StemCell Therapy

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Some of the Major Highlights of TOC covers:

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Cardiac Autonomic Neuropathy Treatment Market Is Expected To Experience An Impressive CAGR Growth Of XX% Through 2017 2025 - TechnoWeekly

INDIANAPOLIS and CAMBRIDGE, Mass., Oct. 15, 2020 /PRNewswire/ --Eli Lilly and Company (NYSE: LLY) today announced a definitive agreement to acquire Disarm Therapeutics, a privately-held biotechnology company creating a new class of disease-modifying therapeutics for patients with axonal degeneration. Disarm has discovered novel, potent SARM1 inhibitors and is advancing them in preclinical development, with the goal of delivering breakthrough treatments to patients with peripheral neuropathy and other neurological diseases such as amyotrophic lateral sclerosis (ALS) and multiple sclerosis.

Axonal degeneration is a common, yet unaddressed, pathology in a broad range of neurological diseases and is known to cause severe sensory, motor, and cognitive symptoms. Disarm's scientific founders, Dr. Jeffrey Milbrandt and Dr. Aaron DiAntonio of Washington University School of Medicine in St Louis, discovered that the SARM1 protein is a central driver of axonal degeneration. Disarm's SARM1 inhibitors are designed to directly prevent the loss of axons.

Under the terms of the agreement, Lilly will acquire Disarm for an upfront payment of $135.0 million. Disarm equityholders may be eligible for up to $1.225 billion in additional future payments for potential development, regulatory and commercial milestones should Lilly successfully develop and commercialize new medicines resulting from the acquisition.

"Lilly continues to seek medicines to treat the debilitating pain and loss of function associated with nerve damage," said Mark Mintun, M.D., vice president of pain and neurodegeneration research at Lilly. "The scientific team at Disarm discovered an important and highly promising approach to combat axonal degeneration. We will move quickly to develop their SARM1 inhibitors into potential medicines for peripheral neuropathy and neurological diseases, such as ALS and multiple sclerosis."

"Disarm's innovative approach to treating axonal degeneration holds tremendous promise for addressing a wide spectrum of neurological diseases, and we have made significant strides toward enabling potentially transformative therapies," said Alvin Shih, M.D., Chief Executive Officer of Disarm. "Lilly is ideally suited to advance this exciting new approach to treating axonal degeneration, and we look forward to seeing patients benefit from the work that Disarm initiated." Disarm was founded by Atlas Venture, Drs. Milbrandt and DiAntonio of Washington University School of Medicine in St. Louis, and Atlas Entrepreneurs-in-Residence Dr. Rajesh Devraj and Dr. Raul Krauss. Lightstone Ventures and AbbVie Ventures co-invested with Atlas to support the foundational work at Disarm.

This transaction will be reflected in Lilly's reported results and financial guidance according to Generally Accepted Accounting Principles (GAAP). There will be no change to Lilly's 2020 non-GAAP earnings per share guidance as a result of this transaction.

Aquilo Partners, L.P. acted as financial advisor and WilmerHale LLP as legal advisor to Disarm on this transaction.

About Disarm TherapeuticsDisarm Therapeutics is a biotechnology company that is creating a new class of disease-modifying therapeutics for patients with axonal degeneration, a central driver of neurological disability and disease progression. By inhibiting the SARM1 protein, identified by the company's scientific founders as the central driver of axonal degeneration, these therapeutics may prevent the loss of axons in chronic and acute diseases of the central, ocular, and peripheral nervous systems. For a broad range of diseases including multiple sclerosis, amyotrophic lateral sclerosis, glaucoma, and peripheral neuropathies, the therapeutic goal is to prevent further degeneration, stabilize disease, and allow for functional recovery.

AboutEli Lilly and CompanyLilly is a global healthcare leader that unites caring with discovery to create medicines that make life better for people around the world. We were founded more than a century ago by a man committed to creating high-quality medicines that meet real needs, and today we remain true to that mission in all our work. Across the globe, Lilly employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to communities through philanthropy and volunteerism. To learn more about Lilly, please visit us at http://www.lilly.com. C-LLY

Lilly Cautionary Statement Regarding Forward-Looking StatementsThis press release contains forward-looking statements (as that term is defined in the Private Securities Litigation Reform Act of 1995) about the benefits of Lilly's acquisition of Disarm Therapeutics ("Disarm"), and reflects Lilly's current beliefs. However, as with any such undertaking, there are substantial risks and uncertainties in implementing the transactionand in the process of drug development and commercialization. Among other things, there can be no guarantee that the transaction will be completed in the anticipated timeframe, or at all, or that the conditions required to complete the transaction will be met, that Lilly will realize the expected benefits of the acquisition, or that the acquisition will yield commercially successful products. For a further discussion of these and other risks and uncertainties that could cause actual results to differ from Lilly's expectations, please see Lilly's most recent Forms 10-K and 10-Q filed with the U.S. Securities and Exchange Commission. Lilly undertakes no duty to update forward-looking statements.

Refer to:Mark Taylor; [emailprotected]; (317) 276-5795 (Lilly Media)Kevin Hern; [emailprotected];(317) 277-1838 (Lilly Investors)Stephanie Simon; [emailprotected]; (617) 581-9333 (Disarm Media)

SOURCE Eli Lilly and Company

lilly.com

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Lilly Announces Agreement to Acquire Disarm Therapeutics - PRNewswire

Several late-phase results were shared during the European Society of Medical Oncology (ESMO) Virtual Congress in gynecologic malignancies, but the data presented generated excitement about the number of novel options for patients after initial treatment.

Updated findings in ovarian cancer demonstrated continued benefit for PARP inhibition as maintenance therapies following frontline treatment in advanced ovarian cancer in the phase 3 SOLO-1 trial (NCT01844986) using the PARP inhibitor olaparib (Lynparza) and in the phase 2 PRIMA/ENGOT-OV26/GOG-3012 ([PRIMA], NCT02655016), which utilized the PARP inhibitor niraparib (Zejula).

Enthusiasm also surrounded a potential new approach in cervical cancer from the phase 2 innovaTV 204/GOG-3023/ENGOT-cx6 study ([innovaTV], NCT03438396), which explored treatment with the investigational antibody-drug conjugate tisotumab vedotin.

The longest duration of follow-up for any PARP inhibitor in the previously untreated advanced ovarian cancer setting was performed in the phase 3, randomized, double-blind, placebo-controlled, multicenter SOLO-1 trial, in which olaparib maintenance was given to patients with BRCA mutations. The 5-year follow-up results were presented at ESMO by Susan Banerjee, MD, PhD, FRCP, consultant medical oncologist and research lead for the Gynecology Unit at The Royal Marsden.1

The updated analysis after 5 years of follow-up shows that the benefit of olaparib continues substantially beyond the end of treatment, Banerjee told Targeted Oncology in an interview.

Out of the 391 patients assessed, 260 received olaparib maintenance and 131 received placebo for up to 2 years or until progressive disease (PD). Olaparib maintenance first demonstrated an improvement in progression-free survival (PFS) in the primary analysis with the median PFS not yet reached in the olaparib arm at this timepoint compared with 13.8 months in the placebo arm (HR, 0.30; 95% CI, 0.23-0.41).

The median follow-up for the updated analysis was 4.8 years in the olaparib arm compared with 5.0 years in the placebo arm. The results showed PFS events in 45% of the olaparib-treated population versus 76% of the placebo population. The median PFS observed with olaparib maintenance was 56.0 months compared with 13.8 months in the placebo arm (HR, 0.33; 95% CI, 0.25-0.43).

These are very encouraging results that will help us explain the potential benefits of maintenance olaparib in patients with BRCA mutations, said Banerjee.

A new analysis of the phase 3 randomized, double-blind, placebo-controlled, multicenter PRIMA trial presented during ESMO by GiorgioValabrega, MD, investigated the potential difference in efficacy and safety by age of niraparib maintenance after chemotherapy in patients with advanced ovarian cancer.

The key findings of our trial were that there is no difference in terms of safety and efficacy by adding niraparib to chemotherapy. Also, the [adverse events] that were observed in patients above 65 and 75 [years of age] in comparison to younger patients are not different, Valabrega, associate professor, University of Torino School of Medicine, told Targeted Oncology in an interview.

The subanalysis included 444 patients from the original PRIMA study who were 65 years of age or younger. Of the patients included in this analysis, 297 received niraparib and 147 received placebo.2

A second cohort from the analysis included 289 patients aged 65 or older. Among this group, 76 patients were 75 years or older. One hundred ninety of the patients received niraparib maintenance while 99 received placebo in the younger cohort and of those 75 years or older, 54 patients received niraparib and 22 received placebo.

Demonstrating consistency with the primary analysis which showed a median PFS on 13.8 months with niraparib compared with 8.2 months in the placebo arm, niraparib maintenance prolonged PFS compared with placebo in this subanalysis. In the patients under the age of 65, the median PFS was 13.9 months with niraparib versus 8.2 months with placebo (HR, 0.61; 95% CI, 0.47-0.81). Patients aged 65 or older had a median PFS of 13.7 months with niraparib versus 8.1 months with placebo (HR, 0.53; 95% CI, 0.39-0.74). In the 75 years of age or below group, niraparib led to a median PFS of 13.8 months compared with placebo, which had a median PFS of 8.2 months (HR, 0.62; 95% CI, 0.50-0.77). Finally, in patients aged 75 of older, the median PFS was 13.8 months with niraparib versus 5.6 months with placebo (HR, 0.37; 95% CI, 0.17-0.81).

Both ages groups were similar in terms of the number percentage of treatment-emergent adverse events (TEAEs) observed. The most common treatment-emergent TEAEs were anemia, leukopenia and hypertension. Notably, patients aged 65 years or older experienced a small increase in thrombocytopenia during treatment as did those aged 75 years of age or older. The rates of 3 TEAEs were also similar between the age groups.

Results from the single-arm, multicenter, international phase 2 study innovaTV were presented during ESMO by Robert Coleman, MD, FACOG, FACS, chief scientific officer of The US Oncology Network. The result of the study was that treatment with tisotumab vedotin led to antitumor activity in patients with previously treated recurrent or metastatic cervical cancer.3

We basically confirmed the responses that we saw in the first-in-human phase 1 and 2 study with a 24% response rate, Coleman told Targeted Oncology.

Importantly, 7% of those patients had complete response, which, for those of who have treated this disease, these are not common findings, he added.

As Coleman shared, the objective response rate observed in the trial was 24% (95% CI, 15.9%-33.3%), with complete responses in 7% of the population, partial respondes in 17%, and stable disease in 49%. In terms of PD, 24% of patients progressed on treatment. The median duration of response observed with tisotumab vedotin was 8.3 months (95% CI, 4.2 to not reached). Notably, the treatment also led to a decrease in target lesion size in 79% of the patients who received tisotumab vedotin when compared with their baseline measurements.

Among the confirmed responders, the median time to response was 1.4 months (range, 1.1-5.1). It was also noted during Colemans ESMO presentation that responses were seen across the subgroup populations explored, regardless of tumor histology, lines of prior therapy, or responses to prior treatment.

The median PFS achieved with tisotumab vedotin was 4.2 months (95% CI, 3.0-4.4). At 6 months, the PFS rate was 30% (95% CI, 20.8%-40.1%). The median overall survival with the agent was 12.1 months (95% CI, 9.6-13.9) and the 6-month OS rate was 79% (95% CI, 69.3%-85.6%).

Treatment-related AEs (TRAEs) occurred in greater than 10% of the study population. The majority of the (TRAEs) observed in this study were grade 1 and 2 in severity. The most TRAEs of any grade were alopecia (38%), epistaxis (30%), nausea (27%), conjunctivitis (26%), and fatigue (24%). One patient in the died as a results of treatment-related septic shock.

Ocular, bleeding, and neuropathy TRAEs were also assessed in the study and bleeding TRAES were most prevalent, with grade 1 events having observed in 34% of patients. Ocular TRAEs were the second most prevalent with grade 1 events having occurred in 25% of patients. Finally, grade 1 peripheral neuropathy occurred in 17% of patients.

Data from this study led to the conclusion that tisotumab vedotin is a potential new treatment option for patients with previously treated recurrent of metastatic cervical cancer.

References:

1. Banerjee S, Moore KN, Colombo N, et al. Maintenance olaparib for patients (pts) with newly diagnosed, advanced ovarian cancer (OC) and a BRCA mutation (BRCAm): 5-year (y) follow-up (f/u) from SOLO1. Presented at: 2020 ESMO Virtual Congress; September 19-21, 2020. Virtual. Abstract 811M0.

2. Valabrega G, Pothuri B, Oaknin A, et al. Efficacy and safety of niraparib in older patients (pts) with advanced ovarian cancer (OC): Results from the PRIMA/ENGOT-OV26/GOG-3012 trial. Presented at: 2020 ESMO Virtual Congress; September 19-21, 2020; Virtual. Abstract 819P.

3. Coleman RL, Larusso D, Gennigens C, et al. Tisotumab vedotin in previously treated recurrent or metastatic cervical cancer: results from the phase 2 innovaTV 204/GOG-3023/ENGOT-cx6 study. Presented at: 2020 ESMO Virtual Congress; September 19-21, 2020; Virtual. Abstract LBA32.

Original post:
Updated Findings Show Continued Benefit of PARP in Ovarian Cancer, New Agent on the Scene in Cervical Cancer - Targeted Oncology

When it comes to exercise for arthritis, even simple moves like stretching can help ease joint pain and stiffness.

Image Credit: kali9/E+/GettyImages

If you have arthritis, going for a jog may seem like it would do your joints more harm than good. But as counterintuitive as it seems, physical activity may be just what the doctor ordered.

About 54 million people in the U.S. have been diagnosed with arthritis, an inflammatory condition that causes joint pain and swelling.

These symptoms can also prevent people from exercising: Almost 24 percent of people with arthritis don't do any physical activity (compared to about 18 percent of those without the condition), according to the Centers for Disease Control and Prevention (CDC).

"In general, people with arthritis tend to want to take it easy or not exercise as much," Brian Andonian, MD, a rheumatologist and assistant professor of medicine at Duke University School of Medicine, tells LIVESTRONG.com. "But exercise, done right, is probably one of the most beneficial things they can do to help their joints."

Osteoarthritis, the most common type of arthritis in the U.S., occurs when the cartilage surrounding the ends of bones (such as those of the knees and hands) break down which is partly why it's known as "wear and tear" arthritis. But in some ways, that definition can be misleading.

"The 'wear and tear' component is really much more specific," says Joseph Garry, MD, a visiting professor of clinical family medicine at the University of Illinois College of Medicine Rockford. "It's not so much moving or exercising."

Rather, he explains, osteoarthritis can be caused by overloading the joint, by being overweight, maybe, or by carrying lots of heavy objects at work. Joint injuries, such as those sustained by playing a sport, may also increase the risk for osteoarthritis, he says.

Exercise, however, can help ease pain from osteoarthritis as well as from other inflammatory types of arthritis, including rheumatoid and psoriatic arthritis, says Dr. Andonian.

Ready to get started? Here's a closer look at why exercise is so beneficial for people with arthritis, and how to start working out safely.

Why Exercise Is Good for Arthritis

Exercise can reduce pain, improve joint function and boost the quality of life of people with arthritis, according to the CDC.

One early investigation into exercise and arthritis, published January 2008 in the journal Arthritis & Rheumatism, found that people with arthritis who participated in an exercise program felt less pain and fatigue at the end of eight weeks than those who didn't work out. Plus, they continued to feel less pain and fatigue six months later.

Newer research has confirmed those findings, concluding that even short periods of activity can help prevent joint pain from worsening. In a study published May 2019 in the American Journal of Preventive Medicine, people with joint pain who performed one hour of moderate-to-vigorous activity a week were less likely to develop a disability after four years as those who weren't as active.

"Any exercise for somebody with arthritis who's sedentary is going to be helpful. Every little bit adds up, even a few minutes here and there."

Exercise can help ease joint pain in a few ways, says Dr. Andonian. For starters, he says, physical activity can strengthen the muscles that surround the joint, which helps take some of the pressure off the joint itself. It also helps you sleep better, which can also help ease pain.

Another way exercise can help ease arthritis symptoms is by lowering the levels of inflammation in the body, which is a characteristic of arthritis, he says.

"I think of exercise as being an anti-inflammatory treatment," says Dr. Andonian. "We know that exercise has pretty powerful ways of [regulating] the way the immune system works."

Specifically, he explains, fat is more pro-inflammatory than lean muscle mass, which tends to be more anti-inflammatory and beneficial for arthritis.

The Best Types of Exercise for Arthritis

Yoga is a great way to improve your balance and range of motion when you have arthritis.

Image Credit: Ridofranz/iStock/GettyImages

Because both aerobic exercise and strength training improve body composition, doing either one and ideally both can help improve arthritis symptoms, Dr. Andonian says.

Other types of activity that you may want to try include range-of-motion and body awareness exercises, according to the American College of Rheumatology.

Here are some examples of these four main types of exercise, plus good options for people with arthritis:

3. Range-of-Motion Exercises

4. Body Awareness Workouts

If you're just starting an exercise program, one of the best things you can do is commit to an activity that you like to do, and one that's also compatible with your schedule and lifestyle.

"Keeping up a program in the long-term has got to be enjoyable," Dr. Andonian says.

The CDC recommends adults get at least 150 minutes of moderate-intensity aerobic exercise or 75 minutes of vigorous exercise each week, but if you haven't been exercising very much (if at all), try working up to that goal slowly, over time, says Dr. Andonian.

"Any exercise for somebody with arthritis who's sedentary is going to be helpful," he says. "Every little bit adds up, even a few minutes here and there."

Are There Any Risks to Exercising With Arthritis?

Before you start a new exercise program, it's a good idea to let your doctor know what you're doing, says Dr. Andonian. Your provider may be able to refer you to another health care professional, like a physical therapist, who can design a workout plan for you and even help coach you through the movements.

After you start exercising, you'll probably feel some stiffness or swelling, possibly for six to eight weeks, according to the CDC. But that's OK.

"A little bit of soreness isn't necessarily a bad thing, especially if you're starting to get some gains over time," Dr. Andonian says.

That said, you may want to modify certain exercises to make them more comfortable for you, he says. For example, if you have knee osteoarthritis, you can try starting a walking program, but avoid climbing a lot of hills. Or, if you want to try cycling but have arthritis in your spine or hip, he recommends sitting on a bike in a reclined position, which can be more comfortable.

Even if you're having a flare-up of arthritis, it's still a good idea to try to do some exercise.

"A lot of people just completely stop all activities," he says. "I recommend that people try to stay active as much as they can within their comfort zone, even just doing light activities like range-of-motion type exercises."

If you happen to feel any sharp, stabbing and constant pain, pain that causes you to limp or pain in your joints that are red or feel "hot," the CDC recommends calling your doctor.

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The 4 Best Types of Exercise to Ease Arthritis Pain and Stiffness - LIVESTRONG.COM

Arthritis leads to inflammation and pain in joints. It reduces mobility and make it difficult to perform day to day activities. Here are some foods that you should avoid if suffering from arthritis.

Arthritis diet should include foods anti-inflammatory foods

Arthritis is a condition that affects the joints of an individual. It leads to pain, stiffness and inflammation in the joints. The symptoms of arthritis worsen with age. There are several types of arthritis that can affect a person. Pain, stiffness, swelling, reduced range of motion and redness near the joints are some typical symptoms of this condition. Arthritis diet includes foods that can help ease inflammation and joint pain. It is usually suggested to add anti-inflammatory foods to an arthritis diet. Therefore, people with arthritis are often advised to avoid foods that can trigger inflammation. Here's a list of foods that people with arthritis should be avoiding.

Consumption of sugar in excess can result in inflammation as per studies. It can also lead to weight gain which can make it hard to manage this condition. Sugar is usually hidden in several foods and drinks. You should also avoid foods with added sugar.

Consuming too much sugar can contribute to weight gainPhoto Credit: iStock

Ultra-processed foods may also contain inflammatory ingredients that can worsen the symptoms of arthritis. Highly processed foods are generally high in salt and sugar which are harmful to your health when consumed in excess.

Also read:Arthritis Diet: 5 Anti-Inflammatory Foods That Should Be A Part Of Your Diet

Studies have shown that drinking too much alcohol can increase the severity of gout which is a type of arthritis. It can also increase inflammation. Too much alcohol consumption is also linked with several health conditions.

Also read:These Remedies Can Help Relieve Arthritis Pain Naturally

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Studies have also highlighted that consuming processed meat regularly may demonstrate high levels of inflammation.

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.

DoctorNDTV is the one stop site for all your health needs providing the most credible health information, health news and tips with expert advice on healthy living, diet plans, informative videos etc. You can get the most relevant and accurate info you need about health problems like diabetes, cancer, pregnancy, HIV and AIDS, weight loss and many other lifestyle diseases. We have a panel of over 350 experts who help us develop content by giving their valuable inputs and bringing to us the latest in the world of healthcare.

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Arthritis Diet: Avoid These Foods And Drinks To Fight Inflammation Effectively - Doctor NDTV

Working in the medical field for over 30 years helped me navigate health care appointments for my rheumatoid arthritis. I'm not afraid to ask if I need a test, and if I think that something needs to be looked at, I'm not shy: I ask. The patient has a right to do that, and I have a very good relationship with my health care team.

After years of trying different medications that I couldnt tolerate for long periods or that didn't work for me, including methotrexate and NSAIDs, I started taking a biologic in 2001, 10 years after my diagnosis. Im still on it. For me, its been a life changer. I think its the reason Im still able to work full-time, which in turn keeps me going.

What also helped was finding a community who understood what I was going through. In 1991, the only way I could see how people handled living with rheumatoid arthritis was by watching VHS tapes from the library. I didnt know anyone else with arthritis when I was diagnosed, or anyone else on my treatment. I wanted to talk to somebody else and see how it was going for them, and share my great experience with people.

For years, it felt like no one understood. If I tried to talk to someone about the pain and the obstacles I was facing, people accused me of being negative. I needed to find people who were uplifting.

In 2002, I discovered CreakyJoints, a community for people with arthritis. Meeting other people online in the chat room and later on the Facebook page was really helpful, and I started reading the monthly newsletter. Although Im naturally a shy person, I wanted to get more involved. I edited the poetry section of the newsletter for three years, helped put together a book in 2017, and became one of the first members of the patients council. We meet monthly and work on pamphlets to help raise awareness, especially about the mental health side of living with arthritis. I really want people to know that if you're having a hard time coping, it's okay to find somebody to talk to. You don't have to go this alone. There are people out there just like you. And when you reach out for help, youre not only helping yourself, youre helping others as well.

As hard as rheumatoid arthritis can be, Ive always had hope. In 2020, I started noticing that I was feeling better. Things like getting dressed, which could be absolute agony, were easier. I started seeing a new rheumatologist in February, and after a check-up in August, I found out I was already in remission. I thought, I'm in remission? I was shockedit was awesome!

Being in remission from rheumatoid arthritis is almost like being given a gift. I was briefly in remission 10 years ago, and even though it only lasted a couple of months, I always said it could happen again: I never gave up hope. Im hoping it will last longer this time.

Im very aware that I still live with rheumatoid arthritis. It hasn't suddenly gone away, it's just that things are quiet right now. I still experience fatigue and I still live with pain. I have joint deformity from before I started taking the treatment Im on, and that will never be fixed. But I havent had very bad days since remission. I still have to be vigilant and keep taking my medication, and keep doing all the things Ive been doing to stay healthy. Exercise is very important; I walk half a mile to and from work most weekdays, even in the winter! I also know when to rest, especially since Im more vulnerable to infections on the medication.

Attitude is so important too. When you have rheumatoid arthritis, not every day is going to be great. But I find that if you can bring humor, even when you're in pain, it can at least get your mind off it for a little while. And dont ever give up hope. I trust scientists, and just look at the drugs that are out there now, and the ones that are still being developed. Ive lived with the disease for a long time, and I want people to know that Im proof that remission can happenand its great.

This interview has been edited and condensed for clarity.

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Rheumatoid Arthritis Remission: This Is What It Really Feels Like - Self

Background and objectives: To investigate the serum procalcitonin (PCT) levels among patients with rheumatoid arthritis (RA) without active infection compared with healthy controls and to understand the relationship of PCT with RA disease activity, and treatment received by patients.

Materials and Methods: Patients aged 20 years and above with clinician-confirmed diagnosis of RA and healthy volunteers were included during regular outpatient visits, and those with active infection symptoms and signs were excluded. RA disease activity was measured using the Disease Activity Score-28 for Rheumatoid Arthritis with erythrocyte sedimentation rate (DAS28-ESR). Medications received by the patients were also recorded.

Results: A total of 623 patients with RA and 87 healthy subjects were recruited in this study. The mean PCT were significantly higher in patients with RA (6.90 11.81 10-3ng/mL) compared with healthy controls (1.70 6.12 10-3ng/mL) (p< 0.001) and the difference remained statistically significant after adjusting for age and sex. In addition, multiple linear regression analysis showed that a lower rank-transformed PCT serum level was significantly correlated with the use of biologics (p= 0.017) and a high DAS28-ESR score (p = 0.028) in patients with RA.

Conclusion: Patients with RA have a significantly higher serum PCT levels compared with healthy controls. The use of biologics and an active RA disease activity were associated with a lower level of PCT in patients with RA. Further investigation is required to determine the optimal cutoff value of PCT among patients with RA and its association with disease activity and biologic usage.

Keywords:disease activity; disease activity index; infection; procalcitonin; rheumatoid arthritis.

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Modestly Elevated Serum Procalcitonin Levels in Patients with Rheumatoid Arthritis Free of Active Infection - DocWire News

Introduction:Enthesitis is a core outcome domain assessed in psoriatic arthritis (PsA) clinical trials. Limited evidence describes the impact of enthesitis on patient-reported outcomes (PROs) and physician satisfaction with current treatment options. The objective of this analysis is to characterize the impact of enthesitis on PROs and physician satisfaction with currently available treatment in clinical practice settings.

Methods:Cross-sectional survey of rheumatologists, dermatologists, and their consulting patients with PsA in Australia, Canada, European Union (EU5), and the USA conducted in 2018. Physicians assessed current presence and severity of enthesitis, overall disease severity, other symptoms experienced, and their satisfaction with the current treatment. PsA participant self-reported data included current pain level, EQ5D, Psoriatic Arthritis Impact of Disease (PsAID12), Health Assessment Questionnaire Disability Index (HAQ-DI), and Work Productivity and Activity Impairment Index (WPAI-SHP). Bivariate descriptive analyses were conducted to describe features and outcomes in participants with and without enthesitis.

Results:Rheumatologists (454) and dermatologists (238) provided information for 3157 participants with PsA. Mean participant age was 49.2 years, and 45.9% were female. Enthesitis was present currently in 6.5% (205) of participants with PsA. Those with enthesitis had worse overall disease severity compared to those without enthesitis (12.2% vs 2.2% severe) and had more extraarticular manifestations, including nail psoriasis, dactylitis, and sacroiliitis. Enthesitis was associated with more pain, worse quality of life (QoL), increased disability, and a negative impact on work. Participants with enthesitis had higher NSAIDs and opioid pain medication use but similar biologic use. Physicians were significantly less satisfied with current PsA treatment in participants with enthesitis versus without enthesitis.

Conclusions:Participants with psoriatic arthritis with enthesitis experienced significantly higher disease burden than those without enthesitis but were not more likely to receive advanced therapies. Physicians were significantly more dissatisfied with treatment in patients with enthesitis than in those without it.

Keywords:PROs; Patient-reported outcome; Psoriatic arthritis; Real-world evidence; Satisfaction.

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Impact of Enthesitis on Psoriatic Arthritis Patient-Reported Outcomes and Physician Satisfaction with Treatment: Data from a Multinational Patient and...

Objective:To assess MR features following MPFL reconstruction and determine their influence on post-operative pain, progressive arthritis, or graft failure.

Materials and methods:Retrospective study on 38 patients with MPFL reconstruction and a post-operative MRI between January 2010 and June 2019. Two radiologists assessed MPFL graft signal, graft thickness, femoral screw, femoral tunnel widening, and patellofemoral cartilage damage. The third performed patellofemoral instability measurements. All three assessed femoral tunnel position with final result determined by majority consensus. Imaging findings were evaluated in the setting of post-operative pain, patellofemoral arthritis, and MPFL graft failure including need for MPFL revision. Statistics included chi-square, Fishers exact test, t test, and kappa.

Results:Mean graft thickness was 6.0 1.8 mm; 24% of the grafts were diffusely hypointense. Mean femoral tunnel widening was 2.5 1.8 mm; 34% of the femoral screws were broken or extruded. Fifty-two percent of the patients had no interval cartilage change. Non-anatomic femoral tunnels were found in 66% of patients, including in all 9 patients requiring revision MPFL reconstruction (p = 0.013). Revised MPFL grafts had more abnormal femoral screws compared to those that did not (67% vs. 24%) (p = 0.019). Other MR features did not significantly influence the evaluated outcomes.

Conclusion:The need for revision MPFL reconstruction occurs more frequently when there is a non-anatomic femoral tunnel and broken or extruded femoral screws. The appearance of the MPFL graft itself is not an influencing factor for post-operative pain, progression of patellofemoral arthritis, or graft failure.

Keywords:Graft failure; MPFL reconstruction; MRI; Medial patellofemoral ligament; Post-operative knee.

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MRI following medial patellofemoral ligament reconstruction: assessment of imaging features found with post-operative pain, arthritis, and graft...

Arthritis means sore joints and often lots of painkillers to keep the aches at bay. But there could be alternatives to popping prescription pills every day, according to experts.

Exercise, weight loss and supplements, such as vitamin D and rosehip, could help manage the often agonising symptoms of joint health, it is claimed. Dr Alastair Dickson, a GP with an interest in arthritis, said joint problems are common.

They can be caused by lots of things and can be short-term pain or more long term, he said. Acute pain is often caused by knocks, sprains and other injuries. Typically, this pain will get better over a number of days or weeks.

Persistent joint pain often results from more chronic processes related to trauma and wear and tear, such as osteoarthritis, and inflammatory arthritis.

Osteoarthritis, Dr Dickson explains, is the response of your body trying to heal your joints and can have a significant impact on the lives of sufferers. The condition is most common in the over 40s, and in people who have suffered more trauma in their joints. It can affect any joint, but the most common are hips, knees, ankles, hands, fingers and neck.

Joint pain is different for each patient, Dr Dickson said.

Commonly osteoarthritis in the large joints (such as your knees and hips) affects your mobility whilst osteoarthritis of your shoulders, hands and fingers can affect your ability to lift and open and close things making everyday tasks such as dressing difficult.

Neck osteoarthritis can make movement such as looking up awkward and painful, he said.

In Scotland it is estimated that 16.6% of people aged over 45 years suffer with knee osteoarthritis and 10.1% have hip osteoarthritis.

The symptoms of osteoarthritis, especially pain, tend to develop slowly and build-up in severity over time, typically years, Dr Dickson explained. If you have pain from osteoarthritis the symptoms are individual to you. Treating everyone in the same way doesnt work.

When it comes to treatment, non-weight bearing exercise and weight loss are considered crucial. And painkillers are often prescribed but Dr Dickson says alternatives, such as physiotherapy, cognitive behavioural therapy and evidence-based supplements, can help reduce this long-term reliance on pain relief. Over recent years, evidence has been accumulating that overuse of painkillers is problematic and doesnt necessarily cure the pain, he said.

Paracetamol is often insufficient for the pain on its own. To complicate matters further drugs that work for one person dont necessarily work for someone else. There is currently a very large change in practice being suggested with the National Institute for Health and Care Excellence (NICE) draft guidance advising most painkillers for chronic pain should not be used long term as they are ineffective.

The answer, Dr Dickson says, could be to look at the causes of pain and consider supplements where there is good evidence that they are safe and clinically effective. Unfortunately many supplements, such as glucosamine or chondroitin products, rubefacient creams (deep heat creams) are currently not considered to be either clinically or cost-effective following reviews by the NHS.

However, increasing vitamin D has been shown to reduce muscular pain and evidence suggests rosehip may be effective in relieving some symptoms. Dr Dickson, who advises a company who supports GOPO, a rosehip-containing medication, explained: A summary analysis of three clinical trials found that rosehip-containing medications are clinically effective in reducing pain. Studies have found that some rosehip compounds appear to have anti-inflammatory properties and potential benefits to cartilage but there have been no clinical trials to confirm this in patients.

Some patients use rosehip as an alternative to paracetamol. Its not available on the NHS but can be bought over the counter from a chemist. NICE is currently reviewing its osteoarthritis guidance and there should be updated guidance next year. Hopefully NICE will include rosehip compounds in its updated analysis.

He added: I use painkillers but over recent years the evidence has changed for why and how we should be using them: I now increasingly advise that they are to help you to start to mobilise by reducing not curing your pain.

We use the lowest dose possible for the shortest time.

This doesnt mean never taking them but rather educating the patient so they become the expert and, armed with the information, they can become more in charge of how best to manage their pain and when to use painkillers.

Many over-the-counter supplements are thought to be helpful for arthritis sufferers. Here are some you could try:

Glucosamine

Helps keep the cartilage in joints healthy and may have an anti-inflammatory effect. Natural glucosamine levels drop as people age.

Chondroitin sulfate

Often used with glucosamine as an osteoarthritis treatment, researchers found that chondroitin appeared to reduce pain, increase joint mobility, and decrease the need for painkillers.

Omega 3 fatty acids

Found in fish oil, Omega 3 fatty acids encourage the body to produce chemicals that help control inflammation. May help ease stiffness for rheumatoid arthritis patients.

Curcumin

Active ingredient of turmeric, it has anti-inflammatory properties and provides relief for people with osteoarthritis of the knee.

Green tea

Packed with polyphenols, antioxidants believed to reduce inflammation and slow cartilage destruction.

Vitamin D

Important for keeping bones strong and preventing injuries from falls. Research shows that people with low levels of vitamin D may have more joint pain.

Ginger

May be beneficial in managing the inflammation and pain of arthritis, due to anti-inflammatory effects.

Rosehip

Contains polyphenols and anthocyanins, which are believed to ease joint inflammation and prevent damage.

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Health: The alternative ways to ease joint pain and arthritis - The Sunday Post

Objective:To assess satisfaction with the effectiveness and tolerability of treatments in patients with rheumatoid arthritis (RA).

Methods:Patients from the RABBIT register, starting a biological (b) or targeted synthetic (ts) disease-modifying antirheumatic drug (DMARD), or a conventional synthetic (cs)DMARD treatment after 1 csDMARD failure, were included. Treatment satisfaction was measured after 1 year of treatment in four categories and binarised for analysis. Logistic regression models were performed to calculate ORs for factors associated with treatment satisfaction.

Results:Data of 10 646 patients (74% women, mean 58 years) were analysed. At baseline, 55% of the patients were satisfied with the efficacy and 68% with the tolerability of their previously given treatments. After 1 year, 85% of the patients were satisfied with treatment effectiveness and 90% with tolerability. Baseline satisfaction (OR 2.98, 95% CI 2.58 to 3.44), seropositivity (OR 1.36, 95% CI 1.17 to 1.57), reduction of DAS28 (OR 1.38, 95% CI 1.31 to 1.46) and pain (OR 1.26, 95% CI 1.22 to 1.31), and the improvement of physical capacity (OR 1.22, 95% CI 1.17 to 1.29) were positively associated with treatment satisfaction at follow-up while glucocorticoids (GCs) >5 mg/day, depression, fibromyalgia, obesity, prior bDMARDs and therapy changes were negatively associated. The impact of GC on satisfaction was dose-dependent, becoming strongest for GC >15 mg (OR 0.24, 95% CI 0.16 to 0.34). A 5 mg/day reduction within 12 months was positively associated with satisfaction regarding efficacy (OR 1.19, 95% CI 1.11 to 1.27) and tolerability (OR 1.11, 95% CI 1.03 to 1.21).

Conclusion:Most patients were satisfied with their treatments effectiveness and tolerability after 1 year of treatment. Tapering GCs was positively associated with the improvement of patients satisfaction.

Keywords:Arthritis; Biological Therapy; Patient Reported Outcome Measures; Rheumatoid.

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Factors associated with treatment satisfaction in patients with rheumatoid arthritis: data from the biological register RABBIT - DocWire News

SIMPONI ARIA (golimumab) is a fully human monoclonal antibody used for the treatment of active polyarticular juvenile idiopathic arthritis (pJIA). Credit: Janssen Biotech, Inc. The 4ml single-use vial of SIMPONI ARIA contains 50mg of golimumab. Credit: A2-33. SIMPONI ARIA acts as a tumor necrosis factor (TNF)-blocker.

SIMPONI ARIA (golimumab) is a fully human anti-tumour necrosis factor (TNF) alpha monoclonal antibody.

It is indicated for the treatment of moderate-to-severe active rheumatoid arthritis (RA) and active ankylosing spondylitis (AS) in adult patients, as well as active polyarticular juvenile idiopathic arthritis (pJIA) and active psoriatic arthritis (PsA) in patients aged two years and older.

SIMPONI ARIA is available in a single-use vial as a colourless to a light-yellow solution in 50mg / 4ml (12.5mg / ml) dosage strength for intravenous administration.

Discovered and developed by Janssen Biotech, golimumab was initially approved as a subcutaneous injection under the trade name Simponi by the US Food and Drug Administration (FDA) for the treatment of RA, PsA and AS in adult patients in 2009.

SIMPONI was approved in Europe for the treatment of moderate-to-severe RA, active and progressive PsA, severe, active AS, active ulcerative colitis, severe active non-radiographic axial spondyloarthritis and pJIA.

In July 2013, the intravenous form of golimumab obtained FDA approval under the trade name Simponi Aria for the treatment of moderate-to-severe active RA in combination with methotrexate (MTX).

The company submitted two supplemental biologics license applications (sBLAs) for Simponi Aria to the FDA for the treatment of PsA and AS in adult patients in December 2016. The applications were approved in October 2017.

The FDA also received two sBLAs for Simponi Aria for the treatment of active pJIA and PsA in paediatric patients in April 2020. The drug was approved for the indications in September 2020.

SIMPONI ARIA is marketed in 24 countries for one or more of the aforementioned indications.

Juvenile idiopathic arthritis (JIA), previously known as juvenile rheumatoid arthritis, is an arthritis-like inflammatory condition in children characterised by joint swelling, stiffness and pain, persistent for at least six weeks.

The polyarticular form of JIA is most common and is characterised by inflammation in more than four joints, closely resembling adult RA.

PsA is a chronic inflammatory disease characterised by both joint inflammation and skin lesions associated with psoriasis. PsA in paediatric patients is one of the rarest forms of JIA, observed in 2% to 11% of JIA patients.

Other characteristics of psoriatic arthritis include finger and nail defects or complications with the eye.

Golimumab is an anti-TNF biologic agent that binds to soluble and transmembrane bioactive forms of human TNF-alpha, a cytokine protein whose overproduction in the body leads to several chronic inflammatory diseases.

Inhibition of the interaction of TNF-alpha to its receptors inhibits its biological activity.

FDA approval of SIMPONI ARIA for pJIA is based on results from the open-label, multi-centre, phase three clinical trial, GO-VIVA.

SIMPONI ARIA is available in a single-use vial as a colourless to a light-yellow solution in 50mg / 4ml (12.5mg / ml) dosage strength for intravenous administration.

The trial evaluated the safety and efficacy of SIMPONI ARIA in 127 patients with pJIA aged two years to 17 years, following MTX treatment for at least two months.

The efficacy of the drug was consistent with responses in adult patients with RA through 52 weeks.

SIMPONI ARIAs pharmacokinetic (PK) exposure was consistent with the two pivotal phase three clinical trials in adult patients with moderate-to-severe active RA and active PsA.

The safety profile established for SIMPONI ARIA in paediatric patients was also consistent with the results in adult RA and PsA patients.

Common side-effects of SIMPONI ARIA reported in patients during the clinical trial are viral infections, upper respiratory tract infection, increased levels of alanine aminotransferase and aspartate aminotransferase, decreased neutrophil count, rash, bronchitis and high blood pressure.

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SIMPONI ARIA (golimumab) for the Treatment of pJIA - Clinical Trials Arena

An arthritis diet should focus on anti-inflammatory foods like fruits and vegetables.

Image Credit: SDI Productions/E+/GettyImages

There's no magic bullet when it comes to treating arthritis, unfortunately. But if you have the condition, you might find some symptom relief by changing what you eat.

Here's the breakdown on how diet and arthritis are linked, and the best and worst foods to eat for joint pain, stiffness and swelling.

The Inflammation Connection

There are more than 100 types of arthritis, but each is marked by chronic inflammation in the joints that can cause swelling and pain, according to the Mayo Clinic.

Acute or short-term inflammation is actually a healthy response that helps protect the body. A fever, which helps you fight off infection, is an example of acute inflammation. This type of inflammation goes away when the threat to the body is gone, according to a December 2019 paper published in Nature Medicine.

Chronic or long-term inflammation is that same response, but all the time. You don't go walking around with a fever 24/7, but inflammation is present in your body to a lesser extent. This chronic inflammation is linked to conditions such as heart disease, type 2 diabetes and metabolic syndrome, according to the Nature Medicine paper.

"Diet can absolutely impact arthritis be either exasperating inflammatory symptoms or by quieting inflammation."

Inflammation occurs for different reasons across the various types of arthritis. In osteoarthritis, the most common type, inflammation is caused by wear and tear on the joints, according to the Centers for Disease Control and Prevention (CDC). Rheumatoid arthritis (RA), on the other hand, is an autoimmune disease, so inflammation occurs because the body mistakenly attacks the joints, per the CDC.

Tamping down that inflammatory response can help manage the pain and other uncomfortable symptoms of arthritis, and that's where your diet comes in: Certain foods can increase or decrease inflammation in the body.

"At the root of the pathology of arthritis is chronic and unchecked inflammation," says Liz Wyosnick, RDN, dietitian and owner of Equilibriyum in Seattle, Washington. "Diet can absolutely impact arthritis be either exasperating inflammatory symptoms or by quieting [inflammation]."

Foods to Limit or Avoid With Arthritis

According to the Arthritis Foundation, the following foods can trigger or worsen inflammation:

This really means "added sugar," which is sugar added to food during processing (think: sweetened beverages like soda and snack foods). You should limit your added sugar to 6 teaspoons per day for women and children, and no more than 9 teaspoons per day for men, according to the American Heart Association.(For reference, 6 teaspoons is about 25 grams and 9 teaspoons is about 38 grams; a 12-ounce can of Coke has 39 grams of sugar.)

Limiting the amount of saturated fat in your diet means eating less red meat, whole-fat dairy, butter and cheese.

Decreasing saturated fats in the diet and replacing them with monounsaturated fats (like nuts, avocado and vegetable oils) may help reduce the progression of knee osteoarthritis, according to March 2017 research published in Arthritis Care and Research.

These are manmade fats that the Food and Drug Administration banned as an ingredient in foods in 2015. However, they're still found in very small amounts in processed baked good and shelf-stable foods that have "partially hydrogenated" in the ingredients list. Here are six foods to avoid.

Omega 6s aren't bad per se, but the issue is when the ratio of omega-6s to omega-3s is off. The goal is to lower the ratio, which means less omega-6 fatty acids and more omega-3s to help reduce the pain associated with arthritis inflammation, according to a February 2018 article published in the Clinical Journal of Pain.

Try to steer clear of processed meats and opt instead for seafood and leaner cuts of grass-fed meat.

Aim to eat a 3- to 6-ounce serving of fatty fish two to four times a week, per the Arthritis Foundation, and opt for fish that are relatively low in mercury, such as salmon, sardines, Atlantic mackerel and black cod.

Gluten is the protein found in wheat, rye and barley, while casein is a protein found in dairy foods. If you have a sensitivity to either of these, this could trigger an inflammatory response.

The link isn't entirely clear, but some individuals with rheumatoid arthritis have found relief by sticking with a gluten-free vegan diet, according to February 2018 research published in Open Rheumatology Journal.

"The underlying theory is that when you go on a plant-based diet, you cut back on animal products (dairy and meat), and hence, exclude most of the foods that promote inflammation, which helps control your RA symptoms," Febin Melepura, MD, medical director at the Sports & Pain Institute of New York, tells LIVESTRONG.com. "In contrast, diets high in animal products and low in fiber might aggravate your arthritis or cause more flare-ups."

What to Eat When You Have Arthritis

Fatty fish like salmon are rich in inflammation-fighting omega-3s.

Image Credit: kajakiki/E+/GettyImages

A diet focused on easing arthritis symptoms typically includes foods that can help decrease inflammation, not promote it. But "there's no one-size-fits-all approach," Dr. Melepura says. "What works for one may not work for another."

With that in mind, here are some loose guidelines to follow, but be sure to adjust where you need to based on your individual symptoms.

It's no secret that fruits and vegetables are recommended for good health, but their role in helping relieve arthritis pain lies in special compounds called phytochemicals, which are responsible for fighting inflammation.

"I would particularly recommend including fruits such as pomegranates, blueberries, raspberries and strawberries," Dr. Melepura says, "as they are a rich source of polyphenols including anthocyanins, quercetin and various types of phenolic acids. All these compounds are widely known for their potent anti-inflammatory effects."

Herbs and spices are also a source of anti-inflammatory compounds.

"Parsley, basil, cilantro, gingerroot, cinnamon and turmeric are some of the most nutrient-dense and anti-inflammatory foods available, so I guide people to incorporate these at most meals," Wyosnick says.

These special fats are found mainly in fish, but you can also find them in walnuts, flaxseeds and chia seeds. Dr. Melepura calls these "joint-friendly fats" and says "studies show that consumption of omega-3 fats lowers the levels of two inflammatory proteins, which are C-reactive protein (CRP) and interleukin-6." It should be noted, though, that this has been shown in people with fairly serious diseases, so the research may not translate for those with minor arthritis.

Olive oil is a major component of the Mediterranean diet, which is filled with fruits and vegetables, fish, legumes and nuts. Olive oil is a monounsaturated fat and researchers believe it's one of the reasons why the Mediterranean diet is good for reducing inflammation.

Extra-virgin olive oil specifically has been shown to improve gut health and also cut back on inflammation in the body, according to August 2019 research published in Nutrients.

To help tame arthritis inflammation, fill your plate with fruits and vegetables, lean proteins, fatty fish and healthy fats, such as olive oil. Cut back on sugar and saturated fats, and avoid trans fats completely.

Navigating Your Arthritis With Diet

If your specific type of arthritis has you confused about which type of foods you should eat, don't let that worry you. "An anti-inflammatory eating pattern can be perfectly safe for any type of arthritis," Wyosnick assures.

If you have food allergies or want to confirm an allergy or intolerance that may be aggravating your arthritis pain, speak with your doctor.

In addition, a registered dietitian can help you evaluate your current diet, remove troublesome foods from your diet and add in foods that may help provide some relief.

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The Best and Worst Foods to Eat When You Have Arthritis - LIVESTRONG.COM

A GLADSTONE man caught drug driving said he drank speed to help with his arthritis.

Mark Leslie Gordon, 55, pleaded guilty in Gladstone Magistrates Court on Monday to drug driving.

He was intercepted on the Dawson Highway, West Gladstone, on July 25 where he returned a positive drug test.

Further tests showed the presence of MDMA and methamphetamine.

Gordon was caught once again on September 6 on Campbell St.

He told police he drank speed to help with his arthritis.

Further tests showed the presence of THC and meth in his system.

During a search, police located a white crystal substance which weighed less than 1g, which Gordon said was speed.

Defence lawyer Cassandra Ditchfield said her client had been on a waiting list for five years to see a surgeon to treat his rheumatoid arthritis which caused him pain.

She said a friend had suggested he try using the drug to treat the pain as he was not willing to use prescription pain killers due to a family history of liver failure.

She asked the court to consider Gordon had no offending for 11 years.

Gordon was fined $1000 and disqualified from driving for four months.

Convictions were recorded.

Read more drug driver stories:

Mechanic loses licence for half a year

Gladstone man stopped drug driving on way home from library

Recreational user had drugs left over from party

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Man drank speed to help with arthritis - Observer

Arthritis affects over 350 million people in the world.

It is also a leading cause of disability and can affect mobility and interrupt peoples ability to perform simple daily tasks.

World Arthritis Day was on October 12, which aimed to raise awareness about rheumatic and musculoskeletal diseases. Although strides have been made to find suitable treatments, many continue to suffer from debilitating pain.

Owner and founder of The Harvest Table, Catherine Clark, said there are natural remedies which can help manage symptoms associated with arthritis.

There is no cure for arthritis, but if you support your body with the right foods and supplements, you can alleviate some of the pain so that it doesnt become a hindrance in your daily life, said Clark.

Clark added that arthritis can affect ones energy levels, cause pain, and is a direct result of a loss of collagen in the bones.

The key is to find solutions that will help you feel less fatigued, while also managing pain and replenishing the collagen lost, she said.

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Clark offers three natural remedies to manage arthritis pain:

Anti-inflammatory foodsArthritis fatigue is real, and according to the Arthritis Foundation, unchecked inflammation and pain largely contribute to your energy levels, along with certain medications that can cause drowsiness.Boosting your energy starts with nourishing your body with the right foods, especially those with high anti-inflammatory properties that help your bodies repair process. This will not only alleviate pain but will reduce the inflammation in your body. To effectively manage your arthritis, reduce the amounts of processed foods and saturated fats as these will only further contribute to your symptoms. Instead, choose fresh fruits and vegetables, especially green vegetables and berries. Also include fish and nuts, which both contain high anti-inflammatory properties.

Slow and gentle movementMovement is a critical part of recovery when addressing the symptoms of arthritis as it retains the suppleness of your joints. Various low impact movements can specifically tackle flexibility, strength and generally support your joints to prevent injury. Prolonged lack of movement can lead to chronic stiffness that results into joint immobility which will impact your ability to complete daily activities. Yoga is an effective solution as it reduces joint pain and also eases stress, tension and promotes better quality sleep.

Collagen-rich supplementsCollagen consists of protein building blocks, otherwise known as amino acids, which aid in cushioning our joints. When you have arthritis, this cushioning diminishes which then affects your cartilage and leads to your bones rubbing against each other without protection. Supplements like Bone Broth and Collagen granules help replenish the collagen content in your body. Bone Broth is a natural anti-inflammatory, so when you have it as part of your diet, you benefit in more ways than one. Collagen granules can help reduce both osteoarthritis and rheumatoid arthritis joint pain, improve flexibility, and helps form new bones. Although all the collagen you ingest does not go straight to your bones, increasing your intake makes them readily available for your body tissues.

Natural remedies are meant to support your body so that you can better manage pain and other symptoms associated with arthritis. The idea is to implement small and manageable changes that contribute to you feeling better and having the energy and ability to get through the day without pain getting in the way, Clark concludes.

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Photo of Try these three natural remedies to manage arthritis pain - Kempton Express

16 October 2020

Scientists from the University of Sheffield and University of Manchester have been awarded 265,000 from the British Heart Foundation, to investigate the links between vascular dementia and heart disease, and test whether a drug currently used to treat arthritis could also be used as a treatment for vascular dementia.

Vascular dementia is common, accounting for 15 percent of all cases of dementia. Caused by an impaired blood flow to the brain, symptoms of vascular dementia include confusion, slow-thinking, and changes in mood and behaviour.

Heart disease is a known risk factor for vascular dementia, and preliminary research by the Sheffield scientists has shown that blood flow in the brain is substantially affected by heart disease. The new study will continue this research to examine in more detail how heart disease and vascular dementia interact together, potentially making the disease burden worse.

The project will also investigate an anti-inflammatory treatment to reduce neuroinflammation in the brain and test whether this slows down, or reduces the severity of, vascular dementia.

Led by Professor Sheila Francis, from the University of Sheffields Department of Infection, Immunity, and Cardiovascular Disease, the project brings together the disciplines of cardiovascular biology and pathology, neurovascular function and neuropathology.

Dr Jason Berwick and Dr Clare Howarth from the Department of Psychology at the University of Sheffield also make up members of the research team who worked in collaboration with a team from the University of Manchester led by Professor Stuart Allan and Dr Emmanuel Pinteaux.

Professor Sheila Francis, from the University of Sheffield, said: We noticed quite a few years ago that laboratory mice with severe atherosclerosis (a type of heart disease) exhibited significant behaviour changes. On closer examination, their neurovascular function was altered, leading to the death of brain neurons and increased brain inflammation caused by a protein called interleukin-1.

The study will compare this new model with the commonly used laboratory models of vascular dementia to investigate whether an anti-inflammatory drug against interleukin-1 already used successfully to treat arthritis and in clinical trials for use in stroke patients, could also improve neurovascular function in both cases.

Professor Stuart Allan from the University of Manchester, commented: We are delighted to be involved with this project. We have worked on the role of the protein interleukin-1 in stroke for many years. Our research has led to several clinical trials of an anti-interleukin-1 therapy in stroke, and the possibility that this same treatment might work in vascular dementia is really exciting.

It is hoped the study will lead to anti-interleukin-1 therapies becoming a useful treatment for vascular dementia.

The work forms part of the research of two of the flagship institutes at the University of Sheffield:

Subreena Simrick, Senior Research Adviser at the BHF, said: There is no cure for vascular dementia. Currently, all that doctors can do is prescribe drugs which can slow down its progression.

By funding this research, we hope to take a step towards changing that and bring hope to people affected by this cruel disease.

Unfortunately, our ability to fund important research like this is threatened by the impact of coronavirus on our fundraising. Now, more than ever, we need the support of the public so we can continue to support projects that could transform the lives of those with heart and circulatory diseases.

The University of Sheffield

With almost 29,000 of the brightest students from over 140 countries, learning alongside over 1,200 of the best academics from across the globe, the University of Sheffield is one of the worlds leading universities.

A member of the UKs prestigious Russell Group of leading research-led institutions, Sheffield offers world-class teaching and research excellence across a wide range of disciplines.

Unified by the power of discovery and understanding, staff and students at the university are committed to finding new ways to transform the world we live in.

Sheffield is the only university to feature in The Sunday Times 100 Best Not-For-Profit Organisations to Work For 2018 and for the last eight years has been ranked in the top five UK universities for Student Satisfaction by Times Higher Education.

Sheffield has six Nobel Prize winners among former staff and students and its alumni go on to hold positions of great responsibility and influence all over the world, making significant contributions in their chosen fields.

Global research partners and clients include Boeing, Rolls-Royce, Unilever, AstraZeneca, GlaxoSmithKline, Siemens and Airbus, as well as many UK and overseas government agencies and charitable foundations.

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Arthritis drug to be investigated as possible treatment for vascular dementia - Latest - News - The - University of Sheffield News

The latest report on the Rheumatoid Arthritis Therapeutics market is an all-inclusive assessment of the business sphere and highlights the vital parameters of the industry including current trends, industry size, market share, present renumeration, periodic deliverables, and profit estimates over the forecast timeline.

New Market Research Report on Rheumatoid Arthritis Therapeutics Market size | Industry Segment by Applications (Prescription and Over-the-Counter (OTC), by Type (Pharmaceuticals and Biopharmaceuticals), By Regional Outlook - Global Industry Analysis, Size, Share, Growth, Opportunity, Latest Trends, and Forecast to 2025.

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Rheumatoid Arthritis Therapeutics Market: Development Factors and Investment Analysis by Leading Manufacturers - Express Journal

HOLMDEL, N.J., Oct. 20, 2020 /PRNewswire/ -- The 5th Annual Companion Diagnostics Forum will take place Tuesday and Wednesday, October 27-28, 2020. Register at http://companiondiagnosticsforum.com.

"The online Companion Diagnostics Forum is focused on the need for Companion Diagnostics to grow and keep pace with novel developments in Pharma," said Event Chair Oscar Puig from Eli Lilly, adding, "We are providing access to key people in this important field that are working every angle to ensure patients get the personalized medicine they require."

Keynote speaker Steve Anderson, CSO from Covance, explained that"Companion diagnostics are a critical component for delivering on the promise of precision medicine. This conference brings together industry leaders to discuss and review innovations and emerging applications in companion diagnostics."

Some of the therapeutic areas that will be covered are Oncology, ALS and trauma-related disorders. Education, regulations and adoption in clinical applications will be discussed at this year's forum. Speakers will addresshow these various areas are combining to bring better healthcare to patients.

Ronnye Schreiber, CEO, PlanetConnect and event organizer, said, "We are pleased that we can offer this custom virtual environment to ensure that the Forum could move forward even though we cannot meet in-person."

See a complete agenda and register online at http://www.companiondiagnosticsforum.com.

About PlanetConnect The Companion Diagnostics Forum is produced by PlanetConnect, a certified woman-owned conference producer and event production company with more than 25 years experience running scientific symposia for pharmaceutical, research, IT and manufacturing organizations. With decades of experience providing cost-effective, creative solutions, PlanetConnect enables companies to focus on making meaningful connectionsnot just meetings.

Contacts:Event Chair: Oscar Puig, Translational Medicine, Oncology Late Stage Development, Eli Lilly [emailprotected] Event Manager: Ronnye Schreiber, CEO, PlanetConnect, [emailprotected]

SOURCE PlanetConnect

http://www.planetconnect.com

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The 5th Annual Companion Diagnostics Forum on Oct 27-28 gathers scientists, clinicians, regulators and industry professionals for two days of...

Data from a 5-year open-label treatment period on the safety profile of erenumab (Aimovig) showed the treatment helped patients with episodic migraine (EM) achieve a sustained reduction in the number of monthly migraine days (MMD) and the number of days in which therapies were needed for acute migraines.

The set of data we have now obtained is very, very important from the clinical point of view,said Messoud Ashina, MD, PhD, professor of neurology in the Faculty of Health and Medical Sciences at theUniversity of Copenhagen and lead investigator of the study.

Erenumab, which wasapprovedby the FDA in 2018, is a calcitonin gene-related peptide (CGRP) inhibitor administered via self-injection once a month. The treatment blocks the CGRP receptor, which is believed to play a crucial role in migraine. Erenumab can be injected as a 70- or 140-mg dose in adults with migraine. Results from the phase 2 study were initially published during the Migraine Trust Virtual Symposium.

In an interview with The American Journal of Managed Care (AJMC), Ashina reviewed the findings and discussed potential next steps for the treatment.

The sustained efficacy of erenumab is integral, as many migraineurs experience a wearing off of treatment effects after 3 or 4 months on a single preventive therapy, Ashina explained. Furthermore, the study found that erenumabs safety profile was nearly identical to that observed during the double-blind period, and no additional adverse reactions were reported. The most common adverse events included nasopharyngitis and upper respiratory tract infections.

Although roughly 70% of the 216 patients enrolled in open-label phase of the study reported long-term efficacy, researchers do not yet know what accounts for the heterogeneity in terms of response. So far, we havent found any predictors for efficacy, and we need more research and more new studies to explain why this group of patients does not respond to monoclonal antibodies, Ashina said.

Currently, the Efficacy and Safety of Erenumab in Pediatric Subjects with Episodic Migraine (OASIS EM) trial is underway. When it comes to the treatments effects in pediatric populations, Ashina expects to see similar long-term results. This is one of the areas with a huge unmet need for new treatments, he said. Medications currently available for children can have side effects and adverse events, making some specialists hesitant to prescribe preventive treatments to younger populations.

Based on the safety and tolerability that we see in an adult population [with erenumab], we would expect to also see positive results in children, as this population also has a high frequency of episodic migraine, Ashina said. But lets see, because we havent seen data yet.

OASIS EM is estimated to be completed in August 2025.

In addition to studies on erenumabs efficacy in children, Ashina noted that future studies ought to be conducted on predicting the treatments efficacy in patients. If predictive markers of efficacy are found, this will also pave the way for personalized medicine in the future.

The second issue is with erenumab and also other monoclonal antibodies is about safety and tolerability in patients with different comorbidities, Ashina explained. As most clinical trials do not include patients with serious comorbidities, real-world data will be essential to understand the effects of erenumab on these patients.

Registry studies can also be used to track any effects that monoclonal antibody treatments may have on pregnant women. Erenumab is currently contraindicated during pregnancy, but you can imagine that when you have a drug with a long half-life, and if you get pregnant, it might theoretically affect the baby, Ashina said.

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Dr Messoud Ashina Talks Through the 5-Year Safety and Efficacy Data on Erenumab - AJMC.com Managed Markets Network

CHICAGO, Oct. 20, 2020 /PRNewswire/ -- According to the new market research report "Research Antibodies and Reagents Marketby Product (Antibodies (Type, Form, Source, Research Area), Reagents), Technology (Western blotting, Flow Cytometry), Application (Proteomics, Drug Development), End User - COVID-19 Impact - Global Forecast to 2025",published by MarketsandMarkets, the global market size is projected to reach USD 14.1 billion by 2025 from USD 10.1 billion in 2020, at a CAGR of 6.7% during the forecast period.

The growth is due to evolution of market owing to factors such as growth in proteomics and genomics research, rising demand for high-quality antibodies for research reproducibility, and increasing R&D activity and expenditure in the life sciences industry. Fueled by the growing demand for personalized medicine and structure-based drug design, the global market is expected to witness significant growth in the coming years.

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The COVID-19 outbreak has boosted research activity due to efforts to understand the dynamics of the infection. We estimate that the major share of research antibody and reagent manufacturing, along with personalized medicine, will grow at a stable pace in the next five years. Due to the increase in research activity, both the availability of funding for research and the demand & manufacturing of reagents and antibodies are expected to grow. As companies after pandemic have scaled up their operations for testing and tracking the infection of COVID-19. This has given a chance for growth in profits for companies operating in the NGS and PCR markets. The growth in revenue is 57%, as COVID-19 testing has increased with the use of the latest technology of genetic and molecular testing. The shift in demand for research for COVID-19, neurobiology, and oncology has created a huge scope for testing solutions, such as western blotting, flow cytometry, ELISA, and drugs for researchers and laboratories.

The antibodies segment is expected to grow at the highest CAGR during the forecast period

Based on product, the research antibodies market is segmented into reagents and antibodies. The antibodies segment is expected to grow at highest CAGR in forecast period. This is due to the research-use antibodies offer high specificity and selectivity and are used ubiquitously in biochemical and medical research for protein-target identification, regulatory characterization, and discovery.

The primary antibodies segment is accounts for the largest share of the research reagents market

Based type, the research reagents market is segmented into primary antibodies and secondary antibodies. The primary antibodies segment held the largest share of the global research antibodies market in 2019. This segment is witnessing a strong growth due to the use of these antibodies in numerous types of assay formats. Their accuracy in biomarker detection and their high specificity and sensitivity are also driving their adoption

The media & sera reagent is expected to account for the largest share of the market, by type, in 2019

Based type, the research antibodies and reagents market is segmented into media &sera, stains & dyes, fixatives, buffers, solvents, enzymes, probes and other reagents. The media & sera reagent segment held the largest share of the global research antibodies market in 2019. The large share of this segment is primarily attributed to the use of these components in all types of assays, cell cultures, and techniques.

The western blotting segment is expected to account for the largest share of the market, by technology, in 2019

Based on technology, the research antibodies market is segmented into western blotting, flow cytometry, ELISA, Immunohistochemistry, Immunofluorescence, Immunoprecipitation, and other technologies. Western blotting segment is expected to grow at highest CAGR in forecast periods (2020-2025). This is due to the high adoption of this technique in proteomic and genomic research. The results achieved are easy to interpret, unique, and unambiguous, making it suited for evaluating levels of protein expression in cells, monitoring fractions during protein purification, and comparing the expression of a target protein from various tissues.

The pharmaceutical & biotechnology segment is expected to grow at the highest CAGR during the forecast period

Based on end user, the research reagents market is segmented into the pharmaceutical & biotechnology companies, academic & research institutions and Contract Research Organizations. The growth of this segment is due to antibodies provide a gold standard for the detection of a biomolecule or a pathway and are even capable of detecting specific changes in potential drug targets. Additionally, highly specific reagents are used to measure pharmacokinetic parameters in the preclinical and clinical development of biological drugs. The increasing demand for personalized medicine and government initiatives in this sector are the key market drivers for this segment.

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The APAC market is expected to grow at the highest CAGR during the forecast period

The Asia Pacific research reagents market is expected to grow at the highest CAGR from 2020 to 2025.The growth of this market is primarily due to growing proteomics and genomics research and increasing research funding, investments by pharmaceutical and biotechnology companies, and growing awareness of personalized therapeutics in the region. Also, high-growth countries, such as China, India, Japan, South Korea, Taiwan, Australia, and Singapore are the major contributors to the Asia Pacific research antibodies and reagents market. This region is expected to grow at the highest pace during the forecast period primarily due to growing proteomics and genomics research and increasing research funding, increasing investments by pharmaceutical and biotechnology companies, and growing awareness about personalized therapeutics.

The prominent market players are Thermo Fisher Scientific (US), Merck Group (Germany), Abcam plc (UK), Becton, Dickinson and Company (US), Bio-Rad Laboratories (US), Cell Signaling Technology (US), F. Hoffmann-La Roche (Switzerland), Danaher Corporation (US), Agilent Technologies (US), PerkinElmer (US), Lonza (Switzerland), GenScript (China), and BioLegend (US).

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Research Antibodies and Reagents Market worth $14.1 Billion by 2025 - Exclusive Report by MarketsandMarkets - PRNewswire