StemCell Therapy

Joel Fuhrman, M.D.

Excess dietary salt is notorious for increasing blood pressure – blood volume increases, placing more stress on blood vessel walls. This forces the heart to pump harder against the pressure, and also structural changes that harden the vessel wall (this hardening is called stenosis) occur in response to these high pressures.
About one-third of all American adults and over 50% of those over the age of 55 have hypertension, and hypertension carries significant risks. Elevated blood pressure accounts for 62% of strokes and 49% of coronary heart disease. [1] Notably, the risk for heart attack and stroke begins climbing with systolic pressures (first number in the blood pressure reading) above 115 mm Hg – considered “normal” by most standards.[2] Also, dietary salt is not only dangerous to the cardiovascular system, but also contributes to kidney disease, osteoporosis , ulcers, and stomach cancer. [3] Read more...

Body cleansing, Body detoxify

Joel Fuhrman, M.D.

Excess dietary salt is notorious for increasing blood pressure – blood volume increases, placing more stress on blood vessel walls. This forces the heart to pump harder against the pressure, and also structural changes that harden the vessel wall (this hardening is called stenosis) occur in response to these high pressures.
About one-third of all American adults and over 50% of those over the age of 55 have hypertension, and hypertension carries significant risks. Elevated blood pressure accounts for 62% of strokes and 49% of coronary heart disease. [1] Notably, the risk for heart attack and stroke begins climbing with systolic pressures (first number in the blood pressure reading) above 115 mm Hg – considered “normal” by most standards.[2] Also, dietary salt is not only dangerous to the cardiovascular system, but also contributes to kidney disease, osteoporosis , ulcers, and stomach cancer. [3] Read more...

Body cleansing, Body detoxify

The human eye is a biological marvel. Charles Darwin considered it one of the biggest challenges to his theory of evolution, famously writing : that “To suppose that the eye with all its inimitable contrivances for adjusting the focus to different distances, for admitting different amounts of light, and for the correction of spherical and chromatic aberration, could have been formed by natural selection, seems, I freely confess, absurd in the highest degree.” Of course he did go on to explain how natural selection could account for the eye, but we can see why he wrote these words under the heading of “Organs of Extreme Perfection and Complication.” [More]

International Stem Cell Corporation Demonstrates Progress in the Use of Immune Matched Human Parthenogenetic Stem Cells to Promote the Development of Therapies for Diabetes and Liver Diseases

International Stem Cell Corporation (OTCBB:ISCO), http://www.internationalstemcell.com, together with colleagues from ViaCyte (formerly Novocell), announced the successful derivation from its human parthenogenetic stem cells (hpSCs) of enriched cultures of definitive endoderm (DE). DE can be further developed into pancreas or liver cells. These new results create a platform for the development by ISCO of therapeutic products that have great potential to overcome the problem of rejection of transplanted cells by the patient's own immune system.

The results are described in a new article that will appear in Differentiation, the official journal of the International Society of Differentiation, published by Elsevier. The article concludes that, "Creation of the definitive endoderm lineages from hpSC represents the critical first step toward the development of hpSC-based cellular therapies for diseases of the liver or pancreas."

The article also describes improvement in an earlier published differentiation protocol. This new method extends ISCO's portfolio of intellectual property, demonstrating for the first time that the pre-treatment of undifferentiated cells by trichostatin A (TSA) significantly improves the efficacy of the differentiation procedure.

"This work represents a step forward in our ability to direct the differentiation of hpSCs to cell populations of sufficient purity for their eventual use to produce commercially viable populations of endoderm lineage cells such as liver and pancreas," said Nikolay Turovets, PhD, ISCO's Director of Research and Therapeutic Development, and the paper's co-author.

The published work was carried out in collaboration with scientists from ViaCyte, a leader in the direct differentiation of pluripotent stem cells toward definitive endoderm and pancreatic cells. The ViaCyte team was led by Dr. Baetge, currently Director of the Nestlé Institute of Health Sciences S.A., Lausanne, Switzerland, and Dr. D'Amour, ViaCyte's Director of Stem Cell Biology, both pioneers in the development of endoderm from human embryonic stem cells.

Andrey Semechkin, PhD, ISCO's CEO and the paper's co-author, said: "The fact that hpSC could be differentiated into progenitors of pancreatic and liver cells have now become a proven scientific fact. This data establishes hpSCs as a useful source of starting material in stem-cell based technologies and demonstrates excellent progress in therapeutic research."

According to earlier published scientific data, the most efficient method for deriving pancreatic and liver cells from human pluripotent stem cells is a method of direct differentiation that utilizes treatment of the stem cell cultures by specific signals directing differentiation toward particular lineages. Therefore it is extremely important that stem cells used for the differentiation process are able to respond to such signaling. Dr. Semechkin commented, "In this published paper we report for the first time that hpSCs can respond to well characterized differentiation signals. Moreover, we demonstrate that these unique cells respond to similar signaling factors and demonstrate gene expression dynamics and transitions that simulate properties of DE differentiation during vertebrate development and closely follow differentiation of human embryonic stem cells to DE. These data are extremely important as they demonstrate that hpSCs have therapeutic potential; however, parthenogenetic stem cells have an additional benefit of superior immune-matching capabilities and don't pose the same ethical questions associated with embryonic stem cells."

The Abstract of the paper is available on the Elsevier web site. The title of the paper is: "Human parthenogenetic stem cells produce enriched populations of definitive endoderm cells after trichostatin A pretreatment."

Full text article can be obtained upon request to corresponding author, Nikolay Turovets, PhD: nturovets@intlstemcell.com.

Additional information regarding ISCO's therapeutic projects is available on the ISCO website:http://www.internationalstemcell.com/therapeutics.htm.

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):

International Stem Cell Corporation is a California-based biotechnology company focused on the therapeutic applications of human parthenogenetic stem cells and the development and commercialization of cell-based research and cosmetic products. ISCO's core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology and cell-based skin care products through its subsidiary Lifeline Skin Care. More information is available at ISCO's website, http://www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS

Statements pertaining to anticipated technological developments and potential therapeutic applications, and other opportunities for the company and its subsidiaries, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
or
Nikolay Turovets, PhD
nturovets@intlstemcell.com

The human eye is a biological marvel. Charles Darwin considered it one of the biggest challenges to his theory of evolution, famously writing : that “To suppose that the eye with all its inimitable contrivances for adjusting the focus to different distances, for admitting different amounts of light, and for the correction of spherical and chromatic aberration, could have been formed by natural selection, seems, I freely confess, absurd in the highest degree.” Of course he did go on to explain how natural selection could account for the eye, but we can see why he wrote these words under the heading of “Organs of Extreme Perfection and Complication.” [More]

International Stem Cell Corporation Demonstrates Progress in the Use of Immune Matched Human Parthenogenetic Stem Cells to Promote the Development of Therapies for Diabetes and Liver Diseases

International Stem Cell Corporation (OTCBB:ISCO), http://www.internationalstemcell.com, together with colleagues from ViaCyte (formerly Novocell), announced the successful derivation from its human parthenogenetic stem cells (hpSCs) of enriched cultures of definitive endoderm (DE). DE can be further developed into pancreas or liver cells. These new results create a platform for the development by ISCO of therapeutic products that have great potential to overcome the problem of rejection of transplanted cells by the patient's own immune system.

The results are described in a new article that will appear in Differentiation, the official journal of the International Society of Differentiation, published by Elsevier. The article concludes that, "Creation of the definitive endoderm lineages from hpSC represents the critical first step toward the development of hpSC-based cellular therapies for diseases of the liver or pancreas."

The article also describes improvement in an earlier published differentiation protocol. This new method extends ISCO's portfolio of intellectual property, demonstrating for the first time that the pre-treatment of undifferentiated cells by trichostatin A (TSA) significantly improves the efficacy of the differentiation procedure.

"This work represents a step forward in our ability to direct the differentiation of hpSCs to cell populations of sufficient purity for their eventual use to produce commercially viable populations of endoderm lineage cells such as liver and pancreas," said Nikolay Turovets, PhD, ISCO's Director of Research and Therapeutic Development, and the paper's co-author.

The published work was carried out in collaboration with scientists from ViaCyte, a leader in the direct differentiation of pluripotent stem cells toward definitive endoderm and pancreatic cells. The ViaCyte team was led by Dr. Baetge, currently Director of the Nestlé Institute of Health Sciences S.A., Lausanne, Switzerland, and Dr. D'Amour, ViaCyte's Director of Stem Cell Biology, both pioneers in the development of endoderm from human embryonic stem cells.

Andrey Semechkin, PhD, ISCO's CEO and the paper's co-author, said: "The fact that hpSC could be differentiated into progenitors of pancreatic and liver cells have now become a proven scientific fact. This data establishes hpSCs as a useful source of starting material in stem-cell based technologies and demonstrates excellent progress in therapeutic research."

According to earlier published scientific data, the most efficient method for deriving pancreatic and liver cells from human pluripotent stem cells is a method of direct differentiation that utilizes treatment of the stem cell cultures by specific signals directing differentiation toward particular lineages. Therefore it is extremely important that stem cells used for the differentiation process are able to respond to such signaling. Dr. Semechkin commented, "In this published paper we report for the first time that hpSCs can respond to well characterized differentiation signals. Moreover, we demonstrate that these unique cells respond to similar signaling factors and demonstrate gene expression dynamics and transitions that simulate properties of DE differentiation during vertebrate development and closely follow differentiation of human embryonic stem cells to DE. These data are extremely important as they demonstrate that hpSCs have therapeutic potential; however, parthenogenetic stem cells have an additional benefit of superior immune-matching capabilities and don't pose the same ethical questions associated with embryonic stem cells."

The Abstract of the paper is available on the Elsevier web site. The title of the paper is: "Human parthenogenetic stem cells produce enriched populations of definitive endoderm cells after trichostatin A pretreatment."

Full text article can be obtained upon request to corresponding author, Nikolay Turovets, PhD: nturovets@intlstemcell.com.

Additional information regarding ISCO's therapeutic projects is available on the ISCO website:http://www.internationalstemcell.com/therapeutics.htm.

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):

International Stem Cell Corporation is a California-based biotechnology company focused on the therapeutic applications of human parthenogenetic stem cells and the development and commercialization of cell-based research and cosmetic products. ISCO's core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology and cell-based skin care products through its subsidiary Lifeline Skin Care. More information is available at ISCO's website, http://www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS

Statements pertaining to anticipated technological developments and potential therapeutic applications, and other opportunities for the company and its subsidiaries, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
or
Nikolay Turovets, PhD
nturovets@intlstemcell.com

A recently-released report by the Environmental Working Group (EWG) has found that the water supplies of many major cities are contaminated with hexavalent chromium, an industrial chemical toxin that does not get filtered out by most consumer water filtration devices. Thirty-one of the 35 water supplies tested contained hexavalent chromium, and 25 of them contained levels higher than a California-proposed maximum upper threshold for safety.

Topping the list of contaminated water supplies was Norman, Okla., with 12.9 parts per billion (ppb) of hexavalent chromium, followed by Honolulu, Hawaii, at 2.0 ppb and Riverside, Calif., at 1.69 ppb. Other highly-tainted cities include Madison, Wisc., San Jose, Calif., Tallahassee, Fla., and Albuquerque, N.M.

According to the National Toxicology Program, hexavalent chromium, also known as chromium-6, is linked to causing gastrointestinal tumors and other forms of cancer. International governing bodies have stated that it is toxic when inhaled. And the U.S. Environmental Protection Agency (EPA) has declared hexavalant chromium "likely to be carcinogenic to humans." Read more...

Cardiofy Heart Care Supplement

GENEVIEVE CARBERY
Tue, Nov 02, 2010

A new study found alcohol was the most dangerous of 20 legal and illegal drugs when the two criteria of harm to the user and harm to others were combined ALCOHOL IS more dangerous than crack cocaine and heroin when damage to users themselves and to wider society are combined, a study has found. The research, published yesterday in theLanc et medical journal, rated alcohol almost three times as harmful as cocaine or tobacco and some eight times as harmful as ecstasy. Alcohol was found to be the most harmful of 20 legal and illegal drugs examined when the two criteria of harm to the user and harm to others were combined. The study was conducted by a group of scientists including Britain’s Independent Scientific Committee on Drugs and an expert adviser to the European Monitoring Centre for Drugs and Drug Addiction. Read more...

Cardiofy Heart Care Supplement

Most people do their best to avoid contact with Salmonella . This bacteria genus, which often lives on poultry and can find its way into other food products , causes hundreds of thousands of illnesses--and hundreds of deaths--in the U.S. each year. But new research demonstrates that this common food pathogen could be disarmed and reconfigured as a vehicle for gene-based antiviral treatments. [More]

Over 1.5 million new cancer cases were identified in the United States in 2010, and despite continued advances in cancer treatment, approximately 500,000 cancer-related deaths occurred in the same year (1). For a long time, cancer therapies were a one-size-fits-all, depending on the cancer type. In recent years however, the need has emerged to develop a more enlightened paradigm in which treatments are better tailored towards the individual uniqueness of the cancer (2).

Personalized Medicine is a catch phrase that reflects the current understanding that no two patients are alike. The primary goal of personalized medicine is to develop patient-specific treatments that can hopefully reduce unnecessary side effects as well as the overall cost of cancer care by using therapies that are most likely to be effective in the population that is most likely to benefit (3).

[More]

AstraZeneca Pharmaceuticals LP (NYSE: AZN) and HealthCore, Inc., the health outcomes research subsidiary of WellPoint, Inc. (NYSE: WLP), announced a collaborative agreement to conduct real-world studies designed to determine how to most effectively and economically treat disease

Unlike controlled clinical trials, real-world evidence studies use observational data such as electronic medical records, claims information and patient surveys. By examining data associated with the delivery of care, real-world analyses can assess treatment impact on hospital length of stay, readmissions, overall health status, cost of care and other key evidence-based outcomes.

A leader in health outcomes research, HealthCore maintains the largest data environment in the nation. HealthCore’s near real-time, fully-integrated data environment combines medical, pharmacy, laboratory results and other information drawn from 36 million enrollees in local Blue Cross and/or Blue Shield plans with concentrated populations in 16 states.

A recently-released report by the Environmental Working Group (EWG) has found that the water supplies of many major cities are contaminated with hexavalent chromium, an industrial chemical toxin that does not get filtered out by most consumer water filtration devices. Thirty-one of the 35 water supplies tested contained hexavalent chromium, and 25 of them contained levels higher than a California-proposed maximum upper threshold for safety.

Topping the list of contaminated water supplies was Norman, Okla., with 12.9 parts per billion (ppb) of hexavalent chromium, followed by Honolulu, Hawaii, at 2.0 ppb and Riverside, Calif., at 1.69 ppb. Other highly-tainted cities include Madison, Wisc., San Jose, Calif., Tallahassee, Fla., and Albuquerque, N.M.

According to the National Toxicology Program, hexavalent chromium, also known as chromium-6, is linked to causing gastrointestinal tumors and other forms of cancer. International governing bodies have stated that it is toxic when inhaled. And the U.S. Environmental Protection Agency (EPA) has declared hexavalant chromium "likely to be carcinogenic to humans." Read more...

Cardiofy Heart Care Supplement

GENEVIEVE CARBERY
Tue, Nov 02, 2010

A new study found alcohol was the most dangerous of 20 legal and illegal drugs when the two criteria of harm to the user and harm to others were combined ALCOHOL IS more dangerous than crack cocaine and heroin when damage to users themselves and to wider society are combined, a study has found. The research, published yesterday in theLanc et medical journal, rated alcohol almost three times as harmful as cocaine or tobacco and some eight times as harmful as ecstasy. Alcohol was found to be the most harmful of 20 legal and illegal drugs examined when the two criteria of harm to the user and harm to others were combined. The study was conducted by a group of scientists including Britain’s Independent Scientific Committee on Drugs and an expert adviser to the European Monitoring Centre for Drugs and Drug Addiction. Read more...

Cardiofy Heart Care Supplement

Eminent geologist Jane Plant is now promoting a dietary program for the treatment of cancer, saying that going dairy-free and eating cancer-protective foods helped cure her breast cancer where conventional Western medicine had failed.

Plant was first diagnosed with cancer at age 42. Over the next five years, the cancer recurred four times "despite a radical mastectomy, three further operations, 35 radiotherapy treatments, several chemotherapy treatments and irradiation of my ovaries to induce the menopause," she writes in her book Your Life in Your Hands.

After the discovery of a cancerous lump in her neck, Plant came across statistics detailing the low rates of breast and prostate cancer in China. Since dairy is almost never consumed in China, she cut it out of her diet entirely and limited her intake of foods containing high levels of chemicals and hormones. She built her diet around foods that have been shown to protect against cancer.

The idea of a connection between diet and cancer is not new.

"The American Cancer Society estimates that of the 500,000 cancer deaths that occur in the United States, about one-third can be attributed to dietary factors, with another third being caused by cigarette smoking," writes Phyllis A. Balch in her book Prescription for Nutritional Healing, 4th Edition. Read more...

Cardiofy Heart Care Supplement

The very reputation of so-called "science" has been irreparably damaged by the invocation of the term "science" by GMO lackeys, pesticide pushers, mercury advocates and fluoride poisoners who all claim to have science on their side. It seems that every toxin, contamination and chemical disaster that now infects our planet has been evangelized in the name of "science."

Where "science" used to be highly regarded in the 1950's, today the term is largely exploited by pharmaceutical companies, biotech giants and chemical companies to push their own for-profit agendas. Actual science has little to do with the schemes now being pushed under the veil of science.

To make matters even worse for the sciences, many so-called "science bloggers" have been revealed to have financial ties to the very same companies whose profits are shored up by their activities (http://www.ageofautism.com/2010/08/the-new-york-times-exposes-scienceblogs.html).

Rather than defending any sort of scientific truth, science bloggers have become the internet whores of Big Pharma, Monsanto, pesticide manufacturers, chemical companies and toxic mercury factories. There's hardly a dangerous chemical in widespread use today that the science bloggers haven't venomously defended as safe and effective. Many are just blatantly paid off by corporate entities to run around the internet pushing GMOs, chemicals and vaccines. Read more...

Immunice for Immune Support

Mercury-Caused Endocrine Conditions Causing Widespread Adverse Health Effects, Cognitive Effects, and Fertility Effects B.Windham(Ed.)http://www.home.earthlink.net/~berniew1/endohg.html

Introduction.
As will be documented in this paper, the majority of the population receives significant mercury exposures and significant adverse health effects are common. Mercury has been found to be an endocrine system disrupting chemical in animals and people, disrupting function of the pituitary gland, thyroid gland, thymus gland, adrenal gland, enzyme production processes, and affecting many hormonal functions at very low levels of exposure . The main factors determining whether chronic conditions are induced by metals appear to be exposure and genetic susceptibility, which determines individuals immune sensitivity and ability to detoxify metals(405). Very low levels of exposure have been found to seriously affect large groups of individuals who are immune sensitive to toxic metals, or have an inability to detoxify metals due to such as deficient sulfoxidation or metallothionein function or other inhibited enzymatic processes related to detoxification or excretion of metals. Read more...

Ayurtox for Body Detoxification

Millions of Americans have difficulty falling asleep or staying asleep, resulting in excessive fatigue and even more serious consequences. According to the Centers for Disease Control (CDC): "Insufficient sleep is associated with a number of chronic diseases and conditions such as diabetes, cardiovascular disease, obesity, and depression...it is also responsible for motor vehicle and machinery-related accidents."

Of course, Big Pharma has come up with a huge array of supposedly easy solutions for those who have a hard time getting enough shut-eye. All you have to do is pop a pill such as the heavily hyped Sonata, Rozerem, Lunesta or Silenor and you'll soon be snoozing away happily, the drug advertisements promise. Of course, you might decide that's not the healthiest idea if you check out the side effects which can include hallucinations, thoughts of suicide, loss of coordination, fever, "sleep driving" while not fully awake and memory problems. Read more...

Immunice for Immune Support