StemCell Therapy

CLEARWATER, FL--(Marketwire -08/07/12)- Biostem U.S., Corporation (HAIR) (HAIR) (Biostem, the Company), a fully reporting public company in the stem cell regenerative medicine sciences sector, announced the appointment of Marina Pizarro, M.D. to its Scientific and Medical Board of Advisors (SAMBA). Chief Executive Officer Dwight Brunoehler stated, "The addition of Dr. Pizarro to Scientific and Medical Board of Advisors rounds out our team with expertise in the field of hair re-growth using stem cells. We look forward to her interaction with the members to help advance the Company's mission to improve the quality and longevity of life for all mankind through the use of ethically sourced stem cells."

Dr. Pizarro is currently the Medical Director for Biostem U.S. as well as their trainer for the Company's hair re-growth Affiliate Program. As the company accepts qualified affiliate physicians to administer The Biostem Method of hair re-growth throughout the United States, Dr. Pizarro will oversee their training at her Orlando, Florida location, where she is currently accepting patients. Dr. Pizarro will begin offering the Biostem Method in her Tampa and Jacksonville, Florida offices in the coming months. She will also assist in overseeing the set-up of another training facility overseas as the company expands its Medical Affiliate Program internationally.

Dr. Marina Pizarro holds the distinction of being the first female hair transplant physician in the industry and belongs to the elite group of surgeons who have performed over 30,000 hair transplant procedures in their careers. She received her medical degree from Ponce School of Medicine in Puerto Rico in 1985. After completing her residency in Orlando, Dr. Pizarro worked with world renowned hair transplant surgeon Dr. Constantine Chambers building one of the largest hair restoration practices in history. After five years, and after having performed thousands of procedures around the world while lecturing at hair restoration conventions, Dr. Pizarro opened her first two facilities in Orlando and Jacksonville, Florida in 1994, specializing in hair transplantation for both men and women. She currently has three facilities in Florida with the addition of her clinic in Tampa. Dr. Pizarro is a member of The International Society of Hair Restoration Surgery and the European Society of Hair Restoration Surgery.

About Biostem U.S. Corporation

Biostem U.S., Corporation (HAIR) (HAIR) is a fully reporting Nevada corporation with offices in Clearwater, Florida. Biostem U.S. is a technology licensing company with proprietary technology centered on providing hair re-growth using human stem cells. The company also intends to train and license selected physicians to provide Regenerative Cellular Therapy treatments to assist the body's natural approach to healing tendons, ligaments, joints and muscle injuries by using the patient's own stem cells. Biostem U.S. is seeking to expand its operations worldwide through licensing of its proprietary technology and acquisition of existing stem cell related facilities. The company's goal is to operate in the international biotech market, focusing on the rapidly growing regenerative medicine field, using ethically sourced adult stem cells to improve the quality and longevity of life for all mankind.

The company's Board of Directors is headed by Chairman, Scott Crutchfield, who also acts as Senior Vice President of World Wide Operations for Crocs, Inc. (CROX) and includes Crocs, Inc. original member, Steve Beck.

More information on Biostem U.S., Corporation can be obtained through http://www.biostemus.com or by contacting Fox Communications Group at 310-974-6821.

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Biostem U.S., Corporation Appoints Marina Pizarro, M.D. to Scientific and Medical Board of Advisors (SAMBA)

--Studies in mice reveal how mood-altering drugs may affect brain stem cells

Newswise Working with mice, Johns Hopkins researchers say they have figured out how stem cells found in a part of the brain responsible for learning, memory and mood regulation decide to remain dormant or create new brain cells. Apparently, the stem cells listen in on the chemical communication among nearby neurons to get an idea about what is stressing the system and when they need to act.

The researchers say understanding this process of chemical signaling may shed light on how the brain reacts to its environment and how current antidepressants work, because in animals these drugs have been shown to increase the number of brain cells. The findings are reported July 29 in the advance online publication of Nature.

What we learned is that brain stem cells dont communicate in the official way that neurons do, through synapses or by directly signaling each other, says Hongjun Song, Ph.D., professor of neurology and director of Johns Hopkins Medicines Institute for Cell Engineerings Stem Cell Program. Synapses, like cell phones, allow nerve cells to talk with each other. Stem cells dont have synapses, but our experiments show they indirectly hear the neurons talking to each other; its like listening to someone near you talking on a phone.

The indirect talk that the stem cells detect is comprised of chemical messaging fueled by the output of neurotransmitters that leak from neuronal synapses, the structures at the ends of brain cells that facilitate communication. These neurotransmitters, released from one neuron and detected by a another one, trigger receiving neurons to change their electrical charges, which either causes the neuron to fire off an electrical pulse propagating communication or to settle down, squelching further messages.

To find out which neurotransmitter brain stem cells can detect, the researchers took mouse brain tissue, attached electrodes to the stem cells and measured any change in electrical charge after the addition of certain neurotransmitters. When they treated the stem cells with the neurotransmitter GABA a known signal-inhibiting product the stem cells electrical charges changed, suggesting that the stem cells can detect GABA messages.

To find out what message GABA imparts to brain stem cells, the scientists used a genetic trick to remove the gene for the GABA receptor the protein on the surface of the cell that detects GABA only from the brain stem cells. Microscopic observation of brain stem cells lacking the GABA receptor over five days showed these cells replicated themselves, or produced glial cells support cells for the neurons in the brain. Brain stem cells with their GABA receptors intact appeared to stay the same, not making more cells.

Next, the team treated normal mice with valium, often used as an anti-anxiety drug and known to act like GABA by activating GABA receptors when it comes in contact with them. The scientists checked the mice on the second and seventh day of valium use and counted the number of brain stem cells in untreated mice and mice treated with the GABA activator. They found the treated mice had many more dormant stem cells than the untreated mice.

Traditionally GABA tells neurons to shut down and not continue to propagate a message to other neurons, says Song. In this case the neurotransmitter also shuts off the stem cells and keeps them dormant.

The brain stem cell population in mice (and other mammals, including humans) is surrounded by as many as 10 different kinds of intermingled neurons, says Song, and any number of these may be keeping stem cells dormant. To find out which neurons control the stem cells, the researchers inserted special light-activating proteins into the neurons that trigger the cells to send an electrical pulse, as well as to release neurotransmitter, when light shines on them. By shining light to activate a specific type of neuron and monitoring the stem cells with an electrode, Songs team showed that one of the three types of neurons tested transmitted a signal to the stem cells causing a change in electrical charge in the stem cells. The neurons messaging the stem cells are parvalbumin-expressing interneurons.

Read more here:
Brain's Stem Cells "Eavesdrop" to Find Out When to Act

Emma, a snow-white German shepherd, has been plagued with arthritis for two years, limping and sometimes crying out in pain. But an innovative new procedure using her own stem cells has helped, her veterinarian and owner say.

"Her joint mobility has improved. I can move her elbows into a flexed position now," said Kristina Hansson, a veterinarian with San Rafael's Northbay Animal Hospital. Hansson injected Emma's own stem cells into 10 of her joints three months ago in a yet-unproven procedure that cost about $2,000, promoted by MediVet America, a Kentucky company.

"We're very pleased," said Arthur Latno of San Rafael, owner of the 9-year-old, 80-pound dog. "She doesn't limp any more and she doesn't cry."

Latno

He is apparently one of the first Marin pet owners to do so. Though there are some practitioners in Marin who use stem cell therapy, it is not yet widespread, according to Andrew Lie, a veterinarian at the East San Rafael Veterinary Clinic and president of the Marin County Veterinary Medical Association.

Lie himself doesn't use the therapy. "Personally, I think I would wait to see more research and studies come out. I think it's a little early

"This (the stem cell procedure) is incredibly promising, but on the other hand there is a lot of homework that needs to be done to determine whether these are valid therapeutic measures," said John Peroni, an associate professor at the University of Georgia College of Veterinary Medicine.

Peroni also chairs the North American Veterinary Regenerative Medicine Association. Peroni himself, along with colleagues at other universities including the University of California at Davis, is engaged in controlled clinical trials involving stem cells and animals. When such trials, peer-reviewed work and long-term studies are published, the effectiveness of the procedures will be easier to determine.

Dogs aren't the only mammals getting stem cell therapy for arthritis. The treatment is being used on humans as well. One example is the Centeno-Schultz Clinic in Broomfield, Colo, which offers a treatment called Regenexx that has received a good deal of media coverage. As with the animal procedure, it involves using a patient's own stem cells.

When the term "stem cells" is used, it brings to mind controversial procedures involving human embryos. In the MediVet procedure, however, the stem cells come from the animal's own body.

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San Rafael dog gets arthritis relief from stem cell treatment

ANN ARBOR In the first human study of its kind, researchers found that using stem cells to re-grow craniofacial tissues mainly bone proved quicker, more effective and less invasive than traditional bone regeneration treatments.

Researchers from the University of Michigan School of Dentistry and the Michigan Center for Oral Health Research partnered with Ann Arbor-based Aastrom Biosciences Inc. in the clinical trial, which involved 24 patients who required jawbone reconstruction after tooth removal.

Patients either received experimental tissue repair cells or traditional guided bone regeneration therapy. The tissue repair cells, called ixmyelocel-T, are under development at Aastrom, which is a UM spinout company.

For a video of the procedure, see: http://youtu.be/lWu_DEJfZVk

In patients with jawbone deficiencies who also have missing teeth, it is very difficult to replace the missing teeth so that they look and function naturally, said Darnell Kaigler, principal investigator and assistant professor at the UM School of Dentistry. This technology and approach could potentially be used to restore areas of bone loss so that missing teeth can be replaced with dental implants.

William Giannobile, director of the Michigan Center for Oral Health Research and chair of the UM Department of Periodontics and Oral Medicine, is co-principal investigator on the project.

The treatment is best suited for large defects such as those resulting from trauma, diseases or birth defects, Kaigler said. These defects are very complex because they involve several different tissue types bone, skin, gum tissue and are very challenging to treat.

The main advantage to the stem cell therapy is that it uses the patients own cells to regenerate tissues, rather than introducing man-made, foreign materials, Kaigler said.

The results were promising. At six and 12 weeks following the experimental cell therapy treatment, patients in the study received dental implants. Patients who received tissue repair cells had greater bone density and quicker bone repair than those who received traditional guided bone regeneration therapy.

In addition, the experimental group needed less secondary bone grafting when getting their implants.

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Stem Cell Therapy Could Offer New Hope For Head, Mouth Injuries, Defects

When transplanted into guinea pig hearts, human heart muscle cells (pictured) can beat in time with resident cells.

MEDIMAGE / SPL

Damaged skin and liver can often repair themselves, but the heart rarely heals well and heart disease is the world's leading cause of death. Research published today raises hopes for cell therapies, showing that heart muscle cells differentiated from human embryonic stem cells can integrate into existing heart muscle[1].

What we have done is prove that these cells do what working heart muscles do, which is beat in sync with the rest of the heart, says Chuck Murry, a cardiovascular biologist at the University of Washington in Seattle, who co-led the research.

It has been difficult to assess cell therapies in animal models because human cells cannot keep up with the heart rates of some small rodents. Cardiomyocytes derived from human embryonic stem (ES) cells typically beat fewer than 150 times a minute. External electrical stimulation can increase that rate, but only up to about 240 beats per minute, says Michael LaFlamme, a cardiovascular biologist at the University of Washington and the other co-leader on the project. Rats and mice have heart rates of around 400 and 600 beats per minute, respectively.

However, guinea pigs have a heart rate of 200250 beats per minute, near the limit for human cardiomyocytes. After working out ways to suppress guinea pigs immune systems so that they would accept human cells, Murry, LaFlamme and their co-workers began transplantation experiments. They also devised a way to make assessing electrical activity straightforward: using recent genetic-engineering technology, they inserted a sensor gene into the human ES cells so that cardiomyocytes derived from them would fluoresce when they contracted.

From the first experiment with the sensor in guinea pigs, it was obvious that the transplanted cells were beating in time with the rest of the heart, says LaFlamme. When he looked into the chest cavity, the heart was flashing back at us, he says.

The human cells seemed to aid healing: four weeks after the researchers killed regions of the guinea pigs hearts to simulate a heart attack, the hearts of animals that received cardiomyocytes exhibited stronger contractions than those that received other cell types. And cardiomyocyte transplants did not seem to cause irregular heartbeats, a common concern for cell-replacement therapy in the heart. In fact, the transplants seemed to suppress arrhythmias.

But it will be a long road from demonstrating this sort of integration to demonstrating possible therapeutic benefits, says Glenn Fishman, a cardiologist at New York University Langone School of Medicine, who was not involved in the work. The conclusion that the human cells can connect with the guinea pig tissue is true, he says, but the clinical implications are a bit of a stretch.

Cardiomyocytes engrafted in only a tiny percentage of scar tissue, Fishman explains, and the area seems too small to produce much additional pumping force. He suspects that the benefits seen stem from the 'paracrine effect', in which transplanted cells secrete factors that rejuvenate damaged host tissue. In fact, many researchers are exploring such strategies to prompt damaged heart tissue to restore itself, he says.

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Guinea pig hearts beat with human cells

AP

Raiders linebacker Aaron Curry isnt sure when hell be able to get back on the field, but hes pretty sure that stem cell therapy will be the thing that winds up getting him back there.

Paul Gutierrez of CSNBayArea.com reports that Curry has received the therapy on both of his knees. Bone marrow from his hips was used in the treatment and Curry told Gutierrez that it is the only thing hes tried that has helped him feel better. Curry is still working out on the side during Raiders practices and said hell only return to practice when hes fully able to help the Raiders.

My goal is to get healthy and just go out there and be violent, be fast, be a pain in the offenses butt and whatever I have to do on the defense, do it, Curry said. And do it full speed. I cant do that until my body says its ready.

The treatment has been popular with Oakland athletes. Linebacker Rolando McClain said that the treatment helped his legs feel better earlier this offseason and As pitcher Bartolo Colon has credited stem cell treatment on his shoulder with saving his baseball career.

With McClain facing a possible suspension under the Personal Conduct Policy and Oakland short on linebacking depth, the Raiders need Curry to be healthy for the start of the season.

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Aaron Curry using stem cell therapy to help knees

Take a close look at the athletes competing in this year's Summer Olympic Games in London --their musculature will tell you a lot about how they achieved their elite status. Endless hours of training and commitment to their sport played a big role in building the bodies that got them to the world's premier athletic competition. Take an even closer look--this one requires microscopy--and you'll see something else, something embedded in the genetic blueprints of these young men and women that's just as important to their success. [More]

Source:
http://rss.sciam.com/sciam/topic/gene-therapy

From Nature magazine

[More]

Source:
http://rss.sciam.com/sciam/topic/gene-therapy

One day in early 1995 a man named bob massie walked into my office at the outpatient clinic of Massachusetts General Hospital in Boston. Massie told me he had been infected with HIV--the virus that causes AIDS--for 16 years and yet had never shown any symptoms. My physical examination confirmed he was healthy, in stark contrast to all other patients I saw that day. At that time, a new combination of drugs was being tested that would eventually slow the progressive decline in immune function that HIV caused. In 1995, however, most people who had been infected with HIV for a decade or more had already progressed to AIDS--the stage marked by the inability to fight off other pathogens. The young man standing before me had never taken anti-HIV medication and strongly believed that if I learned the secret to his good fortune, the information could help others to survive what was then generally thought to be a uniformly fatal disease.

[More]

Source:
http://rss.sciam.com/sciam/topic/gene-therapy

Tears and a runny nose can be unpleasant on a windy day, but these mucosal secretions play a vital role in protecting the body from viruses and other malicious microbes. Unfortunately, mucus is also adept at washing away medication designed to treat infections and inflammation that occur when an infectious agent is successful in penetrating the body's defenses [More]

Source:
http://rss.sciam.com/sciam/topic/gene-therapy

Proposition 71 last week once again
stood in the way of action by the $3 billion California stem cell
agency.

Source:
http://californiastemcellreport.blogspot.com/feeds/posts/default?alt=rss

A bit of irony popped up this
week in the wake of approval of $151 million in awards by the
California stem cell agency.

"We will take CIRM money last. We
don't want to be in a position where, years from now, we are actually
forced to sell [our products] in California at a loss."

“We are extremely grateful to CIRM
for its support.”

Source:
http://californiastemcellreport.blogspot.com/feeds/posts/default?alt=rss

Take a close look at the athletes competing in this year's Summer Olympic Games in London --their musculature will tell you a lot about how they achieved their elite status. Endless hours of training and commitment to their sport played a big role in building the bodies that got them to the world's premier athletic competition. Take an even closer look--this one requires microscopy--and you'll see something else, something embedded in the genetic blueprints of these young men and women that's just as important to their success. [More]

Source:
http://rss.sciam.com/sciam/topic/gene-therapy

From Nature magazine

[More]

Source:
http://rss.sciam.com/sciam/topic/gene-therapy

One day in early 1995 a man named bob massie walked into my office at the outpatient clinic of Massachusetts General Hospital in Boston. Massie told me he had been infected with HIV--the virus that causes AIDS--for 16 years and yet had never shown any symptoms. My physical examination confirmed he was healthy, in stark contrast to all other patients I saw that day. At that time, a new combination of drugs was being tested that would eventually slow the progressive decline in immune function that HIV caused. In 1995, however, most people who had been infected with HIV for a decade or more had already progressed to AIDS--the stage marked by the inability to fight off other pathogens. The young man standing before me had never taken anti-HIV medication and strongly believed that if I learned the secret to his good fortune, the information could help others to survive what was then generally thought to be a uniformly fatal disease.

[More]

Source:
http://rss.sciam.com/sciam/topic/gene-therapy

Tears and a runny nose can be unpleasant on a windy day, but these mucosal secretions play a vital role in protecting the body from viruses and other malicious microbes. Unfortunately, mucus is also adept at washing away medication designed to treat infections and inflammation that occur when an infectious agent is successful in penetrating the body's defenses [More]

Source:
http://rss.sciam.com/sciam/topic/gene-therapy

Proposition 71 last week once again
stood in the way of action by the $3 billion California stem cell
agency.

Source:
http://californiastemcellreport.blogspot.com/feeds/posts/default?alt=rss

A bit of irony popped up this
week in the wake of approval of $151 million in awards by the
California stem cell agency.

"We will take CIRM money last. We
don't want to be in a position where, years from now, we are actually
forced to sell [our products] in California at a loss."

“We are extremely grateful to CIRM
for its support.”

Source:
http://californiastemcellreport.blogspot.com/feeds/posts/default?alt=rss

By Lisa Esposito HealthDay Reporter

WEDNESDAY, Aug. 1 (HealthDay News) -- While scientists hotly debate the existence of cancer stem cells, three related new studies, all conducted on mice, provide some supporting evidence.

Stem cells are the foundation for healthy cell growth in the body. Some researchers believe that malignant stem cells also exist -- so-called cancer stem cells that generate tumors and resist treatment by simply re-growing afterward.

"Cancer stem cells are still controversial, but with progress in studies like these, it's less about whether they exist and more about 'what does this mean?'" said Dr. Max Wicha, director of the University of Michigan Comprehensive Cancer Center, who is familiar with the new findings.

Appearing online Aug. 1 in the journal Nature, one study involved mice with glioblastoma, the most common malignant brain tumor in adults and a particularly lethal cancer.

Researchers led by Luis Parada, a professor and chairman of developmental biology at University of Texas Southwestern Medical Center in Dallas, genetically engineered mice so they would develop glioblastoma.

Then they developed a "transgene" designed only to be active in stem cells in healthy adult brains. They marked this transgene with a green fluorescent protein so the researchers would see it wherever it appeared.

To this transgene they added a virus gene that would self-destruct if treated with the drug acyclovir.

Next, they put the transgene into the mice, which developed tumors. In every mouse, a subset of cells in the malignant brain tumor cells was green.

"The next obvious question was: Since the 'transgene' was designed to be active in stem cells, might these be stem cells?" Parada said.

Link:
Evidence Grows That Cancer Has Its Own Stem Cells

Not one, not two, but three brand new studies point to growing evidence that the reason cancer is so stubbornly resistant to treatment is that it has its very own stem cells. These cells may allow the cancer to start growing again. Speaking to a HealthDay reporter, Dr. Max Wicha, director of the University of Michigan Comprehensive Cancer Center, commented on one of the studies, which was published online in the journal Nature."Cancer stem cells are still controversial, but with progress in studies like these, it's less about whether they exist and more about 'what does this mean?'" he said.

One study involved mice with a common and particularly lethal form of brain cancer. Lead researcher Luis Prada of the University of Texas Southwestern Medical Center in Dallas and colleagues genetically engineered mice so they would develop the cancer. After that they created a "transgene" that would only to become active in stem cells in healthy adult brains and they gave the transgene a green fluorescent marker. Finally, they added a virus gene that would self-destruct if treated with a drug called acyclovir. When they put the transgene into the mice with tumors, cells in the tumors were green.

HealthDay quotedPrada as saying, "The next obvious question was: Since the 'transgene' was designed to be active in stem cells, might these be stem cells?" To answer their question, the research team gave acyclovir to the mice. "And when we did that, the tumors stopped growing," Prada said.

"It's interesting that all the studies came to the same conclusion with different types of cancer," Wicha told HealthDay. He added that early clinical studies are already in the works using drugs to target the cancer stem cells.

Follow this link:
Cancer May Have Its Own Stem Cells