StemCell Therapy

Among Us and Fall Guys have been in a tussle to see who can capture more fans. As of now, Among Us seems to be the clear winner with the popularity of the game still rising. On the other hand, Fall Guys is seeing a steep, downward trend which is quite alarming for the game.

Regardless of its popularity, Among Us shouldnt be too quick to celebrate. The gaming industry is constantly innovating and really dynamic. Just like it rendered Fall Guys pretty irrelevant, there might soon come a game that would do the same to Among Us.

However, analyst Rod Breslau feels that there is one solution that would help both the games stay relevant for a long time. The idea would increase engagement among players.

Many games such as GTA 5 and Minecraft have involved the community in their development process. It is safe to say that a majority of them have seen rising engagement in players as well as a jump in sales. The freedom to include an element of ones creativity in the game always motivates fans. There is similar scope for both the games in question concerning their maps.

Popular streamer Shroud has already urged Fall Guys to add maps, especially if the game wants to stay in the race. It would make it so much easier for the developers to give that responsibility to the community.

This would allow the community to flaunt its creative side. Allowing players to make community maps will provide unlimited and constant new content for the game.

With limited maps and modes, the game becomes a bit repetitive after a while. This wont happen if they have unlimited access to new maps and tasks.

Not only is this Slashers opinion but that of many fans as well. They think that this something the developers should have included since the inception of the game.

While Among Us has other plans for the game to keep it interesting, Fall Guys needs to work on this stat!

It might not be that easy a task because it would require major changes in the game. Therefore, no matter how much criticism the game faces, it will still be a while until we are able to see those options come to the game. Till then, just like Among Us, Fall Guys too can work on other strategies to stay featured in the spotlight.

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Among Us and Fall Guys Can Ensure Longevity With This Feature - Essentially Sports

DANVERS, Mass.--(BUSINESS WIRE)--Health care costs are a major expense during the Womens Longevity Gap, the period in which a woman will need to cover expenses single-handedly after the death of a male spouse or partner, according to recent data from HealthView Services, the nations leading provider of health care cost projection software. The company estimates that in retirement an average, healthy 43-year-old woman will face nearly $200,000 more in health insurance premiums than her husband.

The company, which provides software for personalized health care cost projections to financial professionals, urges women and couples to start planning early to address the longevity gap.

HealthView Services encourages thoughtful, personalized planning for the disparities of age, income, and life expectancy that commonly exist among male/female couples. Recommendations include:

Following these steps, women and their financial advisors can mitigate and potentially even eliminate the longevity gap and the other challenges that are common among female retirees, said Ron Mastrogiovanni, CEO of HealthView Services. Financial advisors with the right tools and data at their fingertips have the power to help their female clients close that longevity gap.

About HealthView ServicesFounded in 2008, HealthView Services is the nations leading provider of healthcare cost projection software, built on a dataset of 530 million health care claims. Its portfolio of retirement healthcare planning applications centered on personalized longevity estimates and individual health care cost projections is used by advisors, financial institutions, employers and consumers to create comprehensive, reliable health cost projections for 33 million users annually. Visit us to know more: http://www.hvsfinancial.com.

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Women's Health Care Costs in Retirement Projected to be $200000 More than Men's - Business Wire

At 69.4 years, Indias life expectancy has made almost a 20 year leap from 49.7 in 1970-75. While this is no mean feat, the sobering reality is that Japan was here in 1960 and China in 1990. The link between poverty and life expectancy is fairly obvious looking at the India story. People in Delhi, Kerala, Jammu & Kashmir, Himachal Pradesh, Punjab, Maharashtra and Tamil Nadu with lower incidence of extreme poverty live longer than the national average. Poorer states like Chhattisgarh, UP, MP, Assam, Rajasthan, Bihar and Jharkhand drag down life expectancy.

Worries that Indias current economic difficulties are turning the clock back in the fight against poverty make life expectancy a key indicator to track. Countries like Nepal and Bangladesh had lower life expectancy than India in the 1980s, but they have now pulled ahead. Apart from the incidence of poverty, access to public health services could be an equally important factor separating Indian states. This is borne out by infant mortality and maternal mortality rates largely correlating with life expectancy. Keralas IMR is 7 per 1,000 live births, Delhis 13 and TNs 15 against 48 in MP, 43 in UP and 41 in Assam.

The Covid pandemic may be a short term phenomenon. But its effect on lives and health services has multiple dimensions with generational implications. State outreach like immunisation and supplemental nutrition schemes took a backseat this year. Treatments became harder to access, evident in statistics of fewer surgeries, procedures and OPD visits for heart diseases, cancer, TB etc. The loss of incomes and livelihoods will force many to scrimp on meals and protein-rich foods. A vigorous public health response to neutralise these setbacks is needed.

Total fertility rates have fallen sharply below replacement levels in most Indian states, barring a few like UP and Bihar. Coupled with better institutional services and families investing in fewer children, this could help reduce malnutrition and IMR. While the Centre is betting big on health insurance for the poor, this cannot substitute adequate doctor availability and healthcare infrastructure in rural areas. The neglect of public healthcare by successive governments has been extremely expensive for the country. While this must be urgently remedied, only a growing economy will enable the government to make these interventions and citizens to live longer and healthier lives.

This piece appeared as an editorial opinion in the print edition of The Times of India.

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Longevity gap: Poverty remains a scourge. India must focus on economy, public health - The Times of India Blog

Its not hard to see why yoga has become so popular. In addition to helping with strength, balance, and body awareness, its meditative qualities can help center your life and reduce stress and anxiety. Taking a yoga class with a professional yoga instructor is an absolute must since some moves can be dangerous if not performed properly.

Taking yoga as a group class, additionally, will allow for the meditative qualities of yoga to be enhanced by group participation and will give you the motivation to participate more fully in the spiritual aspects of the practice. Being a group yoga classalso allows you to benefit from the shared, collective energy of the group, and youll be able to leverage that energy throughout your yogic flows. For those who struggle to stay consistent with their yoga effortsparticularly beginnersthese classes can be a great way to create accountability, learn from others, and make it more fun.

Taking a group dance class can be an incredibly fun social experience, especially if you go with your significant other. Dance has many of the same advantages of yoga, including strength, balance, and cardio training, but instead of meditation, it concentrates on interpersonal interaction.

The social aspects of group dance go back to ancient traditions. All over the world, dance would have incredible importance in the ritual life of the community. Many of these ancient rituals have been lost, but some of those social benefits can be tapped into. Be it through swing, salsa, and other group dance classes. In fact, the ability to build close connections with your fellow dancers is one of the biggest benefits.

Because dancing involves physical connection, it allows you to bridge the gap between human interaction and human touch. Group dance classes are also almost always more affordable than private lessons, and youll benefit from getting a firsthand look at how many different people have different styles and approacheseven for the same dance.

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Top 5 Group Exercise Classes for Your Return to the Gym - Longevity LIVE

Its a diet thats really effective in weight loss and is a good diet for those that are currently severelyobese. Thererealso cases of the diet being really effective in dealing with type two diabetes, as many followersof this diet have been able to put the disease in remission, however, more evidence is needed on this front to determine its viability in combating diabetes.

The way the diet works is pretty simple. By drastically reducing carbohydrates and replacing themwith fat, yourbody is put in a metabolic state called ketosis.Being in this state makes your body really good at burning fat for energy, and this type of diet is also great at reducing blood sugar and insulin levels.

There are various forms of the Ketogenic diet. However, they all follow the main basic principle: fewer carbs and more fat. There is the Standard ketogenic diet, which can be broken down as 75% fat, 20% protein, and 5% carbs; High-protein ketogenic diet, which has a 15% increase in protein and a corresponding decrease in fat consumption; Cyclical ketogenic diet, which allows you to have two days a week of eating more carbs; and Targeted ketogenic diet, that allows you to add carbs around a workout.

When on a Ketogenic diet, there is only a certain amount of food you are permitted to eat. This includes meat, particularly red meat, and pork, as well as fatty varieties of fish like salmon, tuna, and mackerel. Eggs are good to have, as well as cheese like cheddar and mozzarella. Avocados are also very worthwhile food to eat on this diet, as there are lots of health benefits when it comes to consumingavocados.

It may sound strange, due to other diets encouragement of high fruit and vegetable consumption, but for the Keto diet, its critical that you avoid all fruit and root vegetables such as potatoes, carrots, and parsnips. Sugary food is also a no-go, as sugar is just a form of carbohydrates, which also means you should avoid wheat-based products like pasta. Its also important that you avoid alcohol, as due to its carb content you would turn the ketosis process off.

There are negatives tothis diet, however, and the main one is that for it to work, it needs to be followed strictly. If not, your body will fail to entera ketogenic state, meaning that youll actually store the fats youre eating, making you put on weight. It can also make you feel extremely tired and fatigued when you first start the diet, and could also see you get an increase of headaches and muscular pain.

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Finding The Right Diet To Eat For You and Your Body - Longevity LIVE - Longevity LIVE

Dry shampoos are taking the beauty world by storm. You can freshen up your hair quickly, although many products leave a white residue on your hair. Not with COLABs award-winning products, which is why we think you would love this review.

Unlike standard shampoos, dry shampoos require absolutely no water so its the perfect choice to freshen up hair quickly and on the go! Just spray, massage and style!

Frequent washing can strip your hair of natural oils, fade your color and cause split ends. Dry shampoo freshens up your strands without stripping them of their natural oils, allowing you to skip a hair wash day.

Thanks to its oil-absorbing formula, you can bid farewell to greasy, oily and dirty hair. Furthermore, dry shampoo adds more body and bounce to your tresses.

This product ticks the box on pricing as well, coming in at super value for money. Were not the only ones who think this product is great. If you know your beauty vloggers youll know Ruth Crilly from A Model Recommends. She is a beauty fanatic and international model and uses her website as a platform to share all the insider tips shes picked up during her decade long career.

COLAB is a multi-award-winning product range thats suitable for all hair types, colors, and textures.

To give your hair an instant fix, weve rounded up some of COLABs best sellers:

COLABS number one, the Original Dry Shampoo. The product will give hair an instant chic fix with an effortlessly cool vibe and sophisticated bergamot and rose scent.

Then if you are looking for the beach goddess feeling, then you will love COLABs Mermaid Dry Shampoo. Give your hair an instant fresh fix with modern-day mermaid vibes and a beachy, chic, mandarin, and driftwood scent.

COLABs incredible formula effectively absorbs oil and instantly refreshes roots with an invisible, lightweight finish. Hair feels clean, soft, and has a beautiful fragrance.

Whats more, COLAB is against animal testing, totally cruelty-free and vegan-friendly. These products come in a range of incredible fashion-forward fragrances created by a team of beauty industry experts

The formula uses tiny particles that, whilst absorbing excess oil and grease from the scalp, meaning that less product is sprayed onto the hair. Less product means absolutely no white residue.

You can count on your hair being refreshed and revived instantly. Better still without the hairs natural body and bounce being compromised.

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You Will Love This Dry Shampoo With No White Residue - Longevity LIVE - Longevity LIVE

I am writing in response to the Steamboat Pilot & Today article titled, The Longevity Project, Part 4 | Plants over pills: Non-traditional medicine growing in popularity, especially in Colorados mountain towns.

I first started my career in the medical realm as an occupational therapist and changed careers after my masters degree in social work.I have worked in the medical field in Steamboat Springs and currently own the integrated holistic clinic Minds in Motion.

I have been on both the conventional medicine side and also the holistic side with two different careers and love and respect both approaches.Anyone who knows me or what I have tried to give to this community for 18 years knows that I advocate strongly for the partnership of western/conventional medicine and holistic medicine.We must work together to give best practice of care and break the stigma of a right medicine.

I am responding to the article printed last week, because I believe the article was well intended but lacking in objectivity and information.Strained relationships and degrading comments about each side of medicine may be a little outdated, as there have been strong relationships between the two sides for over two decades, with many university hospitals now having alternative branches of care under their same roofs.

In our community of Steamboat, Minds in Motion works closely with physicians from all specialties including but not limited to pediatrics, orthopedics, family medicine, workers comp and internal medicine.Minds in Motion practitioners strongly recommend clients using their primary care physicians as part of their care plan.

Alternative medicine is a large category, and one must be careful when considering alternative medicine. The National Center for Complementary and Alternative Medicine is a branch of the National Institute of Health and has compiled thousands of peer-reviewed, evidence-based studies on effective alternative practices such as meditation, acupuncture, yoga and functional medicine.This medicine is put through the same rigorous reviews as western and conventional medicine and is often times hundreds, if not thousands, of years older than western and traditional medicine.If a client is looking for care, they should review the efficacy of every treatment regardless of what category it falls under.

Another aspect to consider when looking at your medical provider is level of education and where and how that provider is licensed for accountability of care.Sometimes, accountability is late in the game even on the conventional medicine side. For example, my degree of occupational therapy, which is currently a masters level of education, was only licensed in Colorado in 2008.Psychotherapists dont even need a masters degree to practice in the state of Colorado but can register through the state licensure anyway (ask your counselor for a disclosure of their education to cover this loophole).

At Minds in Motion, all alternative and holistic providers have a masters degree or higher of education from an accredited university and are licensed by a governing body. Dr. Fegley is an MD with additional certifications in functional medicine, and Dr. Grace Charles is an ND with similar educational demands as conventional medical school. It is for this reason we dont need to put quotation marks around doctor.

It only takes a couple minutes to do your homework to make sure your provider isnt a huckster. You can search for any licensed provider in the Colorado Department of Regulatory Agencies website athttps://dora.colorado.gov/.Some alternative medicine providers are still amazing even if they arent regulated by a governing body and can address the mind/body/spirit connection in a way that our culture doesnt value. Please remember that, but know your provider and ask the questions about their education or skills.

Angela Melzer, LCSW, OTR/LMinds in Motion owner

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Letter: We need to break the stigma of the 'right' medicine - Steamboat Pilot and Today

Even more encouragingly, evidence suggests that increasing our heart rate through exercise changes our brain chemistry, increasing anti-anxiety neurochemicals such as mood-enhancing serotonin.

If you dont usually make exercise a planned part of your day, it may be difficult at first to get the ball rolling, but the trick is to start small. You do not have to buy expensive equipment or join a high charging gym, simply schedule a time (perhaps on your lunch break, or when you get home from work) to go for a 30-minute walk. Once youve done this for a month, youll know youve cemented the idea of exercise time into your routine, and can be a little more ambitious perhaps booking a yoga class, or heading to the local swimming pool.

Whatever it is, by creating the time to be physically active every day even if its just engaging in a bit of enthusiastic housework or gardening you can enjoy all those mood-boosting brain chemicals and become that bit more mindful, learning to live in the moment with a bit more ease.

Research into the human microbiome (the vast collection of bacteria and fungi that live within our bodies, and most particularly in our gut) suggests that our digestive health has a surprising link to our mental health and that making certain food choices can help our mood. While a healthy diet looks different for everyone, some good tips are:

5. Actively practice gratitude and acceptance

Whether its a difficult divorce, impending redundancy, or a devastating pandemic, there are some events in life which cannot be solved in a way which we find constructive and satisfying, no matter how hard we try. And while everyone finds these situations hard to cope with, they can be doubly challenging for those who also live with anxiety. Sometimes we need to focus on simply getting to the other side of a rough patch rather than thriving, but we can make this easier by embedding habits into our life which increases our resilience and coping skills.

Within a daily journaling habit, we can acknowledge the things that are out of our control. We can also still explore productive strategies to mitigate their impact through the actions we can control. For example, if you are going through a breakup, you may not be able to control how your ex-partner feels and reacts, but you can use calming techniques like breathing exercises to respond to the situation in a way that you will later feel proud of.

A big part of this is a daily practice of acceptance and gratitude. The prayer from theologian Reinhold Niebuhr, Grant me the serenity to accept the things I cannot change, the courage to change the things I can, and the wisdom to know the difference may be oft-repeated, but its message rings true.

If we can learn through daily reinforcement to accept what we cannot change and to notice the things which we are grateful for (even if, on some bad days, its nothing but appreciating the small beauty of sunlight falling through a window) we can find anxiety in challenging situations easier to cope with.

Excerpt from:
Seven Daily Habits To Reduce Anxiety - Longevity LIVE - Longevity LIVE

Okinawa has the highest concentration of centenarians in the world, and the regional diet and lifestyle may be the key to Okinawans remarkable longevity.

Okinawa is the largest of the Ryukyu islands, which sit southwest of Japan between the East China and Phillippine Seas and near to Taiwan. The traditional Okinawa diet is high in carbohydrates, low in calories, and emphasizes locally grown plants and vegetables.

Overall, the diet is filled with nutrient-dense but low-calorie foods, resulting in a slight calorie deficit. Healthcare organizations such as the NHS recommend between 2000 and 2500 calories per day. While the typical, traditional Okinawa diet yielded approximately 11 percent less than the RDA. Several studies indicate that a minor caloric deficit may lead to improved overall health when combined with sufficient nutrients.

According to a report by Science Direct, Okinawa has 68 centenarians for every 100,000 residents. This is more than three times the number of centenarians found in comparable U.S. populations. More than 85 percent of the people who reach 100 years of age are women.

The Okinawa Centenarian Study (OCS), founded in 1975, has been investigating the life expectancy of Okinawa citizens over 100 for more than 45 years. By 2016, the OCS had examined 1,000 centenarians from the Okinawa region.

Okinawans have a high life expectancy, and many people also enjoy extremely good health well into their old age. Approximately two-thirds of Okinawas centenarians live independently until the age of 97. The islands oldest inhabitants also show little sign of cardiovascular disease. They also experience far lower rates of cancer, diabetes, and dementia than other comparably aging populations.

So what exactly does the Okinawa diet include? And why is it so healthy?

In the mid-20th centurywhen Okinawas current centenarians were young adultsthe typical island diet focused on home-grown vegetables, tofu, and small quantities of seafood. Approximately 60 percent of total calories came from a local, purple-fleshed variety of the sweet potato known as beni imo, as well as the white-fleshed tuber taro.

Beni imo, in particular, is an Okinawan staple. Restaurants, stores, and street food stalls all stock the bright purple potato. In Japan, there is even a beni imo flavored KitKat. In its natural form, it is extremely high in B vitamins and potassium and contains a higher concentration of the antioxidant anthocyanin than blueberries. Beni imo is also high in vitamin C, vitamin A, and has a low glycemic index that can help regulate blood sugar.

Overall, the Okinawa diet of the mid-20th century features what is now known as the Okinawan ratio of 10:1 carbohydrate to protein. While not technically a low protein diet, it still particularly emphasizes carbs. It also deprioritizes animal-derived proteins such as seafood and red meat.

By as early as the late 19th century many Okinawan households kept a family pig. But pork products were and are mostly eaten in moderation or as celebratory foods. Meat and seafood make up just 2 percent of the traditional islander diet.

While informed by a variety of neighboring countries and cultures, Okinawan cuisine is singular. Many of the regions popular dishes are completely unique to the archipelago. Chanpur, a popular stir-fry, combines tofu with a small portion of vegetables, meat, or fish.

Variations may include gy, a bitter melon, along with thinly sliced pork or spam. While not meat-free, this dish notably emphasizes plant foods and vegetables as the heart of the meal.

Cabbage, okra, pumpkin, and daikon radish are also popular ingredients. These types of vegetables make up approximately 60 percent of the traditional Okinawan diet. Grains such as wheat, millet, and rice make up 33 percent. While soy-based foods such as tofu, miso, and edamame make up 5 percent.

Because of its location, the Pacific archipelago of Okinawa blends cuisine and cooking styles from China, Southeast Asia, and Japan. Both Okinawa and Japan have food-centered cultures, while the concept of food as medicine is commonplace in China.

The Okinawa diet incorporates this, particularly through its use of herbs and spices thought to have medicinal properties, such as turmeric. The vibrant yellow or orange spice contains curcumin, which some studies indicate has significant anti-inflammatory properties. It may also lower the risk of heart disease and Alzheimers.

While there are a variety of different factors that contribute to longevity, access to healthy food does significantlyand demonstrablyimpact health. According to the Physicians Committee for Responsible Medicine (PCRM), plant-based whole foods can prevent and treat many chronic health conditions, such as inflammation and diabetes.

The traditional Okinawa diet includes seaweed, particularly kombu and wakame. Both varieties are rich in vitamins and known to reduce blood cholesterol and hypertension. Wakami is also high in iodine, iron, and calcium, along with vitamins A and C. Much like the beni imo, wakame can help regulate and maintain blood sugar levels.

The modern Okinawa diet still emphasizes traditional foods, but westernization and other factors have led to an increase in the consumption of meat, processed food, and refined sugar. By the year 2000, the risk of heart disease and other health concerns had risen significantly.

While there is no magic wand for long life, research increasingly indicates that emphasizing plant-based foods, whole grains, and unsaturated fatsalong with an active, healthy lifestylecan support personal health and even longevity. Much like the diets found in any of the other so-called Blue Zones around the world.

Blue Zones are regions where the local population lives longer than the global average. National Geographic fellow, author, and explorer Dan Buettner first coined the term in 2004.

Specific Blue Zone regions include Icaria in Greece, Sardinia in Italy, the Nicoya Peninsula in Costa Rica, Loma Linda in California, and Okinawa. While diets in these regions naturally vary, there are a few common factors. Including a particular emphasis on carbohydrates and plant foods.

Beans and legumes are also widely thought to support longevity. As is limiting the consumption of red meat in favor of small quantities of fish or plant proteins. Not overeating, and consuming the bulk of the days calories in the morning and afternoon may also contribute to a longer life.

Plant foods are high in fiber, which significantly reduces the risk of cardiovascular disease and certain cancers. While the natural estrogens in tofu and other soy products, flax, legumes, and broccoli are thought to contribute to the longevity of Blue Zone and Okinawan women, in particular.

There are other cultural and social factors in longevity, too. In Okinawa, consistent and supportive social interaction may contribute to the islanders health. A moai is a lifelong circle of friends that supports each other into old age. This concept comes from the ancient practice of yuimaru, or mutual aid, which helped support community members with the greatest need.

Now, Okinawans form moai as supportive social groups, but members continue to support one another as much as possible. Loneliness has a significant impact on physical and mental health, and studies indicate that tight-knit communities and regular socializing can reduce depression in older people.

The Mediterranean and other Blue Zone regions also emphasize both socializing and staying active within the community. Exercise, regular time with others, and healthy eating intersect and provide overall health improvements.

Read the rest here:
Is the Okinawa Diet the Secret to a Longer Life? - LIVEKINDLY

DILLON Never give up. Dont dwell. Have a sense of humor. And get a dog.

Thats advice for overcoming hardships from those who know how: Summit Countys overcomers people whove experienced tragedy, injury or rare conditions and have persevered to live happy and healthy lives in the High Country.

The Summit Daily News asked readers to nominate community members who have overcome a challenge and continue to live life to its fullest. Nominations included everything from sustaining a traumatic brain injury and surviving sepsis to suddenly losing a spouse or overcoming alcoholism.

From 70 nominations, the Summit Daily chose three people to share their inspirational stories of recovery.

Dave Repsher

On July 3, 2015, the Flight for Life helicopter in which Dave Repsher was riding crashed shortly after takeoff at St. Anthony Summit Medical Center in Frisco. The crash caused the helicopters fuel tank to rupture, spilling fuel that burst into flames.

PilotPatrick Mahany was killed, and Flight for Life nurses Repsher and Matt Bowe were severely injured. Repsher suffered full-thickness burns to 90% of his body and was not expected to survive.

His survival defies all medical statistics, Daves wife, Amanda, said.

After 397 days in the hospital, countless surgeries, physical therapy, dialysis and a kidney transplant, Dave and Amanda returned home to Silverthorne in September 2018.

Almost three years later, we finally were able to move back home, and that was our goal, just to get back into this wonderful community, said Dave Repsher, who grew up in Summit County.

The Repshers have turned the tragedy into advocacy. The couple now work to support burn survivors and create awareness about organ donation. Theyve also partnered with Karen Mahany, the wife of the pilot who died in the crash, to advocate for stronger flight safety standards.

Believe it or not, 85% of the fleet still doesnt have a crash-resident fuel system, Dave Repsher said, adding that all newly manufactured helicopters are now required to come off the line with a crash-resistant fuel system.

More than five years after the crash, the couple said they couldnt have done it without the help of the community.

The community had our back, Dave Repsher said. The support and love we got from this community was really what pulled us through.

Through it all, he believes his mental strength helped in his recovery.

For whatever reason, I just didnt dwell on what occurred, he said. I just kept looking forward. I had goals, whether they were realistic or not. But it just gave me something to look forward instead of looking back. And its not always easy to do, but for me, I think thats what got me through.

Doris Spencer

Doris Spencer was 7 years old when she fell while ice skating and injured her back. Her injury was not diagnosed until her legs went numb and she collapsed while standing in line at a bank more than 25 years later.

Her orthopedic surgeon said she had severed her spinal cord and performed a 13 1/2-hour operation. Though her doctors said the surgery was successful, Spencer couldnt walk.

My legs didnt know what to do, she said. It was just very scary.

She dragged her legs behind her walker for two weeks in the hospital before going home. There, she was assigned to walk around the block four times a day while trying to get her brain to tell her legs what to do.

After eight months, my left foot actually moved one-half inch all by itself, she said. And I just could not believe it. And so I knew I would be able to walk again.

A couple of months later, she said she was able to walk on a hard, flat surface with the help of two poles. About two years into her recovery, she moved to Summit County.

Her home was at the base of Quandary Peak, and the mountain served as the inspiration she needed. She slowly learned to walk on uneven surfaces and later succeeded in climbing the 14,000-foot peak.

I fell down at the summit and just cried my heart out for about 5 or 10 minutes, she said.

She and partner Kent Willoughby whom she described as the love of my life went on to climb all the 14ers in Colorado followed by summiting the 100 tallest mountains in the state. They then set their sights outside of Colorado, tackling the tallest peak in each of the 50 states accomplishing all but Denali.

We were successful in that except for one, and that was in Alaska, Spencer said. The weather wasnt right, and you just cant climb a big mountain like that unless the weather is right.

For her recovery, Spencer thanks her doctors and God.

I am so grateful for them allowing me to be able to do what I do after what Ive been though, she said. Every day is a blessing for me.

Joe Pleban

After being diagnosed with a rare joint disease in high school, Silverthorne resident Joe Pleban said thousands of tiny tumors ate away at the cartilage in his left ankle and left him with severe arthritis.

I was slowly losing the ability to play all these sports like rugby, wakeboarding but the one sport I could always still hold onto was snowboarding, Pleban said. And then eventually, I lost the ability to snowboard.

And I was like 20 years old, walking with a cane.

Doctors suggested fusing the bones in his ankle, but he would never be able to play sports again.

Well in that case, you might as well just cut it off and give me an awesome robot leg that I can play sports on, Pleban recalled thinking.

Pleban calls himself an elective amputee, meaning he chose to have his foot removed so he could pursue an active lifestyle.

After he made the nerve-wracking decision, he and his wife, Johnna, made a bucket list for his left foots final days. They went skydiving, scuba diving and paint balling. And before he went in for surgery, he completed one last bucket list item: getting a tattoo.

The scissors and dotted line around his left ankle and the note please cut here gave his doctors a chuckle.

If its getting cut off anyways, might as well get a tattoo on it, he joked.

But his amputation was just the beginning of another debilitating problem: phantom pain caused by sensory nerves.

Pleban said he was on a ton of pain meds until an experimental clinical trial surgery took away his pain. Now, that surgery targeted motor reinnervation is considered the first proven cure for phantom pain, he said.

Overall, it was incredibly successful, he said.

With his pain subsided, it was time to move onto the next goal: getting back on a snowboard.

Its always been my dream to represent the U.S. on an international stage, Pleban said.

He said he got his butt kicked at one of his first competitions, the USASA nationals for adaptive snowboardcross at Copper Mountain Resort.

If these guys are riding on a prosthetic at that level, I can do it too, he said he told himself at the time.

Last season, he was named to the U.S. Para Snowboard Team. Hes been named to the team again this season and is looking forward to competing in whatever form that takes during the pandemic.

Through the pain and difficult times, Pleban has relied on humor to lighten the mood, joking that he gets 50% off pedicures and only stubs his toe about half the time.

Its going to suck. Its going to be serious to have to overcome something, Pleban said about his advice for others who are struggling. To introduce humor helps to take away the seriousness of it, even just for a short time.

Its not going to be easy, but it helps.

Editors note: Join the Summit Daily News at 6 p.m. Wednesday, Sept. 30, for The Longevity Project event featuring speaker Sean Swarner, a two-time cancer survivor with one functioning lung who climbed Mount Everest. The event is free to attend, but registration is required at SummitDaily.com/longevity. Those who register can also watch the Overcomers panel discussion.

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Summit County overcomers: Inspirational stories of healing and hope - Summit Daily News

How does Botulinum Toxin work?

The whole Botulinum Toxin mechanism consists of blocking nerve signals in the muscles or paralyzing them. Naturally, the nerve endings release a special chemical substance acetylcholine. This chemical serves as a connector between nerve endings and cells of a muscle.

This substance forces the muscle to contract. Botulinum toxin injectionshelp to block acetylcholine release and decrease muscle activity, so muscles could be less stiff. Therefore, if the muscle is not able to contract, the skin will not be able to wrinkle.

However, there are some key differences between the medical and cosmetic use of Botox. Usually, for cosmetic purposes, injection doses are smaller and weaker. Botox injections help to get rid of facial wrinkles. The main goal of the injections is to correct appearance. Therefore, it is very helpful in eyebrow lifting, as well as eliminating fine lines around the lips. It also helps chin dimpling from overactive muscle movement.

Read more from the original source:
What Botulinum Toxin (Botox) Is and Its Benefits for Health - Longevity LIVE

A new preliminary study involving more than 5,000 genetic sequences of the coronavirus suggests one of the viruss many mutations may be more contagious than the others, according to a report from The Washington Post.

The study, which has not been peer-reviewedand was conducted by researchers from Houston Methodist Hospital, found the strain known as the D614G mutation was responsible for close to every coronavirus infection in Houston this summer, during Texass second wave of infections.

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The mutation did not make the virus deadlier or change clinical outcomes, according to researchers.

All viruses mutate and most of the random changes to the genetic sequence are considered to be insignificant, however, researchers found people infected with this particular strain had higher viral loads in their upper respiratory tracts, allowing the virus to potentially spread more effectively.

David Morens, a virologist at the National Institute of Allergy and Infectious Diseases who reviewed the study, told the Post the findings suggest the virus may have become more contagious and could possibly be responding to health measures such as social distancing and mask-wearing.

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Wearing masks, washing our hands, all those things are barriers to transmissibility, or contagion, but as the virus becomes more contagious it statistically is better at getting around those barriers, Morens told the newspaper, cautioning not to over-interpret the findings from a single study that has yet to be peer-reviewed.

He also said its possible the virus could eventually get around immunity when a vaccine is rolled out, similar to the flu.

Although we dont know yet, it is well within the realm of possibility that this coronavirus, when our population-level immunity gets high enough, this coronavirus will find a way to get around our immunity, he said. Well have to chase the virus and, as it mutates, well have to tinker with our vaccine.

The research is the latest in a series of studies suggesting the D614G mutation is more contagious than earlier versions of the original virus. The mutation has been dominant in almost all places in the U.S., Europe and Latin America.

A report last month claimed the mutation may be more infectious but less deadly than the original virus, as it has been associated with lower death rates.

But other researchers said the conclusion that the mutation is more contagious than others is premature.

The study provides more evidence for what we already know about this mutation: That its the most common variant, Emma Hodcroft, a geneticist at the Nexstrain project, told Business Insider. That doesnt mean the virus is effectively mutating.

Hodcraft said her team of researchers that has been tracing the coronaviruss genetic changes have yet to identify a mutation that would change how infectious or deadly the virus is, according to Business Insider.

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View post:
Coronavirus mutation emerges that may outmaneuver mask-wearing and hand-washing | TheHill - The Hill

Results from a preliminary study out of South Korea shows 9 out of 10 coronavirus patients reported experiencing at least one side effect of the disease after recovery, Reuters reports.

An online survey of 965 recovered COVID-19 patients conducted by the Korea Disease Control and Prevention Agency (KDCA) foundmore than 90 percent of respondents reported experiencing side effects associated with the disease, such as fatigue, loss of sense of taste and smell and psychological effects.

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The survey found fatigue was the most common reported side effect, with 26 percent of recovered patients reporting experiencing tiredness, followed by difficulty in concentration.

KDCA officials said the study will soon be published with detailed analysis, according to Reuters.

The study comes as health officials are raising concerns about the long-term side effects of the virus that has infected more than 33 million people and left more than 1 million dead around the world.

During a congressional hearing last week, Anthony Fauci warned of a growing number of people experiencing health issues weeks, and in some cases even months, after they thought theyd beaten the disease.

Theyre referred to as long haulers, Fauci, the director of the National Institutes of Allergy and Infectious Diseases said.

He said recovered patients have reported experiencing fatigue, myalgia, fever and the inability to concentrate. Many patients who have appeared to have recovered were found to also have inflammation of the heart.

As many as one in three COVID-19 patients may develop lingering symptoms, according to the Centers for Disease Control and Prevention.

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Read more:
90 percent of coronavirus patients experience side effects after recovery, study finds | TheHill - The Hill

With wildfires, extinction events, rising sea levels, and, oh yeah, the pandemic, sometimes it can truly feel like the universe is coming to an end.

Scientists do mostly agree that the universe is indeed ending although those other events have nothing to do with it.

And while we're not yet sure exactly how the universe will meet its demise, or even when it will happen, astrophysicists like Dr. Katie Mack are trying to figure all that out.

She's been gathering data from the latest astronomical observations and particle experiments to figure out the messy, chaotic, and mind-bending ways that the cosmos could come to a close.

Bob McDonald spoke with Katie Mack about her book The End of Everything (Astrophysically Speaking).

This interview has been edited and condensed for clarity.

How do we even know that the universe will come to an end?

We have a pretty good idea. We know the universe had a beginning and we know that because we can actually see the leftover light from the big bang itself. And we know the universe has been evolving over time. We know that it's been changing, that the way that stars form, the way that galaxies evolve, that's all been changing over time. We know that the expansion is continuing and it either continues, or it turns around, or it stops.

And there's no sense in which it just kind of stays as it is. And all of those changes lead to different kinds of possibilities for the end. But they all do have an end.

Take me through the main ways that you see the universe ending.

There are five different possibilities I cover in the book, and I use those five because they are a reasonable selection of the kinds of things that we talk about as physicists. So there's the Big Crunch where the universe collapses on itself, the Heat Death where it expands forever and just gets colder and kind of dies out. There's the Big Rip where the universe rips itself apart. There's Vacuum Decay, which is a wild idea where the universe basically succumbs to an instability built into space itself. And then there's Bouncing Cosmologies where you have some kind of ending and beginning cycling over and over again.

Do you have a favourite version?

I do. My favourite is Vacuum Decay. I should say the one that's most likely, based on our current data and the one that's most accepted by physicists, is the Heat Death, where things just kind of fade away in the future. And that seems like it's likely to happen. It would be a very long time from now. So it's a very gentle kind of fading away, but it's not the most exciting.

And I think that the Vacuum Decay scenario does bring some possible excitement to the story because it's a very sudden and very complete ending, and it comes out of our understanding of particle physics in this way. That brings together weird things we're learning about particle physics, and something that has an effect on the entire cosmos. And so it's a very cool thing from a physicists perspective. But it's also cool because it's very dramatic and sudden and in principle could happen sort of at any time. We don't think it's going to happen soon, but it could take a while. It's very unlikely. And that brings some more excitement.

Now, another ending to the universe that you bring up in your book is called The Big Rip. Take me through that. What happens?

Sure. The Big Rip is basically a worst case scenario about dark energy. Dark energy is this mysterious stuff that's making the universe expand faster. So right now, we know that the universe is expanding, and that means that galaxies are getting farther apart from each other. There's more empty space and every galaxy in the universe is going to get more and more isolated over time until everyone is kind of alone in their own little pool of light and the rest of the universe is dark.

But if dark energy is a little bit more powerful than we expect, then not only will galaxies be isolated, but eventually that dark energy is going to stretch out more than just empty space. It's going to stretch out matter itself. It's going to build up and sort of pull apart galaxies, pull stars away from their galaxies, pull planets away from their stars. And in this kind of very violent finale of the Big Rip, it would actually rip apart the fabric of space itself. That's a scenario that is probably not very likely. If that's going to happen, we're really sure it's not going to happen for at least about 200 billion years.

What could happen after our universe has ended?

It depends on how it ends, and it depends on whether it's embedded in some larger space, some larger universe or multiverse that's out there. There are a few ideas for a universe that comes out of a larger space, where maybe our universe and other universes could have sort of sprouted out of this much larger space, then those other universes would be separate enough from ours that we wouldn't interact with them, but they could exist sort of alongside or before or after our universe. And then there are these cyclic models where a previous universe ended, and in the process of it ending, it set the scene for our universe and sparked the beginning of ours, and then ours might end and spark a new one.

But there are also possibilities where basically when it ends, our universe could be destroyed in such a way that we don't know how something could come after that.

Can humans have any effect on the way the universe ends, either by making it happen sooner or could we even stop it from happening and live longer?

Humans affecting the evolution of the universe seems very unlikely for a couple of reasons. One is that we don't have technology that can influence the shape or behaviour of space time at the moment. But also when we look at what the universe is made of, most of the matter in the universe is this invisible dark matter that we don't understand, and we can't see. And most of the stuff just in general of the universe is this dark energy, which is also invisible. And when you add up dark matter and dark energy, that's 95 percent of what the universe is made of.

And so only five percent of the universe is even stuff that we can see or touch or interact with. Even the kind of matter that we're made of is only about five percent of the universe. And then we're just a tiny speck on top of that. We're just one species on one planet around one star and one galaxy. And there are maybe two trillion galaxies in the observable universe. So the idea that we're significant enough to affect the evolution of the cosmos seems very unlikely.

But I think that insignificance is actually kind of inspiring in some ways, because even though we can't do anything, we can't affect the evolution of the cosmos, we have this amazing power to understand it. And even being as insignificant as we are, we have an amazing comprehension of the cosmos, and we've learned so much. And I think that's a really amazing thing about us as a species.

Produced and written by Amanda Buckiewicz

More here:
Five ways the universe might die including one that could happen at any time - CBC.ca

The Diabetic Neuropathy Market report defines and briefs readers about its products, applications, and specifications. The research lists key companies operating in the market and also highlights the key changing course adopted by the companies to maintain their strength. By using SWOT analysis and Porters five force analysis tools, the strengths, weaknesses, opportunities, and commination of key companies are altogether referenced in the report. Every single leading player in this global market are profiled with details such as product types, business overview, sales, manufacturing base, contestant, applications, and specifications.

Diabetic Neuropathy Market has witnessed continuous growth within the past few years and is projected to grow even more throughout the forecast. The analysis presents a whole assessment of the market and contains Future trends, Current Growth Factors, attentive opinions, facts, historical information, and statistically supported and trade valid market information.

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Manufacturer Detail: Eli Lilly and Company, GlaxoSmithKline, Pfizer, Johnson & Johnson and Janssen Pharmaceuticals.

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Regional Analysis ForDiabetic Neuropathy Market

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Diabetic Neuropathy Market Research Methodology :

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The Report Answers the Following Questions:

Get Full Report Description, TOC, Table of Figures, Chart, etc. @ Diabetic Neuropathy Market

The complete profile of the companies is mentioned. And the capacity, production, price, revenue, cost, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies, and the technological developments that they are making are also included within the report. In the end Diabetic Neuropathy Market Report delivers a conclusion which includes Breakdown and Data Triangulation, Consumer Needs/Customer Preference Change, Research Findings, Market Size Estimation, Data Source. These factors will increase the business overall.

Thanks for reading this article; you can also get individual chapter wise section or region wise report version like Asia, United States, Europe.

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Diabetic Neuropathy Market Expected to accelerate the growth of the industries forecast 2020-2026 - The Daily Chronicle

If you or a senior you know needs help during this time, please do not hesitate to call the SCV Senior Center at (661) 259-9444. You can also visit their website by clicking here. They remain dedicated to doing everything they can to help while following the latest guidelines from the CDC and LA County Health Officials.

Hosts: Dr. Gene Dorio & Barbara Cochran

Topic:Getting Real Results Treating Neuropathy

Guests:Dr. Thomas Polucki, DC

Click here to listen to the full show!

Right click here to download the podcast and take it with you!

Join Barbara Cochran and Dr. Gene Dorio every Wednesday from 11 a.m. to Noon on your Hometown Station KHTS 98.1 FM & AM 1220 for The Senior Hour, your home for Senior Care and Lifestyle.

On this episode of The Senior Hour with Dr. Gene Dorio and Barbara Cochran, Dr. Thomas Polucki, DC, comes in to the studio to talk about getting real results treating neuropathy. To participatein a free telehealth webinar on peripheral neuropathy hosted by Dr. Polucki, you can register by clicking here.If you would like to schedule an appointment with Dr. Thomas Polucki or find out more about the services he offers, you can do so on his website by clicking here.

Listen to the full show by downloading the podcast by clicking on the links above and by listening on Facebook at KHTS Radio or by clicking the Play button in the box below!

The Senior Hour 09/23/20

It's time for this week's episode of The Senior Hour with Dr. Gene Dorio and Barbara Cochran. On this episode, Dr. Thomas Polucki, DC, joins Barbara and Dr. Dorio in the studio.

Posted by KHTS Radio on Wednesday, September 23, 2020

Barbara Cochran has been a resident of the Santa Clarita Valley for over 40 years and has spent much of that time volunteering with and creating a variety of organizations. The 1983 SCV Woman of the Year brings senior news to you every week on your Hometown Station.

Dr. Gene Dorio, M.D. has practiced Internal Medicine in the SCV since 1988. A member of the medical staff at Henry Mayo Newhall Memorial Hospital, he is very active in local senior affairs.

As Santa Claritas only local radio station, KHTS broadcasts a combination of news, traffic, sports, and features along with your favorite adult contemporary hits.Santa Clarita news and featuresare delivered throughout the day over our airwaves, on our website and through a variety of social media platforms. Our KHTS national award-winning daily news briefs are now read daily by 34,000+ residents. A vibrant member of the Santa Clarita community, the KHTS broadcast signal reaches all of the Santa Clarita Valley and parts of the high desert communities located in the Antelope Valley. The station streams its talk shows over the web, reaching a potentially worldwide audience.Follow @KHTSRadio onFacebook,Twitter, andInstagram, and sign up forKHTS email and text alertstoday!

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The Senior Hour - Getting Real Results Treating Neuropathy - 09/23/2020 - KHTS Radio

Nilanjan Ghosh, MD, PhD, a medical oncologist at Levine Cancer Institute, Atrium Health in Charlotte, NC, discussed the case of a 22-year-old patients with advanced Hodgkin lymphoma.

Targeted Oncology: What is your assessment of the patient?

GHOSH: The patients serum albumin is 4.2 g/dL, so thats an issue. The fact that she has stage IV disease, and that the white cell count was high, and the lymphocyte count was low are factors leading to an International Prognostic Score [IPS] of 4. The 5-year overall survival for high IPS, based on historical data, is not as good. I dont know if this would apply as much now, but this is what we have if we use the historical data. That suggests that she is a higher-risk patient. To be honest, the IPS has not affected treatment choice as much, at least in the United States, but well see if some of the newer treatments such as brentuximab vedotin [Adcetris] plus doxorubicin/vinblastine/dacarbazine [A+AVD] have any effect on that subgroup.

What do the National Comprehensive Cancer Network guidelines recommend for stage III or IV disease?

There are 2 treatment pathways that can be followed in patients who have stage III or IV.1 One focuses on a PET-adaptive pathway, which is ABVD [adriamycin, bleomycin, vinblastine, dacarbazine], followed by AVD [adriamycin, vinblastine, dacarbazine] or BEACOPP [bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone]. The non-PET adaptive therapy is the other pathway and uses brentuximab vedotin and AVD or escalated BEACOPP. Escalated BEACOPP is not usually used in North America.

Which regimen was chosen in this patient?

The patient was treated with brentuximab vedotin and AVD. Interim PET scan shows a Deauville score of 3; the patient tolerated this regimen well with G-CSF support. I think most people are certainly familiar with the Deauville scoring system, so just remembering that if the uptake is less than the liver, that is considered as grade 3 response. If its uptake is moderately above or markedly above, then thats considered progressive.

What are the key findings of the ECHELON-1 study (NCT01712490)2?

ECHELON-1 evaluated brentuximab and AVD versus ABVD. The standard of care is ABVD. The most important thing to note is the dose of brentuximab, which is 1.2 mg/kg, not 1.8 mg/kg, because this is given every 2 weeks. Its mirroring when ABVD is administered.

[This was a] large study with [more than] 1200 patients. It examined patients with stage III or IV classical Hodgkin lymphoma who had relatively good performance status. The investigators did allow patients to enroll if they had measurable disease and adequate liver and renal function. There was a PET scan at the end of cycle 2; however, this was not a PET-adaptive therapy. ABVD was given for 6 cycles. There is no decrease to AVD or escalation to BEACOPP

At 3 years, the progression-free survival [PFS] rate was 83% in the treatment arm and 76% in the control arm. This is highly significant, with a P value of .005, a hazard ratio of 0.7.

Overall, subgroup analysis favors brentuximab and AVD. But the confidence intervals do cross over in some categories, especially in the regional subgroup. For some reason, ABVD seems to do better in Asia. The study, though, is not powered to determine if 1 region is better than another. So, you have to take this kind of data with a grain of salt.

Now, remember this patient was young; shes in her early 20s. In a younger age group, the A+AVD did better than ABVD. She lives in North America, so thats a region where ABVD did better. And then looking at the IPS, she had a score of 4, and thats another group in which A+AVD did better.

In general, A+AVD would probably be favored in stage IV disease. Her symptoms are associated with having extranodal sites, and in our case, the patients extranodal site was associated with the bones. Her performance status is good.

Looking at the responses in ECHELON-1, the overall response rate was 86% versus 83%, so there are small differences.

Regarding adverse effects [AEs], remember that when we think about brentuximab, we think of peripheral neuropathy. In the study, peripheral neuropathy was 67% for the treatment arm versus 42% in the ABVD arm. For diarrhea, its 27% versus 18%, and abdominal pain was slightly higher in ABVD, as well. In terms of any AEs, theyre similar; grade 3 events were more for A+AVD versus ABVD.

I will mention that initially in the protocol there was no mandate for growth factor, so most patients were treated without growth factors. There were increasing incidences of neutropenia and neutropenic fevers in the A+AVD arm. Protocol amendments were performed later and G-CSF support was introduced. It was the middle part of the program. The guidelines recommend that A+AVD should be used with G-CSF support. But the protocol for the most part didnt initiate G-CSF support except toward the end. So, we see 83 patients who [received] G-CSF support and 579 who didnt.

In terms of serious AEs, there were more associated with A+AVD. The reason I bring that up is because the majority of that protocol was already carried out without the G-CSF support. The treatment group ended up seeing more AEs and clearly there are more incidences of neuropathy with A+AVD. Drug discontinuation, however, was about the same between the groups. Deaths during treatment [were] very low, and there were more hospitalizations observed with A+AVD.

Did investigators initiate any dose delays?

Most of the dose delays were initiated because of neutropenia and febrile neutropenia. For patients who discontinued more than 1 drug because of AEs, 7% were attributed to peripheral neuropathy, which is an important AE in this treatment.

Regarding pulmonary toxicity, we would expect a bleomycin-containing regimen would have higher pulmonary toxicity. It was seen in 7% of patients with ABVD and 2% with A+AVD,

and grade 3 or more pulmonary toxicity was low in A+AVD but observed in 3% of patients with ABVD.2

How were febrile neutropenia and any neutropenia addressed in the trial?

We see a difference between patients who [received] G-CSF support versus those who didnt, regarding febrile neutropenia versus any neutropenia. In patients who developed febrile neutropenia during treatment, 11% of those who received G-CSF support experienced the AE, and 21% who did not receive G-CSF support experienced the AE.

For neutropenia any grade, 73% of patients who did not receive GCSF versus 35% of patients who did receive G-CSF support developed it. Similarly, for grade 3 or more neutropenia, 70% who did not receive G-CSF versus 29% of patients who did developed it. To me, that is the most striking observation.

In the ABVD arm, there was neutropenia observed with ABVD, and we all have had patients with ABVD where the absolute neutrophil count is low, and we still go ahead and treat. That is done in standard practice.

In terms of serious AEs, there were more serious AEs with A+AVD compared [with] ABVD, 44% versus 28%. And there were no differences in deaths.

The A+AVD regimen can cause peripheral neuropathy. But if you look at complete resolution of peripheral neuropathy, you can see that 78% of patients treated with A+AVD had complete resolution and 83% of those on ABVD had complete resolution. Patients receiving ABVD also get neuropathy primarily because of vinblastine. Improvement in neuropathy also occurred in both groups; 17% of patients had improvement, not resolution, in the A+AVD arm versus 9% in the ABVD arm. The vast majority had resolution, but many had improvement as well.

However, for ongoing neuropathy that [was] grade 1 or 2, 25% of patients in the A+AVD arm and only 11% in the ABVD group experienced this. We have to be vigilant and monitor them throughout treatment so that it doesnt get too bad, so appropriate dose reductions can be made.

The bottom line here is most neuropathy is going to go away, but there will be patients where neuropathy can persist, and that can be an annoying thing, especially for a young person. For many in long-term follow-up, theyll experience improvement in neuropathy over time, which means things are getting better, but that doesnt mean its all resolved.

References:

1. NCCN Clinical Practice Guidelines in Oncology. Hodgkin lymphoma, version 2.2020. Accessed August 26, 2020. http://bit.ly/2YAIYha

2. Connors JM, Jurczak W, Straus DJ, et al. Brentuximab vedotin with chemotherapy for stage III or IV Hodgkins lymphoma. N Engl J Med. 2018;378(4):331-344. doi:10.1056/NEJMoa1708984

See the original post:
Ghosh Addresses Brentuximab Vedotin Use in Advanced Hodgkin Lymphoma - Targeted Oncology

The Daily Beast

Everyone knows that live television isnt easy. Anything can go wrongfrom a faulty connection, a verbal slip-up, or, as was the case on Tuesday mornings Fox & Friends, Rudy Giuliani bellowing insane conspiracy theories at the nation with no obvious way to stop him.Its always a risk to allow Giuliani to share his wildly unpredictable stream of consciousness live. The man who was named Time magazines Person of the Year for 2001 has long been reduced to sharing the latest Trumpist conspiracy theories on any cable news channel that has the budget to cover any possible subsequent defamation lawsuits.This time, his F&F hosts looked on with visible horror in their eyes as Giuliani shared his completely baseless belief that Joe Biden is suffering from dementia. If you have the time, its worth watching the clip at least three times so you can see each of the hosts panicking in their own unique way as the former New York City mayor rambles on and on.> On Fox & Friends, Rudy Giuliani says Joe Biden "has dementia. There's no doubt about it. I've talked to doctors. ... The president's quite right to say maybe he's taken adderall." The hosts get visibly uncomfortable. pic.twitter.com/2Ma7DKNBpS> > Bobby Lewis (@revrrlewis) September 29, 2020With a mischievous cackle, Giuliani began: The man [Biden] has dementia. Theres no doubt about it. Ive talked to doctors. Ive had them look at a hundred different tapes of his five years ago and today. Trying his very best to shut Giuliani down, host Steve Doocy interjected that Bidens team have said the Democrat has no serious medical problems.Giuliani then made an extraordinary noise at Doocy that can best be typed as Oowughawughawugh, before continuing: He cant recite the Pledge of Allegiance and hes fine? He was in the Senate for 160 years? I mean, he cant do the prologue to the... to the... con... to the... uh... Constitution of the United States or the Declaration of Independence, any of them.Getting louder and increasingly excited about his armchair diagnosis, Giuliani went on: He cant do NUMBERS. Wow, are the numbers screwed up. He actually displays symptoms that two gerontologists told me are classic symptoms of middle level dementia. Doocy and co-host Ainsley Earhardt both responded to that claim by softly saying: Right. The third host, Brian Kilmeade, can just be seen blinking rapidly.Fox News Lobotomizes Its Brain Room, Cuts Fact-Based JournalismNevertheless, Giuliani persisted. Thats when [Biden] does that I pledge allegiance to the United States... uh... uh... um... I think, hes done that twice, said the ex mayor. Thats a classic symptom in the DSM-V, its the fifth symptom, of dementia, hes got eight of the 10.Then, seemingly remembering that he was on the show to talk about tonights presidential debate, he went on: Look, that isnt the debate. He can get through it. I think the president is quite right to say maybe hes taken Adderall or some kind of attention deficit disorder thing.As Giuliani began pulling prescription medicine brands out of the air, Doocy had finally had enough and told him firmly: None of us are doctors, that is your opinion. Giuliani fought back, saying it was actually the opinion of some very professional-sounding doctors that he knows.But the game was up. Kilmeade, in his first verbal interjection of the entire exchange, said with exasperation: We can stay away from that. Earhardt then moved on to pick Giulianis brain on the Supreme Court.This particular line of attack is one that Giulianiwhose work as President Trumps lawyer and top dirt-digger on Hunter and Joe Biden kicked off a chain of events that got his client impeached last yearhas enthusiastically embraced as one of his primary functions now for Team Trump.Shortly before midnight on Monday night, Giuliani started texting The Daily Beast to say that Trump did great in recent White House debate prep (for which the president said on Sunday that Giuliani and former New Jersey governor Chris Christie took part), and to rail against Biden as a senile, broken down old crook whos supposedly suffering from dementia and needs ADD drugs to get through the Tuesday debate. The Trump attorney also claimed that someone had told him how stupid Biden was in law school.Giuliani also mentioned late Monday evening that hed be flying with Trump on Air Force One on Tuesday and would be at the Cleveland debate. Asked about what kinds of questions he peppered the president with during the prep, the former New York City mayor replied, It really doesnt work like that with him. Its much more of a discussion rather than a rehearsal. Plus you are dealing with a very smart, very alert human being not a senile old man.Read more at The Daily Beast.Get our top stories in your inbox every day. Sign up now!Daily Beast Membership: Beast Inside goes deeper on the stories that matter to you. Learn more.

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Global Diabetic Neuropathy Treatment Market by Business Development, Innovation and Top Companies Forecast 2020-2025 - seaview road

NEWARK, Del., Sept. 24, 2020 /PRNewswire/ --Neurophth Therapeutics, Inc., (hereinafter referred to as "Neurophth") today announced that its leading candidate, NR082 (rAAV2-ND4, NFS-01 project), was granted an orphan drug designation (ODD) by the U.S. FDA for the treatment of Leber's Hereditary Optic Neuropathy associated with ND4 mutation.

Leber's Hereditary Optic Neuropathy (LHON) is a maternally inherited mitochondrial disease, characterized by acute or subacute, painless vision loss or even loss simultaneously or sequentially, accompanied by central visual field defect and color vision impairment with poor prognosis. It was first reported by German scholar Leber in 1871. It affects about 1-9:100,000 people worldwide. LHON is one of the blinding diseases. The disease mainly occurs in young- and middle-aged men. Currently, there is no effective treatment for LHON. About 70% - 90% of LHON is caused by ND4 mutation of harboring a point mutation at nucleotide 11778 associated with a G-to-A transition. With the development of NR082, AAV-based gene therapy of LHON becomes possible.

"Due to the lack of effective treatment, the quality of life of LHON patients associated with ND4 mutation is very poor, and a huge unmet medical needs have not been fulfilled," said Dr. Alvin Luk, Chief Executive Officer at Neurophth. "NR082 is the first candidate drug developed by Neurophth. It uses recombinant adeno-associated virus serotype 2 to deliver the genetically modified ND4 gene (rAAV2-ND4). After a single intravitreal injection, the gene is translated and expressed in cells, which effectively supplements the function loss caused by endogenous mutation. Through this gene therapy, the electron transport function of mitochondrial respiratory chain was maintained, and the increase of ATP synthesis restored the normal function of mitochondria, which in turn improved the sensory function of the retinal ganglion cells and improved the visual acuity of LHON patients."

Luk added, "the significance of orphan drug designation is that regulators recognize the unmet medical needs of rare diseases like LHON. The recognition of NR082 will reduce the R&D investment to a certain extent and accelerate the progress of clinical trials and marketing registration. Furthermore, Neurophth is committed to fundamentally solve the causes and change the quality of life of patients through a single treatment of gene therapy."

Professor Bin Li, Founder, Chairman and Chief Scientific Officer at Neurophth, said: "NR082 has been granted as orphan drug by U.S. FDA, which further strengthens our focus on gene therapy for rare ophthalmic diseases, and develops more drugs for treatment of ocular genetic diseases, bringing hope to patients with ocular genetic diseases in the world".

*FDA grants orphan drug designation to drugs and biological products designed to safely and effectively treat, diagnose, or prevent rare diseases or conditions affecting less than 200,000 people in the US. According to the Orphan Drug Act of FDA, Orphan Drug Designation (ODD) provides opportunities for grant funding, fast approval channel, and some incentives, such as waiver of New Drug Application (NDA) fees, tax credits for clinical trial expenses and exemption for prescription drug users' fees as well as the products are entitled to a seven-year of market exclusivity and will not be affected by patents.

About NR082 (rAAV2-ND4; NFS-01 Project)

LHON disease is caused by mutations in mitochondrial DNA 11778, 14484 or 3460. ND4 gene of 11778 G>A mutation is the main pathological factor, which exists in 55-70% of European and American patients and 90% of Chinese patients. NR082 (NFS-01 project) is an innovative candidate drug for ophthalmic AAV-based gene therapy. It uses AAV2 vector to express human ND4 gene in the retinal ganglion cells to repair optic neuropathy caused by 11778 G>A mutation.

As early as 2011, Professor Bin Li's team started the world's first LHON gene therapy investigator-initiated trial (IIT) with this candidate drug. Nine subjects who participated in the clinical trial have been followed up for up to 8 years with no serious adverse reactions, and 5 of them have significant improvement in their vision. This result is the longest follow-up record of gene therapy in the world, which has already been published in the Scientific Report, EBioMedicine and Ophthalmology journals, and has fully proven the long-term safety, effectiveness, and durability of AAV gene therapy in clinical settings.

After the gratifying results of the first study, Professor Li's team conducted a more comprehensive IIT clinical study from 2017 to 2018, with 159 subjects (including 10 subjects from Argentina), which is the largest clinical trial in the entire gene therapy in the world. Among those, 143 of the patients has completed the 12-month follow-up and 56.6% showed a significant BCVA (best-corrected visual acuity improved by at least 0.3 LogMAR) improvement. No serious adverse reaction was found. In May 2020, at the 23rd online annual meeting of the American Society for Gene and Cell Therapy (ASGCT) and the online annual meeting of the Association for Research in Vision and Ophthalmology (ARVO), Neurophth presented these two clinical research data on the treatment of LHON with NR082 (NFS-01 project of rAAV2-ND4), demonstrating the international advanced level of this research in the field of gene therapy.

Following the positive results of these two IIT trials, Neurophth is actively preparing the China/U.S. IND (Investigational New Drug) applications, and plans to carry out the registration clinical Phase 1/2/3 registration trial to evaluate the safety, efficacy and durability of NR082.

About Neurophth

As a clinical-stage R & D company, Neurophth is committed to exploring and developing new therapies for global patients with ophthalmic diseases. With the help of the mature AAV ophthalmic gene therapy technology platform and the deep understanding of the ophthalmology field by the founding team for decades, Neurophth has established a rich, robust product pipeline, including more than 10 research projects for various ophthalmic diseases, such as dominant hereditary optic atrophy, optic nerve injury diseases, vascular retinopathy, etc., and gradually expanded from rare to common ophthalmic diseases. Additionally, the company is preparing to build a GMP commercial production platform for gene therapy drugs accordance with the international quality standards, and plans to build an ophthalmic gene therapy transformational excellence center, aiming to become a global leader in gene therapy in ophthalmology to benefit patients all over the world.

Prospect of Gene Therapy in Ophthalmology

Inherited retinal diseases (IRDs) have long been regarded as an ideal disease area for gene therapy, because most of the gene mutations leading to the disease have been identified (more than 200 gene defects are associated with the most common IRDS). The eye is, to some extent, an immune privilege. Clinical trials have shown that gene therapy using adeno-associated virus (AAV) or lentivirus (LV) vectors in the eye does not cause systemic side effects and does not cause significant immune responses. The most common IRDs were Retinitis Pigmentosa (RP), Achromatopsia color blindness (ACHM), Leber Hereditary Optic Neuropathy (LHON), Leber Congenital Amaurosis (LCA), Stargardt disease and X-linked Retinoschisis (XLRS).

To date, only one ophthalmic AAV gene therapy product has been approved in the world, namely the first AAV2 gene therapy voretigene neparvovec-rzyl (LUXTURNA; Spark Therapeutics) approved by FDA in December 2017 to treat IRD caused by RPE65 double allele mutation in adult or pediatric patients. The approval of LUXTURNAhas brought confidence and hope to the global ophthalmic gene therapy field. Public information disclosed that at least 20-30 kinds of gene therapy for ophthalmic diseases are in the research and development stage, and the international representative companies include Applied Genetic Technologies Corporation and Meira GTX, and new companies represented by Neurophth have also begun to enter the international stage of ophthalmic gene therapy.

References

Contact:Dr. Alvin LukAlvin.Luk@neurophth.com

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SOURCE Neurophth Therapeutics, Inc.

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Neurophth Therapeutics' Treatment of Leber's Hereditary Optic Neuropathy Gene Therapy NR082 was Granted Orphan Drug Designation by US FDA - BioSpace