Dr. Chris Centeno Explains Regenexx vs. the FDA
Regenexx founder Dr. Chris Centeno discusses the FDA #39;s stance on cultured stem cells and how the same-day procedures performed in the United States by Regenexx and the Regenexx Physician Network...
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Dr. Chris Centeno Explains Regenexx vs. the FDA - Video
Stem Cell Research | Stem Cell Nutrition | Stem Cells
Adult Stem Cell Science in a Nutshell http://stemnutrition.com Adult Stem Cells are the body #39;s natural healing and renewal system. They are created by the bone marrow. When a tissue or organ...
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Stem Cell Research | Stem Cell Nutrition | Stem Cells - Video
Low power lasers and stem cells
Interview by Al Jazeera for the work published in Science and Translational Medicine 2014. Courtesy: Mr. Tareek Bazely.
By: Praveen Arany
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Low power lasers and stem cells - Video
Can heart attack damage be reversed?
Dr. Sanjay Gupta explores whether stem cells can help regrow dead cardiac tissue after a heart attack.
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Can heart attack damage be reversed? - Video
Tuesday 07/15: Dangerous Additives in Beer? Stem Cell Therapy; Summer Health Tips - Show Promo
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Tuesday 07/15: Dangerous Additives in Beer? Stem Cell Therapy; Summer Health Tips - Show Promo - Video
For breast cancer patients, the era of personalized medicine may be just around the corner, thanks to recent advances by USC Stem Cell researcher Min Yu and scientists at Massachusetts General Hospital and Harvard Medical School.
In a July 11 study in Science, Yu and her colleagues report how they isolated breast cancer cells circulating through the blood streams of six patients. Some of these deadly cancer cells are the "seeds" of metastasis, which travel to and establish secondary tumors in vital organs such as the bone, lungs, liver and brain.
Yu and her colleagues managed to expand this small number of cancer cells in the laboratory over a period of more than six months, enabling the identification of new mutations and the evaluation of drug susceptibility.
If perfected, this technique could eventually allow doctors to do the same: use cancer cells isolated from patients' blood to monitor the progression of their diseases, pre-test drugs and personalize treatment plans accordingly.
In the six estrogen receptor-positive breast cancer patients in the study, the scientists found newly acquired mutations in the estrogen receptor gene (ESR1), PIK3CA gene and fibroblast growth factor receptor gene (FGFR2), among others. They then tested either alone or in combination several anticancer drugs that might target tumor cells with these mutations and identified which ones merit further study. In particular, the drug Ganetspib -- also known as STA-9090 -- appeared to be effective in killing tumor cells with the ESR1 mutation.
"Metastasis is the leading cause of cancer-related death," said Yu, assistant professor in the Department of Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine of USC. "By understanding the unique biology of each individual patient's cancer, we can develop targeted drug therapies to slow or even stop their diseases in their tracks."
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The above story is based on materials provided by University of Southern California - Health Sciences. The original article was written by Cristy Lytal. Note: Materials may be edited for content and length.
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Stem cell researcher targets 'seeds' of breast cancer ...
How safe is stem cell therapy for children affected with autism spectrum disorder
In conversation with Dr Alok Sharma (MS, MCh.) Professor of Neurosurgery Head of Department, LTMG Hospital LTM Medical College, Sion, Mumbai. Explains, How safe is stem cell therapy for...
By: Neurogen Brain and Spine Institute
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Stem Cells and Alzheimer #39;s Disease - On Our Mind
Visit: http://www.uctv.tv/) Can stem cells be a weapon in the fight against Alzheimer #39;s disease? Larry Goldstein, PhD director the the UC San Diego Stem Cel...
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The Hope and Promise of Stem Cells | Len Zon | TEDxLongwood
This talk was given at a local TEDx event, produced independently of the TED Conferences. Imagine being able to reprogram the cells from a piece of skin and transform them into cells that can...
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The Hope and Promise of Stem Cells | Len Zon | TEDxLongwood - Video
For breast cancer patients, the era of personalized medicine may be just around the corner, thanks to recent advances by USC Stem Cell researcher Min Yu and scientists at Massachusetts General Hospital and Harvard Medical School.
In a July 11 study in Science, Yu and her colleagues report how they isolated breast cancer cells circulating through the blood streams of six patients. Some of these deadly cancer cells are the "seeds" of metastasis, which travel to and establish secondary tumors in vital organs such as the bone, lungs, liver and brain.
Yu and her colleagues managed to expand this small number of cancer cells in the laboratory over a period of more than six months, enabling the identification of new mutations and the evaluation of drug susceptibility.
If perfected, this technique could eventually allow doctors to do the same: use cancer cells isolated from patients' blood to monitor the progression of their diseases, pre-test drugs and personalize treatment plans accordingly.
In the six estrogen receptor-positive breast cancer patients in the study, the scientists found newly acquired mutations in the estrogen receptor gene (ESR1), PIK3CA gene and fibroblast growth factor receptor gene (FGFR2), among others. They then tested either alone or in combination several anticancer drugs that might target tumor cells with these mutations and identified which ones merit further study. In particular, the drug Ganetspib -- also known as STA-9090 -- appeared to be effective in killing tumor cells with the ESR1 mutation.
"Metastasis is the leading cause of cancer-related death," said Yu, assistant professor in the Department of Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine of USC. "By understanding the unique biology of each individual patient's cancer, we can develop targeted drug therapies to slow or even stop their diseases in their tracks."
Story Source:
The above story is based on materials provided by University of Southern California - Health Sciences. The original article was written by Cristy Lytal. Note: Materials may be edited for content and length.
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Stem cell researcher targets 'seeds' of breast cancer metastasis
Is there Scientific Evidence of How Stem Cell Therapy work in Autism Spectrum Disorder?
Dr. Hemangi Sane from Neurogen Brain and Spine Institute show Scientific Evidence of How Stem Cell Therapy work in Autism Spectrum Disorder. Published Paper on Autism Spectrum Disorder http://stem...
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Is there Scientific Evidence of How Stem Cell Therapy work in Autism Spectrum Disorder? - Video
Bench to Bedside: Mesenchymal Stem Cells and ARDS, Part 2 - Michael Matthay
http://www.ibiology.org/ibioeducation/taking-courses/bench-to-bedside/mesenchymal-stem-cells-acute-respiratory-distress-syndrome.html In Part 1, Dr. Calfee b...
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Professor Alexander Seifalian explains stem cell technique"
Professor Alexander Seifalian explains stem cell technique"However, last year, eight years after the stem cell operation, the woman, then 28, ... Professor Alexander Seifalian explains stem...
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Professor Alexander Seifalian explains stem cell technique" - Video
Insight: Stem Cells promo
Australians are getting a number of unproven stem cell treatments at home and abroad. Many patients claim the therapies are changing their lives for the bett...
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Insight: Stem Cells promo - Video
Im not betting on it, but if, by some miracle, Argentine winger Angel Di Maria is on the pitch against Germany Sunday in the 2014 World Cup final, get ready for another explosion of interest in stem cell therapy, a now familiar occurrence every time a famous athlete undergoes the treatment.
Di Maria, who either tore or strained a thigh muscle in Argentinas World Cup win over Belgium, is so determined to play in the final that, according to some reports, he is having the muscle injected with stem cells in the hope of healing by Sunday. (This Associated Press report from Thursday said he was practicing at 60 to 80 percent, so Im guessing were talking about a strain.)
If those reports are true, Di Maria will join a long line of elite athletes who have resorted to the unproven and possibly risky therapy. This kind of stem cell therapy is experimental in every sense of the word, according to the International Society for Stem Cell Research. There also is some evidence that the procedure can promote tumor growth or create an immune response to a patients own cells, or that injected stem cells might migrate to another part of the body.
Never mind. There is soccer to be played!
No one denies that stem cells hold promise as a therapy down the road, perhaps in as little as five or 10 years, says Kevin McCormack, communication director for the California Institute for Regenerative Medicine. With $3 billion supplied by voters in a 2004 ballot initiative, the organization is funding trials of the use of stem cell therapies for scarring after heart attacks, sickle cell anemia, leukemia and other conditions.
But for now, stem cells are known to be effective only for certain disorders of the blood, immune system and bone marrow. Beyond that, little has been proven, although clinics in the United States and around the world are offering the therapy and raking in bucks from desperate patients.
Di Maria may even see some benefits, McCormack said. In theory, they might [help] because they may have an anti-inflammatory effect or they may stimulate the bodys own natural healing, he said. But the problem is that they havent done any research to prove that.
The stem cells are harvested from a patients bone marrow and sometimes run through a centrifuge to concentrate them. Then they are injected into the damaged tissue.
For athletes, who are always looking for ways to prolong their careers and bounce back from injury, the fad began in 2010, when Major League pitcher Bartolo Colon had a slurry of stem cells that can turn into a variety of tissues injected into his injured elbow and shoulder. Within months, he was throwing 93 mile per hour fastballs for the New York Yankees. Later, Denver Broncos quarterback Peyton Manning, one of the most famous athletes in the United States, reportedly had stem cell therapy on his injured neck.
McCormack and others express concern that when pro athletes and other celebrities have unproven treatments, it sends the rest of us weekend warriors out in search of the same. Here a good bit of blame goes to us in the media. A 2012 analysis conducted for the journal Molecular Therapyshowed that 72.7 percen of the media coverage of athletes and stem cell therapy didnt address whether the treatment works, and 42 percent referred to alleged benefits. Only 5.7 percent of the stories brought up possible safety issues and risks.
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Injured Argentine winger Angel Di Maria may be resorting to unproven stem cell therapy
PUBLIC RELEASE DATE:
11-Jul-2014
Contact: Jia Liu liujia@genomics.cn BGI Shenzhen
July 3, 2014, Shenzhen, China Researchers from Salk Institute for Biological Studies, BGI, and other institutes for the first time evaluated the safety and reliability of the existing targeted gene correction technologies, and successfully developed a new method, TALEN-HDAdV, which could significantly increased gene-correction efficiency in human induced pluripotent stem cell (hiPSC). This study published online in Cell Stell Cell provides an important theoretical foundation for stem cell-based gene therapy.
The combination of stem cells and targeted genome editing technology provides a powerful tool to model human diseases and develop potential cell replacement therapy. Although the utility of genome editing has been extensively documented, but the impact of these technologies on mutational load at the whole-genome level remains unclear.
In the study, researchers performed whole-genome sequencing to evaluate the mutational load at single-base resolution in individual gene-corrected hiPSC clones in three different disease models, including Hutchinson-Gilford progeria syndrome (HGPS), sickle cell disease (SCD), and Parkinson's disease (PD).
They evaluated the efficiencies of gene-targeting and gene-correction at the haemoglobin gene HBB locus with TALEN, HDAdV, CRISPR/CAS9 nuclease, and found the TALENs, HDAdVs and CRISPR/CAS9 mediated gene-correction methods have a similar efficiency at the gene HBB locus. In addition, the results of deep whole-genome sequencing indicated that TALEN and HDAdV could keep the patient's genome integrated at a maximum level, proving the safety and reliability of these methods.
Through integrating the advantages of TALEN- and HDAdV-mediated genome editing, researchers developed a new TALEN-HDAdV hybrid vector (talHDAdV), which can significantly increase the gene-correction efficiency in hiPSCs. Almost all the genetic mutations at the gene HBB locus can be detected by telHDAdV, which allows this new developed technology can be applied into the gene repair of different kinds of hemoglobin diseases such as SCD and Thalassemia.
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A new genome editing method brings the possibility of gene therapies closer to reality
Keck Medicine of USC has acquired a small oncology network, Orange Coast Oncology Hematology, to expand its growing presence in Orange County.
Keck intends to change the name of the newly acquired network to USC Oncology/Hematology, which will operate out of offices in Newport Beach and Irvine.
Orange County cancer patients will now have access to university-based treatment, including clinical trials and genetic stem cell research, without having to drive to Los Angeles, said Thomas Jackiewicz, chief of Keck Medicine of USC.
The acquisition is part of Keck Medicines ongoing expansion into Orange County, Jackiewicz said. Keck Medicine has previously affiliated with Hoag Memorial Hospital Presbyterian in Newport Beach as part of its Orange County outreach.
We realized a lot of people were leaving Orange County for their cancer care, Jackiewicz said. We really wanted to make it about the patient and try to bring cancer care closer to home.
Under the acquisition, which was announced Wednesday, physicians with the former Orange Coast Oncology Hematology will become faculty at Keck School of Medicine. The physicians joining Keck include Greg Richard Angstreich, Minh D. Nguyen, George B. Semeniuk III, Dilruba Haque and Louis VanderMolen.
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Keck Medicine pushing into O.C. with oncology network acquisition
Tampa, FL (PRWEB) July 10, 2014
The Lung Institute works to help people who have received a diagnosis of debilitating lung disease get their quality of life back. The latest case study demonstrates how stem cell therapy can be used effectively to treat interstitial lung disease. After his recent stem cell treatment at the Lung Institute, Al Corter can now complete his daily tasks on his horse farm much faster, and finally attend the Silver Spur Riding Club Open Horse Show the weekend of July 12th in Fonda, NY.
Twelve years ago, Al was exposed to toxic fumes in the workplace and subsequently diagnosed with interstitial lung disease and bronchiectasis, a form of chronic obstructive pulmonary disorder (COPD). Living in upstate New York and running his horse farm, Als serious pulmonary conditions had a major effect on his life. Shortness of breath, coughing, reliance on supplemental oxygen and fatigue were taking a toll. Al needed a new solution.
Al decided to travel to Florida to undergo stem cell treatment at the Lung Institute facility in Tampa. He was seeking an alternative treatment to help with his symptoms. Stem cell therapy is a minimally invasive process that involves extracting stem cells, and then reintroducing them to cue the bodys natural healing processes. The stem cells are taken from the patients own body, so there is no controversy or risk of rejection.
Stem cell therapy is a viable option for many people with lung disease, said Dr. Burton Feinerman, Medical Director of the Lung Institute. Our patients are breathing easier, walking further and depending less on supplemental oxygen.
Prior to stem cell therapy, Al was needing more and more supplemental oxygen. His quality of life had taken a sharp turn downward. Following adipose stem cell treatment, Al is feeling better. He is getting back to the routine at the farm. Al used to use 5 to 6 liters of continuous oxygen to get his outdoor farm work done. Now, he is able to do these daily chores faster, and uses only 4 to 5 liters of oxygen on a pulsing regulator.
Im getting everyday tasks done quicker, said Al. Im using about half the amount of oxygen as I was before to do the same activities. My quality of life has definitely improved.
The Lung Institute has treated hundreds of patients with lung disease from around the country and the world. Regardless of the stage of the disease, patients are able to undergo stem cell therapy, which helps damaged lung tissue, and can lessen their symptoms.
About Lung Institute At the Lung Institute, we are changing the lives of hundreds of people across the nation through the innovative technology of regenerative medicine. We are committed to providing patients a more effective way to address pulmonary conditions and improve quality of life. Our physicians, through their designated practices, have gained worldwide recognition for the successful application of revolutionary minimally invasive stem cell therapies. With over a century of combined medical experience, our doctors have established a patient experience designed with the highest concern for patient safety and quality of care. For more information, visit our website at LungInstitute.com, like us on Facebook, follow us on Twitter or call us today at (855) 469-5864.
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Lung Institute Reveals New Stem Cell Therapy Case Study
Alan Trounson, then president of the California Institute for Regenerative Medicine, poses for a portrait at his offices in San Francisco, Monday, March 9, 2009. (AP Photo/Eric Risberg)
The former head of California's stem cell agency, which is handing out $3 billion of voter-approved funds for research, has joined the board of a major grant recipient one week after leaving his post.
Alan Trounson, the former president of the California Institute for Regenerative Medicine, has joined the board of StemCells Inc., the recipient of $19.4 million from the agency.
The agency has been grappling with potential conflicts of interest, some of which are built into its governance under Proposition 71, approved by voters in 2004. CIRM paid $700,000 for a report last year making recommendations on how to mitigate conflicts.
Trounson's move has reignited debate over the issue.
"The announcement raises serious and obvious concerns on a number of fronts," Chairman Jonathan Thomas wrote to his colleagues on the CIRM board. "Under state law, however, it is permissible for Dr. Trounson to accept employment with a CIRM-funded company. Nonetheless, state law does impose some restrictions on Dr. Trounsons post-CIRM employment activities.
Board members will be forbidden to discuss the company with Trounson for one year after his departure, Thomas wrote.
Randy Mills, Trounson's successor as agency president, said in a statement Wednesday that "in the interests of transparency and good governance we will be conducting a full review of all CIRM activities relating to StemCells Inc.
"We take even the appearance of conflicts of interest very seriously," Mills said in the statement.
Not only board members, but CIRM employees are being reminded of the conflict of interest rules.
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Stem cell boss joins board he funded
Research in sphere of stem cells
Research in the field of stem cells in Kazakhstan is a relatively a new science. However, experiments of National Research Medical Center allowed improving t...
By: Kazakh TV
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