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Cell discovery brings blood disorder cure closer

August 14th, 2014 8:41 pm

A cure for a range of blood disorders and immune diseases is in sight, according to scientists who have unravelled the mystery of stem cell generation.

The Australian study, led by researchers at the Australian Regenerative Medicine Institute (ARMI) at Monash University and the Garvan Institute of Medical Research, is published today in Nature. It identifies for the first time mechanisms in the body that trigger hematopoietic stem cell (HSC) production.

Found in the bone marrow and in umbilical cord blood, HSCs are critically important because they can replenish the body's supply of blood cells. Leukemia patients have been successfully treated using HSC transplants, but medical experts believe blood stem cells have the potential to be used more widely.

Lead researcher Professor Peter Currie, from ARMI explained that understanding how HSCs self-renew to replenish blood cells is a "Holy Grail" of stem cell biology.

"HSCs are one of the best therapeutic tools at our disposal because they can make any blood cell in the body. Potentially we could use these cells in many more ways than current transplantation strategies to treat serious blood disorders and diseases, but only if we can figure out how they are generated in the first place. Our study brings this possibility a step closer," he said.

A key stumbling block to using HSCs more widely has been an inability to produce them in the laboratory setting. The reason for this, suggested from previous research, is that a molecular 'switch' may also be necessary for HSC formation, though the mechanism responsible has remained a mystery, until now.

In this latest study, ARMI researchers observed cells in the developing zebra fish -- a tropical freshwater fish known for its regenerative abilities and optically clear embryos -- to gather new information on the signalling process responsible for HSC generation.

Using high-resolution microscopy researchers made a film of how these stem cells form inside the embryo, which captured the process of their formation in dramatic detail.

Professor Currie said when playing back these films they noticed that HSCs require a "buddy" cell type to help them form. These "buddies," known as endotome cells, have stem cell inducing properties,

"Endotome cells act like a comfy sofa for pre HSCs to snuggle into, helping them progress to become fully fledged stem cells. Not only did we identify some of the cells and signals required for HSC formation, we also pinpointed the genes required for endotome formation in the first place," Professor Currie said.

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Stem cell discovery: Australian scientists make significant find while studying zebrafish

August 14th, 2014 8:41 pm

Australian scientists studying zebrafish have stumbled upon what they say is one of the most significant discoveries in stem cell research.

In research published on Thursday in the journal Nature, the Monash University scientists revealed that they uncovered how one of the most important stem cells in blood and bone marrow, the haematopoietic stem cell (HSC), is formed.

Professor Peter Currie, from Monash University's Australian Regenerative Medicine Institute, said the discovery brought researchers closer to growing HSCs in a lab.

"HSCs are the basis of bone marrow transplantations as a therapy, so when a leukaemia patient receives bone marrow, it's really these HSCs that do the heavy lifting," Professor Currie said.

"So when clinicians do bone marrow transplants, they need to find a matching donor recipients and we know that's a hit-or-miss procedure.

"So for many years people have been trying to make HSCs in the dish, and they've had very little success in doing this."

Professor Currie, who led the study, said the discovery brought scientists much closer to achieving that aim.

"It's the discovery of a completely new cell type that basically is required to give instructions to the HSC to make it become what it needs to become," he said.

"It means we now understand how HSC form in the body better, we can use that information to try to grow these cells in the dish and we hope that will lead to better treatment for people with leukaemia and blood disorders."

Professor Currie said he specialises in muscle stem cell biology and accidentally came across the discovery while studying muscle stem cells in zebrafish.

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What Is Non-Embryonic Stem Cell Skin Care? – Video

August 14th, 2014 2:41 pm


What Is Non-Embryonic Stem Cell Skin Care?
We all know the buzz surrounding stem cells, but Lifeline Skin Care boasts the only line of non-embryonic stem cells. Combined with hyaluronic acid and vitamin C, Lifeline #39;s Eye Firming Complex...

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Stem cell therapy for central nerve system injuries: Glial cells hold the key

August 14th, 2014 12:40 am

PUBLIC RELEASE DATE:

12-Aug-2014

Contact: Meng Zhao eic@nrren.org 86-138-049-98773 Neural Regeneration Research

Mammalian adult central nerve system (CNS) injuries are devastating because of the intrinsic difficulties for effective neuronal regeneration. The greatest problem to be overcome for CNS recovery is the poor regeneration of neurons and myelin-forming cells, oligodendrocytes. Endogenous neural progenitors and transplanted exogenous neuronal stem cells can be the source for neuronal regeneration. However, because of the harsh local microenvironment, they usually have very low efficacy for functional neural regeneration which cannot compensate for the loss of neurons and oligodendrocytes. Glial cells (including astrocytes, microglia, oligodendrocytes and NG2 glia) are the majority of cells in CNS that provide support and protection for neurons. Inside the local microenvironment, glial cells largely influence local and transplanted neural stem cells survival and fates. This review critically analyzes current finding of the roles of glial cells in CNS regeneration, and highlights strategies for regulating glial cells' behavior to create a permissive microenvironment for neuronal stem cells. The Perspectives paper published in Neural Regeneration Research (Vol. 9, No. 13, 2014).

###

Article: "Stem cell therapy for central nerve system injuries: glial cells hold the key" by Li Xiao, Chikako Saiki, Ryoji Ide (1 Pharmacology Department, The Nippon Dental University, School of Life Dentistry at Tokyo, Tokyo, Japan; 2 Physiology Department, The Nippon Dental University, School of Life Dentistry at Tokyo, Tokyo, Japan).

Xiao L, Saiki C, Ide R. Stem cell therapy for central nerve system injuries: glial cells hold the key. Neural Regen Res. 2014;9(13):1253-1260.

Contact: Meng Zhao eic@nrren.org 86-138-049-98773 Neural Regeneration Research http://www.nrronline.org/

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

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Cedars-Sinai Heart Institute Opens First-of-its-Kind Research Stem Cell Clinic for Cardiac Patients

August 13th, 2014 2:45 am

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Newswise LOS ANGELES (Aug. 12, 2014) Regenerative medicine experts at the Cedars-Sinai Heart Institute have opened a new clinic to evaluate heart and vascular disease patients for participation in stem cell medical studies.

Led by Eduardo Marbn, MD, PhD, director of the Cedars-Sinai Heart Institute, and Timothy Henry, MD, director of the Heart Institutes Cardiology Division, the doctors and researchers at the Cedars-Sinai Heart Institute Regenerative Medicine Clinic use a scientific approach to assess the possible benefits of stem cells to repair damaged or diseased cardiovascular tissues. The clinic is believed to be the first at a major U.S. academic medical center dedicated to matching patients with appropriate stem cell clinical trials, whether those research interventions are available at the medical center or at other institutions.

The Heart Institute Regenerative Medicine Clinic offers consultative services for patients with heart and vascular disease who may qualify for investigative stem cell therapy. The goal is to provide research options to patients who remain symptomatic on their current management regimen, or for patients with stable heart disease who are concerned about disease progression.

Over the past decade, medical experts have predicted that in the future, stem cell therapies would transform heart disease treatment and save lives, said Shlomo Melmed, MD, dean of the Cedars-Sinai faculty and the Helene A. and Philip E. Hixon Distinguished Chair in Investigative Medicine. At Cedars-Sinai, we have a track record of successfully directing cardiac stem cell studies as well as transferring innovations from the laboratory to the patient bedside.

In 2009, Marbn and his team completed the worlds first procedure in which a patients own heart tissue was used to grow specialized heart stem cells. The specialized cells were then injected back into the patients heart in an effort to repair and re-grow healthy muscle in a heart that had been injured by a heart attack. Results, published in The Lancet in 2012, showed that one year after receiving the stem cell treatment, heart attack patients demonstrated a significant reduction in the size of the scar left on the heart muscle after a heart attack.

Henry has served as principal investigator of multiple large, multicenter trials in acute coronary syndromes, myocardial infarction and angiogenesis, including several ongoing cardiovascular stem cell trials. He also is principal investigator for one of seven NIH Clinical Cardiovascular Stem Cell Centers.

Our goal is to help make stem cells a regular treatment option for heart disease, Henry said. Right now, many patients with advanced heart disease have limited treatment options. Stem cells offer not only hope but a real chance of a game-changing treatment.

As part of each patients assessment in the Heart Regenerative Medicine Clinic, physicians will evaluate patients interested in participating in stem cell clinical trials at Cedars-Sinai and, for patients willing to travel at other medical institutions across the nation. For patients willing to travel to participate in research, Cedars-Sinai physicians will work closely with investigators at other centers to expedite referrals and seamlessly transfer all relevant medical records.

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Cedars-Sinai Heart Institute Opens First-of-its-Kind Research Stem Cell Clinic for Cardiac Patients

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ARTAS FUE Hair Transplant and Stem Cell Therapy – Video

August 13th, 2014 2:45 am


ARTAS FUE Hair Transplant and Stem Cell Therapy
Dr. William Yates speaks with another happy patient showing great results after a 2000 graft hair transplant utilizing the ARTAS FUE Robotic Hair Transplant ...

By: William Yates

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MDI Science Caf Regenerative Medicine and the End of Aging – Video

August 12th, 2014 2:41 pm


MDI Science Caf Regenerative Medicine and the End of Aging
What lies behind the remarkable potential of the human body to rebuild itself and why aren #39;t we better at it? Our imaginations have been captivated by the prospect of stem cells in our adult...

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Clinical Trial Evaluates Safety of Stem Cell Transplantation in Spine

August 12th, 2014 2:46 am

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Newswise Researchers at the University of California, San Diego School of Medicine have launched a clinical trial to investigate the safety of neural stem cell transplantation in patients with chronic spinal cord injuries. This Phase I clinical trial is recruiting eight patients for the 5-year study.

The goal of this study is to evaluate the safety of transplanting neural stem cells into the spine for what one day could be a treatment for spinal cord injuries, said Joseph Ciacci, MD, principal investigator and neurosurgeon at UC San Diego Health System. The studys immediate goal, however, is to determine whether injecting these neural stem cells into the spine of patients with spinal cord injury is safe.

Related goals of the clinical trial include evaluating the stem cell grafts survival and the effectiveness of immunosuppression drugs to prevent rejection. The researchers will also look for possible therapeutic benefits such as changes in motor and sensory function, bowel and bladder function, and pain levels.

Patients who are accepted for the study will have spinal cord injury to the T7-T12 level of the spines vertebrae and will have incurred their injury between one and two years ago.

All participants will receive the stem cell injection. The scientists will use a line of human stem cells approved by the U.S. FDA for human trials in patients with chronic traumatic spinal injuries. These cells were previously tested for safety in patients with amyotrophic lateral sclerosis (ALS).

Since stem cell transplantation for spinal cord injury is just beginning clinical tests, unforeseen risks, complications or unpredictable outcomes are possible. Careful clinical testing is essential to ensure that this type of therapy is developed responsibly with appropriate management of the risks that all medical therapies may present.

Pre-clinical studies of these cells by Ciacci and Martin Marsala, MD, at the UC San Diego School of Medicine, showed that these grafted neural stem cells improved motor function in spinal cord injured rats with minimal side effects indicating that human clinical trials are now warranted.

This clinical trial at UC San Diego Health System is funded by Neuralstem, Inc. and was launched and supported by the UC San Diego Sanford Stem Cell Clinical Center. The Center was recently created to advance leading-edge stem cell medicine and science, protect and counsel patients, and accelerate innovative stem cell research into patient diagnostics and therapy.

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Beyond DNA: Epigenetics Plays Large Role in Blood Formation

August 12th, 2014 2:46 am

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Newswise Blood stem cells have the potential to turn into any type of blood cell, whether it be the oxygen-carrying red blood cells, or the immune systems many types of white blood cells that help fight infection. How exactly is the fate of these stem cells regulated? Preliminary findings from research conducted by scientists from the Weizmann Institute of Science and the Hebrew University are starting to reshape the conventional understanding of the way blood stem cell fate decisions are controlled, thanks to a new technique for epigenetic analysis they have developed. Understanding epigenetic mechanisms (environmental influences other than genetics) of cell fate could lead to the deciphering of the molecular mechanisms of many diseases, including immunological disorders, anemia, leukemia, and many more. It also lends strong support to findings that environmental factors and lifestyle play a more prominent role in shaping our destiny than previously realized.

The process of differentiation in which a stem cell becomes a specialized mature cell is controlled by a cascade of events in which specific genes are turned on and off in a highly regulated and accurate order. The instructions for this process are contained within the DNA itself in short regulatory sequences. These regulatory regions are normally in a closed state, masked by special proteins called histones to ensure against unwarranted activation. Therefore, to access and activate the instructions, this DNA mask needs to be opened by epigenetic modifications of the histones so it can be read by the necessary machinery.

In a paper published in Science, Dr. Ido Amit and David Lara-Astiaso of the Weizmann Institutes Department of Immunology, along with Prof. Nir Friedman and Assaf Weiner of the Hebrew University of Jerusalem, charted for the first time histone dynamics during blood development. Thanks to the new technique for epigenetic profiling they developed, in which just a handful of cells as few as 500 can be sampled and analyzed accurately, they have identified the exact DNA sequences, as well as the various regulatory proteins, that are involved in regulating the process of blood stem cell fate.

Their research has also yielded unexpected results: As many as 50% of these regulatory sequences are established and opened during intermediate stages of cell development. This means that epigenetics is active at stages in which it had been thought that cell destiny was already set. This changes our whole understanding of the process of blood stem cell fate decisions, says Lara-Astiaso, suggesting that the process is more dynamic and flexible than previously thought.

Although this research was conducted on mouse blood stem cells, the scientists believe that the mechanism may hold true for other types of cells. This research creates a lot of excitement in the field, as it sets the groundwork to study these regulatory elements in humans, says Weiner.

Discovering the exact regulatory DNA sequence controlling stem cell fate, as well as understanding its mechanism, holds promise for the future development of diagnostic tools, personalized medicine, potential therapeutic and nutritional interventions, and perhaps even regenerative medicine, in which committed cells could be reprogrammed to their full stem cell potential.

Dr. Ido Amits research is supported by the M.D. Moross Institute for Cancer Research; the J&R Center for Scientific Research; the Jeanne and Joseph Nissim Foundation for Life Sciences Research; the Abramson Family Center for Young Scientists; the Wolfson Family Charitable Trust; the Abisch Frenkel Foundation for the Promotion of Life Sciences; the Leona M. and Harry B. Helmsley Charitable Trust; Sam Revusky, Canada; the Florence Blau, Morris Blau and Rose Peterson Fund; the estate of Ernst and Anni Deutsch; the estate of Irwin Mandel; and the estate of David Levinson. Dr. Amit is the incumbent of the Alan and Laraine Fischer Career Development Chair.

The Weizmann Institute of Science in Rehovot, Israel, is one of the world's top-ranking multidisciplinary research institutions. Noted for its wide-ranging exploration of the natural and exact sciences, the Institute is home to scientists, students, technicians, and supporting staff. Institute research efforts include the search for new ways of fighting disease and hunger, examining leading questions in mathematics and computer science, probing the physics of matter and the universe, creating novel materials, and developing new strategies for protecting the environment.

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Beyond DNA: Epigenetics Plays Large Role in Blood Formation

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Nationally Recognized Beverly Hills Orthopedic Surgeon, Dr. Raj, Now Offering Stem Cell Procedures to Help Patients …

August 12th, 2014 2:45 am

Beverly Hills, California (PRWEB) August 11, 2014

Nationally recognized Beverly Hills orthopedic surgeon, Dr. Raj, is now offering stem cell procedures to help patients avoid the need for surgery. This may include joint replacement along with tendon or ligament surgery. For more information on stem cell therapy and scheduling at the Beverly Hills Orthopedic Institute, call (310) 247-0466.

As the benefit of stem cells for repair and regeneration of human tissue has evolved, the opportunity to avoid surgery has too. This includes those with cartilage degeneration, tendonitis and ligament injury. Dr. Raj has been a pioneer in bringing stem cell therapies to the forefront, and is now offering the procedures to all patients.

According to Celebrity Fitness Expert Dr. Raj, a nationally recognized Double Board Certified Orthopedic Surgeon at the Beverly Hills Orthopedic Institute, stem cell injections are being used to heal conditions that used to require surgery. Dr. Raj has been featured on The Doctors, SPIKE TV, NBC, CBS, Martha Stewart Living Radio, Beverly Hills Times and has been named Best of LA by KCAL 9 as well we making Americas Top Orthopedics List in 2007, 2009, 2010, and 2011.

Dr. Raj explains that stem cells have started a medical revolution and have altered the way doctors approach treatment. Stem cells help to regenerate the damaged cartilage within a joint and allow patients to take a more conservative route, adds Dr. Raj. Surgery should be a last case scenario after all other options have been exhausted.

For those individuals suffering from joint arthritis of the hip, knee, shoulder or ankle, surgery is an elective decision with nonsurgical options that traditionally did not alter the course of arthritis. They have merely acted as a "band aid" for pain relief, but not effective at long term relief due to healing arthritis.

Stem cell therapy offers the opportunity for relief and increased activity, while staying out of the operating room. The procedures are outpatient and safe, with minimal risks involved.

For more information on the stem cell procedures provided with the top orthopedic doctor in Los Angeles and Beverly Hills, call (310) 247-0466.

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BioEden calls for transparancy and education on stem cell availability

August 12th, 2014 2:45 am

(PRWEB UK) 11 August 2014

BioEden the specialist tooth stem cell bank calls for a more intelligent approach, transparency and public education regarding stem cell banking.

"The public needs to be made aware that the success of stem cell medicine is largely dependant on the right material being available at the right time," says Tony Veverka Group CEO of the rapidly expanding specialist bank.

"With 1 in 3 people predicted to use stem cell therapy within their lifetime people need to know what their choices are at a time when they are able to do something about it, for example obtaining stem cells from their childrens naturally shed baby teeth."

BioEden pioneered the banking of stem cells from childrens baby teeth in 2006 in Austin Texas, and now operates in 21 countries.

BioEden says its unique process has many advantages over other forms and sources of stem cells, and eliminates the costly and painful process of getting stem cells from bone marrow for example.

The BioEden process is patent protected and offers the most natural form of stem cell banking that exists today.

"It is nonsense to say that a dental surgeon needs to extract a childs baby tooth in order to get the best result. The tooth falls out naturally and providing the stem cell bank offers quality transportation and processing, not even dental intervention is required," says Mr Veverka.

There are significant advantages in banking stem cells from teeth over cord blood for example, including the potential for a much wider therapeutic application, its non-invasive, not limited to the number of cells such as with cord blood during the birthing process, and is the least expensive form of private banking there is.

Banking your child's cells is the only way of ensuring a perfect stem cell match, eliminating the emotional distress caused when no match can be found.

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BioEden calls for transparancy and education on stem cell availability

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Plant Stem Cells Reverse Aging Demo – Video

August 11th, 2014 2:54 am


Plant Stem Cells Reverse Aging Demo
Our special formulated stem cell oral beauty supplement can reverse aging! We provide OEM/private label/ contract manufacturing services.

By: QD Herbs

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Due to a radical new approach by stem cell bank BioEden future generations could be guaranteed a stem cell match

August 10th, 2014 8:46 pm

(PRWEB UK) 9 August 2014

Stem cell therapy and treatments continue to move on in finding cures for diseases that in the past were thought to be incurable. The success of stem cell treatment and therapy relies to a great extent on the ability for the patient to have a stem cell match. Although stem cell banking has been available for a number of years, the cost for many has been a barrier.

Specialist stem cell bank BioEden who operate in 21 countries have come up with a solution that brings this potentially life saving opportunity within an affordable range for the majority.

Their aim is to make stem cell therapy an affordable reality and hope that their new approach which includes a low monthly membership option will do just that.

As more and more people bank their children's stem cells for their future use, the problem of finding a stem cell match could become a thing of the past.

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Due to a radical new approach by stem cell bank BioEden future generations could be guaranteed a stem cell match

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Global Stem Cells Group and Regenestem Announce Launch of Stem Cell Treatment Center in Cozumel, Mexico

August 10th, 2014 4:47 am

Miami (PRWEB) August 10, 2014

Regenestem, a division of the Global Stem Cells Group, Inc., has announced the launch of a new stem cell treatment center in Cozumel, Mexico, offering the most advanced protocols and techniques in cellular medicine to patients from around the world.

A team of stem cell medical professionals led by Rafael Moguel, M.D., an advocate and pioneer in the use of stem cell therapies to treat a range of medical conditions, will provide cutting edge therapies and follow-up treatment under the Regenestem brand.

In June, Global Stem Cells Group opened the Regenestem Asia Clinic in Manila, Philippines, adding a new state-of-the-art regenerative medicine facility to the company's growing global presence that includes clinics in Miami, New York, Los Angeles, and Dubai. Regenestem Asia facility marks the first Regenestem brand clinic in the Philippines.

Regenestem provides stem cell treatments for a variety of diseases and conditions, including arthritis, autism, chronic obstructive pulmonary disease (COPD), diabetes, and multiple sclerosis at various facilities worldwide. Regenestem Mexico will have an international staff experienced in administering the leading cellular therapies available.

Regenestem Mexico is certified for the medical tourism market, and staff physicians are board-certified or board-eligible. Regenestem clinics provide services in more than 10 specialties, attracting patients from the United States and around the world.

The Global Stem Cells Group and Regenestem are committed to the highest of standards in service and technology, expert and compassionate care, and a philosophy of exceeding the expectations of their international patients.

For more information, visit the Regenestem website, email info(at)regenstem(dot)com, or call 305-224-1858.

About Regenestem:

Regenestem, a division of the Global Stem Cells Group, Inc., is an international medical practice association committed to researching and producing comprehensive stem cell treatments for patients worldwide. Having assembled a highly qualified staff of medical specialistsprofessionals trained in the latest cutting-edge techniques in cellular medicineRegenestem continues to be a leader in delivering the latest protocols in the adult stem cell arena.

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Stem cell treatment holds hope for better stroke recovery

August 10th, 2014 4:47 am

A new first-of-its kind pilot study has revealed that stem cell treatment can significantly improve recovery from stroke in humans.

The therapy uses a type of cell called CD34+ cells, a set of stem cells in the bone marrow that give rise to blood cells and blood vessel lining cells. Rather than developing into brain cells themselves, the cells are thought to release chemicals that trigger the growth of new brain tissue and new blood vessels in the area damaged by stroke.

The patients were treated within seven days of a severe stroke, in contrast to several other stem cell trials, most of which have treated patients after six months or later. The Imperial researchers believe early treatment might improve the chances of a better recovery.

Dr Soma Banerjee, Consultant in Stroke Medicine at Imperial College Healthcare NHS Trust, said that the treatment appeared to be safe and that it's feasible to treat patients early when they might be more likely to benefit.

However, it's too early to draw definitive conclusions about the effectiveness of the therapy and more tests to work out the best dose and timescale for treatment before starting larger trials, she further added.

The study is published in the journal Stem Cells Translational Medicine.

(Posted on 09-08-2014)

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Stem Cell Therapy – Am I A Candidate – Video

August 10th, 2014 4:46 am


Stem Cell Therapy - Am I A Candidate
Farhan Saddiqi, MD discusses the process of determining whether you are a candidate for Stem Cell Therapy at the Trinity Stem Cell Institute.

By: SMU Productions - Tampa Video Production

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Stem Cell Therapy - Am I A Candidate - Video

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Lorna Tolentino reveals the secret to her youthful looks

August 10th, 2014 4:46 am

Kasi kaka-quit ko lang ng smoking, Lorna Tolentino proudly announces.

The 52-year-old actress also adds, Mag-wa-one month na sa August 14.

Asked whether shes having a hard time adjusting her lifestyle, she says, Ay no, hindi naman talaga ako ganun Im not really talaga sobrang sobrang smoker.

Right now, Lorna is taking supplements such as vitamin B1, B complex, glutathione, and mangosteen and malunggay capsules.

Siyempre nung nag-50 ako, mas iniisip ko na mas tumagal pa.

Kasi siyempre, 'di ba, gone too soon si Rudy [Fernandez], kaya siyempre kailangan mas mahaba pa, lalo na because of my apo, yun ang nag-i-inspire sa akin, she confesses.

When asked whether shes ok with Lyla Victoria, Raphael's (Lorna's eldest son) daughter, entering showbiz, Lorna answers, Commercial kung meron, oo tatangapin ko.

Lorna enthusiastically talks about her two-year-old apo, whom she refers to as still being in her makulit stage, Shes ok, actually yung kanya intellectual [maturity] ano, something na pinapaano sa mga doctor, for four years old na.

She also complements Leana, Lylas mother, for teaching her grandchild, Talagang kinu-congratulate ko si Leana, because shes a teacher, talagang mas kaya niya i-guide.

STEM CELL THERAPY.Lorna Tolentino, who has undergone stem cell therapy, narrates how the procedure helped her health concerns.

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Stem cells show promise for stroke in pilot study

August 10th, 2014 4:46 am

A stroke therapy using stem cells extracted from patients' bone marrow has shown promising results in the first trial of its kind in humans.

Five patients received the treatment in a pilot study conducted by doctors at Imperial College Healthcare NHS Trust and scientists at Imperial College London.

The therapy was found to be safe, and all the patients showed improvements in clinical measures of disability.

The findings are published in the journal Stem Cells Translational Medicine. It is the first UK human trial of a stem cell treatment for acute stroke to be published.

The therapy uses a type of cell called CD34+ cells, a set of stem cells in the bone marrow that give rise to blood cells and blood vessel lining cells. Previous research has shown that treatment using these cells can significantly improve recovery from stroke in animals. Rather than developing into brain cells themselves, the cells are thought to release chemicals that trigger the growth of new brain tissue and new blood vessels in the area damaged by stroke.

The patients were treated within seven days of a severe stroke, in contrast to several other stem cell trials, most of which have treated patients after six months or later. The Imperial researchers believe early treatment may improve the chances of a better recovery.

A bone marrow sample was taken from each patient. The CD34+ cells were isolated from the sample and then infused into an artery that supplies the brain. No previous trial has selectively used CD34+ cells, so early after the stroke, until now.

Although the trial was mainly designed to assess the safety and tolerability of the treatment, the patients all showed improvements in their condition in clinical tests over a six-month follow-up period.

Four out of five patients had the most severe type of stroke: only four per cent of people who experience this kind of stroke are expected to be alive and independent six months later. In the trial, all four of these patients were alive and three were independent after six months.

Dr Soma Banerjee, a lead author and Consultant in Stroke Medicine at Imperial College Healthcare NHS Trust, said: "This study showed that the treatment appears to be safe and that it's feasible to treat patients early when they might be more likely to benefit. The improvements we saw in these patients are very encouraging, but it's too early to draw definitive conclusions about the effectiveness of the therapy. We need to do more tests to work out the best dose and timescale for treatment before starting larger trials."

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Regenerated stem cells could well prove a cure for HIV/AIDS – Video

August 9th, 2014 6:47 pm


Regenerated stem cells could well prove a cure for HIV/AIDS
Regenerated stem cells could well prove a cure for HIV/AIDS. A Berlin Patient is living proof of this. He underwent a stem cell transplant in 2007.

By: SABC Digital News

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3 methods for passaging of pluripotent stem cells – Video

August 9th, 2014 6:47 pm


3 methods for passaging of pluripotent stem cells
Here are 3 methods for passaging of pluripotent stem cells, or PSCs, including our recommended method using StemMACS iPS-Brew XF, for minimal stress to cells and less hands-on time. Learn more...

By: Miltenyi Biotec

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