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Sarepta, continuing its gene therapy push, helps launch a startup – BioPharma Dive

October 25th, 2020 5:58 am

Dive Brief:

Sarepta is best known for its RNA technology platform, which has led to two approved though also controversial drugs for Duchenne muscular dystrophy.

Yet, Sareptais also deeply invested in gene therapy, having developed an extensive list of more than two dozen experimental treatments, six of which have reached human testing.

Rare diseases have been an early target in this rapidly growing field. The two gene therapies approved in the U.S., Roche's Luxturna and Novartis' Zolgensma, are respectively used to treat an uncommon form of blindness and a muscle disease that occurs in about 1 in every 10,000 births.

Sarepta'stherapies target a wide variety of rare diseases, including Duchennemuscular dystrophy, Pompe disease, and types of Limb-girdle muscular dystrophy. Taking a stake in AavantiBio, with its work in Friedreich'sataxia, could expand Sarepta'sreach even further. The disease affects approximately 1 in every 40,000 people, according to the National Organization for Rare Disorders, which would equate to around 8,200 patients in the U.S.

"Our equity participation in AavantiBio serves our strategy to build our gene therapy engine through targeted investment in potentially life-enhancing therapies,"Doug Ingram, Sarepta'sCEO, said in a statement Thursday.

AavantiBio joins a couple large, powerful companies in the hunt for a gene therapy to treat Friedreich's ataxia. Pfizer and Novartis are each working on their own programs.

Outside of gene therapy, Reata Pharmaceuticals disclosed last year positive datafrom a study that tested an oral drug, known as omaveloxolone,in patients with Friedreich's ataxia. Reata said it intends to file the drug for approval based on those results.

AavantiBiowill be headquartered in the greater Boston area, putting it close by Cambridge, Massachusetts-based Sarepta. Cumbo, along with his role as CEO, will take one of AavantiBio'seight board of directors seats. Cumbohas, during the span of his career, helped launch 11 specialty products across multiple drug companies, including Sarepta, Gilead and Vertex, where he built a sales team for the hepatitis C drug Incivek.

Co-founders Byrne and Corti will be on the board too, alongside two independent directors and representatives from the investor group of Perceptive, Bain and RA.Louise Rodino-Klapac, senior vice president of gene therapy for Sarepta, will serve as a board observer.

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Resurgence of gene therapy has dramatically altered the the biomedicine revolution – Genetic Literacy Project

October 25th, 2020 5:58 am

Some technologies that have emerged and altered the landscape in recent years include immunotherapy, CRISPR-Cas9 gene editing, and chimeric antigen receptor (CAR) T-cell therapies. Now, another platform technology is maturing from the research laboratory to commercial viability. In 2017, the U.S. Food and Drug Administration (FDA) approved the first directly administered gene therapy for mutations of a specific, disease-related gene. That product, Luxturna, marketed by Spark Therapeutics, delivers a functioning copy of the RPE65 gene to retinal cells using an adeno-associated virus (AAV) as a vector to treat a genetic form of blindness.

This advance has injected new energy into biotech startups seeking to capitalize on gene therapy.

As the field matures, gene therapy companies will eventually need to find a way to sell once-in-a-lifetime cures in a market built around chronic therapies. In some ways, its been easier for our European counterparts and other single-payer economies, [research analyst Mani] Foroohar comments. [They] can rest more assured that the financial benefits of reducing future hospitalizations due to expensive future illness will be captured by the same payor thats providing the upfront outlay.

Just as biotechnology has transformed every aspect of our healthcare system over the last 40 years, gene therapy will challenge, disrupt, and overturn our healthcare pricing and reimbursement paradigms as it becomes an increasingly common and routine treatment approach.

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SparingVision Nabs 44.5 Million to Support Gene Therapy, Adds New CEO – BioSpace

October 25th, 2020 5:58 am

Paris-based SparingVision, a genomic medicine company focused on ocular diseases, raised 44.5 million (approximately $52.2 million) in a financing round. Funds will be used to advance the development of the companys treatment for a genetic eye disorder that can lead to vision loss.

SparingVision is developing SPVN06 for the mutation-agnostic treatment of retinitis pigmentosa, the most common inherited retinal degeneration that affects about two million people globally. There is currently no approved treatment to treat all genetic forms of this rare retinal disease that leads to blindness, the company said. According to SparingVision, SPVN06 is a proprietary, mutation-agnostic, AAV gene therapy consisting of one neurotrophic factor and one oxidative stress reducing enzyme which, acting synergistically, aim to slow or stop the degeneration of photoreceptors. Loss of photoreceptors leads to blindness in retinitis pigmentosa. In June, the European Commission granted Orphan Drug designation to SPVN06

In addition to advancing its gene therapy treatment, funds from the financing round will be used to support SparingVisions GMP activities, including the manufacturing of a first clinical batch of the product, as well as regulatory activities. Funds will also be used to begin human trials of the gene therapy, which are set to begin in 2021.

Gene therapy has already been approved by regulatory to approve a type of genetic blindness. Spark Therapeutics, now a division of Roche, won regulatory approval for Luxturna (voretigene neparvovec), a gene therapy for a rare, genetic form of blindness. Luxturna is approved for the treatment of pediatric and adult patients with confirmed biallelic RPE65 mutation-associated retinal dystrophy. The disease can lead to vision loss and may cause complete blindness in certain patients. The approval marked the first time the U.S. Food and Drug Administration approved a directly administered gene therapy that targets a disease caused by mutations in a specific gene.

In addition to developing its gene therapy for retinitis pigmentosa, SparingVision said it intends to establish a toehold in the United States and will expand its management team.

The financing round was led by 4BIO Capital and UPMC Enterprises. It was supported by Jeito Capital and Ysios Capital. Current investors Bpifrance and Foundation Fighting Blindness also participated in the round. Torreya Capital, LLC served as exclusive placement agent for the offering.

In addition to the financing, Stphane Boissel, who currently serves as chairman of the board of directors, was named chief executive officer of the company. He takes over from Florence Allouche, a cofounder of the company. Boissel, who previously served as head of corporate strategy at Sangamo Therapeutics, said the support SparingVision received in the financing round demonstrates the excitement about the potential of SPVN06.

With its singular mutation-agnostic approach, SPVN06 could have a much broader commercial potential than most gene therapy products for RP currently in development and will be used as an anchor to build an economically-viable portfolio of therapies in the field of ophthalmology. Our shareholders, both new and existing, are all long-term, strategic and patient-centric investors that share our vision and we are excited to be working with them to achieve our goals, Boissel said in a statement.

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Sana CEO reveals details about stealthy gene therapy startup that has raised more than $700M – GeekWire

October 25th, 2020 5:58 am

Luke Timmerman interviews Sana Biotechnology CEO Steve Harr at the GeekWire Summit this week.

Sana Biotechnology CEO Steve Harr shed more light on one of most secretive, heavily funded startups in Seattle and the global biotech industry detailing its plans to create tools that replace and repair human body cells, with the potential to treat various diseases and create new medicines.

Harr spoke with biotechnology journalist Luke Timmerman, founder of The Timmerman Report, this week at the GeekWire Summit. Sana raised more than $700 million this summer in one of the largest venture financing deals in the life sciences industry and one of the biggest rounds on record in Seattle.

Founded in 2019, the 250-person company has an ambitious goal of both repairing cells in the body (gene therapy) and also replacing damaged cells (cell therapy). Its led by several former executives from Juno Therapeutics, another Seattle biotech company that went public in 2014 and sold to Celgene for $9 billion in 2018.

Sana has kept a relatively low profile since launching. It is competing with much larger entities that have deeper pockets and more robust logistics capabilities. But Harr said a startup such as Sana has a key differentiator.

We have one competitive advantage: we can make faster and better decisions, he said. We get there because we have better people, we have greater focus, and we have better communication.

Read on for key takeaways from the conversation.

How Sana started:Harr and his former colleagues at Juno learned a lot about engineering cells and manipulating genes during their startup journey. Juno was among a handful of U.S. companies making cutting-edge cancer immunotherapy treatments.

But they also knew there was more opportunity in a nascent industry of gene and cell therapy.

We wanted to build the transformative or winning company of this next era, of the next 20 years, Harr said. To do that, we had to break the model of what biotech is, which is typically taking an idea and figuring out where to apply it best.

Sana instead is trying to build the platform that can engineer cells and fix them, much like building a computer.

There are a whole host of component parts that go into it, Harr said. We have to aggregate the right technologies.

Harr said too many biotech companies sell solutions in search of problems. He likened it to someone showing up with a tiny screwdriver and looking for a loose screw to fix. Harr sees Sana more as a toolbox that can help build the right medicine for the right patient.

Sana is targeting various disease areas, including cancer, diabetes, genetic disorders, and more. They are relatively diverse, but there are some really fundamental underlying platform and strategy principles that drive each of those, Harr said.

Sanas secret sauce:One key focus for the company is reimagining the delivery system for these therapies how to get DNA, RNA, proteins, etc. into a cell. Ultimately at the core, what were trying to do is really improve delivery, and really figure out how to hide cells from the immune system, Harr said.

Hiding re-engineered or replaced cells from ones immune system is important to prevent the possibility of the body rejecting the new cells.

Harr also talked about delivering therapy via injection, with the body becoming the bioreactor. Its similar to technology built by Moderna and others. You deliver the tools to enable your body to make its own medicine, Harr said.

Manufacturing:Sana is also aiming to innovate how gene and cell therapies are produced and distributed at scale. They are typically expensive Timmerman said CAR T-cell immunotherapies for cancer ran in the $300,000-to-$400,000 range per patient. Figuring out manufacturing costs at scale and making it less than current alternative methods of care for patients will be key to the strength of Sanas business. Harr added that you have to do it in a way thats constructive for the system.

Headcount: Sana employs 250 people spread across offices in Seattle, the Bay Area, and Cambridge, Mass. Having three outposts helps the company attract the best talent, Harr said. One advantage to raising so much capital is being able to hire the best folks. Last month Sana added top scientists Ed Rebar and Terry Fry to the executive team.

If you really hire one of the true world leaders in something, it is pretty amazing how quickly teams form around them, Harr noted.

Money matters: Having more than $700 million in the bank helps Sana in various other ways. Harr said a lot of biotech companies often run what amount to experiments to justify raising more capital. We have the privilege of running experiments to find truth as fast as you want to, he said. And then we want to have the balance sheet, technologies, and people to be able to grapple with whatever the truth is.

Timeline: Harr said the company is on track with its original strategy but does not plan on selling medicine in the next two years. It will progress with multiple medicines in parallel, not one at a time, Harr said.

Leadership advice:During the pandemic and remote work, Harr said hes started to reach out to four-to-six people at Sana each week that he wouldnt normally talk with. He holds half-hour meetings to chat about what they are working on, and what leadership could do to make their life or job better. I found that to be just such an invigorating way to learn whats going on, he said.

[The full interview with Harr, and other GeekWire Summit sessions, are available on-demand exclusively to attendees of the virtual event.Learn more and register here.]

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Sana CEO reveals details about stealthy gene therapy startup that has raised more than $700M - GeekWire

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Axovant Gene Therapies to Host Virtual Parkinson’s Disease R&D Day on October 30, 2020 – BioSpace

October 25th, 2020 5:58 am

NEW YORK, Oct. 22, 2020 (GLOBE NEWSWIRE) -- Axovant Gene Therapies Ltd. (Nasdaq: AXGT), a clinical-stage company developing innovative gene therapies, today announced that it will host a virtual R&D Day on Friday, October 30, 2020 at 11:30 AM Eastern time, to discuss the Companys AXO-Lenti-PD gene therapy for Parkinsons disease.

Axovants Parkinsons disease R&D Day will be moderated by Chief R&D Officer, Gavin Corcoran, M.D., and will feature presentations on the current treatment landscape and unmet medical need for people living with Parkinsons disease from the following key opinion leaders:

In addition, the Company will present data from the second cohort of the Phase 2 SUNRISE-PD trial for AXO-Lenti-PD including:

Drs. Adler, Palfi, and Eberling will be joined by Dr. Corcoran to answer questions following the formal presentations.

AXO-Lenti-PD is the only investigational gene therapy for Parkinsons disease that delivers three genes via a lentiviral vector to encode a set of critical enzymes required for endogenous dopamine synthesis, with the goal of improving motor function and restoring steady, tonic levels of dopamine in the brain. The gene therapy aims to provide patient benefit for years following a single administration.

To register for the R&D webcast, please click here.

A live audio webcast of the R&D Day can be accessed through the Events & Presentations section of the company's website at investors.axovant.com. An archived replay of the webcast will be available on the company's website following the event.

Biographies of R&D Day Panelists:

Dr. Adler has received numerous grants to investigate experimental treatments for Parkinson's disease, essential tremor, dystonia, restless legs syndrome, and chronic traumatic encephalopathy (CTE). He serves as an advisory member to many different international medical societies such as the International Parkinson and Movement Disorder Society, MDS Industry Education and Services Committee, and the American Academy of Neurology Section of Movement Disorders. Dr. Adler has a commitment to education having trained residents, 14 fellows and graduate students, and has given many invited lectures. Dr. Adlers main research interests are investigating tissue diagnostic tests for Parkinsons disease, biomarkers for an early diagnosis of Parkinsons disease and PD with dementia, and identification of new treatments for PD and PD with dementia. He also has been investigating essential tremor, restless legs syndrome, and dystonia. He has published over 400 research papers and reviews, and edited a book entitled Parkinson's Disease and Movement Disorders: Diagnosis and Treatment Guidelines for the Practicing Physician. In 2006, Dr. Adler was awarded the Mayo Clinic Distinguished Investigator of the Year Award.

Dr. Palfi has published extensively on trophic factor- and enzyme-based gene therapy in Parkinsons disease and Huntingtons disease. He is a principal investigator on numerous preclinical and clinical studies and has been involved in studies of many novel agents including implanted brain devices, optogenetic, homeoprotein, trophic factors GDNF, CNTF and dopamine lentiviral vectors.

Dr. Eberling earned undergraduate and graduate degrees in biological psychology from the University of California at Berkeley, later moving to the Lawrence Berkeley National Laboratory where she developed expertise in neuroimaging techniques and gene therapy approaches for Parkinsons disease.

About Axovant Gene Therapies

Axovant Gene Therapies is a clinical-stage gene therapy company focused on developing a pipeline of innovative product candidates for debilitating neurodegenerative diseases. Our current pipeline of gene therapy candidates target GM1 gangliosidosis, GM2 gangliosidosis (also known as Tay-Sachs disease and Sandhoff disease), and Parkinsons disease. Axovant is focused on accelerating product candidates into and through clinical trials with a team of experts in gene therapy development and through external partnerships with leading gene therapy organizations. For more information, visit http://www.axovant.com.

Contacts:

Investors

Parag MeswaniAxovant Gene Therapies Ltd.(212) 547-2523investors@axovant.com

Media

Josephine Belluardo, Ph.D.LifeSci Communications(646) 751-4361jo@lifescicomms.commedia@axovant.com

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Axovant Gene Therapies to Host Virtual Parkinson's Disease R&D Day on October 30, 2020 - BioSpace

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Biogen finally culls MS dud opicinumab, adds SMA gene therapy to the garbage heap – FierceBiotech

October 25th, 2020 5:58 am

Biogen is cutting its experimental multiple sclerosis (MS) drug opicinumab as well as an spinal muscular atrophy (SMA) candidate amid a third-quarter clear-out.

First, to its MS drug. In its third-quarter financials posted Wednesday morning, the biopharma said: In October 2020 Biogen announced that the phase 2 AFFINITY study of opicinumab in MS did not meet its primary or secondary endpoints and that Biogen has discontinued development of opicinumab.

The anti-LINGO monoclonal antibody has experience with failure: All the way back in 2016, it posted a similar phase 2 flop after not hitting its primary and secondary endpoints for MS in the so-called SYNERGY trial.

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Back then, opicinumab was seeing whether it could have an effect on a multicomponent primary endpoint designed to assess ambulation, upper extremity function and physical disability in patients with relapsing forms of MS. Opicinumab, however, failed to outperform placebo in this regard.

A secondary efficacy endpoint, intended to evaluate the slowing of disability progression, also came up negative. But Biogen dug through the data, and, instead of culling it then and there, decided to carry on, saying: While we missed the primary endpoint, the SYNERGY study results suggest evidence of a clinical effect of opicinumab.

RELATED: Biogen tumbles on PhII MS flop, but refuses to write off drug

Biogen believed the data showed an increased clinical effect of opicinumab versus placebo (when used at the same time as interferon beta-1a intramuscular injection).

That led to the AFFINITY study, started in 2017, which looked at opicinumab as an add-on therapy in patients who are adequately controlled on their anti-inflammatory disease-modifying therapy (DMT), versus the DMT alone.

The primary endpoint of the study, overall response score, looked to assess the improvement and worsening of disability over time. Clearly, it failed to achieve this, though in its third-quarter update it did not reveal further details.

It also quietly announced it was throwing out BIIB089, an SMA gene therapy hopeful that had been on an IND hold due to dorsal root ganglion toxicity. Again, it did not any extra color to this cull in its financials.

The biopharma is now pinning its hopes on another failed drug, aducanumab, which it hopes can get past an FDA advisory committee early next month and a potential approval next year, though this controversial Alzheimers disease asset has been given low odds by analysts of managing that feat.

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Selecta Biosciences and AskBio Receive FDA Rare Pediatric Disease Designation for their Gene Therapy for Methylmalonic Acidemia – GlobeNewswire

October 25th, 2020 5:58 am

WATERTOWN, Mass. and RESEARCH TRIANGLE PARK, N.C., Oct. 20, 2020 (GLOBE NEWSWIRE) -- Selecta Biosciences, Inc. (NASDAQ: SELB) and Asklepios BioPharmaceutical, Inc. (AskBio), today announced the U.S. Food and Drug Administration (FDA) has granted Rare Pediatric Disease Designation to MMA-101 for the treatment of isolated methylmalonic acidemia (MMA) due to methylmalonyl-CoA mutase (MMUT) gene mutations. The FDA grants Rare Pediatric Disease Designation to incentivize development of new treatments for serious and life-threatening diseases that primarily affect children ages 18 years or younger with fewer than 200,000 people affected in the U.S. The Rare Pediatric Disease designation program allows for a Sponsor who receives an approval for a product to potentially qualify for a voucher that can be redeemed to receive a priority review of a subsequent marketing application for a different product.

This Rare Pediatric Disease designation from the FDA highlights the significant unmet medical need that Selecta and AskBio are seeking to address with MMA-101 for this rare metabolic disorder, said Carsten Brunn, Ph.D., chief executive officer of Selecta Biosciences. When used with AAV gene therapy vectors, Selectas ImmTOR aims to inhibit the immune response to the AAV vector, potentially allowing re-dosing of gene therapies. Ongoing clinical programs will focus on evaluating product candidate performance in patients who may have been underdosed or those who may lose transgene expression over time. Were honored to receive this recognition and look forward to advancing this program in hopes of helping young patients affected by MMA and their families.

MMA is a serious and potentially life-threatening inherited metabolic disorder that presents in patients from newborns to adulthood, said Sheila Mikhail, J.D., CEO and co-founder of AskBio. AskBio is committed to delivering transformative genetic medicines for rare diseases like this one, and the Rare Pediatric Disease designation helps us continue development of MMA-101.

AskBio and Selecta expect to initiate a Phase 1 clinical trial of MMA-101 and ImmTOR for patients with MMA in 1H 2021.

About Methylmalonic AcidemiaMethylmalonic Acidemia (MMA) is a rare monogenic disorder in which the body cannot break down certain proteins and fats. This metabolic disease may lead to hyperammonemia and is associated with long-term complications including feeding problems, intellectual disability, chronic kidney disease and inflammation of the pancreas. Symptoms of MMA usually appear in early infancy and vary from mild to life-threatening. Without treatment, this disorder can lead to coma and in some cases death.

About Selecta Biosciences, Inc.Selecta Biosciences, Inc. (NASDAQ: SELB) is leveraging its clinically validated ImmTOR platform to develop tolerogenic therapies that selectively mitigate unwanted immune responses. With a proven ability to induce tolerance to highly immunogenic proteins, ImmTOR has the potential to amplify the efficacy of biologic therapies, including redosing of life-saving gene therapies, as well as restore the bodys natural self-tolerance in autoimmune diseases. The companys first program aimed at addressing immunogenicity to AAV gene therapies is expected to enter clinical trials in early 2021 in partnership with AskBio for the treatment of methylmalonic acidemia (MMA), a rare metabolic disorder. A wholly-owned program focused on addressing IgA nephropathy driven by ImmTOR and a therapeutic enzyme is also in development among additional product candidates. Selecta recently licensed its Phase 3 clinical product candidate, SEL-212, in chronic refractory gout to Sobi. For more information, please visit http://www.selectabio.com. About AskBioFounded in 2001, Asklepios BioPharmaceutical, Inc. (AskBio) is a privately held, fully integrated AAV gene therapy company dedicated to developing life-saving medicines that cure genetic diseases. Its pipeline includes clinical-stage programs in Pompe disease and congestive heart failure and a diverse preclinical portfolio of therapeutics targeting neuromuscular, CNS and other diseases, as well as out-licensed clinical indications for hemophilia (Chatham Therapeutics, acquired by Takeda) and Duchenne muscular dystrophy (Bamboo Therapeutics, acquired by Pfizer). AskBios gene therapy platform includes Pro10, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, UK, the company has generated hundreds of proprietary third generation AAV capsids and promoters, several of which have entered clinical testing. An early innovator in the space, the company holds more than 500 patents in areas such as AAV production and chimeric and self-complementary capsids.

Selecta Forward-Looking StatementsAny statements in this press release about the future expectations, plans and prospects of Selecta Biosciences, Inc. (the company), including without limitation, statements regarding the unique proprietary technology platform of the company, and the unique proprietary platform of its partners, the potential of ImmTOR to enable re-dosing of AAV gene therapy, the potential treatment applications of product candidates utilizing the ImmTOR platform in areas such as gene therapy and MMA, the companys plans to initiate a clinical trial for a product candidate to treat MMA, the ability of the company and AskBio to develop gene therapy products using ImmTOR and AskBios technology, any development plans of the company and AskBio have for product candidates to treat serious and life-threatening diseases and the intention to seek regulatory approval thereof, the novelty of treatment paradigms that the Company is able to develop, the potential of any therapies developed by the company and AskBio to fulfill unmet medical needs, the companys plan to apply its ImmTOR technology platform to a range of biologics for rare and orphan genetic diseases, the potential of the companys intellectual property to enable repeat administration in gene therapy product candidates and products, the ability to re-dose patients and the potential of ImmTOR to allow for re-dosing, the potential to safely re-dose AAV, the ability to restore transgene expression, the potential of the ImmTOR technology platform generally and the companys ability to grow its strategic partnerships, and other statements containing the words anticipate, believe, continue, could, estimate, expect, hypothesize, intend, may, plan, potential, predict, project, should, target, would, and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including, but not limited to, the following: the uncertainties inherent in the initiation, completion and cost of clinical trials including proof of concept trials, including the uncertain outcomes, the availability and timing of data from ongoing and future clinical trials and the results of such trials, whether preliminary results from a particular clinical trial will be predictive of the final results of that trial or whether results of early clinical trials will be indicative of the results of later clinical trials, the unproven approach of the companys ImmTOR technology, potential delays in enrollment of patients, undesirable side effects of the companys product candidates, its reliance on third parties to manufacture its product candidates and to conduct its clinical trials, the companys inability to maintain its existing or future collaborations, licenses or contractual relationships, its inability to protect its proprietary technology and intellectual property, potential delays in regulatory approvals, the availability of funding sufficient for its foreseeable and unforeseeable operating expenses and capital expenditure requirements, the companys recurring losses from operations and negative cash flows from operations raise substantial doubt regarding its ability to continue as a going concern, substantial fluctuation in the price of its common stock, and other important factors discussed in the Risk Factors section of the companys most recent Quarterly Report on Form 10-Q, and in other filings that the company makes with the Securities and Exchange Commission. In addition, any forward-looking statements included in this press release represent the companys views only as of the date of its publication and should not be relied upon as representing its views as of any subsequent date. The company specifically disclaims any intention to update any forward-looking statements included in this press release.

AskBio Forward-Looking StatementsThis press release contains forward-looking statements regarding AskBio. Any statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. Words such as believes, anticipates, plans, expects, will, intends, potential, possible and similar expressions are intended to identify forward-looking statements. These forward-looking statements include statements regarding MMA-101, including the potential timing of the Phase 1 clinical trial for patients with MMA, AskBios pipeline of development candidates; AskBios goal of developing life-saving medicines aimed at curing genetic diseases; the potential benefits of AskBios development candidates to patients.

These forward-looking statements involve risks and uncertainties, many of which are beyond AskBios control. Known risks include, among others: AskBio may not be able to execute on its business plans and goals, including meeting its expected or planned regulatory milestones and timelines, clinical development plans and bringing its product candidates to market, due to a variety of reasons, including the ongoing COVID-19 pandemic, possible limitations of company financial and other resources, manufacturing limitations that may not be anticipated or resolved in a timely manner, potential disagreements or other issues with our third-party collaborators and partners, and regulatory, court or agency feedback or decisions, such as feedback and decisions from the United States Food and Drug Administration or the United States Patent and Trademark Office.

Any of the foregoing risks could materially and adversely affect AskBios business and results of operations. You should not place undue reliance on the forward-looking statements contained in this press release. AskBio does not undertake any obligation to publicly update its forward-looking statements based on events or circumstances after the date hereof.

For more information please contact:

Selecta: For Investors:Lee M. SternSolebury Trout+1-646-378-2922lstern@soleburytrout.com

For Media: Meredith Sosulski, Ph.D.LifeSci Communications, LLC+1-929-469-3851msosulski@lifescicomms.com

AskBio:Robin FastenauVice President, Communications+1-984-275-2705rfastenau@askbio.com

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Selecta Biosciences and AskBio Receive FDA Rare Pediatric Disease Designation for their Gene Therapy for Methylmalonic Acidemia - GlobeNewswire

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Pfizer: Expanding North Carolina Gene Therapy Facility and Adding Jobs – BioSpace

October 25th, 2020 5:58 am

In anticipation of our Pfizer Gene Therapy Career Event scheduled for Wednesday, October 28, 2020, BioSpace spoke with Alison Ricci, Pfizers Senior Business HR Partner- Global Sciences, Business HR for Bioprocess Research and Development, and HR Site Lead for the companys four locations in Chapel Hill and Morrisville, North Carolina, Chesterfield, Missouri and Lake Forest, Illinois.

In late August, Pfizer announced it was investing an additional $500 million into its state-of-the-art gene therapy manufacturing facility in Sanford, North Carolina. This is in addition to the companys continuing investment into gene therapy research and development and other areas going on throughout the company, but specifically in its North Carolina sites in Chapel Hill and Kit Creek. The companys presence in North Carolina currently exceeds 3,600 people, with 650 in Sanford. The expanded facility is expected to add over 100 new jobs.

Ricci told BioSpace the company has been investing heavily in gene therapy and in the Raleigh-Durham Research Triangle Park area. They have three facilities in and around the area that focus specifically on gene therapy, including a research facility in Morrisville, its existing clinical manufacturing site in Chapel Hill, and a very large manufacturing site in Sanford.

And in recognition of the continued investment and commitment to gene therapy, the company acquired a 60,000-square-feet building and 16 acres in Durham, which they are renovating into a clinical manufacturing site, essentially doubling our clinical manufacturing capacity.

*Rendering of Durham location

As such, the company has numerous positions in the area currently open with many more expected as the new site comes online.

Right now, we have 30 positions that were going to be advertising for that directly support gene therapy in those three different campuses, Ricci said.

The roles they will be looking to fill include what Ricci calls a multitude of individual contributor, team lead and management roles."

"For instance, weve got our R&D and analytical scientist roles; we have manufacturing engineering roles; we have technical specialist roles; and different types of manufacturing support and technology transfer roles, Ricci said.

They also have training specialist positions because there are a variety of supporting functions that go into the magic of making gene therapy work.

Ricci seemed excited about gene therapy and the part it is playing increasingly in Pfizers core mission. Speaking of Duchenne muscular dystrophy (DMD), increasingly a target of gene therapies, she noted how exciting and important it is to be able to provide a therapy that extends quality of life, that doesnt just treat symptoms, but that potentially marks a minimization of those symptoms and the elongation of life. Thats one of the central core components of who Pfizer is. Our patients are our North Star.

She also emphasized not only the science and motivation of Pfizer as an employer, but its culture.

People typically equate large organizations with a level of bureaucracy, that results in less risk and less innovation opportunities, Ricci said. In my five years with Pfizer Ive seen the culture shift to focus on innovation, inclusion, quality and smart resourcing figuring out how to free up resources so we can focus on bold moves and exciting new therapies allowing our scientists to stretch and grow, and make a difference for the patients that count on us.

The company has also structured rewards and recognition around those types of approaches, not only for people theyre bringing into the organization, but with its current staff.

Were still maintaining our focus on a combination of productivity and doing it right the first time while encouraging innovation, taking bold moves and trying new things," Ricci said. "Because thats the best way that good science is done, and patients win in the process.

She also notes that the Pfizer Gene Therapy Career Event is a great opportunity to have direct contact not only with Pfizer hiring managers, but with colleagues who are working in those same roles theyre hiring for.

Its a unique experience in terms of really understanding who Pfizer is and what we have to offer, Ricci said.

And, of course, the company is hiring throughout its worldwide operations in support of not only its COVID-19 clinical research trials and manufacturing processes, but in the numerous other areas the company focuses on.

The expansion in Sanford, North Carolina is only a part of the companys focus on building out capacity. It has committed about $5 billion in U.S.-based capital projects over the next several years.

But the North Carolina area is expanding end-to-end capabilities in gene therapy. The Kit Creek facility focuses on small scale production, from 2L flasks up to 250L bioreactors to develop the early processes that will later be used in larger scale manufacturing. The Chapel Hill facility is where the process is optimized, and staffers work at a 250L scale while developing and implementing quality control measures that include Good Manufacturing Practice (GMP) standards. The Sanford facility is designed for high-quality, efficient supply of gene therapies at clinical- and commercial-scale.

Ricci also points to Paul Mensah, Pfizers Vice President of Bioprocess Research and Development.

He has a nice, pragmatic style and approach in terms of how he continues to foster and leverage innovation, but also the science of how everyone works together to collaborate and deliver. He instills that in the leaders on the team. Ricci said.

Were continuing to focus in terms of career development and the aspirations of each colleague. There are opportunities for colleagues at Pfizer to do anything they want within the realms of the organization." Ricci said. "You can be on the frontlines of early stage development, you can work on the late stage, you can have opportunities for clinical manufacturing. You can run the gamut in terms of different roles with the scientific profile within Pfizer.

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Pfizer: Expanding North Carolina Gene Therapy Facility and Adding Jobs - BioSpace

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UCI-led study reveals significant restoration of retinal and visual function following gene therapy – UCI News

October 25th, 2020 5:58 am

Irvine, Calif., October 19, 2020 A breakthrough study, led by researchers from the University of California, Irvine, results in the restoration of retinal and visual functions of mice models suffering from inherited retinal disease.

Published today in Nature Biomedical Engineering, the paper, titled, Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing, illustrates the use of a new generation CRISPR technology and lays the foundation for the development of a new therapeutic modality for a wide range of inherited ocular diseases caused by different gene mutations.

In this proof-of-concept study, we provide evidence of the clinical potential of base editors for the correction of mutations causing inherited retinal diseases and for restoring visual function, said Krzysztof Palczewski, PhD, the Irving H. Leopold chair and a distinguished professor in the Gavin Herbert Eye Institute, Department of Ophthalmology at the UCI School of Medicine. Our results demonstrate the most successful rescue of blindness to date using genome editing.

Inherited retinal diseases (IRDs) are a group of blinding conditions caused by mutations in more than 250 different genes. Previously, there was no avenue available for treating these devastating blinding diseases. Recently, the FDA approved the first gene augmentation therapy for Leber congenital amaurosis (LCA), a common form of IRD which originates during childhood.

As an alternative to gene augmentation therapy, we applied a new generation of CRISPR technology, referred to as base editing as a treatment for inherited retinal diseases, said first author Susie Suh, assistant specialist in the UCI School of Medicine Department of Ophthalmology. We overcame some of the barriers to the CRISPR-Cas9 system, such as unpredictable off-target mutations and low editing efficiency, by utilizing cytosine and adenine base editors (CBE and ABE). Use of these editors enabled us to correct point mutations in a precise and predictable manner while minimizing unintended mutations that could potentially cause undesirable side effects, said co-first author Elliot Choi, also an assistant specialist in the UCI Department of Ophthalmology.

Using an LCA mouse model harboring a clinically relevant pathogenic mutation in the Rpe65 gene, the UCI team successfully demonstrated the therapeutic potential of base editing for the treatment of LCA and by extension other inherited blinding diseases. Among other results, the base editing treatment restored retinal and visual function in LCA mice to near-normal levels. Base editing was developed at the Broad Institute of MIT and Harvard in the lab of David Liu, PhD.

After receiving treatment, the mice in our study could discriminate visual changes in terms of direction, size, contrast and spatial and temporal frequency, said Palczewski. These results are extremely encouraging and represent a major advance towards the development of treatments for inherited retinal diseases.

Gene therapy approaches to treating inherited retinal diseases are of special interest given the accessibility of the eye, its immune-privileged status and the successful clinical trials of RPE65 gene augmentation therapy that led to the first US Food and Drug Administration-approved gene therapy. Now, as demonstrated in this study, base-editing technology can provide an alternative treatment model of gene augmentation therapy to permanently rescue the function of a key vision-related protein disabled by mutations.

This research was supported in part by grants from the National Institutes of Health, the Research to Prevent Blindness Stein Innovation Award, Fight for Sight, the Eye and Tissue Bank Foundation (Finland), The Finnish Cultural Foundation, the Orion Research Foundation, the Helen Hay Whitney Foundation, US Department of Veterans Affairs, and a Research to Prevent Blindness unrestricted grant to the Department of Ophthalmology, University of California, Irvine.

About the University of California, Irvine: Founded in 1965, UCI is the youngest member of the prestigious Association of American Universities. The campus has produced three Nobel laureates and is known for its academic achievement, premier research, innovation and anteater mascot. Led by Chancellor Howard Gillman, UCI has more than 36,000 students and offers 222 degree programs. Its located in one of the worlds safest and most economically vibrant communities and is Orange Countys second-largest employer, contributing $5 billion annually to the local economy. For more on UCI, visit http://www.uci.edu.

Media access: Radio programs/stations may, for a fee, use an on-campus ISDN line to interview UCI faculty and experts, subject to availability and university approval. For more UCI news, visit news.uci.edu. Additional resources for journalists may be found at communications.uci.edu/for-journalists.

About the UCI School of Medicine: Each year, the UCI School of Medicine educates more than 400 medical students, and nearly 150 doctoral and masters students. More than 700 residents and fellows are trained at UCI Medical Center and affiliated institutions. The School of Medicine offers an MD; a dual MD/PhD medical scientist training program; and PhDs and masters degrees in anatomy and neurobiology, biomedical sciences, genetic counseling, epidemiology, environmental health sciences, pathology, pharmacology, physiology and biophysics, and translational sciences. Medical students also may pursue an MD/MBA, an MD/masters in public health, or an MD/masters degree through one of three mission-based programs: the Health Education to Advance Leaders in Integrative Medicine (HEAL-IM), the Leadership Education to Advance Diversity-African, Black and Caribbean (LEAD-ABC), and the Program in Medical Education for the Latino Community (PRIME-LC). The UCI School of Medicine is accredited by the Liaison Committee on Medical Accreditation and ranks among the top 50 nationwide for research. For more information, visit som.uci.edu.

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CEO Dr. Shankar Musunuri to Discuss the Importance of Gene Therapy Strategic Partnerships at 4th Annual Gene Therapy for Rare Disorders Europe…

October 25th, 2020 5:58 am

MALVERN, Pa., Oct. 22, 2020 (GLOBE NEWSWIRE) -- Ocugen, Inc. (NASDAQ: OCGN), a biopharmaceutical company focused on discovering, developing, and commercializing transformative therapies to cure blindness diseases, today announced Dr. Shankar Musunuri, Chairman, CEO, and Co-Founder of Ocugen, will speak on the importance of strategic partnerships in gene therapy including product consistency, identifying the right partner as well as providing examples of successful partnerships at the 4th Annual Gene Therapy for Rare Disorders Europe Conference from October 26-28, 2020 presented digitally.

Presentation Details:Title:The Importance of Strategic Partnerships in Gene TherapyDate: Wednesday, October 28, 2020Time: 11:00 AM (GMT)Location: DigitalRegister: https://genetherapy-europe.com/take-part/register/

About Ocugen, Inc.Ocugen, Inc. is a biopharmaceutical company focused on discovering, developing, and commercializing transformative therapies to cure blindness diseases. Our breakthrough modifier gene therapy platform has the potential to treat multiple retinal diseases with one drug one to many and our novel biologic product candidate aims to offer better therapy to patients with underserved diseases such as wet age-related macular degeneration, diabetic macular edema, and diabetic retinopathy. For more information, please visit http://www.ocugen.com.

Cautionary Note on Forward-Looking StatementsThis press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995, which are subject to risks and uncertainties. We may, in some cases, use terms such as predicts, believes, potential, proposed, continue, estimates, anticipates, expects, plans, intends, may, could, might, will, should or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Such statements are subject to numerous important factors, risks and uncertainties that may cause actual events or results to differ materially from our current expectations. These and other risks and uncertainties are more fully described in our periodic filings with the Securities and Exchange Commission (the SEC), including the risk factors described in the section entitled Risk Factors in the quarterly and annual reports that we file with the SEC. Any forward-looking statements that we make in this press release speak only as of the date of this press release. Except as required by law, we assume no obligation to update forward-looking statements contained in this press release whether as a result of new information, future events or otherwise, after the date of this press release.

Corporate Contact:Ocugen, Inc.Sanjay SubramanianChief Financial OfficerIR@Ocugen.com

Media Contact: LaVoieHealthScience Katie Gallagherkgallagher@lavoiehealthscience.com+1 617-792-3937

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CEO Dr. Shankar Musunuri to Discuss the Importance of Gene Therapy Strategic Partnerships at 4th Annual Gene Therapy for Rare Disorders Europe...

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8-Year-old Sees Stars for the First Time After His Blindness is Treated With Gene Therapy – Good News Network

October 25th, 2020 5:58 am

Wishing on a star is one of the most magical rites of childhood:

Star light, star bright,The first star I see tonightI wish I may, I wish I might,Have the wish I wish tonight.

But for one little Canadian boy named Sam, that simple activity was beyond his reach. Thats because 8-year-old Sam couldnt see the stars.

Sam suffers from the rare disorder retinitis pigmentosa, a form of progressive blindness caused by genetic retinal degeneration that results from mutations in the RPE65 gene.

You lose perception of light, Dr. Elise Heon, of Sick Kids Hospital, explained to CTV News. You end up in darkness and [its] slowly progressive, its relentless, your visual field shrinks and shrinks and shrinks and shrinks.

Sams sight was extremely limited, especially at night. Images most people take for grantedthe stars, an airplane streaking across the sky, or even our own shoeswere beyond the scope of his vision. Until recently, there was no effective treatment for his condition.

RELATED:Scientists Use New Holy Grail Gene Therapy to Heal Damage Caused By Heart Attacks and it Could Save Millions

Now, however, thanks to a new form of gene therapy, many patients, including Sam, are seeing huge improvements in their eyesight. The science behind the protocol is impressive.

After being modified with a healthy copy of the gene, an inactivated virus is injected directly into the retina. (Each eye is injected only once.) The healthy gene then goes to work, enabling cells to produce a protein that converts light into electrical signals, which in turn, facilitates improved vision and prevents further progression of the disease.

The targeted gene therapy protocol, developed in the U.S., was recently green-lit for use in Canada, but with Sams sight failing, he and his mom, Sarah Banon, traveled to America last year to get him treatment.

Within a weeks time, Banon began to notice progress and says Sams condition has continued to improve over the course of the year since he underwent the procedure.

She reports her son has gained incredible confidence. He dresses without help. Hes able to see, even when its dark, and he no longer requires lights on when its cloudy outside.

MORE: In World First, Gene Therapy Trial Restores Vision in Patients With Genetic Form of Blindness

Now he is able to function as a normal child, she told CTV. This is a story of hope A child told it is what it is, and now, when he looks up at night, he can see stars.

And when Sam wishes on those stars, hell know in his heart that sometimes, wishes really can come true.

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AGTC to Participate in Cantor Fitzgerald Virtual Panel: Key Considerations for Gene Therapy Manufacturing and Platforms – GlobeNewswire

October 25th, 2020 5:58 am

GAINESVILLE, Fla., and CAMBRIDGE, Mass., Oct. 21, 2020 (GLOBE NEWSWIRE) -- Applied Genetic Technologies Corporation (Nasdaq: AGTC), a biotechnology company focused on developing adeno-associated virus (AAV) based gene therapies for the treatment of rare inherited diseases, today announced that Sue Washer, President & Chief Executive Officer, and Dave Knop, PhD, Vice President, Process Development and Manufacturing, will participate in the Cantor Fitzgerald Key Considerations for Gene Therapy Manufacturing and Platforms virtual panel at 10:00 a.m. ET on Wednesday, October 28, 2020.

The panel will focus on the critical components and capabilities to gene therapy manufacturing, including a discussion on AGTCs proprietary manufacturing processes associated with AAV, and key company catalysts expected over the next 12 months. The call will be moderated by Kristen Kluska, Biotechnology Research Analyst of Cantor Fitzgerald.

Presentation Information:Panel: Key Considerations for Gene Therapy Manufacturing and PlatformsDate: Wednesday, October 28, 2020Time: 10:00 a.m. 11:30 a.m. ET

To register for the event, please click here.

About AGTCAGTC is a clinical-stage biotechnology company developing genetic therapies for people with rare and debilitating ophthalmic, otologic and central nervous system (CNS) diseases. AGTC is a leader in designing and constructing all critical gene therapy elements and bringing them together to develop customized therapies that address real patient needs. The Companys most advanced clinical programs leverage its best-in-class technology platform to potentially improve vision for patients with an inherited retinal disease. AGTC has active clinical trials in X-linked retinitis pigmentosa and achromatopsia (ACHM CNGB3 & ACHM CNGA3). Its pre-clinical programs build on the Companys industry leading AAV manufacturing technology and scientific expertise. AGTC is advancing multiple important pipeline candidates to address substantial unmet clinical need in optogenetics, otology and CNS disorders.

IR/PR CONTACTS:David Carey (IR) or Glenn Silver (PR)Lazar FINN PartnersT: (212) 867-1768 or (646) 871-8485david.carey@finnpartners.com or glenn.silver@finnpartners.com

Corporate Contact:Bill SullivanChief Financial OfficerApplied Genetic Technologies CorporationT: (617) 843-5728bsullivan@agtc.com

Stephen PotterChief Business OfficerApplied Genetic Technologies CorporationT: (617) 413-2754spotter@agtc.com

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AGTC to Participate in Cantor Fitzgerald Virtual Panel: Key Considerations for Gene Therapy Manufacturing and Platforms - GlobeNewswire

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Bo Cumbo jumps from the top commercial post at Sarepta to the helm of a gene therapy startup with some influential backers, big plans and $107M -…

October 25th, 2020 5:58 am

Setting the stage for an extraordinary one-day meeting of the Vaccines and Related Biological Products Advisory Committee this Thursday, the FDA has cleared 2 experts of financial conflicts to help beef up the committee. And regulators went on to specify the safety, efficacy and CMC input theyre looking for on EUAs, before they move on to the full BLA approval process.

All of this has already been spelled out to the developers. But the devil is in the details, and its clear from the first round of posted responses that some of the top players including J&J and Pfizer would like some adjustments and added feedback. And on Thursday, the experts can offer their own thoughts on shaping the first OKs.

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Gene therapy to restore vision in mice – News Landed

October 25th, 2020 5:58 am

Blindness is a global problem where a person cannot see anything, including light. Researchers find novel ways like gene therapy to impart vision, and they initially experimented with mice. They claimed to restore vision in totally blind mice with the help of gene therapy.

Opsins are a group of proteins, that is light sensitive through the presence of chromophore retinal found in the photoreceptor cells of the retina. These opsins only covalently bind to vitamin-A based retinaldehyde in both rods and cones. This starts a cascade of signals when the light activates the photoreceptor cells in the retina. This causes pulsations, which propagates by creating an impulse through the optic nerve to the brain.

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Several disease conditions like macula degeneration, retinitis pigmentosa were causing damage to the photoreceptor cells, which in turn leading to blindness.

Read Also: The water industry can be made more sustainable by a better understanding of biofilms

Scientists said that they can still restore vision even if the photoreceptor cells are impaired. This is by a group of neurons, which we say bipolar cells, can help to evade blindness. When photoreceptor cells failed, other neuronal cells would remain intact.

This is possible when we insert the MCO1 opsin gene to the intact bipolar cells in the retina, which is downstream to the photoreceptors. Hence, the ability to see objects or light enhances.

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This gene therapy could overcome other treatments such as replacement of opsin, invasive surgery, and all that. Also, this treatment is effective in causing 20/60 vision in patients. Clinical trials are necessary to depict a clear picture of showing how it works when it comes to fast-moving objects, and whether it affects vision quality.

Experiments with mice did not yield any harmful effects upon the administration of genes. If everything goes well, they can successfully implement the treatment, and it will definitely be an alternative to the retinal prosthesis such as retinitis pigmentosa.

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Source: Medical Xpress

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Premium Insights of Gene Therapy Market Size-Share Analysis and System Production (2020-2026) | Addressing the Potential Impact of COVID-19 by ZMR -…

October 25th, 2020 5:58 am

According to the report the Zion Market Research Reports Premium Insights of Gene Therapy Market Size-Share Analysis and System Production (2020-2026) | Addressing the Potential Impact of COVID-19 by ZMR. The global Gene Therapy Market report offers an in-depth analysis of the Gene Therapy Market. It presents a succinct outline of theGene Therapy Marketand explains the major key elements of the market. Additionally, the report highlights significant players in the global Gene Therapy Market along with their investment in the market to assess their growth during the estimated time. The foremost market players in the industry are also included in this report for a better understanding of business strategies, growth analysis, sales and revenue and growth factors. The report discusses the most recent expansions while predicting the development of the key players in the near future.

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The Gene Therapy Market is growing at a rapid pace and with the rise in technological innovation, competition and M&A activities in the industry. Further, the research report is segmented on the basis of Application & Other with historical and projected market share and compounded annual growth rate (CAGR). In addition, the research provides key market features, revenue, capacity, capacity, price, growth rate, consumption, production, supply & demand, market share, and CAGR. The report offers a wide-ranging study of imperative market dynamics and their latest trends, coupled with pertinent market segments.

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Cardiac Autonomic Neuropathy Treatment Market: Expansion Strategies Set to Generate Substantial Revenue in the near Future – Eurowire

October 25th, 2020 5:57 am

The latest published an effective statistical data titled as Cardiac Autonomic Neuropathy Treatment Market. It defines about the recent innovations, applications and end users of the market. It covers the different aspects, which are responsible for the growth of the industries. Different domains are considered on the basis of the capital of Cardiac Autonomic Neuropathy Treatment market. The analyst examines different companies on the basis of their productivity to review the current strategies. All leading players across the globe, are profiled with different terms, such as product types, industry outlines, sales and much more.

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The study throws light on the recent trends, technologies, methodologies, and tools, which can boost the performance of companies. For further market investment, it gives the depth knowledge of different market segments, which helps to tackle the issues in businesses. It includes effective predictions about the growth factors and restraining factors that can help to enlarge the businesses by finding issues and acquire more outcomes. Leading market players and manufacturers are studied to give a brief idea about competitions. To make well-informed decisions in Cardiac Autonomic Neuropathy Treatment areas, it gives the accurate statistical data.

The analyst also focuses on economic and environmental factors, which impacts on the growth of the businesses. For global analysis, the market is examined by considering the different regions such as North America, Latin America, Japan, China, and India. Leading companies are focusing on spreading their products across the regions. Research and development activities of the various industries are included in the report, to decide the flow of the market.

segment by Type, the product can be split intoSolid OralInjectable

Market segment by Application, split intoHospitalsCardiac CentersAmbulatory Surgical Centers

Based on regional and country-level analysis, the Cardiac Autonomic Neuropathy Treatment market has been segmented as follows:North AmericaUnited StatesCanadaEuropeGermanyFranceU.K.ItalyRussiaNordicRest of EuropeAsia-PacificChinaJapanSouth KoreaSoutheast AsiaIndiaAustraliaRest of Asia-PacificLatin AmericaMexicoBrazilMiddle East & AfricaTurkeySaudi ArabiaUAERest of Middle East & Africa

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Competition Analysis

This report examines the ups and downs of the leading key players, which helps to maintain proper balance in the framework. Different global regions, such as Germany, South Africa, Asia Pacific, Japan, and China are analyzed for the study of productivity along with its scope. Moreover, this report marks the factors, which are responsible to increase the patrons at domestic as well as global level.

In the competitive analysis section of the report, leading as well as prominent players of the global Cardiac Autonomic Neuropathy Treatment market are broadly studied on the basis of key factors. The report offers comprehensive analysis and accurate statistics on revenue by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on price and revenue (global level) by player for the period 2015-2020.The key players covered in this studyPfizerRoche HoldingNovartisAmgenPrivi PharmaSilverline ChemicalsAnthem BiopharmaPraxis Pharmaceutical

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Chapter 1 Introduction and Overview

Chapter 2 Industry Cost Structure and Economic Impact

Chapter 3 Rising Trends and New Technologies with Major key players

Chapter 4 Global Cardiac Autonomic Neuropathy Treatment Market Analysis, Trends, Growth Factor

Chapter 5 Cardiac Autonomic Neuropathy Treatment Market Application and Business with Potential Analysis

Chapter 6 Global Cardiac Autonomic Neuropathy Treatment Market Segment, Type, Application

Chapter 7 Global Cardiac Autonomic Neuropathy Treatment Market Analysis (by Application, Type, End User)

Chapter 8 Major Key Vendors Analysis of Cardiac Autonomic Neuropathy Treatment Market

Chapter 9 Development Trend of Analysis

Chapter 10 Conclusion

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Cardiac Autonomic Neuropathy Treatment Market: Expansion Strategies Set to Generate Substantial Revenue in the near Future - Eurowire

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Chemotherapy Induced Peripheral Neuropathy Treatment Market to Increase Exponentially During 2020 2027 – Eurowire

October 25th, 2020 5:57 am

Latest added Global Chemotherapy Induced Peripheral Neuropathy Treatment Market research study offers detailed product outlook and elaborates market review till 2025. The market Study is segmented by key regions that is accelerating the marketization. The study is a perfect mix of qualitative and quantitative Market data collected and validated majorly through primary data and secondary sources.

This report studies the Global Chemotherapy Induced Peripheral Neuropathy Treatment market size, industry status and forecast, competition landscape and growth opportunity. This research report categorizes the Global Chemotherapy Induced Peripheral Neuropathy Treatment market by companies, region, type and end-use industry.

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to Avail deep insights of Global Chemotherapy Induced Peripheral Neuropathy Treatment Market Size, competition landscape is provided i.e. Revenue Analysis (M $US) by Company (2017-2019), Segment Revenue Market Share (%) by Players (2017-2019) and further a qualitative analysis is made towards market concentration rate, product/service differences, new entrants and the technological trends in future.

Competitive Analysis:

The major players are focusing highly on innovation in technologies to improving efficiency level. The industry growth outlook is captured by ensuring ongoing process improvements of players and optimal strategies taken up by companies to fight COVID-19 Situation.

The following players are covered in this report:

Aptinyx Inc

Asahi Kasei Pharma Corp

Regenacy Pharmaceuticals

MAKScientific LLC

Metys Pharmaceuticals AG

Nemus Bioscience Inc

PledPharma

Sova Pharmaceuticals Inc

DermaXon LLC

Kineta Inc

Krenitsky Pharmaceuticals Inc

PeriphaGen

Apexian Pharma

WinSanTor

Solasia Pharma K.K.

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Market Segments: The Global Chemotherapy Induced Peripheral Neuropathy Treatment Market has been divided into type, application, and region.

Breakdown Data by Type

Calcium Channel 2-delta Ligands

Antidepressants

Opioids

Others

Chemotherapy Induced Peripheral Neuropathy Treatment Breakdown Data by Application

Platinum Agents

Taxanes

Vinca Alkaloids

Others

Based on regional and country-level analysis, the Chemotherapy Induced Peripheral Neuropathy Treatment market has been segmented as follows:

North America

United States

Canada

Europe

Germany

France

U.K.

Italy

Russia

Nordic

Rest of Europe

Asia-Pacific

China

Japan

South Korea

Southeast Asia

India

Australia

Rest of Asia-Pacific

Latin America

Mexico

Brazil

Middle East & Africa

Turkey

Saudi Arabia

UAE

Rest of Middle East & Africa

On The basis of region, the Chemotherapy Induced Peripheral Neuropathy Treatment is segmented into countries, with production, consumption, revenue (million USD), and market share and growth rate in these regions, from 2014 to 2025 (forecast), see highlights below

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We analysts identify in broad terms why some companies are gaining or losing share within a given market segment. Every company have its own story and changes in market share are knowingly the most important indicator of management effectiveness & corporate strategies; it is important to identify those who are succeeding in the market and those who are failing, and the cause of the market flux. Key Financial Ratios are also considered to get towards root-cause analysis of each companies such as Return on Assets, ROCE, and Return on Equity etc. From this understanding of the forces driving the market, the analyst team prepares its strategic recommendations. Ultimately, its that market wisdom, beyond the market data and forecasts, which is the most valuable component of market research studies and provides our clientele with the greatest competitive edge with top level quality standards.

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Chemotherapy Induced Peripheral Neuropathy Treatment Market to Increase Exponentially During 2020 2027 - Eurowire

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5 Reasons Rehabilitation Care is Important After Breast Cancer – University of Michigan Health System News

October 25th, 2020 5:57 am

Many patients think of cancer care as chemotherapy or surgery to remove a tumor or mass. But, there is one important treatment that is often overlooked: rehabilitation.

Breast cancer, in particular, can leave many patients with painful symptoms and side effects that rehabilitation could help ease.

Weve noticed that many patients with breast cancer have greatly benefited from the rehabilitation care we can provide, says Sean Smith, M.D., an associate professor of physical medicine and rehabilitation at Michigan Medicine and medical director of the Cancer Rehabilitation Program at the University of Michigan Rogel Cancer Center.

The Cancer Rehabilitation Program offers patients, with any type of cancer, at any point in treatment, comprehensive rehabilitation services and care.

One of our most robust programs for patients with breast cancer is the lymphedema program, which involves hands-on therapy by specialty-trained occupational therapists, Smith says. But, we also see a lot of patients greatly improve from symptoms such as pain in the shoulder and chest, and stiffness from aromatase inhibitors, or medications that stop the production of estrogen in postmenopausal women.

Smith says many patients with breast cancer often dont realize rehabilitation care is available for them, and that its performed by experts specifically trained to help the patient group.

The expertise for rehabilitating cancer patients at Michigan Medicine is matched by few institutions, he says. Patients coming here can be sure that they will receive a thorough, detailed and individualized approach to their care by people who understand the complicated and difficult medical treatment they have received.

Here, Smith highlights five reasons why rehabilitation care is important for patients with breast cancer.

1. Rehabilitation care helps to treat the physical and mental side effects of cancer.

Smith says the most common reason for rehabilitation care in patients with breast cancer is chest or shoulder issues after surgery and radiation. This can include pain, tightness, numbness and more.

We also diagnose and treat problems related to chemotherapy, including neuropathy or cognitive issues, aromatase inhibitors, such as stiffness, pain and trigger finger, and the disease itself, such as back pain and cognitive issues with metastatic disease, he says.

The team helps with both the physical aspects of rehabilitation, such as a patient needing supportive braces or having a tough time reaching overhead due to tightness from radiation therapy, as well as the cognitive side effects of cancer treatment.

We help patients that have neuropathy from chemotherapy and we provide options for treatment including balance therapy, Smith says. We also help treat chemobrain, or what patients often describe as a mental cloudiness or cognitive impairment from chemotherapy.

2. Cancer rehabilitation care is specialized to the patients specific needs.

The Cancer Rehabilitation Program practices what they call impairment-driven cancer rehabilitation.

Thats a complicated way of saying we treat whatever problem a patient describes, Smith says. For example, if a patient wants to be able to throw a ball with her grandchild, we work on that. Our program is always 100% patient-centered and individualized to their needs.

Smith says the cancer rehabilitation team includes physicians, physical and occupational therapists, psychologists and additional experts, to address whichever needs a patient is experiencing.

The physicians are cancer rehabilitation physicians, which means that they sub-specialize in treating neurologic, musculoskeletal and cognitive problems that patients experience due to cancer treatment, he says. Our therapists often receive additional certifications to be able to best treat cancer-related issues, including lymphedema, radiation fibrosis and more.

3. Rehabilitation care benefits patients at any point along their cancer treatment timeline.

Whether a patient is currently going through breast cancer treatment, or is in remission, the cancer rehabilitation team is ready to help.

We treat patients all along the cancer treatment timeline from those newly diagnosed, to those who have been free of disease for decades, to those with metastatic disease, Smith says. Before we meet a patient, we conduct a thorough review of their cancer treatment history so that we are prepared to make a plan after talking with the patient.

4. Patients dont need a referral to see a rehabilitation specialist.

Making an appointment with a cancer rehabilitation specialist at Michigan Medicine can be done a couple of ways.

Often times, patients are referred by one of their oncology providers to see either a physician, therapist or psychologist, Smith says. Of course we also have patients call for an appointment without a referral, which is great, too.

He notes that once a patient sees one member of the team, they are sometimes referred to another provider if it would help in their overall treatment.

A physician might refer a patient for lymphedema therapy, or a therapist may suggest a referral to a psychologist if the patient is struggling with cognitive issues, Smith says.

5. Adding rehabilitation care to cancer treatment can benefit a patients quality of life.

Patients who are treated for cancer often are assumed to be back to normal when their treatment ends, but Michigan Medicine and the U-M Rogel Cancer Center recognize that is not the case, Smith says. Its not uncommon for patients to be dealing with the after effects of cancer treatment long after treatment ends.

The rehabilitation team of experts can help restore a patients quality of life, no matter what type of cancer they are experiencing. Smith says the goal is always to get the patient back to doing what they enjoy, whether that be spending time with their family, returning to work or keeping up with their hobbies.

He adds, Patients with breast cancer, or any form of cancer, don't have to endure these issues, but they often don't know how to get help or the amount of help that is available to them. They can take the first step by contacting our team, or asking their doctor for a referral. We would love to meet with them and develop a plan to help them recover from cancer-related symptoms.

Learn more about the Cancer Rehabilitation Program and schedule an appointment.

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5 Reasons Rehabilitation Care is Important After Breast Cancer - University of Michigan Health System News

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Diabetes mellitus in an adolescent girl with intellectual disability caused by novel single base pair duplication in the PTRH2 gene: Expanding the…

October 25th, 2020 5:57 am

This article was originally published here

Brain Dev. 2020 Oct 19:S0387-7604(20)30272-2. doi: 10.1016/j.braindev.2020.09.009. Online ahead of print.

ABSTRACT

BACKGROUND: Infantile-onset multisystem neurologic, endocrine, and pancreatic disease (IMNEPD) is an extremely rare autosomal recessive disorder with variable expressivity, caused by biallelic mutations in the PTRH2 gene. Core features are global developmental delay or isolated speech delay, intellectual disability, sensorineural hearing loss, ataxia, and pancreatic insufficiency (both exocrine and endocrine). Additional features may include postnatal microcephaly, peripheral neuropathy, facial dysmorphism, and cerebellar atrophy. In literature, there are only a few anecdotal case reports and none of the previous cases presented with diabetic ketoacidosis.

METHODS: We are reporting a 12-year old adolescent girl with mild intellectual disability who presented with fever, pain abdomen for 2 days, and fast breathing for one day.

RESULTS: Her random blood sugar was 472 mg/dl and arterial blood gas revealed high anion gap metabolic acidosis. Urine examination showed ketonuria. On further evaluation, she was found to have demyelinating sensorimotor polyneuropathy and sensorineural hearing loss. Neuroimaging and other ancillary investigations were normal. Whole exome sequencing revealed a novel homozygous single base pair duplication in exon 1 of the PTRH2 gene (c.127dupA, p.Ser43LysfsTer11), confirming the diagnosis of IMNEPD.

CONCLUSIONS: Apart from describing a novel single base pair duplication causing protein truncation in the PTRH2 gene for the first time, our case also expanded the clinical spectrum of IMNEPD, as this is the first case with seemingly pure neurodevelopmental phenotype, who later developed diabetes mellitus, without any exocrine pancreatic abnormality. IMNEPD should be considered in children or adolescents with global developmental delay or intellectual disability when they develop diabetes mellitus.

PMID:33092935 | DOI:10.1016/j.braindev.2020.09.009

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Pharmaceutical and Biotechnology Environmental Monitoring Market Trend, Industry Analysis, COVID-19 Impact, Growth Rate and Future Forecast 2020-2026…

October 25th, 2020 5:56 am

LOS ANGELES, United States: QY Research has recently published a research report titled, Global Pharmaceutical and Biotechnology Environmental Monitoring Market Size, Status and Forecast 2020-2026. This report has been prepared by experienced and knowledgeable market analysts and researchers. It is a phenomenal compilation of important studies that explore the competitive landscape, segmentation, geographical expansion, and revenue, production, and consumption growth of the global Pharmaceutical and Biotechnology Environmental Monitoring market. Players can use the accurate market facts and figures and statistical studies provided in the report to understand the current and future growth of the global Pharmaceutical and Biotechnology Environmental Monitoring market.

The report includes CAGR, market shares, sales, gross margin, value, volume, and other vital market figures that give an exact picture of the growth of the global Pharmaceutical and Biotechnology Environmental Monitoring market.

Competitive Landscape

Competitor analysis is one of the best sections of the report that compares the progress of leading players based on crucial parameters, including market share, new developments, global reach, local competition, price, and production. From the nature of competition to future changes in the vendor landscape, the report provides in-depth analysis of the competition in the global Pharmaceutical and Biotechnology Environmental Monitoring market.

Key questions answered in the report:

TOC

1 Report Overview1.1 Study Scope1.2 Key Market Segments1.3 Players Covered: Ranking by Pharmaceutical and Biotechnology Environmental Monitoring Revenue1.4 Market by Type1.4.1 Global Pharmaceutical and Biotechnology Environmental Monitoring Market Size Growth Rate by Type: 2020 VS 20261.4.2 Monitoring Equipment1.4.3 Media1.4.4 Software1.4.5 Microbiology Service1.5 Market by Application1.5.1 Global Pharmaceutical and Biotechnology Environmental Monitoring Market Share by Application: 2020 VS 20261.5.2 Pharmaceutical Industrial1.5.3 Biotechnology Industrial1.5.4 Academic Institutions1.5.5 Research Institutions1.6 Study Objectives1.7 Years Considered

2 Global Growth Trends2.1 Global Pharmaceutical and Biotechnology Environmental Monitoring Market Perspective (2015-2026)2.2 Global Pharmaceutical and Biotechnology Environmental Monitoring Growth Trends by Regions2.2.1 Pharmaceutical and Biotechnology Environmental Monitoring Market Size by Regions: 2015 VS 2020 VS 20262.2.2 Pharmaceutical and Biotechnology Environmental Monitoring Historic Market Share by Regions (2015-2020)2.2.3 Pharmaceutical and Biotechnology Environmental Monitoring Forecasted Market Size by Regions (2021-2026)2.3 Industry Trends and Growth Strategy2.3.1 Market Top Trends2.3.2 Market Drivers2.3.3 Market Challenges2.3.4 Porters Five Forces Analysis2.3.5 Pharmaceutical and Biotechnology Environmental Monitoring Market Growth Strategy2.3.6 Primary Interviews with Key Pharmaceutical and Biotechnology Environmental Monitoring Players (Opinion Leaders)

3 Competition Landscape by Key Players3.1 Global Top Pharmaceutical and Biotechnology Environmental Monitoring Players by Market Size3.1.1 Global Top Pharmaceutical and Biotechnology Environmental Monitoring Players by Revenue (2015-2020)3.1.2 Global Pharmaceutical and Biotechnology Environmental Monitoring Revenue Market Share by Players (2015-2020)3.1.3 Global Pharmaceutical and Biotechnology Environmental Monitoring Market Share by Company Type (Tier 1, Tier 2 and Tier 3)3.2 Global Pharmaceutical and Biotechnology Environmental Monitoring Market Concentration Ratio3.2.1 Global Pharmaceutical and Biotechnology Environmental Monitoring Market Concentration Ratio (CR5 and HHI)3.2.2 Global Top 10 and Top 5 Companies by Pharmaceutical and Biotechnology Environmental Monitoring Revenue in 20193.3 Pharmaceutical and Biotechnology Environmental Monitoring Key Players Head office and Area Served3.4 Key Players Pharmaceutical and Biotechnology Environmental Monitoring Product Solution and Service3.5 Date of Enter into Pharmaceutical and Biotechnology Environmental Monitoring Market3.6 Mergers & Acquisitions, Expansion Plans

4 Market Size by Type (2015-2026)4.1 Global Pharmaceutical and Biotechnology Environmental Monitoring Historic Market Size by Type (2015-2020)4.2 Global Pharmaceutical and Biotechnology Environmental Monitoring Forecasted Market Size by Type (2021-2026)

5 Market Size by Application (2015-2026)5.1 Global Pharmaceutical and Biotechnology Environmental Monitoring Market Size by Application (2015-2020)5.2 Global Pharmaceutical and Biotechnology Environmental Monitoring Forecasted Market Size by Application (2021-2026)

6 North America6.1 North America Pharmaceutical and Biotechnology Environmental Monitoring Market Size (2015-2020)6.2 Pharmaceutical and Biotechnology Environmental Monitoring Key Players in North America (2019-2020)6.3 North America Pharmaceutical and Biotechnology Environmental Monitoring Market Size by Type (2015-2020)6.4 North America Pharmaceutical and Biotechnology Environmental Monitoring Market Size by Application (2015-2020)

7 Europe7.1 Europe Pharmaceutical and Biotechnology Environmental Monitoring Market Size (2015-2020)7.2 Pharmaceutical and Biotechnology Environmental Monitoring Key Players in Europe (2019-2020)7.3 Europe Pharmaceutical and Biotechnology Environmental Monitoring Market Size by Type (2015-2020)7.4 Europe Pharmaceutical and Biotechnology Environmental Monitoring Market Size by Application (2015-2020)

8 China8.1 China Pharmaceutical and Biotechnology Environmental Monitoring Market Size (2015-2020)8.2 Pharmaceutical and Biotechnology Environmental Monitoring Key Players in China (2019-2020)8.3 China Pharmaceutical and Biotechnology Environmental Monitoring Market Size by Type (2015-2020)8.4 China Pharmaceutical and Biotechnology Environmental Monitoring Market Size by Application (2015-2020)

9 Japan9.1 Japan Pharmaceutical and Biotechnology Environmental Monitoring Market Size (2015-2020)9.2 Pharmaceutical and Biotechnology Environmental Monitoring Key Players in Japan (2019-2020)9.3 Japan Pharmaceutical and Biotechnology Environmental Monitoring Market Size by Type (2015-2020)9.4 Japan Pharmaceutical and Biotechnology Environmental Monitoring Market Size by Application (2015-2020)

10 Southeast Asia10.1 Southeast Asia Pharmaceutical and Biotechnology Environmental Monitoring Market Size (2015-2020)10.2 Pharmaceutical and Biotechnology Environmental Monitoring Key Players in Southeast Asia (2019-2020)10.3 Southeast Asia Pharmaceutical and Biotechnology Environmental Monitoring Market Size by Type (2015-2020)10.4 Southeast Asia Pharmaceutical and Biotechnology Environmental Monitoring Market Size by Application (2015-2020)

11 India11.1 India Pharmaceutical and Biotechnology Environmental Monitoring Market Size (2015-2020)11.2 Pharmaceutical and Biotechnology Environmental Monitoring Key Players in India (2019-2020)11.3 India Pharmaceutical and Biotechnology Environmental Monitoring Market Size by Type (2015-2020)11.4 India Pharmaceutical and Biotechnology Environmental Monitoring Market Size by Application (2015-2020)

12 Central & South America12.1 Central & South America Pharmaceutical and Biotechnology Environmental Monitoring Market Size (2015-2020)12.2 Pharmaceutical and Biotechnology Environmental Monitoring Key Players in Central & South America (2019-2020)12.3 Central & South America Pharmaceutical and Biotechnology Environmental Monitoring Market Size by Type (2015-2020)12.4 Central & South America Pharmaceutical and Biotechnology Environmental Monitoring Market Size by Application (2015-2020)

13 Key Players Profiles13.1 Danaher Corporation13.1.1 Danaher Corporation Company Details13.1.2 Danaher Corporation Business Overview13.1.3 Danaher Corporation Pharmaceutical and Biotechnology Environmental Monitoring Introduction13.1.4 Danaher Corporation Revenue in Pharmaceutical and Biotechnology Environmental Monitoring Business (2015-2020))13.1.5 Danaher Corporation Recent Development13.2 Thermo Fisher Scientific13.2.1 Thermo Fisher Scientific Company Details13.2.2 Thermo Fisher Scientific Business Overview13.2.3 Thermo Fisher Scientific Pharmaceutical and Biotechnology Environmental Monitoring Introduction13.2.4 Thermo Fisher Scientific Revenue in Pharmaceutical and Biotechnology Environmental Monitoring Business (2015-2020)13.2.5 Thermo Fisher Scientific Recent Development13.3 Merck13.3.1 Merck Company Details13.3.2 Merck Business Overview13.3.3 Merck Pharmaceutical and Biotechnology Environmental Monitoring Introduction13.3.4 Merck Revenue in Pharmaceutical and Biotechnology Environmental Monitoring Business (2015-2020)13.3.5 Merck Recent Development13.4 Eurofins Sinensis13.4.1 Eurofins Sinensis Company Details13.4.2 Eurofins Sinensis Business Overview13.4.3 Eurofins Sinensis Pharmaceutical and Biotechnology Environmental Monitoring Introduction13.4.4 Eurofins Sinensis Revenue in Pharmaceutical and Biotechnology Environmental Monitoring Business (2015-2020)13.4.5 Eurofins Sinensis Recent Development13.5 Lonza13.5.1 Lonza Company Details13.5.2 Lonza Business Overview13.5.3 Lonza Pharmaceutical and Biotechnology Environmental Monitoring Introduction13.5.4 Lonza Revenue in Pharmaceutical and Biotechnology Environmental Monitoring Business (2015-2020)13.5.5 Lonza Recent Development13.6 Biomerieux13.6.1 Biomerieux Company Details13.6.2 Biomerieux Business Overview13.6.3 Biomerieux Pharmaceutical and Biotechnology Environmental Monitoring Introduction13.6.4 Biomerieux Revenue in Pharmaceutical and Biotechnology Environmental Monitoring Business (2015-2020)13.6.5 Biomerieux Recent Development13.7 VAI13.7.1 VAI Company Details13.7.2 VAI Business Overview13.7.3 VAI Pharmaceutical and Biotechnology Environmental Monitoring Introduction13.7.4 VAI Revenue in Pharmaceutical and Biotechnology Environmental Monitoring Business (2015-2020)13.7.5 VAI Recent Development13.8 Cosasco13.8.1 Cosasco Company Details13.8.2 Cosasco Business Overview13.8.3 Cosasco Pharmaceutical and Biotechnology Environmental Monitoring Introduction13.8.4 Cosasco Revenue in Pharmaceutical and Biotechnology Environmental Monitoring Business (2015-2020)13.8.5 Cosasco Recent Development13.9 RMONI13.9.1 RMONI Company Details13.9.2 RMONI Business Overview13.9.3 RMONI Pharmaceutical and Biotechnology Environmental Monitoring Introduction13.9.4 RMONI Revenue in Pharmaceutical and Biotechnology Environmental Monitoring Business (2015-2020)13.9.5 RMONI Recent Development13.10 Amphenol Advanced Sensors13.10.1 Amphenol Advanced Sensors Company Details13.10.2 Amphenol Advanced Sensors Business Overview13.10.3 Amphenol Advanced Sensors Pharmaceutical and Biotechnology Environmental Monitoring Introduction13.10.4 Amphenol Advanced Sensors Revenue in Pharmaceutical and Biotechnology Environmental Monitoring Business (2015-2020)13.10.5 Amphenol Advanced Sensors Recent Development13.11 Vaisala10.11.1 Vaisala Company Details10.11.2 Vaisala Business Overview10.11.3 Vaisala Pharmaceutical and Biotechnology Environmental Monitoring Introduction10.11.4 Vaisala Revenue in Pharmaceutical and Biotechnology Environmental Monitoring Business (2015-2020)10.11.5 Vaisala Recent Development13.12 Particle Measurement Systems10.12.1 Particle Measurement Systems Company Details10.12.2 Particle Measurement Systems Business Overview10.12.3 Particle Measurement Systems Pharmaceutical and Biotechnology Environmental Monitoring Introduction10.12.4 Particle Measurement Systems Revenue in Pharmaceutical and Biotechnology Environmental Monitoring Business (2015-2020)10.12.5 Particle Measurement Systems Recent Development13.13 Hanwell10.13.1 Hanwell Company Details10.13.2 Hanwell Business Overview10.13.3 Hanwell Pharmaceutical and Biotechnology Environmental Monitoring Introduction10.13.4 Hanwell Revenue in Pharmaceutical and Biotechnology Environmental Monitoring Business (2015-2020)10.13.5 Hanwell Recent Development13.14 Novatek10.14.1 Novatek Company Details10.14.2 Novatek Business Overview10.14.3 Novatek Pharmaceutical and Biotechnology Environmental Monitoring Introduction10.14.4 Novatek Revenue in Pharmaceutical and Biotechnology Environmental Monitoring Business (2015-2020)10.14.5 Novatek Recent Development

14 Analysts Viewpoints/Conclusions

15 Appendix15.1 Research Methodology15.1.1 Methodology/Research Approach15.1.2 Data Source15.2 Disclaimer15.3 Author Details

About Us:

QYResearch always pursuits high product quality with the belief that quality is the soul of business. Through years of effort and supports from huge number of customer supports, QYResearch consulting group has accumulated creative design methods on many high-quality markets investigation and research team with rich experience. Today, QYResearch has become the brand of quality assurance in consulting industry.

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