TWIS Minion / Science Island Hangout - May 1, 2014
Ed Dyer, Ulysses Adkins and Jani Turunen talking about Ganymede #39;s "club sandwich" oceans, NASA #39;s space life rafts, stem cells therapy regenerating heart muscles, blood and cartilage. Show...
By: Edward Dyer
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TWIS Minion / Science Island Hangout - May 1, 2014 - Video
PUBLIC RELEASE DATE:
1-May-2014
Contact: Mary Beth O'Leary moleary@cell.com 617-397-2802 Cell Press
Researchers reporting in the Cell Press journal Cell Reports on May 1st have successfully coaxed stem cells made from the skin cells of infertile men into producing sperm cell precursors. These induced pluripotent stem cells (iPSCs) produced sperm precursors following transplantation into the testes of mice.
The findings help to explain a genetic cause of male infertility and offer a window into basic sperm biology. The approach also holds considerable potential for clinical application, the researchers say.
"Our results are the first to offer an experimental model to study sperm development," said Renee Reijo Pera of the Institute for Stem Cell Biology & Regenerative Medicine and Montana State University. "Therefore, there is potential for applications to cell-based therapies in the clinic, for example, for the generation of higher quality and numbers of sperm in a dish.
"It might even be possible to transplant stem-cell-derived germ cells directly into the testes of men with problems producing sperm," she added. However, getting to that point will require considerable study to ensure the safety and practicality.
Infertility affects 10% to 15% of couples. Moreover, as the researchers note, genetic causes of infertility are surprisingly prevalent among men, most commonly due to the spontaneous loss of key genes on the Y sex chromosome. But the causes at the molecular level have not been well understood.
Reijo Pera said her primary motivation is to understand the fundamental decision early in development that enables the production of sperm cell precursors and ultimately sperm. One way to do that is to study cells lacking genes that are required for sperm production.
The researchers looked to infertile but otherwise normal men with deletions encompassing three Y chromosome azoospermia factor (AZF) regions, which are associated with the production of few or no sperm. They found that iPSCs derived from AZF-deleted cells were compromised in their ability to form sperm in a dish. But when those cells were transplanted into the seminiferous tubules of mice, they produced germ-cell-like cells (though significantly fewer than iPSCs derived from people without the AZF deletion do).
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Sperm precursors made from stem cells of infertile men
Heart cells created from human embryonic stem cells successfully restored damaged heart muscles in monkeys.
The results of the experiment appear in the April 30 advanced online edition of the journal Nature in a paper titled, "Human embryonic-stem cell derived cardiomyocytes regenerate non-human primate hearts."
The findings suggest that the approach should be feasible in humans, the researchers said.
"Before this study, it was not known if it is possible to produce sufficient numbers of these cells and successfully use them to remuscularize damaged hearts in a large animal whose heart size and physiology is similar to that of the human heart," said Dr. Charles Murry, UW professor of pathology and bioengineering, who led the research team that conducted the experiment.
A physician/scientist, Murry directs the UW Center for Cardiovascular Biology and is a UW Medicine pathologist.
Murry said he expected the approach could be ready for clinical trials in humans within four years.
In the study, Murry, along with Dr. Michael Laflamme and other colleagues at the UW Institute for Stem Cell & Regenerative Medicine, experimentally induced controlled myocardial infarctions, a form of heart attack, in anesthetized pigtail macaques.
The infarcts were created by blocking the coronary artery of macaque for 90 minutes, an established model for the study of myocardial infarction in primates.
In humans, myocardial infarctions are typically caused by coronary artery disease. The resulting lack of adequate blood flow can damage heart muscle and other tissues by depriving them of oxygen. Because the infarcted heart muscle does not grow back, myocardial infarction leaves the heart less able to pump blood and often leads to heart failure, a leading cause of cardiovascular death.
The goal of stem cell therapy is to replace the damaged tissue with new heart cells and restore the failing heart to normal function.
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Stem cell therapy regenerates heart muscle damaged from heart attacks in primates
Stem Cells - The Ultimate Smart Cell: Assoc. Prof. Ben Herbert
Regeneus presented a stem cell information evening at The Kings School on February 18th 2014. The evening, titled Stem Cells - The Ultimate Smart Cell, featu...
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Stem Cells - The Ultimate Smart Cell: Assoc. Prof. Ben Herbert - Video
From Stem Cells To Cancer Cells
Fernando Camargo discusses his research on how cancer arises, what can be done to stop it, and whether cancer is related to stem cells. The human stem cells ...
By: Forum Network
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From Stem Cells To Cancer Cells - Video
Diabetes cure? Cloned human stem cells could provide the answer
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Diabetes cure? Cloned human stem cells could provide the answer - Video
(MENAFN - Arab News) The king abdullah international medical research center (kaimrc) recently joined a conference on stem cell research and its application science and medicine the saudi press agency reported.
the conference which was organized by the health affairs at the national guard unveiled the latest discoveries and findings made by researchers at the stem cell and regenerative medicine unit at kaimrc the agency said.
the conference was attended by several experts on stem cell research representing saudi arabia the united states britain france sweden italy australia and new zealand.
ahmed al-askar ceo of kaimrc said stem cell research is a broad topic that sheds light on how to best exploit human cells to treat diseases for certain organs such as the liver kidney or nerves.
he said the current use of stem cells is centered on plantation for the treatment of certain types of leukemia cancer and genetic diseases.
since its inception three years ago the center has transplanted 200 cells following the creation of a program for transplanting stem cells in children and adults he said.
saudi arabia has the sole stem cell donation registry in arab countries compared with 60 cells donation registries globally he said.
'the saudi stem cell donation center is meant to attract potential donors from arab countries" he said. 'we have had 5000 donors so far."
he said some 400 scientists and experts are working at the center while another 40 physicians have been dispatched on scholarships to acquire training and specialization.
al-askar expressed optimism over the future of stem cell use and its contribution to the treatment of a variety of diseases such as diabetes cancer pulmonary and hepatic fibrosis and neurological and cardiovascular disorders.
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Saudi- Conference to shed light on latest stem cell applications
The King Abdullah International Medical Research Center (KAIMRC) recently joined a conference on stem cell research and its application science and medicine, the Saudi Press Agency reported. The conference, which was organized by the Health Affairs at the National Guard, unveiled the latest discoveries and findings made by researchers at the stem cell and regenerative medicine unit at KAIMRC, the agency said. The conference was attended by several experts on stem cell research representing Saudi Arabia, the United States, Britain, France, Sweden, Italy, Australia and New Zealand. Ahmed Al-Askar, CEO of KAIMRC, said stem cell research is a broad topic that sheds light on how to best exploit human cells to treat diseases for certain organs, such as the liver, kidney or nerves. He said the current use of stem cells is centered on plantation for the treatment of certain types of leukemia, cancer and genetic diseases. Since its inception three years ago, the center has transplanted 200 cells following the creation of a program for transplanting stem cells in children and adults, he said. Saudi Arabia has the sole stem cell donation registry in Arab countries, compared with 60 cells donation registries globally, he said. The Saudi stem cell donation center is meant to attract potential donors from Arab countries, he said. We have had 5,000 donors so far. He said some 400 scientists and experts are working at the center, while another 40 physicians have been dispatched on scholarships to acquire training and specialization. Al-Askar expressed optimism over the future of stem cell use and its contribution to the treatment of a variety of diseases, such as diabetes, cancer, pulmonary and hepatic fibrosis and neurological and cardiovascular disorders.
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Conference to shed light on latest stem cell applications
Stem cell therapy | irish stem cells
http://www.arthritistreatmentcenter.com So what #39;s going on in Ireland when it comes to arthritis... coming up next... First signs of arthritis cure seen by Irish researchers The first signs...
By: Nathan Wei
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Stem cell therapy | irish stem cells - Video
PUBLIC RELEASE DATE:
29-Apr-2014
Contact: Jennifer Beal sciencenewsroom@wiley.com 44-124-377-0633 Wiley
Stem cell therapies work as a complement to standard treatments, potentially cutting the number of deaths after a year, suggests evidence from the latest Cochrane review: Stem cell therapy for chronic ischaemic heart disease and congestive heart failure. Taking stem cells from a patient's bone marrow and injecting them into their damaged heart may be an effective way to treat heart disease.
The new review, published today in The Cochrane Library, uses data involving 1,255 people from 23 randomised controlled trials, where all participants received standard treatments. Compared to standard treatment alone or with placebo, stem cell therapy using bone marrow cells resulted in fewer deaths due to heart disease and heart failure, reduced the likelihood of patients being readmitted to hospital, and improved heart function. However, researchers say that with much larger clinical trials underway, the findings are awaited to enable more certainty about the effects.
Dr Enca Martin-Rendon, author of the review, Cochrane Heart Review Group, and based at NHS Blood and Transplant and the University of Oxford, UK, said: "This is encouraging evidence that stem cell therapy has benefits for heart disease patients. However, it is generated from small studies and it is difficult to come to any concrete conclusions until larger clinical trials that look at longer- term effects are carried out."
Stem cell therapies are experimental treatments that are currently only available in facilities carrying out medical research. If eventually found to be effective, they might offer an alternative or complementary treatment to standard drug and surgical treatments for some patients with chronic heart disease. The procedure involves collecting stem cells from a patient's own blood or bone marrow and using them to repair damaged tissues in the patient's heart and arteries.
Although within the first year there were no clear benefits of stem cell therapy over standard treatment alone, when longer term data were analysed a year or more later about 3 per cent of people treated with their stem cells had died compared with 15 per cent of people in the control groups. Hospital readmissions were reduced to 2 in every 100 people compared to 9 in the control group, and adverse effects were rare.
Dr Martin-Rendon continued, "It isn't clear which types of stem cells work best or why stem cell therapies seem to work for some people but not for others. We need to find out what's different in the people who aren't responding well to these treatments as it might then be possible to tailor therapies to these patients, so that they work better."
Dr David Tovey, Editor-in-Chief, Cochrane, said: "This review should help to raise awareness of the potential of stem cell therapy to improve patient outcomes, but it also demonstrates the importance of recognising the uncertainty of initial findings and the need for further research. A Cochrane review aims to analyse all available data to give a clear picture of what the evidence shows. Ensuring health decision makers, health professionals and the general public has access to up-to-date, relevant evidence research will help to raise awareness of the effectiveness of treatments and medications and therefore improve health care."
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Stem cell therapies look promising for heart disease
New York, NY (PRWEB) April 29, 2014
The Stem Cell Institute located in Panama City, Panama, welcomes special guest speaker Roberta F. Shapiro, DO, FAAPM&R to its public seminar on umbilical cord stem cell therapy on Saturday, May 17, 2014 in New York City at the New York Hilton Midtown from 1:00 pm to 4:00 pm.
Dr. Shapiro will discuss A New York Doctors Path to Panama.
Dr. Shapiro operates a private practice for physical medicine and rehabilitation in New York City. Her primary professional activities include outpatient practice focused on comprehensive treatment of acute and chronic musculoskeletal and myofascial pain syndromes using manipulation techniques, trigger point injections, tendon injections, bursae injections, nerve and motor point blocks. Secondary work at her practice focuses on the management of pediatric onset disability.
She is the founder and president of the Dayniah Fund, a non-profit charitable foundation formed to support persons with progressive debilitating diseases who are faced with catastrophic events such as surgery or illness. The Dayniah Fund educates the public about the challenges of people with disabilities and supports research on reducing the pain and suffering caused by disabling diseases and conditions.
Dr. Shapiro serves as assistant clinical professor in the Department of Rehabilitation and Regenerative Medicine at Columbia University Medical Center.
Stem Cell Institute Speakers include:
Neil Riordan PhD Clinical Trials: Umbilical Cord Mesenchymal Stem Cell Therapy for Autism and Spinal Cord Injury
Dr. Riordan is the founder of the Stem Cell Institute and Medistem Panama Inc.
Jorge Paz-Rodriguez MD Stem Cell Therapy for Autoimmune Disease: MS, Rheumatoid Arthritis and Lupus
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Stem Cell Institute Welcomes Special Guest Speaker Roberta F. Shapiro DO, FAAPM&R to Stem Cell Therapy Public Seminar ...
Phoenix, Arizona (PRWEB) April 28, 2014
Center for Joint Regeneration is now offering stem cell procedures for nonoperative rotator cuff repair with Board Certified orthopedic doctors. The regenerative medicine procedures are performed as an outpatient and involve either bone marrow derived or amniotic derived stem cell material. Call (480) 466-0980 for more information and scheduling.
Millions of Americans are affected by shoulder pain due to a rotator cuff bursitis or tendon tear. The pain may persist for months and may end up needing surgery if traditional treatments fail. These may include steroid injections, physical therapy and pain medication.
Treatment with regenerative medicine has now become available with stem cell material. The Board Certified orthopedic doctors at Center for Joint Regeneration offer stem cell procedures for rotator cuff injuries with either bone marrow or amniotic derived stem cells.
The bone marrow stem cells involve harvesting the material in a short procedure from the patient, with immediate processing to concentrate the stem cells and growth factors for injection into the shoulder. The amniotic material is obtained from consenting donors after a scheduled c-section procedure. There is no fetal tissue used at all, alleviating any ethical concerns.
Small studies to date have shown stem cell procedures to work well for pain relief and restoration of function with musculoskeletal conditions such as knee arthritis, ligament injury and tendonitis. The stem cell material includes growth factors, stem cells, hyaluronic acid and anti-inflammatory medicine as well.
Center for Joint Regeneration also offers stem cell procedures for joint arthritis, ligament injuries and tendonitis of other areas of the body as well. This helps patients avoid surgery as well as helping athletes return to sporting activities.
For more information and scheduling to discuss regenerative medicine stem cell procedure options, call (480) 466-0980.
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Center for Joint Regeneration in Phoenix Now Offering Stem Cell Procedures for Nonoperative Rotator Cuff Tendon Repair
Stem Cell Therapy | Genetics and Rheumatoid Arthritis
What do genes have to do with arthritis? No... not those kinds of genes... these kinds of jeans. Genetics can explain why infections can trigger rheumatoid arthritis Appearing in Science Codex...
By: Nathan Wei
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Stem Cell Therapy | Genetics and Rheumatoid Arthritis - Video
Purtier Deer Placenta - Stem Cell Therapy
Increasingly hectic lifestyles, bad dietary habits, stress and pollution take a toll on our bodies. As we age, metabolic syndromes and cardiovascular diseases will surface. High blood pressure,...
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Purtier Deer Placenta - Stem Cell Therapy - Video
PUBLIC RELEASE DATE:
28-Apr-2014
Contact: Franca Davenport f.davenport@imperial.ac.uk 020-759-42198 Imperial College London
New research looking at the success of clinical trials of stem cell therapy shows that trials appear to be more successful in studies where there are more discrepancies in the trial data.
Researchers from Imperial College London conducted a meta-analysis of 49 randomised controlled trials of bone marrow stem cell therapy for heart disease. The study, published today in the British Medical Journal, identified and listed over 600 discrepancies within the trial reports.
Discrepancies were defined as two (or more) reported facts that could not both be accurate because they were logically or mathematically incompatible. For example, one trial reported that it involved 70 patients, who were divided into two groups of 35 and 80.
The researchers found eight trials that each contained over 20 discrepancies.
The researchers found that the discrepancy count in a trial was the most important determinant of the improvement in cardiac function reported by that trial. Trials with fewer and fewer discrepancies showed progressively smaller improvements in cardiac function. The five trials with no discrepancies at all showed an effect size of zero (see bar chart in Notes to Editors).
Previous meta-analyses looking at the results of lots of clinical trials have suggested that on average, bone marrow stem cell therapy has a significant positive effect on improving heart function. However, some trials have shown that it successfully improves heart function whilst others have not. The reasons for this are unclear.
Professor Darrel Francis, one of the study authors from the National Heart and Lung Institute at Imperial College London, said: "Clinical trials involve a huge amount of data and so it is understandable that discrepancies sometimes arise when researchers are presenting their findings. However, our study suggests that these discrepancies can have a significant impact on the overall results. It is a powerful reminder to all of us conducting clinical trials to be careful and vigilant to avoid discrepancies appearing in the work.
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Study of stem cell trials links discrepancies in data with reported success of treatment
Homeopathic Remedies Made From Stem Cells
Dr. Michael Martins recommends to buy Homeopathic Remedies made by their company from stem cells (Modern Homeopathy - http://herballabs.net/en/homeopathy/mod...
By: Lidija Skolnija
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Homeopathic Remedies Made From Stem Cells - Video
Stem Cells - The Ultimate Smart Cell: Professor Brian Ford
Regeneus presented a stem cell information evening at The Kings School on February 18th 2014. The evening, titled Stem Cells - The Ultimate Smart Cell, featured presentations from Professor...
By: Regeneus Ltd
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Stem Cells - The Ultimate Smart Cell: Professor Brian Ford - Video
Stem Cells - by Wideo.co
This online video was created and exported from http://www.wideo.co ********************...
By: Meghan Root
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Stem Cells - by Wideo.co - Video
MS Life Day 02 Full Live Stream
Featuring: 11am - 12pm: Myelin repair 12.30 - 1.30pm: Stem cells 2 - 3pm: Fatigue research.
By: MS Society
Treatment for Diabetes - with Stem cells
Emcell clinic.
By: Andrew Leonidow
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Treatment for Diabetes - with Stem cells - Video