StemCell Therapy

RALEIGH The western flower thrips an invasive insect thats not much bigger than a pinhead takes a huge bite out of agriculture around the world, racking up billions of dollars worth of damage on a wide range of food, fiber and ornamental crops each year. Scientists now have a complete genetic blueprint to help them better understand the pest and to find ways to control it.

The research fills a significant gap in agricultural science and insect science: It highlights the first genome sequence and analysis for a member of Thysanoptera, an order that contains over 7,000 species of small insects with fringed wings.A journal article on the researchwas published open-access inBMC BiologyOct. 19.

Dorith Rotenberg, associate professor in NCStates Department of Entomology and Plant Pathology, is lead author of the paper. Fifty-six other researchers from universities and research institutions on five continents contributed.

Rotenberg said that the size of the team reflects the importance of the western flower thrips, orFrankliniella occidentalis,which is known to feed on hundreds of types of field and greenhouse-grown crops.

Theyre on everything flowers, fruit trees, solanaceous crops you name it, Rotenberg said. Theyre a major pest of the Southeast U.S. and California as well as anywhere around the world you have a lot of fruits and vegetables growing.

The project to sequence the thrips genome is affiliated withi5k, an ambitious international effort to sequence and analyze the genomes for 5,000 arthropod species insects, crustaceans, spiders and other creatures with exoskeletons, segmented bodies and pairs of jointed legs.

The i5k initiative focuses on species important to agriculture, food safety, medicine and energy production and contributes to our understanding of evolutionary biology, ecology and more.

Rotenberg and her colleagues got started on the western flower thrips genome project by developing an inbred line of thrips. The Human Genome Sequencing Center of the Baylor College of Medicine then sequenced the genome and assembled it, and Rotenberg recruited scientists from around the world to manually check the automated DNA annotation, verifying the location of genes and determining what those genes do.

Western flower thrips are native to the western North America, but since the 1970s, they have spread quickly throughout the world. The insect damages plants not only by feeding and laying their eggs on them but also by infecting plants with viruses, including the devastatingly difficult-to-control tomato spotted wilt virus.

Tomato spotted wilt virus, or TSWV, has been known to infect more than 1,000 plant species, ranging from tobacco and peanuts to pansies and chrysanthemums. In fact, TSWVs host range is among the largest for plant viruses, and so is its geographical range.

While theres been lots of research in recent decades aimed at curbing the toll that the virus and western flower thrips take on agriculture, Rotenberg said the genome could speed the development of solutions by helping researchers pinpoint molecular-level targets among the insects nearly 17,000 genes.

During the genome assembly project, scientists identified sets of genes related to the insects ability to thrive. Specifically, they found genes associated with the insects ability to develop and reproduce, to find plant hosts through taste and smell, to protect itself from pathogens and to detoxify chemicals that plants produce to repel insects and that humans use to kill them.

As Rotenberg noted, controlling the western flower thrips is difficult because the insect reproduces rapidly and becomes resistant to insecticides. In cotton, for example, theres evidence that thrips have evolved resistance to 19 insecticides within six groups with different modes of action.

Entomologists and growers know this very well: Thrips are notorious for building up resistance very quickly, Rotenberg said. And so you have to consider developing and using different types of chemicals and integrating alternative control strategies to manage this pest.

Already, the availability of the western flower thrips genome is having an impact, Rotenberg says. In her NCState lab, shes using the genome to advance her efforts to better understand the molecular-level interactions that take place between the western flower thrips and TSWV research that could be vitally important to disease prevention.

We want to find the molecules in the insect that interact directly with the virus that it transmits because if we know those molecules, then we can perhaps disrupt them in some way by interfering with the binding of the virus to the molecule of interest, she said.

And this is just the tip of the iceberg. Hopefully, (the genome) will be a resource that people can use for a long time, even as others start to develop new technologies or new resources that are even better.

(C) NCSU

Visit link:
'A major pest:' NCSU researcher helps unravel genetic blueprint of a bug 'that's on everything' - WRAL Tech Wire

BLOOMINGTON, Ind. -- As part of its ongoing efforts to manage and control COVID-19 on its campuses, Indiana University has started operating its own labs for COVID-19 testing. Since the university first started mitigation testing -- sometimes referred to as surveillance testing -- with its students, faculty and staff in August, tests were completed on campus and then sent to a third-party lab for analysis and results.

The new labs, in Bloomington and at the IU School of Medicine on the IUPUI campus, will be able to run the tests and provide this analysis. IU has been doing about 15,000 tests per week since the fall semester started. With the new labs online, the university will be able to complete 35,000 tests per week with the ultimate goal of doing 15,000 tests per day.

"We know the mitigation testing we've been doing on all IU campuses is a key piece of keeping cases low in our campus communities and maintaining the health and safety of our students, faculty and staff," said Dr. Aaron Carroll, director of mitigation testing, and professor of pediatrics and health outcomes research leader at the IU School of Medicine. "With these new labs, I'm excited to be able to further enhance our mitigation testing with more frequency and including a larger number of people in each week's sample group."

The labs are overseen by IU School of Medicine faculty members Aaron Ermel and Gail Vance and IU Bloomington faculty member Craig Pikaard. Trained lab staff will work with a variety of technology in the labs to analyze the thousands of mitigation tests completed each week at IU campuses. Liquid handling robots handle and process the saliva samples collected as part of the tests used during mitigation testing. From these samples, the lab determines if genetic material from the virus is in the sample. If genetic material is detected, the test is positive. If not, the test is negative for COVID-19.

"As we begin processing these tests at the university, our students, faculty and staff will notice much faster turnaround times for test results -- likely 24 hours or less," Carroll said.

Otherwise, he said, the mitigation testing process will remain the same. Emails will still be sent to people selected in each week's testing group, appointments will be need to be scheduled (although now through IU instead of Vault, the previous lab being used), and results will still be sent via email.

As the IU labs expand the number of tests they do each day, IU campuses will shift from Vault to using the IU labs exclusively. Tests from IU Bloomington are starting to be analyzed in the labs now, with tests from IUPUI and the regional campuses starting to use the labs in the near future.

"In addition to the cost efficiencies with operating our own labs, having the ability to run these tests here allows us to spot any trends or potential outbreaks and take appropriate public health actions in a much more timely manner," Carroll said. "Especially with COVID-19 cases increasing across the state and country, this continued testing is one of the best ways we have to manage the virus and hopefully avoid any outbreaks."

The labs will focus on mitigation testing for now but may also move into close contact testing, confirmatory testing for antigen ("rapid") tests and possibly even symptomatic testing in the months to come.

More here:
IU has started operating its own labs for COVID-19 mitigation testing - IU Newsroom

And in September, Senator Elizabeth Warren of Massachusetts and three other members of Congress called on the Department of Health and Human Services to investigate their use, warning that they risk embedding racism into medical practice.

Some medical institutions have stopped using race corrections in some tests. MGH and Brigham and Womens Hospital, for example, no longer adjust the results of a popular test for kidney functions, called eGFR. Critics worried the adjustment had tended to make kidney functions of Black patients look better, possibly concealing genuine problems and causing dangerous delays in needed medical care. Last week, a new study from Brigham and Womens Hospital concluded that eliminating race correction in kidney disease tests would qualify up to one in every three Black patients for more advanced care and that might result in more effective treatment of the disease.

There have been several reports of computer algorithms that produce racially biased results, such as facial recognition programs that can accurately identify white people, but not Black people. Earlier this year, a Black man in Michigan was arrested after facial recognition software falsely identified him as a criminal suspect. Such problems are usually a byproduct of the software development in this case, using too few photos of Black people to train the software to recognize dark-skinned faces.

Racial corrections for medical diagnostic tests were created on purpose. Consider the spirometer, used to measure lung capacity. The devices often require doctors to enter the race of the patient prior to the test, based on research dating back as far as the 19th century that indicates Black people have lower lung capacity than white people.

Other examples include an algorithm used to estimate the risk to the health of a pregnant woman planning to give birth vaginally, if she has previously undergone a caesarean birth. The race-adjusted algorithm predicts that vaginal birth is more dangerous for Black and Hispanic women than for white women. But for most women, vaginal deliveries result in fewer complications and faster recovery times. Vyas speculates that the algorithm may discourage doctors from offering vaginal deliveries to women of color, who already face a higher rate of maternal mortality.

The problem, according to Vyas, is that doctors and scientists are treating race as a clear-cut biological reality when it isnt. Research in population genetics has shown that apart from features such as skin color and hair texture, theres not that much difference genetically among people of different races. And the differences are bound to diminish even further, as interracial marriage becomes routine in the United States.

We know that race is not a biologic category, said Vyas. Its not genetic. Its a social construct.

Still, a variety of tests appear to show real differences between Black and white patients. The race correction for eGFR kidney tests was developed after large-scale research studies found that the test tended to underestimate kidney function in Black people.

Another example of the biology vs. environment tension involves the coronavirus. In a new paper in the Journal of the American Medical Association, researchers from the Mount Sinai School of Medicine reported that a gene associated with higher risk of contracting COVID-19 is more commonly found in the nasal tissues of Black people than white people. This genetic difference could help explain why such a high percentage of Black people in the US get infected.

But that doesnt prove that race is the reason. Vyas argues scientists should look for other explanations, such as the effects of systemic racism. For example, Black people are more likely to live in poverty, which exposes them to greater health risks. Vyas also said the psychological stress of coping with constant racism could affect the health outcomes of Black patients.

"Its not okay to just mention race without talking about racism, Vyas said.

The lead authors of the Mount Sinai study take note of this too, arguing that environmental and social factors play a role in the activation of genes. This could explain why Black people are more vulnerable to COVID-19.

Even a physician who helped develop the race-corrected algorithm for kidney tests agreed the practice has its limitations. But Lesley Inker, director of the Kidney and Blood Pressure Center at Tufts Medical Center, cautioned that failing to take race into account could also lead to faulty diagnoses in some cases.

For example, diabetes is the number-one cause of kidney failure among Black people. But because of potential side affects, current medical practice advises not administering two of the most effective drugs for diabetes to patients with low eGFR scores. Removing race correction from the kidney test would lower the scores of Black patients and make some of them ineligible for diabetes drugs that could help save their kidneys.

This is complex, and theres lots of pros and cons and balancing acts which should be considered prior to acting, Inker said.

Inker warns that giving up on these corrections too quickly might be dangerous. For instance, cardiologists have recently adopted a new way of assessing heart disease risk that takes race into account. For years, doctors have relied on data from a massive study of heart disease in Framingham, which began in 1948 and continues to this day. But the population of that study is overwhelmingly white. Now doctors supplement that data with an algorithm based on data from thousands of Black patients, and have found that the new approach is better at providing early warning of heart disease in Black people.

Melissa Simon, who heads the Center for Health Equity Transformation at Northwestern University Medical School in Chicago, said doctors need more data to understand the different health outcomes between Black and white people. In 2015, the National Institutes of Health launched a Precision Medicine Initiative that hopes to use genetic data and detailed information about a patients lifestyle and habits to determine the ideal course of treatment for each individual. Simon hopes that kind of highly personalized medicine could eliminate the need for race-based diagnostics altogether.

Updated with a new study on race correction in kidney disease tests.

Hiawatha Bray can be reached at hiawatha.bray@globe.com. Follow him on Twitter @GlobeTechLab.

Go here to read the rest:
A new push to remove race-based assessments in medicine - BetaBoston

Chongtao Du,1,* Yuyang Feng,1,* Guizhen Wang,2 Zhiyuan Zhang,1 Huimin Hu,1 Yu Yu,1 Jiayang Liu,1 Lihao Qiu,1 Hongtao Liu,1 Zhimin Guo,3 Jing Huang,3 Jiazhang Qiu1

1Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, Peoples Republic of China; 2College of Food Engineering, Jilin Engineering Normal University, Changchun 130052, Peoples Republic of China; 3Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun 130021, Peoples Republic of China

*These authors contributed equally to this work

Correspondence: Jiazhang QiuCollege of Veterinary Medicine, Jilin University, No. 5333 Xian Road, Changchun 130062, Peoples Republic of ChinaEmail qiujz@jlu.edu.cnJing HuangDepartment of Clinical Laboratory, The First Hospital of Jilin University, Changchun 130021, Peoples Republic of ChinaEmail huangj@jlu.edu.cn

Objective: A colistin-resistant Escherichia coli strain isolated from dog feces was characterized in this study.Methods and Results: A multiplex PCR assay was used to detect the presence of colistin-resistant mcr genes; it was found that E. coli QDFD216 co-harbored the mcr-1 and mcr-3 genes. Whole-genome sequencing and further bioinformatics analysis revealed that E. coli QDFD216 belonged to serotype O176:H11, fimH1311 type and ST132. The resistance genes blaCTX-M-14, mdfA, dfrA3, acrA, acrB, tolc, and sul3 were present in the chromosome. The mcr-1.1 and mcr-3.7 genes were located in two plasmids of different incompatibility groups. mcr-1.1 was carried by a IncX4-type plasmid within an typical IS 26-parA-mcr-1.1-pap2 cassette, while mcr-3.7 was encoded by an IncP1-type plasmid with a genetic structure of TnAs2-mcr-3.7-dgkA-IS 26. No additional antibiotic resistance genes were carried by either plasmid.Conclusion: This is the first report of an E. coli isolate co-harboring a mcr-1.1-carrying IncX4 plasmid and a mcr-3.7-carrying IncP1 plasmid. The evolution and mechanism of mcr gene co-existence need further study to assess its impact on public health.

Keywords: colistin resistance, whole-genome sequencing, mcr genes, mcr-1, mcr-3

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

See the original post here:
Co-Occurrence of the mcr-1.1 and mcr-3.7 Genes in a Multidrug-Resistan | IDR - Dove Medical Press

New York, Oct. 21, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Cell Therapy Instruments Market Forecast to 2027 - COVID-19 Impact and Global Analysis by Product ; Cell Type ; Process ; End User, and Geography" - https://www.reportlinker.com/p05978058/?utm_source=GNW On the other hand, high cost of cell therapy production and cell therapy are expected to hinder market growth.The growing advancements in biotechnology have led to the introduction of personalized treatments for people suffering from various health conditions.For instance, stem cell and immune cell therapies are preferred to treat chronic diseases such as cancer, diabetes, neurological disorders, and genetic disorders.

Further, the cell therapy advantages, such as targeted treatment, faster and efficient recovery, and reduced side effectspromote the launch of various products in the market, thereby increasing the production volume.

In North America and Europe, cell therapies are widely adopted owing to the availability of the US Food and Drug Administration (FDA) approved products in the market.For instance, in April 2020, FDA awarded regenerative medicine advanced therapy (RMAT) designation to Novartis Kymriah (tisagenlecleucel) to treat refractory (r/r) follicular lymphoma (FL) in adults.

The company claims that the therapy has the potential to treat acute lymphoblastic leukemia (ALL) and r/r adult diffuses large B-cell lymphoma (DLBCL) in children and young adults.Similarly, in October 2017, Kite, a Gilead, received an approval from FDA for its Yescarta, the first chimeric antigen receptor T cell (CAR T) therapy that treats refractory large B-cell lymphoma after two or more steps of systemic therapy in adults. In June 2020, the company announced the opening of a manufacturing hub in Amsterdam after it received an approval from the European Medicines Agency (EMA).There are several ongoing clinical trials for cell therapies; thus, to commercialize cell therapy products to the masses, manufacturers need to increase their production capacity.Various market players such as ThermoFisher Scientific Inc, Cytiva, Danaher Corporation, and Lonza are offering laboratory instruments.

Also, the rising demand for cell therapies have attracted biotechnology startups to enter the cell therapy domain. Thus, various biopharmaceutical companies and startups have increased their production, which has eventually increased the demand for cell therapy instruments.

Based on product, the cell therapy instrumentmarket is segmented into the consumables, equipment, systems, and software.In 2019, the consumables segment accounted for the highest share of the market.

The growth of the segment is attributed to the rising research activities that demand reagents, kits, and lab wares in higher quantity.Also, the increased production for commercialization has influenced the market for the consumables segments.

Additionally, the rising adoption of cell therapy has increased the demand for storage consumables to supply and distribute it to the desired places.

Based on cell type, the cell therapy instrumentsmarket is segmented into human cells and animal cells.The human cells segment held a larger share of the market in 2019, and is estimated to register a higher CAGR in the market during the forecast period.

The growth of segment is determined to growing research based on human cells to derived personalized medicines as the genetic makeup of a patient, and growing product developments for the human cells.

Based on process, the cell therapy instrumentsmarket is segmented into cell processing, process monitoring and quality control, and cell preservation, distribution, and handling. The cell processing segment held the largest share of the market in 2019, and is estimated to register the highest CAGR in the market during the forecast period.

Based on end user, the cell therapy instruments market is segmented into research institutes, life science research companies, and other end users. The life science research companies segment held the largest share of the market in 2019, and same segment is estimated to register the highest CAGR of 14.0% in the market during the forecast period.

The Food and Drug Administration, European Medicines Agency, Italian Medicines Agency, The Global Burden of Disease Study, American Society of Gene & Cell Therapy, and Ministry of Health and Preventionare among the major secondary sources referred for preparing this report.Read the full report: https://www.reportlinker.com/p05978058/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

__________________________

Continued here:
Cell Therapy Instruments Market Forecast to 2027 - COVID-19 Impact and Global Analysis by Product ; Cell Type ; Process ; End User, and Geography -...

Prime editing is the gene-editing method that can insert, delete and do base swapping accurately. Prime editing also termed as genetic word processor precisely select the target DNA and replace genetic code. Targeting 75,000 different mutations and correcting 89% of genetic defects will drive the demand for prime editing. In 2017, the first gene editing in the human body was attempted. Gene editing in a patient with Hunters syndrome was tested for safety and concluded reliable shreds of evidence. Superior target flexibility and editing precision with minimal errors make Prime editing first preference over the other conventional technique such as CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats). Application of prime editing in reversing Genetic disease will be a milestone in gene editing.

For more insights into the Market, request a sample of this report @https://www.persistencemarketresearch.com/samples/31691

Increasing prevalence of genetic disease creates a huge opportunity for prime editing market. Successful preliminary results with a genetic disease like Tay Sachs and Sickle cell anaemia will drive the prime editing market. Technological advancements providing minimal error with this technique will fuel the growth of prime editing. Decreased cost of DNA sequencing will propel prime editing market for research and commercialization. Arising ethical and safety concerns will make prime editing highly regulated sector. This may limit the scope and can restraint the growing market. Detrimental effect on Genetic diversity due to genetic engineering in one way may limit the market scope.

For Information On The Research Methodology request here @https://www.persistencemarketresearch.com/methodology/31691

The global Prime Editing market is classified on the basis of application and end user:

Based on application, Prime Editing Market is segmented into following:

Based on end user, Prime Editing Market is segmented into following:

To receive extensive list of important regions, Request TOC here @https://www.persistencemarketresearch.com/toc/31691

Prime Editing is the most recent invention has created a buzz in the market. Firms accessing conventional genome engineering technologies have rolled plans of transitioning to this new technology. The restructuring by the firms is either by building upon the technological capabilities or by merging or acquiring the firms which hold expertise in prime editing. Inscripta, one of the most innovative company has launched the worlds first benchtop platform for digital genome engineering. Inscriptas Onyx device that was launched in October 2019, will enable genome editing at an unprecedented scale and cheaper rate. In 2019, Beam Therapeutics collaborated with a premium start-up in prime editing segment Prime Medicine for Prime Editing Technology. Beam therapeutics holds expertise in precision genetic medicine using base editing technology. The market consolidation activities my giants depict that genome editing will be the largest revenue-generating segment for prime editing market.

North America will drive the market for Prime Editing due to high prevalence of genetic disease and technological advancement in the U.S. and Canada. One in every 27 Jews, is carrying Tay Sachs disease gene. After North America, Europe is leading in patient pool for genetic diseases such Hemophilia and Cystic fibrosis. The genetic disease pool will drive the adoption for Prime editing treatments in this region. Asia-Pacific will remain at steady growth for Prime Editing market due less disease prevalence and focus on other therapies. Latin America and Middle East and Africa region will boost the market owing to the disease prevalence.

Examples of some of the market participants in Prime Editing market identified across the value chain Beam Therapeutics Inc., Precision BioSciences, Inscripta, Inc, Horizon Discovery Ltd., Sangamo Therapeutics, Inc., CRISPR Therapeutics., Intellia Therapeutics, Inc.

Explore Extensive Coverage of PMR`sLife Sciences & Transformational HealthLandscape

Persistence Market Research (PMR) is a third-platform research firm. Our research model is a unique collaboration of data analytics andmarket research methodologyto help businesses achieve optimal performance.

To support companies in overcoming complex business challenges, we follow a multi-disciplinary approach. At PMR, we unite various data streams from multi-dimensional sources. By deploying real-time data collection, big data, and customer experience analytics, we deliver business intelligence for organizations of all sizes.

Our client success stories feature a range of clients from Fortune 500 companies to fast-growing startups. PMRs collaborative environment is committed to building industry-specific solutions by transforming data from multiple streams into a strategic asset.

Contact us:

Naved BegPersistence Market ResearchAddress 305 Broadway, 7th Floor New York City,NY 10007 United StatesU.S. Ph. +1-646-568-7751USA-Canada Toll-free +1 800-961-0353Salessales@persistencemarketresearch.comWebsitehttps://www.persistencemarketresearch.com

Source MARKITWIRED

Read more here:
The Prime Editing market to get on to the elliptical growth mode in the next decade - PharmiWeb.com

A new study led by scientists at IUPUI and Indiana University Bloomington is the first to describe a biochemical mechanism that increases the activity of a molecule whose presence is observed in many types of cancer.

The molecule, an enzyme called Pif1 helicase, plays a role in many important cellular processes in the body. Tightly regulating this protein is vital to genome stability because too little -- or too much -- activity can influence aging and age-related diseases, primarily cancer. A common cancer therapy, HDAC inhibitors, can also impact the mechanism that regulates this enzyme.

"We're currently giving people drugs that change the acetylation status of the cell without knowing how it affects many proteins that play a role in genome stability," said Lata Balakrishnan, an associate professor of biology in the School of Science at IUPUI, who is co-lead author on the study. "HDAC inhibitors upregulate certain tumor-suppression genes, and thus are used in combination therapies to treat specific cancers, but when it comes to their impact on other parts of the cell, we're basically operating in the dark."

The study's other lead author is Matthew Bochman, an associate professor in the IU Bloomington College of Arts and Sciences' Department of Molecular and Cellular Biochemistry. Other co-authors are Christopher Sausen and Onyekachi E. Ononye, Ph.D. students in Bochman's and Balakrishnan's labs, respectively, at the time of the study.

The effect of lysine acetylation on Pif1 is the mechanism described in the study. Lysine acetylation occurs when a small molecule called an acetyl group binds to lysine, an amino acid used to build common proteins in the body. This action transforms lysine from a positively charged molecule to a neutrally charged molecule. This neutralization can impact protein function, protein stability and protein-protein interaction in cells, among other things.

Helicases are known as the genetic "zippers" of cells because they pull apart DNA for the purpose of genetic replication and repair. They also help maintain telomeres, the structure at the end of chromosomes that shortens as people age.

In the new study, the researchers identified lysine acetylation on Pif1 helicase and showed the addition of the acetyl group increases the protein's activity -- as well as its "unzipping" function. They also found that lysine acetylation changes the shape -- or "conformation" -- of the Pif1 protein. They believe that this shape change increases the amount of Pif1 helicase.

"The dynamic interplay of the addition and removal of the acetyl group on lysine regulates a wide variety of proteins within the cell," Balakrishnan said. "Perturbations to this process can play a role in cancer, aging, inflammatory responses and even addiction-related behaviors."

"As a class, helicases are involved in a lot of processes necessary for genome integrity," Bochman added. "Any significant failure in these processes is generally carcinogenic."

The precise details of lysine acetylation in Pif1, its effect of the enzyme's shape and the resulting impact on helicase activity took nearly five years to observe and report. The study, carried out in parallel on two IU campuses, was made possible by the lead scientists' complementary expertise. As a biochemist who has previously studied lysine acetylation in other proteins, Balakrishnan was able to isolate Pif1 in vitro to observe its response to chemical reactions in a test tube. In contrast, as a geneticist working in yeast as a model organism to study Pif1, Bochman was able to modify cells in vivo to watch reactions play out in a living organism.

"The ability to observe these reactions in a living cell is often more relevant, but it's also a lot messier," Balakrishnan said. "Our experiments were constantly informing each other as to where to go next."

Looking to the future, Bochman said intricate knowledge of cellular processes -- such as lysine acetylation -- will increasingly play a role in personalized therapy.

"If you sequence a patient's tumor, you can fine-tune drugs to target very specific enzymes," he said. "Instead of a drug that broadly affects the whole cell, it will be possible to take a targeted approach that reduces potential side effects. This level of personalization is really the future of cancer biology and cancer medicine."

"Lysine Acetylation Regulates the Activity of Nuclear Pif1" is available online in advance of print in the Journal of Biological Chemistry. A perspective article on the work is also forthcoming in the journal Current Genetics.

This work was supported in part by the National Science Foundation, the National Institutes of Health and the American Cancer Society.

Indiana University's world-class researchers have driven innovation and creative initiatives that matter for 200 years. From curing testicular cancer to collaborating with NASA to search for life on Mars, IU has earned its reputation as a world-class research institution. Supported by $854 million last year from our partners, IU researchers are building collaborations and uncovering new solutions that improve lives in Indiana and around the globe.

View post:
Study reports chemical mechanism that boosts enzyme observed in cancer - IU Newsroom

It shouldnt really need to be stated that your eyesight of the utmost importance when youre on the road. Driving primarily relies on your ability to see around you and to react to changes in your environment by picking up on them visually. There are a lot of drivers who have to wear glasses or contacts in order to do it effectively, but you might feel a little less confident about getting the wheel if you dont have 20/20 vision. Here are a few tips that can help you feel a little safer.

Image CC0 License

Get your vision tested

First of all, if youre worried that your vision has changed since the last time you have gotten behind the wheel, or that it has shifted gradually over the past months, then its important to get to the truth of the matter. Arrange a vision test with your optometrist and they can give you definitive answers on whether or not any such changes have occurred. Most importantly, they will be able to inform you as to whether or not you can safely drive on the road. If they say you cannot, then take that as a rule of law, as you can get in trouble if you ignore their advice.

Choose the right glasses

A good eye test will be able to help you get your prescription down, but you still need to pick a good pair of glasses. You can find a store and quickly pick up a pair of frames without issue, but you should take the time to make sure that theyre right for driving with. For one, its a good idea to make sure youre not using frames with chunky edges and choose larger lenses so that youre better able to keep your peripheral vision while driving. You might even want to choose a pair of glasses that use transparent elastic bands to hold frames in place, though they can cost a little more and might not be essential.

Always be prepared

You should always ensure that you have a spare pair of glasses in the glove compartment of your car. That way, should your glasses fall off of your forget to bring them with you, you can make sure that you can hop right back into action. You dont want to be fishing around the floor of your car looking for glasses on the side of the road. Similarly, keep a pack of glasses cleaning wipes at hand so that you can keep your vision clear without too much hassle. Otherwise, if you want to make sure that you have a little added protection on the road, then choose a car that has great safety options just to offer you some peace of mind.

Beware the glare

Its a problem that many glasses wearers are already aware of but, if you havent driven in glasses before, you might be surprised just how much of a headache it can be, literally and metaphorically. For people with issues like astigmia, the glare caused by sunlight hitting your glasses (and the windshield) can cause headaches that can distract you while youre driving. Most people are going to have trouble driving with the sun glaring in their eyes, anyway. There are anti-reflecting coats that can help you, however. These coatings can protect your eyes from the sun, as well as other sources of light, such as taillights, street lamps, and more. That way, you can make sure that youre driving free of distraction.

Use your night driving tools

If youre worried about your vision, then perhaps the tip that will put you best at ease is to simply not drive at night. However, in some cases, it might not be that easy so you should at least be prepared. To that end, you should consider getting a pair of night vision glasses specifically made for people who experience night blindness. Otherwise, make sure that youre relying on the tools that are already at your disposal, such as aiming your car forward at the road accurately. Before you go out driving in the evenings, take care to clean your headlights, too, as grime from the road can build up to obscure them and diminish their ability to light the road ahead properly.

If your vision is really that bad, you wont be allowed to drive on the road and that will be that. Otherwise, keep the tips above in mind to ensure youre always taking the best care of yourself.

Like Loading...

Here is the original post:
Feel Safer When Driving With Bad Eyesight - The Intelligent Driver

Over 3 crore individuals suffer from blindness globally, with India being home to nearly one-third the total figure. While 80 percent of vision impairment can be prevented by early detection and timely intervention, lack of access and awareness has been a major deterrent in individuals seeking eye care. Also Read - Kangana Ranaut Looks Resplendent in Rs 1,35,000 Pastel Blue Chanderi Lehenga, Pearls for Cousin's Wedding in Manali

Reduced eyesight is caused by multiple factors, including diseases like diabetes, eye trauma, cataracts, or glaucoma. Also Read - Weight Loss Tip: Brain, Not Willpower, Decides if You Will Lose Weight Or Not

Over 5 crore people in India have moderate to severe vision impairment which has impacted their personal and professional lives, says Ramesh Pillai, Chief Optometrist & Head of Training, Titan Company Ltd, Eyewear Business. The onslaught of COVID-19 has also led to an increase in screen-time for people across ages and this has been a major factor in declining eye health. Eye care and eye health have become more of a necessity, he adds. Also Read - Second Wave Of COVID-19 in India, Experts Say Possibility of it Cannot Be Ruled Out in Winters

He suggests five simple and effective ways to ensure good eye health:

Right Glasses

Wearing branded Sunglasses that offer 100 percent UV protection while outdoors can help protect your eyes from the harmful impact of UV rays and Cataract formation. Wearing the right spectacles for screen usage like anti-reflection lenses with Blue Coating is extremely important. The Blue coating helps in blocking the harmful blue-violet and allows the essential blue turquoise to help the circadian rhythm and thereby maintain the sleep-wake cycle.

Right Diet

Eating leafy green vegetables such as spinach, kale and broccoli contain Lutein and zeaxanthin to help prevent cataracts. Lutein also stimulates the growth of pigments that help block out harmful UV rays. Food rich in Vitamins C and E and zinc, reduce the risk of developing a condition called Age-Related Macular Degeneration (ARMD). Antioxidants protect against sun damage. Good sources of antioxidants include egg yolk, yellow peppers, pumpkins, sweet potatoes, carrots, blueberries. Onions, shallots, garlic, capers contain sulphur, cysteine, and lecithin, which help against cataract formation.

Keep Eyes Moist

Dry eyes are a major irritant, especially as the pollution gets worse day by day. Resting the eyes often and blinking moistens the eyes, reducing dryness and irritation. One can also use drops to help keep your eyes moist in case of excess dryness.

Screen Protection

With an increase in screen-time becoming an inevitable reality, taking good care of your eyes is paramount. Use the 20-20-20 rule, by taking a 20-second screen break every 20 minutes to look at objects 20 feet away from you. Increase font size when reading on-screen, so that devices dont need to be too close to your eyes, and you dont have to squint. A clean screen boosts visibility, wipe your screen over at least once a day.

Get tested

Getting your eyes tested by a qualified Optometrist or an Eye Doctor once every year is very important. Regular eye examinations help find any symptoms associated with eye strains and provide solutions for the same. Titan Eyeplus on the occasion of World Sight Day has introduced an initiative online screen testing. Take out 60 seconds and take a simple online eye screening test that will give you an indication of whether you suffer from eyesight problems. Basis screening results, the brand requests all to visit an ophthalmologist or optician.

Go here to read the rest:
Eye Health: Follow These 5 Tips To Take Care of Your Eyesight - India.com

Since the onset of the COVID-19 pandemic, millions of adults and children have increased screen time on computers, tablets and phones. This prolonged screen time can lead to eye discomfort, fatigue, blurred vision, headaches, and dry eyes. Low lighting, glare, improper workstation set-up and undiagnosed visual problems can make things worse. When we look at a screen for a prolonged period without a break, this can lead to eye irritation and dry eyes, due to reduced blinking, with accommodative problems (difficulty focusing near and far). Children tend to ignore these symptoms, which can lead to excessive eye strain.

Ways to reduce these symptoms:

Take a scheduled 10-minute break for every hours work;

Adjust the computer to the childs body, using an adjustable chair height and footstool to help;

Check the lighting on the computer and avoid direct light on to the screen. Use dinner lighting instead of bright overhead lights;

Treat dry eyes and do eye exercises;

An annual eye examination will help diagnose refractive errors that need correction.

The following populations need additional preventative measures:

All patients 12 years and older with diabetes mellitus should have their eyes checked at least once a year. Interventions include putting eye drops in the eyes by a trained person, screeners, optometrists and ophthalmologists. An examination of the back of the eye (the retina) will detect diabetic retinopathy early. We encourage all people with diabetes to take along their clinic passports so we can make a note. You can reduce diabetic retinopathy by controlling your glucose levels and keeping your blood pressure and cholesterol levels at normal levels.

Glaucoma is common in our population. Persons can have normal vision in early and moderate glaucoma because the outer (peripheral) vision is affected first. One may not appreciate this visual loss until it is late, because when we open both eyes, they each help with peripheral vision. The reading vision is usually affected in advanced glaucoma (end-stage). All patients over 40 years should have their eyes screened for glaucoma. Risk factors apart from your heritage include patients with a family history. Short-sighted persons (high myopes) may need screening before age 40.

Patients around the age of 40 years may notice difficulty with seeing the fine print or have blurred vision while looking at their phone screens and may need to push the reading material some distance away to see. This condition is called presbyopia and is a normal phenomenon that usually requires glasses to improve near vision.

Patients with sickle cell disease (HbSS, HbSC) and patients on certain medications such as hydroxychloroquine (Plaquenil) should also have their eyes checked every year. We encourage patients, young and old with no medical conditions or other risk factors that may affect the eye to have at least a check on their eyes every two years. A healthy diet includes dark green and purple vegetables, and yellow/orange vegetables and fruits are good for your eyes. Remember to keep your eye appointments during this time, unless advised otherwise by your eye doctor.

Routine eye examinations can often detect and reduce the impact of visual impairment due to uncorrected refractive errors (the need for glasses and/or contact lenses), a significant cause of visual impairment. In children, a vision screen can detect treatable conditions, including refractive errors, strabismus (squint), eye cancers (retinoblastoma), congenital cataracts, and glaucoma. Undetected refractive errors can lead to the development of amblyopia, an irreversible visual loss in an otherwise healthy eye. Amblyopia can be treated if detected early. It is, therefore, essential that all preschool children (ages five to six) have an eye examination. Subsequently, children should have an eye examination every two years, if all else is healthy

Dr Amoy Ramsay is a consultant ophthalmologist at the Cornwall Regional Hospital.

Originally posted here:
Watch your eyes! - Taking care of your sight during the COVID-19 pandemic - Jamaica Gleaner

What Are Cookies

As is common practice with almost all professional websites, our site uses cookies, which are tiny files that are downloaded to your device, to improve your experience.

This document describes what information they gather, how we use it and why we sometimes need to store these cookies. We will also share how you can prevent these cookies from being stored however this may downgrade or break certain elements of the sites functionality.

How We Use Cookies

We use cookies for a variety of reasons detailed below. Unfortunately, in most cases there are no industry standard options for disabling cookies without completely disabling the functionality and features they add to the site. It is recommended that you leave on all cookies if you are not sure whether you need them or not, in case they are used to provide a service that you use.

The types of cookies used on this website can be classified into one of three categories:

Disabling Cookies

You can prevent the setting of cookies by adjusting the settings on your browser (see your browsers Help option on how to do this). Be aware that disabling cookies may affect the functionality of this and many other websites that you visit. Therefore, it is recommended that you do not disable cookies.

Third Party Cookies

In some special cases we also use cookies provided by trusted third parties. Our site uses [Google Analytics] which is one of the most widespread and trusted analytics solutions on the web for helping us to understand how you use the site and ways that we can improve your experience. These cookies may track things such as how long you spend on the site and the pages that you visit so that we can continue to produce engaging content. For more information on Google Analytics cookies, see the official Google Analytics page.

Google Analytics

Google Analytics is Googles analytics tool that helps our website to understand how visitors engage with their properties. It may use a set of cookies to collect information and report website usage statistics without personally identifying individual visitors to Google. The main cookie used by Google Analytics is the __ga cookie.

In addition to reporting website usage statistics, Google Analytics can also be used, together with some of the advertising cookies, to help show more relevant ads on Google properties (like Google Search) and across the web and to measure interactions with the ads Google shows.

Learn more about Analytics cookies and privacy information.

Use of IP Addresses.An IP address is a numeric code that identifies your device on the Internet. We might use your IP address and browser type to help analyze usage patterns and diagnose problems on this website and to improve the service we offer to you. But without additional information your IP address does not identify you as an individual.

Your Choice.When you accessed this website, our cookies were sent to your web browser and stored on your device. By using our website,you agree to the use of cookies and similar technologies.

More Information

Hopefully the above information has clarified things for you. As it was previously mentioned, if you are not sure whether you want to allow the cookies or not, it is usually safer to leave cookies enabled in case it interacts with one of the features you use on our site. However, if you are still looking for more information, then feel free to contact us via email at [emailprotected]

View post:
Eyesight of five of eight cataract op patients irreversibly damaged (Updated) - Cyprus Mail

(PRESS RELEASE) CINCINNATI, OH From October 8 10, OneSight, the leading global vision care nonprofit, teamed up with partner Fresh Air Fund and sponsors Fidelity Security Life Insurance, LCA Vision, Anthem and Wachter to provide eye exams and glasses to 200 New Yorkers.

The three-day charitable clinic, which kicked off on World Sight Day, Oct. 8th, addressed unresolved vision care needs for New Yorkers who may otherwise lack access. Leveraging OneSights proven clinic model and manufacturing capabilities, most participants in need of glasses received their newly prescribed eyewear on-site.

Caring for vulnerable populations has to be about more than just immediate need, said K-T Overbey, president and executive director at OneSight. Clear sight opens windows to the future it improves long-term educational, professional and social prospects. Our work improves quality of life, especially for individuals in need. Were extremely proud of the work we did on the ground in New York with our vision clinic.

On World Sight Day, OneSight also teamed up with other leading global vision nonprofits Clearly and IAPB to shine a light on the 230 million+ kids worldwide that need glasses, but dont have access to get them. They did this by launching the free digital childrens book Through the Looking Glasses: Stories About Seeing Clearly, which features 30 childrens stories and illustrations about seeing clearly by authors and artists from 17 countries.

The global initiative also included Bedtime Stories where celebrities, athletes and authors, such as Tennis Legend Billie Jean King; Restaurateur David Chang; Celebrity Michelle Yeoh; and TV Star Jo Frost, read stories from the book on World Sight day as tens of thousands participated around the world.

To learn more about OneSight, World Sight Day, and download the free digital book Through the Looking Glasses, visit http://www.onesight.org/worldsightday

Read this article:
Onesight Provides Vision Care to 200 New Yorkers at NYC Vision Clinic on World Sight Day - InvisionMag

Share this Article

You are free to share this article under the Attribution 4.0 International license.

New generation CRISPR technology could pave the way for therapeutics to treat inherited retina diseases, researchers report.

In this proof-of-concept study, we provide evidence of the clinical potential of base editors for the correction of mutations causing inherited retinal diseases and for restoring visual function, says Krzysztof Palczewski, chair and a professor in the Gavin Herbert Eye Institutes ophthalmology department at the University of California, Irvine School of Medicine. Our results demonstrate the most successful rescue of blindness to date using genome editing.

Inherited retinal diseases (IRDs) are a group of blinding conditions caused by mutations in more than 250 different genes. Previously, there was no avenue available for treating these devastating blinding diseases. Recently, the FDA approved the first gene augmentation therapy for Leber congenital amaurosis (LCA), a common form of IRD which originates during childhood.

As an alternative to gene augmentation therapy, we applied a new generation of CRISPR technology, referred to as base editing as a treatment for inherited retinal diseases, says first author Susie Suh, assistant specialist in the ophthalmology department.

We overcame some of the barriers to the CRISPR-Cas9 system, such as unpredictable off-target mutations and low editing efficiency, by utilizing cytosine and adenine base editors (CBE and ABE). Use of these editors enabled us to correct point mutations in a precise and predictable manner while minimizing unintended mutations that could potentially cause undesirable side effects, says co-first author Elliot Choi, also an assistant specialist in the ophthalmology department.

Using an LCA mouse model harboring a clinically relevant pathogenic mutation in the Rpe65 gene, the researchers successfully demonstrated the therapeutic potential of base editing for the treatment of LCA and by extension other inherited blinding diseases.

Among other results, the base editing treatment restored retinal and visual function in LCA mice to near-normal levels. Base editing was developed at the Broad Institute of MIT and Harvard in the lab of David Liu.

After receiving treatment, the mice in our study could discriminate visual changes in terms of direction, size, contrast, and spatial and temporal frequency, says Palczewski.

These results are extremely encouraging and represent a major advance towards the development of treatments for inherited retinal diseases.

Gene therapy approaches to treating inherited retinal diseases are of special interest given the accessibility of the eye, its immune-privileged status, and the successful clinical trials of RPE65 gene augmentation therapy that led to the first US Food and Drug Administration-approved gene therapy.

Now, as demonstrated in this study, base-editing technology can provide an alternative treatment model of gene augmentation therapy to permanently rescue the function of a key vision-related protein disabled by mutations.

The new paper appears in Nature Biomedical Engineering.

Support for the research came from the National Institutes of Health; the Research to Prevent Blindness Stein Innovation Award; Fight for Sight; the Eye and Tissue Bank Foundation (Finland); the Finnish Cultural Foundation; the Orion Research Foundation; the Helen Hay Whitney Foundation; US Department of Veterans Affairs; and a Research to Prevent Blindness unrestricted grant to the Department of Ophthalmology, University of California, Irvine.

Source: UC Irvine

Continue reading here:
Therapy restores vision in mice with retina disease - Futurity: Research News

Image Source : INSTAGRAM/KEONESKINCARE

Eye Health: 5 ways to take care of your eyesight

Reduced eyesight is caused by multiple factors, including diseases like diabetes, eye trauma, cataracts or glaucoma. Over 3 crore individuals suffer from blindness globally, with India being home to nearly one-third the total figure. While 80 percent vision impairment can be prevented by early detection and timely intervention, lack of access and awareness has been a major deterrent in individuals seeking eye care.

Over 5 crore people in India have moderate to severe vision impairment which has impacted their personal and professional lives, says Ramesh Pillai, Chief Optometrist & Head of Training, Titan Company Ltd, Eyewear Business. "The onslaught of COVID-19 has also led to an increase in screen-time for people across ages and this has been a major factor in declining eye health. Eye care and eye health have become more of a necessity," he adds.

He suggests five simple and effective ways to ensure good eye health:

Wearing branded Sunglasses which offer 100 percent UV protection while outdoors can help protect your eyes from the harmful impact of UV rays and Cataract formation. Wearing the right spectacles for screen usage like anti-reflection lenses with Blue Coating is extremely important. The Blue coating helps in blocking the harmful blue violet and allows the essential blue turquoise to help the circadian rhythm and thereby maintain the sleep-wake cycle.

Eating leafy green vegetables such as spinach, kale and broccoli contain Lutein and zeaxanthin help prevent cataracts. Lutein also stimulates the growth of pigments that help block out harmful UV rays. Food rich in Vitamins C and E and zinc, reduce the risk of developing a condition called Age Related Macular Degeneration (ARMD). Antioxidants protect against sun damage. Good sources of antioxidants include egg yolk, yellow peppers, pumpkins, sweet potatoes, carrots, blueberries. Onions, shallots, garlic, capers contain sulphur, cysteine, and lecithin, which help against cataract formation.

Dry eyes are a major irritant, especially as the pollution gets worse day by day. Resting the eyes often and blinking moistens the eyes, reducing dryness and irritation. One can also use drops to help keep your eyes moist in case of excess dryness.

With an increase in screen-time becoming an inevitable reality, taking good care of your eyes is paramount. Use the 20-20-20 rule, by taking a 20 second screen break every 20 minutes to look at objects 20 feet away from you. Increase font size when reading on-screen, so that devices don't need to be too close to your eyes, and you don't have to squint. A clean screen boosts visibility, wipe your screen over at least once a day.

Getting your eyes tested by a qualified Optometrist or an Eye Doctor once every year is very important. Regular eye examinations help find any symptoms associated with eye strains and provide solutions for the same. Titan Eyeplus on the occasion of World Sight Day has introduced an initiative -- online screen testing. Take out 60 seconds and take a simple online eye screening test that will give you an indication whether you suffer from eyesight problems. Basis screening results, the brand requests all to visit an ophthalmologist or optician.

Fight against Coronavirus: Full coverage

Read the original post:
Eye Health: 5 ways to take care of your eyesight - India TV News

TENDRING has been revealed to be one of the worst areas for sight loss in the country, according to the latest data from the NHS.

Opticians website Book An Eye Test has compiled a list of the Top 10 places in the UK in which people have the poorest eyesight.

Sight loss is defined as being full or partial loss of sight, and temporary or permanent blindness, in one or both eyes.

North Norfolk tops the lists, with 5.45 per cent of people living with sight loss, but Tendring has also crept into the list with nearly 7,200 people with sight loss.

This makes the district the 9th worst area in the country for sight loss, with 4.84 per cent of its 145,000 residents living with poor vision.

Commenting on the findings, Katie Memory, director and managing partner at Memory Opticians, believes the results are not surprising given the average age of residents.

She said: The research shows that the places with the highest levels of sight loss are mainly situated in rural or coastal areas.

This is not surprising, as these areas are typically home to ageing populations, who often show higher rates of sight loss compared to younger generations, as sight loss increases gradually as we get older.

This also explains why, at the other end of the scale, large cities with younger populations such as London and Manchester contain fewer people suffering from sight loss.

You can view the full list by visiting bookaneyetest.co.uk/post/britains-vision.

Original post:
Here's the worst place in Essex for sight loss - Clacton and Frinton Gazette

UpMarketResearch publishes a detailed report on Eyesight Test Equipment market providing a complete information on the current market situation and offering robust insights about the potential size, volume, and dynamics of the market during the forecast period, 2020-2026. This report offers an in-depth analysis that includes the latest information including the current COVID-19 impact on the market and future assessment of the impact on Global Eyesight Test Equipment Market. The report contains XX pages, which will assist clients to make informed decision about their business investment plans and strategies for the market. As per the report by UpMarketResearch, the global Eyesight Test Equipment market is projected to reach a value of USDXX by the end of 2026 and grow at a CAGR of XX% during the forecast period.

Get FREE Exclusive PDF Sample Copy of This Report: https://www.upmarketresearch.com/home/requested_sample/51303

The Eyesight Test Equipment market report also covers an overview of the segments and sub-segmentations including the product types, applications, and regions. In the light of this harsh economic condition as prompted by the COVID-19 outbreak, the report studies the dynamics of the market, changing competition landscape, and the flow of the global supply and consumption.

The report exclusively deals with key areas such as market size, scope, and growth opportunities of the Eyesight Test Equipment market by analyzing the market trend and data available for the period from 2020-2026. Keeping 2019 as the base year for the research study, the report explains the key drivers as well as restraining factors, which are likely to have major impact on the development and expansion of the market during the forecast period.

The report, published by UpMarketResearch, is the most reliable information as the study relies on a concrete research methodology focusing on both primary as well as secondary sources. The report is prepared by relying on primary source including interviews of the company executives & representatives and accessing official documents, websites, and press release of the private and public companies.

The report, prepared by UpMarketResearch, is widely known for its accuracy and factual figures as it consists of a concise graphical representations, tables, and figures which displays a clear picture of the developments of the products and its market performance over the last few years. It uses statistical surveying for SWOT analysis, PESTLE analysis, predictive analysis, and real-time analytics.

Customize Report and Inquiry for the Eyesight Test Equipment market Report: https://www.upmarketresearch.com/home/enquiry_before_buying/51303

Furthermore, the scope of the growth potential, revenue growth, product range, and pricing factors related to the Eyesight Test Equipment market are thoroughly assessed in the report in a view to entail a broader picture of the market. The report also covers the recent agreements including merger & acquisition, partnership or joint venture and latest developments of the manufacturers to sustain in the global competition of the Eyesight Test Equipment market.

Competition Landscape:

The report covers global aspect of the market, covering

Global Eyesight Test Equipment market by Types:

PortableStationary

Global Eyesight Test Equipment market by Applications:

ChildrenAdults

Key Players for Global Eyesight Test Equipment market:

EyeNetraBhavana MDCEssilor InternationalAlcon Inc.HeineHeidelberg Engineering GmbHSeiko Optical Products Co. Ltd.Nidek Co. Ltd.Carl Zeiss AGHoya CorporationAbbott Medical Optics.Inc.Johnson & Johnson Vision Care.Inc.Shenzhen Certainn Technology

Avail the Discount on this report @ https://www.upmarketresearch.com/home/request_for_discount/51303

UpMarketResearch offers attractive discounts on customization of reports as per your need. This report can be personalized to meet your requirements. Get in touch with our sales team, who will guarantee you to get a report that suits your necessities.

About UpMarketResearch:

UpMarketResearch (https://www.upmarketresearch.com) is a leading distributor of market research report with more than 800+ global clients. As a market research company, we take pride in equipping our clients with insights and data that holds the power to truly make a difference to their business. Our mission is singular and well-defined we want to help our clients envisage their business environment so that they are able to make informed, strategic and therefore successful decisions for themselves.

Contact Info UpMarketResearchName Alex MathewsPhone No.: +1 909 545 6473Email [emailprotected]Website https://www.upmarketresearch.comAddress 500 East E Street, Ontario, CA 91764, United States.

The rest is here:
Eyesight Test Equipment Market 2019 | Analyzing The Impact Followed By Restraints, Opportunities And Projected Developments | UpMarketResearch -...

Prevent Blindness launches new awareness campaign, "Screen Time-Out," to help reduce the risk of digital eye strain.

CHICAGO (PRWEB) October 21, 2020

In response to increased virtual activity during the coronavirus pandemic, Prevent Blindness, the nation's leading volunteer eye health and safety organization dedicated to fighting blindness and saving sight, today launched Screen Time-Out, an awareness campaign to encourage Americans, especially parents of young children, to introduce regular screen breaks into their daily routines.

During work, school and even personal downtime, people spend as much as 12 hours a day in front of a digital screen. This amount of screen time exacerbates the risk of digital eye strain, also known as computer vision syndrome, especially for children whose eyes are still developing. Symptoms may include tired, burning or itching eyes, dry eyes, blurred vision and/or headache. The risk of digital eye strain has recently risen to a mounting level in the United States during the coronavirus pandemic, with 53 percent of respondents in a recent survey feeling burnout on screens over the last few months.

"At Prevent Blindness, we are concerned about people spending more and more time in front of our screens," said Jeff Todd, president and CEO of Prevent Blindness. "As an organization dedicated to ensuring everyone has a lifetime of healthy vision, the Screen Time-Out campaign is meant to educate people and reduce the risk of eye strain, starting with the youngest among us.

The Screen Time-Out campaign will live on social media Facebook, Instagram and Pinterest where device users are already spending a lot of their recreational screen time.

According to a recent survey of American eyecare professionals, 64 percent of respondents have seen an increase in patients having issues due to more screen time. Sixty-eight percent said they have seen those issues in both children and adults.

"Digital eye strain has been a rising modern threat to people of all ages, and it is linked to myriad issues, including eye development and nearsightedness," said Dr. Linda Chous, pediatric optometrist. "It is important now more than ever to be mindful of how much time we spend with screens and take steps to reduce the impact of digital eye strain."

To reduce eye strain, Prevent Blindness recommends children and adults take regular breaks using the 20-20-20 rule: every 20 minutes, shift eyes away from the screen to look at an object at least 20 feet away for at least 20 seconds.

Other tips to avoid eye strain from the American Academy of Ophthalmology include:

For more information about Screen Time-Out and Prevent Blindness, visit http://www.preventblindness.org/screen-time-out.

About Prevent BlindnessFounded in 1908, Prevent Blindness is the nation's leading volunteer eye health and safety organization dedicated to fighting blindness and saving sight. Focused on promoting a continuum of vision care, Prevent Blindness touches the lives of millions of people each year through public and professional education, advocacy, certified vision screening and training, community and patient service programs and research. These services are made possible through the generous support of the American public. Together with a network of affiliates, Prevent Blindness is committed to eliminating preventable blindness in America. For more information, or to make a contribution to the sight-saving fund, call 1-800-331-2020. Or, visit us on the Web at http://www.preventblindness.org or http://www.facebook.com/preventblindness.

Share article on social media or email:

More:
Prevent Blindness Encourages Everyone to Take a Screen Time-Out - PR Web

In Exosome Therapeutic Market report, a systematic investment analysis has been performed which forecasts impending opportunities for the market players. The statistical and numerical data that has been included in this market report is represented with the tables, graphs and charts which eases the understanding of facts and figures. A proficient data and excellent forecasting techniques used in this report are synonymous with accurateness and correctness. Exosome Therapeutic Market report is a painstaking analysis of existing scenario of the market which covers several market dynamics. The market study of this global Exosome Therapeutic Market business report takes into consideration market attractiveness analysis where each segment is benchmarked based on its market size, growth rate & general attractiveness.

Get Sample PDF (including COVID19 Impact Analysis) of Market Report @https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-exosome-therapeutic-market&rp

Market Analysis and Insights:Global Exosome Therapeutic Market

Exosome therapeutic market is expected to gain market growth in the forecast period of 2019 to 2026. Data Bridge Market Research analyses that the market is growing with a CAGR of 21.9% in the forecast period of 2019 to 2026 and expected to reach USD 31,691.52 million by 2026 from USD 6,500.00 million in 2018. Increasing prevalence of lyme disease, chronic inflammation, autoimmune disease and other chronic degenerative diseases are the factors for the market growth.

The major players covered in theExosome Therapeutic Marketreport areevox THERAPEUTICS, EXOCOBIO, Exopharm, AEGLE Therapeutics, United Therapeutics Corporation, Codiak BioSciences, Jazz Pharmaceuticals, Inc., Boehringer Ingelheim International GmbH, ReNeuron Group plc, Capricor Therapeutics, Avalon Globocare Corp., CREATIVE MEDICAL TECHNOLOGY HOLDINGS INC., Stem Cells Group among other players domestic and global.Exosome therapeutic market share data is available for Global, North America, Europe, Asia-Pacific, and Latin America separately. DBMR analysts understand competitive strengths and provide competitive analysis for each competitor separately.

Get Full TOC, Tables and Figures of Market Report @https://www.databridgemarketresearch.com/toc/?dbmr=global-exosome-therapeutic-market&rp

Exosomes are used to transfer RNA, DNA, and proteins to other cells in the body by making alteration in the function of the target cells. Increasing research activities in exosome therapeutic is augmenting the market growth as demand for exosome therapeutic has increased among healthcare professionals.

Increased number of exosome therapeutics as compared to the past few years will accelerate the market growth. Companies are receiving funding for exosome therapeutic research and clinical trials. For instance, In September 2018, EXOCOBIO has raised USD 27 million in its series B funding. The company has raised USD 46 million as series a funding in April 2017. The series B funding will help the company to set up GMP-compliant exosome industrial facilities to enhance production of exosomes to commercialize in cosmetics and pharmaceutical industry.

Increasing demand for anti-aging therapies will also drive the market. Unmet medical needs such as very few therapeutic are approved by the regulatory authority for the treatment in comparison to the demand in global exosome therapeutics market will hamper the market growth market. Availability of various exosome isolation and purification techniques is further creates new opportunities for exosome therapeutics as they will help company in isolation and purification of exosomes from dendritic cells, mesenchymal stem cells, blood, milk, body fluids, saliva, and urine and from others sources. Such policies support exosome therapeutic market growth in the forecast period to 2019-2026.

This exosome therapeutic market report provides details of market share, new developments, and product pipeline analysis, impact of domestic and localised market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, product approvals, strategic decisions, product launches, geographic expansions, and technological innovations in the market. To understand the analysis and the market scenario contact us for anAnalyst Brief, our team will help you create a revenue impact solution to achieve your desired goal.

Global Exosome Therapeutic Market Scope and Market Size

Global exosome therapeutic market is segmented of the basis of type, source, therapy, transporting capacity, application, route of administration and end user. The growth among segments helps you analyse niche pockets of growth and strategies to approach the market and determine your core application areas and the difference in your target markets.

Based on type, the market is segmented into natural exosomes and hybrid exosomes. Natural exosomes are dominating in the market because natural exosomes are used in various biological and pathological processes as well as natural exosomes has many advantages such as good biocompatibility and reduced clearance rate compare than hybrid exosomes.

Exosome is an extracellular vesicle which is released from cells, particularly from stem cells. Exosome functions as vehicle for particular proteins and genetic information and other cells. Exosome plays a vital role in the rejuvenation and communication of all the cells in our body while not themselves being cells at all. Research has projected that communication between cells is significant in maintenance of healthy cellular terrain. Chronic disease, age, genetic disorders and environmental factors can affect stem cells communication with other cells and can lead to distribution in the healing process. The growth of the global exosome therapeutic market reflects global and country-wide increase in prevalence of autoimmune disease, chronic inflammation, Lyme disease and chronic degenerative diseases, along with increasing demand for anti-aging therapies. Additionally major factors expected to contribute in growth of the global exosome therapeutic market in future are emerging therapeutic value of exosome, availability of various exosome isolation and purification techniques, technological advancements in exosome and rising healthcare infrastructure.

Rising demand of exosome therapeutic across the globe as exosome therapeutic is expected to be one of the most prominent therapies for autoimmune disease, chronic inflammation, Lyme disease and chronic degenerative diseases treatment, according to clinical researches exosomes help to processes regulation within the body during treatment of autoimmune disease, chronic inflammation, Lyme disease and chronic degenerative diseases. This factor has increased the research activities in exosome therapeutic development around the world for exosome therapeutic. Hence, this factor is leading the clinician and researches to shift towards exosome therapeutic. In the current scenario the exosome therapeutic are highly used in treatment of autoimmune disease, chronic inflammation, Lyme disease and chronic degenerative diseases and as anti-aging therapy as it Exosomes has proliferation of fibroblast cells which is significant in maintenance of skin elasticity and strength.

Based on source, the market is segmented into dendritic cells, mesenchymal stem cells, blood, milk, body fluids, saliva, urine and others. Mesenchymal stem cells are dominating in the market because mesenchymal stem cells (MSCs) are self-renewable, multipotent, easily manageable and customarily stretchy in vitro with exceptional genomic stability. Mesenchymal stem cells have a high capacity for genetic manipulation in vitro and also have good potential to produce. It is widely used in treatment of inflammatory and degenerative disease offspring cells encompassing the transgene after transplantation.

Based on therapy, the market is segmented into immunotherapy, gene therapy and chemotherapy. Chemotherapy is dominating in the market because chemotherapy is basically used in treatment of cancer which is major public health issues. The multidrug resistance (MDR) proteins and various tumors associated exosomes such as miRNA and IncRNA are include in in chemotherapy associated resistance.

Based on transporting capacity, the market is segmented into bio macromolecules and small molecules. Bio macromolecules are dominating in the market because bio macromolecules transmit particular biomolecular information and are basically investigated for their delicate properties such as biomarker source and delivery system.

Based on application, the market is segmented into oncology, neurology, metabolic disorders, cardiac disorders, blood disorders, inflammatory disorders, gynecology disorders, organ transplantation and others. Oncology segment is dominating in the market due to rising incidence of various cancers such as lung cancer, breast cancer, leukemia, skin cancer, lymphoma. As per the National Cancer Institute, in 2018 around 1,735,350 new cases of cancer was diagnosed in the U.S. As per the American Cancer Society Inc in 2019 approximately 268,600 new cases of breast cancer diagnosed in the U.S.

Based on route of administration, the market is segmented into oral and parenteral. Parenteral route is dominating in the market because it provides low drug concentration, free from first fast metabolism, low toxicity as compared to oral route as well as it is suitable in unconscious patients, complicated to swallow drug etc.

The exosome therapeutic market, by end user, is segmented into hospitals, diagnostic centers and research & academic institutes. Hospitals are dominating in the market because hospitals provide better treatment facilities and skilled staff as well as treatment available at affordable cost in government hospitals.

Exosome therapeutic Market Country Level Analysis

The global exosome therapeutic market is analysed and market size information is provided by country by type, source, therapy, transporting capacity, application, route of administration and end user as referenced above.

The countries covered in the exosome therapeutic market report are U.S. and Mexico in North America, Turkey in Europe, South Korea, Australia, Hong Kong in the Asia-Pacific, Argentina, Colombia, Peru, Chile, Ecuador, Venezuela, Panama, Dominican Republic, El Salvador, Paraguay, Costa Rica, Puerto Rico, Nicaragua, Uruguay as part of Latin America.

Country Level Analysis, By Type

North America dominates the exosome therapeutic market as the U.S. is leader in exosome therapeutic manufacturing as well as research activities required for exosome therapeutics. At present time Stem Cells Group holding shares around 60.00%. In addition global exosomes therapeutics manufacturers like EXOCOBIO, evox THERAPEUTICS and others are intensifying their efforts in China. The Europe region is expected to grow with the highest growth rate in the forecast period of 2019 to 2026 because of increasing research activities in exosome therapeutic by population.

The country section of the report also provides individual market impacting factors and changes in regulation in the market domestically that impacts the current and future trends of the market. Data points such as new sales, replacement sales, country demographics, regulatory acts and import-export tariffs are some of the major pointers used to forecast the market scenario for individual countries. Also, presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, impact of sales channels are considered while providing forecast analysis of the country data.

Huge Investment by Automakers for Exosome Therapeutics and New Technology Penetration

Global exosome therapeutic market also provides you with detailed market analysis for every country growth in pharma industry with exosome therapeutic sales, impact of technological development in exosome therapeutic and changes in regulatory scenarios with their support for the exosome therapeutic market. The data is available for historic period 2010 to 2017.

Competitive Landscape and Exosome Therapeutic Market Share Analysis

Global exosome therapeutic market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, company strengths and weaknesses, product launch, product trials pipelines, concept cars, product approvals, patents, product width and breadth, application dominance, technology lifeline curve. The above data points provided are only related to the companys focus related to global exosome therapeutic market.

Many joint ventures and developments are also initiated by the companies worldwide which are also accelerating the global exosome therapeutic market.

For instance,

Partnership, joint ventures and other strategies enhances the company market share with increased coverage and presence. It also provides the benefit for organisation to improve their offering for exosome therapeutics through expanded model range.

Customization Available:Global Exosome Therapeutic Market

Data Bridge Market Researchis a leader in advanced formative research. We take pride in servicing our existing and new customers with data and analysis that match and suits their goal. The report can be customised to include price trend analysis of target brands understanding the market for additional countries (ask for the list of countries), clinical trial results data, literature review, refurbished market and product base analysis. Market analysis of target competitors can be analysed from technology-based analysis to market portfolio strategies. We can add as many competitors that you require data about in the format and data style you are looking for. Our team of analysts can also provide you data in crude raw excel files pivot tables (Factbook) or can assist you in creating presentations from the data sets available in the report.

Do You Have Any Query Or Specific Requirement? Ask to Our Industry Expert @https://www.databridgemarketresearch.com/inquire-before-buying/?dbmr=global-exosome-therapeutic-market&rp

About Data Bridge Market Research :

Data Bridge Market Researchis a versatile market research and consulting firm with over 500 analysts working in different industries. We have catered more than 40% of the fortune 500 companies globally and have a network of more than 5000+ clientele around the globe. Our coverage of industries include Medical Devices, Pharmaceuticals, Biotechnology, Semiconductors, Machinery, Information and Communication Technology, Automobiles and Automotive, Chemical and Material, Packaging, Food and Beverages, Cosmetics, Specialty Chemicals, Fast Moving Consumer Goods, Robotics, among many others.

Data Bridge adepts in creating satisfied clients who reckon upon our services and rely on our hard work with certitude.We are content with our glorious 99.9 % client satisfying rate.

Contact Us :

Data Bridge Market Research

US: +1 888 387 2818

UK: +44 208 089 1725

Hong Kong: +852 8192 7475

Mail:[emailprotected]

Here is the original post:
Exosome Therapeutic Market 2020-2026 || Major Gaints Jazz Pharmaceuticals, Inc., Boehringer Ingelheim International GmbH, ReNeuron Group plc,...

High response rates were observed for patients with relapsed/refractory Hodgkin lymphoma treated with the combination of vorinostat and an mTOR inhibitor, according to findings published in Clinical Cancer Research.1

Although the majority of patients diagnosed with Hodgkin lymphoma are considered to be cured following first-line treatment with standard therapy, 5-year survival rates for those with relapsed/refractory disease following primary treatment can be as low as 30%.2

Despite US Food and Drug Administration (FDA) approvals of brentuximab, a CD30 antibody-drug conjugate, and the programmed cell death 1 (PD-1) inhibitors pembrolizumab and nivolumab for the treatment of patients with relapsed/refractory Hodgkin lymphoma, an unmet need remains for new therapies in this setting.

Based on prior preclinical and early clinical evidence supporting the potential efficacy of dual histone deacetylase (HDAC) and AKT/mTOR inhibition for those with relapsed/refractory Hodgkin lymphoma, the cohort of patients with heavily pretreated Hodgkin lymphoma enrolled in a nonrandomized, open-label, dose-escalation phase 1 study (ClinicalTrials.gov Identifier: NCT01087554) investigating the combination of vorinostat, an HDAC inhibitor, with an mTOR inhibitor in advanced cancer was expanded.

The rationale for such an approach was grounded in evidence implicating HDAC overexpression and associated aberrant gene expression in relapsed/refractory Hodgkin lymphoma, as well as a possible role for mTOR signaling as a pathway for resistance to HDAC inhibition in this setting.2,3

At baseline, the 40 patients included in this analysis were aged at least 18 years; the median patient age was 33 years. Regarding race/ethnicity, 55%, 27.5%, 12.5%, and 5% of these patients were White, Hispanic, Black, and Asian, respectively. Stage IV disease was present in 65% of patients, and Eastern Cooperative Oncology Group (ECOG) performance status was 0 (30%), 1 (50%), and 2 (20%). The median number of prior treatments was 5, with previous therapies including brentuximab vendotin, autologous hematopoietic stem cell transplantation (HSCT), and allogeneic HSCT in 97.5%, 65%, and 30% of patients, respectively.

None of these patients had received prior treatment with a PD-1 inhibitor.

Vorinostat, in combination with either siroliumus and everolimus, was administered to 22 and 18 patients, respectively.

For those patients treated with vorinostat plus siroliumus, the complete response (CR) and partial response (PR) rates were both 27%. At a median follow-up of 43.3 months, median progression-free survival (PFS) was 5.8 months.

In the subgroup receiving vorinostat plus everolimus, the CR and PR rates were 11% and 22%, respectively, and, at a median follow-up of 21 months, the median PFS was 4.8 months. A comparison of median PFS for those treated with either sirolimus or everolimus did not show a significant difference (P =.13)

Of note, responses were seen even in patients who received prior treatment with AKT or HDAC inhibitors, the study authors commented.

Regarding the safety of combination therapy with an HDAC and an mTOR inhibitor, the most commonly reported grade 3/4 adverse events (AEs) in the overall study population were neutropenia, thrombocytopenia, and anemia. However, while the frequencies of grade 4 neutropenia, thrombocytopenia, and anemia for those treated with sirolimus were 9%, 36%, and 0%, respectively, the corresponding rates were 0%, 11%, and 9% for the subgroup receiving everolimus. No treatment-related grade 5 AEs were reported.

In their concluding remarks, the study authors noted that combined HDAC and mTOR inhibition has encouraging activity in patients with relapsed and/or refractory Hodgkin lymphoma and warrants further investigation.

References

Continued here:
Promising, Early Results for Combined HDAC and mTOR Inhibition in Relapsed/Refractory Hodgkin Lymphoma - Cancer Therapy Advisor

DENVER A baby broken, inside the womb.

Most doctors gave little unborn Payton Calvillo any hope she would survive. But through strong faith and the help of a team of medical experts, she is thriving today.

"She's a complete miracle baby," said Payton's mother, Ahna Calvillo.

When Ahna was just five months pregnant, she was told her unborn baby would probably not survive birth.

"It was pretty much a death sentence from the beginning."

Payton's bones were breaking and bending inside the womb.

"She likely had a problem where she couldn't make alkaline phosphatase properly," explained Dr. Sunil Nayak, a pediatric endocrinologist at Rocky Mountain Hospital for Children.

Alkaline phosphatase is needed for bones to grow and strengthen and there was little anyone could do.

Nineteen different specialists were on hand for the C-section delivery

"They even asked us the question that morning, how far do you want us to go?" Ahna remembered. "'Do you want a ventilator on her?', you know, 'How far do you want us to prolong her life?' Our ultimate hope and goal was that she would come out and breathe on her own."

"She just came out screaming," said Ahna. "She came out crying. She breathed on her own right away. She was perfect."

Payton was diagnosed with hypophosphatasia, a disorder that weakens bones and was immediately placed on a new FDA-approved medicine.

"Here we are just one year later at one year of age and you see a dramatic difference in the shape," said Dr. Jared Riley, a pediatric orthopedic surgeon at Rocky Mountain Hospital.

Before the medicine, 75% of all patients died by the age of five.

Now there is a 97% chance Payton will live a normal life.

"My baby was broken and that's what I needed God to do was a miracle," said Ahna.

One was also treated with bone fragments and cultured osteoblasts, which are bone-forming cells.

"Cultured" refers to cells that are grown under specific conditions outside of the natural environment (the body) and within a laboratory.

Both patients showed significant, but incomplete improvement, although no more formal studies have been conducted.

Then, the drug teriparatide (parathyroid hormone 1-34) has been given "off-label" to several adults with HPP with metatarsal stress fractures or femoral pseudo fractures, resulting in healing.

The drug is not permitted for use in children.

More research is necessary to determine the long-term safety and effectiveness of teriparatide in the treatment of HPP.

Every year eight million babies are born with genetic disorders passed down from generation to generation.

Payton will stay on the new medication for the next few years and then doctors will re-evaluate whether she needs to continue.

Payton's family didn't even know they carried the problematic HPP gene until an ultrasound revealed it in their unborn baby.

After being genetically tested, Payton's mother and grandfather are positive.

Neither one has ever suffered from weak or broken bones.

If this story has impacted your life or prompted you or someone you know to seek or change treatments, please let us know by contacting Jim Mertens atjim.mertens@wqad.comor Marjorie Bekaert Thomas atmthomas@ivanhoe.com.

Continued here:
YOUR HEALTH: Saving an unborn baby breaking apart in the womb - WQAD.com