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Monitoring the Cash and IP at the California Stem Cell Agency

February 24th, 2013 3:02 am

The $3 billion California stem cell
agency appears unlikely to make any changes in who gets the cash from
any commercial products that its research grants help finance despite
recommendations from the Institute of Medicine(IOM).

The subject will come up next Wednesday
during a meeting of the intellectual property subcommittee of the
governing board of the stem cell agency. Intellectual property (IP) simply
determines ownership rights and the share of any revenue from
therapies that result from research.
CIRM staff has prepared a briefing paper with recommendations for next week's meeting, which has
teleconference locations in La Jolla, Los Angeles, two in Irvine
along with the main site in San Francisco.
The document summarized two key IOM
recommendations in this fashion:

“Because CIRM is a new institution
without a track record to reassure stakeholders, and because its
finite funding timeline means as yet unknown agencies will be
enforcing these policies years down the road, CIRM should “propose
regulations that specify who will have the power and authority to
assert and enforce in the future rights retained by the state” in
CIRM IP, specifically referring to march-in rights, access plans and
revenue sharing....

“Second, as other sources of funding
become more prevalent, the agency should “reconsider whether its
goal of developing cures would be better served by harmonizing CIRM’s
IP policies wherever possible with the more familiar policies of the
BayhDole Act.

Here are the CIRM staff
recommendations.

“CIRM staff has engaged in
preliminary discussions several years ago with other agencies
regarding future enforcement of CIRM’s regulations and agreements.
Staff proposes to restart those discussions and return to the
Subcommittee (or the Board) with a formal proposal to address future
enforcement of CIRM’s IP regulations.”

“In light of the IOM’s own
recognition that it may be premature to assess whether CIRM’s
regulations will act as a deterrence to future investment, the fact
that a number of CIRM’s regulations have been codified in statutes
and CIRM’s positive progress in its industry engagement efforts to
date, although quite early, CIRM staff proposes to continue to
monitor this area and not to pursue any changes at this time.”

The director's subcommittee is unlikely
to diverge significantly from the staff proposal, which was dated
Feb. 14 but not posted on the CIRM website until Feb. 20.   

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/xvosTob7Zo0/monitoring-cash-and-ip-at-california.html

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Half-full, Half-empty Editorial on California Stem Cell Agency

February 24th, 2013 3:02 am

The California stem cell agency's
editorial road show paid off a bit again this week with a mildly
approving editorial in the Oakland Tribune.

The Feb.18 piece said that the presence
of Jonathan Thomas, a Los Angeles bond financier, as chairman of the
$3 billion agency has improved things, compared to the reign of Bob
Klein
, who “built a protective shield” around the agency's
governing board and prevented action to deal with obvious
conflict-of-interest problems.
The newspaper also said that “to some
extent” the agency has brought “cutting edge” scientists to the
state and helped boost the stem cell field.
That was the half-full side of the
editorial. The half-empty side included the headline.

“California
must get its stem cell house in order”

The editorial continued:

“...{T)he agency must prove that it
understands how to properly handle the public's money. …. If
the stem cell agency can establish a record as a good steward of
public dollars to finance brilliant science, it can continue to play
a useful role in stimulating and guiding research to bring the
potential cures from stem cell research to fruition.

“If it cannot do that, it will be
just another expensive Tyrannosaurus rex.”

Thomas and company are knocking on
editorial doors around the state in hopes of building support for the
board's modest – some might say inadequate – response to
recommendations for sweeping changes at the agency.  

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/tMt6gs55Yvs/half-full-half-empty-editorial-on.html

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Time For Public Disclosure of Financial Interests of Stem Cell Agency Reviewers

February 24th, 2013 3:02 am

Should the scientists who evaluate
and score the applications for $3 billion in taxpayer funds be
required to publicly disclose their financial interests?

No, says the California stem cell
agency, despite concerns by the state auditor and the state's Fair
Political Practices Commission (FPPC)
that date back at least six
years. The agency says that its governing board makes the decisions
on the applications – not the grant reviewers – and that the
members of the board fully disclose their economic interests.
However, last month the agency produced
a document that sheds new light on the issue. The document confirms
that the board rubber-stamps virtually all the reviewers' decisions,
going along with their actions 98 percent of the time. The board
exercised independent judgment on 28 out of 1,355 applications.
Why is this important? Here is what the state auditor said in 2007,

“(T)he FPPC believes that, under
state regulations, working group members (including grant reviewers)
may act as decision makers if they make substantive recommendations
that are, over an extended period, regularly approved without
significant amendment or modification by the committee. Thus, as
decision makers, working group members would need to be subject to
the conflict-of-interest code. This would mean that working groups
would be subject not only to the (public) financial disclosure requirements of
the Political Reform Act but also to the prohibition against a member
participating in a government decision in which that member has a
disqualifying financial interest and may be subject to the penalties
that may be imposed on individuals who violate that act.”

The auditor recommended that the stem
cell agency seek an attorney general's opinion on the matter, a
recommendation the agency agency summarily dismissed seven months later..
Then interim CIRM
President Richard Murphy, a former member of the agency's board and
former president of the Salk Institute, replied to the auditor:

"We have given careful
consideration to your recommendation and have decided it is not
appropriate to implement at this time. In almost three years of
operation and approval of four rounds of grants, the recommendations
of the CIRM working groups have never been routinely and/or regularly
adopted by the ICOC. Until the time that such a pattern is detected,
the question you suggest we raise with the attorney general is
entirely hypothetical, and is therefore not appropriate for
submission. We will, however, continue to monitor approvals for such
a pattern and will reconsider our decision if one emerges."

In the four rounds mentioned in
Murphy's response, 100 percent of reviewer decisions were
rubber-stamped by the board. In the other two rounds, the percentage
was 95 and 96 percent.
Currently, scientific grant reviewers at the stem cell agency, all of whom are from out-of-state, disclose financial and professional conflicts
of interest in private to selected CIRM officials. (See policy here.)
From time to time, grant reviewers are excused from evaluating
specific applications.
The CIRM governing board has resisted
requiring public disclosure of the interests of reviewers. The subject
has come up several times, but board members have been concerned
about losing reviewers who would not be pleased about disclosing
their financial interests.  Nonetheless, disclosure of interests among researchers is becoming routine in scientific research articles. Many universities, including
Stanford, also require public disclosure of financial interests of
their researchers. Stanford says,

“No matter what the circumstances --
if an independent observer might reasonably question whether the
individual's professional actions or decisions are determined by
considerations of personal financial gain, the relationship should be
disclosed to the public during presentations, in publications,
teaching or other public venues.”

The latest version of CIRM's conflict
of interest rules are under review by the FPPC. They do not include
any changes in public disclosure for grant reviewers. In view of the
new information that confirms that reviewers are making 98 percent of
the decisions on who gets the taxpayers' dollars, it would seem that it is long past due for public disclosure of both financial and professional
interests of reviewers. Indeed, given the nature of scientific
research and the tiny size of the stem cell community, disclosure of
professional interests may be more important than financial
disclosures.
As Francis S. Collins, head of the NIH,
said concerning his organization's own strengthening of disclosure requirements,

"The public trust in what we do is
just essential, and we cannot afford to take any chances with the
integrity of the research process."

Here is the CIRM document concerning
reviewers' decisions and governing board action. The table has not
been posted on the CIRM website, but it was prepared for last month's
meeting dealing with the Institute of Medicine's recommendations for
sweeping changes at the agency, especially related to conflicts of
interest.

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/oma-MLcANoY/time-for-public-disclosure-of-financial.html

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Knee arthritis repair… Is it just injecting stem cells into the knee…No! – Video

February 23rd, 2013 11:44 am


Knee arthritis repair... Is it just injecting stem cells into the knee...No!
http://www.stemcellsarthritistreatment.com Many people are under the illusion that all it takes to treat an osteoarthritic joint is to shoot some stem cells into the joint. Nothing could be further from the truth. Here #39;s why... The success of a stem cell procedure rests on a four-legged stool. The first of course is the stem cell preparation. The second are growth factors that are needed to stimulate stem cell growth and proliferation. The third is a scaffold for the stem cells to adhere to. And the fourth is injury induction in the area that needs to be healed. Without all four critical factors, the procedure is not going to work. http

By: Nathan Wei

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Knee arthritis repair... Is it just injecting stem cells into the knee...No! - Video

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Baylie Faella Pre-Stem Cell Therapy at Abbott Animal Hospital in Rehoboth, MA – Video

February 23rd, 2013 11:44 am


Baylie Faella Pre-Stem Cell Therapy at Abbott Animal Hospital in Rehoboth, MA
Baylie Faella, a 7 year old Lab pre-stem cell therapy who underwent a torn ACL repair. She also suffered from atopy (allergies) and had lesions on her body.

By: Ashraf Gomaa

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Baylie Faella Pre-Stem Cell Therapy at Abbott Animal Hospital in Rehoboth, MA - Video

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Parkinson’s Stem Cell Therapy – Group 28 pm – Video

February 23rd, 2013 11:44 am


Parkinson #39;s Stem Cell Therapy - Group 28 pm
BIOL 1103 Group 28 pm Stem Cell Application Assignment Sources: Euro Stem Cell research: http://www.eurostemcell.org Michael J. Fox Foundation: http://www.michaeljfox.org

By: thehaysdays

Excerpt from:
Parkinson's Stem Cell Therapy - Group 28 pm - Video

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First ever double stem cell therapy procedure to be performed by Branchburg veterinarian

February 23rd, 2013 12:45 am

Now, thanks to participating veterinarians like Dr. Karen Derfuss, DVM, from Branchburg Animal Hospital, who will be conducting a new double stem cell therapy procedure on Tuesday, Feb. 26, and the procedure itself, developed by MediVet America, a new kind of treatment is available for dogs, Auggie and Chloe, and other beloved pets in the Branchburg area.

This new procedure marks a major milestone in regenerative veterinary medicine, said MediVet-America spokesman, Dr. Mike Hutchinson, D.V.M., a leading practitioner in stem cell therapy who has performed more than 400 adipose-derived stem cell treatments on dogs and cats. MediVets superior results made me a believer, and Im excited to share this news with my colleagues.

The procedure uses adult animal stem cell technology and the bodys own regenerative healing power. No embryonic stem cells are used. MediVets kit and equipment enable veterinarians to remove a sample of fat from the pet, separate stem cells from the fat, then activate and inject the cells into the affected area. The entire procedure is all done in-clinic and on the same day.

Within about one month, most animals can be removed from pain and anti-inflammatory drugs. Results show animals that had been unable to climb stairs or jump, now are walking, running and playing.

MediVet is a global leader in veterinary science, with over 1,000 clinics practicing this incredible technology in the US, Mexico, Canada and 28 other countries

About the two dogs:

Auggie is a nine year old loving beagle and a Fathers Day Gift for dad. He is suffering from hip dysplasia, which is an abnormal formation of the hip socket that, in its more severe form, can eventually cause crippling lameness and painful arthritis of the joints. Derfuss is the only doctor in the area who has been certified by MediVet America to perform this double procedure. The stem cell procedure is an affordable and non-invasive alternative to FHO (femoral head osteopathy) surgery, which was originally planned for Auggie.

Chloe is a beautiful 11 year old golden retriever who suffers from bilateral arthritic hips and long term inflammation issues. It was decided to use this new technology to treat Chloes ailments as an alternative to expensive and invasive hip replacement surgery.

Follow this link:
First ever double stem cell therapy procedure to be performed by Branchburg veterinarian

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Are stem cells the best way to repair cartilage? – Video

February 22nd, 2013 3:47 am


Are stem cells the best way to repair cartilage?
http://www.stemcellsarthritistreatment.com How do you repair cartilage... isn #39;t that the $64 question? In this video I #39;m going to tell you why chondrocytes- cartilage cells- aren #39;t the best way to make new cartilage. Chondrocytes are cells that normally reside in cartilage. You would think they would be a good source. There are problems with this line of thought. First, there are different types of cartilage. For example, ear cartilage is different from knee cartilage. Ear cartilage is elastic cartilage while knee cartilage is stronger hyaline cartilage. The other problem is that chondrocytes, when cultured, lose what is called their phenotype. In other words, chondrocytes from hyaline cartilage undergo chemical changes and begin to transform into other softer kinds of cartilage. Not good. it appears that mesenchymal stem cells might be a much better alternative for repairing cartilage. http

By: Nathan Wei

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Are stem cells the best way to repair cartilage? - Video

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Are stem cells better than chondrocytes for making cartilage? – Video

February 22nd, 2013 3:47 am


Are stem cells better than chondrocytes for making cartilage?
http://www.stemcellsarthritistreatment.com Are mesenchymal stem cells better than chondrocytes for making cartilage? Mesenchymal stem cells are easy to obtain and proliferate-multiply- rapidly, given the right growth factors. They can be found in bone marrow, muscle, fat, periosteum, umbilical cord blood, synovium, and placenta. They can be coaxed into becoming a number of different types of tissue including muscle, cartilage, and bone. Besides escaping from the immune regulation of the host, they also have immunoregulatory effects. Multiple studies have shown their ability to differentiate into good quality cartilage. http

By: Nathan Wei

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Are stem cells better than chondrocytes for making cartilage? - Video

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Banking stem cells from baby teeth – Video

February 22nd, 2013 3:47 am


Banking stem cells from baby teeth
From WGAL News, 2007

By: Maria Meliton

Visit link:
Banking stem cells from baby teeth - Video

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Kae Sahaye Stem Cells – Video

February 22nd, 2013 3:47 am


Kae Sahaye Stem Cells
York Pre Ap lit

By: ksahaye

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Kae Sahaye Stem Cells - Video

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New Study at the Center for Regenerative Medicine – Mayo Clinic – Video

February 20th, 2013 10:41 pm


New Study at the Center for Regenerative Medicine - Mayo Clinic
The Center for Regenerative Medicine at Mayo Clinic investigates what advances of stem cell biology would be useful to apply in the treatment of patients with end stage diseases. Jorge Rakela, MD, associate director for the Center, provides an overview of the Center which is also involved in a tissue engineering program with Arizona State University. Jeffery Cornella, MD, a gynecological surgeon at Mayo Clinic, and Johnny Yi, MD, a surgical fellow at Mayo Clinic, talk about a study underway to develop new tissue to aid in the treatment of vaginal prolapse and other conditions.

By: mayoclinic

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New Study at the Center for Regenerative Medicine - Mayo Clinic - Video

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Stem Cell Therapy – Arthritis Therapy – Video

February 19th, 2013 1:44 pm


Stem Cell Therapy - Arthritis Therapy
Stem cell therapy for dogs, cats, and horses has been around for a few years. But as companies compete, the technology keeps improving. And today, a Hillsborough County vet clinic became only the second in the Bay Area to offer same-day procedures.

By: EhrlichAnimalHospita

Originally posted here:
Stem Cell Therapy - Arthritis Therapy - Video

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Stem Cell Therapy – Ehrlich Animal Hospital’s Arthritis Therapy Center – Video

February 19th, 2013 1:44 pm


Stem Cell Therapy - Ehrlich Animal Hospital #39;s Arthritis Therapy Center
Ehrlich Animal Hospital offers several degrees of specialty arthritis therapies and treatments that may not be currently available at other local animal hospitals. Our hospital is unique in that we offer cutting edge arthritis therapy technologies: therapeutic laser treatments, injectable medications and oral medications to reduce inflammation and discomfort.

By: EhrlichAnimalHospita

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Stem Cell Therapy - Ehrlich Animal Hospital's Arthritis Therapy Center - Video

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Learn more about stem cell therapy at Vail Athletic Club Friday

February 19th, 2013 1:44 pm

VAIL The Vail Athletic Club, part of the Vail Vitality Center wellness experience at Vail Mountain Lodge, introduces a lecture which offers an in-depth look at new developments in cellular therapy for the treatment of joint pain. Stem Cell Therapy is a groundbreaking procedure that uses a patient's own stem cells to repair or replace damaged joint tissue. Dr. Scott Brandt of ThriveMD in Edwards is one of few physicians in the country trained in this procedure. Brandt will present details about this innovative new therapy at the Vail Athletic Club on Friday at 6 p.m.

Stem cell therapy is a minimally invasive procedure that begins with harvesting a patient's stem cells from his or her own fat reserves most often from the abdominal region. The tissue is isolated in a state-of-the-art cell-processing laboratory. The cells are then injected into the damaged joint using a minimally invasive technique with the assistance of fluoroscopic guidance. Once injected, the cells can sense proteins generated from cartilage damage and, in response, those cells have the ability to make chondrocytes cells found in healthy cartilage. This new procedure relieves the pain and limitations of arthritic joint disease without resorting to an invasive joint replacement surgery.

Brandt will discuss the process of isolating autologous adipose derived stem cells, the details of the procedure, and answer questions about this treatment for cartilage, ligament and tendon injuries.

For more information or to register call 970-476-7960. The lecture is offered as a fundraiser for the Eagle County Education Foundation and a $15 donation is suggested. Advance reservations are required and space is limited.

See the article here:
Learn more about stem cell therapy at Vail Athletic Club Friday

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Induced pluripotent stem cells – Video

February 18th, 2013 12:44 pm


Induced pluripotent stem cells

By: sk18

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Induced pluripotent stem cells - Video

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Jeunesse – LUMINESCE – What are, and how we use, Stem Cells – Video

February 18th, 2013 12:44 pm


Jeunesse - LUMINESCE - What are, and how we use, Stem Cells
To know more about the product, visit http://www.kenny888.jeunesseglobal.com

By: Kenny Tean

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Jeunesse - LUMINESCE - What are, and how we use, Stem Cells - Video

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Hypoxic Ischaemic Brain Injury Improvement After Stem Cell Therapy in Mumbai India – Video

February 18th, 2013 12:43 pm


Hypoxic Ischaemic Brain Injury Improvement After Stem Cell Therapy in Mumbai India
He is a case of Hypoxic Brain Injury since 4 years. Because of high grade fever of "chikungunya", he got cardiac arrest and went into coma for 1 year. During comatose stage, he had sacral and Greater Trochanter sores which are all recovered and he has developed myositis ossification at bilateral hip and right elbow. Hip myositis ossification was removed surgically. After comatose stage, he has recovered in speech and voluntary control. He has developed rigidity in trunk and lower extremities. In 2011,he had history of fall while walking and had right femur shaft fracture which was treated surgically with plate and screws in place. Neurologically, he is hypertonic and hyperreflexic. On examination, he has restricted range of motion of bilateral hip, knee and ankle and right elbow. Voluntary control of lower extremities is poor while voluntary control of upper extremities is fair. He has rigidity in bilateral lower extremities and spasticity of grade 2 in upper extremities muscles. Patient is dependent for all ADL. On FIM he scores 30. After Stem Cell Treatment 1. He feels ease in getting up from supine to sit. 2. He can sit straight for some time (5-10 minutes) ,earlier easily stoop in 5-10 seconds. 3. His sitting balance is improved than before, earlier had fear to tilt sideways. 4. His spasticity in lower limb has reduced. 5. His speech has become clear and with proper pauses. 6. He can do roll over on bed with ease and less assistance from caretaker than before. Stem ...

By: neurogenbsi

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Hypoxic Ischaemic Brain Injury Improvement After Stem Cell Therapy in Mumbai India - Video

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Inclusive Body Myopathy Improvement After Stem Cell Therapy in Mumbai India – Video

February 18th, 2013 12:43 pm


Inclusive Body Myopathy Improvement After Stem Cell Therapy in Mumbai India
He is a case of Inclusive Body Myopathy, since last 16 years with the history of slowness in running speed and slipping of "chappals" while walking and following foot drop. Weakness is progressive in nature and now involved muscles of all 4 limbs and trunk. Since last 3 years he is bedridden. Muscle biopsy is showing Inclusive Body Myopathy and EMG-NCV reports are showing generalized primary muscle disease. His elder sister also suffering from the same problem. Neurologically, he is hypotonic and hyporeflexic. On examination: he has grade 1+ muscle power in all 4 limbs proximally and grade 0 foot muscles and grade 3 distal muscles of upper limbs. Proximal muscle weakness is more than distal. Functionally, he is dependent in all ADL and mobility. On FIM he scores 48. After Stem Cell Treatment 1. Stamina has increased. 2. He can do suspension exercises for more range of motion and with more repetition without fatigue. 3. Now he can initiate rolling. He takes less support for rolling and turning. Earlier he used to change his position 4-5 times because of discomfort, but now he needs to change his position only once at night. 4. He can initiate supine to sit. 5. He is able to perform side lying to sitting by himself upto 70%. 6. Attempted drinking water in modified manner with right hand, which he couldn #39;t do before. Stem Cell Therapy done at Dr Alok Shrama NeuroGen Brain and Spine Institute Surana Sethia Hospital Sion-Trombay Rd, Suman Ngr Opp Corporate Park, Chembur ...

By: neurogenbsi

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Inclusive Body Myopathy Improvement After Stem Cell Therapy in Mumbai India - Video

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Testimonials – Stem Cell Therapy – Ehrlich Animal Hospital’s Arthritis Therapy Center – Video

February 18th, 2013 12:43 pm


Testimonials - Stem Cell Therapy - Ehrlich Animal Hospital #39;s Arthritis Therapy Center
We love your pets and we know that you do too. Let us ensure that your pets live the longest, healthiest lives possible. Thank you for your continued confidence in our love and concern for your pet #39;s health and longevity.

By: EhrlichAnimalHospita

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Testimonials - Stem Cell Therapy - Ehrlich Animal Hospital's Arthritis Therapy Center - Video

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