the most expensive treatment back in 2012, making it hard to convince governments and private insurance companies to pay for it.

In fact, only one person was treated with Glybera after its approval. Elisabeth Steinhagen-Thiessen, the doctor who prescribed it, had a lengthy fight with the German authorities and the insurance company to make them pay for the treatment. After the withdrawal, three doses left were given to patients for one euro each.

A big challenge for cell and gene therapies is that they often target conditions that affect a very small number of patients. Pharmaceutical companies are not much interested in unprofitable rare disease, commented Pellegrini.

In the case of Strimvelis, there are only about 14 people per year in Europe and 12 in the US diagnosed with its target disease, a rare form of genetic immune deficiency called ADA-SCID. The numbers are better for Holoclar, with around 1,000 people annually in Europe being eligible burn victims who have become blind but whose eyes have not been too extensively destroyed. Still,it is far short of a blockbuster.

There are exceptions, such as Imlygic, a therapy from Amgen approved in 2015 for the treatment of late-stage melanoma, with over 56,000 new cases across the EU each year.

Its fair to say that the majority of withdrawals have been made for business reasons, not safety issues. This highlights the fact that receiving EMA approval does not guarantee commercial viability the product can still be an economic failure.

Clearly, we have a lot of lessons to learn from past failure and success stories. As regulators and insurance companies become more familiar with cell and gene therapies, and developers avoid the mistakes made by others in the past, we can expect a future where cell and gene therapies become commonplace and no longer a futuristic hope.

Cover illustration by Elena Resko, images via Pharma Boardroom and the author. This article was published in April 2018 and has since been updated to reflect the latest EMA approvals.

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Why Are There Only 10 Cell and Gene Therapies in... - Labiotech.eu

The World Organisation for Animal Health (OIE) is examining how misunderstandings surrounding COVID-19 may have compromised animal welfare during the pandemic.

The COVID-19 thematic platform on animal welfare is an initiative of the OIE Collaborating Centre Network for Veterinary Emergencies, or EmVetNet, that tracks how the disease is impacting the welfare of livestock, pets, wildlife, and other animals for the purpose of identifying trends, aiding research, and informing policy.

Since the beginning of the COVID-19 pandemic, efforts are ongoing to understand the potential origin of this virus and whether animals can be infected or spread the disease. At this time, there is no sufficient evidence to suggest that any animal, including pets or livestock, play a role in the transmission of COVID-19. However, misunderstanding has resulted in threats to animal welfare, according to the EmVetNet website.

For instance, measures taken to contain the virus have disrupted many animal-related activities around the world, at places from shelters to zoos to institutes that use laboratory animals. The pandemic will also have a lasting economic impact, which in turn may impact animal ownership and animal care.

The OIE platform draws heavily on the work of Lincoln Memorial University College of Veterinary Medicine along with input from the AVMA, the Federation of Veterinarians of Europe, the International Coalition for Animal Welfare, the Israeli State Veterinary Services, and the Royal Society for the Prevention of Cruelty to Animals in the United Kingdom. Together, these organizations have set up the platform to map the impact of COVID-19 on animal welfare, observe trends, identify lessons, and share solutions and best practices to aid research, assist with policy development, and improve the response to future events, according to the EmVetNet website.

Under the direction of Dr. Gary Vroegindewey, director of the One Health Program at LMUs veterinary college, summer research students and volunteerswith faculty supervisioncollected, analyzed, and provided narratives on a wide range of COVID-19related issues across multiple animal groups. In all, they catalogued over 1,100 animal welfare-related reports and provided 48 report analyses and narratives for the OIE working group.

It is not often a student can say they conducted research for the World Organisation for Animal Health in the midst of a global pandemic that could have a lasting impact on their field of study, said Dr. Stacy Anderson, dean of LMUs veterinary college, in an Aug. 14 report on television station WVLT.

The work of Lincoln Memorial University contributes greatly to our understanding of the impacts of animal welfare during emergencies, said Dr. Paolo Dalla Villa, who chairs the Steering Group of the OIE Collaborating Centre for Animal Welfare in Europe, in the same report. The results of their contributions and the working group will go beyond the current pandemic and provide a framework to integrate animal welfare into future initiatives.

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OIE tracks COVID-19 threats to animal welfare - American Veterinary Medical Association

How should a veterinarian respond when a client asks about treating a pet dog with a cannabinoid tincture advertised as an analgesic? Is there research supporting that use or underlying any of the claims made for the scores of cannabis and cannabinoid-based products marketed for pets? Does a practitioner who recommends such a product for a patient risk running afoul of the state licensing board, the Food and Drug Administration, or the Drug Enforcement Administration?

These were just some of the thorny issues covered during the first-ever AVMA Cannabis Symposium, held Aug. 20-22 during the AVMA Virtual Convention 2020. Speakers addressed various aspects of cannabis as a veterinary therapeutic, such as regulatory and toxicological concerns, as well as its potential as an analgesic or treatment for osteoarthritis in animal patients. Following are some of the speaker highlights.

Thirty-three states have legalized marijuana for medicinal or recreational use by peopleor both. And yet, none of these laws account for use of cannabis in veterinary medicine. California is the only state to specifically address veterinarians ability to engage with clients, indicating that veterinarians can discuss the use of cannabis for medical purposes with clients without being disciplined by the veterinary medical board solely for having that conversation. By that same statute, veterinarians are prohibited from prescribing, dispensing, or administering any cannabis or cannabis-based products. The statute does not address the therapeutic use of products derived from industrial hemp, which are covered under provisions of the states veterinary practice act applicable to diagnosing, prescribing, or administering a drug for prevention or treatment of an animals condition.

The Food and Drug Administration has approved only one cannabis-derived drug and three synthetic cannabis-related drugs, all for use in human medicine. No other cannabis, cannabis-derived, or cannabidiol product currently available is approved by the agency.

We certainly recognize the potential opportunities that cannabis-derived compounds may offer and acknowledge the significant interest in these possibilities, said symposium speaker Randall Gnatt, a senior regulatory counsel in the Office of Surveillance and Compliance in the FDAs Center for Veterinary Medicine.

Were also aware that some companies are marketing products in ways that violate the federal Food, Drug, and Cosmetic Act and then may put the health and safety of people and animals at risk, he explained. The agency is committed to protecting the public health while also taking steps to improve the efficiency of regulatory pathways for the lawful marketing of appropriate cannabis-derived products.

Gnatt said the FDA is conducting a comprehensive evaluation of CBD and related products with a focus on educating the public about these products, informing the agencys regulatory considerations of these products, and taking action when necessary to protect public health.

We understand theres high demand with consumers seeking out these novel products for a variety of perceived health-related or other reasons. But as the agency has stated before, we are concerned that some people wrongly think that the myriad of CBD products on the market have been evaluated by FDA and determined to be safe, which, as Gnatt explained, isnt the case.

Other than the approved human prescription drug, we know little about the potential effects of sustained or cumulative long-term use of CBD, Gnatt continued. We dont know about coadministration with other medicines or risks to vulnerable human and animal populations. This doesnt mean that we know CBD is categorically unsafe under all circumstances, but given the gaps in our current knowledge and the known risks that have been identified, were not at a point where we can conclude that CBD products are safe for use.

Little is known about the effects of cannabis and CBD on various nonhuman animal species, particularly with regard to the accumulation of residues in the edible tissues of food-producing animals. There is a great need for more rigorous scientific research into both safety and potential therapeutic uses of cannabis-derived products for animals, Gnatt said.

Conflicting federal and state laws either prohibiting or sanctioning medical marijuana or hemp-derived CBD can put veterinarians in a difficult spot. Clients are able to get these products right down the street or through the internet, and theyre looking for advice from their veterinarian, said Jim Penrod, executive director of the American Association of Veterinary State Boards.

Penrod spoke during the cannabis symposium about the varying views among U.S. veterinary licensing boards about the issue. Marijuana was illegal for decades, he explained, adding that the drug was difficult to study given its classification as a Schedule 1 substance. When California legalized medical marijuana in 2006, the state let the genie out of the bottle, as it were, with the decriminalization process quickly outpacing the research.

Because things are progressing so quickly and decisions are being made so quickly Im not going to give you the answers today. Im not going to tell you that, Yes, its fine for you to go talk about cannabis, or Its fine for you to dispense. I dont have those answers, Penrod said.

In 2019, the AAVSB surveyed state veterinary licensing boards about whether it is legal for a veterinarian to discuss cannabis with a client. Penrod said the association recently contacted those boards to determine whether they were still comfortable with the answers they gave in the 2019 survey, and several changed their answers.

Responses varied from one extreme to the other. Six states said veterinarians could lose their license if they even talk about cannabis, four said veterinarians need to adhere to federal law, seven said state boards cant even provide legal advice, seven said they have no formal opinion on the matter, two said veterinarians could talk about cannabis but only if the client starts the conversation, 18 responded that veterinarians could discuss cannabis but could not prescribe or dispense it, and four said veterinarians could discuss the topic.

The position of the AAVSB is that veterinarians should be able to discuss CBD with a client to ensure animal and public protection. That just makes sense, Penrod said. If a client comes in and says, Im going to use CBD on an animal, you should be able to talk to them about it, to warn them about some of the side effects, to watch out for those, to make sure that theyre purchasing a product thats been analyzed and it doesnt contain things like pesticides.

The AAVSB has created a task force to create guidance documents for regulatory boards concerning the issue of cannabis. Because things are changing so quickly, if we drafted regulations or practice law language, it could be out of date as soon as we published it. Guidance is a little more flexible, Penrod said.

Dr. Trina Hazzah is regularly questioned about cannabis use even though there are no cannabis products approved for therapeutic use in animals.

That is, clients frequently ask Dr. Hazzah, a veterinary oncologist working in Los Angeles whose area of interest is complementary and alternative medicine, about incorporating cannabis into their pets treatment protocols.

Dr. Hazzah, a founder and the co-president of the Veterinary Cannabis Society, offered her perspective on the therapeutic use of cannabis-derived products as part of the AVMA Cannabis Symposium.

As Dr. Hazzah explained, cannabis is primarily used with animals as an anti-inflammatory, analgesic, anti-anxiety, or anti-neoplastic. Prior to considering a cannabis product, the patient must first be evaluated to confirm that the animal has a potentially cannabis-responsive condition.

Does the patient have any contraindications or comorbidities that may prevent you from starting cannabis? Are there any potential drug interactions that you should be aware of? Dr. Hazzah asked. The next step is to evaluate the actual product as well as the product safety.

She cited a 2015 study that evaluated 75 edible cannabis products available in various California cities and found that just 7% of the products were accurately labeled for the cannabinoid content. In a follow-up session, Jack Henion, PhD, professor emeritus of toxicology at Cornell University, also conveyed results of a similar study where 12 of 13 animal products had greater THC levels than Canadas acceptable limits.

Its really, really important that clients do their due diligence and ask for a certificate of analysis, said Dr. Hazzah, who discourages clients from treating pets with cannabis products marketed for human illness.

You want to walk them through finding companies that are transparent, that have good customer service, that have up-to-date COAa certificate of analysisconfirming that the product is free of contaminants and that is very specific on what is in the product, she said.

Talk to clients about potential adverse effects and what signs to look for in pets, Dr. Hazzah added.

And then, lastly, you should set really clear expectations with a client, making sure that they know that cannabis is not necessarily a wonder drug, Dr. Hazzah explained.

Dr. Dharati Szymanski, an assistant director in the AVMA Division of Animal and Public Health and organizer of the summit, summarized the event thus: Our members hear varying perspectives from cannabis manufacturers, their state boards, regulatory agencies, colleagues, and, of course, clients. Sometimes it is difficult to see where these perspectives might intersect or how far apart they sit. Practitioners want to have confidence in the safety and efficacy of products. However, when the marketplace has outpaced the evaluation of products, veterinarians need to understand the potential benefits as well as risks surrounding these products for their patients and the liability risks for themselves. There has been much progress in bridging these gaps, but we need more work in areas of research, quality control, and FDA evaluation for veterinarians to have general confidence in available products.

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The hype and hope of veterinary cannabis - avma.org

Backyard poultry and small-scale livestock agriculture are a growing trend in the U.S., even in large cities such as Seattle, Portland, Denver and San Francisco. Residents raising backyard poultry and livestock do so for a variety of reasons such as access to locally sourced food, companionship and sustainability. But how often do these owners seek veterinary care in these urban and peri-urban areas (UPAs)?

A Western Regional team of collaborators, including UC Davis researchers, conducted a survey of veterinary practitioners to better assess their engagement with owners of these animals. They received responses from 880 veterinarians in California, Colorado, Washington and Oregon. Most respondents reported working in companion animal only or companion animal predominant practices. Although most of the veterinarians perceived an increase in backyard poultry and livestock in their practice areas, few were actively treating such animals primarily because of a lack of facilities, interest or experience.

Their findings, published in theJuly 15th issue of theJournal of the American Veterinary Medical Association, indicate an increasing demand for veterinary services for poultry and livestock in peri-urban areas, and a need for ongoing continuing education of practitioners, as well as the animal owners.

This segment of agriculture has been largely overlooked by the veterinary community in North America, said Dr. Alda Pires, University of California cooperative extension specialist in the UC Davis School of Veterinary Medicine and co-principal investigator in the study. Due to the potential for public health issues and the spread of zoonotic disease, veterinary professionals need increased training and better awareness of the health and welfare of these animals.

Dr. Ragan Adams, veterinary extension specialist at Colorado State University and a co-principal investigator emphasized that the animal owners also need better awareness of the importance of regular veterinary care and a willingness to pay for that medical expertise.

Many of these owners are unfamiliar with the responsibilities and challenges of owning poultry and/or livestock, Adams said. County Extension personnel can teach the new animal owners as they have taught youth in 4-H programs for more than 100 years. With enhanced knowledge about animal husbandry, the new owners will understand the importance of seeking veterinary services when their animals show signs of illness.

Disease spread from these peri-urban areas can spell disaster for other animals. For example, the 2015 outbreak of highly pathogenic avian influenza, traced to backyard poultry flocks, had severe economic and trade consequences for the commercial poultry industry. Recent outbreaks of virulent Newcastle disease in California also posed significant threats to commercial poultry flocks and the agricultural economy.

The health and welfare of animals in UPAs are of concern because their owners often lack the knowledge or expertise regarding safe handling and animal husbandry, said Dr.DaleMoore, Washington State University Veterinary Medicine Extension specialist and co-investigator.

A previous surveyfound that the owners want more access to livestock and poultry medicine. This follow-up survey highlights the need for veterinarians, along with extension specialists to work with small-scale poultry owners to improve biosecurity measures, better detect disease and mitigate potential future outbreaks.

The original study ideas for these surveys came from Washington State University Veterinary Medicine Extension (Drs. Dale Moore and Amos Peterson) as part of Petersons Masters Thesis project. The project was then extended to Veterinary Medicine Extension in California (Drs. Pires, Jerome Baron and Beatriz Martinez-Lopez), and at Colorado State University (Dr. Ragan Adams). Extension educators at Oregon State University and the Oregon Veterinary Medical Association helped with contacts in their states.

The increase in popularity of backyard and peri-urban agriculture provides both challenges and opportunities for veterinarians. Providing veterinary service to owners of backyard poultry and livestock, who often view their animals as pets rather than production animals, requires a different approach and some different skills than providing veterinary service to owners of conventional or commercial livestock operations.

Study authors suggest a new model of practice might be envisioned for urban and peri-urban poultry and livestock clientele to ensure the health and welfare of their animals, and to safeguard public health. Specific opportunities for the veterinary profession are to identify local or regional veterinary service needs for these owners, become equipped to address exotic or zoonotic disease detection and husbandry questions, and provide medical care as well as food safety advice.

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Study shows that veterinarians play a role in backyard poultry safety - Jill Lopez

A lot has been said about CBD pet products and their capacity to tame anxiety and other stressors that pets experience. Anecdotal evidence indicates that many pet owners are happy with the cannabis products theyve used on their pets, stating they put their pets at ease when theyre exposed to stressors like fireworks and separation anxiety. Pet owners feel a sense of comfort when using these products, since there are little to no side effects associated with them.

A cannabis symposium hosted by the American Veterinary Medical Association (AVMA)last month delved into the topic of veterinary cannabis, with different experts discussing its pros and cons.

We certainly recognize the potential opportunities that cannabis-derived compounds may offer and acknowledge the significant interest in these possibilities, said Randall Gnatt, a senior regulatory counsel in the Office of Surveillance and Compliance in the FDAs Center for Veterinary Medicine.

RELATED: The Relationship Between CBD And Owning Pets Is Deeper Than You Think

Were also aware that some companies are marketing products in ways that violate the federal Food, Drug, and Cosmetic Act and then may put the health and safety of people and animals at risk.

Waking up to this every morning would surely give you more will to live. Unsplash/jonathan daniels, CC BY-SA

While Gnatt made it clear that CBD is a promising compound for both humans and animals, he also expressed the FDAs concern regarding it, particularly in the way in which the cannabinoid has been advertised by dozens of companies. Other than the approved human prescription drug, we know little about the potential effects of sustained or cumulative long-term use of CBD, he said.

RELATED: Some CBD Pet Products Dont Actually Contain Any CBD

We dont know about coadministration with other medicines or risks to vulnerable human and animal populations. This doesnt mean that we know CBD is categorically unsafe under all circumstances, but given the gaps in our current knowledge and the known risks that have been identified, were not at a point where we can conclude that CBD products are safe for use.

CBD and cannabis remain largely unregulated. While significant steps have been made over the years to validate the medicinal claims of cannabis, much work needs to be done in order to get a full picture of the plant, especially if were giving it to animals who have no say on the matter and who might be better off visiting their veterinarian.

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What Pet Owners Should Know About Cannabis And CBD Products - The Fresh Toast

Global Veterinary Medicine Marketexpected to reach around US$ XX Bn by 2027, growing at a CAGR of 6.4% during the forecast period.

The MMR report includes various segments as well as an analysis of the trends and growth factors that are playing a substantial role in the market. These factors the market dynamics involve the drivers, restraints, opportunities, and challenges. Such as, The rise in the occurrence of contagious diseases among animals is driving the market for veterinary drugs. Animals also play a crucial role in research and development in studying drug therapy by performing preclinical trials in animals to develop advance drug and cost-effective veterinary drugs. Moreover, increasing awareness towards livestock and to cure zoonotic and chronic disease drives the market, rapid urbanization and an increase in per capita income drive the market growth.

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However, the discovery of complex diseases and various infections in humans from animals through the consumption of animal products such as bird flu, bird flu, rabies, coronova virus, and others and not giving street animals appropriately treatment restraints the market growth.

The report study has analyzed revenue impact of covid-19 pandemic on the sales revenue of market leaders, market followers and disrupters in the report and same is reflected in our analysis.

Opportunities:

Growing research and development investment to develop more effective drugs Rising meat consumption across the globe and animal-derived product like ghee, milk, butter give a better opportunity.

Global Veterinary Medicine Market: Market Segmentation:

The report covers the brief analytical segments of the veterinary medicine market thereby providing a wider view at the macro as well as micro levels. By route of administration, parenteral is dominating the veterinary medicine market and valued around US$ XX Bn in 2019. Parenteral administration is more preferred over other as it gives rapid onset of action, The better bioavailability, and reliable dosage and it gives fast therapeutic effect with rapid onset of action as it overcomes the first-pass metabolism whereas, several adverse reactions and painful delivery and discomfort are the drawbacks and hinder the growth.

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Pharmacies & drug stores segment is projected to witness the fastest growth during the forecast period. Because of the requirement and urgency in clinical for targeted medicines and to protect from zoonotic diseases and livestock animals.

Global Veterinary medicine market: Regional analysis

North Americas Veterinary medicine market was valued at US$ XX million in 2019 and is expected to reach a value of US$ XX million by 2027, with a CAGR of XX%. The major factors which are driving the growth of the Veterinary medicine market in the regions as it provides good animal welfare policies and its spend huge expenditure on research in veterinary medicine market especially the U.S and Canada. Since, North America is the developed region it consists of advance veterinary hospital and the large healthcare players and hence, take part in growing the economics of the market.

Europe is considered the second most promising market after North America in the Advancement of new techniques and growing healthcare agencies the European market is undertaken by Germany and Frances and so, drives the European market.

Recent Development:

In June 2018, Merck entered into a business with Vinovo B.V a division of Viscon Hatchery Automation. This has aided the company increase its portfolio of poultry vaccines.

The objective of the report is to present a comprehensive analysis of the Global Veterinary Medicine Market including all the stakeholders of the industry. The past and current status of the industry with forecasted market size and trends are presented in the report with the analysis of complicated data in simple language. The report covers all the aspects of the industry with a dedicated study of key players that includes market leaders, followers and new entrants. PORTER, SVOR, PESTEL analysis with the potential impact of micro-economic factors of the market have been presented in the report. External as well as internal factors that are supposed to affect the business positively or negatively have been analyzed, which will give a clear futuristic view of the industry to the decision-makers.

The report also helps in understanding Global Veterinary Medicine Market dynamics, structure by analyzing the market segments and project the Global Veterinary Medicine Market size. Clear representation of competitive analysis of key players by Application, price, financial position, Product portfolio, growth strategies, and regional presence in the Global Veterinary Medicine Market make the report investors guide.Scope of the Global Veterinary Medicine Market:

Global Veterinary Medicine Market, By Product

DrugsAnti-infectivesAnti-inflammatoryParasiticides VaccinesInactivated VaccinesAttenuated VaccinesRecombinant Vaccines Medicated Feed AdditivesAmino acidsAntibioticsGlobal Veterinary Medicine Market, By Route of Administration

Oral Parenteral TopicalGlobal Veterinary Medicine Market, By Application

Companion Animals Livestock AnimalsGlobal Veterinary Medicine Market, By End-User

Veterinary Hospital Veterinary Clinics Pharmacies & Drug StoresGlobal Veterinary Medicine Market, By Region

North America Europe Asia Pacific Middle East and Africa Latin AmericaGlobal Veterinary Medicine Market, key Players

Agrovet Market Animal Health American Veterinary Clinic Animalcare BASF India Ltd Belfarmacom Bimeda Biotex Plus Ltd Boehringer Ingelheim Gmbh Brouwer Cadila Pharmaceuticals Ltd Cargill India Pvt. Ltd Ceva Chemo Argentina Koninklijke DSM N.V Mars Merck & Co. Saudi Pharmaceutical Industries Sauvet Selecta Syntec The British Veterinary Center UCBVET Vetanco Veterinarski Zavod Subotica Vetmedica Wageningen Bioveterinary Research Wilbur-Ellis Zoetis

MAJOR TOC OF THE REPORT

Chapter One: Veterinary Medicine Market Overview

Chapter Two: Manufacturers Profiles

Chapter Three: Global Veterinary Medicine Market Competition, by Players

Chapter Four: Global Veterinary Medicine Market Size by Regions

Chapter Five: North America Veterinary Medicine Revenue by Countries

Chapter Six: Europe Veterinary Medicine Revenue by Countries

Chapter Seven: Asia-Pacific Veterinary Medicine Revenue by Countries

Chapter Eight: South America Veterinary Medicine Revenue by Countries

Chapter Nine: Middle East and Africa Revenue Veterinary Medicine by Countries

Chapter Ten: Global Veterinary Medicine Market Segment by Type

Chapter Eleven: Global Veterinary Medicine Market Segment by Application

Chapter Twelve: Global Veterinary Medicine Market Size Forecast (2019-2026)

Browse Full Report with Facts and Figures of Veterinary Medicine Market Report at:https://www.maximizemarketresearch.com/market-report/global-veterinary-medicine-market/54077/

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Global Veterinary Medicine Market- Industry Analysis and Forecast (2020-2027) by Product, Route of Administration, Application, End-User and Region....

Gucci, one of 4,000+ pet heroes treated at a PetCure Oncology cancer care center

West Islip, NY, Sept. 22, 2020 (GLOBE NEWSWIRE) -- Advanced radiation therapy for pets with cancer will soon be available in Long Island, New York following the announcement of a new collaboration between PetCure Oncology and the Veterinary Medical Center of Long Island (VMCLI) on Tuesday.

The new service is already accepting referrals from local veterinarians with an opening date less than two weeks away on October 5. Those interested in more information or the advice of a board-certified veterinary radiation oncologist can call 833-PET-HERO, a toll-free number dedicated to supporting pets with cancer and the families who love them.

Located in central Long Island in West Islip, VMCLI is the islands leading veterinary specialty practice and 24/7 emergency center. The addition of radiation oncology, combined with VMCLIs current oncology offerings, provides pet owners in Long Island with access to comprehensive cancer care all under one roof at VMCLI - a first for the island.

We are really proud to bring this level of cancer care to pets in Long Island, said Dr. Robert Composto, DVM, Co-Founder and Director of VMCLI. We are committed to both learning and providing cutting-edge veterinary medicine. Adding radiation oncology and partnering with PetCure keeps VMCLI at the forefront of cancer treatment for pets.

The program will be overseen by Dr. Rick Chetney, a New York native and one of nine board-certified radiation oncologists in the PetCure Oncology national network.

PetCure Oncology is a national brand that develops and manages radiation therapy centers featuring stereotactic radiation (SRS/SRT), the most advanced form of radiation therapy available. Already a proven care option for human cancer patients, SRS/SRT has become increasingly common in the treatment of pets with cancer. PetCure Oncology has supported this process by increasing access to SRS/SRT for pet owners, facilitating innovative clinical trials, and sharing data and research results from over 4,000 treatments to improve the impact of this therapy on survival times and quality of life.

At the most recent meeting of the Veterinary Cancer Society, PetCure Chief Medical Officer Dr. Neal Mauldin presented preliminary outcomes data that suggested SRS/SRT delivered with PetCure-developed treatment protocols is leading to better survival outcomes than other treatment options for at least nine specific tumor types. The list includes some of the most common types of pet cancer, most notably brain tumors, nasal tumors, osteosarcoma, mast cell tumors and melanoma.

Its great news that so many of our pets are still alive and thriving, so the data is still maturing, explained Dr. Mauldin, whose board certifications include radiation oncology, medical oncology and internal medicine. But objective analysis of the preliminary data at this point suggests that stereotactic radiation can be considered a standard of care for the treatment of many tumor types - much like it already is in human cancer treatment.

About PetCure Oncology: PetCure Oncology LLC is a marketing and management services company affiliated with PetCure Radiation Oncology Specialists (PROS), a veterinary healthcare provider with nine board-certified radiation oncologists that have treated more than 4,000 pets with cancer since 2015. Supporting eight treatment centers across the country and counting, PetCure also facilitates innovative telehealth services for both veterinarians and pet owners. For more information, contact a PetCure Pet Advocate at 833-PET-HERO.

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PetCure Oncology and VMCLI Fighting Pet Cancer in Long Island, NY - GlobeNewswire

Friday, September 18, 2020

Did you know that Drew Brees is a professor at the College of Veterinary Medicine? A pet professor that is, or rather pet professors.

The legendary football player is represented in the college in the form of two dogs, a Terrier mix named Drew and an Australian Shepherd border mix named Brees. Brees is owned by Dr. Ellen Lowery, director of the Purdue University Veterinary Hospital, while Drew is owned by Dr. Jim Weisman, assistant dean for student affairs.

As far as the name Drew goes, its basically my admiration for Drew Brees. Im a Boilermaker through and through, Dr. Weisman says. Drew is about nine-years-old and Dr. Weisman describes him as a very self-sustained dog. He enjoys playing fetch by himself by dropping a ball down a flight of stairs and bringing it back up to the top. Dr. Weisman says, for a dog, Drew is rather organized. He has his own toy box that he gets his things out of at the beginning of the day, but always brings them back and puts them away at the end of the day.

As for Brees, Dr. Lowery says, Im not the biggest football fan, but I have so much respect for Drew Brees. She says that Brees is about five-years-old and has a calm demeanor overall, but also is not afraid to act like a watchdog when she needs to. Dr. Lowery explains that when theyre home, She keeps all of the squirrels and chipmunks in line. When Brees is off-duty from her watchdog role, she enjoys being a greeter in the College of Veterinary Medicine. Students may find her in a hallway between classes always happy to be petted. Dr. Lowery says that students and staff love having Brees as a local mascot for the college.

Both of these dogs are involved in the colleges Pet Professor program. Animals in the program are often the pets of staff and faculty and provide a way for students to learn the foundations of conducting physical examinations and giving vaccinations to domestic pets as well as practicing ultrasounds and minor physical therapy techniques. Animals like Drew and Brees get a free examination while students get fun friends to play with and learn from, and who wouldnt want a teammate like Drew Brees!

Writer(s): Jonathan Martz, PVM Communications Intern | pvmnews@purdue.edu

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It's Not Far-fetched to Find Drew Brees in the College of Veterinary Medicine - Purdue Veterinary News