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New Report from University of Pittsburgh Regarding Stem Cells and Anti Aging – Video

February 21st, 2012 8:49 am

20-01-2012 10:50 University of Pittsburgh announces a new finding from their stem cell research. The aging process is stalled using young stem cells from the fat of young mice. Published in Nature Communications and reported on Fox TV, Dr. Niedernhofer and Dr. Huard expressed their excitement on the possibilities of this new research.

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Korea Tooth Stem Cell Bank, Inc. – Video

February 21st, 2012 8:49 am

16-01-2012 19:46 Korea Tooth Stem Cell Bank, Inc. aired on TV media.

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Stem cells – ISWA project – Video

February 21st, 2012 8:49 am

14-02-2012 08:13 STEM CELLS The dance of life Recent developments in regenerative medicine and modern biology are going to have an enormous impact on our lives. Also the way itself we face the problem of sickness, aging and death changes as the hope (or the illusion?) grows that we always can fight and delay them. Stem cell research is in fact changing our knowledge of the fundamental mechanisms of life and feeding the idea that we can increasingly contrast the cruel natural selection rules which make us fall ill, grow old and die. A new frontier opens and unpredictable changes in our culture are taking place. People's hopes and fears grow at the same time. The general properties of the stem cells is presented, namely the ability to proliferate and, under certain conditions, to differentiate in other types of cells. In this way they can generate a new tissue replacing a damaged one, and also a new organ (like blood, thrachea, liver, heart, skin, cornea and very recently retina). A stamp is shown, which was emitted by the Japanese government to celebrate the discovery of a university team, which was able to regenerate a cornea and giving the opportunity to a patient to see again. Then the innovative results is presented in applications of the stem cells to orthopedy, muscular dystrophy, cardiology and dentistry. Finally the etherogeneus perspectives is presented offered by stem cell research to treat degenerative disorders, like Alzheimer, Parkinson diseases and Multiple Sclerosis. www ...

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World news rap – Video

February 21st, 2012 8:49 am

13-02-2012 16:06 Lyrics: I don't see how Iraq can hate from their side of the world. We're already in. My fellow Americans, leggo Red, white, and black. Flag of Iraq. Red white and blue. I pledge to the flag and you. Yeah, yeah. We just gave more rights to the gays. China gets what we get in centuries in 2 days. My country loves me. We're out of Afghanistan. We found and killed Osama in Pakistan. That girl in Somalia got rescued. Israel vs. Iran...Muslim vs. Jew Economy sucks, oh. Iran has nukes, yeah. Mitt Romney's winning. Israel's screwed, oh. Kim Jong-il died, yeah. Seal Team 6? Tough mothers. Twilight 4 just came out on DVD and it made lots of dough. Most people hate that series except for teenage girls, though. Oops, I said Twilight sucks. I ain't really mean to say Twilight sucks. Even though it kind of does, there's way more important stuff that we can discuss. Like such: Let's go! Republicans are running for the 2012 November election So far there's five left running for control of the entire nation. They'll solve the issues, see? Except the Twilight finale. I know it's either Gingrich or Romney, but Obama can still beat all four, see? In 2008 there were bets that Obama would get assassinated, but he's still alive and being president and ObamaCare's abortion policy was envied by Catholics across the globe and across America. You can bet that Barack will get another term. Rick S. is against stem cell research. And Newt won't stop at anything to make it clearer to Conservatives ...

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Stem cell therapy at VMC – Video

February 21st, 2012 8:49 am

19-12-2011 14:50 Katie Sharify, 23, of Pleasanton, receives stem cells for a spinal cord injury.

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Adult Stem Cell Treatments for COPD -Real patient results, USA Stem Cells- Donald W. Testimonial – Video

February 21st, 2012 8:49 am

20-12-2011 09:01 If you would like more information please call us Toll Free at 877-578-7908. Or visit our website at http://www.usastemcells.com Or click here to have a Free Phone Constultation with Dr. Matthew Burks usastemcells.com Real patient testimonials for USA Stem Cells. Adult stem cell therapy for COPD, Emphysema, and Pulmonary fibrosis.

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Adult Stem Cell Treatments for COPD -Real patient results, USA Stem Cells- Donald W. Testimonial - Video

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The Igwe Family – Adult Stem Cell Therapy for Sickle Cell Disease – Video

February 21st, 2012 8:49 am

15-02-2012 13:27 Hear from the family of a teenager who no longer suffers from sickle cell disease after receiving a stem cell transplant in a clinical trial NSCF funds. NSCF funds clinical trials to: • Induce drug-free tolerance for transplanted kidneys • Effectively cure inherited red blood cell disorders like sickle cell disease (SCD) and thalassemia •Permanently correct fatal childhood enzyme deficiencies For more information visit nationalstemcellfoundation.org.

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Adult Stem Cell Treatments for COPD – Real patient results, USA Stem Cells – Marian H. Testimonial – Video

February 21st, 2012 6:41 am

20-12-2011 08:50 If you would like more information please call us Toll Free at 877-578-7908. Or visit our website at http://www.usastemcells.com Or click here to have a Free Phone Constultation with Dr. Matthew Burks usastemcells.com Real patient testimonials for USA Stem Cells. Adult stem cell therapy for COPD, Emphysema, and Pulmonary fibrosis.

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Adult Stem Cell Treatments for COPD -Real patient results, USA Stem Cells- Shirlen M. Testimonial – Video

February 21st, 2012 6:41 am

11-01-2012 23:04 If you would like more information please call us Toll Free at 877-578-7908. Or visit our website at http://www.usastemcells.com Or click here to have a Free Phone Constultation with Dr. Matthew Burks usastemcells.com Real patient testimonials for USA Stem Cells. Adult stem cell therapy for COPD, Emphysema, and Pulmonary fibrosis.

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First Test-Tube Hamburger Ready This Fall

February 20th, 2012 4:52 pm

The world's first "test-tube" meat, a hamburger made from a cow's stem cells, will be produced this fall, Dutch scientist Mark Post told a major science conference on Sunday.

Post's aim is to invent an efficient way to produce skeletal muscle tissue in a laboratory that exactly mimics meat, and eventually replace the entire meat-animal industry.

PHOTOS: 10 Ways Science is Using Human-Animal Hybrids

The ingredients for his first burger are "still in a laboratory phase," he said, but by fall "we have committed ourselves to make a couple of thousand of small tissues, and then assemble them into a hamburger."

Post, chair of physiology at Maastricht University in the Netherlands, said his project is funded with 250,000 euros from an anonymous private investor motivated by "care for the environment, food for the world and interest in life-transforming technologies."

Post spoke at a symposium titled "The Next Agricultural Revolution" at the annual meeting of the American Association for the Advancement of Science in Vancouver.

Speakers said they aim to develop such "meat" products for mass consumption to reduce the environmental and health costs of conventional food production.

Conventional meat and dairy production requires more land, water, plants and disposal of waste products than almost all other human foods, they said.

The global demand for meat is expected to rise by 60 percent by 2050, said American scientist Nicholas Genovese, who organized the symposium.

"But the majority of earth's pasture lands are already in use," he said, so conventional livestock producers can only meet the booming demand by further expansion into nature.

The result would be lost biodiversity, more greenhouse and other gases, and an increase in disease, he said.

In 2010 a report by the United Nations Environment Program called for a global vegetarian diet.

BLOG: Play With Your 3D Printed Food

"Animal farming is by far the biggest ongoing global catastrophe," Patrick Brown of the Stanford University School of Medicine told reporters.

"More to the point, it's incredibly ready to topple ... it's inefficient technology that hasn't changed fundamentally for millennia," he said.

"There's been a blind spot in the science and technology community (of livestock production) as an easy target."

Brown, who said he is funded by an American venture capital firm and has two start-ups in California, said he will devote the rest of his life to develop products that mimic meat but are made entirely from vegetable sources.

He is working "to develop and commercialize a product that can compete head on with meat and dairy products based on taste and value for the mainstream consumer, for people who are hard-core meat and cheese lovers who can't imagine ever giving that up, but could be persuaded if they had a product with all taste and value."

Brown said developing meat from animal cells in a laboratory will still have a high environmental cost, and so he said he will rely only on plant sources.

Both scientists said no companies in the existing meat industry have expressed interest.

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Russian Press – Behind the Headlines, February 20

February 20th, 2012 4:52 pm

Moskovskiye Novosti

Church Calls for Ban on Stem Cell Research

The Russian Orthodox Church has called for recognizing fetuses as human life and for banning medical research that involves biological material procured from abortion procedures.

The church has sent a series of amendments to the cell technology bill, which iscurrently in the works, to Healthcare Minister Tatyana Golikova in the hope that “the ministry will heed its opinion.” “We, in turn, are ready for dialogue and discussion on each proposal,” said Bishop Panteleimon, head of the the Synodal Department for Church Charity and Social Ministry.

Incidentally, the clerics cite “enlightened” European policies on this issue. In October 2011, the European Court of Justice outlawed the patenting of stem cell research that destroys a human embryo as immoral. Russia’s Healthcare Ministry supported that decision and said the cell technology bill they were working on embraced similar ethical principles. Deputy Minister Veronika Skvortsova said the new bill would ban the use of a human fetus, embryo or gamete in preparing cell lines.

According to Father Panteleimon, this means that the government is ready to agree that a fertilized ovum constitutes a person. Therefore, it would only remain to legalize this statement. That would make it possible to refer to an embryo as a “child,” which in turn would make the 1959 Children’s Rights declaration applicable to the embryo, thus guaranteeing the “child” legal protection “before and after birth.”

One proposal would include church officials on the ministry’s expert council on biomedical ethics. The church has had a similar council since 1998.

“The ministry’s bill cites advanced cell technology that is not widely used in Russia,” a church official said. “At the same time, there are simpler technologies which also use fetal cells as biological material, and these are quite widespread.”

The letter sent to Minister Golikova mentions valid patents for using fetal cells in anti-aging treatments, mesotherapy and fetal tissue implants.

The bill, drafted by the Ministry of Healthcare, is currently in the public discussion stage, and could be submitted to the lower house this spring. Given current legislative trends, the church may well expect that its proposals will be heeded. However, Russian scientists involved in stem cell research fear that the bill would entirely halt research in this area.

According to Sergei Kiselyov from the Human Stem Cells Institute, very few cell technologies are actually used in medicine. The bill would drastically limit the current research and could affect projects that are already underway. This would lead to Russia’s lagging even further behind Western biotechnology, he said.

Kommersant

Russia Joins OECD Convention Against Bribery

The Russian Foreign Ministry notified the Organization for Economic Cooperation and Development (OECD) on Friday that Russia has joined the OECD Convention on Combating Bribery of Foreign Public Officials in International Business Transactions. Experts believe that joining the convention will stimulate the fight against corruption. Russia will be the 39th state party to the convention as of April 17.

The State Duma ratified the convention on January 13, 2012, and President Dmitry Medvedev signed it into law on February 1. Medvedev said at a judiciary meeting, “Accession will harmonize our legal system with international standards in the fight against corruption.”

“We have not joined this convention to please anybody,” First Deputy Foreign Minister Andrei Denisov clarified. “Joining is important in terms of our internal anti-corruption policy.”

Denisov added that ratifying the convention, a three-year process, is a condition for OECD accession. Russia, he said, will seek to join the organization in 2013, but the country will have to ratify 160 other conventions and instruments in 22 categories, including the introduction of international standards for economic statistics. Joining the anti-bribery convention requires Russia to pay annual dues of about 100,000 euros per year to the OECD Working Group on Bribery in International Business.

The convention was signed in 1997 and entered into force in February 1999. Most European countries are members, as are some Latin American countries and the United States. The main obligation for the states parties is to track and prosecute their citizens for bribery or attempted bribery of foreign officials and to track foreign officials on their territories who take bribes. The convention recommends not only criminalizing these acts, but also blacklisting the companies found guilty of bribing foreign public officials from tenders for government contracts. The convention discourages the practice of allowing income tax deductions for bribes to officials of foreign states: some companies in developing countries having been implicated in this practice. The convention aims to prevent parties from adding to corruption not only within their borders, but also beyond. However, fewer than 20% of participating countries actively apply the convention's provisions, according to a 2011 Transparency International report.

Even before ratifying the convention, Russia adopted a series of measures to fulfill it. In April 2011, Dmitry Medvedev's anti-corruption package introduced amendments to the Criminal Code, including multiple penalties for giving and receiving bribes, as well as mediation. Foreign officials as well as companies that give bribes to foreign officials or officials of international public organizations will be held liable.

Vladimir Yuzhakov, director of the Department for Administrative Reform at the Center for Strategic Studies, said that the practice of applying the convention will provide additional incentives to fight corruption in the country in general. Yuzhakov expects that the convention will require further steps in developing anti-corruption legislation – in particular, the introduction of more stringent procedures for investigating cases of bribery of foreign public officials.

RIA Novosti is not responsible for the content of outside sources.

 

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Russian Press - Behind the Headlines, February 20

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At $290,000 test-tube burger is a taste of what's to come

February 20th, 2012 4:50 pm

Would you like fries with that? British celebrity chef Heston Blumenthal could be flipping test-tube burgers.

LURKING in a petri dish in a laboratory in the Netherlands is an unlikely contender for the future of food. The yellow-pink sliver is state-of-the-art in lab-grown meat and a milestone on the path to the world's first burger made from stem cells.

Dr Mark Post, the head of physiology at Maastricht University, plans to unveil a complete burger - produced at a cost of more than $290,000 - this October.

He hopes Heston Blumenthal, the chef and owner of the three Michelin-starred Fat Duck restaurant in Berkshire, southern England, will cook the offering for a celebrity taster.

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A new meaning to instant meals ... food in a test-tube.

The project, funded by a wealthy, anonymous, individual, aims to slash the number of cattle farmed for food and reduce one of the major contributors to greenhouse gas emissions.

''Meat demand is going to double in the next 40 years and right now we are using 70 per cent of all our agricultural capacity to grow meat through livestock,'' Dr Post said.

''You can easily calculate that we need alternatives. If you don't do anything meat will become a luxury food and be very, very expensive.''

Livestock contribute to global warming through unchecked releases of methane, a gas 20 times more potent than carbon dioxide.

At the American Association for the Advancement of Science meeting in Vancouver, Dr Post said the burger would be a ''proof of concept'' to demonstrate that ''with in-vitro methods, out of stem cells we can make a product that looks like and feels and hopefully tastes like meat.''

Dr Post is focusing on making beef burgers from stem cells because cows are among the least efficient animals at converting the food they eat into food for humans.

Dr Post and his team have so far grown thin sheets of cow muscle measuring 3 centimetres long, 1.5 centimetres wide and half a millimetre thick. To make a burger will take 3000 pieces of muscle and a few hundred pieces of fatty tissue, that will be minced together and pressed into a patty.

Each piece of muscle is made by extracting stem cells from cow muscle tissue and growing them in containers. The cells are grown in a culture medium containing foetal calf serum, which contains scores of nutrients the cells need to grow.

Guardian News & Media

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Evidence Discovered To Support Turing's Morphogen Theory

February 20th, 2012 4:50 pm

February 20, 2012

A team of UK researchers claims to have put forth the first ever experimental evidence in support of a long-standing theory about how biological patterns such as a leopard’s spots or a tiger’s stripes are formed.

The study was the work of experts from King’s College London, and according to a February 19 press release from the school, “The findings provide evidence to support a theory first suggested in the 1950s by famous code-breaker and mathematician Alan Turing,” who championed the idea that “regular repeating patterns in biological systems are generated by a pair of morphogens that work together as an ‘activator’ and ‘inhibitor’.”

Their work “not only demonstrates a mechanism which is likely to be widely relevant in vertebrate development, but also provides confidence that chemicals called morphogens, which control these patterns, can be used in regenerative medicine to differentiate stem cells into tissue,” the college added.

In order to test their theory, the King’s College London researchers analyzed the development of regularly-spaced ridges that can be found in the mouths of mice.

By conducting experiments using embryos of the rodents, they were able to discover the pair of morphogens that work together to help determine where each of the ridges will be formed. Each chemical influenced the other, the university said, alternately activating or inhibiting production in order to control the creation of the ridge pattern on the roof of a mouse’s mouth.

The morphogens involved in the process were identified by the scientists as Fibroblast Growth Factor (FGF) and Sonic Hedgehog (Shh), and by studying them, they learned that when each chemical’s activity is increased or decreased, it affected the pattern of the ridges in the mouth in the same way that Turing’s equations had predicted they would.

“For the first time the actual morphogens involved in this process have been identified and the team were able to see exactly the effects predicted by Turing’s 60-year-old speculative theory,” the college press release stated.

“Regularly spaced structures, from vertebrae and hair follicles to the stripes on a tiger or zebrafish, are a fundamental motif in biology. There are several theories about how patterns in nature are formed, but until now there was only circumstantial evidence for Turing’s mechanism. Our study provides the first experimental identification of an activator-inhibitor system at work in the generation of stripes – in this case, in the ridges of the mouth palate,” Dr. Jeremy Green from the Department of Craniofacial Development at King’s Dental Institute added in a statement.

While Green admitted that the discovery was “not of great medical significance,” he said that they are “extremely valuable” in validating Turing’s theories from the 1950s. He also says that their discovery has made them confident that these morphogen chemicals could be used in the future to create regenerative medicine to heal or recreate structures and/or patterns when turning stem cells into other types of tissues.

The research was funded by the Medical Research Council and is published online in the journal Nature Genetics.

Turing, who was born on June 23, 1912 and would have turned 100 this year, has been referred to by some as the father of computer science and artificial intelligence. During World War II, he served as a member of the Government Code and Cypher School (GCCS) at Bletchley Park in the field of naval cryptanalysis.

Turing later went on to join the National Physical Laboratory, where he created one of the very first stored-program computer designs, in 1948 he assisted in the development of computers at Manchester University. His paper “The Chemical Basis of Morphogenesis,” in which he first put forth his theory of pattern formation, was published by Philosophical Transactions of the Royal Society of London in August 1952.

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LifeNet Health is Presenting at the 7th Annual Stem Cell Summit in New York on February 21, 2012

February 20th, 2012 4:50 pm

To: HEALTH AND NATIONAL EDITORS

VIRGINIA BEACH, Va., Feb. 20, 2012 /PRNewswire-USNewswire/ -- Rony Thomas, President and CEO of LifeNet Health, is presenting at the 7th Annual Stem Cell Summit in New York City on February 21, 2012. Mr. Thomas will be presenting on LifeNet Health's broad offerings of current and future regenerative biologic-based products. Mr. Thomas will also focus on the multiple new capabilities and technology platforms of the LifeNet Health Institute of Regenerative Medicine.

(Photo: http://photos.prnewswire.com/prnh/20120220/DC55479)

"The use of a variety of forms of donated tissues has worked for decades to save lives and restore health in many surgical disciplines. Now we are on the cusp of developing cellular therapies, tissue engineering and new medical applications for allografts to treat disease and assist in the development of lifesaving drugs. The opening of the LifeNet Health Institute of Regenerative Medicine this year will signal our commitment to future development in the cellular therapies arena," stated Mr. Thomas. Thomas will further focus on two new areas of development; Human Basement Membranes in zeno-free culture of consented Human mRNA Reprogrammed Induced Pluripotent Stem Cells and Induced Pluripotent Stem Cells (iPSc) derived using non-integrating mRNA reprogramming technology from fully consented queryable human donor banked system.

Mr. Thomas was also recently invited to and attended a White House Summit to discuss ways in which technology and innovation can drive employment opportunities for Virginia, where LifeNet Health and the Institute are located. The meeting of key CEOs with the Obama Administration was to gain insight and input on the job market and technology as a driver to local, state, and national economies. Thomas stated, "Our foray into regenerative medicine should not only impact our state and local economy, but provide medical benefits to patients and drug companies across the globe."

The annual Stem Cell Summit brings key leaders in the medical, scientific and business innovators in this growing space of technology and regenerative medicine. LifeNet Health is pleased to be joining the Summit for the first time in 2012 as they look for key partnerships and collaboration in the discovery of cell-based therapies for a broad spectrum of medical applications in orthopedics, trauma, dental, craniomaxillofacial (CMF), plastics, and cardiovascular surgery.

LifeNet Health helps to save lives and restore health for thousands of patients each year. We are the world's most trusted provider of transplant solutions, from organ procurement to new innovations in bio-implant technologies and cellular therapies--a leader in the field of regenerative medicine, while always honoring the donors and healthcare professionals that allow the healing process.

The LifeNet Health Institute of Regenerative Medicine is a division of LifeNet Health located in Virginia Beach, Virginia. The Institute's labs will be expanding as new facilities are under construction and planned to be completed in the fall of 2012. Once completed and fully functional, the Institute will house over 50 medical, scientific, and research staff members. The focus will be on the science of developing regenerative medicine products for patients all over the world, and will serve as a global center of excellence for research and development focused on cellular therapies, tissue engineering, and new medical applications for allografts to maximize the gift of donation.

SOURCE LifeNet Health

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LifeNet Health is Presenting at the 7th Annual Stem Cell Summit in New York on February 21, 2012

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First test-tube hamburger ready this fall: researchers

February 20th, 2012 6:57 am

The world's first "test-tube" meat, a hamburger made from a cow's stem cells, will be produced this fall, Dutch scientist Mark Post told a major science conference on Sunday.

Post's aim is to invent an efficient way to produce skeletal muscle tissue in a laboratory that exactly mimics meat, and eventually replace the entire meat-animal industry.

The ingredients for his first burger are "still in a laboratory phase," he said, but by fall "we have committed ourselves to make a couple of thousand of small tissues, and then assemble them into a hamburger."

Post, chair of physiology at Maastricht University in the Netherlands, said his project is funded with 250,000 euros from an anonymous private investor motivated by "care for the environment, food for the world, and interest in life-transforming technologies."

Post spoke at a symposium titled "The Next Agricultural Revolution" at the annual meeting of the American Association for the Advancement of Science in Vancouver.

Speakers said they aim to develop such "meat" products for mass consumption to reduce the environmental and health costs of conventional food production.

Conventional meat and dairy production requires more land, water, plants and disposal of waste products than almost all other human foods, they said.

The global demand for meat is expected to rise by 60 percent by 2050, said American scientist Nicholas Genovese, who organized the symposium.

"But the majority of earth's pasture lands are already in use," he said, so conventional livestock producers can only meet the booming demand by further expansion into nature.

The result would be lost biodiversity, more greenhouse and other gases, and an increase in disease, he said.

In 2010 a report by the United Nations Environment Program called for a global vegetarian diet.

"Animal farming is by far the biggest ongoing global catastrophe," Patrick Brown of the Stanford University School of Medicine told reporters.

"More to the point, it's incredibly ready to topple ... it's inefficient technology that hasn't changed fundamentally for millennia," he said.

"There's been a blind spot in the science and technology community (of livestock production) as an easy target."

Brown, who said he is funded by an American venture capital firm and has two start-ups in California, said he will devote the rest of his life to develop products that mimic meat but are made entirely from vegetable sources.

He is working "to develop and commercialize a product that can compete head on with meat and dairy products based on taste and value for the mainstream consumer, for people who are hard-core meat and cheese lovers who can't imagine ever giving that up, but could be persuaded if they had a product with all taste and value."

Brown said developing meat from animal cells in a laboratory will still have a high environmental cost, and so he said he will rely only on plant sources.

Both scientists said no companies in the existing meat industry have expressed interest.

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First test-tube hamburger ready this fall: researchers

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Turing's 'Tiger stripes' theory proved right

February 20th, 2012 6:55 am

London, Feb 20 (ANI): Providing the first experimental evidence, King's College London scientists have confirmed a great British mathematician's theory of how biological patterns, such as tiger stripes or leopard spots, are formed.

Their study not only demonstrates a mechanism, which is likely to be widely relevant in vertebrate development, but also provides confidence that chemicals called morphogens, which control these patterns, can be used in regenerative medicine to differentiate stem cells into tissue.

The findings provide evidence to support a theory first suggested in the 1950s by famous code-breaker and mathematician Alan Turing, whose centenary falls this year.

He put forward the idea that regular repeating patterns in biological systems are generated by a pair of morphogens that work together as an 'activator' and 'inhibitor'.

To test the theory the researchers studied the development of the regularly spaced ridges found in the roof of the mouth in mice. Carrying out experiments in mouse embryos, the team identified the pair of morphogens working together to influence where each ridge will be formed.

These chemicals controlled each other's expression, activating and inhibiting production and therefore controlling the generation of the ridge pattern.

The researchers were able to identify the specific morphogens involved in this process - FGF (Fibroblast Growth Factor) and Shh (Sonic Hedgehog - so-called because laboratory fruit flies lacking the fly version have extra bristles on their bodies).

They showed that when these morphogens' activity is increased or decreased, the pattern of the ridges in the mouth palate are affected in ways predicted by Turing's equations.

For the first time the actual morphogens involved in this process have been identified and the team were able to see exactly the effects predicted by Turing's 60-year-old speculative theory.

"Regularly spaced structures, from vertebrae and hair follicles to the stripes on a tiger or zebrafish, are a fundamental motif in biology. There are several theories about how patterns in nature are formed, but until now there was only circumstantial evidence for Turing's mechanism," said Dr Jeremy Green from the Department of Craniofacial Development at King's Dental Institute.

"Our study provides the first experimental identification of an activator-inhibitor system at work in the generation of stripes - in this case, in the ridges of the mouth palate.

"Although important in feeling and tasting food, ridges in the mouth are not of great medical significance. However, they have proven extremely valuable here in validating an old theory of the activator-inhibitor model first put forward by Alan Turing in the 50s.

"Not only does this show us how patterns such as stripes are formed, but it provides confidence that these morphogens (chemicals) can be used in future regenerative medicine to regenerate structure and pattern when differentiating stem cells into other tissues.

"As this year marks Turing's centenary, it is a fitting tribute to this great mathematician and computer scientist that we should now be able to prove that his theory was right all along!" Dr Green added.

The study will be published online in Nature Genetics. (ANI)

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Test tube burgers could hit kitchens this year after scientists create meat with taste of quarter-pounder

February 19th, 2012 10:46 pm

Prototype burger will cost ?220,000 to produce

By Fiona Macrae Science Correspondent

Last updated at 10:16 PM on 19th February 2012

The world’s first test-tube burger will be ready to eat within months.

It will look, feel and, it is hoped, taste, like a regular quarter-pounder, its creator Mark Post told the world’s premier science conference.

He plans to unveil the hamburger in October - and hopes celebrity chef Heston Blumenthal will cook it, although he has yet to approach him.

Tasty: A small sample of the lab-grown 'meat' which Dutch stem cell scientist Dr Mark Post believes everyone will want to eat

The ‘ethical meat’ will would be kinder to the environment than the real thing, reduce animal suffering and help feed the world’s burgeoning population.

 

But it will be far from cheap with the prototype burger costing ?220,000 to produce.

Professor Post says that ‘everyone’ will want to eat the burgers, which, despite their vast initial cost could eventually be priced to match that of real meat.

However, it remains to be seen whether a public that likes to think of its chops, steaks and sausages as having their roots in nature will take to meat made in test-tubes.

The Maastricht Univeristy professor has spent the last six years trying to turn stem cells - ‘master cells’ with the power to turn into all other cell types - into meat.

Real thing: But the new meat  could be an ethical alternative to beef

He first attempts involved mouse burgers. He then tried to grow pork in a dish, producing strips with the rubbery texture of squid or scallops, before settling on beef.

A four-step technique is used to turn stem cells from animal flesh into a burger.

First, the stem cells are stripped from the cow’s muscle.

Next, they are incubated in a nutrient broth until they multiply many times over, creating a sticky tissue with the consistency of an undercooked egg.

This ‘wasted muscle’ is then bulked up through the laboratory equivalent of exercise - it is anchored to Velcro and stretched.

Finally, 3,000 strips of the lab-grown meat are minced, and, along with 200 pieces of lab-grown animal fat, formed into a burger.

The process is still lengthy, as well as expensive, but optimised, it could take just six weeks from stem cell to supermarket shelf.

Yesterday, Professor Post told the American Association for the Advancement of Science’s annual conference in Vancouver that he has so far made a strip of beef measuring 3cm by 1.5cm by 0.5cm.

This beef is ‘pinkish to yellow’ in colour - but he is confident of having a full-sized and properly coloured burger by the autumn.

The professor, who is funded by an anonymous but highly-successful benefactor, said: ‘It’s not quite ready, it’s going to be presented in October.

‘We are going to provide a proof of concept, showing that out of stem cells you can produce a product that looks like and feels like and hopefully tastes like meat.

‘Seeing and tasting is believing.’ Sausages and other processed meat products could swiftly follow, although pork chops and sirloin steaks will be much more problematic.

Other possibilities include synthetic versions of the meat from are animals such as pandas and tigers.

Meats could also be made extra-healthy by boosting their content of ‘good’ fats.

Far fewer animals would have to be kept to satisfy the appetite for meat.

The stem cell’s extraordinary ability to grow and multiply means that a cells taken from a single cow could produce a million times more burgers than if the animal was slaughtered for meat.

Choice: Professor Post hopes experimental chef Heston Blumenthal will have a go at cooking his new invention

Researchers say they realise that many will find the idea of eating lab-grown meat unnatural - but point out that the livestock eaten at the moment is often kept in cramped conditions and dosed with chemicals or antibiotics.

However, the fact that the source material comes from animals who will likely have slaughtered means that not all vegetarians will be happy with the product.

The fledgling technology was highlighted in discussion paper about current and future demands on livestock production published recently by the Royal Society, Britain’s most prestigious scientific body.

The paper’s author, Professor Philip Thornton, of the International Livestock Research Institute in Edinburgh, wrote: ‘This is one example of something that could happen in the future that could have a very big impact on agriculture and livestock production.

‘There are some advantages to the idea. For example, you could reduce the number of live animals substantially and that would reduce greenhouse gas production.

‘There might be human health benefits because the health and safety issues associated with meat could be much better controlled.

‘But are people going to eat it? People’s tastes have changed a lot over the years and eventually this may be something that is widely taken up.’

Cautioning about the economic impact on farmers, the professor said: ‘If you are talking about large-scale reductions in numbers of livestock, there are large-scale implications and we’d have to look very carefully to see if the benefits would outweigh some of the problems that might arise.’

It will be at least ten years before the artificial meat is produced on an industrial scale and has satisfied the safety testing necessary for it be placed on supermarket shelves.

 

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Test tube burgers could hit kitchens this year after scientists create meat with taste of quarter-pounder

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Alan Turing's 1950s tiger stripe theory proved

February 19th, 2012 10:46 pm

The study, funded by the Medical Research Council and to be published online in Nature Genetics, not only demonstrates a mechanism which is likely to be widely relevant in vertebrate development, but also provides confidence that chemicals called morphogens, which control these patterns, can be used in regenerative medicine to differentiate stem cells into tissue.

The findings provide evidence to support a theory first suggested in the 1950s by famous code-breaker and mathematician Alan Turing, whose centenary falls this year. He put forward the idea that regular repeating patterns in biological systems are generated by a pair of morphogens that work together as an 'activator' and 'inhibitor'.

To test the theory the researchers studied the development of the regularly spaced ridges found in the roof of the mouth in mice. Carrying out experiments in mouse embryos, the team identified the pair of morphogens working together to influence where each ridge will be formed. These chemicals controlled each other's expression, activating and inhibiting production and therefore controlling the generation of the ridge pattern.

The researchers were able to identify the specific morphogens involved in this process – FGF (Fibroblast Growth Factor) and Shh (Sonic Hedgehog – so-called because laboratory fruit flies lacking the fly version have extra bristles on their bodies). They showed that when these morphogens' activity is increased or decreased, the pattern of the ridges in the mouth palate are affected in ways predicted by Turing's equations. For the first time the actual morphogens involved in this process have been identified and the team were able to see exactly the effects predicted by Turing's 60-year-old speculative theory.

Dr Jeremy Green from the Department of Craniofacial Development at King's Dental Institute said: 'Regularly spaced structures, from vertebrae and hair follicles to the stripes on a tiger or zebrafish, are a fundamental motif in biology. There are several theories about how patterns in nature are formed, but until now there was only circumstantial evidence for Turing's mechanism. Our study provides the first experimental identification of an activator-inhibitor system at work in the generation of stripes – in this case, in the ridges of the mouth palate.

'Although important in feeling and tasting food, ridges in the mouth are not of great medical significance. However, they have proven extremely valuable here in validating an old theory of the activator-inhibitor model first put forward by Alan Turing in the 50s.

'Not only does this show us how patterns such as stripes are formed, but it provides confidence that these morphogens (chemicals) can be used in future regenerative medicine to regenerate structure and pattern when differentiating stem cells into other tissues.

'As this year marks Turing's centenary, it is a fitting tribute to this great mathematician and computer scientist that we should now be able to prove that his theory was right all along!'

Provided by King's College London (news : web)

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Alan Turing's 1950s tiger stripe theory proved

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Scientists prove Turing's tiger stripe theory

February 19th, 2012 10:46 pm

Public release date: 19-Feb-2012
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Contact: Katherine Barnes
katherine.barnes@kcl.ac.uk
44-020-784-83076
King's College London

Researchers from King's College London have provided the first experimental evidence confirming a great British mathematician's theory of how biological patterns such as tiger stripes or leopard spots are formed.

The study, funded by the Medical Research Council and to be published online in Nature Genetics, not only demonstrates a mechanism which is likely to be widely relevant in vertebrate development, but also provides confidence that chemicals called morphogens, which control these patterns, can be used in regenerative medicine to differentiate stem cells into tissue.

The findings provide evidence to support a theory first suggested in the 1950s by famous code-breaker and mathematician Alan Turing, whose centenary falls this year. He put forward the idea that regular repeating patterns in biological systems are generated by a pair of morphogens that work together as an 'activator' and 'inhibitor'.

To test the theory the researchers studied the development of the regularly spaced ridges found in the roof of the mouth in mice. Carrying out experiments in mouse embryos, the team identified the pair of morphogens working together to influence where each ridge will be formed. These chemicals controlled each other's expression, activating and inhibiting production and therefore controlling the generation of the ridge pattern.

The researchers were able to identify the specific morphogens involved in this process ? FGF (Fibroblast Growth Factor) and Shh (Sonic Hedgehog ? so-called because laboratory fruit flies lacking the fly version have extra bristles on their bodies). They showed that when these morphogens' activity is increased or decreased, the pattern of the ridges in the mouth palate are affected in ways predicted by Turing's equations. For the first time the actual morphogens involved in this process have been identified and the team were able to see exactly the effects predicted by Turing's 60-year-old speculative theory.

Dr Jeremy Green from the Department of Craniofacial Development at King's Dental Institute said: 'Regularly spaced structures, from vertebrae and hair follicles to the stripes on a tiger or zebrafish, are a fundamental motif in biology. There are several theories about how patterns in nature are formed, but until now there was only circumstantial evidence for Turing's mechanism. Our study provides the first experimental identification of an activator-inhibitor system at work in the generation of stripes ? in this case, in the ridges of the mouth palate.

'Although important in feeling and tasting food, ridges in the mouth are not of great medical significance. However, they have proven extremely valuable here in validating an old theory of the activator-inhibitor model first put forward by Alan Turing in the 50s.

'Not only does this show us how patterns such as stripes are formed, but it provides confidence that these morphogens (chemicals) can be used in future regenerative medicine to regenerate structure and pattern when differentiating stem cells into other tissues.

'As this year marks Turing's centenary, it is a fitting tribute to this great mathematician and computer scientist that we should now be able to prove that his theory was right all along!'

###

CONTACT
Katherine Barnes
International Press Officer
King's College London
Tel: 44-207-848-3076
Email: katherine.barnes@kcl.ac.uk

NOTES TO EDITORS

Copies of the paper available on request ? please contact press@nature.com

About King's College London (www.kcl.ac.uk)

King's College London is one of the top 30 universities in the world (2011/12 QS World University Rankings), and the fourth oldest in England. A research-led university based in the heart of London, King's has nearly 23,500 students (of whom more than 9,000 are graduate students) from nearly 140 countries, and some 6,000 employees. King's is in the second phase of a ?1 billion redevelopment programme which is transforming its estate.

King's has an outstanding reputation for providing world-class teaching and cutting-edge research. In the 2008 Research Assessment Exercise for British universities, 23 departments were ranked in the top quartile of British universities; over half of our academic staff work in departments that are in the top 10 per cent in the UK in their field and can thus be classed as world leading. The College is in the top seven UK universities for research earnings and has an overall annual income of nearly ?450 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar. It is the largest centre for the education of healthcare professionals in Europe; no university has more Medical Research Council Centres.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: http://www.kingshealthpartners.org.

The College is in the midst of a five-year, ?500 million fundraising campaign ? World questions|King's answers ? created to address some of the most pressing challenges facing humanity as quickly as feasible. The campaign's three priority areas are neuroscience and mental health, leadership and society, and cancer. More information about the campaign is available at http://www.kcl.ac.uk/kingsanswers.

About Medical Research Council (http://www.mrc.ac.uk)

For almost 100 years the Medical Research Council has improved the health of people in the UK and around the world by supporting the highest quality science. The MRC invests in world-class scientists. It has produced 29 Nobel Prize winners and sustains a flourishing environment for internationally recognised research. The MRC focuses on making an impact and provides the financial muscle and scientific expertise behind medical breakthroughs, including one of the first antibiotics penicillin, the structure of DNA and the lethal link between smoking and cancer. Today MRC funded scientists tackle research into the major health challenges of the 21st century.


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Scientists prove Turing's tiger stripe theory

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Dijaya boss in healthcare venture

February 19th, 2012 10:46 pm

TAN Sri Danny Tan Chee Sing, who controls Dijaya Group, has ventured into the healthcare business, following in the footsteps of elder brother Tan Sri Vincent Tan Chee Yioun.

The younger Tan is partnering several doctors to operate the Beverly Wilshire Medical Centre Sdn Bhd, to capture a piece of the booming aesthetic industry here.

"Beverly Wilshire is a boutique medical centre specialising in aesthetics, plastic, stem cell therapy and health screening," its executive director Dr Liow Tiong Sin told Business Times in a recent interview.

This 13-bed hospital also has a dental unit, operated by Beverly Wilshire Dental Specialist Centre Sdn Bhd, which has Tan as a common shareholder.

In total, the facility will have six medical doctors - including two surgeons, four physicians and five dental surgeons.

"This is a centre that provides total transformation for the patient. We provide a high standard of service, individual service that ensures patients don't feel like hospital patients but rather a place for healing and rejuvenation," Dr Liow, who is also the aesthetic physician, said.

It is also a one-stop centre for transformation and healthy aging, providing both external and internal treatment.

All its equipment are FDA approved. Its machines include Fraxel for scar, pigment and skin rejuvenation and Thermage CPT, which is used to firm skin, improve cellulite, body tightening and sculpting.

How is this centre different from other beauty centres and medical centres providing similar services?

"Others may not be focused and built to specialise on aesthetics. We trust we are the only one-stop place which offers treatment from plastic (surgery) to anti-aging, to stem cell to dental," he said.

Beverly Wilshire uses human stem cells as it is the most bio-compatible. At the same time, stem cells can also be harvested in the purest form from a person's fat cell for an autologous transplant.

Stem cell therapy is used to regenerate the muscle and vessels in the heart and in the brain to regenerate the nerves and improve blood supply.

While most hospitals in Malaysia would typically take about 10 years to see return on investments (ROI), Beverly Wilshire expects to see ROI in less than half that time or less. Its expected investment cost is some RM20 million.

"This is a boutique type centre. ROI could take three to five years," he said.

Beverly Wilshire, started as a privately held Dijaya Medical Centre but decided to change its name as the name Dijaya is closely linked to property.

Since it is a beauty and aesthetics centre, it searched for names and settled with Beverly Wilshire as it was a luxury hotel in Beverly Hills in the US.

"So we thought we will create the Hollywood theme and provide the best," Dr Liow said.

This 13-bed hospital is located at Plaza Dijaya in Jalan Tun Razak, Kuala Lumpur. It will be launched soon.

It will target both locals and foreigners. For some foreign patients, the treatment will be a fraction of the cost compared to the same treatment in their country.

Continued here:
Dijaya boss in healthcare venture

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