StemCell Therapy

1:00 AM A limited study finds the cells don't need to come from patients to work, a key advance in treatment.

By Marilynn Marchione, The Associated Press

LOS ANGELES - Researchers are reporting a key advance in using stem cells to repair hearts damaged by heart attacks. In a study, stem cells donated by strangers proved as safe and effective as patients' own cells for helping restore heart tissue.

click image to enlarge

Dr. Joshua M. Hare, who led the stem cell study, performs a heart biopsy in October.

The Associated Press/University of Miami

The work involved just 30 patients in Miami and Baltimore, but it proves the concept that anyone's cells can be used to treat such cases. Doctors are excited because this suggests that stem cells could be banked for off-the-shelf use after heart attacks, just as blood is kept on hand now.

Results were discussed Monday at an American Heart Association conference in California and published in the Journal of the American Medical Association.

The study used a specific type of stem cells from bone marrow that researchers believed would not be rejected by recipients. Unlike other cells, these lack a key feature on their surface that makes the immune system see them as foreign tissue and attack them, explained the study's leader, Dr. Joshua Hare of the University of Miami.

The patients in the study had suffered heart attacks years earlier, some as long as 30 years ago. All had developed heart failure because the scar tissue from the heart attack had weakened their hearts so much that the hearts grew large and flabby, unable to pump blood effectively.

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Strangers' stem cells used to fix hearts

Study Highlights:

LOS ANGELES, Nov. 5, 2012 (GLOBE NEWSWIRE) -- Stem cells taken from patients or donors can treat people with enlarged hearts safely and with similar effectiveness, according to late-breaking clinical trial results presented at the American Heart Association's Scientific Sessions 2012.

The Comparison of Allogeneic vs. Autologous Bone Marrow Derived Mesenchymal Stem Cells Delivered by Transendocardial Injection in Patients with Ischemic Cardiomyopathy trial (POISEIDON) is also published in the Journal of the American Medical Association.

"This cell therapy clearly had some clinical benefits and the mesenchymal stem cells from donors were just as safe as those from the recipient," said Joshua Hare, M.D., the lead study author. "Even in patients who had heart attacks several decades before treatment, both donor and recipient stem cells reduced the amount of scarring substantially, by one-third."

The mesenchymal stem cells (MSCs) -- unique because the body's protective antibodies don't attack them -- are found in adults' bone marrow.

Previous studies indicated that MSCs might improve heart muscle function in patients with heart scarring from a prior heart attack. Heart muscle weakening from such scars (ischemic cardiomyopathy) is the most common cause of debilitating and deadly congestive heart failure.

The 13-month trial is the first to compare the safety and efficacy of MSCs taken from the patients themselves against MSCs provided by donors. Thirty patients with chronic ischemic cardiomyopathy received various doses of MSCs. Half received their own cells, while the other half received donor cells. Heart failure class improved in 28 percent of those receiving donor cells, and in 50 percent of those receiving their own cells.

Regenerating new heart muscle with MSCs requires growing large amounts of the stem cells, which takes six to eight weeks. Using already-prepared donor cells might avoid this delay to treatment.

"Because antibodies don't attack MSCs, donor cells can be prepared in advance and stored until needed," said Hare, a professor of medicine and director of the Interdisciplinary Stem Cell Institute at the University of Miami Miller School of Medicine in Florida. "Perhaps using donor cells is the more feasible approach."

The stem cells were delivered directly into the damaged area of patients' heart muscle using a catheter with a needle tip. "An additional important finding was the safety of this new cardiac catheterization technique," said study co-author Alan Heldman, M.D., a cardiologist and Professor of Medicine in the University of Miami Health System, who performed the minimally-invasive procedures.

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Stem Cells From Patients or Donors May Help Treat Diseased Hearts

454: A Documentary About Stem Cell Research
In 2004 Alex Goldberg, then a 20 year old local filmmaker began a documentary on stem cell research at the University of Washington. On June 16 2011, he died before the film was finished. This film highlights the need for this research to continue in order to save thousands of lives. In this unsettling political climate, the film resonates. It was made during the Bush era when stem cell lines were limited, thus stunting the research and in turn a cure for so many diseases. Many thanks to Dr Charles Murry and his staff for their tireless efforts to create therapies in regenerative medicine. Dr Murry may be reached through the University of Washington research labs. If you would like to make donations to help fund this research and the researchers who work without appropriate compensation please click the following link: depts.washington.eduFrom:Leta GoldbergViews:67 2ratingsTime:15:03More inEducation

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454: A Documentary About Stem Cell Research - Video

umbilical cord stem cells | Cord Blood Storage and Why
http://www.cordbloodrecommendation.com By preserving this cord blood through cord blood banking, your baby will be ensured a perfect source of cells in the event of some unfortunate accident, disease or other life threatening illness. Safety is a concern in the public banks because of the high cost of maintaining the storage unit. Besides this, children without siblings and people belonging to certain races or ethnicities, who don #39;t have access to other people of their race in their area, also face problems. Sources of stem cells, such as blood, fats, bone, or umbilical cords were simply named as sources, not as natural resources. By preserving your baby #39;s cord blood, you are actually saving your child from the dangers of waiting for matching donors during emergencies. ""Regenerative medicine is the next evolution of medical treatments. Stromal cells are a kind of cells that form bone, cartilage, fat, and fibrous connective tissue. There are people who are against this practice as well and there are many opinions supporting it too therefore it is best to consult your doctor regarding this issue and get the right advice. For this, the patient needs a donor whose tissues and cells match his own. In case the cord blood is collected before the removal of placenta, the umbilical cord is clamped and detached as usual. - Stem groups can be certainly obtained from cord blood- flex blood stem groups are a 100% reach for the patron, 50% reach for biological parents and 25% reach for blood ...From:Alexander santafeViews:0 0ratingsTime:01:13More inScience Technology

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umbilical cord stem cells | Cord Blood Storage and Why - Video

Gov. Rick Perry today highlighted Texas leading role in the advancement of regenerative medicine to produce safe, effective and ethical adult stem cell therapies. The governor spoke at the inaugural Houston Stem Cell Summit, which focuses on adult stem cell research and its potential to tackle life-threatening diseases.

Im proud Texas is playing a key role in the advancement of adult stem cell research and therapies, both of which are promising for patients and our economy, Gov. Perry said. This conference represents another step in the growth of this industry that I hope and expect will be centered right here in the Lone Star State.

Texas has taken clear steps to advance research in ethical regenerative medicine as quickly and safely as possible, while protecting patients receiving these treatments in the state. Earlier this year, the Texas Legislature, Texas Medical Board and Texas Department of Health and Human Services set up a regulatory framework to guide companies, institutions and physicians collaborating to produce effective stem cell research.

Additionally, Texas continues to attract top researchers in biotechnology and regenerative medicine thanks to our commitment to investing in the technologies of the future through the Cancer Prevention Research Institute of Texas (CPRIT) and Texas Emerging Technology Fund (TETF). CPRIT has funded 427 awards totaling more than $756 million for cancer research, commercialization and prevention in academic institutions, non-profit organizations and private companies. The TETF has invested more than $180 million in grant-matching and research superiority funds in Texas universities, and more than $194 million in 137 early-stage companies, with more than $103 million of that going directly to biotechnology and life science companies.

Texas researchers have also received more than $52 million in National Institute of Health (NIH) funding in 2009 for adult stem cell studies. These grants have resulted in the Austin Heart Hospital successfully treating heart attack patients with adult stem cells, and success in treating spinal cord injuries and a variety of heart conditions.

The Houston Stem Cell Summit highlights the latest research and breakthroughs regarding the use of adult stem and progenitor cell therapies. The summit covers all aspects of emerging stem cell therapies including the latest in peer reviewed academic stem cell research, breakthroughs in adult stem cell therapies, patient experiences, the business of stem cell therapies and the evolving regulatory environment for stem cell therapies. For more information, please visit http://www.stemcellsummit.com/houston/. To view the governors full remarks, please visit http://governor.state.tx.us/news/speech/17803/

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Texas Can Become Center for Regenerative Medicine

Public release date: 5-Nov-2012 [ | E-mail | Share ]

Contact: Katie Pence katie.pence@uc.edu 513-558-4561 University of Cincinnati Academic Health Center

CINCINNATIHoxworth Blood Center, the University of Cincinnati (UC) and Cincinnati Children's Hospital Medical Center will host the Midwest Symposium on New Concepts For Tissue-Specific Regenerative Medicine, Nov 17-18, 2012, in Rieveschl Auditorium of the Vontz Center for Molecular Studies.

The symposium, also being co-sponsored and co-funded by UC's Center for Clinical and Translational Science and Training (CCTST), will focus on research and collaboration regarding regenerative medicinethe process of regenerating human cells, tissues or organs to restore or establish normal function.

The field holds the promise of repairing damaged tissues and organs in the body by stimulating the body's own repair mechanisms or by growing replacement tissues in labs.

Jose Cancelas, MD, PhD, professor of pediatrics at the UC College of Medicine and director of the research division at Hoxworth Blood Center, is a co-organizer of the symposium and says regenerative medicine expertise is very strong in the region.

"The purpose of the symposium will be to create a forum where investigators and their groups can meet and share ideas and data," he says. "In addition, it will serve as an excellent platform for regional scientific interactions for investigators, postdocs and students that have interest in regenerative medicine and stem cell biology. Hopefully, this meeting will spark collaborations locally and regionally."

Specifically, the meeting will focus on research using stem cells in the body, or those manipulated in a petri dish, to study disease, generate therapeutic tissues and create genetic therapies.

Keynote speakers will deliver addresses followed by short oral presentations with extended discussions to allow interaction among attendees.

"Research presentations will span from how scientists are looking at the use of stem cells to assist with gastrointestinal, pancreas, lung, corneal, skeletal muscle, vascular and cardiac regeneration to genetic therapies and how this research could and is translating to treatment," Cancelas says. "There's a wealth of scientific and clinical stem cell work being done right here in Cincinnati.

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Midwest regenerative medicine symposium to be held in Cincinnati

The world's first mass-market gene therapy has been legalized in Europe. Glybera, which treats a painful disorder that leads to pancreatitis, will be available in hospitals beginning next year.

Chances are you haven't heard much about lipoprotein lipase deficiency (LPLD), a disease that leads to pancreatitis. This rare disease, however, is at the center of world-changing medical advances.

Last week the European Union approved a gene therapy treatment for LPLD--and this marks the first time any medical treatment that rewrites a patients' DNA has been approved for commercial use.

The treatment, called Glybera, will be released by Dutch firm uniQure in the second half of 2013. Glybera will be administered to patients by specially trained doctors at a limited number of European hospitals. Patients receiving treatment have their DNA altered by a series of injections into their leg muscles, which helps normalize the metabolism of fat particles carried in the blood. LPLD prevents sufferers from properly metabolizing these particles, leading to a host of side effects including pancreatitis.

Gene therapy is an emerging form of medicine, focusing on the use of DNA to rewrite or supplement existing genes. This experimental practice is expected to lead to a series of breakthroughs over the next 50 or so years for various types of cancers, Parkinson's disease, sickle cell anemia, and a host of inherited conditions. Studies involving different forms of gene therapy are currently under way in Europe and the United States--one famous case in 2007 involved a man who was cured of HIV through stem cell transplantation. Stem cell transplants are one type of gene therapy used to give patients therapeutic DNA; other methods use different sources.

LPLD affects approximately one in 1,000,000 people worldwide. Apart from (frequently fatal) acute pancreatitis, patients regularly suffer from yellow spots on their skin, swollen abdomens, enlarged livers, severe abdominal pain, and diarrhea. The condition is currently treated through diet--patients are encouraged to go on a strict low-fat, alcohol-and-red-meat-free diet to mitigate symptoms.

By helping to normalize the metabolism of fat, Glybera prevents inflammation of the pancreas thereby averting the associated pain and suffering and, if administered early enough, the associated co-morbidities, said Professor John Kastelein of the University of Amsterdam in a statement.

Gene therapy treatments in the United States are primarily focused on cancer, including leukemia. No other gene therapy products are expected to be approved by major medical regulator agencies in 2012. The European Commission, which handles medical approvals for Europe, is widely considered to have a bureaucratic pipeline that is far more open to gene therapy than the United States.

[Image: DNA damage via Tom Ellenberger/Washington University School of Medicine]

For more stories like this, follow @fastcompany on Twitter. Find Neal Ungerleider, the author of this article, on Twitter.

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DNA Hacking Is Now Street Legal

JUPITER, Fla., Nov. 5,2012 /PRNewswire/ --BioRestorative Therapies, Inc. ("BRT" or the "Company") (OTCBB: BRTX),a life sciences company focused on stem cell based cellular therapies for various personal medical applications, announced todaythat its common stock hasbegun trading on theOTC Bulletin Board.

Mark Weinreb, Chief Executive Officer of BRT, commented on the uplisting, "We went through a very thorough and diligent review process by FINRA to attain the Bulletin Board listing. The Bulletin Board trading platform allows for more potential investors interested in purchasing our stock.We are extremely pleased to provide investors increased visibility and transparency that this regulated quotation service provides so the Company can continue the pursuitof itsgoal of becoming a leader in developing ground-breaking medical procedures."

About BioRestorative Therapies, Inc.

BioRestorative Therapies, Inc.("BRT") developsmedical procedures using cell and tissue protocols, primarily involving adult stem cells (non-embryonic), and allowing patients to undergo minimally invasive cellular-based treatments.BRT is developing the following scientific initiatives:OurbrtxDISCProgram (DiscImplanted StemCells)offers a non-surgical treatment for bulging and herniated discs andaddresses the gap between non-invasive and invasive back procedures.

OurThermoStemProgramfocuses on treatments for metabolic disorders (diabetes, heart disease, etc.) and obesity anduses brown fat stem cells. Initial research indicates that increased amounts of brown fat in the body may be responsible for additional caloric burning as well as reduced glucose and lipid levels in the body. The Company also offers plant stem cell-based facial creams and products under theStem Pearlsbrand atwww.stempearls.com.

This press release contains "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and such forward-looking statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause future circumstances, events or results to differ materially from those projected in the forward-looking statements as a result of various factors and other risks, including those set forth in the Company's Form 10-K filed with the Securities and Exchange Commission. You should consider these factors in evaluating the forward-looking statements included herein, and not place undue reliance on such statements. The forward-looking statements in this release are made as of the date hereof and the Company undertakes no obligation to update such statements.

Investor Contacts: KCSA Strategic Communications Philip Carlson / Josh Dver +1 212.896.1233/+1 212.896.1239 pcarlson@kcsa.com / jdver@kcsa.com

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BioRestorative Therapies Announces Stock Trading On OTC Bulletin Board

25. Medical Biotechnology: Part Ib. Stem Cells-Therapy and Medical Research NQ
Stem cell research has created national, if not global controversy. Why? What divides our thinking about stem cell research? This section provides the basics on stem cell research including: embryonic stem cells; adult stem cells; and, induced pluri-potent stem cells. Also discussed are their potential therapeutic application for degenerative diseases.From:Albert KauschViews:1 0ratingsTime:36:03More inScience Technology

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25. Medical Biotechnology: Part Ib. Stem Cells-Therapy and Medical Research NQ - Video

cord blood center | Cord Blood Transplantation - A Life Savior Technique
http://www.cordbloodrecommendation.com Storing your babies blood is painless, and causes no harm or pain to the child or mother. Anything that can help cure illnesses and several genetic diseases is worth at least researching and contemplating because you really do never know when you may need it. This type of stem cells is found in baby cord blood and adult bone marrow. Umbilical blood banking provides the ideal stem cell match should a patient require stem cell therapy in their lifetime. Hence opt for cord blood storage banks that can show proof of successful transplants from the cord blood units they have stored in order to avoid rude shocks. If you are an expecting mother, you can look for a bank or designated donation hospital in your community. In cases of leukemia, stem cells can be used to generate healthy blood and fight off the cancer cells in the body. Furthermore, collecting umbilical cord blood has no controversy since the process does not cause the destruction on the embryos and fetus. ""Leukemia is a type of cancer that begins from those tissues in the body that form blood. Ultra-modern cord blood banking technologies induce multiplication of cord blood stem cells by ex vivo expansion. Last but not the least, if you do not want to store the blood for your personal usage in any of these banks you can also donate it to the Medical Institutes for research purposes. Stem cells, researchers discovered, could cure many diseases such as leukemia and help others such as ...From:Implantes DentalesViews:1 0ratingsTime:01:31More inTravel Events

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cord blood center | Cord Blood Transplantation - A Life Savior Technique - Video

FAQ-11 of 19: For Stem Cell Therapy, Why Thailand #39;s Licensed Stem Cell Treatments?
youtu.be You may wonder why coming to Thailand is a better investment of time, energy and resources, so here are some answers. For more personalized information as to how your condition might respond to stem cell therapy, go to the Apply Now page and send in copies of your medical records with an Application for Consideration. StemCell-Asia.infoFrom:Karridine1Views:1 0ratingsTime:01:16More inPeople Blogs

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FAQ-11 of 19: For Stem Cell Therapy, Why Thailand's Licensed Stem Cell Treatments? - Video

Arthritis
Call: 305-695-7777 For More Information Arthritis has been something historically very hard to cure, but we maybe one step closer to a cure by using stem cell therapies instead of steroids and other types of medications. At Miami Beach Foot and Ankle Surgery we have been utilizing PRP (platelet rich plasma) therapy as well as amniotic stem cell therapy, which is important in the world of arthritis.From:MiamiFootSurgeryViews:11 0ratingsTime:01:12More inHowto Style

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Arthritis - Video

Muscular Dystrophy Before and After Stem Cell Therapy
He took stem cell therapy at NeuroGen. Previously when he was climbing stairs, he was widening steps and climbing stairs. And he was taking more time, now he is taking less time. Climb stairs straight. Previously during sit to stand, he was taking support of hands and was coming up, but now he is not taking support. Previously when he was sitting on floor, he was facing in coming up and facing problem in walking few steps. But after stem cell therapy he can walk normally now. Now changes are seen. Stem Cell Treatment done at Neurogen ,Brain Spine Institute, Surana Sethia Hospital and Research Centre, Suman Nagar, Sion-Trombay Road, Chembur,Mumbai-71. Website -- http://www.neurogen.in http://www.stemcellsmumbai.com Tel: - +91 9920 200400, 022-25283706From:neurogenbsiViews:0 0ratingsTime:00:37More inScience Technology

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Muscular Dystrophy Before and After Stem Cell Therapy - Video

Lysosomal Storage Disorders
ll4.me Lysosomal Storage Disorders From Lysosomes to Storage Diseases and Back: A Personal Reminiscence.- Lysosomal Biogenesis and Disease.- The Concept of Treatment in Lysosomal Storage Diseases.- Complex Lipid Catabolism.- Retroviral Vectors for Gene Therapy.- Adenovirus in Gene Therapy.- Setting Back the Clock: Adenoviral-Mediated Gene Therapy for Lysosomal Storage Disorders.- Adeno-Associated Viral-Mediated Gene Therapy of Lysosomal Storage Disorders.- Herpes Simplex Virus Vectors for Gene Therapy of Lysomal Storage Disorders.- Gene Therapy of Lysosomal Storage Disorders by Lentiviral Vectors.- Substrate Reduction Therapy.- Newborn Screening for Lysosomal Storage Disorders.- Genetic Counseling for Lysosomal Storage Diseases.- Neural Stem Cell Therapy in Lysosomal Storage Disorders.- The GM1 Gangliosidoses.- The GM2 Gangliosidoses.- Acid Sphingomyelinase-Deficient Niemann-Pick Disease.- Krabbe Disease (Globoid Cell Leukodystrophy).- Metachromatic Leukodystrophy.- Fabry Disease.- Gaucher Disease: Review and Perspectives on Treatment.- Therapeutic Goals in the Treatment of Gaucher Disease.- The Neuronal Ceroid Lipofuscinoses: Clinical Features and Molecular Basis of Disease.- Mucopolysaccharidosis I.- Mucopolysaccharidosis II.- Sanfilippo Syndrome: Clinical Genetic Diagnosis and Therapies.- Mucopolysaccharidosis IV (Morquio Syndrome; MPS IV).- Mucopolysaccharidosis Type VI (MPS VI, Maroteaux-Lamy Syndrome).- Mucopolysaccharidosis Type VII (Sly Disease): Clinical, Genetic ...From:davidbrown9865Views:0 0ratingsTime:00:13More inPeople Blogs

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Lysosomal Storage Disorders - Video

The Patients of Angeles Health International
What our patients have to say about their experiences at Angeles Health International. All patients were treated for different conditions, in separate departments throughout our facilities. Angeles Health International offer cutting edge care, procedures and treatment in the following areas: Weight Loss Surgery - http://www.weightlossmex.com Stem Cell Therapy - http://www.stemcellmx.com Multiple Sclerosis Treatment - http://www.ccsvi.mx Effective Chemotherapy-free Cancer Treatment - http://www.cancertreatmentmx.com Visit the Angeles Health International website here: http://www.angeleshealth.com There are a team of healthcare professionals waiting to hear from you. Contact Angeles Health International toll free on: 1.866.668.9263From:AngelesHealthViews:0 0ratingsTime:03:06More inScience Technology

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The Patients of Angeles Health International - Video

Stem Cell Malaysia | Stem Cell Therapy
stemcellmalaysia.com Stem Cell Malaysia shares with you actual user experience on stem cell therapy. Stem Cell Malaysia also provides useful information on stem cells, stem cell therapy, stem cell research and stem cell newsFrom:stemcells2012Views:102 4ratingsTime:03:17More inHowto Style

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Stem Cell Malaysia | Stem Cell Therapy - Video

Stem Cells Doctor in Mexico Shares his Expertise
http://www.mexicohealth.com The video shows a stem cells doctor in Mexico discussing various procedures he specializes in, which notably are multiple sclerosis, brain degenerative disorders, and eye sight rectification. This stem cell specialist has treated over forty patients using cutting edge stem cell therapies. Despite cynical attitudes from different quarters, this doctor represents the vanguard for stem cell treatments for progressively degenerative conditions. To read the transcript and to get a free quote from stem cells doctor in Mexico. Click the link above. Related Searches: Stem Cell Therapy Doctors Mexico, stem cell treatment glaucoma mexico, stem cell therapy brain disorders mexico, stem cell therapy brain injury mexico, stem cell treatment spinal cord MX,From:mexicohealthViews:3 0ratingsTime:04:05More inPeople Blogs

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Stem Cells Doctor in Mexico Shares his Expertise - Video

Stem Cells Treatment in Mexico - Reports You #39;ll Need
http://www.mexicohealth.com The video shows a top stem cell specialist emphasizing the importance of reports and records in devising a sure shot stem cell treatment. Mexico is going where others have feared to tread by investing heavily in stem cell research and development. Not all conditions are curable using stem cells. Some even require a certain degree of faith in your doctor. This doctor has helped more than 40 patients to get up on their feet. Communication is the key, as this doctor points out. If you #39;re mulling over getting a stem cell treatment in Mexico, for yourself or somebody you know, always remember to carry exhaustive reports. To get a free quote, click the link above. Related Searches: stem cell therapy specialists mexico, Stem Cell Treatment for Multiple Sclerosis Mexico, Stem Cell Therapy in Mexico for Chronic Heart Failure, Adult Stem Cell Treatment in Mexico, Stem Cell Therapy for Diabetes Mexico, stem cell treatment for brain damage Mexico, Stem Cell Treatment for Neurodegenerative Conditions mexico, Stem Cell Treatment for Eye Diseases Mexico, Stem Cell Treatment for Heart Conditions Mexico, Stem Cell Therapy for Brain Injury Mexico,From:mexicohealthViews:3 0ratingsTime:02:08More inPeople Blogs

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Stem Cells Treatment in Mexico - Reports You'll Need - Video

Autologous and Adult Stem Cells Transplant in Mexico
http://www.mexicohealth.com The video shows a top stem cell specialist in Mexico explaining why autologous stem cell treatment is a better choice than adult stem cell transplant. The doctor goes on to caution about risks of reaction in case of adult stem cells transplant. In some cases, the reaction could kill. Autologous, on the other hand, is a safe proposition. The doctor has been in the profession since 1978 and has treated over 40 patients with acute degenerative disorders like, multiple sclerosis. To read the transcript of the video about autologous and adult stem cell transplant in Mexico, click the link above. Related Searches: Autologous stem cell transplant mexico, Hematopoietic stem cell transplantation mexico, Stem Cell Transplantation in Adults mexico, Stem cell treatment ms mexico, stem cell treatment glaucoma mexico, stem cell therapy brain disorders mexico, stem cell therapy brain injury mexico, stem cell treatment spinal cord MX,From:mexicohealthViews:2 0ratingsTime:03:08More inPeople Blogs

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Autologous and Adult Stem Cells Transplant in Mexico - Video

When he was only 43, Peter Harrison had a severe heart attack that left him suffering from the symptoms of a damaged heart: shortness of breath, chest pain and increased risk of another heart attack. An otherwise healthy commercial real estate agent from Key Biscayne, Harrison was in and out of the hospital for 20 years treating his heart condition until last year when doctors at the University of Miami Miller School of Medicine injected his heart with stem cells as part of a study.

Three weeks later, he was hiking the steep hills of the U.S. Virgin Islands, keeping up with his wife.

There was no chest pain and I was not out of breath it was quite a revelation, he said. I was hoping that the damaged part of my heart would come back to life, and the indication is that it has.

The study, which was funded by the National Institutes of Health and published in the Journal of the American Medical Association this week, found that stem cell injections into the heart muscle reduced scar tissue by one third, built up healthy heart tissue and remodeled the spherical shape of the damaged heart to look more like a football-shaped healthy heart.

Dr. Joshua Hare, the director of the UM Interdisciplinary Stem Cell Institute and the lead author of the study, said the stem cells cells that are not fully formed and have the potential to become different kinds of cells internalize information from their milieu to know what to become.

We think the cells respond to environmental cues to determine how they divide and differentiate, he said. The stem cells used in this study were taken from bone marrow and have a limited repertoire of possibility, meaning they are more easily transformed into bone or muscle than blood or brain.

Half of the 30 men enrolled in this small pilot study at UM and Johns Hopkins University received injections of their own stem cells, while the other half got stem cells from a third party donor. Harrison was in the group that got donated stem cells. There are no compatibility requirements for stem cell donors as there is with blood and bone marrow, and one donor can provide enough stem cells for many, many people, Hare said.

This is an elegant treatment in that it doesnt transgress any ethical boundaries, Hare said, alluding to the controversy surrounding the use of stem cells from human embryos. You dont need to create a donor bank, its easy to implement and relatively inexpensive.

Stem cell therapy, a growing area of research, drew attention earlier this year when the Nobel Prize in Medicine went to John B. Gurdon of the University of Cambridge in England and Shinya Yamanaka of Kyoto University in Japan for their work in turning mature cells back into pluripotent stem cells that have the potential to become other types of cells. Hare said the UM study was essentially the opposite rather than reduce mature cells to stem cells, these injections of stem cells differentiated into healthy heart tissue.

Participants were injected with 10 doses of stem cells delivered by a catheter with a cork-screw tip that bored into the heart muscle between damaged and healthy tissue. The randomized trial found best results with the patients who received the smallest dosage 20 million total stem cells compared to other doses of 100 million or 200 million. Further studies are required to determine the ideal dosage for heart patients, and also to explore other applications for this kind of treatment.

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In University of Miami study, stem cell injections repair damaged heart