StemCell Therapy

REHOVOT, Israel, Feb. 8, 2021 /PRNewswire/ -- CollPlant Biotechnologies (NASDAQ: CLGN) today announced it has entered into a worldwide exclusive development and commercialization agreement for dermal and soft tissue filler products with Allergan Aesthetics, an AbbVie company.

CollPlanthasgrantedAllergan Aesthetics worldwide exclusivity to use itsplant-derived recombinant human collagen (rhCollagen)in combination with Allergan Aesthetics' proprietary technologies, for the production and commercialization of dermal and soft tissue fillers. In addition, Allergan Aesthetics has the right of first negotiation for CollPlant's technology in two future additional products.

CollPlant will receive an upfront payment of $14 million and is entitled to receive up to an additional $89 million in milestone payments. In addition, CollPlant is eligible to receive royalty payments and a fee for the manufacture and supply of rhCollagen to Allergan Aesthetics.

Yehiel Tal, Chief Executive Officer of CollPlant, stated, "We are very pleased to formalize this collaboration with Allergan Aesthetics, the worldwide leader in dermal and soft tissue fillers. We believe that combining technologies from Allergan Aesthetics and CollPlant will create a paradigm shift in the medical aesthetics field. CollPlant's rhCollagen is non-immunogenic and non-allergenic, and offers better tissue regeneration performance over animal-derived collagen which is currently used in medical aesthetics. This agreement further validates CollPlant's technology as the gold standard collagen for regenerative and aesthetic medicine. We look forward to a highly productive partnership."

Roger J. Pomerantz, MD, FACP, Chairman of the Board of Directors at CollPlant, said, "Our company is extremely excited to expand our work in medical aesthetics towards commercialization in the dermal filler market, which is projected to reach $10 billion by 2026. This collaboration is a major step forward, firmly placing CollPlant at the next level in applying our regenerative medicine technology to tackle new areas in biomedicine."

About CollPlant

CollPlant is a regenerative and aesthetic medicine company focused on 3D bioprinting of tissues and organs, and medical aesthetics. CollPlant's products are based on its rhCollagen (recombinant human collagen) that is produced with CollPlant's proprietary plant based genetic engineering technology.

CollPlant's products address indications for the diverse fields of tissue repair, aesthetics and organ manufacturing, and are ushering in a new era in regenerative and aesthetic medicine.

CollPlant's flagship rhCollagen BioInk product line is ideal for 3D bioprinting of tissues and organs. In 2018, CollPlant entered into a licensing agreement with United Therapeutics, whereby United Therapeutics is using CollPlant's BioInks in the manufacture of 3D bioprinted lungs for transplant in humans.

For more information, visithttp://www.collplant.com.

Contacts at CollPlant:

Eran RotemDeputy CEO & Chief Financial OfficerTel: + 972-73-2325600/631Email:[emailprotected]

Safe Harbor for Forward-Looking Statements

This press release may include forward-looking statements. Forward-looking statements may include, but are not limited to, statements relating to CollPlant's objectives, plans and strategies, as well as statements, other than historical facts, that address activities, events or developments that CollPlant intends, expects, projects, believes or anticipates will or may occur in the future. These statements are often characterized by terminology such as "believes," "hopes," "may," "anticipates," "should," "intends," "plans," "will," "expects," "estimates," "projects," "positioned," "strategy" and similar expressions and are based on assumptions and assessments made in light of management's experience and perception of historical trends, current conditions, expected future developments and other factors believed to be appropriate. Forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statements. Many factors could cause CollPlant's actual activities or results to differ materially from the activities and results anticipated in forward-looking statements, including, but not limited to, the following: CollPlant's history of significant losses and its need to raise additional capital and its inability to obtain additional capital on acceptable terms, or at all; CollPlant's expectations regarding the timing and cost of commencing clinical trials with respect to products which are based on CollPlant's rhCollagen; CollPlant's ability to obtain favorable pre-clinical and clinical trial results; regulatory action with respect to the products, including but not limited to acceptance of an application for marketing authorization, review and approval of such application, and, if approved, the scope of the approved indication and labeling; commercial success and market acceptance of the products; CollPlant's ability to establish sales and marketing capabilities or enter into agreements with third parties and its reliance on third-party distributors and resellers; CollPlant's ability to establish and maintain strategic partnerships and other corporate collaborations; CollPlant's reliance on third parties to conduct some aspects of its product manufacturing; the scope of protection CollPlant is able to establish and maintain for intellectual property rights and the companies' ability to operate their business without infringing the intellectual property rights of others; the overall global economic environment; the impact of competition and new technologies; general market, political, and economic conditions in the countries in which the companies operate; projected capital expenditures and liquidity; changes in the companies' strategy; and litigation and regulatory proceedings. More detailed information about the risks and uncertainties affecting CollPlant is contained under the heading "Risk Factors" included in CollPlant's most recent annual report on Form 20-F, respectively, filed with the SEC, and in other filings that CollPlant has made and may make with the SEC in the future. The forward-looking statements contained in this press release are made as of the date of this press release and reflect CollPlant's current views with respect to future events, and neither company undertakes, and each company specifically disclaims, any obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

SOURCE CollPlant

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CollPlant Announces Development and Global Commercialization Agreement with Allergan Aesthetics, an AbbVie company, for rhCollagen in Dermal and Soft...

Researchers from the Antimicrobial Resistance (AMR) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MITs research enterprise in Singapore, and Nanyang Technological University (NTU) have developed a tool using CRISPRi technology that can help understand and prevent biofilm development, drug resistance, and other physiological behaviors of bacteria such as Enterococcus faecalis.

E. faecalis, which is found in the human gut, is one of the most prevalent causes of hospital-associated infections and can lead to a variety of multidrug-resistant, life-threatening infections including bacteremia (bloodstream infection), endocarditis (infection of the heart), catheter-associated urinary tract infection, and wound infections.

However, current methods for understanding and preventing E. faecalis biofilm formation and development are labor-intensive and time-consuming. The SMART AMR research team designed an easily modifiable genetic technique that allows rapid and efficient silencing of bacteria genes to prevent infections.

In a paper published in the journal mBio, the researchers explain the scalable dual-vector nisin-inducible CRISPRi system, which can identify genes that allow bacteria like E. faecalis to form biofilms, cause infections, acquire antibiotic resistance, and evade the host immune system. The team combined CRISPRi technology with rapid DNA assembly under controllable promoters, which enables rapid silencing of single or multiple genes, to investigate nearly any aspect of enterococcal biology.

Infections caused by E. faecalis are usually antibiotic-tolerant and more difficult to treat, rendering them a significant public health threat, says Irina Afonina, postdoc at SMART AMR and lead author of the paper. Identifying the genes that are involved in these bacterial processes can help us discover new drug targets or propose antimicrobial strategies to effectively treat such infections and overcome antimicrobial resistance.

The team believes their new tool will be valuable in rapid and efficient investigation of a wide range of aspects of enterococcal biology and pathogenesis, host-bacterium interactions, and interspecies communication. The method can be scaled up to simultaneously silence multiple bacterial genes or perform full-genome studies.

Bacterial biofilms are clusters of bacteria that are enclosed in a protective, self-produced matrix, says SMART AMR principal investigator and NTU Associate Professor Kimberly Kline, also the corresponding author of the paper. The system we designed enables us to easily interrogate various stages during the biofilm developmental cycle of E. faecalis. By selectively silencing certain genes in preformed, mature biofilms, we can erode the biofilm and force it to disperse.

The scalable CRISPRi system uses high-throughput screens that can allow for rapid identification of gene combinations to be simultaneously targeted for novel and efficient antimicrobial combinatorial therapies.

The idea behind SMARTs inducible CRISPRi system was conceived by Kline and SMART AMR principal investigator Professor Timothy Lu, an associate professor in the MIT departments of Electrical Engineering and Computer Science and Biological Engineering, while Afonina developed and delivered the genetic tool.

The research is carried out by SMART and supported by the National Research Foundation (NRF) Singapore under its Campus for Research Excellence And Technological Enterprise (CREATE) program.

SMART was established by MIT in partnership with the NRF Singapore in 2007. SMART is the first entity in CREATE developed by NRF. SMART serves as an intellectual and innovation hub for research interactions between MIT and Singapore, undertaking cutting-edge research projects in areas of interest to both Singapore and MIT. SMART currently comprises an Innovation Center and five IRGs: AMR, Critical Analytics for Manufacturing Personalized-Medicine, Disruptive and Sustainable Technologies for Agricultural Precision, Future Urban Mobility, and Low Energy Electronic Systems.

The AMR IRG is a translational research and entrepreneurship program that tackles the growing threat of antimicrobial resistance. By leveraging talent and convergent technologies across Singapore and MIT, they tackle AMR head-on by developing multiple innovative and disruptive approaches to identify, respond to, and treat drug-resistant microbial infections. Through strong scientific and clinical collaborations, they provide transformative, holistic solutions for Singapore and the world.

Originally posted here:
A new tool to investigate bacteria behind hospital infections - MIT News

DALLAS--(BUSINESS WIRE)--Taysha Gene Therapies, Inc. (Nasdaq: TSHA), a patient-centric, clinical-stage gene therapy company focused on developing and commercializing AAV-based gene therapies for the treatment of monogenic diseases of the central nervous system (CNS) in both rare and large patient populations, today announced multi-year collaborations with Cleveland Clinic and UT Southwestern Gene Therapy Program (UTSW) to advance next-generation mini-gene payloads for AAV gene therapies for the treatment of genetic epilepsies and additional CNS disorders. Taysha will have an exclusive option on new payloads, constructs and intellectual property associated with, and arising from, the research conducted under this agreement.

A team of researchers from Cleveland Clinic Lerner Research Institute will create mini-gene payloads designed to address some of the long-standing limitations in AAV gene therapy. UTSW will create and evaluate vector constructs in in vivo and in vitro efficacy models of genetic epilepsies and additional CNS disorders.

By pushing the boundaries of AAV vector engineering, we may be able to overcome some of the challenges inherent with gene therapy and potentially expand the range of treatable genetic CNS diseases with gene therapies. We appreciate the support from Taysha and UTSW in this work, said Dennis Lal, Ph.D., Assistant Staff at Cleveland Clinic Genomic Medicine Institute and Neurological Institute. We believe that our proprietary approach to overcoming current limitations of packaging capacity and our access to data on thousands of protein structures associated with a whole host of monogenic CNS disorders has the potential to enable a deep pipeline of functioning mini-genes.

Cleveland Clinic and UTSW are two of the worlds preeminent leaders in gene therapy innovation, and this collaboration is designed to leverage our capabilities and synergies with these institutions to pioneer novel approaches to address vector capacity, which is a common limitation when treating genetic disorders associated with large proteins, said Suyash Prasad, MBBS, M.SC., MRCP, MRCPCH, FFPM, Chief Medical Officer and Head of Research and Development of Taysha. We look forward to a productive collaboration with the goal of developing treatments with promising benefits to patients with debilitating genetic epilepsies.

About Taysha Gene Therapies

Taysha Gene Therapies (Nasdaq: TSHA) is on a mission to eradicate monogenic CNS disease. With a singular focus on developing curative medicines, we aim to rapidly translate our treatments from bench to bedside. We have combined our teams proven experience in gene therapy drug development and commercialization with the world-class UT Southwestern Gene Therapy Program to build an extensive, AAV gene therapy pipeline focused on both rare and large-market indications. Together, we leverage our fully integrated platforman engine for potential new cureswith a goal of dramatically improving patients lives. More information is available at http://www.tayshagtx.com.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as anticipates, believes, expects, intends, projects, and future or similar expressions are intended to identify forward-looking statements. Forward-looking statements include statements concerning or implying the potential of our collaboration with the Cleveland Clinic and UTSW, the potential of our product candidates to positively impact quality of life and alter the course of disease in the patients we seek to treat, our research, development and regulatory plans for our product candidates, the potential benefits of rare pediatric disease designation and orphan drug designation to our product candidates, the potential for these product candidates to receive regulatory approval from the FDA or equivalent foreign regulatory agencies, and whether, if approved, these product candidates will be successfully distributed and marketed. Forward-looking statements are based on managements current expectations and are subject to various risks and uncertainties that could cause actual results to differ materially and adversely from those expressed or implied by such forward-looking statements. Accordingly, these forward-looking statements do not constitute guarantees of future performance, and you are cautioned not to place undue reliance on these forward-looking statements. Risks regarding our business are described in detail in our Securities and Exchange Commission (SEC) filings, including in our Quarterly Report on Form 10-Q for the quarter ended September 30, 2020, which is available on the SECs website at http://www.sec.gov. Additional information will be made available in other filings that we make from time to time with the SEC. Such risks may be amplified by the impacts of the COVID-19 pandemic. These forward-looking statements speak only as of the date hereof, and we disclaim any obligation to update these statements except as may be required by law.

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Taysha Gene Therapies Announces Collaborations to Advance Next-Generation Mini-Gene Payloads for AAV Gene Therapies for the Treatment of Genetic...

Dublin, Feb. 08, 2021 (GLOBE NEWSWIRE) -- The "Global CRISPR Gene Editing Market: Focus on Products, Applications, End Users, Country Data (16 Countries), and Competitive Landscape - Analysis and Forecast, 2020-2030" report has been added to ResearchAndMarkets.com's offering.

The global CRISPR gene editing market was valued at $846.2 million in 2019 and is expected to reach $10,825.1 million by 2030, registering a CAGR of 26.86% during the forecast.

The development of genome engineering with potential applications proved to reflect a remarkable impact on the future of the healthcare and life science industry. The high efficiency of the CRISPR-Cas9 system has been demonstrated in various studies for genome editing, which resulted in significant investments within the field of genome engineering. However, there are several limitations, which need consideration before clinical applications. Further, many researchers are working on the limitations of CRISPR gene editing technology for better results. The potential of CRISPR gene editing to alter the human genome and modify the disease conditions is incredible but exists with ethical and social concerns.

The growth is attributed to the increasing demand in the food industry for better products with improved quality and nutrient enrichment and the pharmaceutical industry for targeted treatment for various diseases. Further, the continued significant investments by healthcare companies to meet the industry demand and growing prominence for the gene therapy procedures with less turnaround time are the prominent factors propelling the growth of the global CRISPR gene editing market.

Research organizations, pharmaceutical and biotechnology industries, and institutes are looking for more efficient genome editing technologies to increase the specificity and cost-effectiveness, also to reduce turnaround time and human errors. Further, the evolution of genome editing technologies has enabled wide range of applications in various fields, such as industrial biotech and agricultural research. These advanced methods are simple, super-efficient, cost-effective, provide multiplexing, and high throughput capabilities. The increase in the geriatric population and increasing number of cancer cases, and genetic disorders across the globe are expected to translate into significantly higher demand for CRISPR gene editing market.

Furthermore, the companies are investing huge amounts in the research and development of CRISPR gene editing products, and gene therapies. The clinical trial landscape of various genetic and chronic diseases has been on the rise in recent years, and this will fuel the CRISPR gene editing market in the future.

Within the research report, the market is segmented based on product type, application, end-user, and region. Each of these segments covers the snapshot of the market over the projected years, the inclination of the market revenue, underlying patterns, and trends by using analytics on the primary and secondary data obtained.

Key Companies Profiled

Abcam, Inc., Applied StemCell, Inc., Agilent Technologies, Inc., Cellecta, Inc., CRISPR Therapeutics AG, Thermo Fisher Scientific, Inc., GeneCopoeia, Inc., GeneScript Biotech Corporation, Horizon Discovery Group PLC, Integrated DNA Technologies, Inc., Merck KGaA, New England Biolabs, Inc., Origene Technologies, Inc., Rockland Immunochemicals, Inc., Synthego Corporation, System Biosciences LLC, ToolGen, Inc., Takara Bio

Key Questions Answered in this Report:

Key Topics Covered:

1 Technology Definition

2 Research Scope

3 Research Methodology

4 Market Overview4.1 Introduction4.2 CRISPR Gene Editing Market Approach4.3 Milestones in CRISPR Gene Editing4.4 CRISPR Gene Editing: Delivery Systems4.5 CRISPR Technology: A Potential Tool for Gene Editing4.6 CRISPR Gene Editing Current Scenario4.7 CRISPR Gene Editing Market: Future Potential Application Areas

5 Global CRISPR Gene Editing Market, $Million, 2020-20305.1 Pipeline Analysis5.2 CRISPR Gene Editing Market and Growth Potential, 2020-20305.3 Impact of COVID-19 on CRISPR Gene Editing Market5.3.1 Impact of COVID-19 on Global CRISPR Gene Editing Market Growth Rate5.3.1. Impact on CRISPR Gene Editing Companies5.3.2 Clinical Trial Disruptions and Resumptions5.3.3 Application of CRISPR Gene Editing in COVID-19

6 Market Dynamics6.1 Impact Analysis6.2 Market Drivers6.2.1 Prevalence of Genetic Disorders and Use of Genome Editing6.2.2 Government and Private Funding6.2.3 Technology Advancement in CRISPR Gene Editing6.3 Market Restraints6.3.1 CRISPR Gene Editing: Off Target Effects and Delivery6.3.2 Ethical Concerns and Implications With Respect to Human Genome Editing6.4 Market Opportunities6.4.1 Expanding Gene and Cell Therapy Area6.4.2 CRISPR Gene Editing Scope in Agriculture

7 Industry Insights7.1 Introduction7.2 Funding Scenario7.3 Regulatory Scenario of CRISPR Gene Editing Market7.4 Pricing of CRISPR Gene Editing7.5 Reimbursement of CRISPR Gene Editing7.5.1 CRISPR Gene Editing: Insurance Coverage in the U.S.

8 CRISPR Gene Editing Patent Landscape8.1 Overview8.2 CRISPR Gene Editing Market Patent Landscape: By Application8.3 CRISPR Gene Editing Market Patent Landscape: By Region8.4 CRISPR Gene Editing Market Patent Landscape: By Year

9 Global CRISPR Gene Editing Market (by Product Type), $Million9.1 Overview9.2 CRISPR Products9.2.1 Kits and Enzymes9.2.1.1 Vector-Based Cas99.2.1.2 DNA-Free Cas99.2.2 Libraries9.2.3 Design Tools9.2.4 Antibodies9.2.5 Other Products9.3 CRISPR Services9.3.1 gRNA Design and Vector Construction9.3.2 Cell Line and Engineering9.3.3 Screening Services9.3.4 Other Services

10 CRISPR Gene Editing Market (by Application), $Million10.1 Overview10.2 Agriculture10.3 Biomedical10.3.1 Gene Therapy10.3.2 Drug Discovery10.3.3 Diagnostics10.4 Industrial10.5 Other Applications

11 Global CRISPR Gene Editing Market (by End User)11.1 Academic Institutions and Research Centers11.2 Biotechnology Companies11.3 Contract Research Organizations (CROs)11.4 Pharmaceutical and Biopharmaceutical Companies

12 Global CRISPR Gene Editing Market (by Region)12.1 Introduction12.2 North America12.3 Europe12.4 Asia-Pacific12.5 Latin America

13 Competitive Landscape13.1 Key Developments and Strategies13.1.1 Overview13.1.1.1 Regulatory and Legal Developments13.1.1.2 Synergistic Activities13.1.1.3 M&A Activities13.1.1.4 Funding Activities13.2 Market Share Analysis13.3 Growth Share Analysis

14 Company Profiles14.1 Overview14.2 Abcam, Inc.14.2.1 Company Overview14.2.2 Role of Abcam, Inc. in the Global CRISPR Gene Editing Market14.2.3 Financials14.2.4 SWOT Analysis14.3 Applied StemCell, Inc.14.3.1 Company Overview14.3.2 Role of Applied StemCell, Inc. in the Global CRISPR Gene Editing Market14.3.3 SWOT Analysis14.4 Agilent Technologies, Inc.14.4.1 Company Overview14.4.2 Role of Agilent Technologies, Inc. in the Global CRISPR Gene Editing Market14.4.3 Financials14.4.4 R&D Expenditure, 2017-201914.4.5 SWOT Analysis14.5 Cellecta, Inc.14.5.1 Company Overview14.5.2 Role of Cellecta, Inc. in the Global CRISPR Gene Editing Market14.5.3 SWOT Analysis14.6 CRISPR Therapeutics AG14.6.1 Company Overview14.6.2 Role of CRISPR Therapeutics AG in the Global CRISPR Gene Editing Market14.6.3 Financials14.6.4 R&D Expenditure, 2017-201914.6.5 SWOT Analysis14.7 Thermo Fisher Scientific, Inc. INC14.7.1 Company Overview14.7.2 Role of Thermo Fisher Scientific, Inc. in the Global CRISPR Gene Editing Market14.7.3 Financials14.7.4 R&D Expenditure, 2017-201914.7.5 SWOT Analysis14.8 GeneCopoeia, Inc.14.8.1 Company Overview14.8.2 Role of GeneCopoeia, Inc. in the Global CRISPR Gene Editing Market14.8.3 SWOT Analysis14.9 GeneScript Biotech Corporation14.9.1 Company Overview14.9.2 Role of GenScript Biotech in the Global CRISPR Gene Editing Market14.9.3 Financials14.9.4 SWOT Analysis14.1 Horizon Discovery Group PLC14.10.1 Company Overview14.10.2 Role of Horizon Discovery Group PLC in the Global CRISPR Gene Editing Market14.10.3 Financials14.10.4 SWOT Analysis14.11 Integrated DNA Technologies, Inc.14.11.1 Company Overview14.11.2 Role of Integrated DNA Technologies, Inc. in the Global CRISPR Gene Editing Market14.11.3 SWOT Analysis14.12 Merck KGaA14.12.1 Company Overview14.12.2 Role of Merck KGaA in the Global CRISPR Gene Editing Market14.12.3 Financials14.12.4 SWOT Analysis14.13 New England Biolabs, Inc.14.13.1 Company Overview14.13.2 Role of Integrated DNA Technologies, Inc. in the Global CRISPR Gene Editing Market14.13.3 SWOT Analysis14.14 Origene Technologies, Inc.14.14.1 Company Overview14.14.2 Role of Origene Technologies, Inc. in the Global CRISPR Gene Editing Market14.14.3 SWOT Analysis14.15 Rockland Immunochemicals, Inc.14.15.1 Company Overview14.15.2 Role of Rockland Immunochemicals, Inc. in the Global CRISPR Gene Editing Market14.15.3 SWOT Analysis14.16 Synthego Corporation14.16.1 Company Overview14.16.2 Role of Synthego Corporation in the Global CRISPR Gene Editing Market14.16.3 SWOT Analysis14.17 System Biosciences LLC14.17.1 Company Overview14.17.2 Role of System Biosciences LLC in the Global CRISPR Gene Editing Market14.17.3 SWOT Analysis14.18 ToolGen, Inc.14.18.1 Company Overview14.18.2 Role of ToolGen, Inc. in the Global CRISPR Gene Editing Market14.18.3 SWOT Analysis14.19 Takara Bio14.19.1 Company Overview14.19.2 Role of Takara Bio in the Global CRISPR Gene Editing Market14.19.3 Financials14.19.4 SWOT Analysis

For more information about this report visit https://www.researchandmarkets.com/r/c7om7t

Originally posted here:
Outlook on the CRISPR Gene Editing Global Market to 2030 - Analysis and Forecasts - GlobeNewswire

GAITHERSBURG, Md., Feb. 04, 2021 (GLOBE NEWSWIRE) -- Novavax, Inc. (Nasdaq: NVAX), a biotechnology company developing next-generation vaccines for serious infectious diseases, today announced the start of the rolling review process for authorization of NVX-CoV2373, its COVID-19 vaccine, by multiple regulatory agencies. The reviews will continue while the company completes its pivotal Phase 3 trials in the United Kingdom (U.K.) and United States (U.S.) and through initial authorization for emergency use granted under country-specific regulations.

The rolling review of our submission by regulatory authorities of non-clinical data and early clinical studies will help expedite the review process and bring us that much closer to delivering a safe and effective vaccine worldwide, said Gregory M. Glenn, MD, President of Research and Development, Novavax. We appreciate the agencies confidence in Novavax based on our early data and the collective sense of urgency to ensure speedier access to much-needed COVID-19 vaccination.

To date, Novavax has begun the rolling review process with several regulatory agencies worldwide, including the European Medicines Agency (EMA), U.S. Food and Drug Administration (FDA), U.K. Medicines and Healthcare products Regulatory Agency (MHRA), and Health Canada. As part of the rolling review, the company will continue to submit additional information, including clinical and manufacturing data.

Novavax recombinant protein-based vaccine candidate is currently in Phase 3 clinical development in both the U.K. and U.S. for the prevention of COVID-19. It was the first vaccine to demonstrate clinical efficacy against the original strain of COVID-19 and both of the rapidly emerging variants in the United Kingdom and South Africa.

About NVX-CoV2373

NVX-CoV2373 is a protein-based vaccine candidate engineered from the genetic sequence of SARS-CoV-2, the virus that causes COVID-19 disease. NVX-CoV2373 was created using Novavax recombinant nanoparticle technology to generate antigen derived from the coronavirus spike (S) protein and is adjuvanted with Novavax patented saponin-based Matrix-M to enhance the immune response and stimulate high levels of neutralizing antibodies. NVX-CoV2373 contains purified protein antigen and can neither replicate, nor can it cause COVID-19. In preclinical studies, NVX-CoV2373 induced antibodies that block binding of spike protein to cellular receptors and provided protection from infection and disease. It was generally well-tolerated and elicited robust antibody response numerically superior to that seen in human convalescent sera in Phase 1/2 clinical testing. NVX-CoV2373 is currently being evaluated in two pivotal Phase 3 trials: a trial in the U.K that demonstrated 89.3 percent overall efficacy and 95.6 percent against the original strain in a post-hoc analysis, and the PREVENT-19 trial in the U.S. and Mexico that began in December. It is also being tested in two ongoing Phase 2 studies that began in August: A Phase 2b trial in South Africa that demonstrated up to 60 percent efficacy against newly emerging escape variants, and a Phase 1/2 continuation in the U.S. and Australia.

About Matrix-MNovavax patented saponin-based Matrix-M adjuvant has demonstrated a potent and well-tolerated effect by stimulating the entry of antigen presenting cells into the injection site and enhancing antigen presentation in local lymph nodes, boosting immune response.

About NovavaxNovavax, Inc.(Nasdaq: NVAX) is a biotechnology company that promotes improved health globally through the discovery, development and commercialization of innovative vaccines to prevent serious infectious diseases. The companys proprietary recombinant technology platform combines the power and speed of genetic engineering to efficiently produce highly immunogenic nanoparticles designed to address urgent global health needs. Novavaxis conducting late-stage clinical trials for NVX-CoV2373, its vaccine candidate against SARS-CoV-2, the virus that causes COVID-19. NanoFlu, its quadrivalent influenza nanoparticle vaccine, met all primary objectives in its pivotal Phase 3 clinical trial in older adults and will be advanced for regulatory submission. Both vaccine candidates incorporate Novavax proprietary saponin-based Matrix-M adjuvant to enhance the immune response and stimulate high levels of neutralizing antibodies.

For more information, visit http://www.novavax.com and connect with us on Twitter and LinkedIn.

Novavax Forward Looking Statements

Statements herein relating to the future ofNovavaxand the ongoing development of its vaccine and adjuvant products are forward-looking statements.Novavaxcautions that these forward-looking statements are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those expressed or implied by such statements. These risks and uncertainties include those identified under the heading Risk Factors in the Novavax Annual Report on Form 10-K for the year endedDecember 31, 2019, and Quarterly Report on Form10-Qfor the period endedSeptember 30, 2020, as filed with theSecurities and Exchange Commission(SEC). We caution investors not to place considerable reliance on forward-looking statements contained in this press release. You are encouraged to read our filings with theSEC, available atsec.gov, for a discussion of these and other risks and uncertainties. The forward-looking statements in this press release speak only as of the date of this document, and we undertake no obligation to update or revise any of the statements. Our business is subject to substantial risks and uncertainties, including those referenced above. Investors, potential investors, and others should give careful consideration to these risks and uncertainties.

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Novavax Announces Start of Rolling Review by Multiple Regulatory Authorities for COVID-19 Vaccine Authorization - GlobeNewswire

A wide ranging Lab-on-a-chip market report offers the strategists, marketers and senior management with the critical information they need to assess the global market research services market. A good market research report makes it possible to develop strategies such as market segmentation that means identifying specific groups within a market and product differentiation which creates an identity for a product or service that separates it from those of the competitors. With Lab-on-a-chip market research report, it gets effortless to identify growth segments for investment as well as benchmark performance against key competitors.

Lab-on-a-chip market is expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market to account to USD 9.40 billion by 2027 and growing at a CAGR of 7.90% in the above-mentioned forecast period are majorly driven by the increasing application of lab on chip devices in the medical field.

Get Full PDF Sample Copy of Report: (Including Full TOC, List of Tables & Figures, Chart) @ https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-lab-on-a-chip-market&kb

The major players covered in the lab-on-a-chip market report are BD, Agilent Technologies, Danaher, Bio-Rad Laboratories, Inc, Hoffmann-La Roche Ltd, Perkin Elmer Corporation, IDEX, Thermo Fisher Scientific Inc, Cepheid, General Electric Company, Merck KGaA, and Healthcare among other domestic and global players.

Healthcare Infrastructure growth Installed base and New Technology Penetration

Lab-on-a-chip market also provides you with detailed market analysis for every country growth in healthcare expenditure for capital equipments, installed base of different kind of products for lab-on-a-chip market, impact of technology using life line curves and changes in healthcare regulatory scenarios and their impact on the lab-on-a-chip market. The data is available for historic period 2010 to 2018.

GlobalLab-On-A-Chip Market Scope and Market Size

Lab-on-a-chip market is segmented on the basis of product, application, technology and end-use. The growth amongst these segments will help you analyse meagre growth segments in the industries, and provide the users with valuable market overview and market insights to help them in making strategic decisions for identification of core market applications.

Enquire Here Get customization & check discount for report @: https://www.databridgemarketresearch.com/inquire-before-buying/?dbmr=global-lab-on-a-chip-market&kb

Lab-On-A-CHIP Market Country Level Analysis

Lab-on-a-chip market is analysed and market size insights and trends are provided by country, product, application, technology and end-use, as referenced above.

The countries covered in the lab-on-a-chip market report are U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America.

America is dominating the lab-on-a-chip market owing to increasing advances in molecular biology and genetic engineering techniques as well increasing prevalence of the diseases.

Table Of Content:

Part 01: Executive SummaryPart 02: Scope Of The ReportPart 03: Global Lab-On-A-Chip Market Landscape

Part 04: Global Lab-On-A-Chip Market Sizing

Part 05: Global Lab-On-A-Chip Market Segmentation By Product

Part 06: Five Forces Analysis

Part 07: Customer LandscapePart 08: Geographic Landscape

Part 09: Decision FrameworkPart 10: Drivers And Challenges

Part 11: Market Trends

Part 12: Vendor Landscape

Part 13: Vendor Analysis

And More..Get Detailed TOC At https://www.databridgemarketresearch.com/toc/?dbmr=global-lab-on-a-chip-market&kb

Opportunities in the market

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Global Lab-On-A-Chip Market Industry Perspective, Comprehensive Analysis, and Forecast 2027||Players-Perkin Elmer Corporation, IDEX, Thermo Fisher...

Freeline Presents Data on its Gaucher Disease and Fabry Disease AAV-Based Gene Therapies at the 17th Annual WORLDSymposium

Data demonstrate potential of FLT201 to deliver sustained levels of -glucocerebrosidase (GCase) variant 85, a proprietary engineered GCase that penetrates target tissues in Gaucher disease

First-in-human dose finding studies of FLT201 on-track for initiation in late 2021

London, February 8, 2021 Freeline Therapeutics Holdings plc (Nasdaq: FRLN) (the Company or Freeline), a clinical-stage biotechnology company developing transformative adeno-associated virus (AAV) vector-mediated gene therapies for patients suffering from inherited systemic debilitating diseases, today announced that it will deliver one oral and three e-poster presentations at the 17TH Annual WORLDSymposium taking place virtually from February 8 12, 2021, highlighting data from its gene therapy programs in Gaucher and Fabry diseases.

FLT201 data suggest that our gene therapy candidate for Gaucher disease is capable of delivering -glucocerebrosidase variant 85 (GCasevar85) to tissues not sufficiently addressed by standard-of-care enzyme replacement therapy (ERT), said Theresa Heggie, Chief Executive Officer of Freeline. In addition, we believe steady delivery of enzyme into target tissues to enable sustained clearance of pathologic substrate has the potential to offer significant improvements in clinical outcomes over existing standard of care.

We are excited by the transformational science that underlies the Freeline gene therapy platform, continued Ms. Heggie. We look forward to progressing both the Gaucher and Fabry programs through the clinic with the planned initiation of our first-in-human study in Gaucher disease and dose escalation in Part 1 of the ongoing MARVEL-1 Phase 1/2 study in Fabry disease later this year.

FLT201 represents our innovative solution for the treatment of Type 1 Gaucher disease. This candidate leverages the Companys proprietary high-potency adeno-associated virus capsid, known as AAVS3. In addition, our protein engineering group developed GCasevar85, a proprietary GCase variant which, compared to wild-type GCase, has a greater than 20-fold increase in half-life in lysosomal pH and a 6-10 fold increase in half-life in serum, resulting in a 20-fold increase in potency of the vector. FLT201 is a combination of the clinically validated, potent AAVS3 capsid combined with a liver-specific promoter that drives the expression of GCasevar85 said Romuald Corbau, Ph.D., Chief Scientific Officer of Freeline. These data demonstrate preclinical proof-of-concept for the potential of the program to provide functional cures in patients with the most common form of Gaucher disease, Type 1. Included in these data are demonstration of GCase expression, cellular uptake, tissue penetration, enzymatic activity, and clearance of disease causing substrate, glucosylsphingosine (lyso-Gb1). Considered in totality, these data suggest FLT201 may be able to deliver sustained GCase expression in difficult-to-reach tissues, such as bone marrow and lung, as evidenced by the substrate clearance.

Presentation highlights from the platform presentation and e-poster titled, FLT201: An AAV-Mediated Gene Therapy for Type 1 Gaucher Disease Designed to Target Difficult to Reach Tissues, presented by Dr. Corbau, include:

Presentation highlights from an e-poster titled Generation of -Glucocerebrosidase Variants with Increased Half-Life in Human Plasma for Liver Directed AAV Gene Therapy Aimed at the Treatment of Gaucher Disease Type 1, presented by Fabrizio Comper, Scientific Director, Freeline, include preclinical data on the generation and characterization of GCasevar85, which is part of the Companys development candidate for Gaucher disease, FLT201:

Presentation highlights from an e-poster titled Development of a GLA NAb Assay with a Fully-Human, Neutralizing IgG4 Positive Control to Characterize Antibody Response in Fabry Disease Patients, presented by Sujata Ravi, Scientist, Freeline, include data on the development of a NAb assay for the characterization and monitoring of NAbs in patients with Fabry disease who are receiving ERT or gene therapy:

The poster presentations will be available on theeventssection of the Freeline website beginning at 4:00pm EST on Monday, February 8, 2021. Registered WORLDSymposium attendees can access a recording of the oral presentation on Thursday, February 11, 2021.

About Gaucher Disease

Gaucher Disease is a genetic disorder in which a fatty substance called glucosylceramide accumulates in macrophages in certain organs due to the lack of functional GCase. The disorder is hereditary and presents in various subtypes. Freeline is currently focused on Gaucher disease Type 1, the most common type, which impacts the health of the spleen, liver, blood system and bones. The current standard of care is intravenous infusion of ERT every two weeks, which is a significant treatment burden on the patient. The aim of Freelines investigational gene therapy program is to deliver a one-time treatment of a long-lasting gene therapy that will provide a sustained, therapeutically relevant level of endogenous GCase, thus eliminating the need for ERT.

About FLT201 for Gaucher Disease

FLT201 is an investigational liver-directed AAV gene therapy in preclinical development for the treatment of Type 1 Gaucher disease. FLT201 contains a liver-specific promoter and a GBA1 sequence that expresses our novel, proprietary GCasevar85 variant, which has a 20-fold longer half-life at lysosomal pH conditions than wild-type GCase protein. Freelines high-transducing AAVS3 capsid advances our goal to address unmet needs for those affected by Gaucher disease by enabling sustained, endogenous production of GCase following one-time intravenous infusion. To our knowledge, Freeline is the only company to date that has announced a program for the development of an AAV gene therapy for the treatment of Type 1 Gaucher disease and plans to file an IND for this program in 2021.

About Fabry Disease

Fabry disease is an inherited, X-linked disease characterized by the progressive accumulation of glycosphingolipids in lysosomes throughout the body.It is caused by mutations in the gene encoding of the -galactosidase A (GLA) enzyme responsible for the breakdown of globotriaosylceramide (Gb3), a type of glycosphingolipid.

The condition ranges from mild to severe and may appear anytime from childhood to adulthood. The progressive accumulation of Gb3 leads to organ damage, major disability, and often early mortality. Symptoms and signs include neuropathic pain, impaired sweating, gastrointestinal symptoms, renal failure, heart disease and increased risk of stroke.Current treatment consists of ERT and chaperone therapy to temporarily clear Gb3 accumulation and alleviate symptoms.

About FLT190 for Fabry Disease

FLT190 is an investigational liver-directed AAV gene therapy for the treatment of Fabry disease. We believe the program is the first clinical-stage AAV gene therapy international study in Fabry disease. FLT190 is an in vivo gene therapy administered as a one-time intravenous infusion.

The study, named MARVEL-1, is a multi-center, international, dose-finding Phase 1/2 study in adult males with classic Fabry disease. The study is focused on assessing the safety of FLT190 and its ability to transduce liver cells to produce continuous high levels of GLA. In addition to safety, endpoints in the study include clearance of Gb3 and LysoGb3 from the plasma and urine, baseline renal and skin biopsies (repeated in long term follow up), renal and cardiac function, GLA immune response, viral shedding and quality of life.

About Freeline Therapeutics

Freeline is a clinical-stage biotechnology company developing transformative adeno-associated virus (AAV) vector-mediated gene therapies. The Company is dedicated to the mission of transforming patient lives with the ambition of developing innovative products to mediate functional cure through a one-time treatment paradigm for inherited systemic debilitating diseases. Freeline leverages a proprietary, rationally-designed capsid and AAV vector technology cassette that delivers a functional copy of a therapeutic gene into the human liver, delivering a durable level of missing proteins into the patients bloodstream. Freelines integrated expression platform includes capabilities in research, manufacturing, clinical development, and commercialization. The Company has clinical programs in Hemophilia B and Fabry disease, as well as preclinical programs in Gaucher disease and Hemophilia A.

Freeline is headquartered in the UK and has operations in Germany and the US.

Forward-Looking Statements

This press release contains statements that constitute forward looking statements as that term is defined in the United States Private Securities Litigation Reform Act of 1995, including statements that express the Companys opinions, expectations, beliefs, plans, objectives, assumptions or projections regarding future events or future results, in contrast with statements that reflect historical facts. Examples include discussion of the Companys manufacturing, research, pipeline, and clinical trial plans. In some cases, you can identify such forward-looking statements by terminology such as anticipate, intend, believe, estimate, plan, seek, project or expect, may, will, would, could or should, the negative of these terms or similar expressions. Forward looking statements are based on managements current beliefs and assumptions and on information currently available to the Company, and you should not place undue reliance on such statements. Forward-looking statements are subject to many risks and uncertainties, including the Companys recurring losses from operations; the development of the Companys product candidates, including statements regarding the timing of initiation, completion and the outcome of clinical studies or trials and related preparatory work and regulatory review; the Companys ability to design and implement successful clinical trials for its product candidates; the potential for a pandemic, epidemic or outbreak of infectious diseases in the US, UK or EU, including the COVID-19 pandemic, to disrupt the Companys clinical trial pipeline; the Companys failure to demonstrate the safety and efficacy of its product candidates; the fact that results obtained in earlier stage clinical testing may not be indicative of results in future clinical trials; the Companys ability to enroll patients in clinical trials for its product candidates; the possibility that one or more of the Companys product candidates may cause serious adverse, undesirable or unacceptable side effects or have other properties that could delay or prevent their regulatory approval or limit their commercial potential; the Companys ability to obtain and maintain regulatory approval of its product candidates; the Companys limited manufacturing experience which could result in delays in the development, regulatory approval or commercialization of its product candidates; and the Companys ability to identify or discover additional product candidates, or failure to capitalize on programs or product candidates. Such risks and uncertainties may cause the statements to be inaccurate and readers are cautioned not to place undue reliance on such statements. Many of these risks are outside of the Companys control and could cause its actual results to differ materially from those it thought would occur. The forward-looking statements included in this press release are made only as of the date hereof. The Company does not undertake, and specifically declines, any obligation to update any such statements or to publicly announce the results of any revisions to any such statements to reflect future events or developments, except as required by law. For further information, please reference the Companys reports and documents filed with theU.S. Securities and Exchange Commission. You may get these documents by visiting EDGAR on theSECwebsite atwww.sec.gov.

Contacts

David S. Arrington

Vice President Investor Relations & Corporate Communications

Freeline Therapeutics

david.arrington@freeline.life

+1 (646) 668 6947

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Freeline Presents Data on its Gaucher Disease and Fabry Disease AAV-Based Gene Therapies at the 17th Annual WORLDSymposium - PharmiWeb.com

Last year was hard on everyone. By mid-March, the reality of the coronavirus disease 2019 (COVID-19) pandemic began to set in around the globe, and much of the world shut down. Of course, veterinary hospitals did not have the luxury of shuttering their doors to protect themselves. In addition to your regular clientele, it seemed as though much of the world reacted to the stress of the pandemic by getting a puppy or a kitten. Once shelters were emptied and the reality of pet ownership set in, seemingly all of these new pets needed to be seen at your hospital. And you needed to be there for patients and clients.

Katie Buchanan, VMD, an associate veterinarian at Bayside Animal Medical Center in Severna Park, Maryland, and mother of a 1- and a 4-year-old, is doing everything she can to meet her clients needs, and it is still not enough. We are one of few [practices] in the area taking new clients, but we are overwhelmed, she says. I have nearly 30 callbacks in a day but no time to do them.

Whats more, because the practice is curbside, Buchanan spends much of her day on the phone. I dearly miss my clients and the bond we have. I hate that this is life right now, she says. But we cannot stay 6 feet apart from our staff, and we cannot keep this pace and go back to letting people in right now, or we will get a positive staff member and have to close.

Like Buchanan, you are likely busier than ever at your hospital, straining to meet the needs of a growing client roster while reworking the logistical flow of the entire practice to transform from a regular veterinary hospital to a full-service curbside machine. You are implementing new client communication technology and learning how to use it when all parties involved have a very short fuse. As you perform this magic, you may also be managing a revolving door of critical staff members testing positive for COVID-19 and needing to isolate for weeks, whether they are sick or not.

With no federally mandated safety policies, it is up to individual hospitals to create their own protocols and then try to get buy-in from staff to execute the plan. You may be at odds with your staff and clients on how to keep each other safe. You contact trace, you quarantine, and you worry about the safety of your clients, coworkers, and families. Are you really able to protect yourself and your family?

And then there are the clients, from the new owners who adopted a pet without considering the expense, training, and commitment involved to seasoned pet owners facing personal illnesses and economic uncertainty. A trip to the veterinarian is typically stressful for pets and their owners alike. Now they have the added stress of the virus, financial issues, masks, and a new paradigm for veterinary care in which they cannot accompany their pet inside, they cannot communicate in person with the veterinarian and staff, and they feel out of control. In short, clients are stressed, and many of them are taking it out on us.

Life is hard for veterinarians who are also mothers. The cost of veterinary school does not discriminate among genders or rely on ones parental status. As of 2018, both men and women paid between $148,807 and $407,983 for 4 years of veterinary school tuition, fees, and living expenses.1 According to the American Veterinary Medical Association, our profession was 61.8% women in 2018, but only 29.3% of practice owners were women.2 This matters because the average owner earns about $200,000 more than the average associate.3

Although there are no available data on how many veterinarians are parents, a 2015 survey of boarded large animal surgeons (published in 2019) reported that men (88%) were more likely than women (68%) to be married or in a domestic partnership and to have children (77% vs 47%, respectively). Yet women were more likely than men to require external childcare services and reported that having children had negatively impacted their professional lives.4 The same study showed that women earned less than men and were less likely to own a veterinary practice or hold a prestigious academic title. Men and women felt differently about the effect of gender in the workplace.

Female veterinarians pay for the same education and learn the same skills as their male counterparts. So why do women earn less, are less likely to hold a prestigious academic title, and are much less likely to own a practice? Bias and discrimination in the workplace are certainly at play here, but we also need to consider the effect of our home lives and domestic responsibilities when we think of career advancement. Here are some more statistics about gender differences in the US workforce:

Married mothers spend almost twice as much time on housework and childcare than married fathers.5

Mothers are far more likely to be working now than in past decades, yet they still spend more time on child care today than did moms in the 1960s.5

Success at work really means more work at home for women. The more economically dependent men are on their wives, the less housework they do. Even women with unemployed husbands spend considerably more time on household chores than their spouses.6

On top of an already untenable situation, we now find ourselves in a global pandemic, with many schools and daycares closed or operating virtually. So what now?

Meghan Knox, DVM, mother to a 16-month-old and a relief veterinarian in New Jersey, says what so many of us are feeling. I deeply crave a level of relaxation that I am simply unable to achieve, given the state of the world, she says. My family needs a vacation, someplace lovely like the Caribbean. My dentist recently determined that Ive been clenching my teeth from stress, so now I officially see physical manifestations of the stress of the past 8 months.

Knox has missed out on the normal practices of motherhood. Im still grieving the many losses of this yearmissed trips, missed first birthday celebration we had imagined for the baby, canceled weddings and showers, and family unable to travel to meet the baby. It is sadness and fatigue, and theres just zero patience left for anything else in any area of my life.

After reading this, are you surprised to hear that female veterinarians have a higher prevalence of risk factors for suicide, including depression and suicide ideation and attempts? According to 2018 data, female veterinarians are 2.4 times as likely as the general US population to commit suicide, whereas male veterinarians are 1.6 times as likely as the general US population.7

If you are a veterinarian and mother, you hold 2 roles, both of which require handling anything that comes your way with skill, alacrity, and infinite patience when everyone who depends on you is at maximum neediness day and night. You are on call 24/7. If they dont sleep, you dont sleep. You must anticipate and meet everyones needs in a world that is moving every single day. And, in the face of it all, you must maintain your composure and compassion and never, ever make a mistake.

Vet moms, let me be the first to tell you that you are managing the impossible and performing at a superhuman level. I am not afraid to say that sustaining the status quo is not tenable. Individually, each of you is keeping the world spinning on its axis each and every day. Collectively, you are a massive portion of a profession that is already under enormous stress. Together, we must reimagine both roles and create an organizational structure that supports the veterinarian mothers our profession depends on. The question is, how?

Liz Bales, VMD, has a special interest in the unique behavioral and wellness needs of cats. She is a writer, speaker, and featured expert in all things cat around the globe. Bales sits on the Deans Alumni Board at the University of Pennsylvania School of Veterinary Medicine and on the advisory boards for dvm360, AAFP Cat Friendly Practice, Vet Candy, and Fear Free.

References

1. How much does it cost to attend veterinary school? VIN Foundation. Accessed January 25, 2021. https://iwanttobeaveterinarian.org/how-much-does-it-cost-to-attend-veterinary-school/

2. Burns K. Census of veterinarians finds trends with shortages, practice ownership. American Veterinary Medical Association. June 26, 2019.Accessed January 25, 2021. https://www.avma.org/javma-news/2019-07-15/census-veterinarians-finds-trends-shortages-practice-ownership

3. Lee R. Is your veterinary practice ready to add an associate? Praxis. March 17, 2015. Accessed January 25, 2021. https://www.praxisvet.com/veterinary-practice-transition-blog/is-your-veterinary-practice-ready-to-add-an-associate#:~:text=Statistics%20show%20that%20an%20experienced,more%20than%20the%20average%20associate

4. Colopy SA, Buhr KA, Bruckner KB, Morello SL. The intersection of personal and professional lives for male and female diplomates of the American College of Veterinary Surgeons in 2015. J Am Vet Med Assoc. 2019;255(11):1283-1290. doi:10.2460/javma.255.11.1283 https://stats.oecd.org/index.aspx?queryid=54757

5. Bianchi SM, Sayer LC, Milkie MA, Robinson JP. Housework: who did, does or will do it, and how much does it matter? Soc Forces. 2012;91(1):55-63. doi:10.1093/sf/sos120

6. Rao AH. Even breadwinning wives dont get equality at home. The Atlantic. May 12, 2019. Accessed January 25, 2021. https://www.theatlantic.com/family/archive/2019/05/breadwinning-wives-gender-inequality/589237/

7. New study finds higher than expected number of suicide deaths among U.S. veterinarians. Press release. December 20, 2018. Accessed January 25, 2021. https://www.cdc.gov/media/releases/2018/p1220-veterinarians-suicide.html

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Veterinary medicine, motherhood, and a pandemic - DVM 360

David Brunner describes his work as a veterinarian as the most enjoyable profession in the world. I go to work and play with puppies and kittens. He credits his time as a student at Purdue University, capped by earning a Doctor of Veterinary Medicine degree in 1979, for fueling his passion.

Now, the new veterinary hospital at Purdue will be named the David and Bonnie Brunner Purdue Veterinary Medical Hospital Complex in recognition of a $10 million leadership commitment from David and Bonnie Brunner.

Purdue trustees approved the naming on Friday (Feb. 5).

The 162,500-square-foot complex will include three facilities located just east of the existing Lynn Hall of Veterinary Medicine:

* The David and Bonnie Brunner Small Animal Hospital, which will add 65,000 square feet to the existing small animal hospital facilities in Lynn Hall, which amount to about 40,000 square feet.

* The David and Bonnie Brunner Equine Hospital providing 73,000 square feet of new space.

* The David and Bonnie Brunner Farm Animal Hospital amounting to 24,000 square feet and replacing facilities in the existing large animal hospital.

As the pandemic has underscored, a state-of-the-art veterinary medicine program now not only benefits our animal population, but is an integral element in protecting human health, Purdue President Mitch Daniels said. Thanks to David and Bonnie, Indiana and the nation will now have such an invaluable asset.

David Brunner is the owner of the Broad Ripple Animal Clinic (BRAC), a business he founded on the north side of Indianapolis in 1981 with one employee. BRAC now has nine full-time veterinarians and is one of the 15% of hospitals in the U.S. accredited by the American Animal Hospital Association. Brunner retired as a practicing clinical veterinarian in 2012 but continues to be involved with the clinic as chief visionary and staff cheerleader.

Brunner has been a member of the Indiana Veterinary Medical Association, the American Veterinary Medical Association and the American Animal Hospital Association. He is a past president of the Indianapolis Humane Society, having previously served on the board for 10 years.In addition, Brunner has authored two books, The Dog Owners Manual and The Cat Owners Manual, currently published in 12 languages worldwide.

Bonnie (MacLeod) Brunner holds degrees in economics and comparative politics and an MBA in finance from UCLA. She retired from trading atMorganStanley and ownsLupo Design & Build, a luxury contemporary residential home building company in Hermosa Beach, California. She balances this business with her role as chief financial officer of the veterinary practice and managing the couples personal and commercial properties. Bonnie was actively involved in animal rescue organizations in Los Angeles before meeting David.

The Brunners split their time between Indianapolis; Southern California; and St. Barths, French West Indies.

My years at Purdue were life-changing, David Brunner said. It took me a while to appreciate the incredible education I received from Purdues vet school. To this day, I reflect with sincere appreciation on the many professors and clinical instructors who helped shape me into the veterinarian I became.

Bonnie and I have been presented with an extraordinary opportunity to contribute to the construction of the new veterinary medical complex. It is our hope that this contribution will aid and inspire veterinary students, now and for years to come. I am passionate about companion animal practice and have a special interest in inspiring the entrepreneurial spirit in vetstudents and teaching them theart of veterinary practice and thebusiness of veterinary medicine.

The couple is looking forward to having an active role in the Purdue Alumni Association and to finally attending some Boilermaker football games, as they joke, We did not have time to do things like that when we were in school because we were always studying.

The design of the new complex optimizes hands-on learning for students and creates dedicated space for community engagement opportunities. In addition, the complexs larger footprint and updated equipment will increase clinical research and allow faculty researchers to respond to more clinical trial opportunities, thus expanding the College of Veterinary Medicines reputation as a world-renowned research institute.

Due to the generosity of David and Bonnie Brunner, our vision of constructing a true state-of-the-art hospital is becoming a reality, said Willie M. Reed, dean of the College of Veterinary Medicine. The new hospital will provide a wonderful learning environment for our students, enable our faculty to advance their clinical research programs that involve clinical trials and greatly enhance our capability to deliver the highest quality care to our animal patients. I am especially grateful to have an alumnus of the college and his wife make such an impactful contribution to the colleges future success.

Slated to be completed by December and open by spring 2022, the new complex will provide for the varied needs of clients while also maximizing efficiency. For the first time, horses will have their own equine hospital rather than being treated at the same facility as farm animals like cows, pigs and sheep, which will be attended to at the new farm animal hospital. Efficiencies in the existing hospital facility will be incorporated into the new structures. For example, expensive imaging technology will be located centrally so it can be accessed from both the small animal and equine hospitals, which mirrors current practice in the existing facilities. Some small animal services will remain at the current small animal hospital.

In addition to treating animals, the hospital complex will serve as a catalyst for interdisciplinary research, including cancer drug discovery and the development of treatments for paralysis.

Total cost of the project is $108 million. Purdue has committed $35 million, which includes ongoing fundraising by the College of Veterinary Medicine, and the state of Indiana approved a $73 million appropriation.

Originally posted here:
Purdue Trustees Approve Naming of New Vet Hospital - Hoosier Ag Today

Max Filby|The Columbus Dispatch

The world is still in the midst of the coronavirus pandemic,but local researchers are working to stop the next outbreak right at the source.

COVID-19 is widely thought to have started in bats before jumping to another animal and then transmitting to humans in Wuhan, China, the original epicenter of the virus. That's why doctorsat Ohio State University's College of Veterinary Medicine are keeping a close eye on animals right now.

Their goal, is to make sure COVID-19 doesn't infect an animal, mutate, and then jump back into the human population. They've also got their eyes on a number of other emerging infectious diseases to try to prevent them from jumpstarting the next pandemic.

>>Read More: Some Ohio hospital workers got COVID vaccine even though they didn't fit rollout guidelines

"This type of surveillance, it's a needle in a haystack," said Dr. Vanessa Hale, assistant professor of veterinary preventive medicine. "What we are looking for may not be very widelypresent … But, if and when we find it, it will tell us some really important things about who can get a virus."

Viruses are sometimes nicknamed for the animal they jump from, such as the H1N1 "swine flu" that emerged in 2009 and the H5N1 "bird flu" that first showed up in 1996, according to the federalCenters for Disease Control and Prevention.

Ohio State researchers trying to prevent the next pandemic

Studying the way COVID-19 could jump from animals to humans is underway at the Ohio State College of Veterinary Medicine.

Doral Chenoweth, The Columbus Dispatch

Although animal surveillance is always conducted as a precaution against infectious diseases, it's taken on new visibility and importance in the age of COVID-19.

Coronaviruses are common in bats, but late last year it appeared that COVID-19 was able to jump from mink to humans. Denmark, which was home to a majority of the world's minksand is the biggest exporter of mink fur, ended up killing most of the animals out of fear that they could re-infect people.

An estimated 60% of known diseases, such asrabies, salmonella, West Nile virus and Lyme disease,can spread from animals, according to the CDC.Around 75% of new infectious diseases in people come from animals.

"The idea of emergingdiseases starting in an animal population and jumping to humans is definitely a big concern,"said Dr. Jenessa Winston, an assistant professor. "Alarge percentage of infectious diseases that jump into humans come from an animal source or have an animal reservoir."

Preventing the next outbreak before it begins is always the goal. Butthe coronavirus pandemic has made it clear that may not always be possible, which is why the world needs to be more prepared, said Dr. Joseph Gastaldo, medical director of infectious diseases at OhioHealth.

In the time since the pandemic began in mid-March, local, state and national leaders were forced to scramble to prepare for the worst.

Central Ohio leaders developed a blueprint for the Greater Columbus Convention Center to be transformed into a field hospital that luckily never came to fruition. Area hospitalsthat were once competitorshad to collaborate more closely to plan for asurge in cases.

While the quick planning proved successful, Gastaldo said it shouldn't have to come together at last minute. Instead, the U.S. should treat public health and its health care system more like its military.

>>Read More: COVID-19: Only 4% of Columbus vaccinations went to Black residents, mirroring state trend

"Just like 9/11, this changed everything," Gastaldo said. "Ifeel that COVID will leave us in a better position when it comes to the next pandemic. … This is equivalent to a world war."

If temporary measures like masking, distancing, curfews and stay-at-home orders are the epidemiological parallel towarfare, then what Hale and her colleagues do at Ohio State may be the frontline of defense.

Surveilling animals for emerging diseases has a long history and is used at many of the nation's zoos. Animals moved from one zoo to another sometimes have to be quarantined temporarily to make sure they don't introduce a virus to their new home.

While not perfect, keeping a close eye on critters for diseases is tried and true science, Hale said. When it comes to emerging diseases, Hale said,if people take care of animalsthey'll also be taking care of themselves.

She's hopeful coming out of the COVID-19 pandemic that there will be more of a push and more funding for research on emerging diseases in animals.

"It's hard to get people motivated to do a bunch of testing and surveillance of animals when they may come up with nothing," Hale said. "This is something that is going to receive more attention because it's critical we do this … to prevent future pandemics. It's thatintersectionof human health and environmental health."

mfilby@dispatch.com

@MaxFilby

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Ohio State veterinary researchers hope to prevent the next pandemic - The Columbus Dispatch

1

Established in 1969 in Newry, Norbrook is one of the largest, family owned, veterinary pharmaceutical companies in the world.

Their portfolio of trusted animal health products is distributed in more than 100 countries through their regional sales team and a network of longstanding distribution partners.

They have a history of product innovation, investing significantly in research and development, and they have a strong pipeline of products, a key growth driver for the company.

A career at Norbrook offers you an exceptional opportunity to achieve your potential with a world class global provider of veterinary pharmaceuticals enhancing the health of farm and companion animals.

The IT Project Manager is a unique role within the company and applications are open now.

2

The appointed staff nurse will work predominantly in the childs own home within the Western Trust but will also be required to work in the Childrens IPU.

They will participate in the assessment, planning and delivery of care to the children and the delegation of care to non-registered members of the care team promoting a philosophy of holistic care and active engagement of children and families.

The role will include both day and night duty.

The successful candidate will regularly report to and work under the direction of the Childrens Hospice Nurse Specialist Team Lead when working with the Community and Care Team Manager, ensuring that all aspects of care are carried out to the agreed standards and in accordance with all current policies and procedures of Northern Ireland Childrens Hospice.

This is a combined role based between Western Health & Social Care Trust Area & Horizon House IPU.

Sign up for your free jobseeker account with getgotjobs.co.uk. Well keep you informed about new job opportunities and youll also find a wealth of information, helpful hints and tips on how to secure your ideal job.

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A world leader of veterinary medicine in Newry and caring for children in the Western Trust: GetGot reveals exciting and rewarding new jobs - The...

Two Charlotte veterinarians say getting your pet vaccinated for COVID-19 isn't an option right now but interest is growing.

CHARLOTTE, N.C. A recent article from the New York Post about dogs and cats possibly needing the COVID-19 vaccine has pet owners talking on social media.

With vaccine supplies in short supply, some people are wondering when their pet would be eligible for a vaccine, if it's safe or whether they need it at all.

As Wake Up Charlotte viewers know, our pets are a big part of our lives, as well as our viewers. So, WCNC Charlotte's Rachel Lundberg went to two Charlotte veterinarians to get the answers.

So, do our dogs and cats need to be vaccinated for COVID-19? Here's what we learned after talking to two Charlotte veterinarians.

Marnie Gallagher, doctor of veterinarian medicine, at Armstrong Animal Clinic and Dr. Fred Wininger, a neurologist neurosurgeon at Charlotte Referral and Emergency, agreed that household pets are not a big concern for either suffering severe illness or spreading the virus that causes COVID-19.

"There have been no cases where an animal, specifically dog and cat, has transmitted it back to people," Wininger said. "...and then also, animals that do get infected, which is rare, are often asymptomatic."

For the cases confirmed in animals, the American Veterinary Medical Association (AVMA) tracks each diagnosis through an interactive map, which shows one case in South Carolina and two in North Carolina over the course of this pandemic.

"The one in North Carolina was last July, and it was a house dog, then there was a dog last November that was in a shelter situation," Gallagher said.

But even though the numbers are low, there is *interest*in potentially vaccinating our pets for COVID-19 down the road, especially following outbreaks detected in minks, which the New York Post also wrote about.

Enough *interest* that there are some companies that are looking at developing vaccines, Gallagher says.

"More for the big cats and minx than anything else, but none have been approved by the USDA," she added.

So, at this time, dogs and cats cannot get the COVID-19 vaccine, nor is it believed necessary.

"It is likely safe on most animals, but the efficacy of it in animals is unknown, and no dog or cat has died from the virus," Wininger said.

To read more about what the CDC says regarding COVID-19 and animals, click here.

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Do pets need to get the COVID-19 vaccine? - WFMYNews2.com

Researchers evaluated 17 widely available over-the-counter brands.

Getty Images

A team of researchers, led by a Texas A&M University professor, has found that some energy drinks have adverse effects on the muscle cells of the heart.

The study, led byDr. Ivan Rusyn, a professor in theVeterinary Integrative Biosciences (VIBS) Department at the Texas A&M College of Veterinary Medicine & Biomedical Sciences (CVMBS), was published in Food and Chemical Toxicology. In it, researchers observed cardiomyocytes human heart cells grown in a laboratory exposed to some energy drinks showed an increased beat rate and other factors affecting cardiac function.

Dr. Ivan Rusyn

Texas A&M College of Veterinary Medicine & Biomedical Sciences

When placed in the context of the human body, consumption of these beverages has been linked to improper beating of the heart, cardiomyopathy (disease of the heart muscle which makes it difficult for the heart to pump blood), increased blood pressure, and other heart conditions.

With the global sales of energy drinks estimated at $53 billion in 2018 and rapidly growing, it is important to understand the potential unintended health consequences associated with these beverages, according to Rusyn.

Because the consumption of these beverages is not regulated and they are widely accessible over the counter to all age groups, the potential for adverse health effects of these products is a subject of concern and needed research, Rusyn said. Indeed, the consumption of energy drinks has been associated with a wide range of adverse health effects in humans, many of them are concerning the effects on the heart.

Researchers evaluated 17 widely available over-the-counter brands. They then treated cardiomyocytes with each drink.

Researchers also studied the composition of the energy drinks using novel methods. By comparing the effects and differing ingredient concentrations in each drink, they were able to infer which ingredients may be contributing more to adverse effects on the treated cardiomyocytes. Using mathematical models, researchers determined that the possible presence of theophylline, adenine and azelate, substances which can have negative effects on the heart.

Little is known about the ingredients that may contribute to the adverse effects of energy drinks on the heart, Rusyn said. Specifically, the evidence for cardiovascular effects from studies in humans remains inconclusive, as the controlled clinical trials were largely limited in the number of participants. They were tested only a limited number of energy drink types, and are difficult to compare directly, because they employed different methods to evaluate the function of the cardiovascular system.

Further research is warranted on the ingredients identified in this study to ensure the safety of their consumption, especially by consumers with pre-existing health conditions.

This study shows that some of the tested energy drinks may have effects on human cardiomyocytes, and these data corroborate other studies in humans, Rusyn said. Therefore, we hope that the consumers will carefully weigh the performance-enhancing benefits of these beverages versus the emerging data that suggests that they may have real adverse effects.

We also hope that the Food and Drug Administration takes a closer look at whether these beverages may need to be carefully reviewed with respect to possible labeling of their adverse health effects, and whether certain age groups and susceptible sub-populations should be advised against consumption of these beverages.

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Texas A&M Researchers Discover Energy Drinks' Harmful Effects On Heart - Texas A&M University Today

Kortny Hahn|Cheboygan Daily Tribune

The Feb. 10 meeting of the Straits Area Audubon Society beginning at 7 p.m. will feature a presentation by Dr. Carl Palazzolo regarding medical care of wild birds.

This presentation is being done online, via Zoom, in order to allow members and others interested in the presentation to remain safe in their homes during the pandemic, while learning some new information. It is free and open to the public, with the link to the meeting being posted at http://www.straitsareaaudubon.com.

"Presenter Dr. Carl Palazzolo has served with the Long Beach Animal Hospital in California since graduating from Michigan State University Veterinarian School in 1978," said Jim Bricker of Straits Area Audubon Society. "Dr. Palazzolo spends summers near Harbor Springs."

Bricker said Palazzolo has been giving talks for several decades, all of which have been entertaining, informative and also sprinkled with some humor.

When Palazzolo is in Northern Michigan, he hosts veterinarian training programs to help new veterinarians gain experience and confidence in the growing field of wildlife care. His presentation will feature a behind-the-scenes view of providing medical care for injured wildlife and exotic animals, especially birds.

During his career, he has also donated his time for birds and other wild animals and taking care of them. He has also lead several trips to countries like Tsavo and Borneo to look at other wildlife such as lions and orangutans.

"His stories and examples will include the diagnosis, treatment, and release of a barn owl that was hanging by its wing under an overpass, a red-tailed hawk with a fractured wing, and repairing an injured eye on an owl. We are super excited to host him all the way from California," said Herm Boatin, Straits Area Audubon Society president.

The program will cover substantial medical information that is seldom available to the public. Some of the photos are graphic in nature because they are taken from actual surgical procedures.

Besides the general public who care about animals, the presentation is ideal for budding wildlife rehabbers and students who want to learn more about wildlife and veterinary medicine," said Boatin.

It is the goal of the Straits Area Audubon Society to educate the public about the natural environment. Normally, the monthly meetings of the group are hosted at the Cheboygan Area Public Library, in the downstairs meeting room. Due to the COVID 19 pandemic, the meetings have switched online, via Zoom.

More information on the Straits Area Audubon Society and the link to the program can be found at its website, http://www.straitsareaaudubon.com.

For more information on the presenter, Palazzolo, visit https://www.lbah.com/wildlife-care/. You can also click on the wildlife photography link on that site to learn more about his digital photography.

Carl Palazzolo will be the presenter at the Feb. 10 Straits Area Audubon Society online meeting, discussing the medical care of wild animals and birds. Courtesy photo

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Q: My neighbor's healthy young dog died suddenly of liver failure. The vet thinks the cause was aflatoxins in a new bag of dog food, since the food was later recalled. How can I prevent something similar from happening to my dog?

A: Aflatoxins are poisons produced by molds, particularly Aspergillus molds, that grow on grains such as corn and rice, as well as soybeans, tree nuts, peanuts and cottonseeds. These molds flourish under warm, moist growing and storage conditions.

Aflatoxins are not affected by heat, so they persist after food is processed. In December and January, Midwestern Pet Food recalled its Sportmix, Sportstrail, Nunn Better, Pro Pac and Splash pet foods after many dogs became ill or died after eating it, and testing showed very high levels of aflatoxins in the food.

In September and October, Sunshine Mills cited high aflatoxin levels when they recalled 17 brands of pet food.

While aflatoxins harm many animal species, dogs, especially puppies, are particularly sensitive.

Depending on how much aflatoxin is ingested, a dog can experience liver damage (even without clinical signs), liver failure or death. Aflatoxin exposure also causes liver cancer.

Signs of liver damage include decreased appetite and energy, regurgitation, diarrhea and jaundice, indicated by yellowing of the eyes, gums and skin. Clinical signs can begin within a day or two of ingestion or be delayed for weeks.

To protect your dog, buy pet food from large, well-established manufacturers with on-staff veterinary nutritionists who test the products in dogs. Ask your veterinarian for recommendations.

Store pet food in a clean, dry, cool place. Although most aflatoxin-tainted food doesn't show visible mold, don't feed moldy food or any food your dog suddenly dislikes, especially if it's from a new bag.

Never let your dog munch on livestock feed, because regulatory agencies permit aflatoxin levels to be 15 times higher in livestock feed than in pet food.

Q: A year ago, my wife took in Nugget, a stray kitten with long hair. My wife has obsessive-compulsive disorder, which manifests as compulsive housecleaning.

Because Nugget drops hair everywhere she goes, my wife locks her in a carrier 20 hours of every day. For the remaining few hours, Nugget is confined in one room to eat, drink and use the litter box.

We have a large house that I'm certain Nugget would enjoy exploring. It's too risky to let her go outdoors because of the predators in our rural area. I'd appreciate any ideas to persuade my wife to give Nugget the run of the house.

A: I'll begin by suggesting your wife consult her therapist about how her obsessive-compulsive disorder is affecting Nugget. Cognitive behavioral therapy, medication and other treatments can help.

Confining Nugget to a carrier most of each day is not only inhumane but can also contribute to a variety of health problems. For example, forcing her to hold her bladder all day increases her risk of urinary disease.

You can help by brushing Nugget daily, which should decrease the amount of hair around your home. Having her shaved also will decrease the volume of fur she sheds.

Fleas increase shedding, so make sure Nugget is treated throughout the year with a flea preventive. If she's shedding so much that her hair is sparse, make an appointment with her veterinarian.

If your wife remains unwilling to release Nugget from confinement, consider giving her to a family looking for an indoor cat to play throughout their home and snuggle with family members.

I'm certain your wife shares your desire to do what's best for Nugget. But you will have to take a stand to make that happen. Best wishes to all three of you.

Lee Pickett, VMD, practices companion animal medicine in North Carolina. Contact her at

vet@askthevet.pet

More here:
Dog food recall cites trace of deadly toxins - Arkansas Online

SHELTON, CT / ACCESSWIRE / February 8, 2021 / NanoViricides, Inc.. (NYSE American: NNVC) (the "Company") a global leader in the development of highly effective broad-spectrum antiviral therapies based on a novel nanomedicines platform has announced today that its broad-spectrum anti-coronavirus drug candidate for the treatment of COVID-19 infections was well tolerated in safety pharmacology studies required for progressing to human clinical trials.

The Company reports that its drug candidate NV-CoV-2 was found to be safe in the GLP safety pharmacology studies performed by an external contract research organization (CRO) in both rat and non-human primate (NHP) models. Additionally, multiple injections of NV-CoV-2 were also well tolerated in an extensive non-GLP study in rats that was performed by AR Biosystems, Inc., FL.

Based on the safety of NV-CoV-2 in these studies, the Company believes that projected dosages would be safe in human clinical trials. With these findings, the Company believes that it will be possible to administer repeated dosages of NV-CoV-2 in a human clinical trial, if needed, to achieve control over the coronavirus infection from SARS-CoV-2 or its variants.

In a GLP neuro-pulmonary safety pharmacology study in rats, the following conclusion was drawn: The intravenous administration of NV-CoV-2 at doses of 25, 50 and 100 mg/kg did not affect respiratory function in rats.

In a GLP cardiovascular function study in the NHP cynomolgus monkeys, the following conclusion was drawn: Intravenous infusion of NV-CoV-2 at 25, 37.5, and 50 mg/kg did not have any toxicologic effects on cardiac rhythm or ECG morphology in cynomolgus monkeys in this study. No significant effects on blood pressure and heart rate were observed after the intravenous infusion of NV-CoV-2.

These results were consistent with a more extensive, multiple injection non-GLP safety and tolerability study in Sprague-Dawley male and female rats. In this non-GLP study, NV-CoV-2 was injected intravenously (via tail vein) on each of days 0, 1, 2, 3, 4, and 5. Two different doses were used: 320mg/kg BW per injection, and 160 mg/kg BW per injection. Clinical observations, body weight, urine, blood chemistry, post-mortem findings, and organ histology were studied. In all parameters, NV-CoV-2 was well tolerated at both dosages throughout the study.

The Company has received draft reports from all of these studies. We anticipate receiving final audited reports on the GLP studies shortly.

The Company is preparing to submit a pre-IND application to the US FDA with safety tolerability and effectiveness data to obtain guidance regarding human clinical trials. Additionally, we are actively seeking opportunities to engage appropriate sites for human clinical trials. Further, we are engaged in the preparation of clinical trial protocols and other activities that would be necessary for submitting an IND application to the US FDA.

The need for the broad-spectrum, pan-coronavirus nanoviricide drug treatment cannot be overstated for combating the COVID-19 pandemic given the current circumstances and the present status of the pandemic. New virus variants continue to develop in the field. The variants that have advantages in terms of transmissibility, infectivity, and escape from drugs and vaccines will continue to evolve and spread, replacing prior variants. This is already well documented.

Several vaccines have been found to be substantially less effective in protecting against infection by the South African variant, N501Y-V.2 (also called lineage B.1.351) than the earlier variants. A mutation present in B.1.351 as well as Brazilian variant P.1 that is thought to be possibly linked to evasion from antibody drugs and vaccines, E484K, has also been reported in UK in a further differentiated mutant of the variant of concern lineage B.1.1.7. The available monoclonal antibody drugs and convalescent plasma antibodies have been reported to be less effective against several variants.

By the very nature of how they work, vaccines and antibodies tend to be highly specific to the target virus variant, and do not afford strong protection against differentiated variants that are evolutionary distant from the target variant. This scientific fact is now well demonstrated for the COVID-19 pandemic.

It is therefore clear that an effective broad-spectrum anti-coronavirus drug will be needed before the world can return to normal activity.

The Company previously had advanced NV-CoV-1 and had continued to work further with additional drug candidates. One of these drug candidates, namely, NV-CoV-2 was found to have several advantages over NV-CoV-1 in terms of manufacturability and dose formulation. Therefore the Company has advanced NV-CoV-2 into GLP safety/pharmacology studies.

NanoViricides is developing a broad-spectrum antiviral drug where the potential for escape of virus variants is minimized by the very design of the drug for the treatment of COVID-19 infected sick persons. In contrast, vaccines are not treatments for sick persons, and must be administered to healthy individuals, and further require several weeks for the recipient's immune system to become capable of protecting against the target virus strain which still may not protect against new virus variants circulating by that time.

NanoViricides has a strong advantage in that the Company has its own cGMP-capable manufacturing facility in Shelton, CT. This facility is capable of producing approximately 4kg of the COVID-19 drug per batch. We anticipate that this would be sufficient for human clinical trials, and possibly for initial introduction under Compassionate Use, Emergency Use Authorization or similar regulatory approval.

"We are pleased with the results of the safety pharmacology studies, and now we are confident that our COVID-19 drug candidate can advance into human clinical trials," said Anil R. Diwan, PhD, President and co-Founder of NanoViricides, Inc., and co-Inventor of its platform technologies and drug candidates.

About NanoViricides

NanoViricides, Inc. (the "Company")(www.nanoviricides.com) is a development stage company that is creating special purpose nanomaterials for antiviral therapy. The Company's novel nanoviricide class of drug candidates are designed to specifically attack enveloped virus particles and to dismantle them. Our lead drug candidate is NV-HHV-101 with its first indication as dermal topical cream for the treatment of shingles rash. In addition, we are developing a clinical candidate for the treatment of COVID-19 disease caused by SARS-CoV-2 coronavirus. The Company cannot project an exact date for filing an IND for this drug because of its dependence on a number of external collaborators and consultants.

The Company is now working on tasks for completing an IND application. The Company is currently pursuing two separate drug candidates for the treatment of COVID-19 patients. NV-CoV-2 is our nanoviricide drug candidate that does not encapsulate remdesivir. NV-CoV-2-R is our other drug candidate that is made up of NV-CoV-2 with remdesivir encapsulated in it. The Company believes that since remdesivir is already US FDA approved, our drug candidate encapsulating remdesivir is likely to be an approvable drug, if safety is comparable. Remdesivir is developed by Gilead. The Company has developed both of own drug candidates NV-CoV-2 and NV-CoV-2-R independently.

The Company intends to re-engage into an IND application to the US FDA for NV-HHV-101 drug candidate for the treatment of shingles once its COVID-19 project moves into clinical trials, based on resources availability. The NV-HHV-101 program was slowed down because of the effects of recent COVID-19 restrictions, and re-prioritization for COVID-19 drug development work.

The Company is also developing drugs against a number of viral diseases including oral and genital Herpes, viral diseases of the eye including EKC and herpes keratitis, H1N1 swine flu, H5N1 bird flu, seasonal Influenza, HIV, Hepatitis C, Rabies, Dengue fever, and Ebola virus, among others. NanoViricides' platform technology and programs are based on the TheraCour nanomedicine technology of TheraCour, which TheraCour licenses from AllExcel. NanoViricides holds a worldwide exclusive perpetual license to this technology for several drugs with specific targeting mechanisms in perpetuity for the treatment of the following human viral diseases: Human Immunodeficiency Virus (HIV/AIDS), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Rabies, Herpes Simplex Virus (HSV-1 and HSV-2), Varicella-Zoster Virus (VZV), Influenza and Asian Bird Flu Virus, Dengue viruses, Japanese Encephalitis virus, West Nile Virus and Ebola/Marburg viruses. The Company has executed a Memorandum of Understanding with TheraCour that provides a limited license for research and development for drugs against human coronaviruses. The Company intends to obtain a full license and has begun the process for the same. The Company's technology is based on broad, exclusive, sub-licensable, field licenses to drugs developed in these areas from TheraCour Pharma, Inc. The Company's business model is based on licensing technology from TheraCour Pharma Inc. for specific application verticals of specific viruses, as established at its foundation in 2005.

As is customary, the Company must state the risk factor that the path to typical drug development of any pharmaceutical product is extremely lengthy and requires substantial capital. As with any drug development efforts by any company, there can be no assurance at this time that any of the Company's pharmaceutical candidates would show sufficient effectiveness and safety for human clinical development. Further, there can be no assurance at this time that successful results against coronavirus in our lab will lead to successful clinical trials or a successful pharmaceutical product.

This press release contains forward-looking statements that reflect the Company's current expectation regarding future events. Actual events could differ materially and substantially from those projected herein and depend on a number of factors. Certain statements in this release, and other written or oral statements made by NanoViricides, Inc. are "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. You should not place undue reliance on forward-looking statements since they involve known and unknown risks, uncertainties and other factors which are, in some cases, beyond the Company's control and which could, and likely will, materially affect actual results, levels of activity, performance or achievements. The Company assumes no obligation to publicly update or revise these forward-looking statements for any reason, or to update the reasons actual results could differ materially from those anticipated in these forward-looking statements, even if new information becomes available in the future. Important factors that could cause actual results to differ materially from the company's expectations include, but are not limited to, those factors that are disclosed under the heading "Risk Factors" and elsewhere in documents filed by the company from time to time with the United States Securities and Exchange Commission and other regulatory authorities. Although it is not possible to predict or identify all such factors, they may include the following: demonstration and proof of principle in preclinical trials that a nanoviricide is safe and effective; successful development of our product candidates; our ability to seek and obtain regulatory approvals, including with respect to the indications we are seeking; the successful commercialization of our product candidates; and market acceptance of our products.

FDA refers to US Food and Drug Administration. IND application refers to "Investigational New Drug" application. cGMP refers to current Good Manufacturing Practices. CMC refers to "Chemistry, Manufacture, and Controls". CHMP refers to the Committee for Medicinal Products for Human Use, which is the European Medicines Agency's (EMA) committee responsible for human medicines.

Contact:NanoViricides, Inc.info@nanoviricides.com

Public Relations Contact:MJ ClyburnTraDigital IRclyburn@tradigitalir.com

SOURCE: NanoViricides, Inc.

View source version on accesswire.com:https://www.accesswire.com/628273/NanoViricidess-Broad-Spectrum-Antiviral-Drug-Candidate-for-the-Treatment-of-COVID-19-Infections-was-Well-Tolerated-in-GLP-and-non-GLP-Animal-Safety-Studies

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NanoViricides's Broad-Spectrum Antiviral Drug Candidate for the Treatment of COVID-19 Infections was Well Tolerated in GLP and non-GLP Animal Safety...

The Global Nanorobots In Blood Market Research Report Forecast 2021-2028 is a valuable source of insightful data for business strategists. It provides the Nanorobots In Blood industry overview with growth analysis and historical & futuristic cost, revenue, demand and supply data (as applicable). The research analysts provide an elaborate description of the value chain and its distributor analysis. This Nanorobots In Blood market study provides comprehensive data which enhances the understanding, scope and application of this report.

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Nanorobots In Blood Market Top-Vendor And Industry Analysis By End-User Segments Till 2028 | Aries Chemical, GE Water & Process Technologies KSU...

Janelle Overhouse and her dog Rory, a patient at Texas A&Ms Veterinary Medical Teaching Hospital.

Michael Kellett/Texas A&M College of Veterinary Medicine & Biomedical Sciences

Doctors at the Texas A&M University College of Veterinary Medicine & Biomedical Sciences (CVMBS) Veterinary Medical Teaching Hospital (VMTH) were recently confronted with a big problem how to save a dog from a first-of-its-kind critical illness.

First, the six-year-old boxer named Rory was infected by a rare form of Salmonella that has never before been seen in a dog. And second, her Salmonella infection was the first to be found in a dogs brain.

Rorys story begins long before her infection. She first became a patient when she was diagnosed with a common, but serious, form of meningitis when she was a year old.

During her first visit to the VMTH in 2015, Rory was diagnosed with Steroid Responsive Meningitis-Arteritis (SRMA), an immune-mediated inflammatory disease common in boxers that can cause neck pain and fever.

Id never even heard of SRMA and didnt know anything about it, said Rorys owner Janelle Overhouse. Once I learned more, I found that it was something that could be chronic. That was really scary, because she was in a tremendous amount of pain.

Luckily, Rorys form of SRMA could be treated with a few months of immunosuppressive steroids that, when finished, allow the dog to return to a completely normal life. While SRMA tends to repeatedly flare up over the years, it can usually be treated the same way with minimal complications.

For some patients, however, the immunosuppressed state during treatment can cause its own problems, such as when dealing with infections that could normally be fought off by a healthy immune system. This was the case when it came to Rorys unique infection.

In late 2019, Rory was undergoing the final months of treatment for her first SRMA relapse when she began to show unusual symptoms.

Rory came back to the VMTH because she had some issues that didnt really fit SRMA, said Dr. Melissa Andruzzi, the veterinary chief resident at the hospital.

She had seizures and her behavior was very different. Shes normally a really happy-go-lucky kind of dog who loves everyone and wants to lick everyone, but now she was afraid of people and a little bit aggressive toward people she didnt know. It was just very different for her.

Working with veterinary neurologist Dr. Beth Boudreau, a CVMBS assistant professor, Andruzzi scheduled an MRI for Rory and noticed that her brain looked abnormal in some places, another issue not connected to SRMA. She then extracted a sample of spinal fluid and sent it to CVMBS associate professor Dr. Sara Lawhon and graduate assistant Mary Krath at the VMTHs Clinical Microbiology Lab, who found the presence of the Salmonella called enterica subspecies houtenae.

The infection was likely a bacteremia, meaning it had spread in her blood and had access to her whole body, she said. The reason her central nervous system was particularly affected is because its natural barrier (the blood brain barrier) was already compromised from her SRMA, allowing easy access for the Salmonella.

Despite the novel aspects of Rorys case, she was treated much like any other patient with a serious infection with several months of antibiotics. Rorys SRMA was fully cleared by the time she began her Salmonella treatments, allowing her to stop taking the immunosuppressant steroids and fight the infection with her full immune system.

Once Rory was back on the road to full health, only one question remained: How did she become the first dog to contract that form of Salmonella?

After talking to Overhouse, Andruzzi came to the conclusion that wild geckos in her backyard might have been the source of the infection.

This form of Salmonella is most commonly identified in reptiles and amphibians, and more than 90% of reptiles are asymptomatic carriers. They contaminate whatever environment theyre in, Andruzzi said. Rory very commonly interacted with these little geckos outside and in the garage. So while we dont know for sure, we think it probably came from that.

Even after Rory went home healthy and happy, the work was not done for Andruzzi and her coworkers.

After we had treated her so successfully, we thought it was very important to write her case up so that if anyone else saw this type of Salmonella in a dog, or any other Salmonella in a dogs brain or spinal cord, they at least would have Rorys case to read about and see how we treated her, Andruzzi said. We needed to contribute this knowledge so that other veterinarians can treat other pets just as well.

But for Overhouse, the joy from finally seeing her dog healthy outshines all other positive aspects of Rorys case.

Rorys doing really well now. You wouldnt know anything happened to her, Overhouse said. Her veterinary team was great; they seemed to really listen and they were all very caring. I feel like they really had her best interests at heart and I appreciated that very much.

Ive not had many other kinds of dogs besides boxers, so I know theyre very people oriented. Rory follows me everywhere I go, she said. She is definitely connected to me and I to her. Im always looking out for her.

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Texas A&M Veterinarians Presented With First-Of-Its Kind Case - Texas A&M University Today

Veterinary Medicine Market Research Report by Mode of Delivery (Oral and Parenteral), by Product (Biologics, Medicated Feed Additives, and Pharmaceuticals), by Animal Type, by End-user - Global Forecast to 2025 - Cumulative Impact of COVID-19

New York, Feb. 03, 2021 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Veterinary Medicine Market Research Report by Mode of Delivery, by Product, by Animal Type, by End-user - Global Forecast to 2025 - Cumulative Impact of COVID-19" - https://www.reportlinker.com/p06007646/?utm_source=GNW

Market Statistics:The report provides market sizing and forecast across five major currencies - USD, EUR GBP, JPY, and AUD. This helps organization leaders make better decisions when currency exchange data is readily available.

1. The Global Veterinary Medicine Market is expected to grow from USD 22.77 Billion in 2019 to USD 34.93 Billion by the end of 2025.2. The Global Veterinary Medicine Market is expected to grow from EUR 20.33 Billion in 2019 to EUR 30.62 Billion by the end of 2025.3. The Global Veterinary Medicine Market is expected to grow from GBP 17.84 Billion in 2019 to GBP 27.22 Billion by the end of 2025.4. The Global Veterinary Medicine Market is expected to grow from JPY 2,482.38 Billion in 2019 to JPY 3,728.21 Billion by the end of 2025.5. The Global Veterinary Medicine Market is expected to grow from AUD 32.76 Billion in 2019 to AUD 50.72 Billion by the end of 2025.

Market Segmentation & Coverage:This research report categorizes the Veterinary Medicine to forecast the revenues and analyze the trends in each of the following sub-markets:

"The Parenteral is projected to witness the highest growth during the forecast period"

Based on Mode of Delivery, the Veterinary Medicine Market studied across Oral and Parenteral. The Parenteral commanded the largest size in the Veterinary Medicine Market in 2019, and it is expected to grow at the fastest CAGR during the forecast period.

"The Medicated Feed Additives is projected to witness the highest growth during the forecast period"

Based on Product , the Veterinary Medicine Market studied across Biologics, Medicated Feed Additives, and Pharmaceuticals. The Biologics further studied across DNA Vaccines, Inactivated Vaccines, Live attenuated vaccines, and Recombinant Vaccines. The Pharmaceuticals further studied across Analgesics, Anti-infectives, Anti-inflammatory, and Parasiticides. The Biologics commanded the largest size in the Veterinary Medicine Market in 2019. On the other hand, the Medicated Feed Additives is expected to grow at the fastest CAGR during the forecast period.

"The Production is projected to witness the highest growth during the forecast period"

Based on Animal Type, the Veterinary Medicine Market studied across Companion and Production. The Companion further studied across Cats, Dogs, and Horses. The Production further studied across Cattle, Fish, Poultry, Sheep & Goats, and Swine. The Companion commanded the largest size in the Veterinary Medicine Market in 2019. On the other hand, the Production is expected to grow at the fastest CAGR during the forecast period.

"The Point-of-care Testing/In-House Testing is projected to witness the highest growth during the forecast period"

Based on End-user, the Veterinary Medicine Market studied across Point-of-care Testing/In-House Testing, Reference Laboratories, and Veterinary Hospitals & Clinics. The Veterinary Hospitals & Clinics commanded the largest size in the Veterinary Medicine Market in 2019. On the other hand, the Point-of-care Testing/In-House Testing is expected to grow at the fastest CAGR during the forecast period.

"The Asia-Pacific is projected to witness the highest growth during the forecast period"

Based on Geography, the Veterinary Medicine Market studied across Americas, Asia-Pacific, and Europe, Middle East & Africa. The Americas region surveyed across Argentina, Brazil, Canada, Mexico, and United States. The Asia-Pacific region surveyed across Australia, China, India, Indonesia, Japan, Malaysia, Philippines, South Korea, and Thailand. The Europe, Middle East & Africa region surveyed across France, Germany, Italy, Netherlands, Qatar, Russia, Saudi Arabia, South Africa, Spain, United Arab Emirates, and United Kingdom. The Europe, Middle East & Africa commanded the largest size in the Veterinary Medicine Market in 2019. On the other hand, the Asia-Pacific is expected to grow at the fastest CAGR during the forecast period.

Company Usability Profiles:The report deeply explores the recent significant developments by the leading vendors and innovation profiles in the Global Veterinary Medicine Market including Archer-Daniels-Midland Company, Biogenesis Bago SA, C. H. Boehringer Sohn AG & Co. KG, Ceva Sante Animale, Dechra Pharmaceuticals PLC, Elanco Animal Health Incorporated, Evonik Industries AG, Hester Biosciences Limited, Indian Immunologicals Ltd, Kindred Biosciences, Inc., Merck & Co. Inc., Neogen Corporation, Nutreco N.V., Phibro Animal Health Corporation, Vetoquinol S.A., Virbac SA, and Zoetis Inc..

Cumulative Impact of COVID-19:COVID-19 is an incomparable global public health emergency that has affected almost every industry, so for and, the long-term effects projected to impact the industry growth during the forecast period. Our ongoing research amplifies our research framework to ensure the inclusion of underlaying COVID-19 issues and potential paths forward. The report is delivering insights on COVID-19 considering the changes in consumer behavior and demand, purchasing patterns, re-routing of the supply chain, dynamics of current market forces, and the significant interventions of governments. The updated study provides insights, analysis, estimations, and forecast, considering the COVID-19 impact on the market.

360iResearch FPNV Positioning Matrix:The 360iResearch FPNV Positioning Matrix evaluates and categorizes the vendors in the Veterinary Medicine Market on the basis of Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) that aids businesses in better decision making and understanding the competitive landscape.

360iResearch Competitive Strategic Window:The 360iResearch Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies. The 360iResearch Competitive Strategic Window helps the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. During a forecast period, it defines the optimal or favorable fit for the vendors to adopt successive merger and acquisition strategies, geography expansion, research & development, and new product introduction strategies to execute further business expansion and growth.

The report provides insights on the following pointers:1. Market Penetration: Provides comprehensive information on the market offered by the key players2. Market Development: Provides in-depth information about lucrative emerging markets and analyzes the markets3. Market Diversification: Provides detailed information about new product launches, untapped geographies, recent developments, and investments4. Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, and manufacturing capabilities of the leading players5. Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and new product developments

The report answers questions such as:1. What is the market size and forecast of the Global Veterinary Medicine Market?2. What are the inhibiting factors and impact of COVID-19 shaping the Global Veterinary Medicine Market during the forecast period?3. Which are the products/segments/applications/areas to invest in over the forecast period in the Global Veterinary Medicine Market?4. What is the competitive strategic window for opportunities in the Global Veterinary Medicine Market?5. What are the technology trends and regulatory frameworks in the Global Veterinary Medicine Market?6. What are the modes and strategic moves considered suitable for entering the Global Veterinary Medicine Market?Read the full report: https://www.reportlinker.com/p06007646/?utm_source=GNW

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Veterinary Medicine Market Research Report by Mode of Delivery, by Product, by Animal Type, by End-user - Global Forecast to 2025 - Cumulative Impact...

DAVIS, Calif. (KTXL) Three women studying veterinary medicine at the University of California, Davis recently discovered they have a lot more in common than an interest in helping animals.

Their lives are linked by a series of remarkable coincidences stretching all the way from a province in China to the campus of UC Davis.

Molly Mettler, Livvy Peterson and Jennie Furth-Jacobus are all first-year veterinary students. Theyre all left-handed and they all played volleyball in high school. They each grew up in Southern California. In fact, Mettler and Furth-Jacobus lived just 10 minutes from each other in Los Angeles. They never met until they got to UC Davis.

But the bond between the three goes far beyond common interests or characteristics. During a conversation last semester, they realized their life stories coincide on a much deeper level.

We just kind of started talking and introducing ourselves and we got around to talking about how we were all adopted from China. And then we got to, like, Oh, where in China? Peterson said. And we were from the same province: in Guangdong.

And so we really bonded over that, Furth-Jacobus said.

Then we talked more about it, the details of it, Mettler added.

They were each abandoned as infants by their birth parents and placed in orphanages in Guangdong province.

From there, they were all adopted by American parents through the same adoption agency, and never having met, they each pursued veterinary medicine degrees and got accepted into the prestigious program at UC Davis.

Like a What are the odds? kind of thing, Peterson said.

I cant wrap my head around it still, Mettler said.

And then to have us in the first year together in the same class its crazy, Furth-Jacobus said.

In the same lab group too, Mettler added.

Oh yeah, and were in the same lab group, Furth-Jacobus agreed.

Because were divided into four different groups, Mettler said. So the chances of even just being put in the same group too is even slimmed down more.

During a time when lectures are given online for COVID-19 safety, the labs provide that rare space where class is conducted in-person. And thats how the friends really got to know each other.

Weve been very grateful to have in-person labs, Furth-Jacobus said.

Yeah, its something that were definitely not taking for granted, Mettler added.

Especially when we havent really gotten a lot of chances to meet a lot of our classmates. So then having something else that connects you deeper is like, you know, another step, Peterson said. So I think thats really cool.

Clearly, gratitude is also on the list of things the three have in common. That gratitude extends to the parents who adopted them and, with understanding hearts, to the birth parents who surrendered them.

I know that they did their best and that circumstances were just really tough, Furth-Jacobus said.

Its one of those things that was kind of meant to be, Peterson said. Like Im personally really happy that I ended up here in America with my American family that I did.

I mean, were here at UC Davis, the number one vet school in the world. So Im grateful for the sacrifices that they made so that I could have a better life, Furth-Jacobus added.

Thats amazing that were here together and weve experienced that, Mettler said.

The rest is here:
What are the odds?: UC Davis veterinary students discover they were adopted from the same Chinese province - KTXL FOX 40 Sacramento