header logo image


Page 250«..1020..249250251252..260270..»

5 Items You Should Always Have in Your Freezer, According To a Longevity Expert – Well+Good

December 16th, 2020 9:56 pm

The Blue Zoneswhich includes places like Ikaria, Greece and Okinawa, Japanare home to some of the worlds oldest and healthiest people. While a lot of factors play into how often theyre celebrating folks 100th birthdayslike having a larger purpose, natural movement, and stress managementthe food they put on their plate is a biggie.

You might think a typical Blue Zones-approved grocery list is loaded with hard-to-find exotic foods, but Dan Buettner, longevity expert and author of The Blue Zones Kitchen, has made it clear that theres only simple, wholesome, and nutritious options you can find at any store. Better yet, you dont even need to load your refrigerator with fresh fruit and veggies to eat like those living in centenarian hotspots. You can utilize your freezer to reap the same benefitsand save some money in the process.

The next time you schedule your grocery pick-up, make sure to bring these freezer foods for longevity home with you.

While fresh fruit can go bad in a matter of days, frozen fruit can last forever. The Blue Zones recommends stocking up on frozen fruit and adding it to smoothies, yogurt, and oatmealreally, whatever you want. In addition to fiber, these gems contain phytonutrients, which play a key role in gut and immune health, the site reads.

Stock up on:Berries, pineapple, mangoes, peaches, and other fruits you love

Its no surprise frozen veggies are on this list. Because theyre frozen at the peak of freshness, Blue Zones says theyll not only last a long time, but also provide the same nutritional benefits as the fresh kind. Plus, you can make frozen veggies taste just as great with the right cooking method. One of the easiest ways to prepare frozen veggies of any kind is to roast them in the oven with a drizzle of olive oil, garlic, and herbs.

Stock up on: Spinach, broccoli, cauliflower, riced cauliflower, butternut squash, asparagus, green beans, and any other veggies you love

Yep, bread is a freezer staple, too. Blue Zones recommends baking up a loaf of gut-friendly sourdough bread. Or, simply grab a loaf of 100 percent whole grain bread from the grocery store. Whenever youre ready for a new loaf, let it thaw in the fridge. Then enjoy some avocado toast or a veggie-packed sandwich.

Stock up on: Sourdough bread or 100 percent whole grain bread

The Blue Zones recommends storing nuts in your freezer for later use, too. In fact, nuts last longer in the freezer or refrigerator than they do in the pantry: The biggest reason to store dry goods in the refrigerator is to prevent the oils in nuts from turning rancid, says Emily Brekke, executive chef at Mint Kitchen. Eat two handfuls of nuts every day, which experts say can help decrease your risk of heart attack, stroke, cancer, and other health issues.

Stock up on: Walnuts, almonds, peanuts, Brazil nuts, and cashews

Buettner is a big fan of 100 percent whole grains, which store easily in your freezer after theyre cooked. Make preparing meals a breeze by preparing single-serve options of your favorite whole grains (he loves fiber-packed steel cut oats and brown rice), then freeze them until youre ready to use them. Instead of making a new batch of rice for every meal, you can warm up a pre-made batch in minutes.

Stock up on: Steel cut oats, brown rice, quinoa, farro, millet, and barley

For more healthy recipes and cooking ideas from our community, join Well+Goods Cook With Us Facebook group.

See more here:
5 Items You Should Always Have in Your Freezer, According To a Longevity Expert - Well+Good

Read More...

The American Academy of Anti-Aging Medicine Concludes the 28th Annual World Congress – GlobeNewswire

December 16th, 2020 9:56 pm

Boca Raton, Dec. 15, 2020 (GLOBE NEWSWIRE) -- The American Academy of Anti-Aging Medicine Concludes the 28th Annual World Congress

The 28th Annual World Congress | The Science of Longevity: Exploring the Limits of the Human Lifespan concluded on Sunday, December 13th. Delivered entirely online for the first since its inception, the highly anticipated event provided clinicians from around the world with direct access to over 30 renowned clinical educators, 5 in-depth clinical tracks, 30 advanced educational sessions, 8 product theater presentations, 40 featured industry sponsors, and moreall from the safety and comfort of their homes. Centered on the latest knowledge in longevity medicine, the conference delivered actionable, and clinically transformative solutions for clinicians to improve patient health spans.

Prior to the official start of the Congress, the Academy delivered two pre-conference events: the Pain & Cannabinoid Medicine Update and the Lab Fundamentals Workshop. Led by industry leading experts such as Drs. Wade Cooper, DO of the University of Michigan, Joseph Maroon, MD of the University of Pittsburgh, and more, these pre-conference workshops delivered in-depth expertise on valuable tools that participants could integrate immediately into practice.

The conference officially commenced on December 12th, with opening remarks delivered by A4M Educational Director, Dr. Andrew Heyman, MD, MHSA on the current state of healthcare and the future trajectory of longevity-based medicine. General sessions continued with presentations on topics such as fasting, hormones and immunocompetence, and the Wahls protocols from world-renowned clinicians Drs. Valter Longo, PhD, Thierry Hertoghe, MD, and Terry Wahls, MD respectively. The remainder of the day was divided into three separate educational tracks: regenerative therapies, the aging brain, and a non-cme track centered on cutting edge therapeutic options.

Day two of the conference began with a wide array of general sessions topics from industry experts including a presentation on the evolutionary gender differences role in longevity from Dr. Felice Gersh, the latest bio-hacking tools from Dave Asprey, and more. The conference continued with three subsequent tracks: the Longevity Toolbox, Immunocompetency and Aging, and the New Key to Vascular Health.

Additionally, 40 companies participated through the events Company Spotlight pagean interactive page that allowed attendees to browse through the latest tools, resources, and services at their convenience.

On the success of the conference, A4Ms educational directors remarked:

What an amazing weekend of the latest and cutting edge science in longevity medicine and prolonging human Health Span. We had world class clinicians and scientists from major academia and private sector teaching our attendees from around the globe the latest science and tools to expand our Health Span. So honored to be part of the academic programming committee where A4M has and continues to be the global leader in functional and longevity medicine education. - Sahar Swidan, PharmD, BCPS, ABAAHP, FAARFM, FACA | Director of Professional Programming, A4M

"The A4M Congress on Longevity Medicine was a great success! World class speakers. Incredible cutting edge content. And a huge online audience. I am so proud to be a part of this leading education organization. It is without peer as a global leader in Anti Aging and Regenerative Medicine. We will continue to maintain our high standards of academic excellence in 2021 and I look forward to all the new wonderful programs in the coming year. - Andrew Heyman, MD, MHSA | Director of Academic Affairs, A4M

Delivered during a undeniably transformative, challenging, and revealing year in modern medicine, the 28th edition of the Annual Anti-Aging World Congress delivered timely clinical pearls for practitioners seeking to improve the quality of patient health spans, and ultimately build a new and more resilient standard of healthcare.

The rest is here:
The American Academy of Anti-Aging Medicine Concludes the 28th Annual World Congress - GlobeNewswire

Read More...

Goshen mayor to receive $5,000 bonus in 2021 | News – Goshen News

December 16th, 2020 9:56 pm

GOSHEN Goshens mayor will be getting a pay increase heading into the new year following action by the Goshen City Council on Tuesday evening.

At the meeting, council members approved an ordinance establishing the 2021 compensation for elected city officials, though not before first approving an amendment to the ordinance calling for an increase in the mayors salary in the form of an annual $5,000 longevity bonus.The mayor will receive a bi-weekly salary in 2021 of $3,665, plus the new $5,000 longevity bonus

INCREASE, WITH CONDITIONS

Council president Brett Weddell, R-at Large, was responsible for putting forward the amendment calling for the mayoral salary bump, which as approved reads as follows:

Commencing at the beginning of the mayors fifth year in office, the mayor shall receive a longevity increase in pay in the amount of $5,000 during each year the mayor serves as mayor. The longevity increase in pay shall be included in the mayors regular bi-weekly paycheck. This increase in pay shall not be considered as part of the compensation of the mayor when considering increases or decreases in the mayors pay.

So, the base salary is the same, Weddell explained, noting that for a new mayor to be eligible to receive the annual longevity bonus, they would need to be re-elected to another four-year term, and thus begin their fifth year in the position.

Ive been proposing, I think for three or four years at least, trying to increase the mayors salary a little bit. Before my time, councilman Everett Thomas tried unsuccessfully. I know there has been some pushback on this. I was hoping, in discussion with our city attorney, that this might be a little more palatable for some people, so that way an incoming new mayor isnt getting the increase right away, and this is showing a little bit of an appreciation for the hard work that a mayor is doing. So, thats the idea behind it.

Given that Stutsman is currently finishing out his fifth year in office, having been re-elected to his second four-year term in 2019, it was explained that he will immediately be eligible to receive the annual $5,000 longevity bonus.

PAY BUMP NEEDED?

Council member Julia King, D-at Large, upon hearing of the proposed amendment, said she did not feel such an increase is warranted, noting primarily that the mayors current pay scale is in line with the mayors of many similarly sized cities in the state.

If you look at the size of the city, the number of employees, the area median income, the mayoral pay in similar cities, kind of the educational requirements, coupled with state statue guidance... To me, it doesnt make sense, because were very much in alignment with all of those things, King said of the proposed pay increase. Goshen is above average, in my research.

She also noted that during previous discussions about such an increase, the council had agreed to hold off on such a change until a full survey of all city employee salaries had been conducted.

My recollection was, the last time we talked about this, we agreed that there was going to be an attempt to do a complete salary review of all employees before we brought this back again, King said. And I understand why it didnt happen this year. But, do I misremember that? That was my recollection. Because Im open to something like that once I know, kind of up and down the board, everyone is taken care of.

In response, Weddell said he would still be open to moving forward with such a salary review for the citys employees, though he felt that when it came to the mayors salary, an increase was warranted and should be pursued immediately.

Im not going to compare us to other communities. I look, and I know, what job the mayor of our city does. I know the hours that he works. I know how he puts personal responsibilities and family aside for this job, and theres no doubt in my mind that its underpaid, plain and simple, Weddell said. I dont really care to compare it to other communities. I dont know what their mayors do. ... I know whats going on in our community, and if I compare the job that our mayor is doing, what hes in charge of, and compare it to executives in other businesses education, manufacturing and whatnot I think that this is small potatoes so to speak.

INCENTIVE TO EXCEL

Council member Megan Eichorn, D-District 4, offered a similar sentiment in voicing her support for the increase.

I think what I like about this amendment is that, in most jobs, people expect, or have an expectation of a wage scale. So, everyone within the city has this wage scale that they know that when they start here, and they get to 10 years down the road, theyre going to be making this amount of money, and that theres an increase. For the mayors position, there isnt that option, Eichorn said. So, I do think that this, having a base pay, which a new mayor would come in at, is a fair piece. And then putting in five years of work, you get this longevity increase, I think its absolutely consistent with how other industries work with regard to knowing that if youre there for a certain amount of time, youre going to be making more money.

And it also, I think, incentivizes mayors who are doing a good job to continuing wanting to stay, she added. Given the amount of hours and time that the job requires, whether its personal choice to put that amount in, or the requirement of the job, or the situation that were in, I know at least our mayor works far more hours than the average person. So, I think that doing something like this is very reasonable.

In the end, a majority of the councils members agreed, and a motion to approve the ordinance amendment adding the annual $5,000 longevity increase to the mayors salary was passed in a vote of 5-2 in favor.

Voting for the amendment were council members Weddell; Eichorn; Jim McKee, R-District 1; Doug Nisley, R-District 2; and Matt Schrock, R-District 3. Voting against the amendment were council members King and Gilberto Perez Jr., D-District 5.

With the amendment approved, the council then voted unanimously on both first and second readings to approve the ordinance establishing the 2021 compensation for elected city officials as amended.

This was a surprise to me tonight, and I really appreciate the councils support and thoughtfulness of how hard Im working, Stutsman said of the pay bump prior to Tuesdays vote. I do appreciate that, and I appreciate working with each of you. So, thank you.

ELECTED OFFICIALS

As approved Tuesday, the clerk-treasurer will receive a bi-weekly salary of $2,793; the city judge will receive a bi-weekly salary of $2,007; and the seven city council members will receive bi-weekly salaries of $584.

The ordinance also notes that the mayor, clerk-treasurer and judge must enroll in the citys group health insurance plan, where the city will pay 80% of the total cost, or $347.09, and the mayor, clerk-treasurer and judge pay 20% of the cost, or $86.77, toward the cost of the weekly health insurance premium.

The judge and council members are not eligible to enroll in the citys group health insurance plan, as they are considered to be employees working 1,300 hours or less per year, and thus do not qualify for coverage.

We are making critical coverage of the coronavirus available for free. Please consider subscribing so we can continue to bring you the latest news and information on this developing story.

See the original post here:
Goshen mayor to receive $5,000 bonus in 2021 | News - Goshen News

Read More...

New study aims to increase longevity of bee hives – The Bay’s News First – SunLive

December 16th, 2020 9:56 pm

Posted: 8:38am Tuesday 15 Dec, 2020

File Image.

New research backed by the Ministry for Primary Industries could help bumblebee hives to live longer and be more efficient.

The new project is researching ways to protect the long-term sustainability of New Zealand horticulture, including how to enhance the performance of bumblebee hives using pheromones.

MPI is contributing $160,000 towards the $400,000 project through its Sustainable Food & Fibre Futures fund.

Dr Gunjan Gera of Gourmet Waiuku Limited is leading the project, supported by consultant Dr Jo Stephens.

Dr Gera says bumblebees are often used for pollination in berryfruit crops, glasshouses, and other covered crop areas as the bees tend to travel only about 200 metres from their hives and dont mind enclosed spaces, whereas honeybees prefer to fly to flowers further afield.

In the field, the queen bumblebee of a commercial hive lives for approximately 8-10 weeks and the hive winds down once the queen dies.

With fewer worker bees, the hives can appear less active when compared to honeybees and there can be variation in vigour and productiveness.

Our project will study various factors and compounds in conjugation with the bumblebee queens to see if we can extend the life of a hive to at least 12-18 weeks. If this works, we have a way of complementing nature, using a pheromone substitute.

The technology is in its infancy overseas and commercial companies using it havent yet released much information, says Dr Jo Stephens.

Were hoping to lead the way in NZ, but it will involve a good deal of trial and error given the limited progress globally in this area.

Dr Stephens explains that bumblebees were introduced to New Zealand from the United Kingdom by the early pioneers, so there is limited genetic diversity. Although commercial breeders incorporate new genetic diversity from the wild occasionally, the gene pool is limited.

Another important part of the research will be screening bumblebees for diseases, including those associated with inbreeding.

Well be looking at the levels of inbreeding in New Zealand populations to see if this is a major concern, and whether we need to consider the possibility of importing bumblebee genetics.

MPI Investment Programmes director Steve Penno says this project could help increase the productivity of bumblebee hives dramatically.

Enhancing bumblebee activity would mean better pollination for growers, which means higher yields and better quality produce, he says.

As well as the bumblebee research, the project will also look at developing technology to rear Limonicuspredatory mites.

This mite is effective in controlling thrips, whiteflies, and other mites in greenhouses and protected culture systems.

While it occurs naturally in New Zealand, it is currently only reared overseas and is re-imported for New Zealand growers.

This is expensive, time-consuming, and theres always the risk of supply shortages, says Dr Gera.

If we can successfully rear these mites for commercial production and release them in New Zealand it will be far more cost-effective to control pests.

Excerpt from:
New study aims to increase longevity of bee hives - The Bay's News First - SunLive

Read More...

Lee Westwoods longevity at the top his greatest achievement – Yorkshire Post

December 16th, 2020 9:56 pm

SportOther SportThe longevity of the career is staggering.

Sunday, 13th December 2020, 2:49 pm

Lee Westwood may never have won a major the best player never to do so dare we say but even that must now be rendered inconsequential given this latest achievement.

Twenty years after winning the European Tours money list for the first time, and 11 years after claiming it for a second time, the 47-year-old from Worksop topped the Order of Merit for a third occasion in the Middle East yesterday.

The Race to Dubai it might now be known, but how the evergreen Westwood outran athletes half his age over the marathon of a season is a testament to his everlasting durability.

Granted, it was a season truncated by coronavirus, but still. This has to be Westwoods crowning glory, eclipsing even November 2010 when he rose to No 1 in the world rankings.

Eclipsing his first Order of Merit title, surely, when he ended Colin Montgomeries seven-year stranglehold over the European Tour.

Even then, that first Harry Vardon Trophy for Europes premier player, would have been his earlier had it not been for Montgomerie, with Westwood winning 12 times over a three-year span from 1998.

His first win came in 1996. Earlier this year the man who honed his skills at Worksop Golf Club achieved a victory in four different decades.

There have been lean years, notably a spell after the turn of the millennium when he plummeted to a position outside the top 250 in the world, but that he scaled the mountain top eventually a deceade ago now says much about his resolve.

Not many golfers can operate at the top level for the best part of a quarter of a century. For every Tiger Woods and Phil Mickelson on the PGA Tour, who can match Westwood for longevity, there is a David Duval, Vijay Singh or Jason Dufner, men who enjoyed spells but faded.

Watching it all unfold yesterday was Billy Foster, for so long Westwoods caddie but now carrying the bag for Sheffields Matt Fitzpatrick, the only man to go lower than Westwood in Dubai.

Foster will have been the first to join Westwood for a celebratory drink.

Support The Yorkshire Post and become a subscriber today. Your subscription will help us to continue to bring quality news to the people of Yorkshire. In return, youll see fewer ads on site, get free access to our app and receive exclusive members-only offers. Click HERE to subscribe.

Read more:
Lee Westwoods longevity at the top his greatest achievement - Yorkshire Post

Read More...

B Vitamins: What are they and how can they help? – Longevity LIVE – Longevity LIVE

December 16th, 2020 9:56 pm

We all know that good nutrition is linked to good health. Vitamins are a vital part of the equation and B vitamins are essential for preventative care (1). They can aid in promoting a healthy metabolism (1) and are also linked to reducing the risk of stroke (1) (2) (3).

Vitamin B complex comprises eight B vitamins. These include Vitamin B-1 (thiamine) (4), B-2 (riboflavin) (5), B-3 (niacin) (6), B-5 (pantothenic

acid) (7), B-6 (pyridoxine) (8), B-7 (biotin) (9), B-9 (folate or *folic acid) (10) and B-12 (cobalamin) (11). They are key to a healthy body and regulate energy levels, brain function, and cell metabolism (12).

If you enjoy a varied and balanced diet, it is unlikely that youll be vitamin B deficient. Of all the B vitamin deficiencies, B-12 deficiency is the most common.

According to Jennifer Brown (Ph.D.) for Everyday Health (1) symptoms of a B-12 deficiency include:

People who experience this deficiency often experience depression, anxiety, and mood swings(1). Folate (also known as vitamin B-9 or *folic acid) is at the forefront of mood management(1). Findings have shown that many people who battle depression have a lower level of folate present in their blood (1) (12) (13).

B vitamins are key for a healthy body and have a direct impact on your health, energy levels, brain function, and cell metabolism (12). Cell metabolism is a set of chemical reactions that occur in living organisms in order to maintain life (13).

If youre looking to regulate and possibly improve your mood. Folate (vitamin B-9 or *folic acid) is found in: green leafy vegetables, beans, peas, peanuts, and other legumes, and citrus fruits (1).

Foods that contain high levels of vitamin B are

Specifically, salmon is low in mercury as well as being a great source. Salmon is high in riboflavin, niacin, B6, and B12(14).Its also a good source of vitamin B-1 (thiamine) and vitamin B-5 (pantothenic acid) (14).

They have a high B-9 (folate) content. The highest sources of folate are spinach (raw or cooked), collard greens, turnip greens, and romaine lettuce (14). Unfortunately, some of the folate is destroyed during the cooking process (14). This can be lost in the water when boiling. The best course of action is to steam them until they are partway between tender and crisp (15).

Liver and organ meats are admittedly, not particularly popular. However, they contain loads of vitamin B. If you are a meat eater and can stomach liver, this could be a great way to supplement your intake (14).

According to Healthline (14) one large egg contains 33% of the RDI for biotin. This is spread equally between the yolk and the white. So, in order to get as much biotin as possible, its best to eat the whole egg. Be aware that raw egg whites contain avidin which is a protein that prevents the absorption of biotin into the body. Eggs also contain small amounts of other B vitamins including B-2, B-5, b-7, B-9, and B-12 (14).

Just 8oz or. 240 ml of milk provides 26% of the RDI for riboflavin (14). Milk and other dairy products are usually the top sources of riboflavin (B-2) in peoples diets (16). This is followed by meat and grains (16). Milk is also a great source of cobalamin (B-12) (14). B-12 is also absorbed most efficiently through the milk and dairy products. Studies have shown absorption rates of 5179% (14).

All meat is a good source for vitamin B, but studies have shown that beef is best (14). Overall, meat and associated products are the main sources of thiamine, niacin, and pyridoxine (14) (17). Beef specifically though, boasts very high levels of B3, B6, and B12. A 3.5 oz or 100g serving provides about a third of the RDI for each of these vitamins (14).

These are a great source of both vitamin B-12 (cobalamin) and B-2 (riboflavin). In fact, oysters, clams, and mussels each contain at least four times the RDI for vitamin B12 per serving (14) (18).

Having good levels of B vitamins is great for your body. Maintaining proper levels of folate (B-9 or folic acid) can help to improve mood and reduce mood swings. This is a great one to increase if you battle with PMS (pre-menstrual syndrome). Making sure that you eat a balanced diet whether you are vegan, vegetarian, pescatarian or a meat-eater is vital when it comes to maintaining levels. Increasing your intake of green leafy vegetables is always a good idea. Just make sure not to overcook them. If you can stomach oysters, mussels, clams and/or liver, its a fabulous source of B vitamins. Its also worth noting that youre **unlikely to get too much in your diet. B vitamins are water-soluble and so any excess will be excreted through your urine (14).

*Folic acid is the synthetic form of folate which is found in supplements and fortified foods (1)

**Please see your doctor if any of the following symptoms develop. This could mean you have overdosed on vitamin B complex: excessive thirst, skin conditions, blurry vision, abdominal cramps, nausea, vomiting, increased urination, diarrhea, or skin flushing (14).

Original post:
B Vitamins: What are they and how can they help? - Longevity LIVE - Longevity LIVE

Read More...

Clene Nanomedicine Presents Blinded Interim Results from RESCUE-ALS Phase 2 Study at the 31st International Symposium on ALS/MNDResults provide…

December 16th, 2020 9:55 pm

SALT LAKE CITY, Dec. 10, 2020 (GLOBE NEWSWIRE) -- Clene Nanomedicine, Inc., a clinical-stage biopharmaceutical company, today announced the presentation of blinded interim results from the Phase 2 RESCUE-ALS clinical trial investigating the effects of its lead clinical candidate, CNM-Au8, for the treatment of amyotrophic lateral sclerosis (ALS). CNM-Au8 is an aqueous suspension of clean-surfaced, faceted gold nanocrystals with catalytic activity that has been shown to enhance the metabolic energetic capacity of motor neurons while simultaneouslyreducing oxidative stress.

As of the data cutoff (October 27, 2020), the trial was fully enrolled with a preliminary blinded assessment of the studys primary endpoint, the motor neuron number index-4 [MUNIX(4)] score, showing that more than 40% of enrolled patients with completed week 12 data experienced improvements in motor neuron function assessed by MUNIX. When compared to baseline values, the average MUNIX(4) score of the overall trial population (including both active CNM-Au8 and placebo) experienced an absolute increase in mean MUNIX(4) values. This increase exceeded the expectations of the statistical modeling on which the study was based, which predicted a linear decline in average MUNIX(4) score from study onset (Neuwirth et al. JNNP 2015). These data, while blinded, suggest that CNM-Au8 may have neuro-reparative potential in ALS patients. Clene expects to report the complete, unblinded results from the RESCUE-ALS study in 2H 2021.

Although blinded to treatment assignment, these data are encouraging. We believe Clenes breakthrough approach with the application of physics to biology via direct electron interactions within cellular systems at the nano-scale may hold the potential to revolutionize the treatment of neurodegenerative diseases such as ALS and other motor neuron diseases, said Robert Glanzman, MD, FAAN, Chief Medical Officer of Clene.

Rob Etherington, President and CEO of Clene added, This blinded interim analysis suggests that CNM-Au8 is working mechanistically to address a foundational challenge common to many neurodegenerative diseases, namely that stressed or failing neurons need additional energy for their survival, repair, and improved function. Emerging MUNIX data potentially indicate preservation of motor units, which is promising. We eagerly anticipate final results and are encouraged that these blinded interim results may provide hope for ALS patients and their families as they search for new therapies to treat this devastating disease.

The presentation (CLT-23) titled, RESCUE-ALS Trial, A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of CNM-Au8 to Slow Disease Progression in Amyotrophic Lateral Sclerosis Patients: Design and Interim Blinded Results, is available as a live e-Poster on December 10th at 12:10 12:50 pm EST at the Virtual 31st International Symposium on ALS/MND, held online (https://symposium.mndassociation.org/virtual-2020/).

About RESCUE-ALSRESCUE-ALS is a Phase 2 multi-center, randomized, double-blind, parallel group, placebo-controlled study examining the efficacy, safety, pharmacokinetics and pharmacodynamics of CNM-Au8 in participants who are newly symptomatic with ALS (within 24-months of screening or 12-months from diagnosis). Enrolled subjects will be randomized 1:1 to receive either active treatment with CNM-Au8 (30 mg) or placebo in addition to their current standard of care. Participants will receive their randomized treatment over 36 consecutive weeks during the treatment period. The objective of this study is to assess the impact of improving neuronal bioenergetics, reducing reactive oxygen species and promoting protein homeostasis with CNM-Au8 to slow disease progression in patients with ALS. In the trial, efficacy is assessed as the average change in motor neuron unit number index (MUNIX) estimated by electromyography for the abductor digiti minimi (ADM), abductor pollicis brevis (APB), biceps brachii (BB), and tibialis anterior (TA) (muscles of the hand, arm, and leg). The trial was fully enrolled with 44 participants as of the reported 27-October-2020 data cut. Baseline characteristics include [mean (SD)], MUNIX(4) score: 93.7 (45.8); FVC % predicted: 80.8 (16.3); ALSFRS-R: 38.6 (6.1); ALSSQOL-20: 3.3 (1.3), mean time from diagnosis: 4.7 (4.6) months; riluzole background treatment, 92%.

About CNM-Au8CNM-Au8 is a concentrated, aqueous suspension of clean-surfaced faceted gold nanocrystals that act catalytically to support important intracellular biological reactions. CNM-Au8 consists solely of pure gold nanoparticles, composed of clean-surfaced, faceted, geometrical crystals held in suspension in sodium bicarbonate buffered, pharmaceutical grade water. CNM-Au8 has demonstrated safety in Phase 1 studies in healthy volunteers and has shown both remyelination and neuroprotective effects in multiple preclinical (animal) models. Preclinical data, both published in peer-reviewed journals and presented at scientific congresses, demonstrate that treatment of neuronal cultures with CNM-Au8 improves survival of neurons, protects neurite networks, decreases intracellular levels of reactive oxygen species and improves mitochondrial capacity in response to cellular stresses induced by multiple disease-relevant neurotoxins. Oral treatment with CNM-Au8 improved functional behaviors in rodent models of ALS, multiple sclerosis, and Parkinsons disease versus vehicle (placebo). CNM-Au8 is currently being tested in a Phase 2 clinical study for the treatment of chronic optic neuropathy in patients with MS in addition to Phase 2 and Phase 3 clinical studies for disease progression in patients with ALS.

About ALSALS is a universally fatal neurodegenerative disorder that results in loss of motor neurons in the cerebral cortex, brain stem, and spinal cord. ALS, also known as Lou Gehrig's disease, leads to the death of the neurons controlling voluntary muscles resulting in weakness, muscle atrophy, and progressive paralysis. ALS affects more than 15,000 patients in the United States and is the most prevalent adult-onset progressive motor neuron disease.

About CleneClene is a clinical-stage biopharmaceutical company focused on the development of unique therapeutics for neurodegenerative diseases. Clene has innovated a novel nanotechnology drug platform for the development of a new class of orally administered neurotherapeutic drugs. Clene has also advanced into the clinic an aqueous solution of ionic zinc and silver for anti-viral and anti-microbial uses. Founded in 2013, the company is based in Salt Lake City, Utah with R&D and manufacturing operations located in North East, Maryland. For more information, please visit http://www.clene.com.

Forward-Looking StatementsThis press release contains, and certain oral statements made by representatives of Tottenham, Clene, and their respective affiliates, from time to time may contain, "forward-looking statements" within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. Tottenham's and Clene's actual results may differ from their expectations, estimates and projections and consequently, you should not rely on these forward-looking statements as predictions of future events. Words such as "expect," "estimate," "project," "budget," "forecast," "anticipate," "intend," "plan," "may," "will," "could," "should," "believes," "predicts," "potential," "might" and "continues," and similar expressions are intended to identify such forward-looking statements. These forward-looking statements include, without limitation, Tottenham's and Clene's expectations with respect to future performance and anticipated financial impacts of the business combination, the satisfaction of the closing conditions to the business combination and the timing of the completion of the business combination. These forward-looking statements involve significant risks and uncertainties that could cause actual results to differ materially from expected results. Most of these factors are outside the control of Tottenham or Clene and are difficult to predict. Factors that may cause such differences include, but are not limited to: (1) the occurrence of any event, change or other circumstances that could give rise to the termination of the Merger Agreement relating to the proposed business combination; (2) the outcome of any legal proceedings that may be instituted against Tottenham or Clene following the announcement of the Merger Agreement and the transactions contemplated therein; (3) the inability to complete the business combination, including due to failure to obtain approval of the shareholders of Tottenham or other conditions to closing in the Merger Agreement; (4) delays in obtaining or the inability to obtain necessary regulatory approvals (including approval from regulators, as applicable) required to complete the transactions contemplated by the Merger Agreement; (5) the occurrence of any event, change or other circumstance that could give rise to the termination of the Merger Agreement or could otherwise cause the transaction to fail to close; (6) the inability to obtain or maintain the listing of the post-acquisition company's ordinary shares on NASDAQ following the business combination; (7) the risk that the business combination disrupts current plans and operations as a result of the announcement and consummation of the business combination; (8) the ability to recognize the anticipated benefits of the business combination, which may be affected by, among other things, competition, the ability of the combined company to grow and manage growth profitably and retain its key employees; (9) costs related to the business combination; (10) changes in applicable laws or regulations; (11) the possibility that Clene or the combined company may be adversely affected by other economic, business, and/or competitive factors; and (12) other risks and uncertainties to be identified in the Form S-4 filed by Chelsea Worldwide (when available) relating to the business combination, including those under "Risk Factors" therein, and in other filings with the Securities and Exchange Commission (SEC) made by Tottenham and Clene. Tottenham and Clene caution that the foregoing list of factors is neither exclusive nor exhaustive. Tottenham and Clene caution readers not to place undue reliance upon any forward-looking statements, which speak only as of the date made. Neither Tottenham or Clene undertakes or accepts any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements to reflect any change in its expectations or any change in events, conditions or circumstances on which any such statement is based, subject to applicable law. The information contained in any website referenced herein is not, and shall not be deemed to be, part of or incorporated into this press release.

Media ContactAndrew MielachLifeSci Communications(646) 876-5868amielach@lifescicomms.com

Investor ContactBruce MackleLifeSci Advisors, LLC(929) 469-3859bmackle@lifesciadvisors.com

See original here:
Clene Nanomedicine Presents Blinded Interim Results from RESCUE-ALS Phase 2 Study at the 31st International Symposium on ALS/MNDResults provide...

Read More...

Global Nanomedicine market 2020- Industry Overview, Global Trends, Market Analysis, CAGR Values and Country Level Demand To Forecast by 2027 -…

December 16th, 2020 9:55 pm

Global Nanomedicine market Industry Trends and Forecast to 2027 New Research Report Added to Databridgemarketresearch.com database. The report width Of pages : 350 Figures: 60 And Tables: 220 in it. To build an influential report, detailed market analysis has been conducted with the inputs from industry experts. By working on a number of steps for collecting and analysing market data, this supreme market research report is prepared with the expert team. It describes various definitions and segmentation or classifications of the industry, applications of the industry and value chain structure. Businesses can obtain a complete knowhow of general market conditions and tendencies with the information and data involved in the credible Global Nanomedicine market business report. The foremost areas of market analysis such as market definition, market segmentation, competitive analysis and research methodology are looked upon very vigilantly and precisely throughout the report.

Global nanomedicine market is registering a healthy CAGR of 15.50% in the forecast period of 2019-2026. This rise in the market value can be attributed to increasing number of applications and wide acceptance of the product globally. There is a significant rise in the number of researches done in this field which accelerate growth of nanomedicine market globally.

Get Sample Report + All Related Graphs & Charts @ https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-nanomedicine-market

Key Market Competitors

Few of the major market competitors currently working in the global nanomedicine market are Abbott, Invitae Corporation, General Electric Company, Leadiant Biosciences, Inc., Johnson & Johnson Services, Inc., Mallinckrodt, Merck Sharp & Dohme Corp., NanoSphere Health Sciences, Inc., Pfizer Inc., CELGENE CORPORATION, Teva Pharmaceutical Industries Ltd., Gilead Sciences, Inc., Amgen Inc., Bristol-Myers Squibb Company, AbbVie Inc., Novartis AG, F. Hoffmann-La Roche Ltd., Luminex Corporation, Eli Lilly and Company, Nanobiotix, Sanofi, UCB S.A., Ablynx among others.

Competitive Landscape

Global nanomedicine market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of nanomedicine market for global, Europe, North America, Asia-Pacific, South America and Middle East & Africa.

Key Insights in the report:

Complete and distinct analysis of the market drivers and restraints

Key Market players involved in this industry

Detailed analysis of the Market Segmentation

Competitive analysis of the key players involved

Market Drivers are Restraints

Grab Your Report at an Impressive 30% Discount! Please click Here @ https://www.databridgemarketresearch.com/request-a-discount/global-nanomedicine-market

Market Segmentation:-

By Product Type

By Application

By Indication

By Modality

To comprehend Global Nanomedicine market dynamics in the world mainly, the worldwide Nanomedicine market is analyzed across major global regions.

Actual Numbers & In-Depth Analysis, Business opportunities, Market Size Estimation Available in Full Report.

Some of the Major Highlights of TOC covers:

Chapter 1: Methodology & Scope

Definition and forecast parameters

Methodology and forecast parameters

Data Sources

Chapter 2: Executive Summary

Business trends

Regional trends

Product trends

End-use trends

Chapter 3: Industry Insights

Industry segmentation

Industry landscape

Vendor matrix

Technological and innovation landscape

For More Insights Get Detailed TOC @ https://www.databridgemarketresearch.com/toc/?dbmr=global-nanomedicine-market

Nanomedicine Market report effectively provides required features of the global market for the population and for the business looking people for mergers & acquisitions, making investments, new vendors or concerned in searching for the appreciated global market research facilities. It offers sample on the size, offer, and development rate of the market. The Nanomedicine report provides the complete structure and fundamental overview of the industry market.

Note: If you have any special requirements, please let us know and we will offer you the report as you want.

About Data Bridge Market Research:

Data Bridge Market Research set forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market. Data Bridge endeavors to provide appropriate solutions to the complex business challenges and initiates an effortless decision-making process.

Contact:

Data Bridge Market Research

US: +1 888 387 2818

UK: +44 208 089 1725

Hong Kong: +852 8192 7475

Email: Corporatesales@databridgemarketresearch.com

See the original post here:
Global Nanomedicine market 2020- Industry Overview, Global Trends, Market Analysis, CAGR Values and Country Level Demand To Forecast by 2027 -...

Read More...

NHMRC awards Griffith University $4.5 million in research funding – Griffith News

December 16th, 2020 9:55 pm

Key Griffith University research projects have received $4.5 million in funding from the National Health and Medical Research Council.

Announced on December 15 by the Federal Minister for Health, The Honorable Greg Hunt MP, the seven Ideas Grants projects will contribute to vital health and medical research.

Deputy Vice Chancellor (Research) Professor Mario Pinto said the funding highlights the extraordinary work conducted by the Universitys researchers in addressing major societal health challenges.

These projects have the potential to make a significant difference to peoples health and wellbeing. I extend my congratulations and appreciation to all staff who have contributed to these efforts.

More than half the funding for Griffith University was awarded to projects within theInstitute for Glycomics, withfour research projects securing $2.56 million to explore a super vaccine that tackles bothinfluenza virus andGroup A Streptococcus bacteria and other vaccine development projects that tackle other clinically important bacterial infections.

Institute Director Professor Mark von Itzstein AO said the awards cemented the Institutes reputation as a leading biomedical research institute.

Our institute is focussed on translational research outcomes that diagnose, prevent and treat diseases of global impact. These grants will significantly assist our researchers to deliver on our mission to achieve a disease-free world.

NHMRC Ideas

Dr Mehfuz Zaman, Professor Mark von Itzstein and Professor Michael Good (Institute for Glycomics) awarded $707, 717 for the project Vaccine to prevent Influenza Virus and Bacterial superinfection (Associate Professor Victor Huber, University of South Dakota).

Associate Professor Kate Seib, Professor Michael Jennings and Dr Arun Everest-Dass (Institute for Glycomics) awarded $826,490 for the project Gonococcal vaccine development guided by a cross-protective meningococcal vaccine (Dr Caroline Thng, Gold Coast Health).

Dr Freda Jen, Associate Professor Kate Seib, Professor Michael Jennings and Dr Milton Kiefel (Institute for Glycomics) awarded $526,949.6 for the project Targeting a bacterial glycol-Achilles heel to make new vaccines for Haemophilus influenzae and Neisseria gonorrhoeae.

Professor Michael Jennings, Associate Professor Thomas Haselhorst, Dr Lucy Shewell, Dr Christopher Day (Institute for Glycomics) awarded $608,425 for the project Structure and biophysical analysis aided design of novel toxoid vaccines for a major class of bacterial toxins (Prof James Paton, The University of Adelaide, Prof Mark Walker, The University of Queensland and Prof Victor Torres, New York University).

Dr David Lloyd, Dr Claudio Pizzolato, Dr David Saxby and Dr Laura Diamond (Menzies Health Institute Queensland) awarded $860, 231 for the project Osteoarthritis compass: Predicting personalized disease onset and progression with future capacity for clinical use (Dr Michelle Hall, Assoc Prof Adam Bryant University of Melbourne, Prof David Hunter, University of Sydney; Prof Juha Toyras, Dr Shekhar Chandra, Assoc Prof Craig Engstrom The University of Queensland; Dr Jurgen Fripp, CSIRO Australian e-Health Research Centre; Prof Rami Korhonen, University of Eastern Finland).

Professor Heidi Zeeman, Dr David Painter and Professor Elizabeth Kendall (Menzies Health Institute Queensland) awarded $513, 483 for the project Dimensional Attention Modelling for Neglect Detection (DIAMOND): A novel application for brain injury (Prof Julie Bernhardt, Florey Institute of Neuroscience and Mental Health).

Associate Professor Hang Ta (Queensland Micro and Nanotechnology Centre/GRIDD) awarded $523, 342 for the project Developing smart nanomedicine to enable advanced diagnosis and stimuli-responsive treatment for atherosclerosis and thrombosis (Dr Nghia Truong Phuoc, Monash University; Dr Gary Cowin, Dr Nyoman Kurniawan, Prof Zhiping Xu, The University of Queensland and Prof Karlheinz Peter, Baker Heart and Diabetes Institute).

Griffith researchers involved in research led by other institutions

NHMRC Ideas

Prof Randipsingh Bindra, Dr Mo Chen, Assoc Prof James St John, Assoc Prof Jenny Ekberg, Dr Brent McMonagle (Griffith Health) are part of a team led by Assoc Prof Jeremy Crook (University of Wollongong) awarded $805,064.45 for the project titled A wireless electric nerve-guide for peripheral nerve repair (Dr Eva Tomaskovic-Crook, University of Wollongong).

Assoc Prof Joshua Byrnes (MHIQ, Health) is part of a team led by Assoc Prof Maree Toombs (The University of Queensland) awarded $1,279,602.45 for the project titled Advancing equitable and non-discriminatory access to health services for First Nations peoples: A multidisciplinary Queensland Human Rights Act case study (Dr Shivashankar Hiriyur Nagaraj, Queensland University of Technology; Jodie Luck, Mr DanielWilliamson, Queensland Health; Mr Jed Fraser, Queensland Aboriginal and Islander Health Council; Prof Anthony Smith, Dr Claire Brolan Dr Caitlin Curtis, Dr Sandra Creamer, Prof Wendy Hoy, Dr Amelia Radke (The University of Queensland), Dr Kelly Dingli (Queensland Aboriginal and Islander Health Council); Mr Gregory Pratt (The Council of the Queensland Institute of Medical Research)

ARC Linkage 2020 Round 1

Dr Pooja Sawrikar (School of Human Services and Social Work) is part of a Western Sydney University project led by Assoc Prof Rebekah Grace awarded $387,107 for the project Upholding the right to cultural connection for children in care.

More:
NHMRC awards Griffith University $4.5 million in research funding - Griffith News

Read More...

COVID-19 And Diabetes Can Be A Dangerous Mix – WFYI

December 16th, 2020 9:54 pm

FARAH YOUSRY - Side Effects Public Media

Agatha Walston leads a busy life. Shes a nurse in southern Indiana and a single mother of two young kids.

Shes kept control of her type 1 diabetes for over 28 years partly through a healthy lifestyle. I would rather snack on veggies than trash food, the Clarksville woman says.

But when the pandemic hit, she feared that the control she maintained for so long could be unraveling. I told my kids, I said, Okay, there's this super-killer virus on the loose, and I'm a nurse and I will probably get it.

That was really hard conversation to have with the kids to make sure that they knew that, you know, if mom goes, they're still going to have each other.

People living with diabetes are not more likely to get COVID-19. But they are at a much greater risk of developing severe symptoms and complications. A COVID study in England examined more than 20,000 deaths and found that a third of those people were diabetic.

In mid-April, Walston tested positive.

She survived without hospitalization, but months later, she noticed new health issues. She was diagnosed with high cholesterol, elevated blood pressure, heart problems and glaucoma a condition that could cause blindness.

She recalls, The glaucoma specialist, he had said, You know, you're already at risk for glaucoma. So we won't know if it was COVID or diabetes.

Walstons doctors are unsure if COVID is behind any of these complications or if her diabetes was a contributing factor.

But many diabetics worldwide are battling health complications from a COVID infection.

Even if your blood glucose control is perfect, you're still going to have some risks, says Dr. Carmella Evans-Molina, director of the Diabetes Research Center at Indiana University.

COVID has the power to elevate blood sugar levels and cause insulin resistance even in previously healthy people, she says. For diabetics, this effect is magnified.

So they might then need to make changes in their insulin regimen or changes in their diabetes medication, Evans-Molina says. If they're in the hospital, obviously their providers in the hospital will be taking care of these things. But if they're recovering from COVID at home, they need to be very careful and checking their blood glucose very frequently, and then be in communication with their doctors.

She says that such drastic changes in blood sugar levels could cause long-term complications if not managed carefully.

Dr. Francisco Rubino, a professor at Kings College London, also has been watching the emerging problem. Since the beginning of the pandemic, we noticed there is a bidirectional relationship between COVID and diabetes.

In a letter to the New England Journal of Medicine, he and other healthcare professionals noted that the severe insulin resistance caused by COVID might have another shocking effect. Even people who didn't have any history of diabetes, coming up to the hospital with clear signs of having diabetes, he says.

Rubino says data is still limited, so he set up a global registry called CoviDiab to track these cases.

Dr. Evans-Molinas team has studied pancreatic cells of patients who died from COVID. They did not see evidence of the virus being able to trigger new on-set diabetes, she says, adding, I think we're really early in our understanding of that.

She notes that managing COVID patients requires the use of steroids, which causes elevated blood sugar levels. This is one of many factors that could have damaging effects on diabetics or someone with pre-diabetes.

So we know that we're probably seeing people who were very close to a diagnosis pass over that threshold and become diagnosed with diabetes, she says.

As doctors and scientists work to understand the relationship between COVID and diabetes, Walston is dealing with her medical problems. She says this year has been rough physically and emotionally.

She adds, The best thing about 2020 [is] not dying.

This story was produced by Side Effects Public Media, a news collaborative covering public health.

This reporting is supported by the GBH Educational Foundation through the Corporation for Public Broadcasting. To learn more about the diabetes epidemic in America, watch the documentary"Blood Sugar Rising."

Here is the original post:
COVID-19 And Diabetes Can Be A Dangerous Mix - WFYI

Read More...

Kids With Type-1 Diabetes Helped by Anti-TNF Therapy – ubmd.com

December 16th, 2020 9:54 pm

A research study led by Teresa Quattrin, MD, could prove beneficial for children and young adults with newly-diagnosed Type 1 diabetes.

Published December 16, 2020

A Phase 2 research study led by Teresa Quattrin, MD, UB Distinguished Professor of pediatrics and senior associate dean for research integration, shows that the drug golimumab preserves beta-cell function in children and young adults with newly-diagnosed Type 1 diabetes for at least a year after diagnosis.

Research Published in New England Journal of Medicine

The study published on Nov. 19 in The New England Journal of Medicine represents a major step forward in the effort to find ways to preserve the insulin-making capabilities of children and young adults newly diagnosed with Type 1 diabetes.

The study demonstrates that golimumab, an anti-tumor-necrosis-factor (TNF) therapy, reduced the amount of injected insulin required by children and young adults with newly-diagnosed Type 1 diabetes by preserving their ability to produce insulin on their own, called endogenous insulin.

The need for less injected insulin is a major quality of life improvement for patients with Type 1 diabetes, according to the researchers.

Golimumab, marketed as Simponi, is currently used in the treatment of rheumatoid arthritis, ulcerative colitis and other autoimmune conditions. However, it is not approved by the U.S. Food and Drug Administration for the treatment of Type 1 diabetes.

Quattrin, first author on the study, also presented the findings on June 13 at the annual meeting of the American Diabetes Association (ADA).

The most important finding of our work is that this drug, golimumab, is a potential disease-modifying agent for newly diagnosed Type 1 diabetes, says Quattrin, attending pediatric endocrinologist at the Diabetes Center atUBMD PediatricsandOishei Childrens Hospital. The main goal of the study was to see if golimumab could preserve beta-cell function in these newly-diagnosed patients and it does.

This was assessed by measuring the amount of C-peptide in patients blood during a four-hour mixed meal tolerance test. Because C-peptide reflects only insulin made by the body and not injected insulin, C-peptide levels reveal how well the pancreas is producing insulin.

Higher C-Peptide Levels After 1 Year

Patients treated with golimumab had a higher C-peptide level at week 52 compared to placebo.

This was statistically significant; thus the study met its primary goal, Quattrin says.

Quattrin adds that 41.1 percent of participants receiving golimumab had an increase or a less than 5 percent decrease in C-peptide compared to only 10.7 percent in the placebo group.

Nearly 43 percent of those who received golimumab were in partial diabetes remission (also known as the honeymoon phase) versus 7.1 percent of those receiving placebo. The definition of partial remission was based on insulin dose and blood sugar control levels as indicated by hemoglobin A1C, a measurement of average blood sugar levels over three months.

Blood Sugar Control With Less Insulin

Quattrin explains that a child with Type 1 diabetes requires about 1 unit of insulin per kilogram of body weight per day. That means that a child weighing about 65 pounds typically requires about 30 units of injected insulin per day once they are out of the partial remission period about 3 to 6 months after diagnosis.

In this study, both golimumab and placebo groups achieved good blood sugar control, but patients treated with golimumab achieved it with less insulin, Quattrin says.

During the 52 weeks, insulin dose increased only slightly for those on golimumab 0.07 units per kilogram per day versus 0.24 units per kilogram per day for those on placebo study.

In a post-hoc analysis an analysis conducted after the conclusion of the clinical trial those younger than 18 years had 36 percent fewer episodes where blood sugar was less than 54 mg per deciliter, designated by the ADA as level 2 hypoglycemia.

This is important clinically because low blood sugar reactions are dangerous and can even be fatal if untreated. Low blood sugar levels also require immediate attention, often causing the child to be removed from classroom or recreation activities, compromising quality of life.

UMBD Pediatrics, Oishei Among Trial Sites

The drug is self-administered as a subcutaneous injection every two weeks. No serious side effects related to the study drug such as serious infections were reported.

The randomized, controlled clinical trial was conducted at 27 centers throughout the U.S., including at theDiabetes Center at UBMD Pediatrics andOishei Childrens Hospital in Buffalo. It involved 84 patients, ages 6 to 21 years, with two-thirds receiving golimumab and one-third receiving placebo starting within 100 days from diagnosis.

Throughout three decades as a leading researcher in pediatric endocrinology, Quattrin has been interested in finding ways to extend the remission, or honeymoon period, to preserve the ability of recently diagnosed Type 1 diabetes patients to continue to make insulin on their own.

The current study took place on the basis of positive findings in animal models, as well as Quattrins work with patients treated at the Diabetes Center at UBMD Pediatrics and Oishei Childrens Hospital. It confirms results published by her team in 2009 where in a randomized pilot study 10 patients received another TNF inhibitor and eight received placebo starting within 28 days from diagnosis.

The results of this small proof-of-concept study strongly suggested that this class of drugs might be able to preserve beta-cell function in newly diagnosed patients with Type 1 diabetes.

Jacobs School Faculty Are Sub-Investigators

Jacobs School of Medicine and Biomedical SciencesDepartment of Pediatrics sub-investigators in the research are:

They were supported by the pediatric diabetes-endocrinology research team at the Diabetes Center at UBMD Pediatrics and Oishei Childrens Hospital, led by Amanda House.

Other co-authors of the research presented at the ADA and on the New England Journal of Medicine paper were from Emory University, the University of Colorado, the University of Florida and Janssen Research & Development LLC. The World Without Disease Accelerator a group within Janssen funded the study.

Read more from the original source:
Kids With Type-1 Diabetes Helped by Anti-TNF Therapy - ubmd.com

Read More...

A Definitive Guide to Wine and Type 1 Diabetes – Healthline

December 16th, 2020 9:54 pm

It didnt take long into her adult years for Julia Blanchette, a nurse and diabetes educator at the Cleveland Clinic, to discover shes a wine enthusiast.

The fact that she has celiac disease pushed her toward it in the first place, because she was steering clear of wheat-based beer, she said. And the fact that she has type 1 diabetes (T1D) need not have dissuaded her. With a lot of (fun) sampling and trial and error, Blanchette learned how to embrace her love of wine, she tells DiabetesMine.

It took experimentation for sure. I had to find the wines that didnt raise my blood sugar as much, and I savor the ones that do as more of a dessert, she says.

And once I found the ones that didnt impact my blood sugar immediately, I had to understand how it impacted me later. Did it make me low? Did I have to always eat with it? Did it make me high? Whatever the answer, she says, each one led her to be a confident wine connoisseur who happens to have T1D on board.

Such can be the case for most people with diabetes (PWDs). With study, thought, and guidance from your medical team, experts say theres no reason not to savor the art and joy of wine.

The first thing PWDs need to know about wine is how it works in the body, which does differ a bit from other types of alcohol.

Wine, unlike, say, vodka or beer, is created very much by the hand and mood of nature.

Thats why there are good years and not so good years for wine production.

That dynamic means that even the same wine can vary a bit from season to season.

Thats one of the things about wine, and it goes across every type, Keith Wallace, author, winemaker, sommelier, and a professor and founder of the Wine School of Philadelphia tells DiabetesMine.

Sugar gets fermented, yes, but you are going to find hidden sugar in there, and with wine, it can sometimes be a significant amount, he says.

As a winemaker, I always insist on fermenting everything bone dry so its not as much an issue, he explains.

Wallace does that for his clients, yes. But he does it for himself too. Diagnosed with type 2 diabetes some years ago, he quickly realized that the dryer the wine, the less impact on his glucose readings.

But that doesnt mean PWDs need to limit their wine choices, he says. Rather, understanding the possible impact and what action to take to make it work is the key, he says.

What do doctors say about consuming wine with diabetes? Often not enough, according to Mary Ellen Phipps, registered dietitian nutritionist, founder of MilkAndHoneyNutrition.com, and author of The Easy Diabetes Cookbook. Phipps has lived with T1D since age 5.

There are two camps, generally, she tells DiabetesMine. The doctor who says no, dont drink alcohol at all, and the doctor who says its fine. But heres the thing: They tend to say that with no explanation, without putting a framework of understanding of it for the person with diabetes.Her suggestion? Ask the question and then ask for more details.

Her opinion?

If you are going to drink, wine is a good choice.

Unlike, say, vodka, when you can pretty much know the impact on your blood sugars no matter the brand, wines vary greatly.

Understanding that can help a person with diabetes plan and study it as they begin.

When Phipps advises patients, she speaks of what she knows, not just as a trained nutritionist but as a person living with T1D who also happens to love wine.

Her basic breakdown of wine and blood sugars? A dry white has the least sugar, reds come in a bit higher (but theres no need to avoid them she says) and dessert wines are just like they sound.

Wallace breaks them down like this:

Lower alcohol wines often have more sugar for taste reasons, he said. And so do lower-cost wines, which, he said, are often amped up in sugar for taste reasons.

That, he said, is because the pedestrian wine drinker tends to lean toward sweeter, having not learned the nuances of wine tastes.

A surprise, though: The same can go for a moderately expensive wine.

Theyre trying to appeal to that same general consumer, just a wealthy one, he explains.

To look for a wine with the right alcohol content, he says, look for a label that reads 12.5 percent to 16 percent alcohol. More or less than that can mean added sugars.

As for types, he said, the location of the grape grown can give you hints as well.

Germany, he said, is known for Rieslings, which have a higher sugar content by design. But they also have wines with almost no sugar, known as Trocken (dry).

It has to say that, he says, and it has to say Trocken by itself on the label.

Italian and French wines tend to have less residual sugar overall, he says, because its a cultural thing. Countries that tend to pair wines with food usually make wines with less sugar.

Australian wine drinkers, he says, tend to drink it by itself, and therefore tend toward a bit more sugar.

The modern styles of white wines, Wallace says, (other than Chardonnay) are light, fresh, crisp styles. Those actually have almost no sugar at all.Another hint for hidden sugar? Ironically, Wallace says, it can be the popularity of the brand.

Were seeing this more with, for example, the popularity of Oregon wines, he says. As wines like Pinot Noir get more popular, you often see more sugar. People like it; its as simple as that.

Karen Graham, registered dietitian, diabetes educator, and author of three best-selling books on living with diabetes, is also a wine lover who happens to live a stones throw from vineyards in British Columbia.

Her advice to the wine enthusiast with diabetes is to start with the basics and go from there.

She suggests that you hone in on a few different wine styles you like, experiment with brands, and learn what works for you. Then stick to those as much as you can.

In her book The Complete Diabetes Guide, Graham outlines the general carbohydrate/sugar content of the most popular wines, something she says can be used as a starting point for handling the wines you like best.

Be aware that when it comes to drinking alcohol of any kind, including wine, there are some steps all PWDs should take.

Make sure you never drink on an empty stomach, Graham tells DiabetesMine.

She also reminds PWDs to always have a source of fast-acting glucose on hand, because alcohol can lower blood sugars, and do so quickly.

You should also let any friends you may be enjoying wine with know about your condition, and make sure theyre familiar with the signs of a low blood sugar, which can mimic drunkenness. They should know not to hesitate to ask you about your situation should they see signs.

And, of course, you should pay close attention to your blood sugars both before, during, and for a long time after a wine outing.

With those steps handled, PWDs can enjoy wine and do so without guilt, Graham says.

Choose one or a few you really love and stick with them, or with similar selections, she adds. Going to a friends house for dinner? Bring along a bottle or two and that way you know what youre drinking. And for a restaurant, its always a good idea to peruse the wine list in advance online, to see what you can find that you like and know, or learn about one that sounds interesting ahead of time.

Phipps agrees that preparation and a bit of study makes being a wine lover with diabetes easier, even if it takes more effort upfront.

She suggests keeping a journal, which isnt as odd as it sounds. Many wine aficionados keep a journal of the wines they try. But instead of just recording what you like and why, keep track of how your blood sugars were during and after, what you may have eaten with it, and if any tweaks are needed.

Pay attention to how you respond to it, and then youll know what to choose next time, or what to do if you choose that one again, Phipps says.

And what about a wine tasting evening? Yes, Graham and Phipps agree, it can be not only done but fully enjoyed.

Phipps suggests finding out ahead of time how many ounces a vineyard or event organizer will be pouring, as well as what kinds of wine. That way, you can keep track as you go along.

Graham points out that food may not be readily available at some wine tastings, and may lean toward protein (such as cheeses) rather than carbs. So its a good idea to eat a meal before going, and/or pack some snacks just in case.

Wines with less sugar, in particular, may lower blood sugars, so being prepared is your best bet, she says.

If you should be unsure of the sugar content in a wine, Wallace offers a simple tip, one that will make you look like a true wine pro: Hold your nose for the first sip.

Sweet, sour, bitter, and salty comes from the taste buds, he says. If you block your nose and you taste sugar (as the main flavor), it will inform you that this wine has a lot of sugar.

He reminds us that its important to focus on getting the right amount of food to go along with your wine when it comes to diabetes.

Dont worry about the wine as much as the food you may eat, he says. Thats what can get you in trouble. Dont arrive hungry. Eat a small prep meal beforehand so you can totally enjoy the wine.

Wallace does have some good news: This all could get less challenging in the future. In his classes, hes teaching future winemakers and servers about how different types impact diabetes, so they can help guide consumers better.

One in six people either have diabetes of some kind or are pre-diabetic, he says. Its a huge market, and you dont want to harm your customers. And wine is good, in so many ways. PWDs have so much stress and wine is a great stress reducer. This doesnt have to be a worrisome thing. Done right, its excellent.

In the end, while extra thought is needed, PWDs who love wine say the effort is worth it.

Kelly Kunik, patient advocate and author of the popular blog Diabetesaliciousness, says nearly a lifetime of living with T1D has taught her to do what she must and know all the facts but in the end, its taught her to go with the flow, too.

I wouldnt say Im a sommelier, she tells DiabetesMine. I just like wine. But to be clear: I dont study wine for my diabetes, I study it for my palate. Sometimes a glass of wine is just a glass of wine. And thats totally okay.

See more here:
A Definitive Guide to Wine and Type 1 Diabetes - Healthline

Read More...

How to Check Blood Sugar Without a Meter: Is It Possible? – Healthline

December 16th, 2020 9:54 pm

Diabetes is a chronic condition where the body either doesnt make enough insulin or doesnt use insulin properly or both. This can lead to a higher than normal blood sugar level.

Uncontrolled blood sugar levels can lead to complications, such as:

For these reasons, its important to monitor your blood sugar if you have diabetes.

Prior to using meters, people with diabetes would monitor their blood sugar by testing their urine. This method, however, wasnt as accurate, nor did it provide real-time results.

If you self-test your blood sugar several times a day using a glucometer, or meter, it requires that you prick your finger to draw blood to test. Due to the discomfort of this method, you might look for a way to monitor your level without this tool.

If finger pricks are very bothersome for you, dont worry theres hope. Advances in blood sugar monitoring technology could mean no more finger pricks in the future.

If you have diabetes, there are several portable devices you can use to check your blood sugar level and not all of them require a finger prick.

The one device that does require a finger prick is a meter. This is the most widely available and affordable option.

To use this device, youll insert a test strip into the meter. Youll prick your finger to retrieve a sample of blood, and then place the sample on the edge of the test strip to check your blood sugar.

Glucometers are convenient because theyre small and portable, allowing you to use them anywhere. Your blood sugar results are also accurate and instant.

You can also use a continuous glucose monitor (CGM) to check your blood sugar. This is different from glucometers, which can only monitor blood sugar when you test your blood.

Continuous glucose monitoring, on the other hand, provides real-time glucose, or blood sugar, readings every few minutes. These systems involve the insertion of a tiny sensor underneath your skin (usually in the abdomen).

This sensor measures your interstitial glucose level, and then sends the information to a pager-like monitor, or an app on your phone. An alarm sounds if your blood sugar becomes too high or too low.

Even though continuous glucose monitoring systems place a sensor under the skin, most still require a finger prick at least once a day to calibrate the device.

This is less than the number of finger pricks with a glucometer, which can require four or more per day.

The Freestyle Libre system is another way to check your blood sugar. While this method has certain features in common with a CGM and a meter, it stands out for one reason: It doesnt require a finger prick.

Youll still have a tiny sensor inserted underneath your skin with the Freestyle Libre. Its different from a CGM in that you wont get continuous readings.

But, rather than prick your finger, like you would with a meter, youll use a reader to scan the sensor when you want to check your blood sugar level.

Again, urine is another way to measure sugar levels. This involves inserting a test strip into your urine. The problem, though, is that test strips can only detect sugar in your urine they cant provide an exact blood sugar reading.

Unfortunately, this method of checking blood sugar isnt convenient since youll need a container to collect the urine. Also, it only works when urine hasnt been sitting in your bladder for too long.

Fingertips have more nerve endings, so this part of the finger tends to be the most sensitive.

If you use a finger prick to check your blood sugar level, a few techniques can make the process less painful whether youre using a glucometer or a continuous glucose monitor.

Blood sugar testing is crucial to diabetes management because high or low blood sugar can cause severe complications. If too much blood sugar accumulates in your bloodstream, you can experience major complications such as:

Signs of high blood sugar include:

Signs of low blood sugar can include:

Blood sugar can fluctuate throughout the day especially after meals, after exercising, and during stressful events. So its important to carefully monitor your blood sugar and keep it within a healthy range.

A blood sugar level less than 140 milligrams per deciliter (7.8 millimoles per litre), but greater than 70 mg/dL (3.9 mmol/L) is typically considered in the target range.

You should check your blood sugar regularly, even if you arent experiencing symptoms of a high or low glucose level. Some people with high and low blood sugar dont have any symptoms.

Even though you can monitor blood sugar level with glucometers and CGMs, the future might provide additional ways to manage your diabetes.

Testing your blood sugar is crucial to diabetes management. Using a meter or continuous glucose monitoring can provide accurate results. But you might seek a pain-free method to check blood sugar.

Talk with your doctor or a certified diabetes educator. You might be a candidate for a glucose monitoring device that involves fewer finger pricks or no finger pricks.

Additionally, making a few adjustments in the way you collect your blood sample might reduce the level of pain and discomfort.

Diabetes is a life-long, chronic condition that involves careful monitoring of your blood sugar. This can prevent serious complications such as nerve damage and stroke.

Discuss options for monitoring blood sugar with your doctor to find a device that suits your comfort level.

Continued here:
How to Check Blood Sugar Without a Meter: Is It Possible? - Healthline

Read More...

Dexamethasone study provides insight into COVID-19 treatment for patients with diabetes, other risk factors – University of Virginia The Cavalier…

December 16th, 2020 9:54 pm

A team of scientists, which included University researchers, found that dexamethasone, a steroid used to treat severe cases of COVID-19, is less effective to treat COVID-19 for those with diabetes and other risk factors. The discovery suggests that further research is necessary to understand how to better treat diabetic and at-risk patients with COVID-19.

Dexamethasone is an anti-inflammatory and immunosuppressive steroid used to treat critically-ill, COVID-19 patients who require supplemental oxygen or ventilators. The steroid suppresses the immune system, alleviating the damage done to the lungs in patients with an overactive immune response, a bodily response that can be deadly. Besides COVID-19, dexamethasone has been used to treat severe pneumonia, asthma and other conditions.

What makes this paper special is that there arent that many drugs that are proven to treat COVID-19, said Dariusz Brzezinski, University Medical School research scientist and team member. Thats why dexamethasone is interesting because its been proven to help those severe cases.

For their research, scientists from the University School of Medicine, University of South Carolina and Poland relied on the LabDB Laboratory Information Management System, a database that tracks the structures of proteins. One such plasma protein, serum albumin, is known to transport drugs throughout the bloodstream, including dexamethasone. Serum albumin has different active sites to which drugs can bind in order to be carried throughout the body.

Wladek Minor, lead researcher and a Harrison Distinguished Teaching Professor in the Medical School, explained that by studying and refining the structure of dexamethasone as well as serum albumin, the team of scientists discovered that the steroids transport may influence its effectiveness in patients.

We started to look at this structure [of dexamethasone] and because we were working on albumin, Minor said. We found that dexamethasone binds to the same side as some drugs If the person is taking some other drug, there is a competition for the active site. If his active site is already occupied, [dexamethasone and albumin] cannot bind together.

Minor and the team of researchers demonstrated for the first time how dexamethasone binds with serum albumin for transport. Their new research indicates that other drugs and the hormone testosterone may compete with dexamethasone for the limited sites on serum albumin, resulting in drug displacement. In drug displacement, a drug administered at a high concentration can displace another drug, like dexamethasone, at the binding site, limiting its potential effectiveness. The scientists found that the testosterone molecule binds to albumin in the same way that dexamethasone does, further suggesting a competition between the two.

Those with diabetes have been found to have more severe symptoms of and complications with COVID-19. Diabetic patients often have high blood sugar levels which may modify serum albumin, affecting the binding site of dexamethasone.

In analyzing data from 373 patients at a hospital in Wuhan, China, the researchers also discovered that patients with high blood sugar levels as well as patients with lower than normal levels of albumin made up the majority of those who died from COVID-19.

Apparently if you have a higher level of albumin, you can survive, Minor said. The level of albumin in the case of women is higher than the case of men, and this explains why women have a higher chance to survive.

Further research is still needed to understand how best to treat COVID-19 patients affected by diabetes and high risk factors, like low levels of albumin. The researchers propose that clinical studies investigate alternative ways of administering dexamethasone to these patients.

[Studies] could try to administer small doses of dexamethasone over a longer period of time, Brzezinski said. This way if youre not transporting that much dexamethasone, then [there] wont be that much free dexamethasone in the body, so it wont have negative effects.

Increasing the dosage of dexamethasone for diabetic and at-risk patients may seem like an easy solution to override competing drugs, but too much dexamethasone over a long period of time can be harmful to the body.

The other idea is that you can administer dexamethasone not through injection but through inhalers, Brzezinski said. And this way you dont have albumin, you have a different way of transport and youre avoiding the problem altogether.

Here is the original post:
Dexamethasone study provides insight into COVID-19 treatment for patients with diabetes, other risk factors - University of Virginia The Cavalier...

Read More...

Could You Be Prediabetic or Diabetic and Not Know It? The Signs – The Beet

December 16th, 2020 9:54 pm

With 88 millionAmericans or approximately 1 in every 3 adults,suffering from prediabetes in this country (and 34 million Americans, or 1 in 10, with full-blown type 2 diabetes), many people are walking around with a ticking time bomb in their bodies, and don't even know they have the condition.

Prediabetes is when your blood sugar level is higher than it should be for optimal health, butnot high enough for your doctor to diagnose the disease.It's also known asimpaired fasting glucose or glucose intolerance. The scary part is, 90 percent of those with prediabetes dont know that they have it.

We have all heard that excessive thirst or urinating more often than normal is a sign that you could have diabetes, but what are the telltale signals that you may be pre-diabetic? Why does it matter? The sooner you find out the better, for your health and to know that changing your lifestyle can alter the course of the disease and head it off at the pass.

Prediabetes, unlike diabetes, is an asymptomatic condition. The soonersomeone finds out that they are prediabetic the better, experts say, since it's possible to make lifestyle changes that can reverse your health and get you back onto a healthy path, with simple switches like eating more plant-based foods, losing a small amount of body weight, and being more active, such as walking 30 minutes a day, five days a week.

"Prevention is the best medicine!If you are given a prediabetes or diabetes diagnosisdo not despair," since you can make simple lifestyle changes (exercise, diet, and losing a small amount of weight) to reverse course on the disease, saysKellie Antinori-Lent, MSN, RN, andPresident of the Association of Diabetes Care and Education Specialists (ADCES) and diabetes clinical nurse specialist at the University of Pittsburgh Medical Center, Shadyside Hospital in Pittsburgh.

"If someone is at risk for developing prediabetes or diabetes, they should schedule an appointment with their doctor to discuss their concerns and questions. The best first place to begin is with a visit to your providerwhether in person or virtualand dont delay," says Antinori-Lent. Prevention is the best medicine!If you are given a prediabetes or diabetes diagnosisdo not despair!" There are simple things you can do to dial back the condition such as exercise 30 minutes a day, lose 7 to 10 percent of your body weight, and eat a mostly whole-food, plant-based diet, high in fiber and low in added sugars and chemicals.

How do you know if you have diabetes or prediabetes? We asked Antinori-Lent,who makes it her life's work to educate people about the changes they can make to ensure their future health, and here is what she had to tell us:

Kellie: That is a really good question, however, prediabetes does not have symptoms. There is a physical sign of insulin resistance, which is associated with prediabetes. This sign is darkened skin in areas such as the neck, under the arms, and elbows. Some people mistake it as an area of skin they didn't wash wellbut you cannot wash acanthosis nigricans (the name of the dark skin areas). Instead, there are risk factors. These include:

Keep in mind that prediabetes can develop into type 2 diabetes if left untreated. People can prevent this from happening by evaluating their lifestyle habits, including changing their diet, increasing their exercise and activity levels and seeing their doctor regularly, and working withhim or her to prevent the progression.

Originally posted here:
Could You Be Prediabetic or Diabetic and Not Know It? The Signs - The Beet

Read More...

The Link Between Type 2 Diabetes and Heart Disease – WebMD

December 16th, 2020 9:54 pm

Type 2 diabetes raises your odds of developing heart disease, as does prediabetes. If youve been diagnosed with either, start paying attention to your heart health now.

You dont need to have diabetes before you get heart disease, says endocrinologist Matthew Freeby, MD, an assistant clinical professor of medicine and director of the Gonda Diabetes Center at David Geffen UCLA School of Medicine. We know theres a higher risk of heart disease in people with prediabetes.

Prediabetes occurs when your body can no longer keep your blood sugar level within a normal range. Unchecked, over time it may rise high enough to warrant a diagnosis of diabetes. Elevated blood sugar, in both prediabetes and diabetes, can harm your blood vessels and the nerves that keep your heart and blood vessels functioning properly. Over time, this can cause heart disease.

But, says Freeby, thats only part of the picture. Most people diagnosed with prediabetes or diabetes also have other conditions that threaten the heart: high blood pressure, high cholesterol, and obesity. Such health problems, collectively known as metabolic syndrome, boost the likelihood of blood clots as well as damage to the arteries in your heart.

Managing the risk of heart attack and stroke is less about managing diabetes than it is about reducing the risk factors that go along with diabetes, says Freeby.

Both diabetes and heart disease may lead to heart failure, which may weaken your heart so it cant function properly. Its one of the earliest, most serious, and most common heart problems in diabetes. Diabetes often worsens heart failure, while heart failure can complicate your diabetes treatment.

We only have so many tools at hand for lowering your blood sugars, and some of these are medications that should not be used if you have heart failure, says Freeby.

Fortunately, you have your own tools to protect your heart. Reduce your risks of heart disease -- and diabetes if you have prediabetes -- by modifying your lifestyle in ways that will improve your overall health. It may not be easy, but you dont have to make dramatic changes overnight. Some areas to focus on:

Slim down. Excess weight burdens your heart. To shed pounds, start with small, attainable goals. You dont need to set a lofty goal for weight loss says Freeby. That 5 or 10 pounds you do lose will have a big, positive effect.

Get moving. Exercise will help keep your heart healthy. Dont aim to do too much too soon or youll risk injury. Focus, instead, on simply getting started. Find an activity that you like to do that wont cause you pain and that will keep you coming back day after day, Freeby says.

Eat right. Go easy on your favorite foods, especially processed foods and simple sugar treats. Discuss your daily meals with a dietitian and understand you arent alone. Every person is different, says Freeby, but we all struggle to make dietary modifications.

Get screened. Freeby recommends regular screening for diabetes, as early diagnosis can modify the course of diabetes-related complications.

Care for yourself. To help manage diabetes risk or the disease if you have it, try relaxation techniques to reduce stress, get a good night's sleep, and maintain an active social life, says Freeby.

Find more articles, browse back issues, and read the current issue of WebMD Magazine .

SOURCES:

Matthew Freeby, MD, endocrinologist, assistant clinical professor of medicine, and director of the Gonda Diabetes Center, Los Angeles.

Cleveland Clinic: How to Protect Your Heart When You Have Prediabetes.

National Institute of Diabetes and Digestive and Kidney Diseases: Diabetes, Heart Disease, and Stroke.

National Heart, Lung, and Blood Institute: Heart Failure.

Pagination

View post:
The Link Between Type 2 Diabetes and Heart Disease - WebMD

Read More...

Dogs and owners may share resemblance in diabetes risk – The Guardian

December 16th, 2020 9:54 pm

Its said that dogs resemble their owners, but the similarities may also extend to their risk of diabetes, research suggests. The same cannot be said of cat owners and their companions, however.

Previous studies had hinted that overweight owners tend to have porkier pets, possibly because of shared health behaviours such as overeating or not taking regular exercise. To investigate whether this extended to a shared risk of type 2 diabetes, Beatrice Kennedy, of Uppsala University in Sweden, and colleagues turned to insurance data from Swedens largest pet insurance company, using owners 10-digit national identification numbers to pull their anonymised health records.

Comparing data from 208,980 owner/dog and 123,566 owner/cat pairs, they discovered that owning a dog with diabetes was associated with a 38% increased risk of having type 2 diabetes compared with owning a healthy hound. Personal and socioeconomic circumstances of the dog owners could not explain this link. No shared risk of diabetes was found between cat owners and their pets, however. The research was published in the British Medical Journal.

As in humans, diet and obesity can influence the risk of type 2 diabetes in both types of animals. Also like humans, the prevalence of diabetes in dogs and cats appears to be on the increase.

Given the previous research on the shared risk of [being overweight] between dog owners and their animals, we believe that shared dietary habits and also physical activity levels might be involved, said Kennedy.

The absence of a shared risk between cats and their owners may also point towards physical activity being an important factor. Cats usually prefer more independence from their owners when it comes to their movements, Kennedy said.

Shared environmental exposures to things such as pollutants or chemicals between dogs and their owners could be another avenue worth exploring, she added. Because this was an observational study, the researchers could not confirm the underlying cause of the association.

However, given that it exists, a diagnosis of diabetes in any household member including canine companions could signal a need to reassess the health behaviours of the whole family unit. The diabetes of the dog could be a marker of something important going on, Kennedy said. We know that there are quite strong emotional bonds between dog owners and their dogs. Perhaps that bond extends to other health behaviours and risks.

Go here to read the rest:
Dogs and owners may share resemblance in diabetes risk - The Guardian

Read More...

CDC: People with diabetes may be at risk for a more severe case of COVID-19 – Yahoo News

December 16th, 2020 9:54 pm

The Week

While looking at Florida's COVID-19 death tally, the South Florida Sun Sentinel found a pattern suggesting the state "manipulated a backlog of unrecorded fatalities" so the daily death numbers were artificially low ahead of the November presidential election, the newspaper reported Tuesday.There is a lag between the date a person dies of COVID-19 in Florida and the date the state reports the death as part of the public count. The Sun Sentinel found that with just a few exceptions, starting on Oct. 24, Florida stopped including deaths that occurred more than a month earlier in daily counts. It wasn't until Nov. 17, two weeks after the election, that these backlogged deaths were consistently included in the daily tally.These deaths have "long formed a significant part of the daily totals in Florida" because it can take some time for death reports to make it from a doctor's office to the health department, the Sun Sentinel reports. For example, from Sept. 23 to Oct. 20, the state included in its daily tallies 1,128 deaths that took place at least one month earlier. This accounted for 44 percent of the deaths that were announced over those four weeks.On Oct. 21, the state said it would start conducting additional reviews of each suspected COVID-19 death in Florida before adding it to the official count. Florida Gov. Ron DeSantis (R), a supporter of President Trump, has a history of downplaying the coronavirus pandemic, and the Sun Sentinel reports he has also speculated that the death statistics in the state were inflated. The Sun Sentinel said it asked several state officials about the data patterns, including the spokesman for the Florida Department of Health, and no one would comment.Scott David Herr, a Florida computer scientist who tracks the state's daily COVID-19 data, told the Sun Sentinel "it's hard to know if there was a limitation around election time or random other things were happening. The Department of Health hasn't explained why lags have been inconsistent. When they keep changing whatever is going on behind the scenes, when the lags keep changing, that is where it gets confusing." Read more at the Sun Sentinel.More stories from theweek.com Joe Biden still doesn't get it Republicans' hedonic treadmill problem The plan to disinfect the White House before Biden moves in is a 'huge waste of time and effort,' experts say

See the article here:
CDC: People with diabetes may be at risk for a more severe case of COVID-19 - Yahoo News

Read More...

Learn ways to lower your risk of developing diabetes – The Oakland Press

December 16th, 2020 9:54 pm

The notorious Freshman 15 those extra pounds college students can pack on when they first live away from home has now morphed into the Quarantine 15 during the COVID-19 pandemic. Its not surprising, as many adults are stressed, have irregular schedules and limited access to gyms, but plenty of Facetime or Zoom meetings next to snack-filled cupboards.

Today, one in three U.S. adults has prediabetes. Of those, 84% do not know they are in this danger zone because there are no clear symptoms, according to the Centers for Disease Control and Prevention (CDC). This figure is more concerning now due to COVID-delayed check-ups when people are typically reminded by their doctor to eat healthy and exercise. Since weight gain and sedentary behaviors can increase the risk for prediabetes or even progression to Type 2 diabetes, developing healthy and sustainable habits is critical to prevention.

Prediabetes can develop when a persons body is not using insulin correctly or making enough to process glucose, also known as blood sugar, properly. Insulin is a hormone produced by the pancreas that helps the body turn blood sugar into energy. If a persons blood sugar is too high for extended periods, as seen with Type 2 diabetes, it can result in long-term damage to organs, as in heart and kidney disease, as well as limb and vision loss.

Prediabetes is a precursor to Type 2 diabetes, but it can be reversed or prevented by focusing on healthier lifestyle habits. Risk factors include age, family history, obesity, poor diet and consistent inactivity. While some of these factors are uncontrollable, incorporating healthy food choices and physical activity into each day can significantly reduce the risk for prediabetes.

The CDC recommends adults get at least 150 minutes of aerobic activity each week that's less than 22 minutes per day if practiced every day. Try these tips to get moving:

Take a walk around the block every couple of hours.

Set phone reminders for daily exercise.

Turn a conference call into a walking meeting, if possible.

Use laundry detergent containers, canned goods or other household items as hand weights for exercises such as squats or lunges.

Practicemindful eating, keeping aware of yourportions. Its important to understand that it takes about 20 minutes for the brain to register signals from the stomach that its full. This often results in overeating and excessive calorie intake. Here are some ways to keep the grazing under control:

Structure snacks and meals throughout the day to prevent hunger binges.

Track food intake and read labels to monitor calories and better understand the nutritional value of items.

Dont eat out of bags portion out nuts, pretzels and crackers.

Keep healthy snacks on hand such asraw nuts, cut fruits and vegetables, hummus or a homemade Greek yogurt dip. Dipping fresh vegetables like celery or carrot sticks in such dips will provide protein along with a satisfying crunch, fiber and minerals for a lower-calorie snack.

Shanthi Appel is a registered dietitian and health and wellness spokesperson for Blue Cross Blue Shield of Michigan. For more tips on lowering your risks of diabetes, visitahealthiermichigan.org.

View original post here:
Learn ways to lower your risk of developing diabetes - The Oakland Press

Read More...

Water is a powerful weapon against obesity and diabetes Earth.com – Earth.com

December 16th, 2020 9:54 pm

In a new study, experts describe how drinking water can protect against metabolic syndrome. The researchers discovered that while fructose stimulates the release of vasopressin, a hormone linked to obesity and diabetes, water can suppress the hormone and alleviate these conditions in mice.

Study lead author Dr. Miguel A. Lanaspa is an associate professor at the University of Colorado School of Medicine who specializes in renal disease and hypertension.

The clinical significance of this work is that it may encourage studies to evaluate whether simple increases in water intake may effectively mitigate obesity and metabolic syndrome, said Dr. Lanaspa.

The researchers set out to investigate why vasopressin, which maintains the bodys water levels, is elevated in people with obesity and diabetes.

In an experiment based on a mouse model, the experts fed mice sugar water specifically fructose and noticed that it stimulated the brain to make vasopressin. As a result, the vasopressin stored the water as fat, causing dehydration that triggered obesity. When the mice were treated with non-sugary water, their obesity was reduced.

According to Dr. Lanaspa, this is the first time scientists have shown how vasopressin acts on dietary sugar to cause obesity and diabetes.

We found that it does this by working through a particular vasopressin receptor known as V1b. This receptor has been known for a while but no one has really understood its function. We found that mice lacking V1b were completely protected from the effects of sugar. We also show that the administration of water can suppress vasopressin and both prevent and treat obesity.

The researchers also discovered that dehydration can stimulate the formation of fat. This explains why vasopressin is so high in desert mammals as they do not have easy access to water, noted study co-author Dr. Richard Johnson. So vasopressin conserves water by storing it as fat.

The findings support previous observations that obese patients often exhibit signs of dehydration. The research also explains why high salt diets tend to cause obesity and diabetes.

The study revealed that water therapy effectively protects against metabolic syndrome, which is a collection of coexisting conditions including high blood pressure, high blood sugar, and high triglyceride levels. Metabolic syndrome greatly increases the risk of heart disease, stroke, and type 2 diabetes.

The best way to block vasopressin is to drink water, said Dr. Lanaspa. This is hopeful because it means we may have a cheap, easy way of improving our lives and treating metabolic syndrome.

Sugar drives metabolic syndrome in part by the activation of vasopressin. Vasopressin drives fat production likely as a mechanism for storing metabolic water, concluded said Dr. Johnson. The potential roles of hydration and salt reduction in the treatment of obesity and metabolic syndrome should be considered.

The study is published in the journal JCI Insight.

By Chrissy Sexton, Earth.com Staff Writer

View original post here:
Water is a powerful weapon against obesity and diabetes Earth.com - Earth.com

Read More...

Page 250«..1020..249250251252..260270..»


2025 © StemCell Therapy is proudly powered by WordPress
Entries (RSS) Comments (RSS) | Violinesth by Patrick