StemCell Therapy

AMR information of the Global Agricultural Biotechnology Market report will surely grow business and improve return on investment (ROI). The report has been prepared by taking into account several aspects of marketing research and analysis which includes market size estimations, market dynamics, company & market best practices, entry level marketing strategies, positioning and segmentations, competitive landscaping, opportunity analysis, economic forecasting, industry-specific technology solutions, roadmap analysis, targeting key buying criteria, and in-depth benchmarking of vendor offerings. This Agricultural Biotechnology Market research report gives CAGR values along with its fluctuations for the specific forecast period.

Major Market Key Players: Agricultural Biotechnology Market

Syngenta AG, Monsanto, DuPont, Performance Plants Inc., Global Bio-Chem Technology Group, and ADAMA Agricultural Solutions are some of the key players in this industry

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Agricultural Biotechnology Market research report encompasses a far-reaching research on the current conditions of the industry, potential of the market in the present and the future prospects. By taking into account strategic profiling of key players in the industry, comprehensively analyzing their core competencies, and their strategies such as new product launches, expansions, agreements, joint ventures, partnerships, and acquisitions, the report helps businesses improve their strategies to sell goods and services. This AMR research report is sure to help grow your business in several ways. Hence, the Agricultural Biotechnology Market report brings into the focus, the more important aspects of the market or industry.

The Global Agricultural Biotechnology Market Accounted For XXX USD Billion In 2017 And Is Projected To Grow At A CAGR Of XX% The Forecast Period Of 2018 To 2025. The Upcoming Market Report Contains Data For Historic Years 2016, The Base Year Of Calculation Is 2017 And The Forecast Period Is 2018 To 2025.

This Free report sample includes:

1.A brief introduction to the Agricultural Biotechnology Market research report.2.Graphical introduction of the regional analysis.3.Top players in the Agricultural Biotechnology Market with their revenue analysis.4.Selected illustrations of Agricultural Biotechnology Market insights and trends.5.Example pages from the Agricultural Biotechnology Market

The Agricultural Biotechnology Market report provides insights on the following pointers:1.Market Penetration: Comprehensive information on the product portfolios of the top players in the Agricultural Biotechnology Market.

2.Product Development/Innovation: Detailed insights on the upcoming technologies, R&D activities, and product launches in the market.

3.Competitive Assessment: In-depth assessment of the market strategies, geographic and business segments of the leading players in the market.

4.Market Development: Comprehensive information about emerging markets. This report analyses the market for various segments across geographies.

5.Market Diversification: Exhaustive information about new products, untapped geographies, recent developments, and investments in the Agricultural Biotechnology Market.

Table of Contents: Agricultural Biotechnology Market*Agricultural Biotechnology Market Overview*Global Economic Impact on Industry*Global Market Competition by Manufacturers*Global Production, Revenue (Value) by Region*Global Supply (Production), Consumption, Export, Import by Regions*Global Production, Revenue (Value), Price Trend by Type*Global Market Analysis by Application*Manufacturing Cost Analysis*Industrial Chain, Sourcing Strategy and Downstream Buyers*Marketing Strategy Analysis, Distributors/Traders*Market Effect Factors Analysis*Global Agricultural Biotechnology Market Forecast

Get Latest Free TOC of This Report @ https://www.adroitmarketresearch.com/industry-reports/agricultural-biotechnology-market

Some of the key questions answered in these Agricultural Biotechnology Market reports:

*What will the market growth rate, growth momentum or acceleration market carries during the forecast period?*Which are the key factors driving the Agricultural Biotechnology Market?*What was the size of the emerging Agricultural Biotechnology Market by value in 2019?*What will be the size of the emerging Agricultural Biotechnology Market in 2025?*Which region is expected to hold the highest market share in the Agricultural Biotechnology Market?*What trends, challenges and barriers will impact the development and sizing of the Global Agricultural Biotechnology Market?*What is sales volume, revenue, and price analysis of top manufacturers of Agricultural Biotechnology Market?*What are the Agricultural Biotechnology Market opportunities and threats faced by the vendors in the global Agricultural Biotechnology Market Industry?

With tables and figures helping analyze worldwide Global Agricultural Biotechnology Market growth factors, this research provides key statistics on the state of the industry and is a valuable source of guidance and direction for companies and individuals interested in the market.

How will this Market Intelligence Report Benefit You?

1.The report offers statistical data in terms of value (US$) as well as Volume (units) till 2027.

2.Exclusive insight into the key trends affecting the Agricultural Biotechnology industry, although key threats, opportunities and disruptive technologies that could shape the Global Agricultural Biotechnology Market supply and demand.

3.The report tracks the leading market players that will shape and impact the Global Agricultural Biotechnology Market most.

4.The data analysis present in the Agricultural Biotechnology report is based on the combination of both primary and secondary resources.

5.The report helps you to understand the real effects of key market drivers or retainers on Agricultural Biotechnology business.Significant highlights covered in the Global Agricultural Biotechnology market include:

*In-depth market analysis, including information about current Agricultural Biotechnology market drivers and challenges

*An exhaustive study on the expected trends, changing market dynamics, and market intelligence

*Porters Five Forces analysis discussing the potentiality of buyers and sellers operating in the market, which is likely to help in developing efficient strategies

*Detailed analysis of the changing competitive scenario and thorough vendor analysis

Some Notable Report Offerings:

We will provide you an analysis of the extent to which the global Agricultural Biotechnology acquires commercial characteristics along with examples or instances of information that helps you to understand it better.

We will also help to identify customary/ standard terms and conditions, as like offers, worthiness, warranty, and others for the Agricultural Biotechnology industry.

Also, this report will help you to identify any trends to forecast Agricultural Biotechnology growth rates.

The analysed report will forecast the general tendency for supply and demand in Agricultural Biotechnology market.

Thanks for reading this article you can also get individual chapter wise section or region wise report version like North America, Europe, MEA or Asia Pacific.

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About Us :

Adroit Market Research is an India-based business analytics and consulting company incorporated in 2018. Our target audience is a wide range of corporations, manufacturing companies, product/technology development institutions and industry associations that require understanding of a markets size, key trends, participants and future outlook of an industry. We intend to become our clients knowledge partner and provide them with valuable market insights to help create opportunities that increase their revenues. We follow a code Explore, Learn and Transform. At our core, we are curious people who love to identify and understand industry patterns, create an insightful study around our findings and churn out money-making roadmaps.

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Ryan JohnsonAccount Manager Global3131 McKinney Ave Ste 600, Dallas,TX75204, U.S.A.Phone No.: USA: +1 972-362 -8199/ +91 9665341414

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Agricultural Biotechnology Market (COVID-19 Analysis): Major Applications Projected to be the Most Attractive Segment during 2020-2027 - Cheshire...

Aimed at decoding specific market developments and forces ensuring sustainable growth in Global Food Biotechnology Market, new business intelligence report has been recently added to equip report readers, investors and manufacturing veterans with ample insights crucial to harness growth prognosis. The report gauges into historical events and identifies core growth steering practices adopted in the historical years to propagate revenue generation. Based on current status and optimum understanding on past developments, keen market investors and novel aspirants may well brainstorm lucrative business strategies to sustain long term growth and stability in Global Food Biotechnology Market.

Get a sample of the report @ https://www.orbisresearch.com/contacts/request-sample/5304247?utm_source=Manjiri

Core Indicator Analysis: Global Food Biotechnology MarketCompetitive Landscape: Besides identifying some the primary forerunners in the competition, this high end research report highlights details on top investor activities comprising product expansion, facility and technological improvements, R&D expeditions, pipeline investments as well as overall advertising and promotional investments that play crucial role in growth maximization and revenue sustenance amidst dynamics volatility.

Details pertaining to company profiles, product specifications, capacity and sales-based developments as well as pricing structure and revenue potential of each of the players reveal crucial market specific information that in turn influence mindful business decisions.

The Major Players Covered in Global Food Biotechnology Market are:ABS GlobalArcadia BiosciencesAquaBounty TechnologiesBASF Plant ScienceBayer CropScience AGCamson Bio Technologies LtdDow AgroSciences LLCDuPont PioneerEvogene LtdHy-Line InternationalKWS GroupMonsantoOrigin Agritech LimitedSyngenta AG

Global Food Biotechnology Market by Type:

Transgenic CropsSynthetic Biology Derived Products

Global Food Biotechnology Market by Application:

AnimalsPlantsOthers

Market segment by Regions/Countries, this report coversUnited StatesEuropeChinaJapanSoutheast AsiaIndiaCentral & South America

Read complete report @ https://www.orbisresearch.com/reports/index/covid-19-version-global-food-biotechnology-market-status-2015-2019-and-forecast-2020-2025-by-region-product-type-and-end-use?utm_source=Manjiri

Region-wise DevelopmentsAssessing the market through the growth span, 2020-25, this high-end report reflects past market developments and events besides identifying current events and trends that collectively aid in making accurate growth forecasts. Details on import and export potential as well as sales volume have been requisitely addressed in the report.

Regional assessment reveals details pertaining to growth status across specific growth spots, highlighting production and consumption developments, import and export activities as well as sales volume data that are crucial to render growth specific, high revenue incurring business decisions.

Segmentation by Product and ApplicationThis part of the report highlights versatile details on product improvisation, specifications aligning with customer expectations as well as volumetric growth advances. A clear perspective on application-based analysis of the Global Food Biotechnology Market has also been roped in the report to understand market size projections and dominant trend assessment that closely influence application derivatives.

The market also includes a detailed opportunity mapping section and driver assessment that result in systematic growth projections in Global Food Biotechnology Market.

For Enquiry before buying report @ https://www.orbisresearch.com/contacts/enquiry-before-buying/5304247?utm_source=Manjiri

Key Player Analysis

The report also includes a clear perspective on vendor activities and accurately identifies frontline players. Details on their product and service-based investments, bargaining power, manufacturing practices and revenue generation patterns have also been decisively scanned to derive workable insights. Information thus furnished in these report sections are aimed at directing profitable business decisions amongst keen market investors as well as novice entrants eying systematic market entry.

COVID Assessment

Aimed at delivering appropriate details on concurrent market developments and growth initiators, a dedicated section on COVID-19 analysis has also been included in the report to offer appropriate pandemic management guidelines.

About Us:Orbis Research (orbisresearch.com) is a single point aid for all your market research requirements. We have vast database of reports from the leading publishers and authors across the globe. We specialize in delivering customized reports as per the requirements of our clients. We have complete information about our publishers and hence are sure about the accuracy of the industries and verticals of their specialization. This helps our clients to map their needs and we produce the perfect required market research study for our clients.

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Global Food Biotechnology Market Industry Analysis and Forecast (2020-2025), By Material Type, Product Type, Application, and Region. - Cheshire...

Global Plant Biotechnology Equipment Market 2025 Report Provides Porters Five Forces Analysis Illustrates the Potency of Buyers & Suppliers Operating in the Industry & the Quantitative Analysis of The Global Market from 2019 to 2025 is Provided to Determine the Market Potential.

Plant Biotechnology Equipment Market Data and Acquisition Research Study with Trends and Opportunities 2019-2025The study of Plant Biotechnology Equipment market is a compilation of the market of Plant Biotechnology Equipment broken down into its entirety on the basis of types, application, trends and opportunities, mergers and acquisitions, drivers and restraints, and a global outreach. The detailed study also offers a board interpretation of the Plant Biotechnology Equipment industry from a variety of data points that are collected through reputable and verified sources. Furthermore, the study sheds a lights on a market interpretations on a global scale which is further distributed through distribution channels, generated incomes sources and a marginalized market space where most trade occurs.

Request a sample of Plant Biotechnology Equipment Market report @ https://hongchunresearch.com/request-a-sample/60575

Along with a generalized market study, the report also consists of the risks that are often neglected when it comes to the Plant Biotechnology Equipment industry in a comprehensive manner. The study is also divided in an analytical space where the forecast is predicted through a primary and secondary research methodologies along with an in-house model.

The following manufacturers are covered:Keygene(Netherlands)Heinz Walz GmbH (Germany)LemnaTec(Germany)Photon Systems Instruments(Czech Republic)Qubit Systems (Canada)Thermo Fisher Scientific (US)Tecan Group (Switzerland)LabRepCo (US)Geneq (Canada)Illumina (US)LGC Limited (UK)Evogene (Israel)

Access this report Plant Biotechnology Equipment Market @https://hongchunresearch.com/report/worldwide-plant-biotechnology-equipment-market-2019-60575

Segment by RegionsNorth AmericaEuropeChinaJapan

Segment by TypeSensors ModulesImaging DevicesAutomated SystemDronesLED LightingPortable Devices

Segment by ApplicationPlant ResearchBreedingProduct DevelopmentQuality AssessmentOthers

For a global outreach, the Plant Biotechnology Equipment study also classifies the market into a global distribution where key market demographics are established based on the majority of the market share. The following markets that are often considered for establishing a global outreach are North America, Europe, Asia, and the Rest of the World. Depending on the study, the following markets are often interchanged, added, or excluded as certain markets only adhere to certain products and needs.

Here is a short glance at what the study actually encompasses:Study includes strategic developments, latest product launches, regional growth markers and mergers & acquisitionsRevenue, cost price, capacity & utilizations, import/export rates and market shareForecast predictions are generated from analytical data sources and calculated through a series of in-house processes.

However, based on requirements, this report could be customized for specific regions and countries.

To Check Discount of Plant Biotechnology Equipment Market @ https://hongchunresearch.com/check-discount/60575

Major Point of TOC:

Chapter One: Plant Biotechnology Equipment Market Overview

Chapter Two: Global Plant Biotechnology Equipment Market Competition by Manufacturers

Chapter Three: Global Plant Biotechnology Equipment Production Market Share by Regions

Chapter Four: Global Plant Biotechnology Equipment Consumption by Regions

Chapter Five: Global Plant Biotechnology Equipment Production, Revenue, Price Trend by Type

Chapter Six: Global Plant Biotechnology Equipment Market Analysis by Applications

Chapter Seven: Company Profiles and Key Figures in Plant Biotechnology Equipment Business

Chapter Eight: Plant Biotechnology Equipment Manufacturing Cost Analysis

Chapter Nine: Marketing Channel, Distributors and Customers

Chapter Ten: Market Dynamics

Chapter Eleven: Global Plant Biotechnology Equipment Market Forecast

Chapter Twelve: Research Findings and Conclusion

Chapter Thirteen: Methodology and Data Source 13.1 Methodology/Research Approach13.1.1 Research Programs/Design13.1.2 Market Size Estimation13.1.3 Market Breakdown and Data Triangulation13.2 Data Source13.2.1 Secondary Sources13.2.2 Primary Sources13.3 Author List13.4 Disclaimer

About HongChun Research:HongChun Research main aim is to assist our clients in order to give a detailed perspective on the current market trends and build long-lasting connections with our clientele. Our studies are designed to provide solid quantitative facts combined with strategic industrial insights that are acquired from proprietary sources and an in-house model.

Contact Details:Jennifer GrayManager Global Sales+ 852 8170 0792[emailprotected]

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Impact Of Covid-19 on Plant Biotechnology Equipment Market 2020 Industry Challenges, Business Overview and Forecast Research Study 2026 - Cheshire...

Precision medicine is in its nascent stages, but the field is rapidly growing, adding another catalyst to an already lengthy list for the ARK Genomic Revolution Multi-Sector Fund (CBOE: ARKG).

One of the driving forces behind ARKGs enviable long-term track records is its the managers ability to identify disruptive forces in the healthcare and genomics arenas. The intersection of precision medicine and genomics could be the next growth frontier for ARKG investors.

Put simply, precision medicine is the application of technology to biology, and its one of the most innovative ideas in the healthcare arena.

Many precision-medicine techniques offer the potential for disease prevention, driving the potential for cost savings and patient-outcome improvements, said Dr. Charles Kennedy, CEO and managing partner at Blue Ox Healthcare Partners, in an interview with Barrons. One example is pre-term birth, which represents more than $32 billion in health-care spending in the U.S.in part due to its occurrence in one in every 10 pregnancies, and as many as one in every five pregnancies in the African American population. While many interventions are used to reduce the morbidity and mortality of pre-term birth, a fundamental problem that exists is the inability to identify women at risk for a pre-term delivery.

The intersection of precision medicine and genomics could be the next growth frontier for ARKG investors.

Everything about health care is changing and will continue to do so. Where you receive your care is evolving based on convenience and integration with daily life, said Kennedy. For example, weve seen more medical retail locations in shopping environments. Additionally, technology that remotely monitors patients who might otherwise need to be in a care setting is changing.

Gene sequencing and precision medicine are viewed as vital avenues for success in developing COVID-19 treatments. Bolstering the long-term case for genetic sequencing is the fields ability to help healthcare professionals more accurately diagnose ailments, delivering a higher level of personalized patient care.

While precision medicine might have only indirect impacts on issues such as access and costs, it transcends race by digitizing your biology and characterizing what makes you uniquely you, notes Kennedy in the Barrons interview. Simply put, you have the biology to take advantage of a drug or other treatment, or you dont. As such, more quantitative and discrete measures of disease and intervention opportunities make care more objective, less subjective, and more precisely aligned with the greatest likelihood of the best patient outcome, no matter who you are or where you come from.

For more on disruptive technologies, visit our Disruptive Technology Channel.

The opinions and forecasts expressed herein are solely those of Tom Lydon, and may not actually come to pass. Information on this site should not be used or construed as an offer to sell, a solicitation of an offer to buy, or a recommendation for any product.

Read more here:
How Precision Medicine Will Revolutionize Healthcare - ETF Trends

Study will expand access to antibody testing outside of laboratory settings

At present,mostantibody tests on the market require samples to be sent to a lab for analysis.The extra cost and time associated hasconstrainedpopulation wide studies ofSARS-CoV-2antibodies.

"An antibody test that can be done at the point of care without the need for a lab can more quickly provide information clinicians and administrators need to make decisions for their nursing home patients and staff," says Dr. Michael Fang, BASE10 CEO.

"This research is an important milestone in our efforts to expand access to antibody testing," says Elizabeth Freund, VP of Innovation at BASE10. "DNA Link's AccuFind performs very well in laboratory settings. The next logical step is to test its performance when used by healthcare professionals outside the lab. Many factors have the potential to affect test performance in lesser controlled settings so it's an ambitious goal to be sure. However, if FDA believes the data demonstrates its safety and effectiveness under these conditions, we'll be one step closer to FDA emergency use authorization for point of care use."

The study is set to launch in December.

About BASE10 Genetics, Inc.BASE10 is a precision medicine company based in Chicago. BASE10's proprietary platform identifies precision diagnostics technologies with high potential for improving health outcomes, and creates turnkey, disease management programs that can be deployed at scale for insurance payors.

For more information about BASE10 Genetics and its solutions, contact [emailprotected].

About DNA Link, Inc.DNA Link, Inc. is a leading genomic service corporation based in Korea with a focus on personalized medicine and new drug development. The company combines biotechnology with information & communications technology to support total analysis of genomic and clinical information to accelerate research and development in the field of bio-industry and genomic analysis industry.

For more information about DNA Link and its solutions, contact[emailprotected]

SOURCE BASE10 Genetics, Inc.

https://www.base10genetics.com/

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BASE10 and DNA Link Partners on Research to Support Authorization of Antibody Test at the Point of Care - PRNewswire

Parsippany, NJ, Nov. 25, 2020 (GLOBE NEWSWIRE) -- Interpace Biosciences, Inc. (NASDAQ: IDXG) today announced that Jack Stover, President & Chief Executive Officer, will retire effective December 31, 2020. He will be replaced as President and Chief Executive Officer by Thomas Burnell, PhD., effective December 1, 2020. Mr. Stover, who will step down from the Interpace Board of Directors once Dr. Burnell joins the company and is appointed to the Board, will serve as an advisor to the company through the middle of 2021 in order to support the transition.

Dr. Burnell joins Interpace with significant leadership experience with numerous healthcare companies, including a number of specialty clinical laboratories. This includes serving as President & CEO of Boston Heart Diagnostics, Viracor-IBT Laboratories and Eurofins Scientific, Inc. in addition to senior leadership roles with other companies such as Elite One Source, Nebraska Heart Institute, and most recently with the Pioneer Heart Institute.

Robert Gorman, Chairman of the Board for Interpace, commented, On behalf of the Board, I thank Jack for his leadership and service to the company. He has led the company through both difficult and transformational times, and has helped to position the company for strong growth in the future.

After careful reflection, I have decided that now is the right time to retire and help the company through a thoughtful succession process, said Mr. Stover. It has been a privilege to lead Interpace over the past four years, and I am proud to have been a part of the phenomenal team of dedicated professionals at Interpace which has worked tirelessly to improve the care of patients suspected of having cancer.

Dr. Burnell added, I am thrilled to join the Interpace team at such an exciting and pivotal point in the companys history. Interpace has a strong reputation as a patient-centric organization, and over the years has developed an impressive product and service offering that is particularly critical given the challenging demands of cancer care. I look forward to working with the entire leadership team to continue the companys growth as a leading provider of specialty oncology-focused diagnostic services and customized pharma services.

About Interpace Biosciences

Interpace Biosciences is an emerging leader in enabling personalized medicine, offering specialized services along the therapeutic value chain from early diagnosis and prognostic planning to targeted therapeutic applications.

Clinical services, through Interpace Diagnostics, provides clinically useful molecular diagnostic tests, bioinformatics and pathology services for evaluating risk of cancer by leveraging the latest technology in personalized medicine for improved patient diagnosis and management. Interpace has four commercialized molecular tests and one test in a clinical evaluation process (CEP): PancraGEN for the diagnosis and prognosis of pancreatic cancer from pancreatic cysts; ThyGeNEXT for the diagnosis of thyroid cancer from thyroid nodules utilizing a next generation sequencing assay; ThyraMIR for the diagnosis of thyroid cancer from thyroid nodules utilizing a proprietary gene expression assay; and RespriDX that differentiates lung cancer of primary vs. metastatic origin. In addition, BarreGEN for Barretts Esophagus, is currently in a clinical evaluation program whereby we gather information from physicians using BarreGEN to assist us in positioning the product for full launch, partnering and potentially supporting reimbursement with payers.

Pharma services, through Interpace Pharma Solutions, provides pharmacogenomics testing, genotyping, biorepository and other customized services to the pharmaceutical and biotech industries. Pharma services also advance personalized medicine by partnering with pharmaceutical, academic, and technology leaders to effectively integrate pharmacogenomics into their drug development and clinical trial programs with the goals of delivering safer, more effective drugs to market more quickly, and improving patient care.

For more information, please visit Interpace Biosciences website at http://www.interpace.com.

Forward-looking Statements

This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995, relating to the Companys future financial and operating performance. The Company has attempted to identify forward looking statements by terminology including believes, estimates, anticipates, expects, plans, projects, intends, potential, may, could, might, will, should, approximately or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. These statements are based on current expectations, assumptions and uncertainties involving judgments about, among other things, future economic, competitive and market conditions and future business decisions, all of which are difficult or impossible to predict accurately and many of which are beyond the Companys control. These statements also involve known and unknown risks, uncertainties and other factors that may cause the Companys actual results to be materially different from those expressed or implied by any forward-looking statement. Additionally, all forward-looking statements are subject to the Risk Factors detailed from time to time in the Companys most recent Annual Report on Form 10-K filed on April 22, 2020, Current Reports on Form 8-K and Quarterly Reports on Form 10-Q. Because of these and other risks, uncertainties and assumptions, undue reliance should not be placed on these forward-looking statements. In addition, these statements speak only as of the date of this press release and, except as may be required by law, the Company undertakes no obligation to revise or update publicly any forward-looking statements for any reason.

Contacts:Investor RelationsEdison GroupJoseph Green/ Megan Paul(646) 653-7030 / 7034jgreen@edisongroup.com / mpaul@edisongroup.com

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Interpace Biosciences Announces Executive Transition: Jack Stover to Retire as President and Chief Executive Officer Thomas Burnell Appointed as...

DUBLIN--(BUSINESS WIRE)--The "Growth Opportunities in Gene Therapy, Automated Bioanalytics, and Biomarker Platforms" report has been added to ResearchAndMarkets.com's offering.

The research provides technological insights across inflammation, infectious diseases, and microbiomics.

The Life Science, Health & Wellness TOE will feature disruptive technology advances in the global life sciences industry. The technologies and innovations profiled will encompass developments across genetic engineering, drug discovery and development, biomarkers, tissue engineering, synthetic biology, microbiome, disease management, as well as health and wellness among several other platforms.

The Health & Wellness cluster tracks developments in a myriad of areas including genetic engineering, regenerative medicine, drug discovery and development, nanomedicine, nutrition, cosmetic procedures, pain and disease management and therapies, drug delivery, personalized medicine, and smart healthcare.

Innovations in Life Sciences, Health & Wellness from:

For more information about this report visit https://www.researchandmarkets.com/r/tkufmb

Continued here:
2020 Report: Growth Opportunities in Gene Therapy, Automated Bioanalytics, and Biomarker Platforms - ResearchAndMarkets.com - Business Wire

Precision-Medicine-MarketOverview of Precision Medicine Market 2020-2026:

Global Precision Medicine Market 2020 research report presents analysis of market size, share, and growth, trends, cost structure, statistical and comprehensive data of the global market. Research reports analyses the major opportunities, CAGR, yearly growth rates to help the readers to understand the qualitative and quantitative aspects of theGlobal Precision MedicineMarket. The competition landscape, company overview, financials, recent developments and long-term investments related to theGlobal Precision Medicine Marketare mentioned in this report.

The key segments covered in this report are geographical segments, end-use/application segments, and competitor segments. The local segment, regional supply, application, and wise demand, major players, prices are also available by 2026. Global Precision Medicine Market are mentioned in the competition landscape, company overview, financials, recent developments and long-term investments.

Get PDF Sample Copy of the Report (Including Full TOC, List of Tables & Figures, Chart):https://www.marketinforeports.com/Market-Reports/Request-Sample/217480

Top Key players profiled in the Precision Medicine market report include:Johnson & Johnson, IBM, GE Healthcare, Illumina, Roche, Laboratory Corporation of America Holdings, Thermo Fisher Scientific, Novartis, Abbott Laboratories, Almac Group, Intel Corporation, Biomrieux Sa, Cepheid, Qiagen, Randox Laboratories, Healthcore and More

Based on the type of product, the global Precision Medicine market segmented into: Diagnostics TherapiesBased on the end-use, the global Precision Medicine market classified into: Oncology Neurosciences Immunology Respiratory Others

global Precision Medicine market report also highlights key insights on the factors that drive the growth of the market as well as key challenges that are required to Precision Medicine market growth in the projection period. Here provide the perspectives for the impact of COVID-19 from the long and short term. Precision Medicine market contain the influence of the crisis on the industry chain, especially for marketing channels. Update the industry economic revitalization plan of the country-wise government.

To Understand the influence of COVID-19 on the Set Screw Market with our analysts monitoring the situation across the globe. Get here sample analysis

Years Considered to Estimate the Market Size:History Year: 2015-2019Base Year: 2019Estimated Year: 2020Forecast Year: 2020-2026Regions Covered in the Global Precision Medicine Market:The Middle East and Africa(GCC Countries and Egypt)North America(the United States, Mexico, and Canada)South America(Brazil etc.)Europe(Turkey, Germany, Russia UK, Italy, France, etc.)Asia-Pacific(Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)

Key questions answered in this report:

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Key point summary of the Global Precision Medicine Market report:

Detailed TOC of Precision Medicine Market Report 2020-2026:Chapter 1: Precision Medicine Market OverviewChapter 2: Economic Impact on IndustryChapter 3: Market Competition by ManufacturersChapter 4: Production, Revenue (Value) by RegionChapter 5: Supply (Production), Consumption, Export, Import by RegionsChapter 6: Production, Revenue (Value), Price Trend by TypeChapter 7: Market Analysis by ApplicationChapter 8: Manufacturing Cost AnalysisChapter 9: Industrial Chain, Sourcing Strategy and Downstream BuyersChapter 10: Marketing Strategy Analysis, Distributors/TradersChapter 11: Market Effect Factors AnalysisChapter 12: Precision Medicine Market ForecastContinued

For More Information with full TOC: https://www.marketinforeports.com/Market-Reports/217480/Precision-Medicine-market

Customization of the Report: Market Info Reports provides customization of reports as per your need. This report can be personalized to meet your requirements. Get in touch with our sales team, who will guarantee you to get a report that suits your necessities.

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Latest Research report on Precision Medicine Market Size predicts favorable growth and forecast 2020 2026| By Top Leading Vendors like Johnson &...

Nov. 23, 2020 08:00 UTC

GHENT, Belgium--(BUSINESS WIRE)-- Novalis Biotech, an early stage venture capital investor in technologies to revolutionize healthcare, announced today the successful first closing of its second fund, Novalis Biotech Acceleration, raising an initial 8 million. With commitments for a similar amount already in place, Novalis anticipates a final closing in early 2021. The majority of investors in Novalis first fund have co-invested in this first closing.

We have already doubled our first fund in this closing and with the commitments in place we are almost fully subscribed to reach our goal of 25 million. With the addition of a couple new investors, we remain on track to fully close the Acceleration Fund in early 2021, said Jan Van den Berghe, co-founder of Novalis.

For the Novalis Acceleration Fund, investments will be split between approximately 10 early stage incubation projects and about 10 acceleration projects, where the investment in each company is larger. Two initial investments have been identified and will close in the near future.

Novalis investment strategy creates a unique ecosystem for healthcare start-ups based on solid foundations of strong scientific and business expertise. The company provides hands-on support for start-ups, allowing an idea to be built into a successful company. In todays disruptive world of new technologies in healthcare like genomics, bioinformatics, diagnostics, personalized medicine, Novalis vision is to bring better healthcare for patients.

Novalis invests early and focuses on capital light ideas, where a relatively small investment can create significant value through the use of software, IP, tools, and other technology that can serve and benefit healthcare. Leveraging extensive academic networks, Novalis translates innovation to viable companies that able to deliver on the founding scientific promise.

Our investment strategy for Fund 1 was very successful. Each company brings a unique perspective to healthcare, many of which are based on our own ideas, said Wim van Criekinge. We will continue this strategy into the Acceleration Fund as well as look at companies where our investment will drive process. There are already a number of companies we have identified for investment as well as plans to incubate a further company based on our internal assessments.

Novalis Fund 1 totalled 4 million that was deployed into eight companies, mostly in the Benelux region, which focused on genomics, bioinformatics and digital health. These include BioLizard, Cergentis, Enzyre, Epify, Fertiga, myNEO and OHMX.bio. Geographically, the exception was its investment in doc.ai, a digital health company based in the U.S. For Fund 2, Novalis will expand to other areas in Europe and make additional investments in the U.S.

About Novalis

Novalis provides seed funding and ongoing support to biotechnology and life sciences companies. Novalis incubates and advances its own ideas or supports existing innovative life science start-ups. The companys core competence lies in the interaction between bioinformatics, genomics, and digitalization in the life sciences industry. Novalis strongly believes in applying innovative information technology to advance the prevention, diagnosis, or treatment of a disease. For more information, please visit http://www.noval.is.

View source version on businesswire.com: https://www.businesswire.com/news/home/20201123005574/en/

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Novalis Biotech Announces First Closing of its Second Healthcare Fund - BioSpace

The report aims to offer a clear picture of the current scenario and future growth of the global Cancer Biomarkers Market market. The report provides scrupulous analysis of global market by thoroughly reviewing several factors of the market such as vital segments, regional market condition, market dynamics, investment suitability, and key players operating in the market. Besides, the report delivers sharp insights into present and forthcoming trends & developments in the global market.The report articulates the key opportunities and factors propelling the global Cancer Biomarkers Market market growth. Also, threats and limitations that have the possibility to hamper the market growth are outlined in the report. Further, Porters five forces analysis that explains the bargaining power of suppliers and consumers, competitive landscape, and development of substitutes in the market is also sketched in the report.

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Impact of COVID-19 on Cancer Biomarkers Market Industry:

The novel coronavirus pandemic has led to an inevitable recession and impacted the world economy in 2020. Three main factors of the global economy to have been affected are firms and financial markets, supply chains, and production. The report includes a complete, in-depth analysis of the Cancer Biomarkers Market market, featuring the COVID-19 impact, and future outlook of the industry. It divulges the political, economic, social, and technological scenario of the markets.

The report reveals various statistics such as predicted market size and forecast by analyzing the major factors and by assessing each segment of the global Cancer Biomarkers Market market. Regional market analysis of these segments is also provided in the report. The report segments the global market into four main regions including Asia-Pacific, Europe, North America, and LAMEA. Moreover, these regions are sub-divided to offer an exhaustive landscape of the Cancer Biomarkers Market market across key countries in respective regions. Furthermore, the report divulges some of the latest advances, trends, and upcoming opportunities in every region.

Furthermore, the report profiles top players active in the global Cancer Biomarkers Market market are Abbott Laboratories, F.Hoffmann-La Roche Ltd., QIAGEN, Thermo Fisher Scientific Inc., Affymetrix Inc., Illumina Inc., Agilent Technologies, Merck & Co. Inc., Hologic Inc., Sino Biological Inc., Becton, Dickinson and Company A comprehensive summary of top foremost players operating in the global market is delivered in the report to comprehend their position and footmark in the industry. The report highlights various data points such as short summary of the company, companys financial status and proceeds, chief company executives, key business strategies executed by company, initiatives undertaken & advanced developments by the company to thrust their position and grasp a significant position in the market.

The report also summarizes other important aspects including financial performance, product portfolio, SWOT analysis, and recent strategic moves and developments of the leading players.

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KEY MARKET SEGMENTS

The global Cancer Biomarkers Market market is segmented on the basis of the following:

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Penetration: Key instances of the Covid-19 impact on the Cancer Biomarkers Market - The Courier

Princess Margaret scientists have revealed how stem cells are able to generate new blood cells throughout our life by looking at vast, uncharted regions of our genetic material that hold important clues to subtle biological changes in these cells.

The finding, obtained from studying normal blood, can be used to enhance methods for stem cell transplantation, and may also shed light into processes that occur in cancer cells that allow them to survive chemotherapy and relapse into cancer growth many years after treatment.

Using state-of-the art sequencing technology to perform genome-wide profiling of the epigenetic landscape of human stem cells, the research revealed important information about how genes are regulated through the three-dimensional folding of chromatin.

Chromatin is composed of DNA and proteins, the latter which package DNA into compact structures, and is found in the nucleus of cells. Changes in chromatin structure are linked to DNA replication, repair and gene expression (turning genes on or off).

The research by Princess Margaret Cancer Centre Senior Scientists Drs. Mathieu Lupien and John Dick is published in Cell Stem Cell, Wednesday, November 25, 2020.

"We don't have a comprehensive view of what makes a stem cell function in a specific way or what makes it tick," says Dr. Dick, who is also a Professor in the Department of Molecular Genetics, University of Toronto.

"Stem cells are normally dormant but they need to occasionally become activated to keep the blood system going. Understanding this transition into activation is key to be able to harness the power of stem cells for therapy, but also to understand how malignant cells change this balance.

"Stem cells are powerful, potent and rare. But it's a knife's edge as to whether they get activated to replenish new blood cells on demand, or go rogue to divide rapidly and develop mutations, or lie dormant quietly, in a pristine state."

Understanding what turns that knife's edge into these various stem cell states has perplexed scientists for decades. Now, with this research, we have a better understanding of what defines a stem cell and makes it function in a particular way.

"We are exploring uncharted territory," says Dr. Mathieu Lupien, who is also an Associate Professor in the Department of Medical Biophysics, University of Toronto. "We had to look into the origami of the genome of cells to understand why some can self-renew throughout our life while others lose that ability. We had to look beyond what genetics alone can tell us."

In this research, scientists focused on the often overlooked noncoding regions of the genome: vast stretches of DNA that are free of genes (i.e. that do not code for proteins), but nonetheless harbour important regulatory elements that determine if genes are turned on or off.

Hidden amongst this noncoding DNA - which comprise about 98% of the genome - are crucial elements that not only control the activity of thousands of genes, but also play a role in many diseases.

The researchers examined two distinct human hematopoietic stem cells or immature cells that go through several steps in order to develop into different types of blood cells, such as white or red blood cells, or platelets.

They looked at long-term hematopoietic stem cells (HSCs) and short-term HSCs found in the bone marrow of humans. The researchers wanted to map out the cellular machinery involved in the "dormancy" state of long-term cells, with their continuous self-renewing ability, as compared to the more primed, activated and "ready-to-go" short-term cells which can transition quickly into various blood cells.

The researchers found differences in the three-dimensional chromatin structures between the two stem cell types, which is significant since the ways in which chromatin is arranged or folded and looped impacts how genes and other parts of our genome are expressed and regulated.

Using state-of-the-art 3D mapping techniques, the scientists were able to analyze and link the long-term stem cell types with the activity of the chromatin folding protein CTCF and its ability to regulate the expression of 300 genes to control long-term, self-renewal.

"Until now, we have not had a comprehensive view of what makes a stem cell function in a particular way," says Dr. Dick, adding that the 300 genes represent what scientists now think is the "essence" of a long-term stem cell.

He adds that long-term dormant cells are a "protection" against malignancy, because they can survive for long periods and evade treatment, potentially causing relapse many years later.

However, a short-term stem cell that is poised to become active, dividing and reproducing more quickly than a long-term one, can gather up many more mutations, and sometimes these can progress to blood cancers, he adds.

"This research gives us insight into aspects of how cancer starts and how some cancer cells can retain stem-cell like properties that allow them to survive long-term," says Dr. Dick.

He adds that a deeper understanding of stem cells can also help with stem cells transplants for the treatment of blood cancers in the future, by potentially stimulating and growing these cells ex vivo (out of the body) for improved transplantation.

See more here:
Mapping out the mystery of blood stem cells - Science Codex

QUIONES

Adriana Quiones remembers the exact moment she decided to switch her career path to public gardening, which ultimately led to her current position as executive director of Peace River Botanical & Sculpture Gardens.

I was in Ohio and eventually worked for a national nonprofit in the green industry, which is plants, but it represented the for-profit side of things landscapers, garden centers, greenhouse growers, nurseries, things like that.

As an educational program director there, she was organizing conferences and recruiting guest speakers.

I liked that job and loved who I worked with, Ms. Quiones said, but there was a day I was in my office after sending 2,000 emails, and I looked out my window because I was tired of looking at my screen, and the guys were out landscaping. And I thought, I really miss being in a garden. And at that point, I decided I really needed to get back to public gardening, which is why I went to college in the first place.

Adriana Quiones poses by Steel Palm, a sculpture by Boston artist Jacob Kulin. It literally is paradise here, in my opinion, she says. I hate the cold, which is my Puerto Rican blood. Everybody told me Id be too hot down here, but no. I wear sweaters. CREDIT: BOB MASSEY / FLORIDA WEEKLY

That college career was impressive, and didnt come until she was already working in an arboretum an unusual job choice for someone who hated flowers growing up.

I just fell in love with trees and woody plants, Ms. Quiones said. I loved the permanence of them. There was one particular tree there that I fell in love with. It was called Stewartia pseudocamellia. I always get that name in every interview I do. That tree was so beautiful. I thought, If I can do trees, this Ill like.

After distinguishing herself by graduating summa cum laude with a bachelors degree in landscape horticulture from Ohio State University, she received a full academic scholarship to enter the OSU masters degree program in plant molecular genetics. There, she studied the genetic pathways leading to flowering in Magnolia virginiana, where she discovered and named three genes.

My mom said, Of all my children, youre the last one Id expect to go into horticulture, Ms. Quiones said with a laugh.

The career that seemed to run through her family was art but she almost didnt have a family. In fact, she almost wasnt born.

My dad was born and raised in Puerto Rico, but he served in the Army during the Korean War, Ms. Quiones explained. He had something miraculous happen, where he was supposed to get on a boat twice, and they called him off the boat. On one of those ships, most of the people died.

Her father lived to attend art school on the G.I. Bill, choosing the rinky dink Columbus Art School in Columbus, Ohio, over New Yorks Pratt Institute because it was cheaper to live there.

He spoke no English when he came here, Ms. Quiones said. He had no family in Ohio, knew no one. He ended up working as a graphic artist for the Department of Defense for his career in Columbus. Then he met my mom during that time, married her and had three girls.

Ms. Quiones, as well as her two older sisters, attended art school, to which Ms. Quiones had gotten a scholarship. Her son is an architect, and her daughter graduated with a degree in animation and illustration before enlisting in the Marines to become a combat artist.

She was deployed three times, and drew pictures, Ms. Quiones said. She just got out of active duty (in October).

The news that her daughter was going into the military was a surprise to Ms. Quiones.

Were a family of artists we make art, not war, she joked, belying her obvious motherly pride. And going into the Marines, of all the branches?

As she did in school, Ms. Quiones continues to excel in her profession. For example, the American Public Gardens Association is the trade organization for that industry, serving more than 600 member institutions representing more than 9,000 garden professionals in 14 countries. Ms. Quiones sits on its national board of directors, chairs the IDEA committee, and serves on the scholarship and governance committees.

She intends to use her skills, influence and experience to raise the level of Peace River Botanical & Sculpture Gardens.

I believe this garden will become a national-caliber garden, she said. How long that will take, I dont know Id like to say sooner rather than later but thats what this garden is headed toward. That is the goal of everyone involved here, is to bring us to the point where we are a national attraction, not just a local, attraction.

We want to add more sculptures. The sculpture part of this garden is what makes it unique. Selby is on the water. Naples is on the water. So we cant just say were on the water. To have this collection of sculptures from all over the world, by artists who are known internationally, and to expand that part of it, thats going to bring this garden up to quite a higher level.

As for now, she views Peace River Botanical & Sculpture Gardens as a haven of sorts. During the course of the pandemic, people can feel isolated. She wants the gardens to be a place where people can come to volunteer, meet others with like minds and interests, make friends and not feel so alone.

Were developing our educational programs so we can reach out to teach people about things that interest them, Ms. Quiones said. I have a bonsai class coming up. We have a class on the sensory garden. Weve become a community resource; we can talk about the environment.

Thats the stuff that excites me.

See more here:
The blossoming career of Adriana Quiones - Florida Weekly

Most everyones holiday plans were modified this year, but members of the University community are still finding ways to express gratitude, visit virtually and help others this Thanksgiving.

Some folks have opted to celebrate Thanksgiving at Pitt. Thats the case with students Isaiah Spencer-Williams, Samuel Copeland and Jahari Mercer, who live in the same house and will cook their own Thanksgiving meal while also making time to video chat with their families.

We thought it would be best for us to remain here and get tested before we leave for winter break, said Spencer-Williams, a second year PhD student studying civil and environmental engineering in Pitts Swanson School of Engineering.

The three said they are taking the time to achieve a semblance of normalcy while strengthening bonds.

Its finding ways to be creative and creating special moments with family and friends while adjusting to the pandemic, said Mercer, a first-year Master of Business Administration candidate in Pitts Joseph M. Katz Graduate School of Business.

Were all trying to have a good time through all of this, and this would bring us closer together as friends, said Copeland, a junior civil engineering major in the Swanson School.

Others are taking the time to help their neighbors through the holiday season.Susan Fullerton, associate professor ofchemical and petroleum engineering, said her family will make baked goods for some neighbors who recently lost some loved ones.

We want to try and give them a little bit of joy on what will be a difficult day for them. It will be fun putting Mister Rogers message of being neighborly into action, said Fullerton.The show (Mister Rogers Neighborhood) was really big for usmy husband and I grew up watching it. My daughters are now really into the spinoff show, Daniel Tigers Neighborhood.

She said she wants her children to take opportunities to empathize with other people and try to help whenever they can. Mister Rogers said to look for the helpers. You will always find people who are helping.

Brittany Rodriguez, a bioengineering graduate student, works with PITT STRIVE, a program that eases the transitions of underrepresented minority students into doctoral engineering programs at Pitt.

Every year since high school, Rodriguez sends a Thanksgiving meal to families in need. I got to see firsthand people who werent able to get a meal for Thanksgiving and they didnt have enough money to put food on the table, she said. Seeing that broke my heart, so I wanted to do the best I could to give people at least one thing. Rodriguez says she encourages others to give during the holidays.

The Pitt Pantry offered another way to get involved with the special Wednesday distribution of Thanksgiving dinner kits to students who cant go home for Thanksgiving this year.

Here are a few other ways members of the Pitt community are celebrating Thanksgiving during these unprecedented times.

John V. Williams, member of the COVID-19 Medical Response Office, division director, Infectious Diseases; Henry L. Hillman Professor of Pediatrics and Microbiology & Molecular Genetics; director, Institute for Infection, Inflammation, and Immunity in Children (i4Kids): Usually, we have extended family with 20 or more people from both sides and possibly friends. This year, itll be only immediate family. We were going to have the grandparents eating six feet away, but given the increasing cases, we canceled. We would rather wait until its safe to have family Thanksgiving sometime next year.

Ann E. Cudd, provost and senior vice chancellor: I plan to start Thanksgiving Day with a pre-meal run in Schenley Park. My husband and I are looking forward to trying some new recipes from NYT Cooking that we've been curious about for a while. At dinner, it will be just the two of us eating togetherbut we plan to Zoom with family members coast to coast. I'm also looking forward to watching the Steelers, reading and looking at photos from last year's Florida family Thanksgiving. Wed hoped to do that again, but we'll wait now for a safer opportunity.

Everette James, interim dean of the Graduate School of Public Health, director of the Health Policy Institute, M. Allen Pond Professor of health policy and management and associate vice chancellor for health policy and planning: The James family will be celebrating Thanksgiving at home in Pittsburgh this year with our daughters. Our daughter Katie who plays college golf recovered from COVID-19 two weeks ago and travelled to Pittsburgh on a direct flight from Dallas after testing negative prior to departure. We will be joining grandparents via Zoom for a Thanksgiving old home movie sharing and holiday toasts. Happy thanksgiving all!

Beth Hoffman, research assistant, Center for Research on Media, Technology and Health: Every Thanksgiving my sister and I watch The West Wing and Friends Thanksgiving-themed episodes before dinner, and that tradition will continue this year.

Kenyon Bonner, vice provost and dean of students: This year, our family will be celebrating Thanksgiving Day with the members of our household only. We will deliver Thanksgiving dinner (contactless) to our college student who lives off campus and join other members of our family virtually. My wife and I will miss seeing everyone in person but rest easier knowing that everyone is safe.

Jamie Ducar, director of community engagement in the Office of Community and Governmental Relations (CGR): Thanksgiving this year will be small and festive. Now that my son is two, he can finally start to enjoy and understand family holiday traditions. Speaking of new traditions, my family set up a Zoom game night Thursday evening after dinner. Its been nice to connect more regularly and check in on one another.Additionally, CGR & Pitt Athletics worked together to support neighbor-led efforts to increase access to holiday meals in Homewood and Hazelwood. Im currently brainstorming how the Pitt community can celebrate the holiday spirit in new and different ways.

Read more:
Giving Thanks Around the Community | Pittwire | University of Pittsburgh - UPJ Athletics

Researchers from Mount Sinai and the National Center for Geriatrics and Gerontology in Japan have identified new molecular mechanisms driving late-onset Alzheimer's Disease (LOAD), as well as a promising therapeutic candidate for treatment, according to a study in the journal Neuron. LOAD is the most prevalent form of dementia among people over age 65, a progressive and irreversible brain disorder affecting more than 5.5 million people in the U.S., and the sixth leading cause of death.

"Our study advances the understanding of LOAD pathogenesis by revealing not only its global structures, but detailed circuits of complex molecular interactions and regulations in key brain regions affected by LOAD," said the lead author Bin Zhang, PhD, Professor of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai and Director of the Center for Transformative Disease Modeling. "The network models we created serve as a blueprint for identifying novel therapeutic targets that respond directly to the urgent need for new ways to prevent, treat, and delay the onset of LOAD."

Previous genetic and genome-wide association studies (GWAS) have identified some genetic mutations associated with LOAD, but the causal variants of the disease have remained uncharacterized. To explore the molecular mechanisms driving the pathogenesis of LOAD, the Mount Sinai-led team performed an integrative network biology analysis of a whole genome and RNA sequencing dataset from multiple cortical brain regions of hundreds of donors, both healthy and with LOAD. This work revealed thousands of molecular changes and uncovered numerous neuron-specific gene subnetworks dysregulated in LOAD.

From that investigation researchers predicted that ATP6V1A, a protein-coding gene, plays a major role in a critical signaling pathway in the brain, and that its deficit could be traced to LOAD. That linkage was evaluated using two methods: a CRISPR-based technique to manipulate ATP6V1A levels in donor-matched brain cells in vitro, and in RNAi-based knockdown in transgenic Drosophila models, meaning that genetic material is artificially introduced into fly models and specific genes are effectively silenced to study the effects. Indeed, the knockdown of ATP6V1A worsened LOAD-related neurodegeneration in both models.

Just as significantly, researchers predicted that a drug compound, NCH-51, could normalize the dysregulated genes in LOAD, including ATP6V1A, and demonstrated that NCH-51 dramatically improved the neuronal and neurodegenerative effects of the ATP6V1A deficit in both model systems. Specifically, the CRISPR-based experiment using human induced pluripotent stem cells (hiPSC) demonstrated that repression of ATP6V1A, particularly in combination with -amyloid -- a key neuropathological hallmark of AD -- dramatically impacted neuronal function. "The human-based system we created proved to be a promising way to model the mechanisms underlying risk and progression in diseases like LOAD where living tissues are not available," observed Kristen Brennand, PhD, Associate Professor, Genetics and Genomic Sciences, Mount Sinai, and co-author of the study.

The Drosophila experiments were also revealing, demonstrating that ATP6V1A deficit exacerbated both -amyloid-mediated toxicity and tau-mediated axon degeneration. "This finding suggests that ATP6V1A may have broad neuroprotective effects and serve as a potential therapeutic target for other tau-related neurodegenerative diseases," says Dr. Koichi M. Iijima, Head of the Department of Alzheimer's Disease Research at the National Center for Geriatrics and Gerontology in Japan, and senior author of the study.

As Dr. Zhang points out, the groundbreaking research by Mount Sinai and its Japanese partner could have significance beyond just LOAD. "We've created a framework for advanced modeling of complex human diseases in general," he explains, "and that could well lead to the discovery of molecular mechanisms and the identification of novel targets that are able to deliver transformative new therapeutics."

See original here:
Potential new therapies for Alzheimer's disease are revealed through network modeling of its complex molecular interactions - Science Codex

Baylor College of Medicine and other institutions joined theHuman Heredity and Health in Africa (H3Africa) Consortium in a collaborative global research project supported by the National Institutes of Health to sequence genomes from regions and countries across Africa. The research paves the way for more broadly representative and relevant studies ranging from basic through clinical genetics.

TheHuman Genome Sequencing Centerat Baylor College of Medicine worked with the H3Africa consortium and local African governments to acquire consented samples from 13 countries across the continent and generate high-coverage whole genome sequence data on 314 individuals representing 50 ethnolinguistic groups. This allowed the researchers to examine rare genetic variants in an accurate and quantifiable way, in addition to the common variants that have been the focus of most of the previous genetic studies in Africans.

Migrations

We found an impressive breadth of genomic diversity among these genomes, and each ethnolinguistic group had unique genetic variants, said senior author, Dr. Neil Hanchard, assistant professor of molecular and human genetics and the USDA/ARS Childrens Nutrition Research Center at Baylor College of Medicine and senior author on the study. There was a great deal of variation among people in the same region of Africa, and even among those from the same country. This reflects the deep history and rich genomic diversity across Africa, from which we can learn much about population history, environmental adaptation and susceptibility to diseases.

The researchers showed more than 3 million novel variants in the genomes sequenced, and were able to use the data to examine historic patterns and pinpoint migration events that were previously unknown.

For the first time, our data showed evidence of movement that took place 50 to 70 generations ago from East Africa to a region in central Nigeria. This movement is reflected in the genomes of a Nigerian ethnolinguistic group and is distinct from previous reports of gene flow between East and West Africa, said Dr. Adebowale Adeyemo, deputy director of the Center for Research on Genomics and Global Health at the National Human Genome Research Institute, and a senior author on the study. This data gives us a more complete picture of the genetic history of Africa.

Forces of natural selection

The researchers found more than 100 areas of the genome with evidence of being under natural selection. A sizable proportion of these regions were associated with genes related to immunity.

When you consider which forces have shaped African genetic diversity, you might think of malaria and sleeping sickness, Hanchard said. Our study suggests that viral infections could also have influenced genomic differences between people, via genes that affect individuals disease susceptibility.

There were also noticeable variations in selection signals between different parts of the continent.

Our findings suggest that adaptation to local environments, diets or pathogens might have accompanied the migration of populations to new geographic regions, said Dr. Dhriti Sengupta, one of the lead analysts from SBIMB, University of Witwatersrand.

The researchers hope their work will lead to wider recognition of the extent of undocumented genomic variation across the African continent, and of the need for continued studies of the many diverse populations in Africa.

Adding genomic data from diverse populations is essential to ensure that all global populations can benefit from the advances in health that precision medicine offers, saidDr. Zan Lombard, associate professor at the Division of Human Genetics of the University of the Witwatersrand, South Africa, and a senior author on the study.

Are you interested in reading all the details of this work? Find them in the journal Nature.

Dr. Richard Gibbs, Donna Muzny and Ginger Metcalf from the Human Genome Sequencing Center at Baylor contributed to this work. Find the complete list of all the contributors and their affiliations, as well as the financial support for this study in thepublication.

By Molly Chiu

View original post here:
African genomes reveal biological and migration history - Baylor College of Medicine News

LA JOLLA, Calif., Nov. 24, 2020 (GLOBE NEWSWIRE) -- MediciNova, Inc., a biopharmaceutical company traded on the NASDAQ Global Market (NASDAQ:MNOV) and the JASDAQ Market of the Tokyo Stock Exchange (Code Number: 4875), today announced that Good Manufacturing Practice (GMP)-based Master Virus Seed Stock (MVSS) production of its novel intranasal SARS-CoV-2 vaccine for COVID-19, using BC-PIV technology, has been initiated at Millipore Sigma BioReliance Services, a group company of Merck KGaA, Darmstadt, Germany.

Yuichi Iwaki, M.D., Ph.D., President and Chief Executive Officer of MediciNova, Inc. commented, We are pleased to begin production of MVSS, a key step in the production of vaccines, at Millipore Sigma BioReliance Services. We look forward to producing an effective intranasal COVID-19 vaccine and reporting additional development progress in the near future.

About Master Virus Seed Stock (MVSS)

MVSS is a seed virus necessary to produce BC-PIV/S. By infecting MVSS to the packaging cells, BC-PIV/S is produced, which is then recovered and purified to produce the BC-PIV SARS-CoV-2 vaccine for clinical studies.

About the BC-PIV SARS-CoV-2 Vaccine for COVID-19

BC-PIV, an innovative non-transmissible viral vector co-developed by BioComo and Mie University, is derived from the recombinant human parainfluenza virus type 2 (hPIV2). It is highly efficient in its ability to transfer multiple foreign proteins to recipients and has a strong safety profile as no secondary infectious virus is produced. BC-PIV is designed to display not only the gene but also the foreign protein itself on the surface and inside of the viral membrane. Therefore, it can carry the large membrane proteins of viruses and signal transduction receptors/ligand proteins on the viral surface. BC-PIV is able to carry the proteins that require a proper three-dimensional structure or multimeric structure while maintaining the structure. BC-PIV elicits good immunogenicity against antigen proteins without adjuvants. The BC-PIV SARS-CoV-2 vaccine prototype has been developed to include the specific SARS-CoV-2 antigen protein in order to express maximum antigenicity. The BC-PIV SARS-COV-2 vaccine can be developed as an intranasal vaccine in addition to an intramuscular injection because of its high affinity to nasal and upper respiratory tract mucosa, which is the same route of the natural infection of SARS-CoV-2. An intranasal vaccine is expected to induce local mucosal immunity. To date, BioComo has succeeded in producing a recombinant Ebola virus vaccine (https://www.nature.com/articles/s41598-019-49579-y) and a Respiratory Syncytial virus prefusion F vaccine (unpublished data) using this BC-PIV platform technology.

About BioComo

BioComo, a biotech company founded at Mie Prefecture Japan in May 2008, is developing cutting-edge technology platforms for creating the novel and predominant vaccine carriers and adjuvants to enhance immunity in collaboration with the Microbiology and Molecular Genetics Department of Mie University. They have already succeeded in the development of a highly efficacious and state-of-the art vaccine carrier and novel adjuvant candidates. Their technology will be applied to the production of the next generation vaccines for the prevention of infections such as RS virus, Ebola virus, Influenza virus, and SARS-CoV-2. It will also enable faster and more cost-effective production of those vaccines. BC-PIV is the core platform technology which carries the corporate namesake, BioComo, and the leading vaccine carrier that is derived from the recombinant human parainfluenza virus 2 (hPIV2) vectors. BioComo is dedicated to inventing new vaccines for both global infection threats as well as malignant tumors.

About MediciNovaMediciNova, Inc. is a publicly traded biopharmaceutical company founded upon acquiring and developing novel, small-molecule therapeutics for the treatment of diseases with unmet medical needs with a primary commercial focus on the U.S. market. MediciNova's current strategy is to focus on BC-PIV SARS-COV-2 vaccine for COVID-19, MN-166 (ibudilast) for neurological disorders such as progressive multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and substance dependence (e.g., alcohol use disorder, methamphetamine dependence, opioid dependence) and glioblastoma, as well as prevention of acute respiratory distress syndrome (ARDS) caused by COVID-19, and MN-001 (tipelukast) for fibrotic diseases such as nonalcoholic steatohepatitis (NASH) and idiopathic pulmonary fibrosis (IPF). MediciNovas pipeline also includes MN-221 (bedoradrine) for the treatment of acute exacerbations of asthma and MN-029 (denibulin) for solid tumor cancers. MediciNova is engaged in strategic partnering and other potential funding discussions to support further development of its programs. For more information on MediciNova, Inc., please visit http://www.medicinova.com.

Statements in this press release that are not historical in nature constitute forward-looking statements within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, without limitation, statements regarding the future development and efficacy of BC-PIV SARS-COV-2 vaccine, MN-166, MN-001, MN-221, and MN-029. These forward-looking statements may be preceded by, followed by or otherwise include the words "believes," "expects," "anticipates," "intends," "estimates," "projects," "can," "could," "may," "will," "would," considering, planning or similar expressions. These forward-looking statements involve a number of risks and uncertainties that may cause actual results or events to differ materially from those expressed or implied by such forward-looking statements. Factors that may cause actual results or events to differ materially from those expressed or implied by these forward-looking statements include, but are not limited to, risks of obtaining future partner or grant funding for development of BC-PIV SARS-COV-2 vaccine, MN-166, MN-001, MN-221, and MN-029 and risks of raising sufficient capital when needed to fund MediciNova's operations and contribution to clinical development, risks and uncertainties inherent in clinical trials, including the potential cost, expected timing and risks associated with clinical trials designed to meet FDA guidance and the viability of further development considering these factors, product development and commercialization risks, the uncertainty of whether the results of clinical trials will be predictive of results in later stages of product development, the risk of delays or failure to obtain or maintain regulatory approval, risks associated with the reliance on third parties to sponsor and fund clinical trials, risks regarding intellectual property rights in product candidates and the ability to defend and enforce such intellectual property rights, the risk of failure of the third parties upon whom MediciNova relies to conduct its clinical trials and manufacture its product candidates to perform as expected, the risk of increased cost and delays due to delays in the commencement, enrollment, completion or analysis of clinical trials or significant issues regarding the adequacy of clinical trial designs or the execution of clinical trials, and the timing of expected filings with the regulatory authorities, MediciNova's collaborations with third parties, the availability of funds to complete product development plans and MediciNova's ability to obtain third party funding for programs and raise sufficient capital when needed, and the other risks and uncertainties described in MediciNova's filings with the Securities and Exchange Commission, including its annual report on Form 10-K for the year ended December 31, 2019 and its subsequent periodic reports on Form 10-Q and current reports on Form 8-K. Undue reliance should not be placed on these forward-looking statements, which speak only as of the date hereof. MediciNova disclaims any intent or obligation to revise or update these forward-looking statements.

Read more here:
MediciNova Announces Initiation of Master Virus Seed Stock Production for its Intranasal COVID-19 Vaccine using BC-PIV Vector Technology -...

US rare disease-focused biotech BioMarin has entered a preclinical collaboration with Toronto-based artificial intelligence (AI) company Deep Genomics to discover and develop oligonucleotide drug candidates for four undisclosed rare diseases with high unmet need.

According to the terms of the agreement, the partners will leverage Deep Genomics AI drug discovery platform, the AI Workbench, to identify and validate target mechanisms and lead candidates, while BioMarin will be responsible for pre-clinical and clinical development.

Once candidates are found, BioMarin will have the exclusive option to Deep Genomics rights to the programmes. In return, Deep Genomics will receive upfront and development milestone payments from BioMarin. Although BioMarins policy is not to disclose financial information, Deep Genomics CEO and founder Brendan Frey notes the upfront and near-term payments are comparable and similar to recent deals coming out of other AI companies, like insitro, Recursion and Atomwise.

In September, Recursion signed an $80m deal with Bayer for AI-guided small molecule drug discovery collaboration. insitro is set to receive a $50m upfront payment and $20m in near-term payments from Bristol Myers Squibb for a partnership focused on discovering drugs for neurodegenerative diseases.

Founded in 2015, Deep Genomics work centres around the capabilities of its genetic disease-focused AI Workbench, which leverages deep learning, automation and vast amounts of in vitro and in vivo data. Frey explains the AI Workbench is the backbone of everything we do from identifying drug targets and designing drugs, to ensuring that the correct experimental materials and protocols are used.

The company carried out a proof of concept in 2019 in Wilsons disease, a recessive genetic disorder linked with the ATP7B gene that causes liver disease and neurological abnormalities, and proved the platform could identify a gene target and design a therapeutic candidate to correct the mutation. Frey explains: That was a breakthrough for AI in biotech, and this program is on the way to the clinic.

However, following this, Deep Genomics moved to expand and refine the capabilities of the Workbench. This second-generation version enables Deep Genomics to find genetic determinants of disease, to understand disease pathology, and to identify a lead therapeutic candidate to resolve that disruption by enhancing protein expression, according to Frey.

He adds: For novel target mechanisms identified by our AI Workbench, 50% of them result in lead drug candidates, and we can achieve that within 12 months. This speed and efficacy, Frey argues, is unprecedented in the AI discovery field.

Deep Genomics AI Workbench 2.0 will be leveraged in its collaboration with BioMarin to discover oligonucleotide therapies. This type of therapy is a particular focus of Deep Genomics platform because it can successfully predict alterations in molecular phenotypes, such as transcription, splicing, translation and protein binding. Deep Genomics therapeutic for Wilsons disease is an oligonucleotide and is progressing into pre-clinical trials.

Frey explains that collaborating with BioMarin is an important proof for Deep Genomics and its platform. BioMarin is a [rare disease] industry leader and has its pick of AI therapeutics companies to partner with, he says. They chose Deep Genomics because we are unique in having technology that gives us line of sight from genetics of disease to novel therapeutic targets and drug candidates.

This deal with BioMarin positions Deep Genomics to be the go-to company for advancing novel targets and oligonucleotide therapies.

BioMarin chief scientific strategy officer and senior vice-president Lon Cardon noted in a statement: We believe the combination of Deep Genomics experience in using artificial intelligence to creatively modulate targets coupled with our proven track record in developing transformational medicines for patients with rare diseases will speed BioMarins trajectory into new biological frontiers.

Frey is hopeful that Deep Genomics will have identified a lead candidate for two of the four targeted disease indications within one year.

Deep Genomics is planning to use the undisclosed upfront and near-term upfront payments from BioMarin to also extend our cash runway as we look to build our internal pipeline while also seeking other partnerships to take advantage of the broad applicability of the AI Workbench, according to Frey.

He explains that partnering will be central to Deep Genomics corporate strategy as the platform is developing programs more rapidly than any small company would be able to advance independently. In the first quarter of 2021, Deep Genomics is expecting to sign one more pharma partnership.

Generally, Deep Genomics strategy is to partner with companies interested in our current programs or a target they have been exploring, says Frey. In addition to exploring Wilsons disease, Deep Genomics is advancing programmes in neurodegenerative and neurodevelopment disorders, such as early-onset epilepsy.

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BioMarin and Deep Genomics team up on AI rare disease drug discovery - pharmaceutical-technology.com

A recent report on the Opthalmic Drugs market published by Fact.MR elaborates on factors responsible for its growth. The global Opthalmic Drugs market is anticipated to gain momentum in the coming years and exhibit a CAGR ofxx%. The report emphasizes growth parameters such as drivers, restraints, upcoming challenges, and future opportunities. It also lists the names of players functioning in the Opthalmic Drugs market and the strategies adopted by them to stay put in the market competition. The entry of new players with their motive is also discussed in the report.

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Tissue Ablation Market Research Report: Know Market Dynamics, Opportunities and Risks 2026 - The Market Feed

When he departs the White House on January 20, Donald Trump will leave this region with

a toxic legacy. First and foremost, his ongoing campaign to delegitimise the Palestinian people and encourage Israel to continue colonising their homeland has had disastrous consequences for both Palestine and countries further afield.

Trump defied decades old international policy by recognising occupied East Jerusalem as part of Israel's capital although its status is meant to be determined in negotiations between Palestine and Israel. Trump cancelled the US contribution to UNRWA, the UN agency providing for five million Palestinian refugees. This has deprived UNRWA of $665 million over two years and forced the agency to cut expenditures, services and staff jobs. For decades, the US donation had been one-third of UNRWA's budget. Trump has also cut off all funding for USAID projects in the Israeli-occupied Gaza Strip, West Bank, East Jerusalem, where the St John's Opthalmic and Makassad hospitals in East Jerusalem were defunded.

Trump closed the Palestinian diplomatic mission in Washington, launched his "Deal of the Century" peace plan which promised the Palestinians economic incentives to agree to accept autonomy in isolated islets of territory in Gaza, the West Bank, a capital on the edge of East Jerusalem and Israel's annexation of 30 per cent of the West Bank, including the Jordan Valley. Israel would remain in control of Palestinian air, land and sea. This plan rejected by the Palestinians, the Arabs, and the international community would have put paid to Palestinian hopes for an end to the occupation and statehood. Trump has consigned the Palestinian people to either endless occupation or perpetual exile.

Trump followed up these "gifts" to Israeli Prime Minister Binyamin Netanyahu and his right-wing government with others. In March 2019, he recognised as part of Israel, the occupied Syrian Golan Heights. In November of that year, his Secretary of State Mike Pompeo, a radical evangelical Christian, declared that Israeli "settlements" in occupied territory are not "inconsistent with international law", although occupiers are prohibited by international law from colonising and annexing conquered territories, a dikta accepted by the majority of countries. Pompeo's statement amounted to a reversal of the Obama's administration policy on "settlements" and of earlier administrations which regarded them, a least, as "obstacles" to a peace deal. Last week, Pompeo took a further provocative step by not only visiting an Israeli colony near Ramallah in the West Bank but also going to a colony in the Syrian Golan. Pompeo subsequently declared products from colonies could be labelled "Made in Israel", rather than in the West Bank or Golan colonies.

Pompeo piled on the administration's anti-Palestinian policies by declaring that Washington would regard as "anti-Semitic", the Palestinian-led Boycott, Divest, and Sanction (BDS) movement, designed to put pressure on Israel to end its occupation and reach a just deal with the Palestinians. He labelled BDS a "cancer". He said he would identify and sanction organisations that adopt "politically motivated actions intended to penalise or limit commercial relations with Israel". This policy would put an end to peaceful Palestinian, Arab and international resistance to Israel's occupation regime even though resistance both violent and peaceful is legal under international law.

As it nears the end of its term in office, the Trump administration has also ruled that US citizens born in Jerusalem can put "born in Israel" on their passports and that Jonathan Pollard, convicted of spying on the US navy for Israel, could leave the US to live in Israel although he had been banned from doing just this.

Trump also gifted Netanyahu with the withdrawal of the US from the 2015 six-nation agreement lifting sanctions on Iran in exchange for reducing its nuclear programme by 90 per cent. This involved violating the terms of a deal which has the force of an international treaty. Trump also reimposed sanctions which had been lifted and imposed fresh primary and secondary sanctions in order to prevent governments, businesses and individuals from dealing with Iran. This punitive policy, adopted during the global COVID pandemic, has impoverished millions of Iranians and Syrians, whose government is allied to Iran, and Lebanese, whose Hizbollah movement is tied to Iran. Why did Trump oblige Netanyahu? Because of the opposition to Israel of Iran, Syria, and Hizbollah.

Nevertheless, pulling out of the nuclear deal has not been enough for Netanyahu who has pressed the Trump administration to take military action against Iran. Trump did this by assassinating Iranian Quds Force commander Qassem Suleimani in Baghdad in January and by threatening further strikes if Iran retaliated. Tehran did not oblige and patiently awaits the end of Trump's reign.

The murder of Suleimani and Iraqi Abu Mahdi Al Muhandis, deputy head of Iraq's Popular Mobilisation Forces, which consists largely of pro-Iranian militias, prompted a vote in the Iraqi parliament demanding the total withdrawal of US and other foreign forces from that country. The Trump administration refused at first but is now planning to pull out 500 of the remaining 3,000 US troops deployed in Iraq. This is a half measure which will please neither the Pentagon nor the Iraqi people. They seek an end to the current Iran-friendly Shia sectarian regime and want both the US and Iran to stop intervening in their affairs.

The strike on Suleimani combined with anti-government protests led to the fall of Prime Minister Adel Abdul Mahdi and the formation of a new cabinet by Mustafa Al Kadhimi who has struggled to contain demonstrations and restrain pro-Iranian militias from mounting rocket attacks on military bases housing US forces. Determined to deny Trump a pretext to attack Iran itself, Tehran displayed its influence in Iraq by ordering the militias to suspend their attacks.

Trump's exit from the White House on January 20 will be welcomed by a majority of people in this region, but his destructive policies will be hard to reverse and will continue to inflict damage and suffering.

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Trump will leave this region with toxic legacy when departing White House - Jordan Times