Aarkstore -Stem Cell Research in Cardiology
This market insight report on Stem Cell Research in Cardiology emphasizes on the market for stem cells in Cardiology. The study is segmented by Source (Allogenic and Autogenic) and by Type...
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Aarkstore -Stem Cell Research in Cardiology - Video
The Stem Cell #39;s Journey
DescriptionStem cells have the ability to transform into many different cell types, but Stemmy the stem cell possesses a unique gift: he can transform cells around him into duplicates of himself....
By: Jeff Alu
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The Stem Cell's Journey - Video
Understanding Niche Cells | Science: Out of the Box
Johns Hopkins cell biologist Erika Matunis explains how understanding the cells that take care of stem cells may shed light on cancer. To see more Science: Out of the Box videos, visit http://www...
By: Johns Hopkins Medicine
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Understanding Niche Cells | Science: Out of the Box - Video
TWIS Minion / Science Island Hangout October 16, 2014
Amy Lynn Thompson, Ed Dyer, AJ Smith and Dale Liebrecht talking about Mars missions, the Milky Way being a bully, Black Holes, the mighty stem cells healing hearts and eyes and more. Show...
By: Edward Dyer
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TWIS Minion / Science Island Hangout October 16, 2014 - Video
Dr Nathan Newman explains Stem Cells
Dr. Nathan Newman explains how adult stem cells are revolutionizing medicine and how they #39;re already being used in treatment of cosmetic and reconstructive to rejuvenate damaged tissues and...
By: Yingyao
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Dr Nathan Newman explains Stem Cells - Video
Can Stem Cell Injections Cure Blindness?
Stem cells may be able to cure blindness through injecting them into the eyes of people who are blind. The procedure worked over a three year period in restoring the vision of eighteen patients...
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Can Stem Cell Injections Cure Blindness? - Video
FranchiseStemcell Fat Stem Cell Therapy Anti Aging
Fat Stem Cell Therapy Anti Aging .
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FranchiseStemcell Fat Stem Cell Therapy Anti Aging - Video
MEDS-380
Stem cells have captured the imaginations of scientists, physicians, and the general public for their ability to revolutionize not only how we treat diseases but the foundations of life itself....
By: Erin Yamauchi
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MEDS-380 - Video
Dr Charles Krome Stem Cell Therapy
This video is about Dr Charles Krome Stem Cell Therapy.
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Dr Charles Krome Stem Cell Therapy - Video
Shassers Trials
Shassers Trials ...Outside Wormwood Scrubs Queen Charlottes Hospital ..after an unsuccessful appointment to discuss the stem cells that were implanted in me 30 years ago...letting off some...
By: Sharon Cooke
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Shassers Trials - Video
Overview of Regenerative Medicine Partnering Merger Acquisition Market
The report provides a detailed understanding and analysis of how and why companies enter regenerative medicine and stem cells partnering deals. The majority ...
By: John Brown
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Overview of Regenerative Medicine Partnering Merger & Acquisition Market - Video
Whats the kindest thing a stranger #39;s done for you?
Every day at Anthony Nolan incredible people save the life of a stranger by donating their stem cells. That got us thinking, what #39;s the most amazing thing a stranger has done for you? ...
By: Anthony Nolan
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Whats the kindest thing a stranger's done for you? - Video
Stem Cells, Blindness And Why The Media Loves Miracle Cures
Scientists researching the safety of stem cells have found the cells can help improve sight in patients with vision impairments. Follow Sebastian Martinez: http://www.twitter.com/sebastiansings...
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Stem Cells, Blindness And Why The Media Loves Miracle Cures - Video
Dr. Deepak Srivastava, a leading biomedical research policy expert, will discuss "Stem Cells, Regenerative Medicine and Policy Impediments to the New Future" at Rice University's Baker Institute for Public Policy Oct. 21. The event is free and open to the public, but registration is required.
Who: Dr. Deepak Srivastava, the Baker Institute's nonresident scholar for biomedical research policy and the Younger Family Director and senior investigator at the Gladstone Institute of Cardiovascular Disease.
Neal Lane, the Malcolm Gillis University Professor, senior fellow in science and technology policy at Rice's Baker Institute for Public Policy and a professor of physics and astronomy, will give introductory remarks.
Stem cells and regenerative medicine are exciting and emerging fields of biomedical research, according to event organizers. Proposed applications include treating conditions such as blindness, diabetes and heart disease. Regenerative medicine could also help heal failing organ systems and replace damaged tissue. While these fields hold great promise for medicine, external factors limit and, in some cases, stall research, organizers said. Ethical controversies surrounding human embryonic stem cells, policy issues affecting federal and state funding and regulation, and economic pressures all play a role in determining the future of research.
In his presentation, Srivastava will explore the current and future potential of stem cells and regenerative medicine. Following the presentation, he will discuss policy challenges and opportunities with Lane.
The event is sponsored by the Baker Institute's Science and Technology Policy Program and the Health Policy Forum.
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Stem cell, regenerative medicine policies to be discussed at Rice's Baker Institute
Dunmore, Pennsylvania (PRWEB) October 17, 2014
VCA Dunmore Animal Hospital is proud to announce the addition of Shannon Layne, DVM and her interest in stem cell therapy to their team. Credentialed in Regenerative Cell Therapy with Vet-Stem since January of 2011, Dr. Layne has proudly been treating pets with osteoarthritis and ligament injuries in north-east Pennsylvania with stem cell therapy for the last four years.
Dr. Layne graduated from North Carolina State University, College of Veterinary Medicine in 2010 and has taken a special interest in Regenerative Veterinary Medicine and stem cell therapy since. In contrast to widely used drug therapies for pain management, cell-based therapies (like stem cell therapy) can promote healing, reduce inflammation, and decrease pain. Dr Layne also offers traditional Chinese veterinary medicine including acupuncture and Chinese herbs if clients are interested in a more holistic approach.
Stem cells are regenerative cells that can differentiate into many tissue types (reducing pain and inflammation) thus helping to restore range of motion and regenerate tendon, ligament and joint tissues (Vet-Stem.com/science). In a study using Vet-Stem Regenerative Cell Therapy on dogs with osteoarthritis of the hip joint it was found that regenerative cell therapy (adipose-derived stem cells) decreases patient discomfort and increases patient functional ability.
Once Dr. Layne has identified a patient as a good candidate for stem cell therapy the procedure begins with a fatty tissue collection from the patient. The tissue sample is sent overnight to Vet-Stems lab in California for processing. Once processed the stem cells are extracted and fresh, injectable doses of the patients stem cells are sent overnight, back to Dr. Layne at VCA Dunmore Animal Hospital. Within 48hrs of collecting a fat sample from a patient Dr. Layne is able to inject stem cells into (arthritic or injured) affected areas and regeneration and healing can begin.
At VCA Dunmore Animal Hospital Dr. Layne will be practicing in an 8,800 square foot, state of the art facility that includes two extensive surgery suites. For more information on VCA Dunmore Animal Hospital please visit their website at http://www.vcahospitals.com/dunmore.
About Vet-Stem, Inc.
Since its formation in 2002, Vet-Stem, Inc. has endeavored to improve the lives of animals through regenerative medicine. As the first company in the United States to provide an adipose-derived stem cell service to veterinarians for their patients, Vet-Stem pioneered the use of regenerative stem cells for horses, dogs, cats, and some exotics. In 2004 the first horse was treated with Vet-Stem Regenerative Cell Therapy for a tendon injury that would normally have been career ending. Ten years later Vet-Stem celebrated its 10,000th animal treated, and the success of establishing stem cell therapy as a regenerative medicine for certain inflammatory, degenerative, and arthritic diseases. As animal advocates, veterinarians, veterinary technicians, and cell biologists, the team at Vet-Stem tasks themselves with the responsibility of discovering, refining, and bringing to market innovative medical therapies that utilize the bodys own healing and regenerative cells.
For more information about Vet-Stem and Regenerative Veterinary Medicine visit http://www.vet-stem.com or call 858-748-2004.
Embryonic Stem Cell research has been an area of immense promise, but there have been few studies which have shown how these cells can benefit patients in real world applications. Embryonic Stem Cells have the ability to turn into any form of adult cell, which opens up the opportunity for incredible medical advances. On the other hand, the field of medical study is still quite new, and the fruits of that research are still largely in the future.
In just the past few days, however, new research was published that is the first of its kind to present the applied use of Embryonic Stem Cells as a medical treatment, with clear and profound results. Embryonic Stem Cells were successfully used to restore some vision in patients that suffer from chronic, degenerative eye conditions.
Eighteen patients were treated with Embryonic Stem Cells, and the treatment effectively enhanced vision in the majority of these patients. These findings are quite miraculous, but a larger scale study needs to be performed to discover the full applications of this treatment, because the original group of participants was so small. Furthermore, the participants need to be followed for a longer period of time to assess the full benefits of the treatment, as they have only been monitored for under two years.
The benefits of Embryonic Stem Cells surprised even the researchers that conducted the study. They provided the Stem Cell Treatments experimentally, but did not have any strong inclination that the treatment would benefit the patients, because their vision loss was so significant and severe.
The lead researcher of the study, Dr. Steven Schwartz, explains that he was simply amazed by the results, and is hopeful that the treatment will continue to benefit the patients, and eventually become a viable treatment for men and women across the country. Dr. Schwartz is a vision specialist from the University of California-Los Angeles. This study was released by The Lancet, one of the preeminent academic journals in Great Britain.
How Did Researchers Treat the Patients for Vision Loss with Embryonic Stem Cells?
Embryonic Stem Cells are hypothesized to work, because they emulate the structure and function of nearby cells when they are implanted into the patient. Embryonic Stem Cells develop in a particular way based upon the signals they receive from the human body. In the case of this particular study, Embryonic Stem Cells were implanted into the retina of patients that had degenerating optical neurons. In doing so, the Embryonic Stem Cells mimicked the normal function of the dying Retina, improving the vision of the patient.
Most researchers that work in vision care and have examined the details of the study find the results exciting, but they also feel that it was important to withhold full judgment until further clinical trials had been conducted.
Dr. Anthony Atala of Wake Forest reiterates that this Stem Cell Vision Study is the first of its kind that explicitly shows how Embryonic Stem Cells can directly benefit the patient.
This study, at its core, is a proof of concept for the potential of Embryonic Stem Cell Therapy. All of the hypotheses in the world don't mean a thing if they aren't able to be converted into actionable medical science. If further studies go on to prove the effectiveness of Embryonic Stem Cells for this purpose, in the future, the range of options will likely expand into other forms of treatment intended to improve outcomes in patients with chronic, degenerative conditions, such as lung disease and heart disease. In addition, there are a variety of other ways in which Embryonic Stem Cells could be effective, including physical rehabilitation.
Why Are Embryonic Stem Cells Such an Important Area of Research?
Embryonic Stem Cell Research is an exciting area of study because of the potentially universal uses that these Stem Cells may offer patients of all kinds. Embryonic Stem Cells contain all of the DNA and information that can be used to make a living, breathing human being, but entirely undifferentiated. As the body of research continues to grow, it becomes more and more clear that these stem cells can be controlled in a way that allows them to develop into any other kind of tissue.
Of course, we are potentially decades away from unlocking the full potential of this treatment, and, until now, Embryonic Stem Cells have never been used to clearly and effectively treat a medical condition. There is hope that these stem cells will one day be able to mitigate the effects of a variety of conditions, such as paralysis, diabetes, and dementia.
This Embryonic Stem Cell Vision Study is the first FDA Study using Embryonic Stem Cells which has yielded unequivocally positive results. The study is truly significant, and even groundbreaking.
What Kind of Vision Impairment did This Study Treat?
The patients that were treated in this study were all afflicted with one of two forms of central vision impairment: Stargardt's Macular Dystrophy and Macular Degeneration, a condition in which the retina starts to degrade, making it harder for the patient to engage their full visual field. These two forms of visual impairment are the most common forms of blindness in the United States, in both children and adults.
These conditions directly impact the ability to focus on objects in one's visual field. Everything simply fades into a blur. The periphery is generally intact, but without central vision, it is impossible to focus or differentiate between objects in any meaningful fashion.
The researchers in this study combined their efforts with Advanced Cell Technology, Incorporated, a Stem Cell Research facility in Marlborough, Massachusetts. In this study, the researchers used undifferentiated Embryonic Stem Cells and converted them into Retinal Pigment Epithelial Cells, which are vital for central vision, and are the cells which deteriorate as a result of the two most common visual impairments in the United States. Using Embryonic Stem Cells, they created over 50,000 of these cells, and implanted them directly into the retina of the participants.
The hypothesis was that the patient's body would use these fresh and healthy epithelial cells to repair the damage which was caused by the body's own cells that had fallen into disrepair. The researchers were not confident that this treatment would work, but considering that the patients had no other recourse to potentially restore their vision, this research did offer them the unique opportunity to potentially experience benefits that no human being had experienced before, with few to no potential drawbacks, even if the procedure was unsuccessful.
None of the researchers believed that these Stem Cells would improve the vision of their patients. The goal of the study was simply to test the safety of the procedure and treatment before moving on to more directed studies. The scientists that conducted this research worried that this treatment could lead to unwanted side-effects. For example, they could not rule out the possibility that the treatment would promote the development of tumors in the patients eyes, or that it could hasten the visual degradation rather than relieve it.
In order to test their theories without putting the vision of the patient at risk, the researchers selected only subjects that had severe vision issues which left them all but blind. This mitigated the potential risks of the treatment to the patient, but it also meant that it significantly reduced the odds, in theory, that the treatment could provide any tangible benefit to the patient. Dr. Schwartz explains that, because of the issues in selecting patients, he and his fellow researchers had little confidence that the treatment could actually lead to real and significant vision improvement.
It's important to look at this study realistically. Although this trial has been incredibly promising, it's still a long way from reaching the market, and there could always be snags along the way. It's important to recognize that Stem Cell Treatments, although they will all but certainly be available for a wide variety of conditions, are still years off from widespread use. It's important that patients understand that this Stem Cell Therapy is not something that's really available to patients at this time, though it will be in the future.
Side Effects of Stem Cell Vision Therapy
Some of the participants did experience issues resulting from the Stem Cell Therapy, mostly because of medications that they had to take to prevent the Immune System from responding negatively to the treatment. Luckily, none of these side-effects were overly problematic, and none of the patients had to suspend treatment. They found that, although the procedure did lead to some side-effects, the patients experienced no issues resulting directly from the Stem Cells.
Effectiveness of Stem Cell Therapy for Vision Loss
The authors of the study reported that, in the end, ten patients experienced a great improvement in their eyesight. Out of eighteen total patients, only one experienced a decline in vision quality, while the final seven patients either experienced no changes in eyesight or slight improvement.
Dr. Schwartz was amazed by the findings. He explains that, some of the patients that experienced these vision conditions had been suffering from deterioration for thirty years or more, without any real improvement, and that the Stem Cell Therapy directly led to improvements that they had never experienced before.
For example, one patient was a rancher that enjoyed riding horses, but, because of his vision problems, could no longer safely do so. After treatment, he could see well enough to go horseback riding safely. Before treatment, riding was far too dangerous, because he was visually unable to see things like fences or differentiate between objects at a distance in any meaningful way. Now, he can go back to his ranch and effectively corral his cattle, while also recognizing nearby dangers and being able to differentiate among objects in the distance with relative accuracy.
A second patient was a business-person that frequently traveled internationally to perform consultations. Vision problems prevented the patient from being able to travel unaccompanied through airports, but the treatment restored the patient's ability to travel without aid. A third patient was a graphic artist that had lost the ability to practice her craft. After treatment, she was able to see details in her furniture that were invisible to her before treatment.
A fourth patient from Santa Rosa, Isabella Beukes, had been unable to see clearly for longer than forty years. After only a few weeks of Stem Cell Treatment, her vision started to improve. In just that short period of time, she was able to see objects on her computer monitor, as well as recognize her clothes by color in the closet. After two years, she is able to go hiking alone in the forest close by her house. She explains that the Stem Cell Treatment impacted her life in a genuinely profound way. It changed her life and afforded her a level of independence that she hadn't felt in decades. She was honored and amazed that she had had the opportunity to participate in such a life-altering study.
Embryonic Stem Cell Research is Still Considered Ethically Questionable by Some
Embryonic Stem Cell Research is not without its detractors. The only way to get these cells is by taking apart an embryo, which, of course, has the potential to develop into a full-fledged human being. Those that feel that life begins at conception are opposed to such research, and feel that destroying embryos is the literal equivalent of ending a child's life. Although an embryo is just a clump of identical cells, many still afford them with this description.
Of course, even if ethical quandaries in the United States slow down research, Stem Cell Research in other countries will continue to grow and expand at a rapid rate, because the United States is unique in the first world with regard to these ethical issues.
When asked about these ethical issues, Dr. Schwartz points out that his goal as a vision specialist is to help people improve their eyesight, and to restore vision to the blind.
Induced Pluripotent Stem Cells Could One Day Replace Embryonic Stem Cells
There is also a push to unlock the secrets of creating new stem cells from the cells of existing patients. Researchers are in the process of learning how to literally, “turn back the clock,” reverting cells to their embryonic state, or a similar state. As of today, researchers have effectively been able to revert cells to a point of early development, but have issues restoring cells to a state identical to that of Embryonic Stem Cells. These cells may one day replace stem cells, allowing patients to use their own cells for regenerative treatment.
Continuing Research
As his prior research has proven that Stem Cells can be effective at restoring for vision in patients with Macular Degeneration and other visual disorders, Dr. Schwartz has expanded the pool of patients which are eligible for treatment, now including patients that still retain some vision, that are suffering from the same degenerative conditions. He has also begun to implant a larger volume of Stem Cells to find out whether more Stem Cells improve the rate of recovery. The success of his UCLA study has prompted expanded Clinical Trials in London, Philadelphia, Miami, and Boston.
3 hours ago by Vicky Just Naive-like stem cells could potentially be used to treat dementia or reduce organ transplants
Scientists from our university and Berlin have identified a type of human stem cell that appears to be "nave-like" able to develop into any type of cell. The discovery of this cell type could potentially have a large impact on our understanding of how humans develop and on the field of regenerative medicine.
The human embryonic stem cells (ESCs) that scientists currently study in the lab are able to develop into several different types of cell but are already pre-determined to some extent.
Published in the top scientific journal Nature, researchers from the Max Delbrck Centre for Molecular Medicine (MDC), Berlin, Germany and our university have for the first time discovered human ESCs that appear to behave like "nave" cells able to develop into any type of cell.
These nave-like cells, only previously found in mice, are easy to grow in the lab and could have huge potential for regenerating damaged tissues in the body, potentially leading to treatments for diseases such as dementia or reducing the need for organ transplantation.
Professor Laurence Hurst from our Department of Biology & Biochemistry and a co-author of the study explained: "Most stem cells are primed to some extent to become a certain type of cell. If you use the analogy of a train network, these cells are like one of the main London stations. Trains from Paddington can go to Cardiff or Exeter, but not to Norwich. In the same way, these cells can develop into a fixed number of different cell types.
"However the nave-like cells we've identified are like a central terminus; they are present earlier in the embryo's development and so we think their fates can go in any direction and become any type of cell."
Co-investigator Dr Zsuzsanna Izsvk, (MDC, corresponding author) said: "We were very excited by this discovery it was one of those Eureka moments that rarely happens in science."
The Bath and Berlin team found the nave-like cells by looking at which genes were expressed in very early human embryos. They pinpointed a virus called human endogenous retrovirus H (HERVH) that has become integrated into human DNA and was very highly expressed at just the right time and place in human embryos, where they would expect to see nave-like cells if they existed.
They identified a protein called LBP9, which is essential for the activity of HERVH in early embryos. Using a reporter system that made cells expressing HERVH via LBP9 glow green, the Berlin and our team found that they had purified cells that showed all of the hallmarks of a mouse nave cell.
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Scientists identify "nave-like" human stem cell
PUBLIC RELEASE DATE:
16-Oct-2014
Contact: Anita Srikameswaran SrikamAV@upmc.edu 412-578-9193 University of Pittsburgh Schools of the Health Sciences @UPMCnews
PITTSBURGH, Oct. 16, 2014 Despite previous indications to the contrary, the esophagus does have its own pool of stem cells, said researchers from the University of Pittsburgh School of Medicine in an animal study published online today in Cell Reports. The findings could lead to new insights into the development and treatment of esophageal cancer and the precancerous condition known as Barrett's esophagus.
According to the American Cancer Society, more than 18,000 people will be diagnosed with esophageal cancer in the U.S. in 2014 and almost 15,500 people will die from it. In Barrett's esophagus, the lining of the esophagus changes for unknown reasons to resemble that of the intestine, though gastro-esophageal reflux disease or GERD is a risk factor for its development.
"The esophageal lining must renew regularly as cells slough off into the gastrointestinal tract," said senior investigator Eric Lagasse, Pharm.D., Ph.D., associate professor of pathology, Pitt School of Medicine, and director of the Cancer Stem Cell Center at the McGowan Institute for Regenerative Medicine. "To do that, cells in the deeper layers of the esophagus divide about twice a week to produce daughter cells that become the specialized cells of the lining. Until now, we haven't been able to determine whether all the cells in the deeper layers are the same or if there is a subpopulation of stem cells there."
The research team grew pieces or "organoids" of esophageal tissue from mouse samples, and then conducted experiments to identify and track the different cells in the basal layer of the tissue. They found a small population of cells that divide more slowly, are more primitive, can generate specialized or differentiated cells, and have the ability to self-renew, which is a defining trait of stem cells.
"It was thought that there were no stem cells in the esophagus because all the cells were dividing rather than resting or quiescent, which is more typical of stem cells," Dr. Lagasse noted. "Our findings reveal that there indeed are esophageal stem cells, and rather than being quiescent, they divide slowly compared to the rest of the deeper layer cells."
In future work, the researchers will examine human esophageal tissues for evidence of stem cell dysfunction in Barrett's esophagus disease.
"Some scientists have speculated that abnormalities of esophageal stem cells could be the origin of the tissue changes that occur in Barrett's disease," Dr. Lagasse said. "Our current and future studies could make it possible to test this long-standing hypothesis."
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Pitt/McGowan Institute team discovers stem cells in the esophagus
TUESDAY, Oct. 14, 2014 (HealthDay News) -- A new study is the first to show the long-term safety of embryonic stem cell transplants to treat human disease.
The research involved 18 people who received the transplants to treat forms of macular degeneration, a leading cause of vision loss.
The transplants, which restored some sight in more than half of the patients, appeared safe up to three years after the procedure.
The study, funded by a U.S.-based company called Advanced Cell Technology, was published Oct. 14 in The Lancet.
"Embryonic stem cells have the potential to become any cell type in the body, but transplantation has been complicated by problems," lead author Dr. Robert Lanza, chief scientific officer at Advanced Cell Technology, said in a journal news release. Those problems include the rejection of the transplanted cells by the patient's immune system, as well as the danger that the cells might spur certain types of cancers called teratomas.
A teratoma is a type of cancer that occurs when stem cells develop into multiple types of cells and form incompatible tissues that can include teeth and hair.
As Lanza explained, because of these issues, scientists interested in embryonic stem cell therapy have tended to focused on sites in the body that typically do not produce a strong immune response. The eye is one such spot.
In the new study, human embryonic stem cells were first prompted to develop into eye cells called retinal pigment epithelial cells. They were then transplanted into nine people with Stargardt's macular dystrophy, and another nine with dry atrophic age-related macular degeneration.
Patient outcomes were tracked for up to three years after transplant. No signs of either cancer-like cell growth (hyperproliferation) or immune system rejection were found in any of the treated eyes after a median follow-up of 22 months, and the only adverse events were linked not to the transplanted cells, but to the eye surgery or immune system suppression needed for the transplant.
Overall, 10 of the 18 patients said they had significant improvements in their vision, and this improvement was only seen in the eyes that had received the stem cell treatment.
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Embryonic Stem Cell Therapy Shows Long-Term Effectiveness, Safety
Sniffing out new roles for stem cells in the brain
Scientists discovered an unexpected role for newborn cells by studying the wiring diagram of the mouse olfactory bulb, the part of the brain that turns smell...
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Sniffing out new roles for stem cells in the brain - Video